PMID(sorted ascending)
[tumors caused by viruses]. 1977190098
persistence of herpesvirus nucleic acid in normal and transformed human cells - a review. 1975190112
intracellular forms of epstein-barr virus dna in raji cells. 1975190113
latent genomes of epstein-barr virus.of the ebv dnas in raji cells that contained 50 to 60 viral genomes per cell, 90% were separated from high molecular weight cellular dna by centrifugation in a neutral glycerol gradient after lysis of the cells by treatment with pronase and sarkosyl, indicating that the major portion of the ebv dna in raji cells was not integrated linearly into cellular dna.1975190114
viral rna in cells carring epstein-barr virus. 1975190121
analysis of the dna of epstein-barr viruses and transcriptional products in transformed cells. 1975190122
nucleic acid biosynthesis in nuclei of cell infected with herpesviruses (hsv and ebv).analysis of nuclei isolated from herpes simplex virus (hsv)-infected cells by electrophoresis in polyacrylamide gels showed that only virion-associated dna molecules migrated into the gels. the viral dna molecules, which do not migrate in the gels, are the precursors for the mature viral dna. centrifugation of deoxycholate-treated infected nuclei in sucrose gradients revealed that most of the viral dna co-sedimented with the cellular dna. the dna-dependent rna polymerase activity also co-sedimen ...1975190126
dna synthesis in nuclei isolated from cultured lymphoblastoid cells. 1975190127
studies on the isolation of cell-associated epstein-barr virus antigens by affinity chromatography. 1975190129
virus-induced antigens - a review. 1975190131
the epstein-barr virus (ebv): evidence for ebv strains. 1975190135
preparation of rabbit antisera to epstein-barr virus d-early antigen. 1975190136
studies on the epstein-barr virus (ebv)-associated early antigen (ea) with 125 i-labelled igg. 1975190137
detection of epstein-barr virus (ebv)-associated nuclear antigen in frozen and thawed cells and subcellular fractions of human lymphoblastoid cell lines by means of an 125i-igg binding assay. 1975190139
transformation in vitro by herpesviruses - a review. 1975190141
cell co-operation involved in transformation of leukocytes by the oimr-wil strain of ebv. 1975190142
different properties of cell lines induced by different strains of epstein-barr virus. 1975190143
differences between laboratory strains of epstein-barr virus based on immortalization, abortive infection and interference.biological activities of extracellular epstein-barr virus (ebv) from two laboratory strains, namely p3j-hr-1 (p-h) from burkitt's lymphoma and b95-8 (b95) from infectious mononucleosis, were compared. virus stocks from both sources contained approximately the same number of virions. virus from the p-h line induced early antigen in six non-producer ebv-genome carrier cell lines; virus from b95 did not induce early antigen. extracellular virus from b95 regularly caused lymphocytes from human umbil ...1975190145
appearance of epstein-barr virus nuclear antigen in human cordblood lymphocytes.transformation and induction of ebv-specified ebna was studied in human umbilical cord-blood lymphocytes infected with ebv, hvs or hva. transformation of human umbilical umbilical cord-blood lymphocytes into continuous lymphoblastoid cell lines was successful with ebv derived from five of seven human or simian cell lines but not with hvs or hva derived from simian lymphoblastoid cell lines. ebna induction was studied using b95-8 virus for infection of lymphocytes; as early as 24 hours after infe ...1975190146
expression of viral information - a review. 1975190151
epstein-barr virus: studies on the association of virus genome with human chromosomes in hybrid cells. 1975190152
dna synthesis in cells activated for the epstein-barr virus. 1975190153
replication of cytomegalovirus dna in human lymphoblastoid cells. 1975190154
cytogenic differences between burkitt's lymphoma and other ebv-related human lymphoblastoid cell lines. 1975190155
superinfection with adenovirus of lymphoblastoid cell lines. 1975190157
rna polymerases in human lymphoblastoid cells that contain epstein-barr virus. 1975190159
detection of epstein-barr virus early antigen-d and its antibodies by passive hemagglutination.these data describe the use of a passive hemagglutination test (phat) for the detection of antibodies to the epstein-barr virus (ebv) associated antigen, early antigen-d (ea-d). ea-d was obtained from ebv-superinfected rpmi 64-10 cell preparations which showed by immunofluorescent staining (if) that 25-35% of the cells contained ea-d. solubilization of ea-d was achieved by sonic oscillation, treatment of the pellet-associated material with triton x 100, ammonium sulfate precipitation, and chroma ...1977190173
