epstein-barr virus, infectious mononucleosis, burkitt's lymphoma and nasopharyngeal carcinoma. 1977200586
[eb virus and infectious mononucleosis]. 1977200773
human virus-infected target cells lacking hla antigens resist specific t-lymphocyte cytolysis. 1977200845
comparison of epstein-barr viral dnas in burkitt lymphoma biopsy cells and in cells clonally transformed in vitro.the nucleotide sequences of intracellular epstein-barr viral dnas in tumor biopsy cells of clones independently transformed in vitro were generally compared by determing the electrophoretic mobilities of restriction endonuclease cleavage fragments of the viral dna. to carry out this comparison, cleaved cell dnas were electrophoresed in agarose gels and transferred to nitrocellulose paper, and the immobilized viral species were identified by hybridization with purified, viral dna labeled in vitro ...1977200925
epstein-barr virus genome carrying lymphocyte subpopulations of human palatine tonsils. 1977200950
viral attributes and host factors in carcinogenesis: herpesviruses.this paper describes two different experiments of nature: 1) the persistence of unusual virus strains of epstein-barr virus (ebv) (which proved oncogenic in vitro) and cytomegalovirus (cmv) in lymphoid cells following congenital or early acquired infection; 2) the occurence of multiple cases of burkitt's lymphoma and nasopharyngeal carcinoma in one family. all the members of this family were ebv viral capsid antigen (vca) and nuclear antigen (ebna) antibody positive. the two patients with nasoph ...1977200983
an italian case of nasopharyngeal carcinoma correlated with epstein-barr virus specific italian case of nasopharyngeal carcinoma was studied clinically; the immunologic study showed the correlation with the epstein-barr virus specific antigen.1977201063
identification of the target cells in human b lymphocytes for transformation by epstein-barr virus. 1977201086
induction of epstein-barr virus-associated early antigen in different lymphoid cell lines with ultraviolet-irradiated p3hr-1 virus. 1977201088
[herpes simplex virus (hsv-1 and hsv-2) infection: its clinical and oncogenic properties (author's transl)].the epidemiology and clinical features of diseases caused by the herpes simplex virus, are reviewed and recent results are discussed which give an insight into the complex mechanism of primary and chronic, recurrent hsv-1 infections. immunological reactions in hsv infection and data concerning the oncogenic potential of hsv-1 and -2 are dealt with. furthermore, current therapeutic possibilities are outlined.1977201107
epstein-barr virus and cytomegalovirus antibodies in infectious mononucleosis.a method has been evolved for the demonstration of epstein-barr virus (ebv) and cytomegalovirus (cmv) infection in 83 cases of infectious mononucleosis. serum samples were tested for ebv igm, anti-vca igg, anti-ebna, cmv igm and cmv igg antibodies. an acute-phase sample (or samples) and a convalescence sample were examined in each case, and in 44 cases an additional samples was examined 5-12 months after the illness. since the different antibodies showed characteristic differences in both titre ...1977201153
congenital infection with cytomegalovirus and epstein-barr virus. 1977201355
establishment of an epstein-barr virus-negative b-cell lymphoma line from a japanese burkitt's lymphoma and its serial passage in epstein-barr virus (ebv)-negative lymphoma line (jbl) was established in vitro from pleural effusion of an ebv-seropositive 29-year-old japanese female with burkitt's lymphoma. jbl cells as well as her original lymphoma cells bore monoclonal surface igm with lambda light chains. the jbl line grew in single cell suspension with a doubling time of 30 hours. attempts were made to serially transplant jbl cells in antilymphocyte serum-treated newborn hamsters; intraperitoneal implantation of 1-3 x ...1977201360
multiple childhood osteosarcomas in an american indian family with erythroid macrocytosis and skeletal anomalies.three of nine children of possibly consanguineous american indian parents developed typical osteosarcoma in a 2-year period. etiologic investigations detected limb anomalies and elevated mean corpuscular volumes (98--109 micrometer3) in the surviving tumor patient, several of her sibs, and her father. limb anomalies included simple clinodactyly with brachymesophalangy, absence of one digital ray of the foot, and bilateral radioulnar synostosis. the red cell macrocytosis was not accompanied by an ...1977201363
