gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics.gastric cancer is traditionally divided into intestinal and diffuse histological subtypes, but recent molecular analyses have led to novel classification proposals based on genomic alterations. while the intestinal- and diffuse-type tumours are distinguishable from each other at the molecular level, intestinal-type tumours have more diverse molecular profile. the technology required for comprehensive molecular analysis is expensive and not applicable for routine clinical diagnostics. in this stu ...201729046940
[differential diagnosis of mediastinal and hilar lymphadenopathy with focus on occupational diseases].hilar and mediastinal lymphadenopathy may represent a diagnostic challenge in clinical practice. this article is intended to facilitate differential diagnosis by a systematic description of relevant pathologies, notably with occupational etiology. clinical findings of relevant diseases, i. e. of tuberculosis, chronic beryllium disease, sarcoidosis, lung cancer, malignant lymphoma, epstein-barr virus infection, and histoplasmosis are history, imaging and laboratory tests have import ...201729046010
new-onset diabetes after kidney transplantation: can the risk be modified by choosing immunosuppression regimen based on pretransplant viral serology?this study aimed to analyze adult kidney transplant recipients (ktrs) for the risk of new-onset diabetes after transplantation (nodat) associated with viral serologies and immunosuppression regimens [tacrolimus (tac) + mycophenolate (mpa), cyclosporine (csa) + mpa, sirolimus (srl) + mpa, srl + csa or srl +tac].201829045704
epstein-barr virus-positive mucocutaneous ulcer with a background of crohn's disease and waldenström macroglobulinaemia: a case report highlighting diagnostic pitfalls. 201729044604
polymerase chain reaction and goldmann-witmer coefficient to examine the role of epstein-barr virus in use polymerase chain reaction (pcr) and goldmann-witmer coefficient (gwc) calculation to search for evidence that epstein-barr virus (ebv) causes uveitis.201729039992
clinical outcomes of residual or recurrent nasopharyngeal carcinoma treated with endoscopic nasopharyngectomy plus chemoradiotherapy or with chemoradiotherapy alone: a retrospective study.local residual and recurrent nasopharyngeal carcinoma (npc) generally shows treatment failure after standard radiotherapy with or without concurrent chemotherapy. whether endoscopic nasopharyngectomy might provide an additional therapeutic advantage remains controversial. therefore, we retrospectively compared the clinical prognoses of patients with residual or recurrent npc treated with endoscopic nasopharyngectomy combined with chemoradiotherapy (crt) with those of patients treated with crt al ...201729038762
latent hiv-1 tar regulates 7sk-responsive p-tefb target genes and targets cellular immune responses in the absence of tat.the transactivating response element (tar) structure of the nascent hiv-1 transcript is critically involved in the recruitment of inactive positive transcription elongation factor b (p-tefb) to the promoter proximal paused rna polymerase ii. the viral transactivator tat is responsible for subsequent p-tefb activation in order to start efficient viral transcription elongation. in the absence of the viral transactivator of transcription (tat), e.g., during latency or in early stages of hiv transcr ...201729037489
oncogenic epstein-barr virus recruits nm23-h1 to regulate chromatin cancer progression, metastasis is a major cause of poor survival of patients and can be targeted for therapeutic interventions. the first discovered metastatic-suppressor nm23-h1 possesses nucleoside diphosphate kinase, histidine kinase, and dnase activity as a broad-spectrum enzyme. recent advances in cancer metastasis have opened new ways for the development of therapeutic molecular approaches. in this review, we provide a summary of the current understanding of nm23/ndpks in the context of ...201729035376
comparison of two automated instruments for epstein-barr virus serology in a large adult hospital and implementation of an epstein-barr virus nuclear antigen-based testing algorithm.serology remains the mainstay for diagnosis of epstein-barr virus (ebv) infection. this study compared two automated platforms (bioplex 2200 and architect i2000sr) to test three ebv serological markers: viral capsid antigen (vca) immunoglobulins of class m (igm), vca immunoglobulins of class g (igg) and ebv nuclear antigen-1 (ebna-1) igg. using sera from 65 patients at various stages of ebv disease, bioplex demonstrated near-perfect agreement for all ebv markers compared to a consensus reference ...201729034860
genome-wide analysis of epstein-barr virus identifies variants and genes associated with gastric carcinoma and population structure.epstein-barr virus is a ubiquitous virus and is associated with several human malignances, including the significant subset of gastric carcinoma, epstein-barr virus-associated gastric carcinoma. some epstein-barr virus-associated diseases are uniquely prevalent in populations with different geographic origins. however, the features of the disease and geographically associated epstein-barr virus genetic variation as well as the roles that the variation plays in carcinogenesis and evolution remain ...201729034771
the infectious basis of acpa-positive rheumatoid arthritis.rheumatoid arthritis (ra) is associated with hla-drb1 shared epitope (hla-drb1se) and anti-citrullinated protein autoantibodies (acpas). acpas precedes the onset of clinical and subclinical ra. there are strong data for three infectious agents as autoimmunity triggers in ra, namely porphyromonas gingivalis and aggregatibacter actinomycetemcomitans causes of periodontal disease (pd), and epstein-barr virus (ebv). p. gingivalis expresses arginine gingipains, that cleave proteins at the arginine re ...201729033912
torquetenovirus dynamics and immune marker properties in patients following allogeneic hematopoietic stem cell transplantation: a prospective longitudinal study.torquetenovirus (ttv) has been proposed as a marker of immune function in patients receiving immunosuppression after solid organ transplantation. this study aimed to define ttv plasma dynamics and investigate clinical associations in patients following allogeneic hematopoietic stem cell transplantation (hsct). this was a single-center prospective longitudinal study involving 50 consecutive patients treated with hsct between march 2015 and april 2016. ttv plasma dna levels were measured with quan ...201829032273
