burkitt lymphoma and cavernous sinus syndrome with breast uptake on 18f-fdg-pet/ct: a case report.burkitt lymphoma (bl) is a type of non-hodgkin lymphoma that arises in the b-cells. cavernous sinus involvement is rare, especially in adults. here we report an unusual case of a 30-year-old hiv-positive woman with bl and cavernous sinus syndrome who also had intense bilateral breast uptake, related to menstrual cycle. fluorine-18 2-fluoro-2-deoxyglucose (18f-fdg) positron emission tomography/computed tomography (pet/ct) has been found to be useful in the management of bl.201729145302
target-induced proximity ligation triggers recombinase polymerase amplification and transcription-mediated amplification to detect tumor-derived exosomes in nasopharyngeal carcinoma with high sensitivity.tumor-derived exosomes (texs) are extracellular vesicles that are continuously released into the blood by tumor cells and carry specific surface markers of the original tumor cells. substantial evidence has implicated texs as attractive diagnostic markers for cancer. however, the detection of texs in blood at an early tumor stage is challenging due to their very low concentration. here, we established a method called pla-rpa-tma assay that allows texs to be detected with high sensitivity and spe ...201829145073
epstein-barr virus hijacks dna damage response transducers to orchestrate its life cycle.the epstein-barr virus (ebv) is a ubiquitous virus that infects most of the human population. ebv infection is associated with multiple human cancers, including burkitt's lymphoma, hodgkin's lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal carcinoma. intensive research has shown that ebv triggers a dna damage response (ddr) during primary infection and lytic reactivation. the ebv-encoded viral proteins have been implicated in deregulating ...201729144413
oncogenic spiral by infectious pathogens: cooperation of multiple factors in cancer development.chronic infection is one of the major causes of cancer, and there are several mechanisms for infection-mediated oncogenesis. some pathogens encode gene products that behave like oncogenic factors, hijacking cellular pathways to promote the survival and proliferation of infected cells in vivo. some of these viral oncoproteins trigger a cellular damage defense response leading to senescence; however, other viral factors hinder this suppressive effect, suggesting that cooperation of those viral fac ...201829143406
association of dna repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review.dna repair mechanisms allow maintain genomic stability and proper functioning within the cells. any aberrations may cause an increased risk of many diseases such as cancer. the most crucial risk factors for head and neck squamous cell carcinoma are behavioral factors, predominantly chronic exposure to tobacco, alcohol addiction, and infection with human papillomavirus or epstein-barr virus. these agents can induce dna damage; therefore, cells must activate appropriate mechanisms in order to func ...201729143133
correction to: abstracts : 29th european congress of poster sessions, the first-author name was missing from the authorship group originally listed for abstract ps-13-001 (page s176), entitled "gastric carcinoma with lymphoid stroma: analysis of microsatellite instability and epstein-barr virus status". the correct authorship group is shown above.201729143111
clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in determine the prevalence of epstein-barr virus (ebv)-associated gastric carcinomas in the north region of portugal and to study its clinicopathological characteristics.201729142476
the epstein-barr virus episome maneuvers between nuclear chromatin compartments during reactivation.the human genome is structurally organized in three-dimensional space to facilitate functional partitioning of transcription. we learned that the latent episome of the human epstein-barr virus (ebv) preferentially associates with gene-poor chromosomes and avoids gene-rich chromosomes. kaposi's sarcoma-associated herpesvirus behaves similarly, but human papillomavirus does not. contacts localize on the ebv side to orip, the latent origin of replication. this genetic element, and the ebna1 protein ...201729142137
epstein-barr virus protein eb2 stimulates translation initiation of mrnas through direct interactions with both poly(a)-binding protein and eukaryotic initiation factor 4g.epstein-barr virus (ebv) expresses several mrnas produced from intronless genes that could potentially be unfavorably translated compared to cellular spliced mrnas. to overcome this situation, the virus encodes an rna-binding protein (rbp) called eb2, which was previously found to both facilitate the export of nuclear mrnas and increase their translational yield. here, we show that eb2 binds both nuclear and cytoplasmic cap-binding complexes (cbc and eukaryotic initiation factor 4f [eif4f], resp ...201829142127
epstein-barr virus-positive mucocutaneous ulcer in a patient with polycythemia vera treated with oral hydroxyurea. 201729139148
correction for ansari et al., "constitutive interferon-inducible protein 16-inflammasome activation during epstein-barr virus latency i, ii, and iii in b and epithelial cells". 201729138330
programmed death ligand-1 and met co-expression is a poor prognostic factor in gastric cancers after resection.programmed death-ligand 1 (pd-l1) plays an essential protein for immune evasion, contributing to tumor development and progression. recent studies have reported met as an upregulator for pd-l1 overexpression through an oncogenic pathway. however, an association between pd-l1 expression with met has not been reported in gastric cancer.the prognostic significance of pd-l1 and its association with epstein-barr virus (ebv), microsatellite instability (msi), and mucin phenotype remain controversial. ...201729137273
ebv and apoptosis: the viral master regulator of cell fate?epstein-barr virus (ebv) was first discovered in cells from a patient with burkitt lymphoma (bl), and is now known to be a contributory factor in 1-2% of all cancers, for which there are as yet, no ebv-targeted therapies available. like other herpesviruses, ebv adopts a persistent latent infection in vivo and only rarely reactivates into replicative lytic cycle. although latency is associated with restricted patterns of gene expression, genes are never expressed in isolation; always in groups. h ...201729137176