transfer factor therapy in ataxia--telangiectasia.the effects of weekly doses of transfer factor in four patients with ataxia--telangiectasia were investigated following a total course of 2 months therapy. transfer factor administration showed no influence on the absolute lymphocyte counts, t-cell rosettes or antibody titres to ebv, but it caused conversion of skin-test reactivity and production of mif to various antigens. there was a dissociation in blastic transformation response, the skin-test responses and mif production. serum interferon l ...1977201409
immunodeficiency to the epstein-barr virus in the x-linked recessive lymphoproliferative syndrome. 1978201410
further studies on the differences in serum dependence in ebv negative lymphoma lines and their in vitro ebv converted, virus-genome carrying sublines. 1977201467
chromosome banding, isoenzyme studies and determination of epstein-barr virus dna content on human burkitt lymphoma/mouse hybrids.four independently fused hybrid clones derived from a cross between the mouse mammary carcinoma ta3ha and the human burkitt lymphoma line daudi were tested for the ebv-determined nuclear antigen (ebna), ebv-dna and the presence of human chromosomes, in the course of serial propagation in vitro. ebna and ebv-dna were lost in parallel with the loss of human chromosomes. it seems that the persistence of eb-viral genetic information does not require the presence of a specific human chromosome(s) in ...1977201572
mechanism of the establishment of epstein-barr virus genome-containing lymphoid cell lines from infectious mononucleosis patients: studies with phosphonoacetate.a concentration of disodium phosphonoacetate (pa) has been defined which will reduce the synthesis of infectious eb virus in a producer cell line to 1% of control values but which will not affect the growth of eb virus-transformed cells in a 12-week colony-forming assay. when total mononuclear cells or t-lymphocyte-depleted mononuclear cells from the blood of acute im patients were cultured in the presence of pa at the above concentration, the regular establishment of eb virus genome-containing ...1977201573
ebv specific secretory iga in saliva of npc patients. presence of secretory piece in epithelial malignant cells.saliva samples from 59 patients with nasopharyngeal carcinoma (npc) and from 20 normal individuals were studied to determine the nature and origin of the ebv-specific iga in npc saliva. about 50% of npc saliva samples contained secretory iga specific for ebv. the corresponding tumor iga(alpha) was found in plasma cells surrounding the epithelial tumor cells and the secretory piece at the surface of epithelial cells. a slightly higher proportion of npc saliva samples containing iga was found in p ...1977201574
comparative studies on the induction of virus-associated nuclear antigen and early antigen by lymphocyte-transforming (b95-8) and nontransforming (p3hr-1) strains of epstein-barr virus. 1978201584
replication of epstein-barr virus: ultrastructural and immunofluorescent studies of p3hr1-superinfected raji cells.we have studied by means of electron microscopy and immunofluorescence the different steps of the replication of the p3hr1 strain of epstein-barr virus in raji cells. the virus entered the cell by fusion of the viral envelope with the plasma membrane, followed by the disintegration of the capsid. in some cases, the migration of nucleocapsids toward the nuclear membrane was observed. the synthesis of new virions began as early as 7 h after infection (in the case of a high multiplicity of infectio ...1977201779
virological aspects of head and neck cancer. 1978201814
epstein-barr-virus immunity and tissue distribution in a fatal case of infectious mononucleosis. 1978201839
non-random chromosome gains in human lymphoblastoid cell lines. 1977201860
possibility of eb virus preferentially transforming a subpopulation of human b lymphocytes. 1977201868
[epstein-barr virus as an etiological factor in infectious mononucleosis and other diseases]. 1977201912
the glandular fever syndrome revisited. 1977201932
oropharyngeal excretion of epstein-barr virus by patients with lymphoproliferative disorders and by recipients of renal an attempt to associate oropharyngeal excretion of epstein-barr (eb) virus with lymphoproliferative disorders other than infectious mononucleosis, we tested throat gargles collected from adult subjects for the eb virus. nine (16%) of 55 healthy persons were positive. high eb virus-excretion rates were found among patients with active acute lymphocytic leukemia (6/6, 100%), among renal homograft recipients during the third to 12th month after transplantation (26/30, 87%), and among critically ...1978202183
