PMID(sorted descending)
environmental factors influencing multiple sclerosis in latin is generally accepted that autoimmune diseases like multiple sclerosis (ms) arise from complex interactions between genetic susceptibility and environmental factors. genetic variants confer predisposition to develop ms, but cannot be therapeutically modified. on the other hand, several studies have shown that different lifestyle and environmental factors influence disease development, as well as activity levels and progression. unlike genetic risk factors, these can be modified, with potentia ...201728638627
genome-wide analysis of 18 epstein-barr viruses isolated from primary nasopharyngeal carcinoma biopsy specimens.epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus that is highly prevalent in almost all human populations and is associated with many human cancers, such as nasopharyngeal carcinoma (npc), hodgkin's disease, and gastric carcinoma. however, in these ebv-associated cancers, only npc exhibits remarkable ethnic and geographic distribution. we hypothesized that ebv genomic variations might contribute to the pathogenesis of different human cancers in different geographic areas. in this study, ...201728637758
arsenic trioxide inhibits ebv reactivation and promotes cell death in ebv-positive lymphoma cells.epstein-barr virus (ebv) is associated with hematopoietic malignancies, such as burkitt's lymphoma, post-transplantation lymphoproliferative disorder, and diffuse large b-cell lymphoma. the current approach for ebv-associated lymphoma involves chemotherapy to eradicate cancer cells, however, normal cells may be injured and organ dysfunction may occur with currently employed regimens. this research is focused on employing arsenic trioxide (ato) as ebv-specific cancer therapy takes advantage of th ...201728637474
[morphological diagnosis of viral damage to a kidney transplant].due to the development of organ transplantation and its accompanying immunosuppression, recent years have been marked by the higher incidence of opportunistic viral infections that are of considerable importance among posttransplantation complications. a variety of viral infections, the possibility of their concomitant or subtle course, and the ability to cause life-threatening complications in recipients make relevant the description of existing diagnostic methods. the article summarizes the da ...201628635942
effects of type 1 diabetes risk alleles on immune cell gene expression.genetic studies have identified 61 variants associated with the risk of developing type 1 diabetes (t1d). the functions of most of the non-hla (human leukocyte antigen) genetic variants remain unknown. we found that only 16 of these risk variants could potentially be linked to a protein-coding change. therefore, we investigated whether these variants affected susceptibility by regulating changes in gene expression. to do so, we examined whole transcriptome profiles of 600 samples from the type 1 ...201728635624
mumps clinical diagnostic uncertainty.during recent years, various mumps outbreaks have occurred among populations vaccinated for mumps worldwide. in italy, improving routine coverage with two doses of measles, mumps and rubella (mmr) vaccine is one of the key strategies to eliminate measles and rubella. to monitor the effect of the vaccination programme on the population, the surveillance of these vaccine-preventable diseases has been implemented. this provided the opportunity to evaluate the accuracy of the clinical diagnosis of t ...201728633302
[braf-positive paucicellular variant of anaplastic carcinoma in the presence of tall cell variant papillary thyroid cancer].to paper describes a case of paucicellular anaplastic cancer in the presence of tall cell variant papillary thyroid carcinoma. microscopic examination showed that the differentiated component of the tumor was composed of papillary structures with tall cells, the height of which exceeded 3-4 times the width. its anaplastic component consisted of fibrous tissue with occasional spindle-shaped cells and focal lymphocytic infiltration to the extent of 70%. the spindle-shaped cells expressed cytokerat ...201728631713
anti-herpes simplex virus type 1 activity of houttuynoid a, a flavonoid from houttuynia cordata thunb.early events in herpes simplex virus type 1 (hsv-1) infection reactivate latent human immunodeficiency virus, epstein-barr virus, and human papillomavirus in the presence of acyclovir (acv). the common use of nucleoside analog medications, such as acv and pencyclovir, has resulted in the emergence of drug-resistant hsv-1 strains in clinical therapy. therefore, new antiherpetics that can inhibit early events in hsv-1 infection should be developed. an example of this treatment is houttuynia cordat ...201728629987
immunotherapy for transplantation-associated viral infections.cytomegalovirus (cmv) and epstein-barr virus (ebv) infections following allogeneic hematopoietic stem cell transplantation (hsct) are a major cause of morbidity and mortality. early clinical trials demonstrate that adoptive transfer of donor-derived virus-specific t cells to restore virus-specific immunity is an effective strategy to control cmv and ebv infection after hsct, conferring protection in 70%-90% of patients. the field has evolved rapidly to develop solutions to some of the manufactur ...201728628043
[evaluation of dynamic telomere length shortening of lymphocytes in immunocompromised children with chronic diseases of the respiratory].nowadays it is common to observe the growth of viral-viral and viral-bacterial co-infections in children of different ages, due to dysfunction of lymphocytes (dl), which can be connected with the process of the accelerated shortening of the end structures of chromosomal telomeres, telomere length changes are described in lymphocytes of children with chronic mono-infections. the conducted study has shown the shortening of telomere lymphocytes in children with cdrt seropositive for mixed-herpes vi ...201728628024
a rare case of three distinct epstein-barr virus associated lymphoproliferative disorders over sixteen years of human immunodeficiency virus infection.epstein barr virus (ebv) is well known to cause different types of malignancies. in immunocompromised patients, such as those infected with human immunodeficiency virus (hiv), there is a higher likelihood of ebv related malignant transformation. diagnosis of ebv related malignancies may be difficult and sometimes requires clinical and pathological correlation. it is very rare to have more than one type of ebv related malignancy in a single patient. until now, there are no specific guidelines for ...201728626541