[the prognostic significance of plasma epstein-barr virus dna in patients with diffuse large b cell lymphoma].to retrospectively analyze the prognostic significance of plasma epstein-barr virus (ebv) dna in 122 patients with diffuse large b cell lymphoma (dlbcl). plasma ebv dna positivity was related to advanced disease stage (p=0.030), b symptoms (p=0.004) and elevated serum lactic dehydrogenase (ldh) (p=0.001). furthermore, univariate analysis indicated that plasma ebv dna level was associated with worse overall survival (os) (hr=0.223, 95%ci 0.096-0.518, p<0.001) and worse progression free survival ( ...201729136714
unsuspected lymphomatoid granulomatosis in a patient with antisynthetase syndrome.clinical diagnosis of lymphomatoid granulomatosis (lyg) often is difficult, especially in patients with multiple comorbidities. we present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. computed tomography showed ground-glass opaciti ...201729136066
latent membrane protein 1 is a novel determinant of epstein-barr virus genome persistence and reactivation.epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus that persistently infects humans, with nearly 95% seropositivity in adults. infection in differentiating epithelia is permissive, but ebv-associated nasopharyngeal carcinoma (npc) tumors harbor a clonal and nonproductive latent infection. however, in explanted npc cultures and epithelial cell lines, episomal ebv genomes are frequently lost. the resulting unstable infection has hampered efforts to study the determinants of ebv persistence ...201729134204
interferon-γ-inducible protein 16 (ifi16) is required for the maintenance of epstein-barr virus latency.epstein-barr virus (ebv) exhibits both lytic and latent (lat. i, ii, and iii) phases in an infected individual. it's during the latent phase of ebv that all ebv-associated cancers, including burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. interferon-γ-inducible protein 16 (ifi16) is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading dna viruses. during latency, ifi16 remains in the nucleus, in part boun ...201729132393
a dramatic case of odynophagia.we report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. the severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ent, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). during this time, the patient received central parenteral nutrition ...201729128948
posttransplant lymphoproliferative disorder in solid organ and hematopoietic stem cell transplantation.posttransplant lymphoproliferative disorders (ptld) represent an immunosuppression-related lymphoid or plasmacytic proliferation that occur in the setting of solid organ transplant or allogeneic hematopoietic stem cell transplantation (hsct). ptld is a devastating consequence of hsct and solid organ transplantation with a high morbidity and mortality. most commonly, ptld is related to epstein-barr virus (ebv) infection, but an increasing number of non-ebv-related cases are occurring. initial the ...201729128025
gastric carcinomas with lymphoid stroma: categorization and comparison with solid-type colonic determine whether histologic features could help identify gastric carcinomas with lymphoid stroma associated with microsatellite instability (msi) (ie, "medullary carcinomas"), epstein-barr virus (ebv) infection (termed lymphoepithelioma-like carcinomas in other organ systems), or neither.201729126141
assessment of the combined effect of epstein-barr virus and plasmodium falciparum infections on endemic burkitt lymphoma using a multiplex serological approach.epstein-barr virus (ebv) is a necessary cause of endemic burkitt lymphoma (ebl), while the role of plasmodium falciparum in ebl remains uncertain. this study aimed to generate new hypotheses on the interplay between both infections in the development of ebl by investigating the igg and igm profiles against several ebv and p. falciparum antigens. serum samples collected in a childhood study in malawi (2005-2006) from 442 hiv-seronegative children (271 ebl cases and 171 controls) between 1.4 and 1 ...201729123514
encephalitis treatment - a case report with long-term follow-up of ebv pcr in cerebrospinal fluid.epstein-barr virus (ebv) has been found to cause infectious mononucleosis multiple times, but has been associated rarely with ebv encephalitis. also, whenever it is diagnosed, it is always treated symptomatically.201729123419
metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas.currently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed pcrs. with metagenomic deep sequencing (mds), an unbiased high-throughput sequencing approach, all pathogens as well as all mutations present in the host's genome can be detected in the same small amount of ocular fluid.201829122821
genetic predictors of response to systemic therapy in esophagogastric cancer.the incidence of esophagogastric cancer is rapidly rising, but only a minority of patients derive durable benefit from current therapies. chemotherapy as well as anti-her2 and pd-1 antibodies are standard treatments. to identify predictive biomarkers of drug sensitivity and mechanisms of resistance, we implemented prospective tumor sequencing of patients with metastatic esophagogastric cancer. there was no association between homologous recombination deficiency defects and response to platinum-b ...201829122777
programmed death-1 ligands pd-l1 and pd-l2 show distinctive and restricted patterns of expression in lymphoma subtypes.the success of immunotherapy using immune checkpoint blockade in solid tumors and in relapsed/refractory classical hodgkin lymphoma and chronic lymphocytic leukemia holds promise for targeted therapy in hematologic malignancies. because efficacy of immunomodulatory therapy is correlated with numbers of cells that express programmed death (pd-1) ligands, we evaluated the expression of pd-l1 and pd-l2 proteins using immunohistochemistry in more than 702 diagnostic lymphoma biopsies. in classical h ...201829122656