persistent infection and viral carrier state of a human lymphoblastoid cell line infected with mumps virus before its transformation. 1977202295
gut lymphoma presenting simultaneously in two siblings. 1978202368
a convenient method of establishing permanent lines of xeroderma pigmentosum cells.nine lymphoblastoid cell lines were established after transformation by epstein-barr virus of peripheral lymphocytes from four xeroderma pigmentosum (xp) patients, the parents of one xp patient, and three normal donors. all these cell lines proliferate as suspension in roswell park memorial institute medium 1640 supplemented with 20% fetal bovine serum, without detectable release of infectious epstein-barr virus. some characteristics of these cell lines, such as growth rates, chromosome numbers, ...1978202381
epstein-barr virus (ebv) receptors, complement receptors, and ebv infectibility of different lymphocyte fractions of human peripheral blood. ii. epstein-barr virus studies. 1978202404
a case of an epstein--barr virus (ebv) genome-carrying lymphoma in an israeli arab child. 1977202470
a new lymphoid cell line, reh 6, with characteristics of non-t and non-b cells, lacking the epstein-barr virus genome and derived from human acute lymphoblastic leukemia.a new lymphoid cell line, reh 6, has been established from the peripheral blood of a patient with acute lymphocytic leukemia. reh 6 cells were assayed for the presence of epstein-barr virus (ebv) dna by nucleic acid hybridization and for epstein-barr nuclear antigen (ebna) by the immunofluorescence test. reassociation kinetics between in vitro [3h]-labeled ebv dna and reh 6 cell dna indicated the absence of detectable amounts of ebv dna in reh 6 cell dna. in addition, attempts to detect ebna by ...1978202576
appearance of early and late components of epstein-barr virus-associated membrane antigen in daudi cells superinfected with p3hr-1 virus.this study investigated the synthesis of membrane antigen (ma) as well as virus capsid antigen (vca) and early antigen (ea) in daudi cells which had been superinfected with the p3hr-1 strain of epstein-barr virus (ebv) and then treated with trypsin to remove initially absorbed ma-positive material from the cell surface. synthesis of ma, vca and ea was completely inhibited by puromycin. a marked reduction in the frequency of ma positive cells was observed in superinfected cells cultured in the pr ...1978202665
cytofluorometry of lymphocytes infected with epstein-barr virus: effect of phosphonoacetic acid on nucleic acid.dna synthesis in epstein-barr virus (ebv)-infected lymphocytes was inhibited by phosphonoacetic acid (paa) as measured by [3h]thymidine incorporation. paa, at a concentration of 200 microgram/ml, inhibited [3h]thymidine incorporation by human umbilical cord lymphocytes infected with ebv strain p94 but had little effect on dna synthesis in mitogen-stimulated cells. transformed cell lines did not develop from infected cord cell cultures treated with 100 microgram of paa per ml. cytofluorometric an ...1978202732
radiobiological inactivation of epstein-barr virus.lymphocyte transforming properties of b95-8 strain epstein-barr virus (ebv) are very sensitive to inactivation by either uv or x irradiation. no dose of irradiation increases the transforming capacity of ebv. the x-ray dose needed for inactivation of ebv transformation (dose that results in 37% survival, 60,000 rads) is similar to the dose required for inactivation of plaque formation by herpes simplex virus type 1 (fischer strain). although herpes simplex virus is more sensitive than ebv to uv ...1978202757
epstein-barr virus and burkitt's lymphoma. 1978202872
epstein-barr virus infection of cryopreserved umbilical cord blood lymphocytes. 1978202978
[chromosomes of 7 transplantable lines of macaque and pavian hematopoietic cells producing herpesvirus type ebv and oncornavirus type c].karyotypes of su-1, su-2, kmma-1, and kmma-2 (producing oncornavirus c-type), and kmpg-1, spf-2, and spg-3 (producing hsv, a virus of ebv type) cell lines were studied in the time course. the lines were derived from hemopoietic cells of brown macaques and baboons bearing lymphomas. some of the lines had a paradiploid-pseudodiploid karyotype, another part aneuploid type. the selectivity of structural and numerical abnormalities of chromosomes 1, 9, 10, 11, 12, 13, 15, 18, and 20 was detected indi ...1977203114
