Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| intradermal vaccination using the novel microneedle device micronjet600: past, present, and future. | intradermal immunization has become a forefront of vaccine improvement, both scientifically and commercially. newer technologies are being developed to address the need to reduce the dose required for vaccination and to improve the reliability and ease of injection, which have been major hurdles in expanding the number of approved vaccines using this route of administration. in this review, 7 y of clinical experience with a novel intradermal delivery device, the micronjet600, which is a register ... | 0 | 25745830 |
| vaccines and recommendations for their use in inflammatory bowel disease. | the patient with inflammatory bowel disease will be predisposed to numerous infections due their immune status. it is therefore important to understand the immune and serologic status at diagnosis and to put the patient into an adapted vaccination program. this program would be applied differently according to two patient groups: the immunocompromised and the non-immunocompromised. in general, the first group would avoid the use of live-virus vaccines, and in all cases, inflammatory bowel diseas ... | 0 | 23538680 |
| vaccinating patients with inflammatory bowel disease. | patients with inflammatory bowel disease (ibd) are not vaccinated at the same rate as general medical patients. ibd places patients at increased risk for developing vaccine-preventable illnesses, and this risk is further exacerbated by immunosuppressive therapy. therefore, gastroenterologists should familiarize themselves with health maintenance measures pertaining to patients with ibd. this article highlights the vaccinations required for patients with ibd, especially those who are immunosuppre ... | 0 | 27917091 |
| preventive and therapeutic vaccines against human papillomaviruses associated cervical cancers. | cervical cancer is, globally known to be, one of the most common cancers among women especially in developing countries. more than 90% of cervical cancers are associated with high-risk human papillomaviruses (hpvs) particularly hpv types 16 and 18. two major strategies have been developed for prevention and treatment of cervical cancer and other hpv-associated malignancies; the first one is based on hpv virus-like particles (vlps) containing hpv structural proteins. vlp based vaccines can induce ... | 0 | 23493151 |
| optimizing pediatric clinical care and advocacy in an online era: report of the canadian paediatric society infectious diseases and immunization committee. | to help busy fps find useful current information and keep up to date on pediatric infectious disease and immunization topics by highlighting the work of one excellent source of reliable information in this area, the canadian paediatric society infectious diseases and immunization committee. | 0 | 25022634 |
| feasibility of cross-protective vaccination against flaviviruses of the japanese encephalitis serocomplex. | serological cross-reactivity providing cross-protective immunity between antigenically related viruses is a cornerstone of vaccination. it was the immunological basis for the first human vaccine against smallpox introduced more than 200 years ago, and continues to underpin modern vaccine development as has recently been shown for human papillomavirus vaccines, which confer cross-protection against other oncogenic papillomavirus types not present in the vaccine. here, we review the feasibility of ... | 0 | 22309667 |
| a novel intracellular antibody against the e6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models. | single-chain variable fragments (scfvs) expressed as "intracellular antibodies" (intrabodies) can target intracellular antigens to hamper their function efficaciously and specifically. here we use an intrabody targeting the e6 oncoprotein of human papillomavirus 16 (hpv16) to address the issue of a non-invasive therapy for hpv cancer patients.a scfv against the hpv16 e6 was selected by intracellular antibody capture technology and expressed as i7nuc in the nucleus of hpv16-positive siha, hpv-neg ... | 0 | 26788990 |
| [the effect of human papilloma virus extracts on rabbit endothelial explants]. | 1963 | 14064685 | |
| human papilloma virus. | 1963 | 20789694 | |
| a study of human papilloma virus dna. | 1965 | 4286353 | |
| nearest neighbour base sequence analysis of the deoxyribonucleic acids of a further three mammalian viruses: simian virus 40, human papilloma virus and adenovirus type 2. | 1967 | 4293932 | |
| electron microscope study of the denaturation of human papilloma virus dna. i. loss and reversal of supercoiling turns. | 1967 | 4293208 | |
| electron microscope study of the denaturation of human papilloma virus dna. ii. the specific location of denatured regions. | 1967 | 4293209 | |
| studies with human papilloma virus modeled after known papovavirus systems. | 1972 | 4347032 | |
| serological studies in a student population prone to infection with human papilloma virus. | four hundred and sixty-seven serum specimens from the female students at a residential college were examined for the presence of circulating antibody to human wart virus using the technique of counter-current immunoelectroosmophoresis. a significantly higher incidence of antibodies was found in students with a past history of plantar warts than in any other group. antibody took several months to develop and was detectable in 20-30% of the students up to 9 years after infection. from a few cases ... | 1972 | 4346010 |
| experiments with human papilloma virus in cell culture. | 1974 | 4373025 | |
