| causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage. | the clinical course and causes of death in 132 consecutive patients with fulminant hepatic failure and grade iii or iv encephalopathy have been reviewed. 105 patients died and in 96 of these an autopsy examination was performed. in 36 patients there was cerebral oedema and the mean age of this group was significantly younger than the other fatal cases. in 28 patients death was attributed to major haemorrhage which originated in the gastrointestinal tract in 25. the prothrombin time ratio was not ... | 1975 | 172938 |
| immunodeficiency to hepatitis b virus infection and genetic susceptibility to development of hepatocellular carcinoma. | the high frequency of hepatitis b antigen (hbsag) in hepatocellular carcinoma (hcc) patients has led to the hypothesis that immunoresponsiveness to hepatitis b virus (hbv) may be deficient in some patients, and that the immune response deficiency may have a genetic basis. radioelectrocomplexing (rec), a radioimmunoassay in gel based on the principle of counterimmunoelectrophoresis (cie), has been used to identify four hbv immune status subgroups: 1) hbsag +ve/hbsab +ve; 2) hbsag +ve/hbsab -ve; 3 ... | 1975 | 173228 |
| the growth of knowledge about a disease: hepatitis. | | 1979 | 224700 |
| etiology of liver disease in renal-transplant patients. | the etiology of 72 episodes of liver disease that developed in 62 of 162 renal-transplant recipients was evaluated. infection with hepatitis b virus was a minor problem, and none of our patients had evidence of infection with hepatitis a. cytomegalovirus infection was ubiquitous in the population and probably accounted for many episodes of acute liver disease. this agent's role in causing chronic hepatitis is less secure. infections with other viruses including epstein-barr virus, adenovirus, an ... | 1979 | 224742 |
| a solid-phase radioimmunoassay for detection of igm antibodies to hepatitis a virus. | the conditions for a sensitive and specific solid-phase radioimmunoassay (ria) for the detection of igm antibodies to hepatitis a virus (hav) were optimized, and the ria was used to assay sera from patients with hepatitis. igm antibodies to hav reached highest concentrations between one and three weeks after onset of icterus and were measurable in follow-up sera for at least 12 months after infection. to prove the specificity, the igg antibodies were separated from patient sera by sucrose densit ... | 1979 | 225390 |
| [discovery of hepatitis virus]. | | 1979 | 225395 |
| [hbs ag-positive hepatocellular cancer (pathomorphologic study)]. | pathomophological and histochemical analysis of 7 autopsy cases of primary hepatocellular carcinoma was performed. direct immunofluorescence with an anti-hbsag serum and staining with orsein according to shikata's method revealed the presence of hbsag in hepatocytes of the cirrhotic tissue and in tumour cells. cirrhotic nodes were found to have numerous hbsag-positive cells, whereas in the tumour tissue the number of such cells was insignificant and they were found only in highly differentiated ... | 1979 | 226040 |
| serologic markers of hepatitis a and b in acute and chronic liver disease. | | 1979 | 226813 |
| line cell saga - an argument in favor of production of biologics in cancer cells. | | 1979 | 227236 |
| viral vaccines under development: a third generation. | in summary then, my purpose has been two-fold: on the one hand, i have tried to highlight the kinds of basic science advances in both cellular and virologic research that can (and should) be focussed both on vaccines under development and, retrospectively, on those whose origins were strictly empiric. on the other hand, i have attempted a partial survey of some of the prominent members of a potential new generation of vaccines to point out areas where these advances can and should contribute eit ... | 1979 | 227237 |
| emerging patterns of hepatitis b chronic liver disease in australia. | until now, the hepatitis b virus has been thought to play a minor role in the aetiology of chronic liver disease in australia. this is a report of 21 patients with cirrhosis and/or primary hepatocellular carcinoma with hepatitis b antigenaemia. primary hepatocellular carcinoma occurred in six patients, five of whom had underlying cirrhosis. the disease occurred mainly in non-australian born males, and was not often associated with a previous history of hepatitis. the death of 16 patients within ... | 1979 | 228647 |
| evidence for clustering of hepatitis b virus infection in families of patients with primary hepatocellular carcinoma. | family member of 13 patients with hepatitis b surface antigen (hbsag) positive primary hepatocellular carcinoma (phc) were tested for the presence of hepatitis b virus-associated antigens and antibodies. of the 122 members examined, circulating hgsag was detected in 47 (39%), antibody to hbsag (anti-hbs) was found in 37 (30%), and antibody to hepatitis b core antigen (anti-hbc) alone was present in 13 (11%). the relatives with the highest frequency of hbsag positivity were the offspring of the p ... | 1979 | 228843 |
