immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: contrasting consequences of host versus tumor evolution.spontaneous tumours are defined as tumors that develop in the absence of all experimental interference. in contrast to the widely documented, strong rejection reactions against most virus-induced tumors, spontaneous tumors evoke little or no detectable rejection reaction in intact or preimmunized syngeneic hosts. the difference can be viewed in relation to the contrasting natural history of the two conditions. spontaneous tumors evolve in several steps, as a fule. "tumor progression" is a microe ...1977194247
rejectability of virus-induced tumors and nonrejectability of spontaneous tumors: a lesson in contrast to the excellent surveillance against tumors induced by the ubiquitous viruses in their natural host species, spontaneous tumors developing naturally, without experimental interference, evoke little or no rejection reaction. this may be viewed in relation to the natural history of tumors. in most cases, tumors evolve in several steps, with a successful of clonal variants following each other, characterized by increasing independence of host regulations (including immune restrictions) ...1977194366
viral infections in kidney donors and recipients: a prospective study. 1977194367
iga antibodies to epstein-barr viral capsid antigens in saliva of nasopharyngeal carcinoma patients. 1977194619
cold agglutinins in infectious mononucleosis and heterophil-antibody-negative mononucleosis-like syndromes.cold agglutinins (ca) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. cold agglutinins with anti-i specificity were seen mainly in heterophil-positive or -negative epstein-barr virus (ebv)-induced infectious mononucleosis (31.8% of cases). unclassified ca with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (im), in 1 of 7 (14.3%) cases of ...1977194643
relationships between complement activation, complement binding, and ebv absorption by human hematopoietic cell lines. 1977194711
[herpesvirus antibodies in hodgkin's disease and some lympho-hematopoietic diseases in children and adolescents]. 1977194715
comparative immunology of carcinogenesis by dna viruses. 1977194745
clinical implications of immunity to oncogenic viruses. 1977194750
an effect human leukaemic cell line: reh. 1977194778
differential induction of epstein-barr virus-related antigens in heterokaryon cultures.different paterns of induction of epstein-barr virus (ebv)-related antigens were observed in heterokaryons produced by sendai virus-mediated fusion of producer and non-producer human lymphoblastoid cells with various other cell types. ebv-related early antigens (ea) and viral capsid antigen (vca) could obviously be induced in heterokaryons between producer cells (p3hr-1 and qimr-wil), normally expressing these natigens at very low frequency, and human fl or hela cells. positive cells were detect ...1977194844
comparative studies on adult donor lymphocytes infected by eb virus in vivo or in vitro: origin of transformed cells arising in co-cultures with foetal were set up between equal numbers of mononuclear cells from the blood of eb virus-infected individuals, either acute im patients or healthy seropositive adult donors, and foetal cord blood mononuclear cells of the opposite sex. the cell lines arising in the co-cultures were of mixed origin, with foetal cells predominating in many cases. in contrast, when mononuclear cells from seronegative adult donors were first infected with eb virus in vitro and then 5 to 12 days later co-cultured ...1977194845
detection localization of epstein-barr virus-associated early antigens in single cells by autoradiography using 125i-labeled antibodies. (with 1 color plate).a characteristic feature of virus-transformed cells is the expression of virus-specific antigens usually detectable by immunological or radioimmune procedures. we report here an autoradiographic method for the detection and localization of such antigens in individual cells which combines the cellular specificity and radiolabeling sensitivity of the above procedures. as a test system we have studied the reaction between virus antigen in some epstein-barr virus (ebv) dna-containing cell lines and ...1977194866
transforming activity and antigenicity of an epstein-barr-like virus from lymphoblastoid cell lines of baboons with lymphoid disease.two lymphoblastoid cell lines were established from baboons with lymphoid disease. cells of these lines were positive for complement and fc receptors but lacked sheep cell receptors, theraby indicating b-cell origin. the cells contained antigens which cross-reacted with epstein-barr virus (ebv), viral capsid antigen (vca), early antigen (ea) and membrane antigen (ma). both lines released virus with in vitro transforming activity for lymphocytes of several primate species including humans. cells ...1977194867