virus and host-specific differences in oral human herpesvirus shedding kinetics among ugandan women and children.human herpesviruses (hhv) establish lifelong latent infection and are transmitted primarily via shedding at mucosal surfaces. each hhv causes a unique spectrum of disease depending on the infected individual's age and immunity. we collected weekly oral swabs from young children and mothers in 32 ugandan households for a median of one year. we characterized kinetics of oral shedding during primary and chronic infection for each virus. cytomegalovirus (cmv), epstein-barr virus (ebv), and hhv-6 wer ...201729026166
setting the stage for 2018: how the changes in the american joint committee on cancer/union for international cancer control cancer staging manual eighth edition impact radiologists.the updated eighth edition of the cancer staging manual of the american joint committee on cancer will be implemented in january 2018. there are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. human papillomavirus-related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly b ...201729025723
the epstein-barr virus regulome in lymphoblastoid cells.epstein-barr virus (ebv) transforms b cells to continuously proliferating lymphoblastoid cell lines (lcls), which represent an experimental model for ebv-associated cancers. ebv nuclear antigens (ebnas) and lmp1 are ebv transcriptional regulators that are essential for lcl establishment, proliferation, and survival. starting with the 3d genome organization map of lcl, we constructed a comprehensive ebv regulome encompassing 1,992 viral/cellular genes and enhancers. approximately 30% of genes ess ...201729024646
de novo hepatocellular carcinoma post-multivisceral transplantation in a novo hepatocellular carcinoma (hcc) post-transplantation in patients without viral hepatitis is extremely rare, with only three reported adult cases in the english literature. here, we present a case of de novo hcc that developed in a 7-year-old female, who at 8 months of age received a liver, small bowel, spleen, and pancreas transplantation 6.5 years ago for gastroschisis and total parenteral nutrition (tpn)-related cirrhosis. the post-transplant course was complicated by epstein-barr virus ...201729024228
chronic active epstein-barr virus infection with cutaneous lymphoproliferation: haemophagocytosis in the skin and haemophagocytic syndrome. 201729024023
fdg-pet/ct findings of chronic active epstein-barr virus infection. 201729022747
systemic and terminal ileum mucosal immunity elicited by oral immunization with the ty21a typhoid vaccine in humans.systemic cellular immunity elicited by the ty21a oral typhoid vaccine has been extensively characterized. however, very limited data are available in humans regarding mucosal immunity at the site of infection (terminal ileum [ti]). here we investigated the host immunity elicited by ty21a immunization on terminal ileum-lamina propria mononuclear cells (lpmc) and peripheral blood in volunteers undergoing routine colonoscopy.201729022005
data supporting the functional role of eleven-nineteen lysine-rich leukemia 3 (ell3) in b cell lymphoma cell line cells.the data presented here are related to the research article entitled "selective expression of the transcription elongation factor ell3 in b cells prior to ell2 drives proliferation and survival" (alexander et al., 2017) [1]. the cited research article characterizes eleven-nineteen lysine-rich leukemia 3 (ell3) expression in the b cell compartment and functional dependence in b lymphoma cell lines. this data report describes the mrna expression pattern in a panel of cell lines representing the b ...201729022001
relapsing ebv encephalitis in a renal transplant solid organ transplant recipients, epstein-barr virus (ebv) can cause active central nervous system (cns) infection or malignant transformation of latently infected cells in the cns, known as post-transplant lymphoproliferative disease (ptld). reduction of t-cell immunosuppression is the cornerstone of management. the role of antivirals with in-vitro activity against herpesviruses in ebv-related cns syndromes is controversial, as they have no effect on latent virus. we report an unusual case ...201729021960
association between epstein-barr virus (ebv) and cervical carcinoma: a meta-analysis.human papillomavirus (hpv) has been implicated as a major factor in cervical carcinogenesis. however, many pieces of evidence gathered over the last two decades suggest epstein-barr virus (ebv) plays a secondary role in this process. the purpose of the present meta-analysis was to determine whether the presence of ebv infection increases the risk of cervical carcinoma. based on 25 articles, the analysis yielded a 33.44% overall pooled prevalence of ebv. the pooled prevalence was higher in patien ...201729021084
multiple evanescent white dot syndrome following acute epstein-barr virus investigate the association between multiple evanescent white dot syndrome (mewds) and epstein-barr (eb) virus infection.201729020489
kinetics of double-stranded dna viremia after allogeneic hematopoietic cell transplantation.improved understanding of double-stranded dna (dsdna) virus kinetics after hematopoietic cell transplantation (hct) would facilitate development of therapeutic strategies.201829020348
il-27-induced type 1 regulatory t-cells produce oxysterols that constrain il-10 production.the behaviors of lymphocytes, including cd4+ t helper cells, are controlled on many levels by internal metabolic properties. lipid metabolites have recently been ascribed a novel function as immune response modulators and perturbation of steroids pathways modulates inflammation and potentially promotes a variety of diseases. however, the impact of lipid metabolism on autoimmune disease development and lymphocyte biology is still largely unraveled. in this line, oxysterols, oxidized forms of chol ...201728993775
a distinctive subgroup of oral ebv+ b-cell neoplasm with polymorphous features is potentially identical to ebv+ mucocutaneous ulcer.epstein-barr virus-positive mucocutaneous ulcer (ebvmcu) is a newly recognized provisional entity included in mature b-cell neoplasm in the latest 2016 world health organization classification. it has a self-limited growth potential with a high predilection for oral cavities and occurs in age-related or iatrogenic immunodeficiency with indolent clinical courses. however, it shares histological features with ebv-positive diffuse large b-cell lymphoma (dlbcl), and this often leads to diagnostic ch ...201728993276
[the epstein-barr virus and the centriole: new tricks from an old dog]. 201728990548