| acute viral hepatitis. | | 1976 | 173971 |
| a comparative study of hepatitis b viral markers in the family members of asian and non-asian patients with hepatitis b surface antigen-positive hepatocellular carcinoma and with chronic hepatitis b infection. | serologic tests for evidence of hepatitis b virus (hbv) infection were performed on family members of asian and non-asian patients with either hepatitis b surface antigen (hbsag)-positive hepatocellular carcinoma or chronic hbv infection. asian family members had a significant increase of hbsag (34% higher) and of antibody to hbsag or of antibody to hepatitis b core antigen (50% higher) when they were compared with non-asian family members. in the asian group, viral markers were detected more fr ... | 1979 | 229173 |
| [retrospective study of 149 cases of hepatitis b virus infections. study of markers and of evolution]. | a retrospective study has been performed in 149 subjects with present or past hbs antigenemia. the group consisted of 8 asymptomatic carriers, 90 with acute hepatitis, 7 with fulminating hepatitis, 27 with chronic hepatitis, 16 with cirrhosis and 1 with hepatoma. the changes from one clinical condition to another, the sources of infection, the percentage of acute hepatitis in the history of chronic hepatitis cases and the working capacity an average of two years after the infection were studied. ... | 1979 | 229549 |
| [new data on the epidemiology of viral hepatitis (literature review)]. | | 1979 | 229643 |
| the relation of infection with the hepatitis b agent to primary hepatic carcinoma. | in asia, africa, and other tropical areas, primary hepatic carcinoma (phc) is associated with liver cirrhosis of the postnecrotic (macronodular) type. chronic viral hepatitis is likely to be the cause of this cirrhosis in many patients from regions where chronic infection with the hepatitis b virus (hbv) is common. more than 95% of patients with hepatoma (in mali and senegal) have evidence of infection with hbv, a much higher frequency than in controls. thirty-nine of 62 patients with phc had he ... | 1975 | 174434 |
| epstein-barr virus infection in polytransfused patients with homozygous beta-thalassaemia. | the frequency of epstein-barr virus (ebv) and hepatitis b virus (hbv) infection has been studied in 149 polytransfused thalassaemic patients and in healthy controls. evidence for ebv infection was based on the detection of antibodies to viral capsid antigen (anti-vca) and for hbv infection on the detection of either hepatitis b surface antigen (hbsag) or hepatitis b surface antibody (anti-hbs). the frequency of anti-vca was not significantly higher in the patients (16.4%) compared to the control ... | 1979 | 230639 |
| labeling of hepatitis b virus surface antigen (hbsag) synthesized in a hbsag-producing hepatoma cell line. | hepatitis b virus surface antigen (hbsag) could be studied until recently only by isolating it from the blood of carriers, thus making incorporation of radioactive precursors into this protein(s) impossible. the isolation of a cell line producing hbsag [alexander et al, 1978] has eliminated this obstacle. the cell line was therefore used for labeling hbsag either with 35s-methionine or with 35s-cystine. hbsag was purified by pelleting the component and by isopycnic centrifugation in cscl gradien ... | 1979 | 231637 |
| the effect of sodium thiocyanate on virus structure. | a study of two different virus types after elution from immunosorbent columns by sodium thiocyanate has shown that virus degradation occurs. the two virus types studied were hepatitis b and rotavirus. hepatitis b antigen (hbag) was only slowly degraded and retained many of its morphological features, although in an altered form; rotavirus was highly sensitive to the chaotropic agent, losing both its viability and its morphological integrity. during the process of disassembly a previously undetec ... | 1979 | 232143 |
| the transmission and outcome of hepatitis a, b, and non-a, non-b: a review. | | 1979 | 232876 |
| controlled synthesis of hbsag in a differentiated human liver carcinoma-derived cell line. | a significant aspect of primary hepatic carcinoma in man is the high positive correlation of hepatocellular carcinoma with infection with hepatitis b virus (hbv)1. analysis of the relationship between hbv infection and oncogenesis is difficult because natural infection with hbv is limited to man and experimental infection has been achieved only in chimpanzees and gibbons. furthermore, because hbv has not been successfully propagated in cell culture, basic study of virus-cell interaction of the a ... | 1979 | 233137 |
| [chronic hepatitis. etiopathogenesis]. | | 1979 | 233221 |