immune deficiency of t system with possible t cell regulatory activity defect.the occurrence of t system immunodeficiency in an infant together with excessive production of igm and, to a lesser degree, of igg and iga, is an unusual combination. a case is reported in which an unremitting lung infection with lymphadenopathy and hepatosplenomegaly developed in a previously healthy two-month-old infant. leukocytosis with lymphocytosis, monocytosis and eosinophilia was rapidly followed by leukopenia and lymphocytepenia after a blood transfusion for anemia. there was a transien ...1977194869
suppression of in vitro epstein-barr virus infection. a new role for adult human t lymphocytes.studies have been performed on in vitro infection by epstein-barr virus (ebv) of subpopulations of human lymphocytes. b cells of adult peripheral or fetal cord blood transform with equal efficiency, whether assayed by dna synthesis induction or by outgrowth of transformed lymphocytes. in contrast, unfractionated adult lymphocytes transform much less efficiently than those from fetal cord. reconstitution experiments of different cell preparations indicated that this difference was due to a suppre ...1977195004
antibodies to epstein-barr virus in nasopharyngeal carcinoma and other neoplastic conditions.sera from patients with nasopharyngeal carcinoma (npc) or other malignant diseases and from apparently healthy controls were examined for epstein-barr virus (ebv) antibodies. a difference existed in the percentage of positive sera among the groups studied. high-titer antibody levels were observed in the npc group, but no statistical difference was found among other groups of patients and controls. the data reaffirmed the association of ebv with npc but did not support its etiologic role in the d ...1977195074
establishment of an epstein-barr virus-determined nuclear antigen-negative human b-cell line from acute lymphoblastic leukemia.a human b-cell line designated as ball-1 was established from the peripheral blood of a patient with acute lymphoblastic leukemia (all). neither epstein-barr virus (ebv) particles nor ebv-determined nuclear antigen (ebna) was detectable. the morphologic and growth characteristics were clearly distinct from those of numerous ebv-positive lymphoblastoid cell lines previously reported. ball-1 cells probably originated from the donor's leukemia cells as judged from their cytogenetic, morphologic, an ...1977195075
presence of epstein-barr virus receptors, but absence of virus penetration, in cells of an epstein-barr virus genome-negative human lymphoblastoid t line (molt 4).this paper reports a unique type of interaction of epstein-barr virus (ebv) with an ebv receptor-positive, genome-negative human lymphoid t cell line (molt 4), which can be summarized as follows. although molt 4 cells express receptors for ebv, they appear to block the penetration of this virus. these observations are derived from combined studies with immunofluorescence and electron microscopy. it is possible that t cell lines bearing receptors for ebv may express such a control on virus penetr ...1977195091
marked enhancement of interferon production in 5-bromodeoxyuridine treated human lymphoblastoid cells. 1977195215
epstein-barr virus antibodies in multiple sclerosis. 1976195384
infectious mononucleosis and mononucleosis syndromes.infectious mononucleosis (im) and cytomegalovirus (cmv) mononucleosis are caused by a primary infection with related viruses, epstein-barr virus (ebv) and cmv. despite the similarity of clinical manifestations, basic differences exist: (1) the heterophil antibody (ha) response is absent in cmv mononucleosis, whereas it is present in im. (2) in im atypical lymphocytosis reflects proliferation of b cells early and of t cells later in the disease course; in cmv mononucleosis the situation appears c ...1977195404
non-a, non-b hepatitis. 1977195504
parenterally transmitted non-a, non-b hepatitis: an epidemic 1972 a nonsocomial outbreak of parenterally transmitted hepatitis affected both marrow transplant patients and normal platelet donors in an oncology unit. because of the characteristics of the clinical illness, the incubation period of 27 days, and the effect of immune serum globulin on the clinical illness, the outbreak was attributed to hepatitis a; there was no serologic evidence of either hepatitis b virus or cytomegalovirus infection. stored serums from this outbreak were re-examined by ...1977195506
the viral etiology of cancer: a realistic approach.the etiology of cancer resembles that of many other diseases in that multiple factors may be required. because of this, the role or viruses in the etiology of human cancers is especially difficult to assess. when animal tumor systems were used as models, the roles of various predisposing characteristics in virus oncogenesis were elucidated. extrapolation of these findings to the human diseases suggests the importance of genetics, age, hormones, immune competence, and stress in determining suscep ...1977195710