epstein-barr virus infection in multiple sclerosis patients.multiple sclerosis (ms) is the most common inflammatory autoimmune cns disease, with unknown etiology. we aimed to determine the coexistence of ms with antibodies to epstein-barr virus and its gene sequences (ebna1 and bhrf1). the study included 60 ms patients and 60 control subjects. serum samples were processed by elisa for detection of ebv antibodies, and latent ebv genes were determined by real time pcr in blood samples. while 18 (30%) ms cases had anti- ebv igm antibodies, all controls were ...201729120577
humanised mouse models for haematopoiesis and infectious diseases."humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity. they allowed the identification of key factors for the maintenance and function of normal and leukaemic human haematopoietic stem cells. these findings have been widely used to dissect the pathogenesis of multiple myeloid and lymphoid neoplasms, such as acute myeloid leukaemia and acute lymphoblastic leukaemia. furthermore, these models can serve as a stepping-stone to cli ...201729120027
computer-aided design of an epitope-based vaccine against epstein-barr virus.epstein-barr virus is a very common human virus that infects 90% of human adults. ebv replicates in epithelial and b cells and causes infectious mononucleosis. ebv infection is also linked to various cancers, including burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. currently, there are no effective drugs or vaccines to treat or prevent ebv infection. herein, we applied a computer-aided strategy to design a prophylactic epitope vaccine ensemb ...201729119120
pediatric pulmonary epstein-barr virus-positive diffuse large b-cell lymphoma: a case report and review of the literature.non-hodgkin's lymphoma (nhl) is a common malignancy of childhood; however, a lung primary presentation is an uncommon finding, as is finding an association with the epstein-barr virus (ebv). we report the case of a 23-month-old female who developed ebv-associated diffuse large b-cell lymphoma (dlbcl) that was initially thought to be pneumonia. extensive tissue necrosis, focal angioinvasion, and angiodestruction were observed. she was refractory to various therapy regimens, subsequently developed ...201729119031
c-myc represses transcription of epstein-barr virus latent membrane protein 1 early after primary b cell infection.recent evidence has shown that the epstein-barr virus (ebv) oncogene lmp1 is not expressed at high levels early after ebv infection of primary b cells, despite its being essential for the long-term outgrowth of immortalized lymphoblastoid cell lines (lcls). in this study, we found that expression of lmp1 increased 50-fold between 7 days postinfection and the lcl state. metabolic labeling of nascent transcribed mrna indicated that this was primarily a transcription-mediated event. ebna2, the key ...201829118124
elevated expression of ebv and tlrs in the brain is associated with rasmussen's encephalitis.rasmussen's encephalitis (re) is a rare pediatric neurological disorder, the etiology of which remains unclear. it has been speculated that the immunopathogenesis of re involves damage to neurons, which eventually leads to the occurrence of re. viral infection may be a critical factor in triggering re immunopathogenesis. in this study, we analyzed the expression of epstein-barr virus (ebv) antigens as well as of toll-like receptor 3 (tlr3), tlr9, and downstream adapter tirdomain-containing adapt ...201729116594
the regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.activation of specific sets of protein kinases by intracellular signal molecules has become more and more apparent in the past decade. phosphorylation, one of key posttranslational modification events, is activated by kinase or regulatory protein and is vital for controlling many physiological functions of eukaryotic cells such as cell proliferation, differentiation, malignant transformation, and signal transduction mediated by external stimuli. moreovers, the reversible modification of phosphor ...201729116588
prognostic value of plasma epstein-barr virus dna level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy.the value of epstein-barr virus (ebv) dna assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma (npc) presenting with different pretreatment plasma ebv dna levels remains unclear. in the present study, we aimed to evaluate the prognostic value of plasma ebv dna assay during posttreatment follow-up in the patients with npc who have undergone intensity-modulated radiotherapy.201729116021
identification of epstein-barr virus in the human placenta and its pathologic characteristics.epstein-barr virus (ebv), a common pathogen in humans, is suspected as the cause of multiple pregnancy-related pathologies including depression, preeclampsia, and stillbirth. moreover, transmission of ebv through the placenta has been reported. however, the focus of ebv infection within the placenta has remained unknown to date. in this study, we proved the expression of latent ebv genes in the endometrial glandular epithelial cells of the placenta and investigated the cytological characteristic ...201729115077
risk factors for post-transplant lymphoproliferative disorder after thymoglobulin-conditioned hematopoietic cell transplantation.epstein-barr virus (ebv)-induced post-transplant lymphoproliferative disorder (ptld) occurs frequently when rabbit antithymocyte globulin (atg) is used in hematopoietic cell transplant (hct) conditioning. we retrospectively studied 554 patients undergoing atg-conditioned myeloablative hct. strategies used to minimize mortality due to ptld were either therapy of biopsy-diagnosed ptld in the absence of ebv dnaemia monitoring (n = 266) or prompt therapy of presumed ptld (based on clinical/radiologi ...201829114932
diabetes and risk of kaposi's sarcoma: effects of high glucose on reactivation and infection of kaposi's sarcoma-associated herpesvirus.patients with diabetes are generally prone to pathogen infection and tumor progression. here, we investigated the potential association between diabetes and kaposi's sarcoma (ks), a tumor linked to infection with kaposi's sarcoma-associated herpesvirus (kshv). by using taiwan's national health insurance research database, we found that diabetes is statistically associated with increased risk of ks in a case-control study. since a high level of blood sugar is the hallmark of diabetes, we determin ...201729113328