phenotypic and functional characterization of t cells in white matter lesions of multiple sclerosis patients.t cells are considered pivotal in the pathology of multiple sclerosis (ms), but their function and antigen specificity are unknown. to unravel the role of t cells in ms pathology, we performed a comprehensive analysis on t cells recovered from paired blood, cerebrospinal fluid (csf), normal-appearing white matter (nawm) and white matter lesions (wml) from 27 ms patients with advanced disease shortly after death. the differentiation status of t cells in these compartments was determined by ex viv ...201728624961
seasonality and autoimmune diseases: the contribution of the four seasons to the mosaic of autoimmunity.autoimmune diseases (ads) are a heterogeneous groups of diseases that occur as a results of loss of tolerance to self antigens. while the etiopathogeneis remain obscure, different environmental factors were suggested to have a role in the development of autoimmunity, including infections, low vitamin d levels, uv radiation, and melatonin. interestingly, such factors possess seasonal variation patterns that could influence disease development, severity and progression. vitamin d levels which reac ...201728624334
aggressive natural killer cell leukemia or extranodal nk/t cell lymphoma? a case with nasal involvement.aggressive natural killer cell leukemia/lymphoma (ankl) is a rare and highly aggressive nk cell neoplasm with a short clinical course and poor prognosis and is often misdiagnosed and confused with nk/t cell lymphoma (nktl), which has a very different prognosis. here, we present a case with nasal and bone marrow involvement, provide a literature review and make a differential diagnosis.201728623913
primary progressive multiple sclerosis: putting together the puzzle.the focus of multiple sclerosis research has recently turned to the relatively rare and clearly more challenging condition of primary progressive multiple sclerosis (ppms). many risk factors such as genetic susceptibility, age, and epstein-barr virus (ebv) infection may interdepend on various levels, causing a complex pathophysiological cascade. variable pathological mechanisms drive disease progression, including inflammation-associated axonal loss, continuous activation of central nervous syst ...201728620346
vitamin d and multiple sclerosis: an update.the most recent findings linking exposure to sun and vitamin d insufficiency to multiple sclerosis (ms) are reviewed. due to insufficient sunshine and changing lifestyles, hypovitaminosis d is widespread in temperate countries. numerous epidemiological studies have strongly suggested that sunshine and vitamin d insufficiency contributes to ms risk in these countries. moreover, several large genetic studies in ms patients have recently stated unequivocally that diverse abnormalities involving vit ...201728619429
hypoxia-inducible factor-1α plays roles in epstein-barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early bzlf1 gene promoter.when confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (hif-αs). we report here that hif-1α also regulates the life cycle of epstein-barr virus (ebv). incubation of ebv-positive gastric carcinoma ags-akata and snu-719 and burkitt lymphoma sal and kemiii cell lines with a prolyl hydroxylase inhibitor, l-mimosine or deferoxamine, or the neddylation inhibitor mln49 ...201728617871
looking into enteric virome in patients with ibd: defining guilty or innocence?although there is some evidence suggesting that certain viruses may be involved in the onset of inflammatory bowel disease (ibd), data regarding viral prevalence and viral load in blood and mucosa of patients with ibd are scarce. the main aim of this study is to evaluate the prevalence and viral load of common epstein-barr virus (ebv), cytomegalovirus (cmv), and human herpes virus 6 in blood and mucosa of adult patients with endoscopic active ibd.201728617757
epstein-barr virus-induced gene 2 and leukocyte airway recruitment in response to allergen challenge. 201728617082
diagnostic algorithm for relapsing acquired demyelinating syndromes in establish whether children with relapsing acquired demyelinating syndromes (rds) and myelin oligodendrocyte glycoprotein antibodies (mog-ab) show distinctive clinical and radiologic features and to generate a diagnostic algorithm for the main rds for clinical use.201728615429
primary central nervous system t-cell lymphoma with aberrant expression of cd20 and cd79a: a diagnostic pitfall.primary central nervous system t-cell lymphoma (pcnstcl) is rare, accounting for 2% of cns lymphomas. we report the first case of pcnstcl with aberrant expression of cd20 and cd79a in an 81-year-old man with a left periventricular brain mass. a biopsy revealed dense lymphoid infiltrate consisting of medium-sized cells in a background of gliosis and many histiocytes. the lymphoid cells were positive for cd2, cd3, cd7, cd8, t-cell intracellular antigen-1, granzyme b, cd20, and cd79a and negative f ...201728612664
genetics and molecular biology of epstein-barr virus-encoded bart microrna: a paradigm for viral modulation of host immune response genes and genome stability.epstein-barr virus, a ubiquitous human herpesvirus, is associated through epidemiologic evidence with common autoimmune syndromes and cancers. however, specific genetic mechanisms of pathogenesis have been difficult to identify. in this review, the author summarizes evidence that recently discovered noncoding rnas termed microrna encoded by epstein-barr virus barf (bamhi a right frame) termed bart (bamhi a right transcripts) are modulators of human immune response genes and genome stability in i ...201728612032
malignant salivary gland tumors and epstein-barr virus (ebv) infection: a systematic review and meta-analysisbackground: salivary gland tumors are rare head and neck tumors with lymphoepithelial carcinoma (lec) as a particularly infrequent variant. this study was an evaluation of the incidence of ebv infection in malignant salivary gland tumors with the emphasis on tumor type and geographical area. methods: five databases (pubmed, sciencedirect, scopus, web of science and cochrane library) were searched for data on the prevalence of ebv in malignant salivary gland tumors. a random-effects meta-analysis ...201728610402
lymphoproliferative disorders of the lung.this review aims to describe some of the most frequent lymphoproliferative disorders arising from the lung: pulmonary mucosa-associated lymphoid tissue (malt) lymphoma, lymphomatoid granulomatosis (lg), multicentric castleman disease (mcd), primary effusion lymphoma (pel), and nodular lymphoid hyperplasia (nlh). primary pulmonary lymphoma is defined as a clonal lymphoproliferative disorder affecting one or both lungs, without extrapulmonary involvement 3 months after diagnosis, and includes pulm ...201728609772