development of cell-mediated immunity to epstein-barr herpesvirus in infectious mononucleosis as shown by leukocyte migration inhibition.eight patients with infectious mononucleosis, aged between 8 and 24, were studied for cell-mediated immunity by the in vitro leukocyte migration inhibition test at acute and convalescent stages. follow-up studies were also carried out at up to 4 months after clinical illness. cell-mediated immunity to epstein-barr virus (ebv) in the peripheral leukocytes from these patients was absent or incipient in all cases during the acute phase, although it was present in lymphocytes from a biopsied lymph n ...1977195902
epstein-barr virus viral capsid antigen titer by immunofluorescence with microplates: new semiautomated method based on the microtiter system.a semiautomated method of an indirect immunofluorescence technique for the titration of antibodies directed against viral capsid antigens of epstein-barr virus has been developed with microtiter system units. by this method, a technician is able to titrate some hundred samples daily. the technique is safe, easy, and reproducible. the various procedures are described, and the sensitivity of the test is discussed.1977195981
dna of epstein-barr virus. ii. comparison of the molecular weights of restriction endonuclease fragments of the dna of epstein-barr virus strains and identification of end fragments of the b95-8 strain.incubation of the dna of the b95-8 strain of epstein-barr virus [ebv (b95-8) dna] with ecori, hsu i, sal i, or kpn i restriction endonuclease yielded 8 to 15 fragments separable on 0.4% agarose gels and ranging in molecular weight from less than 1 to more than 30 x 10(6). bam i and bgl ii yielded fragments smaller than 11 x 10(6). preincubation of ebv (b95-8) dna with lambda exonuclease resulted in a decrease in the hsu i a and sal i a and d fragments, indicating that these fragments are positio ...1977196117
[studies of heterotransplantation of human leukocytes. part ii. heterotransplantation of normal human peripheral leukocytes into hamsters (author's transl)]. 1977196124
a cluster of epstein-barr-virus-associated american burkitt's lymphoma.we investigated four patients in whom histologically confirmed burkitt's lymphomas developed during a one-year period. they were young adults living within 50 km of each other in a rural area of pennsylvania. two patients were related by marriage, but there was no contact with or between the other two. although the majority of american burkitt's lymphomas are not associated with the epstein-barr virus, all four patients showed spectra and titers of antibodies to antigens related to that virus th ...1977196197
replication of ebv in epithelial cells during infectious mononucleosis. 1977196210
[demonstration of epstein-barr virus capsid antigen (vca) in lymphocyte cultures from patients with mononucleosis]. 1977196242
enhanced oncogenic behavior of human and mouse cells after cellular hybridization with burkitt tumor cells.studies were made of the expression of the epstein-barr virus (ebv) in somatic hybrids of burkitt tumor cells and human or mouse cells to determine whether ebv genetic information associated with the capacity to transform leukocytes of human and non-human primates could be maintained and expressed in nonlymphoblastoid cells. data obtained thus far suggest that at least one characteristic associated with cellular transformation (loss of contact inhibition) is expressed only in nonlymphoblastoid c ...1977196293
[infectious and parasitic diseases. survey of the current status in 1977]. 1977196324
heterogeneity of epstein-barr virus. ii. induction of early antigens (ea) by complementation. 1977196397
mechanism of infection by epstein-barr virus. ii. comparison of viral dna from hr-1 and superinfected raji cells by restriction enzymes. 1977196398
simple mathematical deductions in the seroepidemiology of viral infections. i. herpesvirus group (herpesvirus hominis, varicella-zoster virus, cytomegalovris, epstein-barr-virus).large samples of nonselected persons collected in south-west germnay were investigated for the prevalence of serum antibodies to the human herpesviruses hsv, vzv, cmv and ebv. according to "catalytic models", which compare the infection spread to simple chemical reactions of molecules, a mathematical approximation of the serum surveys was performed. through a new deduction of the exponential function y = k (l - e-r+) a simple way was found to estimate the annual attack rates in percent of the su ...1977196453
burkitt's lymphoma of the jaw in a canadian child. 1977196731
spontaneous and induced patterns of the epstein-barr virus (ebv) cycle in a new set of somatic cell hybrids.a somatic cell hybrid line and its subclones obtained by fusing two burkitt lymphoma lines (raji and namalwa) were examined for the expression of ebv-specific antigens both spontaneously and after induction. the hybrids retained spontaneous early antigen (ea) production at the level characteristic of raji. similarly the more permissive raji pattern dominated the induction of ea by iudr treatment or p3hr-1 virus superinfection. these findings accord with our previous results on independently deri ...1977196751