suitability of epstein-barr virus dna obtained from superinfected raji cells for complementary rna hybridization studies.a method was established to obtain a high yield of epstein-barr virus (ebv) dna for nucleic acid hybridization studies on latent virus dna in transformed cells. superinfection of raji cells with ebv concentrated from hri cell cultures produced a 600-fold higher yield of ebv dna than direct isolation of ebv from hri cell cultures. the virus dna thus prepared from raji cells superinfected with ebv was radioisotopically and spectrophotometrically pure and served as a satisfactory template for the p ...1977190349
antibodies to the r component of epstein-barr virus-induced early antigens in burkitt's lymphoma exceeding in titer antibodies to epstein-barr capsid antigen.african patients with burkitt's lymphoma (bl) may show antibodies to the r (restricted) component of the epstein-barr (eb) virus-induced early antigens that appear to match in titer the antibodies to eb viral capsid antigen (vca) as determined with the aid of acetone-fixed smears of eb3 cells. virus-producing eb3 cells, however, contain the r component as well as vca so that the correct anti-vca titers in such cases remain in doubt. since the r component, but not vca, was found to be denatured b ...1977190417
the owl monkey (aotus trivirgatus) as an animal model for viral diseases and oncologic studies.the owl monkey (aotus trivirgatus) has been shown to be an excellent model for studies of oncogenic and non-oncogenic viruses. studies at this institution have been primarily concerned with herpesvirus saimiri, the epstein-barr virus, h tamarinus, and h simplex. these studies have shown that h saimiri is oncogenic when inoculated into primates, that the malignancy induced by h saimiri can be naturally transmitted from the squirrel monkey to the owl monkey, that in vitro pathogenicity of h saimir ...1976190472
eb virus in the owl monkey (aotus trivirgatus).owl monkeys (aotus trivirgatus) were inoculated with eb (epstein-barr) virus-containing material or virion-free control material. one out of three animals given the virus died after 14 weeks with a reticuloproliferative disease compatible with malignant lymphoma. a cell line was established from an abnormal lymph node of the diseased monkey and was found by electronmicroscopy to carry a herpesvirus identified as eb virus by two types of immunofluorescence test, by its biological behavior and by ...1976190474
evidence for an etiologic relation of the epstein-barr virus to human malignancies.studies on virus-induced animal tumors have provided indirect approaches to a search for viruses causing human malignancies. epstein-barr virus (ebv), the cause of infectious mononucleosis, served to illustrate the usefulness of these approaches in linking ebv with burkitt's lymphoma and nasopharyngeal carcinoma. despite its demonstrated intimate association with these tumors the role of ebv in their causation remains uncertain. while a passenger role seems excluded, it cannot be decided whether ...1977190497
primary epstein-barr virus infections in children.during a serioepidemiologic survey of a community, 13 (6.2%) of 209 children were found to be experiencing a current or recent primary epstein-barr virus (ebv) infection. the sera contained elevated antibody titers to viral capsid antigen of ebv, antibodies to early antigen (ea) of ebv, and specific igm. the frequency of primary infections was highest in the first decade of life. the primary ebv infections were usually asymptomatic. the antibody to ea was directed predominantly to the r componen ...1977190581
expression of red cell bga antigen in children. lack of correlation with previous eb virus infection.the red cell bga antigen and the presence of eb virus antibody were determined in a group of children of mixed ages. evidence of previous infection with eb virus does not correlate with the degree of expression of the bga antigen on red cells.1977190797