nasopharyngeal cancer in greenland. the incidence in an arctic eskimo population.nasopharyngeal cancer is very common among the chinese in various parts of the world, particularly southern china, and frequent in certain other mongoloid groups in southeast asia. also, the incidence among the eskimos of the western canadian arctic and alaska is considerably higher than would be expected. ths paper reports for the first time the incidence of nasopharyngeal cancer among native greenlanders, an eskimo population with some admixture of caucasian blood. during 1955-1976, thirty-fiv ...1977203161
infectious mononucleosis and the epstein-barr virus.recent elucidation of the relationship between the epstein-barr virus and infectious mononucleosis has resulted in the development of new diagnostic serological tests, and has amplified our knowledge of the epidemiological and clinical aspects of the disease. the history, epidemiology, clinical characteristics, diagnostic features, and therapy of infectious mononucleosis are reviewed. this is done in the light of recent knowledge concerning the epstein-barr virus as well as previous studies empl ...1978203184
tonsillectomy and infectious mononucleosis.tonsillar tissue may be the primary site of infection with epstein-barr virus (ebv), the etiologic agent of classical infectious mononucleosis (im). therefore, a retrospective study of the association between tonsillectomy and im was performed in a college student population. in the first part of the study, tonsillectomy rates were compared between 164 im-positive students and 164 student controls who attended ucla in 1972-1975. although it was determined that the development of im during colleg ...1978203187
large-scale production and concentration of infectious epstein-barr virus.infectious epstein-barr virus (ebv) was produced from suspension cultures of p3hr-1 cells. a protocol for the scaled-up production and concentration of the virus was developed. virus from the culture fluid was concentrated by continuous-flow pelletization or continuous flow with banding in sucrose. ebv prepared by pelletization yielded 1.7 x 10(4) infectious units/ml (100 x concentration) and less than 3.4 x 10(7) evb particles/ml (1,000 x concentration), whereas ebv prepared by banding yielded ...1978203227
blastogenic response of purified human t-lymphocyte populations to epstein-barr virus (ebv).the blastogenic response of t-cell populations to infectious ebv (b95-8 strain) was studied. the addition of virus increased the [3h]thymidine uptake of unfractionated lymphocytes from seropositive and seronegative subjects, and from cord blood, but not from patients with infectious mononucleosis. the same amount of virus evoked a small response in purified t cells from seropositive donors, but not in t cells from the other sources. the addition of autologous b lymphocytes with ebv adsorbed on t ...1977203426
induction of ebna precedes the first cellular s-phase after ebv-infection of human lymphocytes.using a combination of immunofluorescence and autoradiography, we studied the appearance of ebna and dna synthesis in cord-blood lymphocytes after infection with ebv derived from the b95-8 cell line. ebna appeared between 12 and 25 h after addition of the virus. dna synthesis was detected in ebna-positive cells approximately 20 h after the appearance of ebna. this shows that ebna induction precedes the first cellular s-phase and suggests that the cells have not yet entered the cell-division cycl ...1978203544
two e-rosette-forming lymphoid cell lines.two e-rosette (spontaneous rosette with sheep red blood cells)-forming lymphoid cell lines were established. one (hpb-all) was derived from a young male japanese patient with acute lymphoblastic leukemia (all), and the other (hpb-mlt) was from a 62-year-old female japanese patient with a leukemic t-lymphoid malignancy. formation of e rosettes, absence of any immunoglobulin determinants, absence of ebna (epstein-barr virus associated nuclear antigen) and very limited stimulating ability in mixed ...1978203546
immune function in healthy relatives of patients with malignant disease.immune function studies of healthy members of families with multiple lymphoreticular neoplasms were compared with those of healthy members of families with multiple cancers and families with no known history of cancer. the lymphoma family group had a significantly elevated serum level of igm and diminished responses to the candida albicans skin test antigen and the t-cell mitogen concanavalin a. subjects with epstein-barr virus-viral capsid antigen titers greater than or equal to 160 had lower r ...1978203705