toll-like receptor 9 polymorphism is associated with increased epstein-barr virus and cytomegalovirus acquisition in hiv-exposed infants.: polymorphisms in the toll-like receptor 9 1635 locus have been associated with hiv-1 acquisition and progression. cytomegalovirus (cmv) and epstein-barr virus (ebv) acquisition were compared between kenyan hiv-exposed infants by 1635 genotype. having one or more copies of the 1635a allele was associated with increased cmv acquisition in hiv-infected infants (42 vs. 11%, p = 0.03) and increased risk of ebv acquisition in hiv-exposed uninfected infants (hazard ratio = 4.2, p = 0.02) compared wit ...201829112074
b lymphoblastic leukemia/lymphoma with burkitt-like morphology and igh/myc rearrangement: report of 3 cases in adult patients.isolated myc rearrangement without other recurrent genetic abnormalities is rare in b lymphoblastic leukemia/lymphoma (b-all/lbl), with most cases reported in pediatric patients. we report 3 adult cases with lymphoblasts showing a precursor b cell immunophenotype, and isolated myc/igh translocation. all 3 cases occurred in male patients with initial presentation of diffuse lymphadenopathy. cases 1 and 2 had b-all with significantly increased lymphoblasts in peripheral blood and bone marrow. case ...201829112016
cancer therapy-associated lymphoproliferative disorders: an under-recognized type of immunodeficiency-associated lymphoproliferative disorder.we describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (lpd). there were 10 men and 7 women with a median age of 59 years (range, 36 to 83 y). the primary hematologic neoplasms included: 5 chronic lymphocytic leukemia/small lymphocytic lymphoma, 3 plasma cell myeloma, 2 acute monoblastic leukemia, and 1 case each of mixed-phenotype acute leukemia, chronic myeloid leukemia ...201829112013
epstein-barr virus brlf1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells.nasopharyngeal carcinoma (npc) is a serious health problem in china and southeast asia. relapse is the major cause of mortality, but mechanisms of relapse are mysterious. epstein-barr virus (ebv) reactivation and host genomic instability (gi) have correlated with npc development. previously, we reported that lytic early genes dnase and balf3 induce genetic alterations and progressive malignancy in npc cells, implying lytic proteins may be required for npc relapse. in this study, we show that imm ...201729108278
lymphoproliferative disorders with concurrent hhv8 and ebv infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder.lymphoproliferative disorders (lpd) characterised by human herpesvirus 8 (hhv8) and epstein-barr virus (ebv) infection are rare and two entities are included in the world health organisation classification: primary effusion lymphoma (pel) and germinotropic lpd. these two entities have very different clinicopathological presentations and prognosis. here we describe two cases of hhv8-positive, ebv-positive lymphoma with clinicopathological features that are not consistent with either pel or germin ...201729105119
pathogenic role of exosomes in epstein-barr virus (ebv)-associated cancers.exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, dna, messenger rnas (mrnas), and micrornas (mirnas). these nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. they contain various pathogenic factors whereby their adverse e ...201729104494
association between epstein barr virus and tongue squamous cell carcinoma in iranian patients.detection of epstein-barr virus in oral squamous cell carcinoma suggests its involvement in the carcinogenesis of oral cavity. but, there are few studies on the incidence of ebv genome in squamous cell carcinomas at specific locations in the oral cavity like tongue and with different tumor progression. in this study the presence of ebv genome in tongue squamous cell carcinoma (tscc) in iranian patients were investigated. accordingly, a total of 94 cases with tscc were firstly analyzed for the pr ...201729103768
single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among epstein-barr virus-associated junction protein beta 2 gene (gjb2) encodes one of connexins- connexin 26 (cx26), which mainly expressed in epithelial cells. cx26 is usually considered a channel to exchange information between cells, which plays a critical role in tumor cell proliferation.201729103018
a rare localised nasal cd30+ primary cutaneous t-cell lymphoma following liver transplantation.cutaneous t-cell post-transplant lymphoproliferative disorder (ptld) is a rare clinical presentation that can potentially turn aggressive in solid-organ transplant recipients if not detected and intervened on early. we encountered a rare case of rapidly worsening primary cutaneous cd30-positive, epstein-barr virus-negative anaplastic large cell lymphoma (alcl) of t-cell origin, manifesting as an isolated nasal tip lesion in a 71-year-old man 4 years after orthotopic liver transplantation. excisi ...201729103006
early disseminated lyme disease masquerading as mononucleosis: a case report.disseminated lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. in addition, the diagnosis can be further complicated by potentially false-positive test results.201729102094
how immunologic and genetic biomarkers impact hodgkin lymphoma classification, diagnosis, and management: a huge potential that yet needs to be exploited."ne è passata di acqua sotto i ponti." it has been a long time since the diagnosis of hodgkin lymphoma (hl) was exclusively based on the detection of typical reed-sternberg cells and the recognition of the characteristic morpho-histological background, as well as on the pathologist's skill. the discovery of immunologic, molecular genetic and virologic biomarkers has provided an objective contribution to the diagnosis and a scientific basis for a modern classification of hl. recent updates have c ...201729099538
hodgkin's lymphoma arising in a case of mycosis fungoides: an unusual association.mycosis fungoides is a cutaneous t-cell lymphoma with a high risk for developing secondary malignancies, especially b-cell lymphoproliferative disorders. about 40 cases of hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. we report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. multiple skin biopsies taken from the lesions on scalp and back confirmed the clinical diagnosis of mycosis fungoides ...201729098990