cytomegalovirus mononucleosis in a healthy adult: association with hepatitis, secondary epstein-barr virus antibody response and immunosuppression.a 35 year old previously healthy physician had clinical manifestations of a mononucleosis illness complicated by arthralgia, vesicular pharyngitis and hepatitis. initially, the patient had cytomegalovirus (cmv) viremia (predominantly in polymorphonuclear leukocytes) followed by the presence of cmv in the urine, throat and semen. he also had an antibody response to the epstein-barr virus which appeared to be a secondary type. during the acute phase of illness, only 7 per cent of the patient's lym ...1977190884
genital ulceration and infectious mononucleosis: report of a case. 1977190889
epstein-barr virus and human malignancy.the association of the epstein-barr virus and two human malignancies, burkitt's lumphoma and nasopharyngeal carcinoma, is reviewed. seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the epstein-barr virus in these tumors are presented. with our current state of knowledge we cannot conclude that the ipstein-barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its asso ...1977190930
meningoencephalopathy secondary to infectious mononucleosis. unusual presentation with stupor and chorea.we report a case of infectious mononucleosis in which central nervous system involvement was the presenting and sole manifestation of the disorder. the major symptomatology consisted of stupor, chorea, and signs of aseptic meningitis. we also discuss the clinical and laboratory features of the neurological manifestations of infectious mononucleosis and the theories as to its pathogenesis.1977190986
establishment of peripheral lymphoid cell cultures from patients with hodgkin's disease depending on epstein-barr-virus-reactivity and cellular immunity.peripheral blood lymphocytes from 43 patients with hodgkin's disease were studied for spontaneous growth in longterm cultures in vitro. the rate of culture establishment in hodgkin's patients was dependant on a positive epstein-barr-virus (ebv)-seroreactivity and intact delayed hypersensitivity reaction to tuberculin. localized and inactive disease, as well as the absence of atypical mononuclear cells in the peripheral blood had a favourable influence on the longterm in vitro growth. the overall ...1977191123
infectious mononucleosis and fibrosing alveolitis. 1977191141
[burkitt's lymphoma].the burkitt's tumor is a neoplastic disease which occurs mostly in the tropics. sporadic cases however are distributed all over the world. this undifferentiated lymphosarcoma predominates in children. extralymphnodal in origin, quick growth and lack of pain are very characteristic signs. unattended most of the patients die within a few months. cytostatic treatment in connection with x-ray therapy and surgical proceedings show some results. the epstein-barr-virus is incriminated to play a causati ...1977191341
tumour induction in vivo: major events leading to tumorigenesis in embryos inoculated with oncogenic herpesviruses. 1975191353
transformation in vivo - a review. 1975191355
prevention of epstein-barr virus (ebv)-induced infection in cotton-topped marmosets by human serum containing ebv neutralizing activity. 1975191356
response of marmosets to experimental infection with epstein-barr virus.the response of cotton-topped (ct) or white-lipped (wl) marmosets, inoculated with material containing epstein-barr virus (ebv), was studied. twenty-five marmosets inoculated with 10(6)-10(8) cells from human or simian ebv-carrying lymphoblastoid cell cultures developed no detectable clinical disease. transitory antibody titres to vca were detected in sera from several of these marmosets. thirty-eight marmosets inoculated with p3 virus (10(9) particles) and seven marmosets inoculated with 10(5) ...1975191357
observations on the nature of epstein-barr virus infection of peripheral lymphoid cells in infectious mononucleosis. 1975191358
homology of epstein-barr virus dna in nasopharyngeal carcinomas from kenya, taiwan, singapore and tunisia. 1975191360
further studies on the detection of the epstein-barr virus dna in nasopharyngeal carcinoma biopsies from different parts of the world. 1975191361
host responses to herpesviruses - a review. 1975191365
humoral and cellular immunity to ebv and lymphoid cell line antigens in human lymphoma.although elevated antibody levels to the epstein-barr virus (ebv) have been reported in a number of lympho-proliferative neoplasms, it has not been possible to determine whether these antibodies were the result of a specific response to an oncogenic agent (ebv), whether they were a non-specific humoral compensation for depressed cell-mediated immunity (cmi), or whether a different mechanism was responsible. we have previously shown in a group of lymphoma patients that depressed cellular immunity ...1975191366