an essential role of virus-infected b cells in the marmoset experimental autoimmune encephalomyelitis model.infection with epstein-barr virus (ebv) has been associated with an enhanced risk of genetically susceptible individuals to develop multiple sclerosis (ms). however, an explanation for the contrast between the high ebv infection prevalence (60-90%) and the low ms prevalence (0.1%) eludes us. here we propose a new concept for the ebv-ms association developed in the experimental autoimmune encephalomyelitis model in marmoset monkeys, which are naturally infected with the ebv-related γ1-herpesvirus ...201728607749
epstein-barr virus-induced up-regulation of tcab1 is involved in the dna damage response in nasopharyngeal carcinoma.telomerase cajal body protein 1 (tcab1), which is involved in cajal body maintenance, telomere elongation and ribonucleoprotein biogenesis, has been linked to cancer predisposition, including nasopharyngeal carcinoma (npc), due to its oncogenic properties. however, there are no specific reports to date on the functional relevance of tcab1 and epstein-barr virus (ebv), which is considered to be a risk factor for npc. in this study, we first examined npc clinical tissues and found a notable overex ...201728607398
serological profiling of the ebv immune response in chronic fatigue syndrome using a peptide microarray.epstein-barr-virus (ebv) plays an important role as trigger or cofactor for various autoimmune diseases. in a subset of patients with chronic fatigue syndrome (cfs) disease starts with infectious mononucleosis as late primary ebv-infection, whereby altered levels of ebv-specific antibodies can be observed in another subset of patients.201728604802
limited nucleotide pools restrict epstein-barr virus-mediated b-cell immortalization.activation of cellular oncogenes as well as infection with tumor viruses can promote aberrant proliferation and activation of the host dna damage response. epstein-barr virus (ebv) infection of primary human b cells induces a transient period of hyper-proliferation, but many of these infected cells succumb to an ataxia telangiectasia mutated/checkpoint kinase 2 (atm/chk2)-mediated senescence-like growth arrest. in this study, we assessed the role of dna replicative stress and nucleotide pool lev ...201728604764
prognostic value of serum epstein-barr virus antibodies in patients with nasopharyngeal carcinoma and undetectable pretreatment epstein-barr virus dna.epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma (npc). serum iga antibodies against early antigen (ea-iga) and viral capsid antigen (vca-iga) are the most commonly used to screen for npc in endemic areas. however, the prognostic value of serum ea-iga and vca-iga in patients with npc is less clear. we hypothesize that serum ea-iga and vca-iga levels have prognostic impact for survival outcomes in npc patients with undetectable pretreatment ebv (pebv) dna. in this seri ...201728603915
impact of stem cell graft on early viral infections and immune reconstitution after allogeneic transplantation in adults.viral infections are well-known complications after allogeneic stem cell transplant (allo-sct).201728601677
ebv infection and msi status significantly influence the clinical outcomes of gastric cancer patients.epstein-barr virus (ebv) and microsatellite instability (msi) are associated with the carcinogenesis of many kinds of tumors, including gastric cancer (gc). however, the impact of ebv and msi status on the prognosis of stage ii and iii gc is still unclear. the aim of this study was to find out the prognostic value of ebv and msi status in a population of gc patients from southern china.201728601671
rare case of epstein-barr virus-associated early gastric cancer with multiple synchronous intramucosal lesions. 201728597982
epstein-barr virus-associated lymphoproliferative disorders: review and update on 2016 who classification.epstein-barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. most people are asymptomatic and live their entire lives in a chronically infected state (igg positive). however, in some populations, the epstein-barr virus (ebv) has been involved in the occurrence of a wide range of b-cell lymphoproliferative disorders (lpds), including burkitt lymphoma, classic hodgkin's lymphoma, and immune-deficiency associated lpds (post-transplant ...201728592786
micrornas of epstein-barr virus control innate and adaptive antiviral immunity.epstein-barr virus (ebv) has established lifelong infection in more than 90% of humanity. while infection is usually controlled by the immune system, the human host fails to completely eliminate the pathogen. several herpesviral proteins are known to act as immunoevasins, preventing or reducing recognition of ebv-infected cells. only recently were micrornas of ebv identified to reduce immune recognition further. this gem summarizes what we know about immunomodulatory micrornas of herpesviruses.201728592533
are the polyomaviruses bk and jc associated with opportunistic infections, graft-versus-host disease, or worse outcomes in adult patients receiving their first allogeneic stem cell transplantation with low-dose alemtuzumab?the association of polyomaviruses bk and jc with other opportunistic infections and graft-versus-host disease (gvhd) in allogeneic stem cell transplantation is controversially discussed.201728591758
a case report of lymphoid intestitial pneumonia in common variable immunodeficiency: oligoclonal expansion of effector lymphocytes with preferential cytomegalovirus-specific immune response and lymphoproliferative disease promotion.lymphoid interstitial pneumonia (lip) is a rare disease with lymphocytic infiltration of the alveolar interstitial and air spaces, sometimes classified as a clonal lymphoproliferative disease (lpd) with high prevalence in patients with immunodysregulation. although association of mucosa-associated lymphoid tissue (malt) lymphoma development with infectious agents has been well described, it is not so in the case of lip. attempts to demonstrate an infective cause by direct microbe detection have ...201728591035
epstein-barr virus-positive mucocutaneous ulcer mimicking rectal carcinoma at 18f-fdg pet/ct.we report focally intense f-fdg pet/ct rectal activity (suvmax = 25) with a horseshoe distribution in an 81-year-old man with b-cell chronic lymphocytic leukemia and suspected richter transformation. while imaging findings were typical for rectal adenocarcinoma, histology revealed epstein-barr virus-positive mucocutaneous ulcer.201728590301