the oncogenic role of epstein-barr virus-encoded micrornas in epstein-barr virus-associated gastric carcinoma.epstein-barr virus (ebv) infection is detected in various epithelial malignancies, such as nasopharyngeal carcinoma (npc) and gastric cancer (gc). ebv comprises some unique molecular features and encodes viral genes and micrornas (mirnas) by its own dna sequence. ebv genes are required to maintain latency and contribute to oncogenic property. mirnas encoded by ebv have been shown to contribute to initiation and progression of ebv-related malignancies. by a number of genomic profiling studies, so ...201828990284
severe infectious mononucleosis in immunocompetent determine the risk factors for severe infectious mononucleosis (im) occurrence in immunocompetent adults.201728987291
a study of epstein-barr virus infection in the chinese tree shrew(tupaia belangeri chinensis).epstein-barr virus (ebv) is closely associated with many human diseases, including a variety of deadly human malignant tumours. however, due to the lack of ideal animal models,the biological characteristics of ebv, particularly its function in tumourigenesis, have not been determined. chinese tree shrews (tupaia belangeri chinensis), which are similar to primates, have been used to establish a variety of animal models and have recently received much attention. here, we established tree shrews as ...201728985762
viral infections in solid organ transplant recipients: novel updates and a review of the summarize new discoveries in viral pathogenesis and novel therapeutic and prophylactic strategies in organ transplant recipients.201728984642
ebv-positive post-transplant lymphoproliferative disorder presenting as primary diffuse large b-cell lymphoma of the central nervous system.primary central nervous system post-transplant lymphoproliferative disorder (pcns-ptld) is a rare complication with inferior survival outcomes in solid organ transplant patients. it represents approximately 7-15% of all ptld patients. because of the rarity of this disease, the diagnosis of pcns-ptld is often challenging, and the optimal therapy has not been established. we report a case of a renal transplant patient who initially presented with acute altered neurological function, an enhancing m ...201728984115
viral causes of lymphoma: the history of epstein-barr virus and human t-lymphotropic virus 1964, epstein, barr, and achong published a report outlining their discovery of viral particles in lymphoblasts isolated from a patient with burkitt lymphoma. the epstein-barr virus (ebv) was the first human cancer virus to be described, and its discovery paved the way for further investigations into the oncogenic potential of viruses. in the decades following the discovery of ebv, multinational research efforts led to the discovery of further viral causes of various human cancers. lymphomas ...201728983187
multivariate analysis of prognosis for patients with natural killer/t cell lymphoma-associated hemophagocytic lymphohistiocytosis.a major cause of hemophagocytic lymphohistiocytosis (hlh) is malignant neoplasms of the blood system, among which nk/t cell lymphoma is one of the most common risk factors. patients with nk/t cell lymphoma hemophagocytic lymphohistiocytosis (nk/t-lahs) have a worse prognosis and higher mortality. we aimed to explore the factors that affect the prognosis of nk/t-lahs.201728982299
de novo unclassifiable cd20-negative diffuse large b-cell lymphoma: a diagnostic and therapeutic challenge.cd20-negative diffuse large b-cell lymphomas (dlbcls) constitute a rare and heterogeneous group of aggressive lymphomas. known well-documented variants include plasmablastic lymphomas, primary effusion lymphomas, anaplastic kinase-positive large b-cell lymphomas, and large b-cell lymphomas arising in human herpesvirus 8 (hhv8)-associated multicentric castleman disease. they impose diagnostic challenges for pathologists and therapeutic confrontations for clinicians. cd20 loss in b-cell lymphomas ...201728982264
[the role of persistent viral infections with herpes viridae and papilloma viridae associated with chronic inflammatory pathology of the oropharynx].the high prevalence of chronic inflammatory oropharyngeal pathologies and a large variety of specific pathogenetic features of the persistent viral infections caused by the species of the families herpesviridae and papillomaviridae as etiological agents of the disease suggest the necessity of investigations with a view to evaluating the clinical significance of persistent viral infections with herpesviridae and papillomaviridae species in the patients presenting with chronic inflammatory orophar ...201728980591
[specific immunoglobulins g and m in blood serum in retinoblastoma and 'pseudoretinoblastoma'].perinatal inflammatory retinal diseases and intrauterine retinal maldevelopments are mistaken for retinoblastoma as often as in 8-16% of cases.201728980560
ly6chigh monocytes facilitate transport of murid herpesvirus 68 into inflamed joints of arthritic mice.viruses, particularly the epstein-barr virus (ebv) has long been suspected to exacerbate acute arthritic symptoms. however, the cell populations that contribute to import viruses into the inflamed tissues remain to be identified. in the present study, we have investigated the role of monocytes in the transport of murid herpesvirus 68 (mhv-68), a mouse virus closely related to ebv, using the serum transfer-induced arthritis (stia) model. we found compelling evidence that mhv-68 infection markedly ...201728980305
differentiated tumor immune microenvironment of epstein-barr virus-associated and negative gastric cancer: implication in prognosis and immunotherapy.epstein-barr virus-associated gastric cancer (ebvagc) has been proposed to be a distinct subtype with a specific immune microenvironment. here, we evaluated tumor-infiltrating t-cell subsets and the expression of programmed cell death protein 1 (pd-1) and programmed death-ligand 1 (pd-l1) in 571 gastric cancers (gcs). tissue microarrays were stained using eber in situ hybridization for ebv and using immunohistochemistry for cd4, cd8, foxp3, pd-1 and pd-l1. gcs were categorized into four types ba ...201728978018
combination of betulinic acid and chidamide synergistically inhibits epstein-barr virus replication through over-generation of reactive oxygen species.epstein-barr virus (ebv) has widely infected more than 90% of human populations. currently, there is no efficient way to remove the virus because the ebv carriers are usually in a latent stage that allows them to escape the immune system and common antiviral drugs. in the effort to develop an efficient strategy for the removal of the ebv virus, we have shown that betulinic acid (ba) slightly suppresses ebv replication through sod2 suppression with subsequent reactive oxygen species (ros) generat ...201728977893