[cytotoxicity of human t-lymphocytes sensitized by epstein-barr virus. role of hla antigens at the surface of target cells infected by the virus].peripheral t-lymphocytes from patients with infectious mononucleosis are cytotoxic towards target cells from epstein-barr virus-genome carrying human lumphoblastoid lines. thus, these t-cells appear to be sensitized to viral coded determinants. daudi cells, that carry ebv-genome, but lack hla antigens are resistant to specific cytolysis in this model. these results suggest direct hla involvement in the target structure recognized by birus-sensitized cytolytic t-lymphocytes in human.1977196780
antibody-dependent cellular cytotoxicity (adcc) against epstein-barr virus-determined antigens ii. induction of adcc by fc-fc receptor bridging.four different methods to test antibody-dependent cellular cytotoxicity (adcc) against epstein-barr virus (ebv) determined antigens were analysed. it was found that optimal adcc was obtained if viral antigens were present during the cytotoxicity reaction and that killing probably was mediated by ebv-related immune-complexes forming fc-fc receptor bridges between fc receptor-bearing effector cells and fc receptor-bearing target cells. only lymphoid target cells with a high expression of fc recept ...1977196801
search for inhibitors against herpes simplex virus type-i in cell extracts derived from human lymphoblastoid cell lines.cell extracts obtained from kb cells and 5 human lymphoblastoid cell lines including 2 from burkitt's lymphoma (p3hr-1 and raji), one each from nasopharyngeal carcinoma (no.223), acute lymphatic leukemia (molt-4) and a healthy person (nc-37) were tested for their inhibitory effects on the growth of herpes simplex virus type-1 (hsv-1) in green monkey kidney (gmk) cells by the plaque titration method. the relationship between the production of hsv-1 inhibitors and the degree of epstein-barr virus ...1977196817
differences in the cona-induced redistribution and agglutination patterns of ebv genome-free and ebv-carrying human lymphoma lines. 1977196869
search for infectious epstein-barr virus-releasing cell lines, with particular reference to a new producer line, a search for infectious epstein-barr virus (ebv)-producer cell sources, 36 ebv genome-carrying lymphoblastoid cell lines originating from various sources in japan were screened. three cell lines derived from different sources were found to release infectious ebv into the culture fluid. ebv from these 3 lines possessed leucocyte-transformation activity but did not induce early antigen formation. one of the three lines, nhad-60, originated from an adenoid tissue; it released a relatively large ...1977196968
infectious mononucleosis: recognition and management.differentiation from other common viral infections depends on a triad of clinical, hematologic, and serologic determinations. a distinctive feature is that while a number of circulating immunoglobulins are often detected, only paul-bunnell antibodies, found in 75% of cases, are specific for im. symptomatic care only is indicated for most patients, though severe cases or complications may require antibiotics or corticosteroids.1977196996
human lymphoblastoid cell lines derived from individuals without lymphoproliferative disease contain the same latent forms of epstein-barr virus dna as those found in tumor cells.the physical state of the intracellular epstein-barr virus dna was characterized in four human lymphoblastoid cell lines, f-265, nc-37, u-303 l, and pg-1, derived from individuals without lymphoproliferative disease. for comparison, a previously investigated burkitt lymphoma line, raji, and a more recently established cell line of that origin, rael, were also studied. the techniques employed were cscl density gradient centrifugation, glycerol gradient centrifugation, and ethidium bromide-cscl de ...1977197024
transformation of lymphocytes by herpesvirus papio.cotton-topped (ct) or white-lipped (wl) marmoset lymphocytes were transformed in vitro with herpesvirus papio (hvp) into permanently growing lymphoblastoid cell lines (lcl). five of 9 hvp-transformed ct cell lines contained cells with antigens reacting with antibodies to epstein-barr virus (ebv) capsid antigen (vca) and/or to ebv-induced early antigens (ea). none of 12 wl lcl revealed such antigen-producing cells. cells from both groups of cultures failed to react with antibodies to the ebv-spec ...1977197025
productive epstein-barr viral infection of the human lymphoblastoid cell line 6410 with release of early antigen inducing and transforming virus.the human lymphoblastoid cell line 6410 was superinfected with p3hr-1 derived epstein-barr virus. subsequent to the first cycle of infection, characterized by early (ea) and virus capsid (vca) antigen synthesis, the culture, designated 6410-ebv, continued to synthesize vca. further immunofluorescence and electron microscopic examination over 18-24 months showed the 6410-ebv culture to be productively infected with ebv. virus was recovered, in quantity, from the culture fluids and assayed for abi ...1977197026