epstein-barr virus-associated and other antiviral antibodies during intense bcg administration to patients with burkitt's lymphoma in remission.patients with burkitt's lymphoma in chemotherapy-induced remission received through dermal scarifications one or two doses per week of approximately 3 x 10(8) living bcg organisms (pasteur institute vaccine). this treatment was always followed by usually rapid increases by 1--4 log2 steps in the antibody titers to epstein-barr virus (ebv)-associated cell membrane antigens. titer increases of less than 2.5 log2 steps within the first month after the start of bcg treatment correlated with a signif ...1978203706
[lymphoma and eb virus]. 1977203730
[infectious mononucleosis (author's transl)]. 1977203731
production of antibody to tetanus toxoid by continuous human lymphoblastoid cell lines.peripheral lymphocytes from human volunteers boosted with tetanus toxoid were cultured after in vitro infection with epstein-barr virus. forty-four continuous lymphoblastoid lines were established which continued to secrete human gamma globulin; seven of these secreted antibody to tetanus toxoid. subcultures derived from limiting dilution experiments continued to secrete the antibody. some of these antibody-secreting cells have been in continuous culture for more than 6 months.1978204013
latent characteristics of selected herpesviruses. 1978204166
heterophil-negative infectious mononucleosis and mononucleosis-like illnesses. laboratory confirmation of 43 cases. 1977204189
established cell lines as tools in the study of human lymphoma and myeloma cell characteristics. 1977204545
characterization of "t" and "non-t" cell lines established from children with acute lymphoblastic leukemia and non-hodgkin lymphoma after leukemic transformation. 1977204546
establishment and characterization of a truly leukaemic cell line. 1977204547
characterization of a human hodgkin cell line and a lymphoblastic ebna-negative cell line derived from a non-hodgkin lymphoma patient. 1977204548
autoradiographic detection of the epstein-barr virus (ebv)-associated early antigen (ea) in lymphoblastoid cell lines. 1977204549
lymphoid cell lines: in vitro cell markers in correlation to tumorigenicity in nude mice.tumorigenicity of lymphoid cell lines of different origin upon xenotransplantation (s.c. and i.m.) in cell concentrations of 1 x 10(6) cell/inoculum into nude mice was correlated to karyotype, presence of the 14 q + marker, ebv reactivity and immunological markers. lymphoblastoid cell lines (lcl), lacking the 14 q + marker failed to produce tumors independent upon diploidy or aneuploidy. lymphoma-type lines of burkitt lymphoma, lymphosarcoma and hodgkins disease-origin, genotypically aneuploid, ...1977204550
non-hodgkin lymphomas: cell populations and functional behavior. 1977204551
establishment of paired tumor cells and autologous virus-transformed cell lines to define humoral immune responses in melanoma and sarcoma patients.peripheral blood lymphocytes and skin fibroblasts from 12 cancer patients were infected with epstein-barr virus (ebv) or sv40 virus. the ebv-transformed lymphoblasts and sv40-transformed fibroblasts were grown as continuous cell lines and expressed the same histocompatibility antigens as tumor cell lines established from the same cancer patients. sera from 350 melanoma and 195 sarcoma patients were tested for antibody reactive with membrane antigens on three of these tumor cell lines (two melano ...1978204583
autoradiographic detection of epstein-barr virus (ebv)-associated early antigen in a variety of ebv dna-containing lymphoblastoid cell lines previously designated as using autoradiography combined with 125i-labeled igg prepared from human sera containing high anti-ea (early antigen) antibody titers, ea has been detected in a low fraction of cells in a variety of ebv dna-containing cell lines previously designated as negative for this antigen. these positive cell lines are highly inducible for ea following treatment with iododeoxyuridine (iudr) and also contain multiple copies of the virus genome on average. the correlation between iudr inducibility and sp ...1978204604