| papovavirus structural polypeptides: comparison of human and rabbit papilloma viruses with simian virus 40. | a comparative study of the structural polypeptides of purified human papilloma virus, rabbit papilloma virus, and simian virus 40 (sv40) was performed by electrophoretic analysis on 10% polyacrylamide gels containing sodium dodecyl sulfate either by coomassie blue staining or by electrophoresing purified virus preparations labeled with radioactive iodine. analysis of human papilloma virus on stained gels revealed 6 bands with a major polypeptide of molecular weight 63,000 daltons comprising 60% ... | 1974 | 4142631 |
| persistence of viral dna in human cell cultures infected with human papilloma virus. | 1975 | 167292 | |
| human papillomavirus dna: physical map. | human papillomavirus (hpv) dna form i (supercoiled) was prepared from plantar warts. hpv dna was cleaved with restriction enzymes obtained from the following sources: escherichia coli (ecori), hemophilus influenzae strain rd (both unfractionated hind and aeparated hindii and hindiii enzymes) and hemophilus parainfluenzae (hpai). the cleavage products were analyzed by polyacrylamide gradient slab gel electrophoresis and electron microscopy. hpv dna was cleaved into two fragments by ecori (87% and ... | 1975 | 174077 |
| structural polypeptides of rabbit, bovine, and human papillomaviruses. | the number and apparent molecular weight of the structural polypeptides of shope rabbit papilloma virus (rpv), bovine papilloma virus (bpv), and human papilloma virus (hpv) were estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. up to 10 polypeptides were detected in highly purified bpv and hpv full particles; a close homology was found between the polypeptide composition of both viruses. purified rpv virions gave a similar polypeptide pattern. the main components of the thr ... | 1975 | 167184 |
| primary tissue culture of human wart-derived epidermal cells (keratinocytes). | the formation of human skin warts may depend on transformation by human papilloma virus or result from a productive virus infection. to explore this problem, methods were developed for the primary tissue culture of epidermal cells (keratinocytes) derived from wart tissues and normal skin. wart-derived keratinocytes continued to proliferate for periods exceeding 3 months, but the patterns of cell growth were identical to normal keratinocytes. electron microscopic and immunohistologic examination ... | 1975 | 164558 |
| [human papilloma virus (author's transl)]. | 1976 | 189105 | |
| failure to produce warts on human skin grafts on 'nude' mice. | split-thickness human skin was exposed to a suspension of human papilloma virus containing 10(11)-10(12) particles/ml, by immersion for varying lengths of time. it was then grafted onto the backs of congenitally athymic 'nude' mice. all grafts were accepted, but no warts developed during an observation period of up to 9 weeks. | 1976 | 779819 |
| human papilloma virus dna: physical mapping and genetic heterogeneity. | the molecular weight of three preparations of human papilloma virus dna derived from different plantar warts was determined by agarose gel electrophoresis or electron microscopic contour length measurement. it was found to amount to approximately 4.9 x 10(6). analysis of this dna after sequential digestion by four different restriction endonucleases (ecori, bam, hind ii, and hind iii) permitted physical mapping of the cleavage sites. two of the three dna preparations revealed an identical cleava ... | 1976 | 177985 |
| specific immunity in patients suffering from recurring warts before and after repetitive intradermal tests with human papilloma virus. | the specific humoral and cellular immunity of 22 patients with multiple or recurring warts was studied. after repeated intradermal tests, using an inactivated, purified viral antigen, the responses obtained could be classed into two groups. the first group (10 patients) was characterized immunologically by the acquisition of a specific cellular immunity and the appearance of circulating igg antibodies, and clinically by a total regression of resolution of the warts two to three weeks after the f ... | 1977 | 201265 |
| chromatin-like structures obtained after alkaline disruption of bovine and human papillomaviruses. | four low-molecular-weight polypeptides migrating like h2a, h2b, h3, and h4 calf liver histones were detected by sodium dodecyl sulfate-acrylamide gel electrophoresis of highly purified preparations of bovine papillomavirus (bpv) and human papillomavirus (hpv). complexes of these polypeptides and viral dna were isolated by agarose-gel filtration of the alkaline disruption products of both viruses. when observed under the electron microscope, these complexes appeared as circular structures compose ... | 1977 | 191643 |
| an in vivo study of cell-mediated immunity in human warts. preliminary results. | purified human papilloma virus (hpv) was used to study cell-mediated immunity (cmi) in patients with warts and in controls by means of the intradermal test (idt). idt was positive in 75% of patients with past history of warts, in 56% of patients presenting with warts, but in only 7% of controls. immunofluorescent antibody levels were initially low and increased after injection of hpv antigen in all groups. | 1977 | 70923 |
| in vitro-labeled dna for detecting viral genomes in multiple sclerosis: i. papovaviruses. | papovaviruses appear to be neurotropic and one, jc virus, is implicated as the cause of one type of demyelinating disease, progressive multifocal leukoencephalopathy. to investigate whether human papovaviruses play a role in multiple sclerosis, radioactively labeled dna from bk virus, human papilloma virus, and simian virus 40 was used as a probe in order to detect related unlabeled dna sequences in dna isolated from multiple sclerosis brain and/or spinal cord. labeled viral probes were denature ... | 1977 | 196234 |