autophagy proteins in viral exocytosis and anti-viral immune responses.abstract: autophagy-related (atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. this mini review discusses how these alternative atg functions support virus replication and viral antigen presentation on major histocompatibility (mhc) class i and ii molecules. a better u ...201728976939
tocilizumab for severe cytokine-release syndrome after haploidentical donor transplantation in a patient with refractory epstein-barr virus-positive diffuse large b-cell has been well documented that patients may develop cytokine-release syndrome (crs) following the administration of monoclonal antibodies, such as chimeric antigen receptor-modified t cell. cytokine-release syndrome is a common complication in patients who have received haploidentical donor allogeneic haematopoietic cell transplantation (haplo-hct). although severe crs after haplo-hct is a potentially life-threatening toxicity, a standard treatment has not been established. cytokine blockade w ...201728971493
autoimmune hepatitis: diagnostic dilemma when it is disguised as iron overload syndrome.elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. high transferrin saturation is not a common finding in above diseases except for iron overload syndrome. we encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and t ...201728970716
hemophagocytic lymphohistiocytosis masquerading as acute liver failure: a single center experience.hemophagocytic lymphohistiocytosis (hlh) is a potentially life-threatening disorder of extreme inflammation and unregulated immune response which require prompt recognition and early introduction of definitive therapy. hlh can present with wide range of hepatic dysfunction ranging from mild elevation of transaminases to liver failure. this study is carried out to describe the clinical and laboratory presentation of hlh.201728970704
lymphoepithelioma-like carcinoma of the esophagus: a rare tumor.lymphoepithelioma-like carcinoma of esophagus is a rare tumor with about 20 cases reported worldwide. it can involve the salivary gland, esophagus, stomach, thymus, thyroid, breast, lung, uterus, cervix, urinary bladder, and the skin. its association with epstein barr virus has been postulated. we report the case of a 45-year female who had been treated for hepatitis c and esophageal tuberculosis and recovered fully from these conditions. she presented with dysphagia of 2-3 month duration. endos ...201728969745
disseminated burkitt's lymphoma with a pancreatic mass in a hiv positive woman diagnosed by axillary lymph node biopsy.burkitt's lymphoma (bl) is a highly aggressive b cell lymphoma of non-hodgkin's type usually presenting in extranodal sites for endemic and sporadic types of the disease. like other non-hodgkin's lymphomas (nhl), hiv positive associated bl is associated with peripheral lymphadenopathy. we present a case of 22-year-old newly diagnosed hiv positive female patient who presented with generalized peripheral lymphadenopathy and obstructive jaundice. initial work up was suggestive of acute pancreatitis ...201728969187
pd-1 and pd-l1 co-expression predicts favorable prognosis in gastric cancer.while the prognosis of gastric cancer (gc) remains poor, pd-1 and pd-l1/l2 are promising prognostic biomarkers. we evaluated pd-1 and pd-l1/l2 expression in tumor cells (tcs) and tumor-infiltrating immune cells (tiics). we determined the helicobacter pylori (hp) and epstein-barr virus (ebv) infection status in a gc cohort (n=340), then analyzed the relationship between the expression of pd-1, pd-l1/l2 and gc prognosis. we found that pd-1, pd-l1, and pd-l2 mrna levels were up-regulated in gc tiss ...201728969052
human b cells fail to secrete type i interferons upon cytoplasmic dna exposure.most cells are believed to be capable of producing type i interferons (ifn i) as part of an innate immune response against, for instance, viral infections. in macrophages, ifn i is potently induced upon cytoplasmic exposure to foreign nucleic acids. infection of these cells with herpesviruses leads to triggering of the dna sensors interferon-inducible protein 16 (ifi16) and cyclic gmp-amp (cgamp) synthase (cgas). thereby, the stimulator of interferon genes (sting) and the downstream molecules ta ...201728968560
ebf1 binds to ebna2 and promotes the assembly of ebna2 chromatin complexes in b cells.epstein-barr virus (ebv) infection converts resting human b cells into permanently proliferating lymphoblastoid cell lines (lcls). the epstein-barr virus nuclear antigen 2 (ebna2) plays a key role in this process. it preferentially binds to b cell enhancers and establishes a specific viral and cellular gene expression program in lcls. the cellular dna binding factor cbf1/csl serves as a sequence specific chromatin anchor for ebna2. the ubiquitous expression of this highly conserved protein raise ...201728968461
epstein-barr virus-associated vesiculopapular eruption on the face of a patient with natural killer t cell lymphoma.unlike typical hydroa vacciniforme (hv), epstein-barr virus (ebv)-associated hv-like eruption is more variable in its clinical manifestations. in some patients, progression to lymphoma or leukemia has been reported, which are characterized by the t-cell immunophenotype. here, we report the first korean case of ebv-associated vesiculopapular eruption on the face of a patient with natural killer (nk)/t cell lymphoma. a 32-year-old korean man presented with a late adolescent-onset recurrent necroti ...201728966520
natural killer/t-cell lymphoma invading the orbit and globe.natural killer/t-cell lymphomas are extremely rare and carry high mortality rates. epidemiologically, these cancers tend to affect mainly asian and south american patients and are associated with epstein-barr virus seropositivity. this report details a 78-year-old vietnamese woman who presented initially with vitritis of unknown cause, but later developed proptosis and conjunctival involvement as her disease spread. biopsies of the orbit, ethmoid sinus, and conjunctiva were found to be significa ...201728966461
epstein-barr virus-positive diffuse large b-cell lymphoma.while the world health organization included epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) as a provisional entity of a lymphoma occurring in older individuals without any known immunodeficiency in 2008, it has since been recognized that this entity may occur in younger individuals. as a result, the 2016 revision has substituted the modifier "elderly" with "not otherwise specified" (nos). the nos highlights that there are more specific entities with neoplastic ebv-posit ...201728966459
