| genetic relationship between thirteen genome types of adenovirus 11, 34, and 35 with different tropisms. | eleven genome types of adenovirus serotype 11 (ad11) were identified among 20 strains isolated from healthy pregnant women and patients with urinary tract infections, respiratory tract infections, or pharyngoconjunctival fever by use of 13 restriction endonucleases: bamhi, bcli, bgli, bglii, bsteii, ecori, hindiii, hpai, psti, sali, smai, xbai, and xhoi. all genome types could be grouped into three genomic clusters according to their genetic homology expressed as pairwise comigrating restriction ... | 1991 | 1657824 |
| characterizing clearance of helper adenovirus by a clinical raav1 manufacturing process. | recombinant adeno-associated viral vectors (raav) are being developed as gene therapy delivery vehicles and as genetic vaccines, and some of the most scaleable manufacturing methods for raav use live adenovirus to induce production. one aspect of establishing safety of raav products is therefore demonstrating adequate and reliable clearance of this helper virus by the vector purification process. the ich q5a regulatory guidance on viral safety provides recommendations for process design and char ... | 2008 | 17644406 |
| molecular viral epidemiology and clinical characterization of acute febrile respiratory infections in hospitalized children in taiwan. | acute respiratory infection (ari) is a leading cause of morbidity and hospitalization in children. to profile the viruses causing ari in children admitted to a community-based hospital in central taiwan, a cross-sectional study was conducted on children under 14 years of age that were hospitalized with febrile ari. viral etiology was determined using conventional cell culture and a commercial respiratory virus panel fast assay (xtag rvp), capable of detecting 19 different respiratory viruses and ... | 2015 | 26089293 |
| the role of viruses in the pathogenesis of peritonsillar abscess. | peritonsillar abscess (pta) is the most frequent complication of acute tonsillitis and a prevalent cause for acute admission to otorhinolaryngology departments. our aim was to examine the role of viruses in the pathogenesis of pta, as this has not previously been considered. we examined both palatine tonsils from 25 patients undergoing acute tonsillectomy for pta, using pcr-based assays for herpes simplex virus-1 and -2 (hsv-1 and -2), adenovirus, epstein-barr virus (ebv), influenza a and b, and ... | 2012 | 22373896 |
| electrostatic interactions between complement regulator cd46(scr1-2) and adenovirus ad11/ad21 fiber protein knob. | adenoviruses bind to a variety of human cells to cause infection. both the b2 adenovirus 11 and b1 adenovirus 21 use protein knobs to bind to complement regulator cd46(scr1-2) in order to gain entry into host cells. in each complex, the two proteins are highly negatively charged but bind to each other at an interface with oppositely charged surface patches. we computationally generated single-alanine mutants of charged residues in the complexes cd46(scr1-2)-ad11k and cd46(scr1-2)-ad21k. we used ... | 2015 | 26357573 |
| nitric oxide metabolites as biomarkers for influenza-like acute respiratory infections presenting to the emergency room. | nitric oxide (no) is increased in the respiratory tract in pulmonary infections. the aim was to determine whether nasal wash no metabolites could serve as biomarkers of viral pathogen and disease severity in children with influenza-like illness (ili) presenting to the emergency department (ed) during the 2009 influenza a h1n1 pandemic. | 2012 | 23166571 |
| modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11. | oncolytic adenoviruses based on serotype 5 (ad5) have several shortcomings, including the downregulation of its receptor in cancer cells, high prevalence of neutralizing antibodies and hepatotoxicity. another adenoviral serotype, ad11, could overcome these obstacles. here, we show that human cancer cell lines express higher levels of the ad11 receptor cd46, resulting in much better infectivity than ad5. surprisingly, only 36% (9/25) of the cell lines were more sensitive to ad11- than to ad5-medi ... | 2011 | 22086234 |