aberrant expression of aid and aid activators of nf-κb and pax5 is irrelevant to ebv-associated gastric cancers, but is associated with carcinogenesis in certain ebv-non-associated gastric cancers.epstein-barr virus-associated gastric carcinoma (ebvagc) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma-like histology. aberrant expression of activation-induced cytidine deaminase (aid) as a genomic modulator was demonstrated through pathogen-related nuclear factor κb (nf-κb) signaling in helicobacter pylori-associated gastric cancer. to elucidate whether or not aid expression is relevant to carcinogenesis in ebvagc, immunohisto ...201728588701
bromodomain and extraterminal inhibitors block the epstein-barr virus lytic cycle at two distinct steps.lytic infection by the epstein-barr virus (ebv) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. proteins in the bromodomain and extraterminal (bet) family regulate multiple stages of viral life cycles and provide promising intervention targets. synthetic small molecules can bind to the bromodomains and disrupt function by preventing recognition of acetylated lysine substrates. we demonstrate that jq1 and other bet inhibitors block two different ste ...201728588024
clinical significance of p53 protein expression, beta-catenin expression and her2 expression for epstein-barr virus-associated gastric cancer.this study assessed the expression of the p53 protein, beta-catenin, and her2 and their prognostic implications in patients with ebv-associated gastric cancer (ebvagc). after reviewing 1318 consecutive cases of surgically resected or endoscopic submucosal dissected gastric cancers, 117 patients were identified as ebv-positive using ebv-encoded rna in-situ hybridization. the immunohistochemistry results were interpreted as follows: strong p53 nuclear expression in at least 50% of tumor nuclei was ...201728584793
comprehensive genomic profiling of different subtypes of nasopharyngeal carcinoma reveals similarities and differences to guide targeted date, no targeted therapy has been approved for nasopharyngeal carcinoma (npc), and this underscores the need for an in-depth understanding of clinically relevant genomic alterations (crgas).201728581676
preemptive therapy with rituximab for epstein-barr virus reactivation after haplo-hsct.epstein-barr virus-related post-transplantation lymphoproliferative disorder (ebv-ptld) is a serious complication in hematopoietic stem cell transplantation (hsct) recipients.201728581032
successful resolution of epstein-barr virus-associated hemophagocytic lymphohistiocytosis during the treatment course of acute lymphoblastic leukemia. 201728579038
differential prevalence and correlates of whole blood epstein-barr virus dna between hiv-positive and hiv-negative men who have sex with men in shanghai, china.this cross-sectional study aimed to examine and compare prevalence and correlates of whole blood epstein-barr virus (ebv) dna between hiv-positive and hiv-negative men who have sex with men (msm). five hundred and four hiv-positive msm and 504 age-matched hiv-negative msm were recruited from an hiv counseling and testing clinic in shanghai, china from november 2014 to november 2015 and were administered with a face-to-face questionnaire interview. whole blood ebv dna was tested by nested polymer ...201728578749
unrelated umbilical cord blood transplantation for sickle cell disease following reduced-intensity conditioning: results of a phase i trial.hematopoietic stem cell transplantation from hla-matched sibling donors results in disease-free survival of >90% in patients with sickle cell disease (scd); however, only approximately 18% of these patients have suitable donors available. unrelated cord blood transplantation (ucbt) is one way to expand donor options for patients with severe scd, but historically has been associated with high graft rejection rates (50% to 62%). we hypothesized that the addition of thiotepa to a previously tested ...201728578010
leflunomide/teriflunomide inhibit epstein-barr virus (ebv)- induced lymphoproliferative disease and lytic viral replication.ebv infection causes mononucleosis and is associated with specific subsets of b cell lymphomas. immunosuppressed patients such as organ transplant recipients are particularly susceptible to ebv-induced lymphoproliferative disease (lpd), which can be fatal. leflunomide (a drug used to treat rheumatoid arthritis) and its active metabolite teriflunomide (used to treat multiple sclerosis) inhibit de novo pyrimidine synthesis by targeting the cellular dihydroorotate dehydrogenase, thereby decreasing ...201728574826
haploidentical hematopoietic stem cell transplantation for adult patients with epstein-barr virus-associated hemophagocytic assess the efficacy of haploidentical hematopoietic stem cell transplantation (hsct) in adult patients with epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh), we retrospectively analyzed 30 cases that presented at our institution. at the time of hsct, 20 patients (66.7%) had achieved a response after receiving hlh-94 or salvage therapies. all patients underwent myeloablative conditioning followed by peripheral blood hsct from their related, haploidentical donors. twen ...201728573910
aberrant gene promoter methylation of e-cadherin, p16 (ink4a) , p14 (arf) , and mgmt in epstein-barr virus-associated oral squamous cell carcinomas.the etiology of oral carcinogenesis appears to be multifactorial. there is emerging evidence of the presence of epstein-barr virus (ebv) in epithelial oral squamous cell carcinoma (oscc), but an association of ebv with oral carcinogenesis has not yet been established. although epigenetic alterations, such as aberrant dna methylation, are known to contribute to the pathogenesis of oral cancer, the relationship of such alterations with ebv infection is little known. this study aimed to investigate ...201728573642
clinical significance of overexpression of nrg1 and its receptors, her3 and her4, in gastric cancer patients.neuregulin 1 (nrg1), a ligand for human epidermal growth factor (her) 3 and her4, can activates cell signaling pathways to promote carcinogenesis and metastasis.201728573357
nodal epstein-barr virus-positive t-cell/nk-cell lymphoma associated with immunodeficiency: a rare condition looking for recognition.the authors describe a peculiar form of epstein-barr virus (ebv)-associated t-cell lymphoma in an hiv-positive patient presenting an aggressive clinical course. unlike most other ebv-positive t-cell/natural-killer (nk)-cell lymphomas, the disease was characterized by predominant nodal involvement at presentation. t-cell lineage was confirmed by t-cell receptor-rearrangement, and neoplastic cells exhibited strong and diffuse cd56 expression. a marked intravascular component was detected in the sk ...201728573126