clonal transformation of adult human leukocytes by epstein-barr virus.we have developed a clonal transformation assay for epstein-barr virus which uses adult human leukocytes as target cells. the target cells were isolated from epstein-barr seronegative donors, and the same donor's cells could be studied repeatedly over long periods of time. when these cells were transformed by epstein-barr virus and had proliferated sufficiently to be studied, they had an average cloning efficiency of 3%. assuming this average cloning efficiency obtains at the onset of transforma ...1977197258
burkitt's lymphoma. 1977197352
phenotypic characterisation of a unique non-t, non-b acute lymphoblastic leukaemia cell line. 1977197411
human b cell, t cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias. 1977197412
an immunological basis for inhibition of transformation of human lymphocytes by eb virus. 1977197426
epstein-barr virus: transformation of lymphocytes separated by size or exposed to bromodeoxyuridine and light. 1977197699
transcription of latent epstein--barr virus genomes in human epithelial/burkitt hybrid cells. 1977197704
the herpesvirus group.several agents in the herpesvirus group are known to infect man. they cause a wide variety of conditions, ranging from coldsores to chickenpox and shingles. at the same time a number of the herpesviruses have been linked with malignant diseases in both lower animals and man.1977198052
a comparative study of human cell lines derived from patients with lymphoma, leukemia and infectious mononucleosis: membrane properties, ultrastructure, and surface morphology. 1977198097
the epidemiology of oral cavity, pharyngeal and esophageal cancer outside of north america and western europe.geographical variations in the incidence of oral cavity, pharyngeal, and esophageal cancer were studied, with special reference to rates in countries outside of the united states and western europe. although reporting techniques differ greatly and comparisons must be made with caution, significant variations are evident. tracing such differences often reveals possible etiologic factor for these forms of cancer. the roles are discussed of known environmental carcinogens, such as n-nitroso compoun ...1977198109
solubilisation of epstein-barr virus (ebv)-associated nuclear antigen from raji cells and chromatin by treatment with various molarities of nacl.the solubilisation of epstein-barr virus (ebv)-associated nuclear antigen (ebna) by treatment with various molarities of nacl was investigated using the 125i--igg absorption assay. ninety percent of the antigenic activity detected using the 125i--igg absorption assay was insoluble at 0.15 m nacl. it could be rendered soluble by treatment with 2.0 m nacl, but reprecipitated upon return to 0.15 m nacl. ebna was partially extracted from raji chromatin by treatment with 0.35 m nacl. the efficiency o ...1977198113
cellular immunodeficiency associated with nucleoside phosphorylase deficiency. immunologic and biochemical studies. 1977198175
infectious mononucleosis and fatal myocarditis.mycocarditis is an uncommon manifestation and, very rarely, a lethal complication of infectious mononucleosis. a 14-year-old girl initially had exudative pharyngitis and splenomegaly and developed refractory ventricular fibrillation. the diagnosis of infectious mononucleosis was confirmed by both a strongly positive heterophil antibody test and a high titer of epstein-barr virus. pathologic studies demonstrated extensive histiocytic and lypmhocytic infiltration of the myocardium.1977198186
epstein-barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties.when sensitized leukocytes were re-exposed to ebv antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited ebv-induced transformation and ebv superinfection of target cells. unsensitized leucocytes from sero-negative adults and from neonates did not produce lymphokines when challenge ...1977198380
comparative studies on immunity to ebv-associated antigens in npc patients in north america, tunisia, france and hong kong.this study compared the relative antibody titers to ebv-related antigens in patients with nasopharyngeal carcinoma (npc) and controls from a high-incidence (hong kong), an intermediate incidence (tunisia), and two low-incidence (france, north america) areas to determine which of several ebv antibodies best differentiated npc patients from controls. antibodies measured include anti-virus capsid antigen (vca), anti-early antigen (ea), anti-soluble antigen by complement-fixation (cf) and antibody-d ...1977198381