| human papillomavirus dna: physical mapping of the cleavage sites of bacillus amyloliquefaciens (bami) and haemophilus parainfluenzae (hpaii) endonucleases and evidence for partial heterogeneity. | the dna of human papillomavirus (hpv) obtained from a pool of plantar warts is cleaved by bacillus amyloliquefaciens (bami) and haemophilus parainfluenzae (hpaii) restriction endonucleases at one and four specific sites, respectively. these sites were localized on the previously established cleavage map of hpv dna, using the hind, hindiii, hpai, and ecori endonuclease restriction sites as reference. the four hpaii sites were mapped, clockwise, at 1.4, 41.1, 44.3, and 52.8% of the genome length f ... | 1977 | 191644 |
| inverted repetitive sequences in human papilloma virus 1 (hpv-1) dna. | 1977 | 201085 | |
| characterization of a new type of human papillomavirus that causes skin warts. | a human papillomavirus (hpv) was isolated from the lesions of a patient (ml) bearing numerous hand common warts. this virus was compared with the well-characterized hpv found in typical plantar warts (plantar hpv). ml and plantar hpv dnas have similar molecular weights (5.26 x 10(6) and 5.23 x 10(6), respectively) but were shown to be different by restriction enzyme analysis. when the cleavage products of both dnas by endonuclease ecori, bami, hpai, or hind were analyzed by electron microscopy, ... | 1977 | 198572 |
| identification and characterization of a papillomavirus from birds (fringillidae). | from skin papillomas of the chaffinch (fringilla coelebs), a virus has been purified and studied by physicochemical techniques and electron microscopy. the virions measure 52 nm in diameter and are composed of 72 morphological units arranged in a skew t = 7d surface lattice. a sedimentation coefficient of about 300s and a buoyant density of 1.34 g/ml in cscl were determined for the particle. its protein composition resembles that of human papillomavirus, and the circular double-stranded genome m ... | 1977 | 197046 |
| identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis. | virions isolated from warts of 2 siblings with epidermodysplasia verruciformis (ev), a rare disease characterized by the lifelong growth of warty skin tumors containing papova-like virions, were compared to isolates of human papillomavirus (hpv) from 3 pools of plantar and common hand warts. the length of relaxed, circular (form ii) molecules of ev virion dna approximated the length of hpv dna but was 3.3% longer. antisera prepared in rabbits against the 3 hpv pools coated and aggregated hpv in ... | 1977 | 71354 |
| comparative study of delayed hypersensitivity skin reactions and antibodies to human papilloma virus (hpv). | 1977 | 198169 | |
| analysis of the structure of human papilloma virus dna. | human papilloma virus dna has been examined for heterogeneity by electron microscopy, reassociation kinetics, and restriction endonuclease digestion. no heterogeneity in contour length was detected. the reassociation rate of papilloma dna isolated from pooled warts was consistent with that expected for a homogeneous, unique dna of molecular weight 5 x 10(6). restriction endonuclease digestions of five papilloma dna preparations isolated from pooled warts yielded predominantly fragments of the ex ... | 1977 | 196580 |
| evidence for antigenic determinants shared by the structural polypeptides of (shope) rabbit papillomavirus and human papillomavirus type 1. | 1978 | 84435 | |
| an immunoelectron microscopic localization of wart associated antigens present in human papilloma virus (hpv) infected cells. | wart associated antigens were observed by the indirect immunoperoxidase technique in light and electron microscopy. positive reaction products could be found in the nuclei of wart cells, in which virus particles were labeled with a specific immune rabbit serum and with human sera from patients with warts. tissue antigens, differing from the viral labeled inclusions, were detected within the cytoplasm of some infected cells, by means of igm and igg antibodies from patients with warts. in these pa ... | 1978 | 205617 |
| specific immunity to human papilloma virus (hpv) in patients with genital warts. | a study of human papilloma virus (hpv) specific cellular and humoral immunity in 30 patients with genital warts is reported. by in vivo testing with purified, inactivated plantar wart virus, a cell-mediated immunity to hpv was determined in 60% of patients. circulating antibodies, evaluated by immunofluorescence testing, were rare, but these increased after an intradermal test had been carried out, especially in patients with a positive skin test, suggesting a booster effect. no significant diff ... | 1978 | 207383 |
| mastomys natalensis papilloma virus (mnpv), the causative agent of epithelial proliferations: characterization of the virus particle. | a virus (mnpv) with the structural characteristics of papilloma viruses was isolated from benign and malignant proliferations of adult animals of the inbred line 'gra giessen' of mastomys natalensis. the particles can be banded in cscl gradients at densities of 1.34 g/ml (full particles) and 1.29 g/ml (empty particles). the virus dna has a buoyant density of 1.7104 g/ml and can exist in three different conformations (supercoiled circular, nicked circular and linear), the sedimentation values of ... | 1978 | 214519 |
| immunological studies in epidermodysplasia verruciformis. | immunofluorescence and cell mediated immunity studies have been performed in 14 cases of epidermodysplasia verruciformis (ev), 3 of those abortive or regressing in members of the families of the patients with ev. two different types of human papillomavirus (hpv)--hpv3 and hpv4--have been found in cases of ev. hpv3 was detected also in flat warts without features of ev. there was no cross-reactivity between these two viruses, neither with hpv1 responsible for plantar warts nor with hpv2 inducing ... | 1978 | 212145 |