epstein-barr virus (ebv)-associated antibody patterns in relation to the deficiency of cell-mediated immunity in patients with hodgkin's disease.sera from unselected and untreated patients with hodgkin's disease (hd) were examined for antibodies to epstein-barr viral (ebv) capsid antigens (vca). delayed cutaneous hypersensitivity reactions were carried out with purified tuberculoprotein (ppd). highly purified blood lymphocytes of the same patients were studied morphologically and classified for cell surface markers. incorporation of 14c-thymidine was used as a measure of spontaneous dna synthesis and dna synthesis after exposure to diffe ...1975191367
immunogenetic aspects of nasopharyngeal carcinoma (npc) iii. hl-a type as a genetic marker of npc predisposition to test the hypothesis that epstein-barr virus is an etiological factor in npc.hl-a typing of 144 npc patients and 236 controls revealed an increased frequency of 1st locus hl-42 (relative risk = 2.24) and an increased frequency of unidentified antigens at the 2nd locus (relative risk = 2.60) in the npc patients. hl-a2 and the 2nd locus "blank" appeared to act together (hl-a2 blank haplotype) in determining npc risk in highest-risk cantonese, whereas in relatively lower-risk non-cantonese chinese (hokkiens, teochews) they appeared to act independently. only the "blank" had ...1975191368
auto-antibodies in the sera of patients with nasopharyngeal carcinoma. 1975191369
alteration in epstein-barr virus-human lymphoid cell interactions caused by the presence of type-c viral genome.we have recently established a cell line, designated fvnc, by infection of non-ebv-productive human lymphoid nc-37 cells with the type-c virus flv. the fvnc cell line has been maintained free of detectable ebv- and flv-related immunofluorescent antigens for three years but both viral genomes exist in the cells in a repressed form. the fvnc cells were morphologically similar to the uninfected nc-37 cells but a d-group chromosome change was consistently seen. the colony-forming capacity of fvnc ce ...1975191370
changes in antibodies to epstein-barr virus-associated antigens with the development of burkitt's lymphoma. 1975191371
specific igm response and characteristics of the lymphoblastoid cell lines obtained from an infant with probable mixed cytomegalovirus and epstein-barr virus infection. 1975191372
sero-epidemiology of the epstein-barr virus: preliminary analysis of an international study - a review.samples of chinese, indian, african and caucasian populations, randomly selected in hong kong, singapore, the west nile district of uganda, and nancy, france, were titrated for antibodies to ebv, viral capsid (vca) and complement-fixing soluble (cf/s) antigens. the age-specific prevalence of infection (as reflected by the proportion of vca-positive individuals) varied greatly up to the age of 10 years in the four populations studied, the west nile district of uganda being outstanding in having a ...1975191375
a summing-up. 1975191380
association of epstein-barr virus and american burkitt's lymphoma. 1975191381
antibodies to herpesviruses in patients with cervical cancer and controls.the indirect immunofluorescent test was used to detect antibodies to herpesviruses types 1 and 2, cytomegalovirus and ebv in sera from patients with cervical carcinoma, condyloma acuminatum and controls from cali, colombia, and a control group from the usa. no significant differences were found in the prevalence of antibodies to viral capsid antigens of hsv-1 and cmv among the groups studied. however, titres for hsv-2 were higher in the three groups from cali (cervical carcinoma, condyloma and c ...1975191382
studies on the significance of epstein-barr virus-specific igm in human sera. 1975191384
heterogeneity of epstein-barr virus originating from p3hr-1 cells. i. studies on ebna induction.infection of ebv-negative human b-lymphoma cells of the lines bjab and ramos with ebv from p3hr-1 or b95-8 cells resulted in gradual conversion of these cells to ebna synthesis. whereas b 95-8 virus-infected cells exhibited a uniform brilliant ebna fluorescence, two distinct fluorescence patterns were observed in p3hr-1 virus-converted bjab and ramos cells, a faint granular and a brilliant fluorescence, with predominance of the faint granular pattern. cloning of p3hr-1 virus-converted bjab cells ...1977191406