membrane receptor stripping confirms the association between ebv receptors and complement receptors on the surface of human b lymphoma lines.complement (c3) receptors, ebv receptors, fc receptors, membrane igm and beta2microglobulin (beta 2m) were individually stripped from the surface of human b lymphoma lines. the cells were subsequently tested for their ability to absorb infectious eb virus. stripping of fc receptors, igm and beta2m did not reduce ebv absorption. stripping of either ebv receptors or c3 receptors eliminated or drastically reduced ebv-absorptive capacity. the results confirm the distinctive association between ebv r ...1977198382
diagnostic value of igg and igm antibodies to capsid antigen of epstein-barr virus in infectious mononucleosis. 1977198482
prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts.the prevalence, incidence, and source of infections with different types of herpesviruses were determined prospectively for 25 persons undergoing hemodialysis, 30 allograft recipients, and 16 kidney donors. the prevalence of prior infections with cytomegalovirus (cmv), herpes simplex virus (hsv), and epstein-barr virus (ebv) was high (72%-100%) and was similar for healthy persons and those with renal failure. the incidence of infections in patients undergoing hemodialysis was no greater than tha ...1977198488
detection of soluble antigen of epstein-barr virus by the enzyme-linked immunosorbent assay.the enzym-linked immunosorbent assay (elisa) was compared with the microcomplement-fixation test for sensitivity and reliability in detection of antibody to soluble antigen of epstein-barr virus. elisa was found to be more sensitive (up to 160 times more antibody) in detecting levels of antibody than the complement-fixation assay. the elisa test was shown also to be comparably reliable to the complement-fixation assay in detecting immunity to this antigen; only one false-positive response was fo ...1977198494
some factors affecting the expression of epstein-barr virus-associated membrane antigens.the effect of two factors, l-arginine concentration and phytohemagglutinin (pha) stimulation, on the expression of epstein-barr virus (ebv)-associated membrane antigens (ma) was evaluated. an ebv-producer cell line, av-1, was cultivated in eagle's basal medium with earle's salts, supplemented with various l-arginine concentrations ranging from 0.0 to 20.0 mm. in most of the l-arginine concentrations, the number of cells expressing ma decreased within the first 24 hours. this decrease was followe ...1977198561
epstein-barr virus and nasopharyngeal carcinoma: is there an etiologic relationship?antibody titers to all the epstein-barr virus (ebv)-related antigens were significant elevated (p less than 0.001) in patients with nasopharyngeal carcinoma (npc) compared with those of controls. ebv, early antigen, and anti-diffuse titers of chinese-american and black patients with npc were higher than those of white patients with npc. epstein-barr viral capsid antigen antibody titers were elevated in white patients with squamous cell carcinoma of the pharynx, regardless of subsite. these resul ...1977198562
[factors involved in the development of human tumors using the epstein-barr virus as an example (author's transl)].several viruses induce tumors in animals under experimental or natural conditions. it is likely therefore that some human malignancies are also caused by viruses. proof of this hypothesis can be provided only by indirect evidence based on the following criteria: (1) detection of viral antigens or viral genetic information in a given tumor; (2) transformation of normal human cells by the virus in tissue culture; (3) induction of tumors in animals by the virus; and (4) demonstration of enhanced ti ...1977198603
variable phenotypic expression of an x-linked recessive lymphoproliferative syndrome.investigation of a family with cancer in boys revealed that at least 20 males had the x-linked recessive lymphoproliferative syndrome. a variety of phenotypes occurred: aproliferative phenotypes consisted of aplastic anemia, agranulocytosis or acquired hypogammaglobulinemia; and proliferative phenotypes of b cells included disorders associated with the epstein-barr virus, american burkitt's lymphoma, immunoblastic sarcoma of b cells, fatal infectious mononucleosis or plasmacytoma. the lymphoprol ...1977198660
lymphoma, immunodeficiency and the epstein-barr virus. 1977198662
induction of plaque-forming cells in cultured human lymphocytes by combined action of antigen and eb virus. 1977198668
eb virus-induced b lymphocyte cell lines producing specific antibody. 1977198669
establishment of a cell line with associated epstein-barr-like virus from a leukemic epstein-barr virus like herpesvirus has been isolated from a lymphoid cell line derived from an orangutan with spontaneous myelomonocytic leukemia. herpesvirus has not previously been isolated from this species of higher ape.1977198878
[role of viral agents in the origin of hemoblastosis in primates]. 1977198991
[role of the epstein-barr virus in human diseases]. 1977199027