| aetiology of upper respiratory tract infections in children in arak city: a community based study. | viruses are frequent causes of upper respiratory tract infections in children. we investigated the viral aetiology of community-acquired upper respiratory tract infections (uris) in young children treated as outpatients in community settings.during november 2008, nasal swab specimens were taken from children with recent onset of upper respiratory tract infections. the patients attended day care or primary schools; the specimens were randomly obtained by pediatricians from schools and childcare i ... | 2011 | 22207287 |
| structure of the extracellular portion of cd46 provides insights into its interactions with complement proteins and pathogens. | the human membrane cofactor protein (mcp, cd46) is a central component of the innate immune system. cd46 protects autologous cells from complement attack by binding to complement proteins c3b and c4b and serving as a cofactor for their cleavage. recent data show that cd46 also plays a role in mediating acquired immune responses, and in triggering autophagy. in addition to these physiologic functions, a significant number of pathogens, including select adenoviruses, measles virus, human herpes vi ... | 2010 | 20941397 |
| adenovirus 11p downregulates cd46 early in infection. | adenovirus 11 prototype (ad11p), belonging to species b, uses cd46 as an attachment receptor. cd46, a complement regulatory molecule, is expressed on all human nucleated cells. we show here that ad11p virions downregulate cd46 on the surface of k562 cells as early as 5min p.i. specific binding to cd46 by the ad11p fiber knob was required to mediate downregulation. the complement regulatory factors cd55 and cd59 were also reduced to a significant extent as a consequence of ad11p binding to k562 c ... | 2010 | 20638094 |
| genomic analyses of recombinant adenovirus type 11a in china. | whole-genome sequencing of human adenovirus type 11 (hadv-11) strain qs, isolated in china, was conducted, and its sequence was compared with the sequences of strains within the species of hadvs. the hadv-11 qs genome contains 34,755 nucleotides. similar to the other hadv subgenus b sequences, the hadv-11 qs genome coded 37 functional proteins and could be divided into four early, two intermediate, and five late transcription regions. the amino acid sequences of the fiber and the hypervariable r ... | 2009 | 19675212 |
| [etiology of pneumonia in hospitalized patients less than 3 years of age]. | to understand the etiology of pneumonia in hospitalized patients less than 3 years of age. | 2008 | 18433531 |
| serodiagnosis of acute respiratory infections in children in georgia. | to investigate the etiology of acute respiratory infections in hospitalized children. | 2006 | 16877849 |
| development and assessment of human adenovirus type 11 as a gene transfer vector. | adenovirus vectors based on human serotype 5 (ad5) have successfully been used as gene transfer vectors in many gene therapy-based approaches to treat disease. despite their widespread application, many potential therapeutic applications are limited by the widespread prevalence of vector-neutralizing antibodies within the human population and the inability of ad5-based vectors to transduce important therapeutic target cell types. in an attempt to circumvent these problems, we have developed ad v ... | 2005 | 15795294 |
| successful cidofovir treatment of adenovirus-associated hemorrhagic cystitis and renal dysfunction after allogenic bone marrow transplant. | we present a patient who developed hemorrhagic cystitis and renal dysfunction after unrelated bone marrow transplantation. polyoma bk virus and adenovirus 11 were detected in the urine. vidarabine was administered without effect. relatively low dose cidofovir was efficacious. renal function improved, and the urinary secretion of adenovirus stopped. | 2003 | 14579818 |
| comparative analysis of the genome organization of human adenovirus 11, a member of the human adenovirus species b, and the commonly used human adenovirus 5 vector, a member of species c. | adenovirus type 11 (ad11), a member of the human adenovirus species b (hadv-b), has a tropism for the urinary tract. the genome of ad11 was found to comprise 34 794 bp and is 1141 bp shorter than the ad5 genome of species hadv-c. the g+c content of the ad11 genome is 48.9 %, whereas that of ad5 is 55.2 %. ad11 and ad5 share 57 % nucleotide identity and possess the same four early regions, but the e3 region of ad11 could not be divided into e3a and e3b. the late genes of ad11 and ad5 are organize ... | 2003 | 12867636 |