serum ebv antibodies and lmp-1 in polish patients with oropharyngeal and laryngeal cancer.the association between epstein-barr virus (ebv) and the development of head and neck cancer was reported by many researchers. the aim of the present study was to detect ebv dna and ebv antibodies in 110 polish patients with oropharyngeal and laryngeal cancer compared to 40 healthy individuals.201728572837
the 150 most important questions in cancer research and clinical oncology series: questions 31-39 : edited by chinese journal of accelerate our endeavors to overcome cancer, chinese journal of cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. in this article, 9 more questions are presented as follows. question 31: how does aging process inhibit the formation of sarcoma? question 32: is intratumoral morphological heterogeneity the consequence of tumor genomic instability or the cause of aggressive tumor behavior? can we identify more aggressive tumors by c ...201728571582
the role of oxidative stress in ebv lytic reactivation, radioresistance and the potential preventive and therapeutic implications.epstein-barr virus (ebv) is an important cancer causing virus. cancer associated with ebv account for approximately 1.5% of all cancers, and represent 1.8% of all cancer deaths worldwide. ebv reactivation plays an important role in the development of ebv-related diseases and is closely related with patients' survival and clinical stages of ebv-related cancers. the therapy regarding to ebv-related cancers is very urgent, especially in endemic areas. generating oxidative stress is a critical mecha ...201728571118
the effect of adding neoadjuvant chemotherapy to concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma and undetectable pretreatment epstein-barr virus assess the effect of adding neoadjuvant chemotherapy (nact) to concurrent chemoradiotherapy (ccrt) in patients with locoregionally advanced nasopharyngeal carcinoma (npc) and undetectable pretreatment epstein-barr virus (pebv) dna.201728570869
coexistence of lymphoepithelial carcinoma of the parotid gland and submandibular gland pleomorphic adenoma.lymphoepithelial carcinoma is a variant of undifferentiated carcinoma with characteristic dense lymphoid stroma in which nasopharynx is site of predilection. racial and geographic association and epstein-barr virus positivity in endemic areas are other characteristics of this rare neoplasm. lymphoepithelial carcinoma accounts for only 0.4% of malignant salivary gland tumors. the authors present a patient with epstein-barr virus positive lymphoepithelial carcinoma of the parotid gland in a nonend ...201728570397
development of extranodal nk/t-cell lymphoma nasal type in cerebrum following epstein-barr virus-positive uveitis.a 74-year-old woman developed bilateral uveitis with high epstein-barr virus (ebv) dna load in the vitreous fluid without lymphoma cells. four years after the onset, t2-weighted contrast-enhanced mri revealed hyperintense lesions in the right occipital and parietal lobe. a biopsy resulted in the diagnosis of extranodal nk/t-cell lymphoma nasal type (enkl). the repeat region of lmp1, an ebv gene, detected in the brain lesion was identical to that detected in the vitreous fluid. enkl of the centra ...201728566607
drug modulators of b cell signaling pathways and epstein-barr virus lytic activation.epstein-barr virus (ebv) is a ubiquitous human gammaherpesvirus that establishes a latency reservoir in b cells. in this work, we show that ibrutinib, idelalisib, and dasatinib, drugs that block b cell receptor (bcr) signaling and are used in the treatment of hematologic malignancies, block bcr-mediated lytic induction at clinically relevant doses. we confirm that the immunosuppressive drugs cyclosporine and tacrolimus also inhibit bcr-mediated lytic induction but find that rapamycin does not in ...201728566383
[evaluation of viral etiology in central nervous system infections from a university hospital point of view in izmir based on seven years data].the serious diseases of the central nervous system (cns); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. nucleic acid testing (nat) is the tool of choice for viral diagnosis in cns infections. in this study, viral etiological agents found in cerebrospinal fluid (csf) samples sent to our university hospital virology laboratory for laboratory diagnosis of cns infections were retrospectively evaluated and results were compared with ...201728566076
circulating pre-treatment epstein-barr virus dna as prognostic factor in locally-advanced nasopharyngeal cancer in a non-endemic area.the prognostic value of pre-treatment epstein-barr virus (ebv) dna viral load for non-endemic, locally-advanced, ebv-related nasopharyngeal cancer (npc) patients is yet to be defined. all patients with ebv encoded rna (eber)-positive npc treated at our institution from 2005 to 2014 with chemotherapy (ct) concurrent with radiation (rt) +/- induction chemotherapy (ict) were retrospectively reviewed. pre-treatment baseline plasma ebv dna (b-ebv dna) viral load was detected and quantified by pcr. me ...201728562354
her-2/epstein-barr virus crosstalk in human gastric carcinogenesis: a novel concept of oncogene/oncovirus interaction.gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer patients. several investigations reported that her-2 (erbb-2 receptor) and epstein-barr virus (ebv) are important etiological factors in human gastric cancer, where either oncogene/oncovirus alone can derive a major event of cancer progression and metastasis via epithelial-mesen ...201728562165
immunotherapy for esophageal and gastric cancer.pd-l1 upregulation occurs in approximately 40% of gastroesophageal cancers. however, unlike other solid tumors, there is minimal pd-l1 expressed on the cancer cells; rather, expression occurs predominantly on infiltrating myeloid cells. preliminary clinical data involving single-agent pd-1/pd-l1 inhibitors in metastatic gastroesophageal cancer have reported response rates of 22%-27% for patients with pd-l1(+) tumors and 10%-17% for unselected patients. the phase iii ono-4538-12 (attraction 2) tr ...201728561677
barriers to generating pdx models of hpv-related head and neck cancer.delineate factors impacting the creation and use of patient-derived xenografts (pdxs) of human papilloma virus-related (hpv+) head and neck squamous cell carcinomas (hnsccs).201728561270
epstein-barr virus and thyroid cancer: the controversy remains. 201728560569