antibodies to epstein-barr virus capsid antigen and early antigen in nasopharyngeal carcinoma and comparison groups.antibodies to epstein-barr virus capsid antigen (anti-vca) and early antigen (anti-ea) were measured in 263 patients with nasopharyngeal carcinoma (npc), 624 age- and sex-matched neighborhood controls, 570 family members of npc patients and 830 family members of neighborhood controls in taiwan. the distribution of antibody titers was significantly different between npc patients and the other three groups. more than 55% and 45% of npc patients had titers of greater than or equal to 1:640 and grea ...1977199059
recent progress in epstein-barr virus research. 1977199105
null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia.cultured cells established from the bone marrow of a child with null-cell acute lymphoblastic leukaemia (all) have been studied. after 8 months in vitro, the cytological, cytochemical and immunological properties of the cultured cells were very similar to those of the patient's cells. many of the cultured cells had morphological and cytogenetic abnormalities often found in acute leukaemia. the cells were ebna-negative. this unique culture of all-derived null cells might provide information as to ...1977199225
cytotoxicity of circulating leukocytes in cytomegalovirus mononucleosis. 1977199389
relationship between the epstein-barr virus and undifferentiated nasopharyngeal carcinoma: correlated nucleic acid hybridization and histopathological order to examine critically the closeness of association between epstein-barr virus (ebv) dna and nasopharyngeal carcinoma (npc) a correlated histopathological and nucleic acid hybridization study was performed on 51 undifferentiated npc, 4 npc with some signs of squamous differentiation, 7 nasophayngeal tumors of other histological types and 14 head and neck carcinomas located outside the nasopharynx. all 51 undifferentiated npcs contained significant numbers of ebv-genome copies per cell. t ...1977199543
cell mediated immunity during infectious mononucleosis to epstein-barr virus associated antigens.twenty-three patients with recent infectious mononucleosis were studied for cell-mediated immunity to epstein-barr virus (ebv)-associated antigens. by means of a virion-containing antigen preparation, (p3j), leukocyte migration inhibition was demonstrated in 6 of 13 patients with acute infectious mononucleosis (im) and in 6 of 10 patients studied during the convalescent period. inhibition with a soluble antigen (s) preparation was seen in only a few patients at all stages of the illness. lymphoc ...1977199544
a study of cytomegalovirus, epstein-barr virus and herpesvirus hominis (types 1 and 2) antibody in institutionalized and non-institutionalized an attempt to demonstrate differences in antibody prevalence between free-living and institutionalized children, antibodies to cytomegalovirus (cmv), epstein-barr virus (ebv), and herpesvirus hominis (hvh), types 1 and 2, were assayed in 123 children. the children comprised three groups consisting of 41 institutionalized patients with down's syndrome (all non-disjunctive trisomy-g karyotype and equal numbers of age-, sex-, and race-matched non-mongoloid institutionalized subjects and non-inst ...1977199558
unusual prevalence of epstein-barr virus early antigen (ebv-ea) antibodies in ataxia telangiectasia. 1977199670
viral particles in nasopharyngeal carcinoma.lymphoepithelioma of the nasopharynx was identified in a 17-year-old chinese male. the epstein-barr virus titer was 1:3200. tissue from the tumor mass was prepared for electron microscopy. particles consistent with the morphological characteristics of herpes virus were found within the cytoplasm of malignant epithelial cells. this finding is discussed in relation to other data suggesting an oncogenic role of herpes virus in human malignancy.1977199817
primary epstein-barr virus infection in a renal transplant recipient.a young girl with familial nephronophthisis and chronic renal failure contracted a primary epstein-barr virus infection after renal transplantation. during the illness she developed a clinical picture of fever and pneumonitis which closely resembled the posttransplantation syndrome usually associated with cytomegalovirus, although she had no evidence of cytomegalovirus infection. a younger sibling with the same renal disease was found retrospectively to have apparently had an earlier subclinical ...1977199946
alpha-l-iduronidase activity in established lymphoblastoid cells from patients with hurler and scheie syndromes transformed by epstein-barr virus.alpha-l-iduronidase activity was determined in established lymphoblastoid cells, which were transformed in vitro by epstein-barr virus, of lymphocytes-rich cell populations isolated from peripheral blood of patients with hurler and scheie syndromes. alpha-l-iduronidase activities in established lymphoblastoid cells from patients were undetectable, while activities of control subjects were clearly detected. these results suggest that established lymphoblastoid cells are useful for the enzymatic s ...1977199964
virus infections after transplantation in man. brief review. 1977200197