epstein-barr virus dna load kinetics analysis in allogeneic hematopoietic stem cell transplant recipients: is it of any clinical usefulness?there is a lack of clinical information regarding the usefulness of plasma epstein-barr virus (ebv) dna load kinetics analyses in the management of ebv infections in allogeneic hematopoietic stem cell transplantation (allo-hsct) recipients. namely, it remains unknown whether this type of analysis can help physicians to anticipate the development of high-level ebv dnaemia episodes requiring rituximab treatment or predict the risk of recurrent ebv dnaemia or post-transplant lymphoproliferative dis ...201729096390
age-related macular degeneration: a connection between human herpes virus-6a-induced cd46 downregulation and complement activation?viruses are able to interfere with the immune system by docking to receptors on host cells that are important for proper functioning of the immune system. a well-known example is the human immunodeficiency virus that uses cd4 cell surface molecules to enter host lymphocytes and thereby deleteriously destroying the helper cell population of the immune system. a more complicated mechanism is seen in multiple sclerosis (ms) where human herpes virus-6a (hhv-6a) infects astrocytes by docking to the c ...201729093709
analysis of epstein-barr virus genomes and expression profiles in gastric adenocarcinoma.epstein-barr virus (ebv) is a causative agent of a variety of lymphomas, nasopharyngeal carcinoma (npc), and ∼9% of gastric carcinomas (gcs). an important question is whether particular ebv variants are more oncogenic than others, but conclusions are currently hampered by the lack of sequenced ebv genomes. here, we contribute to this question by mining whole-genome sequences of 201 gcs to identify 13 ebv-positive gcs and by assembling 13 new ebv genome sequences, almost doubling the number of av ...201829093097
early epstein-barr virus genomic diversity and convergence toward the b95.8 genome in primary infection.over 90% of the world's population is persistently infected with epstein-barr virus. while ebv does not cause disease in most individuals, it is the common cause of acute infectious mononucleosis (aim) and has been associated with several cancers and autoimmune diseases, highlighting a need for a preventive vaccine. at present, very few primary, circulating ebv genomes have been sequenced directly from infected individuals. while low levels of diversity and low viral evolution rates have been pr ...201829093087
serologic and viral genome prevalence of hsv, ebv, and hcmv among healthy adults in wuhan, china.the worldwide infection rate of herpesvirus is high, but the detailed prevalence in china, especially the central area, remains unclear. in the present study, the prevalence of herpes simplex virus (hsv), epstein-barr virus (ebv), and human cytomegalovirus (hcmv) was investigated in 303 healthy adults in wuhan, a representative city in central china. viral-specific igg and igm titers were examined in the serum by chemiluminescent immunoassay, and the existence of viral genomic dna in blood cells ...201829091300
characterization of an anti-fetal achr monoclonal antibody isolated from a myasthenia gravis patient.we report here the sequence and functional characterization of a recombinantly expressed autoantibody (mab 131) previously isolated from a myasthenia gravis patient by immortalization of thymic b cells using epstein-barr virus and tlr9 activation. the antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the vhcdr2. the recombinant mab 131 is specific for the γ-subunit of the fetal achr to which it bound with sub-nanomolar apparent affinity, a ...201729089519
actionable gene-based classification toward precision medicine in gastric cancer.intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (gc). to realize precision medicine for gc patients, an actionable gene alteration-based molecular classification that directly associates gcs with targeted therapies is needed.201729089060
the conundrum of the epstein-barr virus-associated gastric carcinoma in the americas.epstein-barr virus-associated gastric carcinoma shows a higher prevalence in the americas than asia. we summarize all studies of epstein barr virus-associated gastric carcinoma in the americas, focusing on host characteristics, environmental associations and phylogeographic diversity of epstein-barr virus strains. in the americas, the prevalence of epstein barr virus-associated gastric carcinoma is 11.4%, more frequent in males and portray predominantly diffuse-type histology. ebers, ebnas, bart ...201729088902
irak4 is essential for tlr9-induced suppression of epstein-barr virus bzlf1 transcription in akata burkitt's lymphoma cells.burkitt's lymphoma (bl) is the most common childhood cancer in equatorial africa, and is endemic to areas where people are chronically co-infected with epstein-barr virus (ebv) and the malaria pathogen plasmodium falciparum. the contribution of these pathogens in the oncogenic process remains poorly understood. we showed earlier that the activation of toll-like receptor (tlr) 9 by hemozoin, a disposal product formed from the digestion of blood by p. falciparum, suppresses the lytic reactivation ...201729088270
adenovirus-associated acute appendicitis: an under-recognized relationship?acute appendicitis (aa) is one of the most common causes of a surgical abdomen worldwide, occurring most frequently in those age 10 to 29 years. adenovirus (adv) is a rare but reported cause of aa in children and a well-recognized cause of intussusception in infants and young children. annually, about 36,000 basic military trainees (bmts) undergo initial training at joint base san antonio lackland, texas. before reintroduction of the adv 4/7 vaccine in november 2011, one-third of bmts developed ...201729087922
epstein-barr virus positive diffuse large b-cell lymphoma presenting with vaginal sloughing and ulcerated skin nodule.malignant lymphomas presenting in the female genital tract are extremely rare. we report a case of epstein-barr virus associated diffuse large b-cell lymphoma of the genital tract and skin in a 60-year-old woman on long-term azathioprine.201829086996