| so-called multicentric pigmented bowen's disease. report of a case and a possible etiologic role of human papilloma virus. | multicentric pigmented bowen's disease (mpbd) is a bowenoid atypia in the genitocrural region with peculiar clinical appearances. a 36-year-old japanese female patient showed a variety of lesions. clinically the lesions on the external genitalia consisted of brown-black papillomatous eruptions, black discrete or confluent papules, and whitish macerated papules. histologically only black papules showed bowenoid atypia, but whitish papules also showed transient bowenoid atypia. electron microscopi ... | 1978 | 211056 |
| characterization of human papilloma virus (h.p.v.) present in genital warts. | 1978 | 205177 | |
| seroepidemiological studies of human papilloma virus (hpv-1) infections. | at least two groups of human papilloma viruses can be distinguished serologically: on the one hand hpv 1-3, which are closely related but differ in the restriction enzyme pattern of their dna, and on the other hand hpv-4. the age distributions of patients with warts induced by hpv 1-3 or by hpv-4, respectively, differ markedly. hpv 1-3 predominates between 5 and 15 years of age, whereas hpv-4 could be isolated more often between the ages of 20-25 years. the large number of hpv-1-3-induced warts ... | 1978 | 203545 |
| [malignancies induced by human papilloma virus]. | 1978 | 214825 | |
| [warts, viruses, cancer (author's transl)]. | the malignant transformation of cutaneous lesions in epidermodysplasia verruciformis (e.v.), which lesions are caused by a human papilloma virus (hpv), can be compared to that experimentally induced by the polyoma virus. thus, hpv would undergo a lytic, transformant and/or abortive cycle in epidermal cells. in this latter case, it would increase cell dna synthesis and there would be production of cellular antigens coded by the virus. this production of cellular antigens would be the result of th ... | 1978 | 213005 |
| epidermodysplasia verruciformis versus disseminated verrucae planae: is epidermodysplasia verruciformis a generalized infection with wart virus? | recently it has been shown that epidermodysplasia verruciformis is induced by human papilloma/virus different from the papilloma/virus of warts, and that 2 distinct viruses-designated hpv-3 and hp-4--are responsible for it. ten cases of epidermodysplasia verruciformis were found to have been caused by hpv-3. clinically and histologically, as well as in the often depressed cell-mediated immunity they closely resembled long-standing verrucae planae, also caused by hpv-3. contrariwise, in epidermod ... | 1979 | 217936 |
| characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformis. | 1979 | 218721 | |
| seroepidemiologic studies of bovine papillomavirus infections. | bovine and human sera were analyzed for the presence of antibodies against bovine papillomavirus types 1 and 2 (bpv 1 and 2) and human papillomavirus type 1 (hpv 1) in a solid-phase radioimmunoassay. human sera did not react with bpv antigens, and bovine sera showed no evidence of antibodies against hpv 1. in contrast, 19% of all bovine sera tested reacted with bpv 1 and 2 antigens, and 35% of human sera revealed antibodies against hpv 1. no serologic evidence was obtained for heterologous infec ... | 1979 | 220453 |
| localization of viral dna-replication in sections of human warts by nucleic acid hybridization with complementary rna of human papilloma virus type 1. | using complementary rna of human papilloma virus type 1 (hpv1) and in situ hybridization techniques the localization of viral dna replication was studied in sections of 38 human virus acanthomata from 31 different patients. in five cases significant labeling was detected by autoradiography. labeling started always in the first or the second suprabasal cell layer and was strongly limited to the nuclei. a remarkable early beginning of the vacuolated process seemed to be correlated with the visible ... | 1979 | 220921 |
| immunology of human warts. | rapid advances have occurred in the characterization of human papilloma virus (hpv) types applying the new advanced techniques of restriction endonuclease analysis and molecular hybridization to human wart virus. human papilloma virus can no longer be viewed as a single, homogeneous virus producing all varieties of clinical warts. at least three antigenically heterogeneous hpv types have been associated with common and plantar warts. two additional hpv types have been found in patients with epid ... | 1979 | 229134 |
| conserved polynucleotide sequences among the genomes of papillomaviruses. | the dnas of different members of the papillomavirus genus of papovaviruses were analyzed for nucleotide sequence homology. under standard hybridization conditions (tm - 28 degrees c), no homology was detectable among the genomes of human papillomavirus type 1 (hpv-1), bovine papillomavirus type 2 (bpv-2), or cottontail rabbit (shope) papillomavirus (crpv). however, under less stringent conditions (i.e., tm - 43 degrees c), stable hybrids were formed between radiolabeled dnas of crpv, bpv-1, or b ... | 1979 | 232171 |
| connection between capsomeres in human papilloma virus. | 1979 | 223316 | |
| characterization of human papillomavirus 3 in warts of a renal allograft patient. | multiple flat wart-like lesions of a renal allograft recipient were shown to contain hpv 3 or a serologically crossreacting virus by indirect immunofluorescence with monospecific animal antisera against hpv [1--5]. the patient's serum revealed virus specific antibodies (immunofluorescence titer 1/80). papillomaviruses were isolated and after in vitro iodination 3 major proteins (mw 70.000, 56.000 and 43.000) were detected by sds polyacryalmide gel electrophoresis. dna was extracted from the wart ... | 1979 | 227966 |
| anogenital warts contain several distinct species of human papillomavirus. | anogenital warts from 26 patients were examined for the presence of human papillomavirus (hpv). although no whole, intact virus could be identified, varying amounts of nonintegrated hpv dna were detected in 18 tissue specimens (70%) by employing both an agarose gel-ethidium bromide staining method and the southern blot hybridization procedure. when hybridization analysis was performed under stringent conditions, six anogenital warts were observed to contain hpv genomic sequences related to eithe ... | 1980 | 6255208 |