partial purification and properties of the epstein-barr virus-associated nuclear antigen.the epstein-barr virus (ebv)-associated nuclear antigen (ebna) was purified 85-fold from a nuclear pellet derived from an ebv-transformed b lyphoblastoid cell line by a five-step procedure consisting of preparation of extract, heating at 80 degrees c in phosphate buffer, ammonium sulfate precipitation, preparative ultracentrifugation, and affinity chromatography on double-stranded dna-cellulose. the purified complement fixing antigen specifically blocked the anticomplement immunofluorescence ass ...1978204660
laboratory diagnosis of eb virus infection in some cases presenting as 1975 and 1976, 7580 serum specimens were tested for hbsag by the passive haemagglutination test, hepanosticon. serum from 38 people gave a positive result after absorption with the absorbent provided, but the presence of hbsag could not be confirmed by other tests. tests for current infection with eb virus, namely, the presence of heterophil antibody and eb virus specific igm, were performed and were positive in 11 of the 38. in six of these the clinical picture was of hepatitis rather than i ...1978204666
[eb virus infections]. 1977204712
epstein-barr (eb) virus genome-containing, eb nuclear antigen-negative b-lymphocyte populations in blood in acute infectious mononucleosis.experiments have been performed to identify the type and size of cell infected by eb virus in the blood of acute infectious mononucleosis (im) patients, and to investigate the nature of the infection. virus-infected cells, recognized by their ability to give rise to lymphoblastoid cell lines when co-cultivated with foetal lymphocytes, were shown to be restricted to the b-lymphocyte population. samples of this population from each of eight im patients were found to be negative for eb nuclear anti ...1978204732
antibody to epstein-barr virus in patients with carcinoma of the nasopharynx. 1977204823
persisting oncogenic herpesvirus induced by the tumour promotor tpa. 1978204874
properties of epstein-barr virus transformed woolly monkey lymphoblastoid cell lines. 1978204945
[infectious mononucleosis. 6. infectious mononucleosis with thrombocytopenia]. 1978205051
[adenomegalic cytophagic sinusal histiocytosis. morphological and immunologic study of a case].the case of a 14-year-old boy of north-african origin, presenting a phagocytic sinus histiocytosis is reported. the main features of this now classical disease are illustrated: its localization to the neck, its chronicity, the fact that it is well tolerated, the pseudotumoral appearance of the adenomegaly as well as the intensive phagocytic (essentially lymphocytophagic) activity of the sinus macrophages. the bringing to light in a picture of hyperimmunity of an elevated percentage of antibodies ...1978205185
factors affecting serum iga antibody to epstein-barr viral capsid antigens in nasopharyngeal carcinoma.irrespective of the ethnic origin of the patient, nasopharyngeal carcinoma (npc), appears to stimulate the production of iga antibodies against vca. these antibodies are detected at high frequency and titres in sera from npc patients but only rarely from control subjects. a majority of relapse-free survivors tested 1-12 years after radiotherapy (rt) sustain a detectable level of iga anti-vca. serum titres of iga anti-vca remain relatively unchaged in individual npc patients after rt, regardless ...1978205232
an immunologic basis for detection of occult primary malignancies of the head and neck.after extensive evaluation of patients with metastatic neck disease and clinically undetectable primary cancer of the head and neck, the clinician is often faced with the difficult question of subsequent management. in this study, sera from 11 patients with clinically occult carcinoma and metastatic lymphadenopathy were studied for epstein-barr virus-associated antigens. these were compared with 35 sera from patients with known nasopharyngeal carcinoma at all stages of disease and treatment and ...1978205337
ocular granulocytic sarcoma (chloroma) with acute myelomonocytic leukemia in turkish a series of 166 leukemic children from turkey, 56 had acute myelomonocytic leukemia (amml). seventeen boys and 3 girls presented with chloroma-like deposits (granulocytic or myeloid sarcomas) in the eye and orbit, all showing amml on initial study of blood and marrow. the ocular lesions responded rapidly to antileukemic therapy. laboratory studies of amml cases revealed no cytogenetic or immune defects, and epstein-barr virus titers were normal. a group-specific (gs-3) antigen (type-c virus?) ...1978205341