evaluation of pd1/pdl1 expression and their clinicopathologic association in ebv-associated lymphoproliferative disorders in nonimmunosuppressed patients.epstein-barr virus (ebv)-associated lymphoproliferative disorders (lpd)/lymphomas in nonimmunosuppressed patients represent a unique entity and have been proposed to be related to immune senescence. engagement of programmed cell death 1 (pd1) by its ligand programmed death ligand 1 (pdl1) inhibits t-cell activation, and leads to t-cell exhaustion. in clinical trials, therapeutic antibodies that block the pd1-pdl1 axis have shown promising therapeutic activity in certain types of lymphomas. altho ...201729084057
[advances on epstein-barr virus related post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation]. 201729081206
[clinical features of mononucleosis because of epstein-barr virus and cytomegalovirus co-infection in adult patients].objective: to identify the clinical features of mononucleosis caused by co-infection of epstein-barr virus (ebv) and cytomegalovirus (cmv) in adult patients. methods: a total of 103 inpatients with mononucleosis in peking university third hospital from may 2013 to may 2016 were collected as the study subjects.the patients were divided into three groups according to the responsible pathogens: 33 patients infected with ebv and cmv, 53 infected with ebv alone and 17 infected with cmv alone.furtherm ...201729081150
cytokines associated with burkitt's lymphoma in western kenya.burkitt's lymphoma (bl) is a common aggressive non-hodgkin's lymphoma in east and central africa among children. persistent infections with epstein barr virus or plasmodium falciparum are associated with immune hyperstimulation. it is hypothesised that inadvertent cytokine responses to infections indirectly or directly influence b cell neoplastic transformation through c-myelocytomatosis (c-myc) gene translocation. we sought to describe cytokines in children and adolescents with bl. participants ...201729078819
is epstein-barr virus infection associated with the pathogenesis of microscopic colitis?epstein-barr virus (ebv) has been associated with inflammation in the colon, particularly in patients with inflammatory bowel disease (ibd). even if a relevant plasmocytosis, similar to ibd, is present in microscopic colitis (mc), the frequency of ebv infection in this setting is unknown.201729078077
18f-fdg pet for detection of primary tracheobronchial t-/natural killer-cell-derived posttransplant lymphoproliferative disorder after lung transplantation.posttransplant lymphoproliferative disorder (ptld) is a rare, but potentially devastating complication of solid organ transplantation. epstein-barr virus-associated ptlds of t-cell origin are exceedingly rare. we present the case of a 20-year-old man with extranasal t-/natural killer-cell-derived ptld after lung transplantation who underwent an f-fdg pet/ct scan for staging of disease. the f-fdg-pet scan demonstrated an unusual pattern of lymphomatous involvement limited to the recipients trache ...201729076909
multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer.multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and epstein barr virus, have been identified as separate infectious pathogens in human breast cancer. here we demonstrate that these four viruses may be present in normal and benign breast tissues 1 to 11 years before the development of same virus breast cancer in the same patients.201729075317
serology of viral infections and tuberculosis screening in an ibd population referred to a tertiary centre of southern italy.with the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. prevalence of the most important infectious agents may vary in different geographical areas. the aim of our study was to assess the immune status for hepatitis b, varicella, mononucleosis, and cytomegalovirus infection together with the determination of the hepatitis c and tuberculosis status in southern italy.201729075289
protective effect of rituximab in chronic graft-versus-host disease occurrence in allogeneic transplant patients with epstein barr virus viremia.b cells are involved in chronic graft-versus-host disease (cgvhd) pathogenesis, and rituximab may have a therapeutic effect on cgvhd in allogeneic hematopoietic stem cell transplantation (allo-hsct) patients. herein, we retrospectively evaluated the prophylactic effect of rituximab on cgvhd in a group of chinese allo-hsct patients. a total of 102 patients, who suffered epstein barr virus (ebv) viremia within 100 days after allo-hsct, were included in this study. fifty patients received rituximab ...201729075063
ebv latent membrane protein 2a orchestrates p27kip1 degradation via cks1 to accelerate myc-driven lymphoma in mice.epstein-barr virus (ebv) establishes lifelong infection in b lymphocytes of most human hosts and is associated with several b lymphomas. during latent infection, ebv encodes latent membrane protein 2a (lmp2a) to promote the survival of b cells by mimicking host b-cell receptor signaling. by studying the roles of lmp2a during lymphoma development in vivo, we found that lmp2a mediates rapid myc-driven lymphoma onset by allowing b cells to bypass myc-induced apoptosis mediated by the p53 pathway in ...201729074502
intratumoural pd-l1 expression is associated with worse survival of patients with epstein-barr virus-associated gastric cancer.this study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (pd-l1) and programmed cell death protein ligand-2 (pd-l2), in patients with epstein-barr virus-associated gastric cancer (ebvagc).201729073638
the epstein-barr virus b-zip protein zta recognizes specific dna sequences containing 5-methylcytosine and 5-hydroxymethylcytosine.the epstein-barr virus (ebv) b-zip transcription factor zta binds to many dna sequences containing methylated cg dinucleotides. using protein binding microarrays (pbms), we analyzed the sequence specific dna binding of zta to four kinds of double-stranded dna (dsdna): (1) dna containing cytosine in both strands, (2) dna with 5-methylcytosine (5mc) in one strand and cytosine in the second strand, (3) dna with 5-hydroxymethylcytosine (5hmc) in one strand and cytosine in the second strand, and (4) ...201729072898
human papillomavirus and world health organization type iii nasopharyngeal carcinoma: multicenter study from an endemic area in southern china.the current study was conducted to study the incidence of human papillomavirus (hpv)-associated nasopharyngeal carcinoma (npc) in southern china and the corresponding treatment outcome.201829072774