lymphocyte responses to ebv-associated antigens in infectious mononucleosis, and hodgkin's and non-hodgkin's lymphoma patients, with the leukocyte adherence inhibition assay.the leukocyte adherence inhibition (lai) assay was utilized as a test for cellular immunity to epstein-barr virus (ebv) antigens in 22 patients with infectious mononucleosis (im), 47 patients with lymphoma, 101 carcinoma patients, and 84 subjects without cancer. response to eb virion ("v") antigen was generally present at the time of diagnosis in the im patients but the response to eb soluble ("s") antigen was delayed. an increased cmi response to "v" antigen was found in patients with im, hodgk ...1977191408
epstein-barr virus antibodies in tonsillar carcinoma patients;.sera from 18 tonsillar carcinoma patients and from 18 matched control subjects were examined for the presence of antibodies to viral capsid antigen (vca), early antigen (ea) and nuclear antigen (ebna) of eb virus. antibodies to all three antigens were found more frequently and in significantly higher titres in the tonsillar carcinoma patients than in control subjects.1977191412
column separation of viral capsid antigen (vca)-positive cells from vca-negative cells in an epstein-barr virus (ebv)-producing lymphoid line,.virus producing, vca (viral capsid antigen)-positive cells could be selectively removed from epstein-barr virus (ebv)-carrying, virus-producer p3hr-1 cultures by two different methods of column passage. in the first, the virus-producing cells were covered with human ebv antibody and subsequently passaged through anti-human-ig columns. in the second methods, untreated p3hr-1 cells were allowed to pass through columns of ebv receptor-positive cell lines or, as controls, ebv receptor-positive cell ...1977191413
endogenous reactivation of epstein-barr virus a prior systematic community survey, 20 adults were found to have antibodies to viral capsid antigen (vca) and early antigen (ea) of epstein-barr virus (ebv) in serum. the presence of the latter antibody suggested a recent response to ebv. in the present study the significance of antibody to ea was more extensively evaluated by examination of the sera of these adults for the presence of ebv-specific igm antibodies (ebv-igm) and antibodies to ebv nuclear antigen (ebvna). sera of a matched grou ...1977191540
effect of adenine arabinoside on epstein-barr virus in vitro.the effect of adenine arabinoside (ara-a) on epstein-barr virus (ebv) in cultures of lymphoid cells was examined with use of an ebv-producing cell line, p3hr-1, and a nonproducing cell line, raji. the presence of ebv-associated viral capsid antigen (vca) and early antigen (ea) was detected by indirect immunofluorescence. ara-a inhibited the expression of vca in p3hr-1 cells at concentrations fivefold below those that inhibited cell multiplication; there was no concomitant accumulation of ea. ara ...1977191542
relationship between amount of epstein-barr virus-determined nuclear antigen per cell and number of ebv-dna copies per cell. 1977191759
problems in the diagnosis and treatment of infectious mononucleosis. 1977191799
host-determined differences in expression of surface marker characteristics on human and simian lymphoblastoid cell lines transformed by epstein-barr an attempt to account for differences in the biologic behavior of epstein-barr virus in different primate species, we studied lymphocyte surface markers on primary and transformed cells. among primary leukocytes, the distribution of cells with characteristics of bone-marrow-derived cells (b cells) was similar in humans, wooly monkeys, and cotton-top marmosets. however, after transformation by epstein-barr virus, cells from each species were characterically different. transformed human umbilic ...1977191824
predictors of the duration of infectious mononucleosis.the clinical course of infectious mononucleosis was monitored in 122 patients to determine predictors of duration of illness. gastrointestinal symptoms and palatal petechiae were associated with a prolonged recovery period. multiple regression analysis of quantitative data identified the number of days from onset of symptoms to diagnosis as the only statistically significant indicator. liver enzymes, white blood cell count, percentage atypical lymphocytes and heterophil titer had no prognostic v ...1977191934
infectious mononucleosis: seasonality in wisconsin. 1977191996