| [observations on the diffusion of hepatitis a and b virus during an epidemic in a sicilian town with a high rate of infection]. | epidemiological investigations were carried out during a viral hepatitis outbreak occurring in a sicilian town of 30,000 inhabitants with poor sanitary standards, with the aim to study the mode of spread of hav and hbv in conditions of high incidence of infections. hbsag, anti hbs, anti hav (ria), hbeag, anti hbe and anti hbc were investigated in serum samples from patients, their family contacts and from healthy individuals of different age groups. morbidity was inferred from case notifications ... | 1979 | 233297 |
| [hepatitis b virus surface antigen (hbsag) in human hepatocellular carcinoma and its surrounding tissues of liver (author's transl)]. | | 1979 | 233358 |
| [diagnosis of hepatitis by means of radioimmunoassay]. | | 1979 | 233368 |
| [pathogenic and therapeutic concepts in viral hepatitis]. | | 1976 | 175890 |
| hepatocellular carcinoma and chronic persistent hepatitis. | the morphologic type of cirrhosis that is followed most frequently by hepatocellular carcinoma is posthepatitic cirrhosis. furthermore, hb ag is detected in a high rate among cases with hepatocellular carcinoma suggesting the intimate causal relationship between hepatitis b virus and hepatocellular carcinoma. it has been considered that hepatocellular carcinoma might develop during destruction and regeneration of fully developed liver cirrhosis. however, hepatocellular carcinoma is combined with ... | 1977 | 200057 |
| letter: possible role of haematophagous insects in the transmission of type b hepatitis. | | 1975 | 241139 |
| benign and malignant liver neoplasms: some new etiologic associations. | several agents have recently been implicated in the development of benign and malignant liver neoplasms. recognition of their possible role by the primary care physician may prevent serious consequences to patients exposed to these agents, which include oral contraceptives, androgens, hepatitis virus, and vinyl chloride. | 1978 | 203904 |
| [transmission of hepatitis b virus from the mother to the infant]. | | 1977 | 243551 |
| [hepatitis b virus and prevention of its transmission]. | | 1978 | 244594 |
| [cloning of the hepatitis b virus genome in escherichia coli]. | the whole genome of the hepatitis b virus (dane particles) was inserted in vitro in the genome of the bacteriophage lambda gtwes . lambda b. the recombinant dna molecule was cloned in e. coli. amplification of the hybrid bacteriophage enables the preparation of large amounts of hepatitis b virus dna. the possibilities offered by the utilization of this recombinant bacteriophage are discussed. | 1978 | 158442 |
| viral hepatitis, type a. identification by specific complement fixation and immune adherence tests. | hepatitis a antibody was detected by specific immune adherence and complement-fixation tests in a study involving 473 serum specimens from 20 patients who had viral hepatitis, type a. in all 20 patients who had no detectable immune adherence antibody (less than 1:5) before onset of hepatitis high levels (greater than or equal to 1:1024) developed one to four weeks later, occasionally reaching peak levels exceeding greater than or equal to 1:81,920 several months thereafter. five to 10 years late ... | 1975 | 164627 |
| messenger rna hybridized with the dna isolated from hepatitis b dane particles. | | 1979 | 261965 |
| clinical and pathological findings and sequelae of viral hepatitis. | | 1975 | 169636 |
| hepatitis b prevalence within a dental student population. | in this descriptive epidemiologic study, prevalence rates of hepatitis b surface antigen (hbsag) and its antibody (anti-hbs) among fourth-year dental students and second-year dental hygiene students were found to be comparable to those of a control population and a local age-adjusted blood donor group. this observation contrasts with the rates reported for practicing dentists, especially oral surgeons, and indicates that the increased risk experienced by dentists after dental school may be attri ... | 1977 | 264921 |
| lymphocyte e rosette inhibitory factor: a regulatory serum lipoprotein. | rosette inhibitory factor, rif, previously described in serum from patients with hepatitis b virus infection, has been isolated and identified as a minor species of beta-lipoprotein of the low-density (ldl) class. it is unrelated to hepatitis b virus proteins or particles. although discrete by reference to charge and density (1.050 +/- 0.004 g/cm3), rif appears to be a complex macromolecular structure containing apolipoproteins a, b, and c. greater than 400% recovery is achieved upon 300,000-fol ... | 1975 | 172585 |
| a seroepidemiologic study of infection with hav and hbv in five pacific islands. | a batch of 1025 serum samples, obtained from healthy subjects and hospital patients from five pacific islands (viti levu, funafuti, niue, rarotonga and upolu) were tested for antibody to hepatitis a virus (anti-hav), hepatitis b surface antigen (hbsag) and antibody to hepatitis b surface antigen (anti-hbs) by solid phase radioimmunoassay (spria). high frequencies of anti-hav were observed in each population (funafuti, 79.9%; upolu, 81.6%; viti levu, 84.3%; rarotonga, 95.0%; and niue, 95.2%), and ... | 1979 | 224697 |