risk factors and clinical outcomes of pediatric liver transplant recipients with post-transplant lymphoproliferative disease in a multi-ethnic asian cohort.we aimed to evaluate clinical characteristics, risk factors, and disease outcomes for liver transplant recipients (ltr) with post-transplant lymphoproliferative disease (ptld) at our center.201729071779
two cases of angioimmunoblastic t-cell lymphoma with concomitant positive serology for acute epstein-barr virus infection. 201729071053
managing epstein-barr virus and other risk factors in ms-future, we discuss the rationale and feasibility of treatment directed against the modifiable risk factors in multiple sclerosis. the established environmental risk factors vitamin d insufficiency, cigarette smoke exposure, adolescence overweight, and epstein-barr virus infection are reviewed. already available measures to target these risk factors are discussed.201729068493
is the hygiene hypothesis relevant for the risk of multiple sclerosis?the hygiene hypothesis, suggesting that low exposure to pathogens early in life can increase the risk for immune-mediated diseases, has been proposed as an explanation for the increase in incidence of allergy and autoimmune diseases in industrialized countries during the last decades. several aspects of the hygiene hypothesis have been related to ms. already in 1966, the risk of ms was suggested to be higher in individuals with high hygienic standard during childhood. further, an episode of infe ...201729068485
the perivascular microenvironment in epstein-barr virus positive primary central nervous system lymphoma: the role of programmed cell death 1 and programmed cell death ligand has been shown that high expression of certain immune checkpoint molecules, including those of the programmed death protein 1/programmed death ligand 1 (pd-1/pd-l1) axis, can be utilized to regulate immunosuppression in the microenvironment of malignant neoplasms. for the purpose of clarifying the immune-escape mechanism of primary central nervous system lymphomas (pcnsls), particularly in epstein-barr virus (ebv)-positive cases, markers for pd-1, pd-l1, tumor-associated macrophages (tams), a ...201729067721
iatrogenic solid tumors following immunosuppressive therapy.immunosuppression induced by chronic medication, such as occurs post-transplantation, may increase a patient's risk of developing solid tumors. these are often rare tumors characterized by odd presentations. this review focuses on commonly encountered iatrogenic, non-hematopoietic solid tumors following immunotherapy and provides a practical approach to their diagnosis. all of the malignancies covered in this review are viral-induced. they include human papillomavirus (hpv)-associated carcinomas ...201729066044
the battle of rna synthesis: virus versus host.transcription control is the foundation of gene regulation. whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. just as cells are increasingly understood to employ nascent rnas in transcription regulation, recent discoveries are revealing how viruses use n ...201729065472
gammaherpesviral tegument proteins, pml-nuclear bodies and the ubiquitin-proteasome system.gammaherpesviruses like epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. in particular, viral tegument proteins that share sequence homology to the formylglycineamide ribonucleotide amidotransferase (fgarat, or pfas), an enzyme in the cellular purine biosynthesis, are important for disrupting the intrinsic antiviral response associated with promye ...201729065450
epstein-barr virus infection and oral squamous cell carcinoma risk: a meta-analysis.the evidence for association between epstein-barr virus (ebv) infection and risk of oral squamous cell carcinoma (oscc) is inconsistent in the literature. therefore, this meta-analysis was conducted to clarify this association.201729065191
an anergic immune signature in the tumor microenvironment of classical hodgkin lymphoma is associated with inferior outcome.the classical hodgkin lymphoma (chl) tumor microenvironment shows an ongoing inflammatory response consisting of varying degrees of infiltrating eosinophils, mast cells, macrophages, regulatory t lymphocytes (tregs), and activated lymphocytes surrounding the malignant cells. herein, different immune signatures are characterized and correlated with treatment outcome.201829064587
primary central nervous system extranodal nasal-type natural killer/t-cell lymphoma with cd20 expression.we report a unique case of primary cns extranodal natural killer/t-cell lymphoma (pcns enktcl) with cd20 expression and the monoclonal rearrangement of ig heavey chain (igh) gene. resection specimens were evaluated using he-stained sections, immunohistochemistry, in situ hybridization and pcr. histopathologic examination, immunohistochemistry and molecular studies showed the intermediate-sized lymphoma cells expressing cd2, cd3ε, granzyme b, tia-1, cd20 and epstein-barr virus-encoded rna, with g ...201729063643
analysis of immunogenicity of intracellular ctar fragments of epstein-barr virus latent phase protein lmp1.intracellular fragments of latent phase protein lmp1 of epstein-barr virus, denoted as ctar1/2/3, can trigger a variety of cell cascades and contribute to the transforming potential of the virus. generation of recombinant proteins ctar1/2/3 is expected to yield more ample data on functional and immunogenic characteristics of lmp1. we created genetic constructs for prokaryotic expression of lmp1 ctar fragments and selected optimal conditions for their production and purification. using a new libr ...201729063322
complete response of age-related epstein-barr virus-associated polymorphic nodal lymphoproliferative disease of plasmacytic type to low-dose lenalidomide. 201829063179
epstein-barr virus positive diffuse large b cell lymphoma with g17v rhoa mutation arising from peripheral t cell lymphoma, not otherwise specified. 201829063178
ebv-encoded ebna1 regulates cell viability by modulating mir34a-nox2-ros signaling in gastric cancer cells.epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is a viral protein expressed in all ebv-infected cells that induces malignant transformation. ebna1 is reported to contribute to tumor progression through an increase in reactive oxygen species via nicotinamide adenine dinucleotide phosphate oxidase. however, the underlying molecular mechanism of ebna1-induced ros accumulation in gastric cancer is poorly understood. here, we demonstrated that mir34a regulation by ebna1 determined cell fate in eb ...201729061308