| epithelial lesions suggestive of a condylomatous origin found closely associated with invasive bronchial squamous cell carcinomas. | the histology of the bronchial specimens derived from 104 patients with an established invasive bronchial squamous cell carcinoma was assessed with special reference to the detection of the morphological manifestations of human papilloma virus (hpv) recently described in the uterine cervix, i.e., three different types of condylomatous lesions (papillomatous, flat and endophytic). histological lesions fulfilling the criteria of papillomatous condyloma were found in 6 cases, those of endophytic co ... | 1980 | 6255522 |
| immunoperoxidase localization of human papillomavirus in laryngeal papillomas. | five antigenically distinct serotypes of human papillomavirus (hpv) cause various cutaneous verrucae with distinct clinical features. laryngeal and other mucosal papillomas, also suspected to have a viral etiology, were examined for the presence of a genus-specific (common) antigen of hpv using a peroxidase-antiperoxidase (pap) technique. the primary antiserum used was reactive against laryngeal papillomas from 26 of 35 randomly selected patients (74%); overall, 49 of the 102 squamous papilloma ... | 1980 | 6263818 |
| uv-induced dna repair synthesis in patients with epidermodysplasia verruciformis. | autoradiographic technique was utilized to measure uv-induced dna repair synthesis in 8 patients with epidermodysplasia verruciformis: 2 infected with human papillomavirus 3 (hpv 3), 4 with hpv 4, and 2 simultaneously with hpv 3 and hpv 4. two cell populations were compared, i.e., epidermal cells derived from light-exposed and covered skin, and peripheral lymphocytes. a control group consisted of 10 healthy subjects. dna repair was found to be normal both in the peripheral lymphocytes and in the ... | 1980 | 6244993 |
| oral retinoid treatment of human papillomavirus type 5-induced epidermodysplasia verruciformis. | 1980 | 6245361 | |
| noncondylomatous cervical wart virus infection. | human papillomavirus (hpv) infections of the genital tract frequently involve cervical epithelium and produce a macroscopically flat lesion that the authors have called noncondylomatous cervical wart virus infection (ncwvi). over a 6-month period, 92 of 7281 routine cervical smears (1.3%) and 46 of 183 colposcopically directed punch biopsies (25%) showed morphologic evidence of wart virus infection. the etiologic role of hpv was confirmed by the demonstration of virus particles in 24 of 53 cases ... | 1980 | 6245394 |
| immune reactions in epidermodysplasia verruciformis. | serum antibodies against human papilloma virus have been measured using immunodiffusion and enzyme linked immunosorbent assay in twelve patients with epidermodysplasia verruciformis (ev). the results were compared with those from sixty-six patients with other types of human papilloma virus diseases. antibody prevalences were slightly lower in patients with ev than in the control patients. more remarkable was the difference between ev patiens and control subjects in tests of non-specific cell-med ... | 1980 | 6245674 |
| partial characterization of viral dna from human genital warts (condylomata acuminata). | by centrifuging total cellular dna derived from human genital warts (condylomata acuminata) in cscl-ethidium bromide gradients, supercoiled dna was isolated. the molecular weight of this dna was determined by agarose gel electrophoresis and amounted to 5.1 x 10(4). this dna isolated from an individual genital wart was annealed to fractions of aqueous supernatants of the same wart after prior centrifugation of this material in cscl density gradients. annealing was observed at a density of approxi ... | 1980 | 6246010 |
| molecular cloning, refined physical map and heterogeneity of methylation sites of papilloma virus type 1a dna. | the entire genome of human papilloma virus type 1a was cloned in escherichia coli using the plasmid pbr322 as vector. the integrity and the homogeneity of the viral dna thus obtained was confirmed by restriction endonucleases analysis. viral dna isolated from a single wart was partially methylated at only one out of the four hpaii sites, d(c-c-g-g). recognition sites for bg/i, bg/ii, psti and pvuii restriction endonucleases were located on the cloned genome. | 1980 | 6250842 |
| a potentially oncogenic human papillomavirus (hpv-5) found in two renal allograft recipients. | we have observed 2 immunosuppressed renal allograft recipients with skin lesions induced by human papillomavirus type 5 (hpv-5). one recipient had multiple pityriasis versicolor-like (pv-like) skin lesions on his arms and trunk, and multiple bowenoid in-situ skin cancers. the other had 2 warty lesions on the back of her fingers. structural antigens of human papillomavirus type 5 (hpv-5) were identified in benign lesions from both patients by immunofluorescence. the histologic and ultrastructural ... | 1980 | 6253573 |
| cloning of human papilloma virus genomic dnas and analysis of homologous polynucleotide sequences. | the complete dna genomes of four distinct human papilloma viruses (human papilloma virus subtype 1a [hpv-1a], hpv-1b, hpv-2a, and hpv-4) were molecularly cloned in escherichia coli, using the certified plasmid vector pbr322. the restriction endonuclease patterns of the cloned hpv-1a and hpv-1b dnas were similar to those already published for uncloned dnas. physical maps were constructed for hpv-2a dna and hpv-4 dna, since these viral dnas had not been previously mapped. by using the cloned dnas, ... | 1980 | 6253665 |