| host specificity of a serum marker for hepatitis b: evidence that "e antigen" has the properties of an immunoglobulin. | a family of antigens, referred to collectively as e antigen (eag), has been detected in sera of some individuals with liver disease who test positive for hepatitis b surface antigen. studies on eag partially purified by affinity chromatography on insolubilized antibodies to eag revealed the following: (i) eag has the physicochemical and immunologic properties of an immunoglobulin, predominantly of the igg4 subclass, and (ii) specific antigenic sites, designated as e determinants, differentiate e ... | 1977 | 266209 |
| association of e antigen with dane particle dna in sera from asymptomatic carriers of hepatitis b surface antigen. | sera containing hepatitis b surface antigen from 30 asymptomatic blood donors were assayed for e antigen (hbeag) and antibody to e antigen (anti-hbe) by rheophoresis,. fourteen samples (47%) had detectable hbeag, ten (33%) had anti-hbe, and six (20%) had neither. dna was extracted from 26 of these sera and assayed for its ability to anneal to a [32p]-dna probe that is a copy of dane particle dna. all 10 hbeag-positive samples tested contained dna that formed specific hybrids with the dna probe, ... | 1977 | 266736 |
| an appraisal of the relationship between primary hepatocellular carcinoma and hepatitis b virus. | the association between hepatitis b virus infection and primary hepatocellular carcinoma is reviewed. on the basis of serological and tissue examination there is a close link between virus infection and the tumour. while there is evidence to favour an oncogenic role for virus this is not conclusive, and other possible explanations for the relationship are discussed. | 1979 | 229071 |
| sex differences in response to hepatitis b infection among patients receiving chronic dialysis treatment. | patients undergoing treatment at a community-based renal dialysis clinic were monitored monthly for hepatitis b surface antigen (hbsag) and antibody to hbsag (anti-hbs). of 160 patients who began treatment hbsag(-)/anti-hbs(-), 77 subsequently became hbsag(+). once hbsag(+), males were more likely to remain hbsag(+) indefinitely, whereas females were more likely to convert to hbsag(-) and develop anti-hbs. this was not due to a sex difference in exposure to hepatitis b virus because only patient ... | 1977 | 267950 |
| an inquiry into the sterilization of dental handpieces relative to transmission of hepatitis b virus. | the transmission of the hepatitis b virus has been implicated in the dental office. the dental profession should be keenly aware of aseptic clinical techniques and effective sterilization procedures. some dental handpieces can be damaged by conventional sterilization procedures. alternative procedures are discussed. a review of currently available handpieces and their appropriate sterilization procedures is presented. | 1978 | 273633 |
| the virus of hepatitis b a new dimension in the diagnosis of sexually transmitted disease. | ten patients presenting with venereal or dermatological disorders have been found to have evidence of infection with the virus of hepatitis b; only five had distinguishable liver dysfunction, yet all had either detectable antigen or antibody. antigen subtype ayw has been identified in four of these people. once rare in the local population, hepatitis b virus infection appears to be increasing in incidence with cases attributable to inoculation and to direct contact, as well as presenting as a co ... | 1978 | 273792 |
| duality of hepatitis b e antigen in serum of persons infected with hepatitis b virus: evidence for the nonidentity of e antigen with immunoglobulins. | hepatitis b e antigen (hbeag) is detected in the serum of some persons infected with hepatitis b virus. owing to a close correlation of hbeag and hepatitis b virus in the serum, it has been used as a practical indicator of infectivity. two entities of hbeag activity physicochemically different from each other were demonstrated in the serum of persons infected with hepatitis b virus. one was associated with a molecule that precipitated in 1.33 m ammonium sulfate solution, was larger than igg, and ... | 1978 | 273922 |
| studies of donors who transmit posttransfusion hepatitis. | sera and questionnaires were evaluated retrospectively from 128 volunteer blood donors whose blood had been implicated in cases of clinically recognized post-transfusion hepatitis in recipients of one- or two-unit blood transfusion between 1971 and 1977. serologic markers of hepatitis b virus (hbv) infection were found in 23 percent, compared to 9.7 percent of 3,230 prospective blood donors. the prevalence of antibody to hepatitis a virus was similar among implicated donors (44%), prospective do ... | 1979 | 230620 |
| studies on the subtypes of hepatitis b surface antigen-demonstration of vertical and intrafamilial transmission of hepatitis b virus. | | 1978 | 275454 |