epstein-barr virus lymphoproliferative disease after solid organ transplantation.epstein-barr virus (ebv) was the first identified human oncovirus and is also one of the most ubiquitous viral infections known with established infections in more than 90% of individuals by early adulthood. ebv establishes latency by controlling expression of the viral genome making it silent to immune surveillance. in immunocompetent individuals, up to 1% of circulating t cells are directed at maintaining control over ebv replication. in addition to being involved in oncogenesis of lymphoid an ...201728965834
recurrent scarring papulovesicular lesions on sun-exposed skin in a 22-year-old man.key teaching points.201728964535
the interaction between mitochondria and oncoviruses.mitochondria play important roles in multiple aspects of viral tumorigenesis. mitochondrial genomes contribute to the host's genetic background. after viruses enter the cell, they modulate mitochondrial function and thus alter bioenergetics and retrograde signaling pathways. at the same time, mitochondria also regulate and mediate viral oncogenesis. in this context, oncogenesis by oncoviruses like hepatitis b virus (hbv), hepatitis c virus (hcv), human papilloma virus (hpv), human immunodeficien ...201828962899
low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology.infection by common viruses has long been discussed in the aetiology of a number of autoimmune diseases, including rheumatoid arthritis (ra). however, studies investigating this hypothesis in ra show conflicting results. these studies often lack well-matched control populations, and many do not include data on autoantibodies, genetic risk factors and other environmental factors, which are known to contribute to disease only in subgroups of patients. in the present study, we have therefore examin ...201728962582
safety and efficacy of biologic agents for the management of inflammatory bowel disease after liver transplantation.primary sclerosing cholangitis (psc) frequently progresses to end-stage liver disease and cirrhosis, requiring liver transplantation. approximately 70% of patients with psc have concomitant inflammatory bowel disease (ibd) during their clinical course. after liver transplantation for psc, corticosteroids and other high-intensity immunosuppressants are initiated to keep ibd in remission. patients with ibd that is refractory to these agents may need to be managed with biologic therapies. biologic ...201728960437
coordinated repression of bim and puma by epstein-barr virus latent genes maintains the survival of burkitt lymphoma cells.while the association of epstein-barr virus (ebv) with burkitt lymphoma (bl) has long been recognised, the precise role of the virus in bl pathogenesis is not fully resolved. ebv can be lost spontaneously from some bl cell lines, and these ebv-loss lymphoma cells reportedly have a survival disadvantage. here we have generated an extensive panel of ebv-loss clones from multiple bl backgrounds and examined their phenotype comparing them to their isogenic ebv-positive counterparts. we report that, ...201828960205
epstein-barr virus fusion with epithelial cells triggered by gb is restricted by a gl glycosylation site.epstein-barr virus (ebv) entry into epithelial cells is mediated by the conserved core fusion machinery, composed of the fusogen gb and the receptor-binding complex gh/gl. the heterodimeric gh/gl complex binds to the ebv epithelial cell receptor or gp42, which binds to the b-cell receptor, triggering gb-mediated fusion of the virion envelope with cellular membranes. our previous study found that the gl glycosylation mutant n69l/s71v had an epithelial cell-specific hyperfusogenic phenotype. to st ...201728956769
epstein-barr virus-associated haemophagocytic lymphohistiocytosis presenting with acute sensorineural hearing loss: a case report and review of the literature.epstein-barr virus-associated haemophagocytic lymphohistiocytosis (ebv-hlh) is a life-threatening catastrophic and rarely seen complication of ebv infection especially in adults. while typical presentation of ebv infection is easily diagnosed as mononucleosis syndrome in teenagers and adults, some atypical clinical presentations may be challenged. we did not encounter any patient presenting with sudden sensorineural hearing loss associated with ebv infection in our english medical literature res ...201728956548
[clinical analysis of 7 patients with epstein-barr virus encephalitis after allogeneic hematopoietic stem cell transplantation].objective: to summarize the clinical features, treatment and prognosis of patients with epstein barr virus (ebv) encephalitis after allogeneic hematopoietic stem cell transplantation (allo-hsct) . methods: the clinical data of 7 patients with ebv encephalitis who had undergone allo-hsct in the first affiliated hospital of soochow university from january 2012 to december 2015 were reviewed. results: the incidence of ebv encephalitis was 0.70% (7/998) , and the median time was 63 (10-136) d after ...201728954347
depressive symptoms are associated with salivary shedding of epstein-barr virus in female adolescents: the role of sex differences.adolescent females have a higher prevalence of depression in comparison to their male peers - a disparity that has been increasing over the past decade. depression is of concern as it is associated with chronic disease and to immune dysregulation, which may be one mechanism linking depression to future pathology. this study examined the extent to which sex moderated the association between depressive symptoms and immune dysregulation during adolescence using epstein-barr virus (ebv) reactivation ...201728954244
resveratrol inhibits extranodal nk/t cell lymphoma through activation of dna damage response pathway.extranodal nk/t cell lymphoma (nktcl) is a highly aggressive non-hodgkin lymphoma with poor prognosis. resveratrol (rsv, 3,5,4'-trihydroxystilbene), a natural nontoxic phenolic compound found in the skin of grapes and some other spermatophytes, performs multiple bioactivities, such as antioxidant activity, anti-aging activity, reduction of cardiovascular disease risk and anticarcinogenic effect. here we report the anti-tumor effect of rsv in nktcl cell lines snt-8, snk-10 and snt-16.201728950914