[immunoglobulins and sheep red cell receptors in human lymphoblastoid cell lines simultaneously carrying epstein-barr virus and cytomegalovirus genomes].in this communication we attempt to characterize the principal immunological properties of 3 human lymphoblastoid cell lines (lcl) established in our laboratory which carry both the ebv and cmv genomes. the data obtained suggests that two lcl are representative of b lymphocytes while the other lcl has a mixed cell population with the majority being of the b type. the reasons for this heterogeneity are discussed. it is suggested that cmv may also transform thymus-independent (b) lymphocytes.1977192131
[tumour antigens inducing immune reactions].antigens of viral tumours are the same for all the tumours due to the same virus. antibodies in tumours bearing animals allow to detect antigens in nucleus, in cytoplasm and on the cell membrane which carries also embryonic antigens and the antigen responsible for tumour rejection by sensitized lymphcytes (tsta or tata). is this antigen identical to the surface antigen shown by antibodies? purification of membrane antigens will answer this important question. chemically induced tumours bear tumo ...1977192132
cold lymphocytotoxic antibodies in nasopharyngeal carcinoma.sera from patients with nasopharyngeal carcinoma (npc), a disease associated with epstein-barr virus (ebv), were found to be cytotoxic at 15% degrees c in the presence of complement for a panel of human lymphocytes, with a higher frequency than those of matched controls. the cold lymphocytotoxic antibodies (lta) responsible for this activity have the same properties as those described in sera from individuals with acute viral infections. the frequency and geometric mean titres (gmt) of lta varie ...1977192260
monozygotic triplets with discordance for diabetes mellitus and diabetic microangiopathy.a set of monozygotic triplets (pe.k., p.k., s.k.) has been studied. there is no diabetes in first-degree relatives. pe.k. developed insulin-requiring (60 u. nph) diabetes at the age of 13 years. over a period of 11 years since that time, numerous studies of insulin and growth-hormone secretion were performed on p.k. and s.k., including multiple oral glucose tolerance tests (ogtts), cortisone-primed oral glucose tolerance tests (c-ogtts), intravenous glucose tolerance tests (ivgtts), and intraven ...1977192616
lymphoma in cotton-top marmosets after inoculation with epstein-barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral dna, and characterization of viruses.6 of 20 cotton-top tamarins (saguinus oedipus) inoculated with epstein-barr virus (ebv) developed diffuse malignant lymphoma resembling reticulum cell or immunoblastic sarcoma of man. hyperplastic lymphoreticular lesions were induced in three additional animals; in two instances the hyperplastic lesions regressed. inapparent infection with development of antibody occured in eight animals. in two animals there was no evidence of ebv infection. one animal died in the first week after inoculation o ...1977192829
epstein-barr virus genome studies in burkitt's and non-burkitt's lymphomas in uganda.burkitt's lymphoma (bl) has been widely investigated and has attracted attention because of the possible etiologic role of the epstein-barr virus (ebv). to further determine the role of ebv in the causation of this tumor, we measured ebv-specific nuclear antigen (ebna) and ebv dna using immunofluorescence and nucleic acid hybridization techniques, respectively. of 34 bl biopsies, 27 tissues (79%) were ebna-positive, whereas none of the 25 non-bl biopsy tissues were ebna-positive. of 15 bl tumors ...1977192894
a solid-phase radioimmunoassay for epstein-barr virus-associated membrane antigen prepared from b95-8 cell culture supernatants.epstein-barr virus(ebv)-associated membrane antigen (ma) was concentrated from b95-8 cell culture media by precipitation with polyethylene glycol followed by chromatography on bio-gel a-50m. in a raji cell-binding assay, ma-positive material could only be found in the void volume of the column. after ultracentrifugation all antigenic activity appeared in the pellet, which suggested that ma was present in aggregates, presumably fragments of cellular membranes and/or virus envelopes. the ma-contai ...1977192896
activation of epstein-barr virus in hybrid cells.human-primate hybrid cell lines were established by fusion of african green monkey kidney cells (vero) with lymphoblastoid cells from patients with infectious mononucleosis (im)(imk101) and from burkitt's lymphoma culture (hr1k). both epstein-barr virus (ebv)-specific antigens and ebv particle-containing cells increased in the hybrid lines (imk1-1/vero,hr1k/vero). treatment of the hybrids with 5-bromodeoxyuridine induced more antigen-positive and more virus-containing cells. ebv could be activat ...1977192898