| relationship between condylomata and laryngeal papillomata. clinical and molecular virological evidence. | in a survey of 49 papilloma patients accurate maternal condyloma history was obtained in 31 instances and of these, 21 were positive for the presence of condyloma during pregnancy or parturition. molecular virological studies indicate that positive hybridization could be demonstrated to human papilloma virus 2 in both laryngeal papilloma and condyloma by the southern blot technique. immunoperoxidase staining illustrated the presence of virus-related particles only near the surface of the mucous ... | 1980 | 6254426 |
| [epidermodysplasia verruciformis (2 cases). immunological study (author's transl)]. | flat wart-like lesions of two patients with epidermodysplasia verruciformis (edv) were associated with pink, tan or depigmented pityriasis-like macules. there was no familial history nor mental retardation. human papilloma virus (hpv) type 5 was demonstrated in the two patients and was responsible for the pityriasis-like lesions. malignancies seem to be closely related to hpv-5 infection since bowenoid transformation occurred in the 2 patients. immunological studies showed an increase of serum i ... | 1980 | 6254427 |
| immunohistochemical localisation of human papillomavirus in squamous papillomas of the larynx. | 1980 | 6106769 | |
| human papilloma virus infection of the uterine cervix. | 1980 | 6243835 | |
| condylomatous lesions of the uterine cervix with special reference to squamous cell carcinogenesis. | 528 women with either a dysplastic or a neoplastic change in the squamous epithelium of the uterine cervix were histologically assessed with special emphasis on the detection of the newly discovered condylomatous lesions (flat, inverted and papillomatous). a total of 289 condylomatous (co) lesions were found, the flat being most frequent (78.9%) followed by the inverted (14.5%) and the papillomatous ones (6.6%). the mean age (31.8 years) of the women with co lesions was significantly lower (p le ... | 1980 | 7227865 |
| condylomatous lesions associated with precancerous changes and carcinomas of the uterine cervix. | the present communication is a comparative survey of the histological specimens derived from the dysplastic or neoplastic lesion of the uterine cervix of 400 women comprising two age-matched series (200 women in each) collected from two finnish hospitals. special emphasis was placed on the detection of the newly described condylomatous lesions (flat, inverted, papillomatous) and the possible variations in their biological behavior in the two series. the biological behavior of the condylomatous l ... | 1981 | 7290270 |
| an unusual wart-like skin lesion found in a renal allograft recipient. | immunosuppressed renal allograft recipients have an increased tendency to acquire warts. while studying such patients, we found a virus-induced, wart-like lesion that had an unusual histologic picture. light microscopic studies showed bizarre keratinocytes with cytoplasmic, juxtanuclear, giant, crescentic bodies and round, nuclear inclusions, by electron microscopy, the giant cytoplasmic bodies were found to be composed of tonofilaments, and the nuclear inclusions were found to be composed of pa ... | 1981 | 7006517 |
| origin of the koilocyte in condylomata of the human cervix: ultrastructural study. | twelve biopsies from condylomatous lesions of the human cervix were examined by transmission electron microscopy in order to study koilocytotic cells. the ultrastructure of koilocytes, revealed mainly cytoplasmic changes in the perinuclear area. these changes first appeared in cells of the intermediate layers and extended to the surface of the epithelium. the cells involved showed small perinuclear areas, with a fine granular material, which appeared as a lysis of the cytoplasmic matrix, forming ... | 1981 | 6945004 |
| human papillomavirus infection of the cervix: the atypical condyloma. | we report on 162 cases of human papillomavirus (hpv) infection of the cervix seen in a two-year period in which the cell sample showed such marked atypia that errors of interpretation could easily have been made. these atypical condylomata are difficult to diagnose cytologically as well as histologically because they mimic dysplasia or carcinoma in situ and, on smears, even invasive squamous carcinoma. hpv particles associated with fibrillar material were found within nuclei of these lesions; th ... | 1981 | 6258367 |
| presence of human papilloma viral antigens in juvenile multiple laryngeal papilloma. | juvenile laryngeal papillomas, solitary laryngeal papillomas of the adult, and cylindric cell papillomas of the nose and sinuses were examined for the presence of papillomavirus antigens by means of immunocytochemistry. by using an antiserum capable of recognizing a common group antigen that reacts with papillomavirus antigens of different species, it was found that half of the juvenile laryngeal papillomas studied contained cells staining for papillomavirus antigens. no positive cells were foun ... | 1981 | 6258422 |
| analysis of human cancers, normal tissues, and verruce plantares for dna sequences of human papillomavirus types 1 and 2. | 1981 | 6259829 | |
| t cell defect in patients with epidermodysplasia verruciformis due to human papillomavirus type 3 and 5. | most of the patients with epidermodysplasia verruciformis (ev) were anergic to sensitization to dinitrochlorobenzene (dncb) and were shown to have a decreased number of t lymphocytes and reduced lymphocyte pha responsiveness. preserved cell-mediated immunity (cmi) was found only in the abortive cases of ev infected with human papillomavirus type 3 (hpv-3). cmi was impaired to the same extent in patients with ev induced by hpv-3 and hpv-5, and in ev cases with combined infection with both viruses ... | 1981 | 6265297 |