rna-seq detects pharmacological inhibition of epstein-barr virus late transcription during spontaneous reactivation.the stepwise and sequential expression of viral genes underlies progression of the infectious life cycle. the epstein-barr virus (ebv) is both a tractable model for elucidating principles of transcription as well as a global health threat. we describe an experimental protocol and bioinformatics pipeline for functional identification of ebv true late genes, the last step of transcription prior to virion packaging and egress. all data have been uploaded to the gene expression omnibus under accessi ...201728560170
establishing and applying nomograms based on the 8th edition of the uicc/ajcc staging system to select patients with nasopharyngeal carcinoma who benefit from induction chemotherapy plus concurrent chemoradiotherapy.the subgroups of patients with nasopharyngeal carcinoma (npc) who benefit from induction chemotherapy plus concurrent chemoradiotherapy (ic+ccrt) remain unclear.201728559028
primary vitreoretinal lymphoma -- a review.primary vitreoretinal lymphoma (pvrl) is the most common intraocular lymphoma occurring in the eye. it is a high-grade typically b-cell malignancy, arising in the retina, and is often associated with central nervous system (cns) disease and thereby a poor prognosis. it needs to be distinguished from choroidal low-grade b-cell lymphomas, which do not disseminate to the brain and have a good prognosis. because of the rarity of pvrl, information is lacking regarding its true incidence, its geograph ...201728558176
cancer risk after pediatric solid organ transplantation.the effects of pediatric solid organ transplantation on cancer risk may differ from those observed in adult recipients. we described cancers in pediatric recipients and compared incidence to the general population.201728557749
evidence for the association of epstein-barr virus in breast cancer in indian patients using in-situ hybridization technique.epstein-barr virus (ebv) is etiologically linked to burkitt lymphoma (bl), nasopharyngeal carcinoma, post-transplant lymphomas, hodgkin disease, and possibly other tumors. however, the association of oncogenic ebv with breast carcinoma (bc) is still controversial and a matter of debate. we aimed to study the presence of ebv genome in bc cases in indian patients and its association with the clinicopathological features. the formalin fixed paraffin embedded tissues from 83 women with primary invas ...201728557251
lessons learned: early termination of a randomized trial of calcineurin inhibitor and corticosteroid avoidance using belatacept.the intent of this national institutes of health-sponsored study was to compare a belatacept-based immunosuppressive regimen with a maintenance regimen of tacrolimus and mycophenolate. nineteen primary, epstein-barr virus-immune renal transplant recipients with a negative cross-match were randomized to one of three groups. all patient groups received perioperative steroids and maintenance mycophenolate mofetil. patients in groups 1 and 2 were induced with alemtuzumab and maintained on tacrolimus ...201728556519
a case of ulcerative colitis with squamous cell carcinomas and multiple foci of squamous dysplasia.squamous cell carcinoma (sqcc) in ulcerative colitis (uc) is rare. a 38 year-old japanese woman, who suffered from left-sided uc for 18 years, underwent total colectomy due to sqccs in the rectum and the sigmoid colon. they were well differentiated sqcc, and metastasis was found in the paracolic lymph nodes. multiple small foci of squamous dysplasia (sd) were noted in the rectal mucosa. glandular dysplasia was not found. tp53 was not detected in sd. approximately 40% of cells were immunostained ...201728556347
surgical treatment for epstein-barr virus otomastoiditis complicated by facial nerve paralysis: a case report of two young brothers and review of literature.we report the case of two young brothers with epstein-barr virus (ebv) otomastoiditis complicated by a facial nerve paralysis. the boys, aged 7 months (patient a) and 2 years and 8 months (patient b), were diagnosed with a facial nerve paralysis house-brackmann (hb) grade iv (a) and v (b). after unsuccessful pharmacological treatment, patient a underwent mastoidectomy and atticoantrotomy and patient b underwent a transmastoidal surgical decompression of the facial nerve. they recovered to hb gra ...201728555605
evaluation of the presence of epstein-barr virus (ebv) in iranian patients with thyroid papillary carcinoma.papillary thyroid carcinoma (ptc) is the most common thyroid cancer. ebv is one of the most important viruses related to different types of malignancies. this study investigated the relationship between ebv and papillary thyroid carcinoma.201728554750
de novo collapsing glomerulopathy in renal allograft in association with bk virus nephropathy in a child and stabilization of renal function by elimination of viremia.well-recognized association between hiv 1 infection and collapsing glomerulopathy (cg) raises the possibility that intrarenal infection by other viruses may also contribute to the development of this lesion in native or post-transplant kidneys. there is evidence in literature about association of these lesions with cytomegalovirus, epstein-barr virus, hepatitis c virus, and parvovirus b19 infections. here, we present a case report of post-transplant bk virus nephropathy in a male child who was f ...201728553047
methodological approach to the ex vivo expansion and detection of t. cruzi-specific t cells from chronic chagas disease patients.the discovery of t cell epitopes is essential not only for gaining knowledge about host response to infectious disease but also for the development of immune-intervention strategies. in chagas disease, given the size and complexity of the trypanosoma cruzi proteome and its interaction with the host's immune system, the fine specificity of t cells has not been extensively studied yet, and this is particularly true for the cd4+ t cell compartment. the aim of the present work was to optimize a prot ...201728552984
primary central nervous system diffuse large b-cell lymphoma shows an activated b-cell-like phenotype with co-expression of c-myc, bcl-2, and bcl-6.diffuse large b-cell lymphoma (dlbcl) is the most common non-hodgkin lymphoma, whose main prognostic factor is closely related to germinal center b-cell-like subtype (gcb- dlbcl) or activated b-cell-like type (non-gcb-dlbcl). the most common type of primary central nervous system lymphoma is diffuse large b-cell type with poor prognosis and the reason is unclear. this study aims to stratify primary central nervous system diffuse large b-cell lymphoma (pcns-dlbcl) according to the cell-of-origin ...201728552541