the epstein-barr virus mir-bhrf1 micrornas regulate viral gene expression in cis.the epstein-barr virus (ebv) mir-bhrf1 microrna (mirna) cluster has been shown to facilitate b-cell transformation and promote the rapid growth of the resultant lymphoblastoid cell lines (lcls). however, we find that expression of physiological levels of the mir-bhrf1 mirnas in lcls transformed with a mir-bhrf1 null mutant (∆123) fails to increase their growth rate. we demonstrate that the pri-mir-bhrf1-2 and 1-3 stem-loops are present in the 3'utr of transcripts encoding ebna-lp and that excisi ...201728950226
concordance of immune checkpoints within tumor immune contexture and their prognostic significance in gastric cancer.checkpoint blockade therapy has emerged as a novel approach for cancer immunotherapy in several malignancies. however, patient prognosis and disease progression relevant to immune checkpoints in gastric tumor microenvironment are not defined. this study aims to investigate the expression and prognostic significance of immune checkpoints within gastric cancer. in the study, a cohort of 398 cancer tissues from stage i to iv gastric cancer patients were assessed for programmed cell death 1 ligand 1 ...201628949446
protein expression profiling in the hippocampus after focal cerebral ischemia injury in this study, we aimed to explore protein expression profiles in the hippocampus of rats after the induction of focal ischemia injury. forty sd male rats were randomly divided into 4 groups, with ten rats per group: the control, day 3, day 7, and day 14 after the ischemia injury surgery. focal cortical ischemia was induced in thirty rats by photothrombosis of the cortical microvessels. after surgery, the induction of ischemia was confirmed by the measurement of infarct size using 2,3,5-tripheny ...201728946568
expression of tfh markers and detection of rhoa p.g17v and idh2 p.r172k/s mutations in cutaneous localizations of angioimmunoblastic t-cell biopsies of 41 angioimmunoblastic t-cell lymphoma patients were retrospectively analyzed for the expression of follicular helper t-cell (tfh) markers, epstein-barr virus (ebv), and the presence of rhoa (p.g17v) and idh2 (p.r172k/s) mutations using allele-specific polymerase chain reaction. we categorized cases into 4 distinctive patterns: (1) low-density lymphocytic perivascular infiltrates (n=11), (2) dense perivascular infiltrates with atypical cells and occasional inflammatory cells (n=1 ...201728945625
risk of developing antiphospholipid antibodies following viral infection: a systematic review and meta-analysis.objective the objective of this paper is to conduct a systematic review and meta-analysis on the risk of developing elevated antiphospholipid (apl) antibodies and related thromboembolic and/or pregnancy events following a viral infection. method we searched medline, embase, web of science, pubmed epubs, and cochrane central register of controlled trials through june 2016. independent observational studies of elevated apl antibodies in patients with a viral infection compared with controls or pat ...201728945149
epstein-barr virus-driven promoter hypermethylated genes in gastric cancer. 201728943520
epstein-barr virus and cytomegalovirus mononucleosis: important causes of febrile illness in returned travellers.diagnosing the cause of fever in the returned traveller is challenging. efforts often focus on identifying 'exotic' pathogens. primary epstein-barr virus (ebv) and cytomegalovirus (cmv) infections cause clinical features that overlap with many exotic pathogens. the age-matched seroprevalence of both ebv and cmv is greater in tropical than temperate areas. we describe the clinical and laboratory features of returned travellers diagnosed with primary cmv and ebv syndromes.201728943374
lymphoma in the tofacitinib rheumatoid arthritis clinical development program.tofacitinib is an oral jak inhibitor for the treatment of rheumatoid arthritis (ra). we characterized lymphoma events in the tofacitinib ra clinical development program.201728941219
polymorphisms in homologous recombination repair genes and the risk and survival of breast cancer.immunoglobulin (ig)a antibody of epstein-barr virus (ebv) was found to associate with breast cancer (bc), whereas iga positivity was related to a series of genetic markers in the genes of homologous recombination repair system (hrrs). we assessed the associations of the polymorphisms in hrr genes with the risk and survival of bc.201728940489
study of association of epstein-barr virus in lymphomas by epstein-barr virus-encoded rna in situ hybridization: an indian perspective from a tertiary care cancer institute.the epstein-barr virus (ebv), also called human herpesvirus 4, is a virus of the herpes family. the ebv-associated lymphomas include burkitt lymphoma, classic hodgkin lymphoma (hl), lymphomas arising in immunocompromised individuals, peripheral t-cell lymphomas, angioimmunoblastic t-cell lymphoma, extranodal nasal-type natural killer/t-cell lymphoma, and other rare histotypes.201728937369
how viruses contribute to the pathogenesis of hemophagocytic lymphohistiocytosis.hemophagocytic lymphohistiocytosis (hlh) is a life-threatening, hyperinflammatory syndrome, characterized by the uncontrolled activation of macrophages and t cells, eliciting key symptoms such as persistent fever, hepatosplenomegaly, pancytopenia, hemophagocytosis, hyperferritinemia, and coagulopathy. viral infections are frequently implicated in the onset of active hlh episodes, both in primary, genetic hlh as in the secondary, acquired form. infections with herpesviruses such as epstein-barr v ...201728936212
the effect of perceived stress on epstein-barr virus antibody titers in appalachian ohio women.the appalachian population suffers a disparate burden of chronic stress leading to high perceived stress. the study aim was to determine the association between perceived stress and epstein-barr virus (ebv) antibody titers, along with the impact of perceived social support, appalachian self-identify, and health behaviors.201728934729
epstein-barr virus type 2 infects t cells in healthy kenyan children.the 2 strains of epstein-barr virus (ebv), ebv type 1 (ebv-1) and ebv-2, differ in latency genes, suggesting that they use distinct mechanisms to establish latency. we previously reported that ebv-2 infects t cells in vitro. in this study, we tested the possibility that ebv-2 infects t cells in vivo.201728934430
a multicenter study to evaluate the performance of high-throughput sequencing for virus detection.the capability of high-throughput sequencing (hts) for detection of known and unknown viruses makes it a powerful tool for broad microbial investigations, such as evaluation of novel cell substrates that may be used for the development of new biological products. however, like any new assay, regulatory applications of hts need method standardization. therefore, our three laboratories initiated a study to evaluate performance of hts for potential detection of viral adventitious agents by spiking ...201728932815