solubilization of the epstein-barr virus-determined nuclear antigen and its characterization as a dna-binding protein.the eptstein-barr virus (ebv)-determined nuclear antigen (ebna) was solubilized from isolate nuclei of two ebv-transformed cell lines- raji and aw-ramos, by high-salt treatment. its dna-binding properties were studied by dna-cellulose chromatography and a 51cr release complement fixation assay. ebna binds to both double-stranded and single-stranded calf thymus dna, showing a higher affinity to double-stranded dna. there was no detectable difference in the dna binding of ebna prepared from raji a ...1977192908
[epstein-barr virus (ebv) in lymphoid cells--a human tumor virus?]. 1977192982
immune surveillance--a powerful mechanism with a limited range.there is excellent evidence for the belief that immune surveillance mechanisms prevent the outgrowth of potentially neoplastic cells induced by horizontally transmitted, ubiquitous, potentially oncogenic viruses, indigenous to natural populations. polyoma virus in mice, marek's disease in the chicken, herpesvirus saimiri in the squirrel monkey, and the epstein-barr virus in man are examples. there is much less evidence for immune surveillance against chemically induced tumors. it is argued that ...1976193016
mechanisms of escape from immune surveillance.the escape from immune rejection is, like the development of drug resistance in microorganisms, a multi-pathway process. selection favors the phenotype, i.e., the cell that can grow in spite of the immune rejection process, not the underlying mechanism. experimental evidence documents the roles of host immunosuppression (genetic or environmental), immunoresistance at the cellular level, "sneaking through" (i.e., growth of a tumor to irreversible size prior to the mobilization of an appropriate i ...1976193018
polyclonal ig production after epstein-barr virus infection of human lymphocytes in vitro. 1977193041
[malignant nasopharyngeal tumors at an early age]. 1977193058
neoplasms of the nasopharynx in children.neoplasms of the nasopharynx are rare in children, but they threaten the child's life when they do occur. the nasopharynx tends to harbor dysontogenetic neoplasms. after classification into benign and malignant groups, nasopharyngeal neoplasms in children can be further characterized according to the age of the patients in which the clinical manifestations usually appear. dermoids and teratomas are the most frequently encountered neoplasms of the nasopharynx in infants and may produce airway obs ...1977193080
[current problems posed by viruses of the herpes group]. 1977193083
epstein-barr virus dna synthesized in superinfected raji cells. 1977193261
[antibodies to epstein-barr virus in the sera of children with different neoplasms].the presence of antibody to virus capsid antigen (vca) of epstein-barr virus (ebv) was determined in sera from children with various forms of neoplasia by the indirect immunofluorescence procedure of henle. eighty-one sera from children with wilms tumor, teratoblastoma, reticulosarcoma, neuroblastoma, soft tissue sarcoma, as well as from children with benign tumors were examined. the controls included sera from normal children of the same ages. the test cells synthesizing vca were suspension cul ...1976193303
early acquisition of cytomegalovirus and epstein-barr virus antibody in several isolated melanesian populations.significant differences among diverse human populations have been found in the seroepidemiology of cytomegalovirus (cmv) and epstein-barr virus (ebv). the present report documents a very high rate of early acquisition of antibody to cmv and ebv among three remote populations living in the eastern highlands of papua new guinea, the solomon islands, and the new hebrides, respectively. these three genetically distinct populations, living in widely different ecologies and social settings, each had t ...1977193397
herpesvirus group antibodies in children with hodgkin's disease.during the period of three years ((1972-1974), serum samples from 60 patients (children and adolescents) with lympho-hematopoietic system diseases were examined for antibodies to all four human herpesviruses. among these were 26 active hodgkin's disease (ahd) patients and 6 hd patients with a minimum five years' remission. simultaneously matched controls (age, sex) of ahd patients were examined. antibody levels against the viral capsid antigen of epstein-barr virus (ebv/vca) in ahd patients were ...1977193463