histochemical studies on the ebv-determined nuclear antigen (ebna).the ebv-determined nuclear antigen (ebna) was studied with regard to several histochemical properties. proteolytic enzymes destroyed ebna staining. rnase dnase and hyaluronidase had no effect on the number of ebna positive cells. intensive treatment with dnase weakened the chromosomal fluorescence of ebna, whereas the staining of interphase nuclei was relatively enzyme resistant. when ebv-associated soluble complement-fixing antigen of raji cells (cfa-r) was added to methanolacetic acid-fixed ch ...1977200290
[isoenzyme pattern of acid phosphatase in epstein-barr-virus-dna positive permanent growing lymphoid cell lines (author's transl)].the expression of acid phosphatases is cytochemically one of the most important features in permanent growing b-cell-lines. in few cell lines acid phosphatase is resistant against tartrate. tartrate resistant isoenzyme 5 with components a and b can be demonstrated in monocytes, lymphocytes, chronic lymphatic leucemic cells and especially in hairy cells as well as in cell lines derived from a healthy donor. fractionation of acid phosphatase by gelelectrophoresis in separated lymphocytes demonstra ...1977200294
human leukemic "null" cell line (nall-1).a human lymphoblast cell line, nall-1, was established from the peripheral blood of a patient with acute lymphoblastic leukemia (all). nall-1 cells had neither properties of t and b cells nor epstein-barr virus (ebv). many characteristics of the nall-1 line were distinct from those of numerous ebv-positive lymphoblastoid cell lines previously reported. nall-1 cells are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphologic and functional feat ...1977200333
nasopharyngeal cancer in patients under the age of thirty years.there is evidence that patients under 30 years of age with nasopharyngeal cancer present a somewhat different form of disease than patients of the older age group. serum immunologic reactivity in the former was quantitatively different. histologically, tumors in the younger age group are always of the undifferentiated type, and clinically, the disease is aggressive, characterized by frequent bone and lung metastases. the lymphatic spread into the mediastinum is accompanied by a paraneoplastic sy ...1977200338
biological characterization of an epstein-barr nuclear antigen-positive american burkitt's tumor-derived cell line.two distinct cultures derived from a lymphoid cell line designated nab were characterized immunologically, morphologically, and cytogenetically. both cultures were positive for epstein-barr nuclear antigen. nab i cultures were negative for virus capsid antigen and early antigen and were not affected by treatment with 5-iododeoxyurdine. nab ii cultures were positive for virus capsid antigen and early antigen, which increased with 5-iododeoxyuridine treatment. both cultures were superinfected with ...1977200355
[epidemiology of hodgkin's disease]. 1977200373
isolation of epstein-barr virus from cultured cells of a patient with hodgkin's disease.the suspension lymphoblastoid cell line named chsl-1 was established from the tumor node of a patient with hodgkin's disease. the cells of this culture produce a virus with morphological and physicochemical properties of herpes viruses. immunologic study of the isolated virus demonstrated great similarity with the epstein-barr virus (ebv).1977200451
isolation of infectious eb virus from the epithelial tumour cells of nasopharyngeal carcinoma.evidence of herpesvirus replication has been found by light and electron microscopy in the malignant epithelial cells of two out of six nasopharyngeal carcinomas (npc) examined directly after growth in nude mice to eliminate non-malignant infiltrating cells. the agent has been identified as eb virus by immunofluorescence tests for eb virus capsid antigen, and has been shown to be biologically active by its ability to infect and transform foetal cord blood lymphocytes. lymphoblastoid cell lines w ...1977200568
nasopharyngeal carcinoma: significance of changes in epstein-barr virus-related antibody patterns following therapy. 1977200569
surface glycoprotein patterns of normal and malignant human lymphoid cells. ii. b cells, b blasts and epstein-barr virus (ebv)-positive and -negative b lymphoid cell lines. 1977200571
lymphocyte subpopulations and mitogenic responses in nasopharyngeal carcinoma, prior to and after radiotherapy.eighteen patients with nasopharyngeal carcinoma (npc) were compared to matched controls, before or after cobalt therapy, for the ability of their peripheral blood lymphocytes to: (1) form e and eac rosettes and (2) mount a proliferative response with pha, con a and alg. a slight decrease in the percentage of e rosettes and a moderate hyporesponsiveness to pha and con a were observed before treatment. the statistical significance of these alterations was borderline. within the group of treated pa ...1977200572
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