an epstein-barr virus-positive classical hodgkin lymphoma with exclusive sinusoidal growth pattern: an unusual morphologic variant.classical hodgkin lymphoma (chl) typically involves lymph node parenchyma, and a case with hodgkin cells confined within nodal sinusoids is extremely rare. herein we report a case of chl with a sinusoidal growth pattern. this 15-year old patient presented with b symptoms and was found to have bilateral cervical lymphadenopathy and an anterior mediastinal mass. biopsy of a cervical lymph node demonstrated cohesive clusters of reed-sternberg (rs)-like cells suggestive of sinusoidal growth with an ...201728552534
serum ebv ea-iga and vca-iga antibodies can be used for risk group stratification and prognostic prediction in extranodal nk/t cell lymphoma: 24-year experience at a single institution.although extranodal nk/t cell lymphoma (enktcl) is consistently associated with epstein-barr virus (ebv) infection, the manifestation and prognostic value of serum ebv antibodies still remain unknown. one hundred and forty-one patients with enktcl were evaluated for serum ebv ea-iga and vca-iga antibodies levels in the past 24 years in our institution. their correlation with clinicopathological features, plasma ebv dna load, and patients' outcomes was analyzed. ebv ea-iga ≥1:10 and vca-iga ≥1:16 ...201728550598
the enigmatic role of viruses in multiple sclerosis: molecular mimicry or disturbed immune surveillance?multiple sclerosis (ms) is a t cell driven autoimmune disease of the central nervous system (cns). despite its association with epstein-barr virus (ebv), how viral infections promote ms remains unclear. however, there is increasing evidence that the cns is continuously surveyed by virus-specific t cells, which protect against reactivating neurotropic viruses. here, we discuss how viral infections could lead to the breakdown of self-tolerance in genetically predisposed individuals, and how the re ...201728549714
ebv-negative aggressive nk-cell leukemia/lymphoma: a clinical and pathological study from a single institution.aggressive natural killer (nk)-cell leukemia/lymphoma is a systemic nk-cell neoplasm that preferentially affects asians with a fulminant clinical course and is almost always associated with epstein-barr virus (ebv). the data on ebv-negative aggressive nk-cell leukemia/lymphoma are limited. here we report a series of three patients (two caucasians, one african-american) with ebv-negative aggressive nk-cell leukemia/lymphoma from a single institution, including a case diagnosed on post-mortem exam ...201728548121
two sides of the epstein-barr virus (ebv) coin: long-term control of ebv after liver transplantation? 201728544040
the effect of ebv on wif1, nlk, and apc gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.epstein-barr virus (ebv) is an important dna tumor virus that is associated with approximately 10% of gastric carcinomas and 99% of nasopharyngeal cancers (npc). dna methylation and micrornas (mirnas) are the most studied epigenetic mechanisms that can prompt disease susceptibility. this study aimed to detect the effect of ebv on wnt inhibitory factor 1 (wif1), nemo-like kinase (nlk), and adenomatous polyposis coli (apc) gene methylation, and expression in gastric carcinoma and npc. the wif1, nl ...201728543390
viruses and endogenous retroviruses in multiple sclerosis: from correlation to causation.multiple sclerosis is an immune-mediated disease with an environmental component. according to a long-standing but unproven hypothesis dating to initial descriptions of multiple sclerosis (ms) at the end of the 19th century, viruses are either directly or indirectly implicated in ms pathogenesis. whether viruses in ms are principally causal or simply contributory remains to be proven, but many viruses or viral elements-predominantly epstein-barr virus, human endogenous retroviruses (hervs) and h ...201728542724
expression profile of epstein-barr virus and human adenovirus small rnas in tonsillar b and t lymphocytes.we have used high-throughput small rna sequencing to characterize viral small rna expression in purified tonsillar b and t lymphocytes isolated from patients tested positive for epstein-barr virus (ebv) or human adenovirus (hadv) infections, respectively. in the small set of patients analyzed, the expression profile of ebv and hadv mirnas could not distinguish between patients diagnosed with tonsillar hypertrophy or chronic/recurrent tonsillitis. the ebv mir-bart expression profile among the pat ...201728542273
the complexity in herpesvirus entry.enveloped viruses have evolved diverse transmembrane proteins and protein complexes to enable host cell entry by regulating and activating membrane fusion in a target cell-specific manner. in general terms, the entry process requires a receptor binding step, an activation step and a membrane fusion step, which can be encoded within a single viral protein or distributed among multiple viral proteins. hiv and influenza virus, for example, encode all of these functions in a single trimeric glycopro ...201728538165
high levels of il-10 and cd4+cd25hi+ treg cells in endemic burkitt's lymphoma patients.the interplay between epstein-barr virus infection, malaria, and endemic burkitt's lymphoma is not well understood. reports show diminished ebv-specific th1 responses in children living in malaria endemic areas and deficiency of ebna1-specific ifn-γ t cell responses in children with endemic burkitt's lymphoma (ebl). this study, therefore, examined some factors involved in the loss of ebna-1-specific t cell responses in ebl.201528536409
[expression and prognostic significance of microenvironment related prognostic factors in patients with classical hodgkin's lymphoma].objective: to observe the expression of three microenvironment related prognostic factors, i. e. programmed death 1 (pd-1), forkhead box protein 3(foxp3) and colony-stimulating factor 1 receptor(csf-1r) protein in classical hodgkin's lymphoma (chl) patients, and to explore the correlation between the protein expression and the prognosis of the patients. methods: a total of 45 cases of chl patients, who had been admitted to the tianjin medical university cancer institute and hospital and chinese ...201728535626
posttransplant lymphoproliferative disorder: otolaryngological manifestations and management.objective posttransplant lymphoproliferative disorder (ptld) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression and is strongly associated with epstein-barr virus (ebv). otolaryngological findings tend to present early in the clinical course; therefore, disease awareness among otolaryngologists is of utmost importance. this review synthesizes the body of literature pertaining to ptld involving the head and neck, summarizes contemporary management, ...201728535360