| identification of papillomaviruses in butchers' warts. | we have studied the papillomaviruses found in the hand warts of 60 butchers, most of them from 2 distant slaughterhouses. warts differing in morphology and location were studied separately. the viruses were identified by molecular hybridization, restriction enzyme analysis and immunofluorescence. four known human papillomaviruses (hpv-1, hpv-2, hpv-3, hpv-4) were detected and one hitherto unknown papillomavirus was identified in 9 butchers. the dna of the latter virus did not anneal with any of ... | 1981 | 6257792 |
| condylomata of the uterine cervix and koilocytosis of cervical intraepithelial neoplasia. | in 202 women with koilocytotic atypia in cervical smears, 136 had predominantly small condylomata of the uterine cervix, and 66 had cervical intraepithelial neoplasia (cin) of varying degree either with koilocytosis of the neoplasia or associated with condylomata. koilocytosis correlated well with the histological diagnosis of condylomata, but occasionally it obscured the cytological evidence of cin. human papilloma virus particles were found in the cells of condylomata in 10 cases and in those ... | 1981 | 6265503 |
| histological evidence for the presence of condylomatous epithelial lesions in association with laryngeal squamous cell carcinoma. | the laryngeal specimens obtained from 116 patients with established invasive squamous cell carcinoma of the larynx were histologically assessed with special reference to the detection of morphological manifestations of human papilloma virus (hpv), as newly described in the uterine cervix, i.e. the three different types of condylomas (the papillomatous, the flat and the inverted ones). epithelial changes fulfilling the criteria of the papillomatous condyloma were found in 15 cases, those of the i ... | 1981 | 6265845 |
| human papillomavirus and cancer of the uterine cervix. | 1981 | 6273260 | |
| association of human papillomavirus with neoplastic processes in the genital tract of four women with impaired immunity. | 1981 | 6273262 | |
| molecular cloning of viral dna from human genital warts. | the dna of human papilloma virus type 6 (hpv 6) has been cloned in escherichia coli k-12 by using pbr322 as vector. the dna was cloned at the bamhi and ecori cleavage sites. this dna was mapped by employing further restriction endonucleases and by terminal labeling. no major differences were noted as compared to hpv 6 dna originating directly from a genital wart. the existence of at least two dna subtypes (hpv 6a and 6b) became apparent. | 1981 | 6275126 |
| human papilloma virus type i purified from human genital warts. | human wart virus (hpv) was isolated from a pool of genital warts. the electrophoretic mobility of virion proteins was studied by sds polyacrylamide gel electrophoresis and showed the same pattern as that obtained with hpv-1. the analysis of dna after restriction enzyme digestion with the endonucleases hind iii and hae iii, and nucleic acid hybridization did not show any difference with hpv-1. the viral particles were agglutinated by anti-hpv-1 serum, as shown by electron microscopic particle agg ... | 1981 | 6266889 |
| identification of a novel human papilloma virus in cutaneous warts of meathandlers. | 1981 | 6267773 | |
| characterization of a human papillomavirus from epidermodysplasia verruciformis lesions of a patient from upper-volta. | a case of epidermodysplasia verruciformis in a patient from upper-volta is described. slightly elevated, flat warts were observed on hands, feet, arms and legs, and pityriasis versicolor-like lesions were found mainly on the trunk. the patient showed no malignant tumors. histological examination revealed hyperkeratosis, granulosis and moderate acanthosis with large, foamy, basophilic keratinocytes in stratum granulosum and stratum spinosum. papillomavirus particles could be prepared from these l ... | 1981 | 6270020 |
| vaginal condylomata: a human papillomavirus infection. | in our clinic, as a rule, we do not treat vaginal condylomata. they are usually subclinical and asymptomatic. when atypia is present on biopsy, they should be treated in the same manner as vaginal intraepithelial neoplasia. when vaginal discharge and pruritus are present, infection should be searched for and treated. when condylomata are seen with the naked eye, colposcopy has shown that there were many more, too small to be seen, so that local therapy seems a waste of time. if on colposcopic ex ... | 1981 | 6273036 |
| human papillomavirus (hpv) in condylomatous lesions of cervix. | ninety-seven cervical condylomata classified histologically as flat condyloma (planum), papillary condyloma (acuminatum), and endophytic condyloma were studied by transmission electron microscopy (tem) and by immunoperoxidase technique (ipt) for the presence of human papillomavirus (hpv) particles and antigen, respectively. both techniques localized hpv chiefly in nuclei of koilocytotic cells. hpv particles were found in 25% of the cases by tem and hpv antigen was detected in 48% of the cases by ... | 1981 | 6278970 |
| genital warts. | human papillomaviruses have not been propagated in tissue culture, so they cannot be studied by the procedures of classical virology. recently, dna hydridization techniques and restriction enzyme analysis have revealed that multiple strains of human papillomaviruses exist. it is now accepted that genital warts are a sexually transmitted disease; other routes of infection are possible, but unusual. an association between maternal warts during pregnancy and the development of vulval warts and lary ... | 1981 | 6277022 |
| [condylomata acuminata]. | condylomata acuminata are benign epitheliomas which are caused by the human papilloma virus. 8 subgroups (variants) of the virus are known up to now. condylomata acuminata are infectious, the virus being transferred by direct contact with a lesion. condylomata acuminata are found more often in males than in females and never occur in children prior to the age of two years. the peak incidence is between 19 and 22 years of age. greatly proliferating condylomata acuminata (type buschke-löwenstein) ... | 1981 | 6281993 |