| the complete nucleotide sequence, genome organization, and origin of human adenovirus type 11. | the complete dna sequence and transcription map of human adenovirus type 11 are reported here. this is the first published sequence for a subgenera b human adenovirus and demonstrates a genome organization highly similar to those of other human adenoviruses. all of the genes from the early, intermediate, and late regions are present in the expected locations of the genome for a human adenovirus. the genome size is 34,794 bp in length and has a gc content of 48.9%. sequence alignment with genomes ... | 2003 | 12726735 |
| [typing of enteric adenoviruses in feces of infants with diarrhea]. | to study the infection condition of adenovirus types in infants with diarrhea in shenzhen. | 2000 | 11498698 |
| acute follicular conjunctivitis caused by adenovirus type 34. | adenovirus type 34 belongs to adenovirus subgenus b. the prototype virus of adenovirus 34 was isolated from a renal transplant recipient. however, no case of acute conjunctivitis caused by adenovirus 34 has been reported. recently, we encountered two cases of acute follicular conjunctivitis in which adenovirus 34 was isolated. | 1999 | 10612502 |
| fatal disseminated adenovirus 11 pneumonia in an agammaglobulinemic patient. | adenovirus type 11, an organism not previously associated with pneumonia, caused the death of a patient with infantile x-linked agammaglobulinemia who had normal cell-mediated immunity. despite long-standing, regular therapy with immune globulin, his serum lacked neutralizing antibody to the virus. this case confronts the conventional view that viral infections are primarily resisted by cellular immune reactions and reemphasizes the importance of antibody in the host defense against adenoviruses ... | 1981 | 6274190 |
| adenovirus multiplication: inhibition by methisazone. | methisazone (5 to 40 microm) inhibited the multiplication of types 3, 7, 9, 11, 14, 16, 17, 21, and 28 adenovirus; sv15 (a simian adenovirus) was also inhibited. a study of adenovirus 11 under single-cycle conditions showed that multiplication of the virus, was completely inhibited by 30 microm methisazone when addition of the compound was delayed until 13 hours after infection. a survey showed that the structure-activity relations of the action of methisazone against adenoviruses and pox viruse ... | 1966 | 5919452 |
| characterization by hemagglutination-inhibition of adenovirus 11 strains from urine of patients with hemorrhagic cystitis. | | 1973 | 4737045 |
| acute hemorrhagic conjunctivitis: a mixed virus outbreak among vietnamese refugees on guam. | in may 1975 the authors investigated an outbreak of acute hemorrhagic conjunctivitis that affected an estimated 29,000 refugees from south vietnam who stayed on guam while en route to the united states. illness usually lasted6-10 days and was characterized by conjunctival injection (100%), lid edema (84%), eye irritation (81%) and subconjunctival hemorrhages (45%). conjunctival swabs and paired serum specimens on a limited number of patients implicated enterovirus 70 as a major etiologic agent ... | 1977 | 188334 |
| a review of adenoviruses in the etiology of acute hemorrhagic cystitis. | in a comparison of children with acute hemorrhagic cystitis it was noted that 51 per cent of those in sendai, japan and 23 per cent of those in chicago, illinois had adenoviruria during their illness. these 2 populations are the only ones in which the disease has been studied and reported. in both populations male outnumbered female patients, with a ratio of 3.4 to 1 in japanese children and 2.3 to 1 in american children. adenovirus type 11 was isolated exclusively in both studies, with the exce ... | 1976 | 175174 |
| the first complete genome sequence and pathogenicity characterization of fowl adenovirus 11 from chickens with inclusion body hepatitis in pakistan. | inclusion body hepatitis (ibh), hydropericardium syndrome, and gizzard erosion associated with fowl adenovirus (fadv) infections are reported globally and resulted in significant poultry industry economic losses. in 2018, severe ibh appeared in pakistan in a 17-week-old layer flock. subsequently, a fadv-11 strain (designated as pkfad18) was isolated from liver samples and identified based on phylogenetic analyses of the serotype-specific l1 region of the capsid hexon gene. there is no complete g ... | 2020 | 32402334 |