impact of antiviral prophylaxis in adults epstein-barr virus-seronegative kidney recipients on early and late post-transplantation lymphoproliferative disorder onset: a retrospective cohort lymphoproliferative disorder (ptld) pathogenesis is related to ebv infection. mismatch with the donor (ebv d+/r-) is the main risk factor for both early ptld (<1 year post-transplantation) and late (>1 year). in these at-risk patients, the role of antiviral prophylaxis for preventing ptld remains controversial. we analyzed the impact of antiviral drugs given to prevent cmv disease in a monocentric retrospective cohort of 73 adult kidney or kidney-pancreas ebv-seronegative re ...201729057508
a phase ii study of methotrexate, etoposide, dexamethasone and pegaspargase sandwiched with radiotherapy in the treatment of newly diagnosed, stage ie to iie extranodal natural-killer/t-cell lymphoma, nasal-type.a phase ii study of methotrexate, etoposide, dexamethasone, and pegaspargase (mesa) sandwiched with radiotherapy for newly diagnosed, stage ie-iie extranodal natural-killer/t-cell lymphoma, nasal-type (enktl) was conducted to explore its clinical efficacy and safety, as well as novel serum biomarkers upon anti-metabolic treatment.201729056540
prognostic significance of standardized uptake value on f18-fdg pet/ct in patients with extranodal nasal type nk/t cell lymphoma: a multicenter, retrospective analysis.the purpose of this study was to evaluate the value of parameters assessed with f18-flurodeoxyglucose (fdg) positron emission tomography/computed tomography (pet/ct) in predicting relapse free survival and overall survival in patients with extranodal nasal type nk/t cell lymphoma.201729056243
malaria, epstein-barr virus, vitamin a and burkitt's lymphoma: response to joob and wiwanitkit. 201829055028
malaria, epstein-barr virus, vitamin a and burkitt's lymphoma. 201829055026
determination of molecular subtypes of diffuse large b-cell lymphoma using a reverse transcriptase multiplex ligation-dependent probe amplification classifier: a calym study.diffuse large b-cell lymphoma (dlbcl) is the most common non-hodgkin lymphoma. it includes three major subtypes termed germinal center b-cell-like, activated b-cell-like, and primary mediastinal b-cell lymphoma. with the emergence of novel targeted therapies, accurate methods capable of interrogating this cell-of-origin classification should soon become essential in the clinics. to address this issue, we developed a novel gene expression profiling dlbcl classifier based on reverse transcriptase ...201729054399
murine gammaherpesvirus 68: a small animal model for gammaherpesvirus-associated diseases.murine gammaherpesvirus 68 (mhv68) is a naturally occurring pathogen of murid rodents that is genetically related to the human gammaherpesviruses epstein-barr virus (ebv) and kaposi sarcoma-associated herpesvirus (kshv). viral, immunologic, and disease parameters following experimental infection of laboratory mice with mhv68 closely resemble what occurs during primary ebv infection of humans, which suggests that mhv68 infection of mice offers a small animal model to study in general the pathogen ...201729052141
ebv infection and glucose metabolism in nasopharyngeal establish persistent infection in cells, viruses evolve strategies to alter host cellular pathways to regulate cell proliferation and energy metabolism which support viral infection. epstein-barr virus (ebv) undergoes both lytic and latent infection to achieve persistent and lifelong infection in human. ebv readily infects human b cells, driving their transformation to proliferative lymphoblastoid cell lines (lcl), and eventually establishes lifelong latent infection in memory b cells. in con ...201729052133
current progress in ebv-associated b-cell lymphomas.epstein-barr virus (ebv) was the first human tumor virus discovered more than 50 years ago. ebv-associated lymphomagenesis is still a significant viral-associated disease as it involves a diverse range of pathologies, especially b-cell lymphomas. recent development of high-throughput next-generation sequencing technologies and in vivo mouse models have significantly promoted our understanding of the fundamental molecular mechanisms which drive these cancers and allowed for the development of the ...201729052132
magt1-mediated disturbance of mg2+ homeostasis lead to exhausted of hbv-infected nk and cd8+ t cells.the magnesium transporter 1 (magt1) is a critical regulator of basal intracellular free magnesium ([mg2+]i) levels. it has been shown that magt1 was involved in the disorder in mg2+ homeostasis after epstein-barr virus (ebv) infection. here, we identified the effects of magt1-mediated disturbance of mg2+ homeostasis on chronic hepatitis b virus (hbv)-infected natural killer (nk) and cd8+ t cells. the expression of magt1 was gradually decreased with the increase of infected time in cd8+ t cells, ...201729051561
characterization of the subcellular localization of epstein-barr virus encoded proteins in live cells.epstein-barr virus (ebv) is the pathogenic factor of numerous human tumors, yet certain of its encoded proteins have not been studied. as a first step for functional identification, we presented the construction of a library of expression constructs for most of the ebv encoded proteins and an explicit subcellular localization map of 81 proteins encoded by ebv in mammalian cells. viral open reading frames were fused with enhanced yellow fluorescent protein (eyfp) tag in eukaryotic expression plas ...201729050259
rare case of pulmonary lymphomatoid granulomatosis in conjunction with tuberculosis: a case report.lymphomatoid granulomatosis is a very rare epstein-barr virus-driven lymphoproliferative disease. this disease has high mortality owing to its low incidence in conjunction with nonspecific presentations, which contribute to delays in diagnosis.201729049243
chronic active epstein-barr virus infection as the initial symptom in a janus kinase 3 deficiency child: case report and literature review.with the progress of sequencing technology, an increasing number of atypical primary immunodeficiency (pid) patients have been discovered, including janus kinase 3 (jak3) gene deficiency.201729049190
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