characterization of a unique cell line (laz 221) from human acute lymphocytic ("null" cell) leukemia.a unique human cell line designated laz 221 has been established from the peripheral blood of a patient with acute lymphocytic leukemia of the "null" cell type. the cell line does not possess the epstein-barr virus nuclear antigen and has a karyotype of 45,xx,-9,-12,+(9q12q). both the established cell line and the patient's uncultured blast cells share the same phenotypic markers. they both lack t-cell markers. they fail to form sheep erythrocyte rosettes and do not react with t-cell-specific an ...1978205365
epstein-barr virus-determined nuclear antigen in malignant epithelial cells of nasopharyngeal carcinoma.tumor tissue from lymph node metastasis of nasopharyngeal carcinoma (npc) was successfully heterotransplanted into an athymic nude mouse and the tumor grown in the nude mouse was identical in its morphology to that form the patient by optical and electron microscopy. tumor cells at passage 2 were dispersed in vitro by enzymic digestion and smeared. epstein-barr virus-determined nuclear antigen (ebna) was demonstrated in malignant epithelial cells of the smear.1978205477
[hepatology and immunology].immunologic diseases of the liver are exogenous mostly initiated by virus or endogenous initiated by autoaggression. all virus-induced kinds of hepatitis are due to an immune response against inocculated hepatocytes. therefore the hepatitis is limited to the period of complete elimination of virus-infected cells. a strong immune response therefore corresponds with an acute and short hepatitis whilest a weak immune response develops a chronic hepatitis. in contrast, autoimmune hepatitis based on ...1978205495
heterophil antigen in bovine sera detectable by immune adherence hemagglutination with infectious mononucleosis sera.bovine sera for tissue culture use were shown to contain heterophil antigen of the paul-bunnell-davidsohn type by immune adherence hemagglutination tests with sera from patients with infectious mononucleosis. the antibody titers observed were comparable to those determined by two other methods; i.e., the immune adherence hemagglutination test was found to be as specific as the differential absorption test with horse erythrocytes or the ox cell hemolysis assay,but it appeared to be the most sensi ...1978205510
studies on cytotoxicity generated in human mixed lymphocyte cultures. i. time course and target spectrum of several distinct concomitant cytotoxic activities. 1978205612
epstein-barr virus-immune complexes in postmortem kidneys from african patients with burkitt's lymphoma and american patients with and without lymphoma. 1978205665
state of epstein-barr virus dna in an american burkitt's lymphoma line.a human lymphoma cell line, positive for the epstein-barr virus (ebv)-associated nuclear antigen, was recently established from a north american burkitt's lymphoma. this cell line, su-amb-2, contained ebv dna both in the form of circular, nonintegrated dna molecules of viral genome length, present in multiple copies per cell, and as integrated sequences. having dna present in both of these forms, it resembled cell lines established from african burkitt's lymphomas. in studies on ebv strain diffe ...1978205666
integrated viral dna sequences in epstein-barr virus-converted human lymphoma lines.most human lymphoid cell lines contain multiple copies of circular, nonintegrated epstein-barr virus (ebv) dna molecules as well as viral dna sequences with properties of integrated dna. the physical state of the ebv dna in a human lymphoma line that only contains one virus genome equivalent per cell has now been studied by three different methods, neutral cscl density gradient centrifugation, actinomycin d-cscl gradient centrifugation, and hirt fractionation. this cell line, aw-ramos, has been ...1978205668
a new tumour-derived transforming strain of epstein-barr virus. 1978205793
epstein-barr virus is not synonymous with infectious mononucleosis. 1978205830
differences in expression of surface marker characteristics on epstein-barr virus-transformed human and simian lymphoid cell lines.human lymphoblastoid cell lines transformed in vitro by the epstein-barr virus (ebv) had receptors for fixed complement detectable by a rosette test. ebv transformed cells derived from cotton-topped marmoset leukocytes did not express this receptor. evidence is presented that both human and marmoset cell lines arose from precursor cells which have complement receptors. our findings suggest that transformation of marmoset leukocytes by ebv results in the loss of a differentiated surface marker.1978205852