| [physiopathology of hepatitis b virus infection]. | hepatitis b associated antigen (hb-ag) may be observed in the serum in subjects either apparently healthy or exhibiting a number of disease symptoms. its incidence among the geneva voluntary blood donors is 0.48% with 54% exhibiting the surface antigen ad and 34% ay. while the hb-ag positive blood donors appeared clinically healthy, minor pathology was found in the majority of them (thrombocytopenia, histological evidence of inflammatory foci, of persistent hepatitis and of chronic aggressive he ... | 1975 | 240199 |
| past infection with hepatitis b virus in patients at a dental school. | samples of blood from 327 new patients at a dental school were tested by radioimmunoassay for the presence of hepatitis b surface antigen (hbsag) and hepatitis b surface antibody (anti-hbs). the data were compared to the patients' histories of hepatitis. through a statistical analysis, it was indicated that significant numbers of patients with no history of hepatitis had been infected with hepatitis b virus. | 1978 | 279604 |
| a seroepidemiologic study of hepatitis b virus infection in taiwan. | | 1978 | 284101 |
| hepatitis b (surface) antigen in mothers and their infants. | hepatitis b (surface) antigen (hbsag) was found in the serum of 8 out of 4 245 women attending the antenatal clinic of the queen victoria maternity hospital seven (0, 16%) were asymptomatic carriers of the antigen, while the eigth suffered from polyarteritis nodosa. seven of the 8 babies born to these mothers were followed-up over periods of up to 18 months, and 1 has become a chronic carrier of hbsag. the antigen was not detected in the colostrum (breast milk) of the 6 positive mothers tested, ... | 1975 | 240207 |
| hepatitis b virus infection in dental students. a two-year evaluation. | | 1979 | 289728 |
| hepatitis b and the dental health professional--an updating. | | 1978 | 289876 |
| hepatitis ain greenland: importance of specific antibody testing in epidemiologic surveillance. | an epidemic of viral hepatitis type a in an arctic area is described. from 1970-1974, 4961 clinical cases of hepatitis were reported in greenland, corresponding to 11 per cent of the total population. epidemiologic surveillance indicated person-to-person transmission of the disease, apparently by the oralfecal route. the course of the disease was mild, and complications were rare with a case fatality rate of 0.3%. ninety-three per cent of the cases occurred in individuals 1-25 years of age, sugg ... | 1977 | 189600 |
| [hepatitis b virus and clinical dentistry]. | | 1978 | 295032 |
| recent advances in the identification of hepatitis viruses. | resulting directly from the discovery of virus-related antigens, rapid progress has marked the last decade of viral hepatitis research. the hepatitis b virion has been tentatively identified as a dna virus with an endogenous dna polymerase, and new serological markers for type b hepatitis have been discovered. hepatitis a antigen has been identified on a virus-like particle thought to be the hepatitis a virion. progressively more sophisticated assays for hepatitis antigens and antibodies have be ... | 1977 | 196274 |
| extrahepatic manifestations of viral hepatitis. | recent evidence indicates that viral hepatitis is sometimes associated with the production of extrahepatic tissue injury. hepatitis b virus (hbv) infection is most commonly incriminated but non-type b hepatitis may also be involved. three types of syndromes have been recognized. first, a serum sickness-like prodrome consisting of skin eruptions, urticaria and polyarthralgias or arthritis may occur from one to six weeks prior to the onset of hepatitis in 15 to 20 per cent of patients and usually ... | 1975 | 242219 |
| serologic markers of hepatitis a and b in chronic active hepatitis. | sera from 44 patients with a well-documented diagnosis of chronic active hepatitis (cah) were analysed for antibodies to hepatitis a virus (anti-hav), hepatitis b surface antigen (hbsag) and anti-hbs, e-antigen (hbeag) and anti-hbe, as well as antibodies to hepatitis b core antigen (anti-hbc). twenty-two patients had serologic evidence of hepatitis a infection. the frequency of anti-hav was low in patients under 50 years of age (21%) but high among older patients (72%). there was, however, no si ... | 1978 | 212821 |
| peripheral blood and liver tissue t and b lymphocytes and hepatitis b virus (hbv) | | 1978 | 303581 |
| hepatitis b virus infection and chronic liver disease in taiwan. | three hundred and eighty-five patients mostly with chronic liver diseases and 729 apparently healthy adults were studied for hepatitis b surface antigen (hbsag) with reversed passive hemagglutination and antibody (anti-hbs) with passive hemagglutination. in healthy adults around 15% was hbsag positive and in 45% was anti-hbs positive, estimating hepatitis b virus (hbv) infection in nearly two thirds of the population. the infection already occurred before adulthood. the prevalences of hbsag were ... | 1978 | 214987 |