clinical and mucosal immune correlates of hiv-1 semen levels in antiretroviral-naive men.this study was done to characterize parameters associated with semen human immunodeficiency virus (hiv)-1 ribonucleic acid (rna) viral load (vl) variability in hiv-infected, therapy-naive men.201728534034
epstein-barr virus-associated smooth muscle tumor as the initial presentation of hiv infection: a case report. 201728532583
is pretreatment epstein-barr virus dna still associated with 6-year survival outcomes in locoregionally advanced nasopharyngeal carcinoma?purpose: the objective of this study was to confirm the association between pretreatment epstein-barr virus (ebv) dna (pre-dna) load and survival outcomes after long-term follow-up in patients with locoregionally advanced nasopharyngeal carcinoma (la-npc). materials and methods: between november 2009 and february 2012, a total of 1036 patients with la-npc were enrolled. there were 762 patients in stage iii and 274 in stage iva-b. all patients were treated with radical radiotherapy with or withou ...201728529609
multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events.fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. fingolimod acts via the sphingosine 1-phosphate (s1p) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. in consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. the drug is safe and effective, and its first hours of use are associated with related to s1p receptors i ...201728528469
casual or causal? two unique cases of hodgkin's lymphoma: a case report and literature review.background immunosuppressive diseases and therapies have long been connected to risk of malignancies, especially lymphoma. with some diseases and drugs, the association is well established but the data is mostly anecdotal because of the rarity of the situation. case report we present 2 rare cases. the first patient had psoriasis, was on etanercept, and developed hodgkin's lymphoma. this case is rare because psoriasis and etanercept do not usually cause lymphoma, and if they do, it is predominant ...201728522794
il-35 expression is increased in laryngeal squamous cell carcinoma and in the peripheral blood of patients.interleukin-35 (il-35) has been proposed as a novel immune-suppressing cytokine. however, the function of il-35 in malignant diseases is yet to be elucidated. the present study investigated il-35 expression levels in laryngeal squamous cell carcinoma (lscc) tissues and the peripheral blood of patients to explore the potential involvement of il-35 in lscc progression. in the present study, il-35 expression levels in tissues and peripheral blood were analyzed by reverse transcription-quantitative ...201728521437
natural variation of epstein-barr virus genes, proteins, and primary microrna.viral gene sequences from an enlarged set of about 200 epstein-barr virus (ebv) strains, including many primary isolates, have been used to investigate variation in key viral genetic regions, particularly lmp1, zp, gp350, ebna1, and the bart microrna (mirna) cluster 2. determination of type 1 and type 2 ebv in saliva samples from people from a wide range of geographic and ethnic backgrounds demonstrates a small percentage of healthy white caucasian british people carrying predominantly type 2 eb ...201728515295
a temporal proteomic map of epstein-barr virus lytic replication in b cells.epstein-barr virus (ebv) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, b cell lymphomas, and oral hairy leukoplakia. we performed systematic quantitative analyses of temporal changes in host and ebv proteins during lytic replication to gain insights into virus-host interactions, using conditional burkitt lymphoma models of type i and ii ebv infection. we quantified profiles of >8,000 cellular and 69 ebv proteins, including >500 ...201728514666
[the detection of the human papilloma virus during hyperplastic processes in the nose, ears and throat].the objective of the present work was to carry out the virological and histological studies of various neoplastic and hyperplastic processes in the nose, ears, and throat with a view to identifying the presence of human papilloma virus and epstein-barr virus. the brush biopsies and remote neoplasms obtained from 18 patients (including 2 children and 16 adults) presenting with various ent diseases and tumours were available for the virological investigation with the use of the polymerase chain re ...201728514365
epstein-barr virus encephalitis in solid organ transplantation.epstein-barr virus (ebv) is typically associated with post transplant lymphoproliferative disease (ptld) after solid organ and stem cell transplantation. however, it is rarely associated with neurological complications. we report a case of severe encephalitis complicating primary ebv infection six months post renal transplantation, and review the literature on ebv encephalitis in solid organ transplantation in adults. a 55-year-old male presented 6 months post cadaveric renal transplant with hea ...201728513810
epstein-barr virus-encoded lmp2a stimulates migration of nasopharyngeal carcinoma cells via the egfr/ca(2+)/calpain/itgβ4 axis.epstein-barr virus (ebv)-encoded latent membrane protein 2a (lmp2a) promotes the motility of nasopharyngeal carcinoma (npc) cells. previously, we have shown that the localization of integrin β4 (itgβ4) is regulated by lmp2a, with itgβ4 concentrated at the cellular protrusions in lmp2a-expressing npc cells. in the present study, we aim to further investigate mechanisms involved in this process and its contribution to cell motility. we show that expression of lmp2a was correlated with increased ep ...201728512118
a case of infantile systemic lupus erythematosus with severe lupus nephritis and ebv infection.infantile systemic lupus erythematosus (isle) is extremely rare. patients with isle usually become severely unwell and have poor prognosis. epstein-barr virus (ebv) infection has been implicated in the development of sle in both adults and children. recently, we experienced a case of isle with severe lupus nephritis (ln) and ebv infection. a 14-month-old japanese boy was diagnosed with isle according to the american rheumatism association criteria. renal biopsy showed ln classified as internatio ...201328509290
post-transplant lymphoproliferative disease in liver transplant lymphoproliferative syndrome (ptld) is a rare and potentially life-threatening complication after liver transplantation. the aim of this study was to analyze the clinicopathologic features related to ptld in a single institution after liver transplantation.201728508661
Displaying items 701 - 800 of 34780