characteristics of cell lines established from epstein-barr virus induced marmoset tumors.the inoculation of a cotton-topped marmoset with b95-8 strain of ebv resulted in the induction of a multifocal lymphoma and lymphoblastoid cell lines were established from liver, spleen and mesenteric lymph node tumors. the cell lines were remarkably similar to each other with respect to the presence of ebv and its expression, the surface properties of the cells and their stability, and the functional products of the cells. karyotypic examination of the cell lines revealed the common loss of a s ...1978205853
susceptibility of marmosets to epstein-barr virus-like baboon herpesviruses.epstein-barr virus (ebv)-like herpeviruses, strains of herpesvirus papio (hvp), have recently been isolated from lymphomatous (hvp-l) and from normal baboons (hvp-n). both hvp isolates infect some species of marmosets, hvp-l inoculated adult animals develop a mild to severe and sometimes fatal lymphoproliferative disease whereas newborn marmosets of the same species do not develop a measureable disease after inoculation with hvp-l. hvp-n infects adult marmosets but does not cause disease.1978205854
overview of viral oncology studies in saguinus and callithrix species.marmoset monkeys are highly susceptible to tumor induction by type c sarcoma viruses and primate lymphotropic herpeviruses. six experimental models were reviewed, three sarcoma models induced by rous, feline or simian sarcoma viruses and three models of lymphoproliferative disease induced by herpevirus saimiri, h. ateles or epstein-barr virus. relative susceptibility of cotton-topped (saguinus oedipus oedipus), white-lipped (s. nigricollis, s. fuscicollis subspecies) and commone (callithrix jacc ...1978205860
transforming activity of epstein-barr virus obtained by superinfection of raji cells.epstein-barr virus obtained by superinfection of raji cells with epstein-barr virus recovered from p3hr1 cells (hri virus) transformed human lymphocytes, but it did not superinfect raji cells. a human lymphoblastoid cell line, hlb, established by such transformation contained 22 epstein-barr virus genomes per cell and epstein-barr virus-associated nuclear antigen, and a few cells contained early or viral capsid antigen complexes. chromosomal analysis revealed that hlb-cells were diploid with nor ...1978205877
nasopharyngeal carcinoma. 1978205903
the immunological approach to study of possibly virus-induced human malignancies using the epstein-barr virus as example. 1978205906
an assessment of the possible role of viruses in the aetiology of burkitt's lymphoma. 1978205908
[studies on the etiology and course of acute virus hepatitis: analysis of hbs-antigens, anti-hbc, ebv and cmv antibodies]. 1977206062
posttransplantation syndrome in children: cytomegalovirus vs epstein-barr virus. 1978206131
increased myeloid-associated enzymes in epstein-barr virus nuclear antigen--positive human cell lines exposed to butyric acid in vitro. 1978206299
ebv-related cytotoxicity of fc receptor negative t lymphocytes separated from the blood of infectious mononucleosis patients.epstein-barr virus (ebv) related specific killing was demonstrated previously in the t cell enriched subpopulations of blood lymphocytes of im patients. in the present work we demonstrate that the cytotoxic cells belong to the fc negative t subset. t cells in the blood of im patients can be divided in 2 categories, 1 fc positive with non discriminative cytotoxicity and the other, fc negative with selective cytotoxicity against ebv genome carrying lymphoblastoid cell lines.1978206347
detection of the ebv-determined nuclear antigen (ebna) in burkitt's lymphoma and nasopharyngeal carcinoma biopsies by the acid fixed nuclear binding (afnb) technique.epstein-barr virus (ebv) carrying biopsies of burkitt lymphoma (bl) and nasopharyngeal carcinoma (npc) were used to examine the question whether the ebv-associated nuclear antigen (ebna) can be demonstrated by the acid fixed nuclear binding (afnb) technique, developed previously for the demonstration of ebna in cultured cell lines [11]. extracts of 5 bl and 5 npc biopsies gave a brilliant, ebna specific fluorescence after binding to acid fixed chicken red cells. similar extracts of 3 other afric ...1978206349
the detection of epstein barr virus antibody in 'exanthematic' dermatoses with special reference to pityriasis lichenoides. a preliminary survey. 1978206394
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