| hepatocellular carcinoma in the u.s.a., etiologic considerations. localization of hepatitis b antigens. | the serologic and tissue markers of hepatitis b virus (hbv) were studied in 50 patients in whom hepatocellular carcinoma (hcc) was confirmed at autopsy. serologic and tissue markers included serum hepatitis b surface antigen (hbsag), tissue hbsag, tissue hepatitis core antigen (hbcag), and serum antibody to hbcag (anti-hbc). twenty-two patients had hcc arising in alcoholic cirrhosis; 2 of the 22 (9.1%) had one or more of the hbv tissue and serologic markers. this infection rate is similar to the ... | 1979 | 215488 |
| [gianotti disease and hepatitis b virus (author's transl)]. | | 1978 | 310483 |
| fibroblast interferon treatment of a patient with chronic active hepatitis. increased number of circulating t lymphocytes and elimination of rosette-inhibitory factor. | a 23 year old woman with chronic active hepatitis documented by liver biopsy demonstrated persistent hepatitis b surface antigen, hepatitis b virus specific dna polymerase hepatitis b core antigen (hbcag), for approximately one year. the number of circulating t lymphocytes that rosetted with sheep erythrocytes was decreased, and a rosette-inhibitory factor was present in her peripheral blood. interferon treatment (1 x 10(6) u/day intramuscularly for 82 days) resulted in a decrease of hbsag and d ... | 1979 | 313705 |
| antibodies to single stranded dna: a diagnostic aid in chronic hepatitis b virus infections. | serial determinations of titers of binding antibodies to single stranded dna were performed over a period of three years in 43 type b hepatitis patients with persisting hbsag who had either developed chronic hepatitis or were asymptomatic carriers. patients with histopathological diagnosis of chronic active or chronic persistent hepatitis, with or without clinical symptoms, showed high titers of anti-dna throughout the course of the disease, whereas in most of these patients the serum alanine tr ... | 1979 | 314970 |
| hepatic infections. part ii. the effect of acute and chronic hepatitis b antigenaemia on the reaction to antibodies to sheep red cells (microbial antigens) and human t-activated cells (exposed autologous tissue antigens). | using the agglutination of sheep red cells by human antibodies as an indicator of microbial antibody activity, a highly significant association was found between the response to the e antigen of the hepatitis b virus and the formation of strong antibody levels to microbial substances (chi 2(1) = 33). this kind of association was not found among chronic carriers of the hepatitis b virus who do not produce antibodies to the e antigen (chi 2(1) = 3,7). in the presence of e antigen activity, patient ... | 1979 | 315618 |
| the pathogenesis of hepatitis b: possible mechanisms of viral replication and tissue injury. | | 1980 | 317875 |
| association of graft survival with host response to hepatitis b infection in patients with kidney transplants. | we studied the relation of host response to hepatitis b infection before transplantation with survival of kidney grafts in 79 patients receiving 87 transplants. antibody to hepatitis b surface antigen (anti-hbs) signaled early graft rejection (median survival congruent to two months), whereas hepatitis b surface antigen (hbsag) signaled delayed rejection (greater than 22 months). patients with neither hbsag nor anti-hbs had graft survival times (median congruent to 16 months) similar to the hbsa ... | 1977 | 318732 |
| acute and chronic hepatitis: multisystemic involvement related to immunologic disease. | | 1977 | 320847 |
| [epidemiological study of hepatitis b virus in children in the aki area, kochi-ken, japan]. | | 1977 | 321837 |
| identification of lymphocytes in percutaneous liver biopsy cores. different t:b cell ratio in hb sag-positive and -negative hepatitis. | the lymphocytes infiltrating the liver were isolated and characterized as t or b cells in three groups of patients: 20 patients with hepatitis b surface antigen (hb sag)-positive acute and chronic hepatitis, 8 patients with hbsag-negative chronic hepatitis with prior evidence for hepatitis b virus (hbv) infection, and 5 patients with hbsag-negative chronic hepatitis without prior evidence for hbv infection. the predominant cell infiltrating the liver was shown to be a t cell in all categories; h ... | 1977 | 323096 |
| [medical nobel prize in 1976]. | | 1977 | 323771 |
| vertical transmission of hepatitis-b surface antigen. | transmission of hepatitis b virus from mother to infant can cause a severe type of neonatal hepatitis. comparing chronic carrier mothers with mothers who have acute hepatitis in pregnancy we find that the latter group present the greater risk to their infants. differences in the presence of hepatitis b core and hepatitis b e antigen and antibody in the acute case and in the carrier state may expoain the differences observed in the transmission rates of two groups. in countries where the prevalen ... | 1977 | 324529 |