causal role of infectious agents in cancer: an overview.cancer is a complex group of diseases with multiple eventual causes. the underlying causes are not fully known. thus, learning more about the known causes of cancer is an important issue. moreover, among these factors, infection and its association to cancers is controversial. although, it seems that the genome instability of the cells can initiate cancer development. the purpose of this review was to present the role of infection in the development of cancer. infectious agents, such as hepatiti ...201728932365
guillain-barré-like axonal polyneuropathy associated with toscana virus infection: a case report.numerous cases of post-infectious guillain-barré syndrome (gbs) have been reported in the literature. toscana virus (tosv) is an arthropod-borne emerging pathogen in the mediterranean area.201728930847
associations of epstein-barr virus dna in pbmcs and the subtypes with breast cancer risk.objective: epstein-barr virus (ebv) has been found to be implicated in the development of breast cancer. the purpose of the present study was to identify the associations of ebv dna and the subtypes in peripheral blood mononuclear cells (pbmcs) with the risk of breast cancer. material and methods: a case-control study with 671 breast cancer cases and 859 age-matched controls was conducted in guangzhou, china. face-to-face interviews were performed and blood samples were collected immediately aft ...201728928885
primary lymphoepithelioma-like carcinoma of the lung: an unusual cancer and clinical outcomes of 14 patients.advanced lung cancer is considered to exhibit a poor prognosis; however, the pulmonary lymphoepithelioma-like carcinoma (lelc), a rare subtype of non-small cell lung cancer (nsclc), exhibits an improved prognosis, compared with non-lelc. the present study aimed at investigating the clinical manifestation, imaging characteristics, pathology, tumor markers, treatment and prognosis of primary lelc of the lung. a total of 14 patients with pulmonary lelc were confirmed by surgery and pathology. clini ...201728928848
cellular therapy for multiple pathogen infections after hematopoietic stem cell transplant.hematopoietic stem cell transplantation (hsct) represents the only crative treatment option for many hematological conditions but results in a profound t-cell deficiency in the post-hsct period. infections account for a significant proportion of non-relapse morbidity and mortality, and infections with multiple organisms either simultaneously or at different times after transplant are common. adoptive cellular therapy (act) with prophylactic or therapeutic infusion of donor derived or third-party ...201728927824
t cell therapies for human polyomavirus diseases.rapid restoration of virus-specific t immunity via adoptive transfer of ex vivo generated t cells has been proven as a powerful therapy for patients with advanced cancers and refractory viral infections such as cytomegalovirus (cmv) and epstein-barr virus (ebv). bk virus (bkv), john cunningham virus (jcv), and merkel cell carcinoma virus (mcv) are the members of the rapidly growing human polyomavirus (hpyv) family that commonly infects most healthy humans. these viruses have a clearly establishe ...201728927823
impact of monotherapy on hiv-1 reservoir, immune activation, and co-infection with epstein-barr virus.although monotherapy (mart) effectiveness in maintaining viral suppression and cd4 cell count has been extensively examined in hiv-1-infected patients, its impact on hiv-1 reservoir, immune activation, microbial translocation and co-infection with epstein-barr virus (ebv) is unclear.201728926641
no evidence for the presence of epstein-barr virus in squamous cell carcinoma of the mobile tongue.squamous cell carcinoma of the head and neck (scchn) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. within the oral cavity, the mobile tongue is the most common site for tumour development. the incidence of tongue squamous cell carcinoma (tscc) is increasing in younger people, which has been suggested to associate with a viral aetiology. two common human oncogenic viruses, human papillom ...201728926591
role of viruses in gastrointestinal cancer.gastrointestinal cancers are a global public health problem, which represent a vast majority of all cancer-caused deaths in both men and women. on the other hand, viral pathogens have been long implicated as etiological factors in the onset of certain human cancers, including gastrointestinal tumors. in this regard, human papilloma virus (hpv), epstein-barr virus (ebv), and john cunningham virus (jcv) have been more strongly suggested to be involved in gastrointestinal carcinogenesis; so that, t ...201728926109
pleuritic chest pain: sorting through the differential diagnosis.pleuritic chest pain is characterized by sudden and intense sharp, stabbing, or burning pain in the chest when inhaling and exhaling. pulmonary embolism is the most common serious cause, found in 5% to 21% of patients who present to an emergency department with pleuritic chest pain. a validated clinical decision rule for pulmonary embolism should be employed to guide the use of additional tests such as d-dimer assays, ventilation-perfusion scans, or computed tomography angiography. myocardial in ...201728925655
facial nerve palsy secondary to epstein-barr virus infection of the middle ear in pediatric population may be more common than we think.facial nerve palsy is a rare complication of acute otitis media (aom). the general understanding is that this complication has a bacterial cause although bacteria can be isolated from the middle ear only in approximately two-thirds of cases of aom. detection of viral agents from specimens obtained during myringotomy in patients with aom suggests a possible role of viruses in the etiology of this disease.201728924860
development of epstein-barr virus-related primary diffuse large b-cell lymphoma of the central nervous system in a patient with peripheral t-cell lymphoma, not otherwise specified after mogamulizumab treatment.mogamulizumab is a defucosylated humanized anti-cc chemokine receptor type 4 (ccr4) antibody that exerts an anti-tumor immune effect against various tumors through a suppressive effect on regulatory t-cells. we herein report a patient with peripheral t-cell lymphoma who developed epstein-barr virus (ebv)-related primary diffuse large b-cell lymphoma of the central nervous system (cns dlbcl) after mogamulizumab therapy. our experience should alert physicians to the possibility of the development ...201728924126