| [human papillomavirus and oncogenesis (author's transl)]. | various types of human papillomavirus (hpv) are responsible for different warts. characteristic of hpv infections is a lowered cell-mediated immunity (cmi), especially defective in cases of epidermodysplasia verruciformis induced by hpv5. the malignant transformation seems to be related with the type of hpv, and not with the grade of cmi defect and duration of the infection. a life-long infection with hpv3 in cases of ev does not induce a malignant transformation in spite of heavily depressed cm ... | 1982 | 6283752 |
| different papillomaviruses as the causes of oral warts. | we have observed four patients with oral papillomas. two children had oral mucosal lesions characteristic of focal epithelial hyperplasia, a young man had common, wart-like lesions on his hard palate, and a male immunosuppressed renal allograft recipient had condyloma-like lesions on his gingivae. papillomavirus-like particles were seen by electron microscopy in lesions from both patients with focal epithelial hyperplasia. no structural antigens for human papillomavirus (hpv) 1, 2, 3, or 5 were ... | 1982 | 6284061 |
| human papilloma viral dna replicates as a stable episome in cultured epidermal keratinocytes. | human papilloma virus (hpv) is poorly understood because systems for its growth in tissue culture have not been developed. we report here that cultured human epidermal keratinocytes could be infected with hpv from plantar warts and that the viral dna persisted and replicated as a stable episome. there were 50-200 copies of viral dna per cell and there was no evidence to indicate integration of viral dna into the cellular genome. there was also no evidence to suggest that viral dna underwent prod ... | 1982 | 6285348 |
| isolation of a human papillomavirus from a patient with epidermodysplasia verruciformis: presence of related viral dna genomes in human urogenital tumors. | the dna genome of a human papillomavirus (hpv), tentatively designated hpv-ev, was molecularly cloned from hand to leg lesions of a patient with epidermodysplasia verruciformis, a chronic skin disease associated with a 30% risk of developing cancer. using stringent hybridization conditions, we observed less than 5% homology between hpv-ev and the cloned genomes of hpv-1, hpv-4, hpv-5, and hpv-5a. hpv-ev dna showed approximately 6% homology with hpv-2 and 36% homology with hpv-3. these data sugge ... | 1982 | 6289302 |
| human papilloma virus infection (condyloma) of the uterine cervix in japanese women. | 1982 | 6290429 | |
| human papillomavirus. frequency and distribution in plantar and common warts. | fifty-nine (24 plantar, 35 common) warts surgically excised from 44 patients (15 female, 29 male), 18 to 32 years old, were examined by electron microscopy (em) for papillomavirus particles and by fluorescent antibody (fa) and peroxidase-antiperoxidase (pap) tests for human papillomavirus type 1 (hpv-1)-specific antigens and papillomavirus genus-specific (common) antigens. fifty per cent of plantar warts and 52 per cent of common warts were positive for hpv by em. when examined by fa and pap for ... | 1982 | 6290785 |
| two anatomoclinical types of warts with plantar localization: specific cytopathogenic effects of papillomavirus. type i (hpv-1) and type 2 (hpv-2). | in this study, the clinical and histopathological aspects of 50 plantar warts are reported in relation to the type of papillomavirus present in the lesions, as detected by immunofluorescence tests, using specific guinea pig fluorescein-labelled igg. warts of plantar localization are not caused by the same human papillomavirus (hpv) since they are found to be associated with both hpv type 1 (hpv-1) and hpv type 2 (hpv-2). hpv-1 is always associated with deep and painful plantar warts (myrmecia), ... | 1982 | 6299203 |
| epidermodysplasia verruciformis induced by a new human papillomavirus (hpv-8). report of a case without immune dysfunction. effect of treatment with an aromatic retinoid. | a new case of epidermodysplasia verruciformis (ev) is reported in a 35-year-old man characterized by multiple common warts, flat warts, psoriasis-form lesions, and pityriasis-versicolor-(pv) like lesions. there was no familial history, no mental retardation, and no malignant changes. human papilloma virus type 8 was identified in pv-like lesions. immunologic studies detected no abnormalities: delayed skin tests, dncb sensitization, levels of immunoglobulins, complement components, circulating im ... | 1982 | 6299205 |
| immunoperoxidase demonstration of human papilloma virus (hpv) in dysplastic lesions of the uterine cervix. | routinely processed sections of 47 unselected cervical dysplasias and in situ carcinomas (both condylomatous, co, and noncondylomatous, nco) were subjected to staining with indirect immunoperoxidase-pap technique using anti-human papilloma virus (anti-hpv) immune serum to demonstrate hpv antigens in these lesions. anti-hpv was raised in guinea pigs immunized with highly purified virions from a pool of human skin wart tissues. positive reactivity for hpv (brown intranuclear precipitates) was disc ... | 1982 | 6299212 |
| analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 dna. | 32p-labelled cloned hpv 6 dna was used as probe to analyze human genital tumors for dna sequences homologous to hpv 6 dna. ninety three percent of all condylomata acuminata (41 out of 44) were found to harbor hpv 6 dna. of the remaining three, one contained hpv 1 dna. no papillomavirus dna was identified in the two other tumors. all three invasively growing giant condylomata acuminata (buschke-löwenstein tumors) investigated also contained hpv 6 dna. two out of six atypical condylomata of the ce ... | 1982 | 6277807 |
| infections by human papillomavirus (warts). | 1982 | 6282150 |