possible transformation of nasopharyngeal epithelial cells in culture with epstein-barr virus from b95-8 cells.explants of fresh biopsy specimens from non-neoplastic nasopharyngeal (np) mucosa, nasopharyngeal carcinoma (npc), other tumours (ot) of the head and neck and freshly removed tonsils were treated with an epstein-barr virus (ebv) preparation from b95-8 cells and cultured. the mainly epitheloid outgrowths from these infected explants were then compared with those from their respective uninfected controls at 14 days. growth stimulation occurred with a significantly higher frequency, and the degree ...1977193548
cell surface markers on epithelial-burkitt hybrid cells superinfected with epstein-barr virus.attempts were made to superinfect two epithelial-burkitt hybrid cell lines, designated d98/hr-1 and d98/raji, with epstein-barr virus (ebv) and to investigate the expression of some cell surfacr markers including histocompatibility antigens, and the presence of b-cell markers, such as receptors for the third complement component and for monkey red blood cells. successful superinfection of d98/hr-1 cells with ebv was made evident by the expression of early antigen and, to a lesser extent, virus c ...1977193641
smooth muscle antibody in burkitt's lymphoma and in nasopharyngeal carcinoma.smooth muscle antibodies (sma) with specificity for actin, were found with a higher frequency in sera from burkitt's lymphoma (bl) and nasopharyngeal carcinoma (npc) patients than in sera from matched controls. no correlation could be found between sma and anti-epstein-barr virus (ebv) antibody titres. there was no parallelism, in individual sera, between the finding of sma and the occurrence of cold lymphocytotoxins, aother antibody activity found with an abnormally high frequency among bl and ...1977193662
inhibition of the in vitro outgrowth of epstein-barr virus-transformed lymphocytes by thymus-dependent lymphocytes from infectious mononucleosis patients.known numbers of thymus-dependent (t) lymphocytes, obtained by positive selection from the blood of acute infectious mononucleosis (im) patients and from control donors, were added to target cultures of foetal mononuclear cells within 0-7 days of exposure of the target cells to one of a range of doses of epstein-barr (eb) virus. the subsequent outgrowth of virus-transformed foetal cells was markedly inhibited by the presence in the cultures of im-derived t cells, whilst similar numbers of t cell ...1977193663
neutralizing ebv-specific iga in throat washings of nasopharyngeal carcinoma (npc) patients.throat washings from 26 nasopharyngeal carcinoma (npc) patients from hong kong and tunisia were studied for the presence of transforming ebv. only six (23%) were found positive which led to the hypothesis of a neutralizing factor in such salivas. the search for ebv-specific antibodies showed that npc saliva contained neutralizing vca and ea iga (54 and 27% respectively) and vca and ea igg (73 and 54% respectively). both transforming and non-transforming throat washings contained virus particles ...1977193801
epstein-barr virus-specific rna. ii. analysis of polyadenylated viral rna in restringent, abortive, and prooductive infections.the complexity and abundance of epstein-barr (ebv)-specific rna in cell cultures restringently, abortively, and productively infected with ebv has been analyed by hybridization of the infected cell rna with purified viral dna. the data indicate the following. (i) cultures containing productively infected cells contain viral rna encoded by at least 45% of ebv dna, and almost all of the species of viral rna are present in the polyadenylated and polyribosomal rna fractions. (ii) restringently infec ...1977194056
circular epstein-barr virus genomes of reduced size in a human lymphoid cell line of infectious mononucleosis origin.circular epstein-barr virus (ebv) dna molecules have been purified and characterized from a human lymphoid cell line derived from a case of heterophile antibody-positive, blood transfusion-induced infectious mononucleosis, 883l. the circular ebv dna in three cell lines obtained by transformation of human umbilical cord blood leukocytes with a strain of ebv originally derived from 883l was also studied. as estimated from sedimentation velocity data and electron microscopy, the circular ebv dna mo ...1977194059
elevated epstein-barr antibodies in an infant with hepatitis. 1977194143
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