effects of deoxynivalenol- and zearalenone-contaminated feed on the gene expression profiles in the kidneys of piglets.fusarium mycotoxins deoxynivalenol (don) and zearalenone (zen), common contaminants in the feed of farm animals, cause immune function impairment and organ inflammation. consequently, the main objective of this study was to elucidate don and zen effects on the mrna expression of pro-inflammatory cytokines and other immune related genes in the kidneys of piglets.201828920417
swollen lymph nodes may not be clinical manifestations of chronic myeloid leukemia: case report and revision of literature.we present here the case of a 33-year-old chinese female patient with synchronous double primary malignant tumors (chronic myeloid leukemia [cml] and classic hodgkin lymphoma). this patient was admitted to our hospital because of bilateral cervical lymph node enlargement and recurrent fever for 2 weeks. the complete blood cell count revealed white blood cell counts of 18.2×109/l, hemoglobin of 9.6 g/dl, and platelet counts of 1,547×109/l. chromosome karyotype analysis demonstrated that t(9;22)(q ...201728919770
progesterone analogues reduce plasma epstein-barr virus dna load and improve pain control in recurrent/metastatic nasopharyngeal carcinoma patients under supportive care.progesterone analogues, such as megestrol acetate (ma) and medroxyprogesterone (mpa), have been used for the palliative care of cancer cachexia for decades and have proven to increase body weight and improve quality of life and performance status. the objective of this study was to determine the effect of progesterone analogue use on quality of life in terms of pain control, performance status, body weight gain, and epstein-barr virus (ebv) dna load in recurrent/metastatic nasopharyngeal carcino ...201728918909
detecting the genetic link between alzheimer's disease and obesity using bioinformatics analysis of gwas data.alzheimer's disease (ad) represents the major form of dementia in the elderly. in recent years, accumulating evidence indicate that obesity may act as a risk factor for ad, while the genetic link between the two conditions remains unclear. this bioinformatics analysis aimed to detect the genetic link between ad and obesity on single nucleotide polymorphisms (snps), gene, and pathway levels based on genome-wide association studies data. a total of 31 snps were found to be shared by ad and obesity ...201728915562
transplantation of solid organ recipients shedding epstein-barr virus dna pre-transplant: a prospective study.epstein-barr virus (ebv) poses a significant threat to patient and graft survival post-transplant. we hypothesized that recipients who shed ebv at transplant had less immunologic control of the virus and hence were more likely to have active ebv infection and disease post-transplant. to test this hypothesis, we conducted a 5-year prospective study in primary solid organ transplant recipients. we measured ebv dna in oral washes and blood samples by quantitative pcr before transplant and periodica ...201728915342
a yeast model for the mechanism of the epstein-barr virus immune evasion identifies a new therapeutic target to interfere with the virus stealthiness.the oncogenic epstein-barr virus (ebv) evades the immune system but has an achilles heel: its genome maintenance protein ebna1. indeed, ebna1 is essential for viral genome replication and maintenance but also highly antigenic. hence, ebv evolved a system in which the glycine-alanine repeat (gar) of ebna1 limits the translation of its own mrna at a minimal level to ensure its essential function thereby, at the same time, minimizing immune recognition. defining intervention points where to interfe ...201728913345
beyond first-line non-anthracycline-based chemotherapy for extranodal nk/t-cell lymphoma: clinical outcome and current perspectives on salvage therapy for patients after first relapse and progression of disease.current standard treatment, including non-anthracycline-based chemotherapy and optimal combining of radiotherapy, has dramatically improved outcomes of patients with extranodal natural killer/t-cell lymphoma (enktl) during the last decade. this study was conducted to investigate the clinical outcome of enktl patients with relapsed or progressive disease after initial current standard therapy.201728911074
[correlation analysis of the epstein-barr virus recruited regulatory t cells in nasopharyngeal carcinoma of immune escape].objective: to investigate the relation of epstein-barr virus (ebv)-induced immune escape to regulatory t cells(treg) in nasopharyngeal carcinoma(npc). methods: we recruited 83 patients who were pathologically diagnozed as nasopharyngeal carcinoma and treated in nanfang hospital from january to september 2016. cd4(+) cd25(+) foxp3(+) treg in peripheral blood was examined by flow cytometry and the level of ebv dna in the blood was detected by quantitative real-time polymerase chain reaction(qrt-pc ...201728910895
[progress in molecular mechanism of epstein-barr virus driving cell cycle and promoting oncogenesis]. 201728910884
chromatin reorganisation in epstein-barr virus-infected cells and its role in cancer development.the oncogenic epstein-barr virus (ebv) growth transforms b cells and drives lymphoma and carcinoma development. the virus encodes four key transcription factors (ebna2, ebna3a, ebna3b and ebna3c) that hijack host cell factors to bind gene control elements and reprogramme infected b cells. these viral factors predominantly target long-range enhancers to alter the expression of host cell genes that control b cell growth and survival and facilitate virus persistence. enhancer and super-enhancer bin ...201728910751
epstein barr virus latent membrane protein-1 enhances dendritic cell therapy lymph node migration, activation, and il-12 secretion.dendritic cells (dc) are a promising cell type for cancer vaccines due to their high immunostimulatory capacity. however, improper maturation of dc prior to treatment may account for the limited efficacy of dc vaccine clinical trials. latent membrane protein-1 (lmp1) of epstein-barr virus was examined for its ability to mature and activate dc as a gene-based molecular adjuvant for dc vaccines. dc were transduced with an adenovirus 5 vector (ad5) expressing lmp1 under the control of a tet-inducib ...201728910387
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