| antibodies to hepatitis b core antigen in hepatitis b surface antigen-positive and -negative chronic hepatitis. | antibody to hepatitis b core antigen (anti-hbc) is a sensitive indicator of hepatitis b virus (hbv) infection. however, anti-hbc has been found in only a few patients with chronic hepatitis. therefore, we tested for anti-hbc in 124 sera from 67 patients with histologically proven chronic hepatitis by the indirect fluorescent antibody technique. all patients, except for one with chronic hepatitis who was seropositive for hepatitis b surface antigen (hbs ag), had anti-hbc that persisted throughout ... | 1977 | 325149 |
| australia antigen and the biology of hepatitis b. | | 1977 | 325649 |
| hepatitis, an occupational hazard. | | 1977 | 217861 |
| [magnius' e-antigen]. | the "e" ag/ac system found by magnius in 1972 is discussed briefly. the new antigen has the same immologic and physiochemical characteristics of hbs and hbc of the hepatitis virus. its existence shows the chronic evolution of the disease in ag hbs carriers. therefore the "e" antigen has a prognostic value in ag hbs carries. | 1977 | 329074 |
| comparative immunology of hepatitis a and b. | | 1979 | 218418 |
| eukaryotic dna polymerases. | | 1977 | 332062 |
| viral type a and type b hepatitis: morphology, biology, immunology and epidemiology--a review. | viral hepatitis is one of the most serious infectious diseases in the united states and is of great concern to the public health agencies, hospitals and research laboratories. progress in our knowledge of this disease has been based on cooperation between specialists in many diverse scientific disciplines employing sophisticated scientific instruments and technics. close cooperation between clinical pathologists and clinicians is of great importance in diagnosis. biologic, immunologic, epidemiol ... | 1976 | 218439 |
| simultaneous presence of hbsag and anti-hbs in the serum of different subtypes (serological and immunofluorescent studies). | serological and immunofluorescent studies were performed in 3 patients with the simultaneous presence of hbsag and anti-hbs in the serum. our investigations revealed the following results: hbsag and anti-hbs in the serum were of different subtypes. hbsag in the serum and in the liver had the same subtype. hbsag in the liver did not react with the circulating anti-hbs in the patient's own serum. hbsag-anti-hbs immune complexes could not be detected in the serum or in the liver tissue. these pheno ... | 1977 | 333803 |
| hepatitis b in ward and clinical laboratory employees of a general hospital. | after a sharp increase in viral hepatitis cases, mostly type b, among the 2000 employees of a general hospital during three years, we conducted an investigation which consisted of obtaining data on employee cases and surveying many current employees. of the 38 cases, 22 occurred in non-physician, ward employees. of 189 current ward employees, 8% had antibody to hepatitis b surface antigen (anti-hbs) and 1% had hepatitis b surface antigen (hbsag). hepatitis b virus (hbv) seropositivity was highes ... | 1977 | 333905 |
| the genome of hepatitis b virus. | | 1977 | 334041 |
| cytoplasmic hepatitis b surface antigen and the ground-glass appearance in hepatocellular carcinoma. | hepatitis b surface antigen (hbsag) was identified with aldehyde fuchsin and immunoperoxidase stain and by immunofluorescence in malignant hepatocytes with a ground-glass appearance in only one needle biopsy specimen of a series of biopsies from 130 consecutive cases of hepatocellular carcinoma. the patient was 14 years old. hbsag was identified by aldehyde fuchsin stain in nonmalignant hepatocytes of 48 (58%) of 83 biopsy specimens that contained nonmalignant liver tissue. the antigen was demon ... | 1979 | 218445 |
| hepatitis b virus antigens in primary hepatic carcinoma: immunofluorescent techniques on fixed liver tissue. | the presence of hepatitis b surface (hbsag) and core (hbcag) antigens was investigated by immunofluorescence in specimens of liver tissue obtained at necrospy in 107 patients with primary hepatic carcinoma. hbsag was detected in the cytoplasm of liver cells in 16 cases, and in eight of them the antigen was also found in malignant cells. hbcag, which was present in the nuclei of liver cells in eight cases, was detected in the nuclei of tumour cells in six of these and also in two other cases show ... | 1978 | 219038 |
| [hepato-cellular carcinoma associated with hbs antigen: a study of 25 cases from vietnam (author's transl)]. | using orcein staining and indirect immunofluorescence on paraffin sections, the authors demonstrated hbs ag in 64% of 25 hepatocellular carcinomas (including "bone metastasis") in vietnam. the main findings in the literature suggesting a causal role for hepatitis b virus in primary liver cancer are discussed. | 1978 | 219448 |
| hepatitis viruses. | | 1978 | 340799 |
| viral hepatitis. | | 1975 | 169519 |
| role of hepatitis b virus in primary liver cancer. | there is an excess prevalence of markers of active infection with hepatitis b virus in patients with primary liver cancer in many parts of the world. early age of infection with hepatitis b virus is likely to be an important factor, resulting in persistent infection that may progress to chronic liver damage. results of recent experimental studies are consistent with integration of hepatitis b viral dna with host cell dna molecules. it is likely that primary liver cancer is the cumulative result ... | 1979 | 224199 |
| prevalence of antibody to hepatitis a and hepatitis b viruses in selected populations of the south pacific. | five island populations representing the three major cultural groups of the south pacific--polynesia, micronesia, melanesia--were studied for prevalence of antibody to hepatitis a virus (anti-hav) and of antibody to the core antigen of hepatitis b virus (anti-hbc). sera were collected in the late 1950s and early 1960s, selected where possible for appropriate age and sex distributions, and were tested by radioimmunoassay. rather marked differences in prevalence were observed. anti-hbc patterns co ... | 1979 | 224696 |
| [prevention and therapy of viral hepatitis]. | | 1979 | 253774 |
| [prognosis of viral hepatitis]. | | 1979 | 253775 |
| prevalence of antibody to hepatitits b surface antigen among staff in an edinburgh hospital. | antibody to hepatitis b surface antigen was detected by radioimmunoprecipitation in 74 (5-5%) of 1336 staff members in a large general hospital in edinburgh, in 14 (2-9%) of 480 volunteer blood donors in the area, and in 12 (6-1%) of 197 pregnant women attending for the first time at the ante-natal clinic in the hospital. rates of antibody prevalence rose with age in the sample of hospital staff and in that of the blood donors, particularly among males. on the other hand, in the ante-natal patie ... | 1977 | 264499 |
| [the dentist's responsibility in the oral rehabilitation of patients with chronic kidney diseases]. | it is important that the dentist knows about disturbances of blood coagulation during and after hemo-dialysis, so that he avoids administration of platelet-inhibiting medication like aspirin and that he recognizes radiologically visible signs of insufficient dialysis in the jaws. because of the reduced protection from infections, antibiotic prophylaxis should be carried out before every dental operation, the medication of choice being penicillin. due to the high rate of infection by the hepatiti ... | 1977 | 265241 |
| partial amino acid sequence of two major component polypeptides of hepatitis b surface antigen. | determination of the amino acid sequence of the immunogenic polypeptides of hepatitis b surface antigen may not only permit molecular localization of the distinct determinants a, d, and y but may also lead to the synthesis of a hapten useful in prophylactic immunization against hepatitis b virus infection. for this purpose, purified monotypic hepatitis b surface antigen of adw subtype was resolved into equal amounts of two major polypeptides (22,000 and 28,000 daltons) and up to six other minor ... | 1977 | 266193 |
| rebuttal to a jama editorial: hepatitis b--traffic in the dentist's office. | | 1977 | 267655 |
| immunological abnormalities associated with liver disease: cause or effect? | immunological abnormalities are demonstrable in patients with various types of liver damage. these may be (a) non-specific and unrelated to pathogenesis, e.g. auto-antibodies such as anti-nuclear factor; (b) specifically directed against liver antigens but not pathogenetic, e.g. cell mediated immune (cmi) reactions to liver antigen as seen in experimental carbon tetrachloride poisoning; (c) of such a nature as to modify the pathology produced by hepatotoxic agents, e.g. hepatitis b virus or alco ... | 1977 | 274938 |
| the dental practitioner and systemic infections of oral origin. | | 1978 | 279514 |
| serum iron levels and response to hepatitis b virus. | response to hepatitis b virus (hbv) infection [hbv surface antigen (hbsag) and antibody to hbsag (anti-hbs)], serum iron, total iron-binding capacity, hematological status (erythrocytes, hb, and hematocrit), and evidence of liver damage (serum glutamic pyruvic transaminase; aspartate aminotransferase, l-aspartate:2-oxoglutarate aminotransferase, ec 2.6.1.1) were determined for 201 patients on chronic renal dialysis. four factors-serum iron level, transminase level, sex, and hbv response [i.e., i ... | 1979 | 287082 |
| restriction endonuclease cleavage map and location of unique features of the dna of hepatitis b virus, subtype adw2. | dna of hepatitis b virus (hbv) of hepatitis b surface antigen (hbsag) subtype adw2 made fully double stranded by the virion dna polymerase and radiolabeled either by the virion dna polymerase reaction or by nick-translation with 32p-labeled deoxynucleoside triphosphates was used to establish a map of restriction endonuclease cleavage sites by the method double and triple enzyme digestion and to determine the relative positions of several unique physical features of this dna. the five restriction ... | 1979 | 291995 |