oral bexarotene for post-transplant cutaneous t-cell lymphoma.organ transplant recipients receiving immunosuppression have an increased risk of developing post-transplant lymphoproliferative diseases (ptlds). traditionally, ptlds refer to epstein-barr virus (ebv)-induced b-cell lymphoma. however, post-transplant t-cell lymphoma may also occur and tends to have a poorer response to reduced immunosuppressive therapy. as such, additional therapy is often needed for post-transplant t-cell lymphoma, including post-transplant cutaneous t-cell lymphoma (pt-ctcl). ...201728748653
extranodal nk/t-cell lymphoma, nasal type, presenting as refractory pseudomonas aeruginosa facial cellulitis.extranodal natural killer t-cell lymphoma, nasal type (enkl), formerly called lethal midline granuloma or angiocentric t-cell lymphoma, is a predominantly extranodal non-hodgkin lymphoma characterized by vascular damage, necrosis, and an association with epstein-barr virus. in the united states, it is more frequently seen in asian, asian pacific islander, and hispanic descent populations and is more prevalent in males in their fifth decade. clinical presentation of nk nasal lymphoma most commonl ...201728748192
erratum: defective t-cell control of epstein-barr virus infection in multiple sclerosis.[this corrects the article doi: 10.1038/cti.2016.87.].201728748090
clinical significance of four molecular subtypes of gastric cancer identified by the cancer genome atlas project.purpose: the cancer genome atlas (tcga) project recently uncovered four molecular subtypes of gastric cancer: epstein-barr virus (ebv), microsatellite instability (msi), genomically stable (gs), and chromosomal instability (cin). however, their clinical significances are currently unknown. we aimed to investigate the relationship between subtypes and prognosis of patients with gastric cancer.experimental design: gene expression data from a tcga cohort (n = 262) were used to develop a subtype pre ...201728747339
acute epstein-barr virus encephalitis in an immunocompetent adolescent patient. 201728746439
epstein-barr virus positivity is associated with angiogenesis in, and poorer survival of, patients receiving standard treatment for classical hodgkin's lymphoma.epstein-barr virus (ebv) is a significant contributor to the development of classical hodgkin's lymphoma (chl). recent studies have documented associations between angiogenesis and ebv-associated malignancies. no study has yet examined the associations among, and prognostic implications of, ebv infection, vascular endothelial growth factor (vegf) expression, and microvessel density (mvd) in chl patients. diagnostic tissues from 135 chl patients treated with adriamycin, bleomycin, vinblastine, an ...201728744882
evaluation of antigen-specific igm and igg production during an in vitro peripheral blood mononuclear cell culture assay.the recent attention given to diseases associated with memory b-cell (mbc)-produced antibodies (abs) suggests the need for a similar in vitro assay to evaluate the functions of mbcs. here, we cultured peripheral blood mononuclear cells (pbmcs) with the intent to collect mbc-derived abs in vitro and maintain their cell-cell contact-dependent interactions with helper t-cells. pbmcs were cultured with interleukin (il)-21, cpg-oligodeoxynucleotides (odn), phorbol myristate acetate (pma), and phytohe ...201728740496
collision of lymphoepithelioma-like carcinoma with diffuse large b-cell lymphoma of the stomach: a case report.collision of epstein-barr virus (ebv)-associated lymphoepithelioma-like carcinoma (lelc) with non-hodgkin's lymphoma of the stomach is extremely rare.201728739754
distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen.correct positioning of dendritic cells (dcs) is critical for efficient pathogen encounter and antigen presentation. epstein-barr virus-induced gene 2 (ebi2) has been identified as a chemoattractant receptor required for naïve cd4(+)dcir2(+) dc positioning in response to 7α,25-hydroxycholesterol (7α,25-hc). we now provide evidence that a second ebi2 ligand, 7α,27-hc, is involved in splenic dcir2(+) dc positioning and homeostasis. cyp27a1, the enzyme uniquely required for 7α,27-hc synthesis, is ex ...201728738017
rps27a enhances ebv-encoded lmp1-mediated proliferation and invasion by stabilizing of lmp1.epstein-barr virus (ebv)-encoded latent membrane protein 1 (lmp1) is an oncoviral protein that plays a pivotal role in ebv-induced oncogenic transformation. the function of lmp1 in ebv-induced oncogenesis has been well studied. however, the molecular mechanisms underlying lmp1 protein stability remain poorly understood. in this study, we found that ribosomal protein s27a (rps27a) regulates lmp1 stability by a tandem affinity purification analysis. rps27a interacts directly with lmp1 in vitro and ...201728735865
association of clinical and serological parameters of systemic lupus erythematosus patients with epstein-barr virus antibody profile.epstein-barr viral infection is one of the known environmental factors involved in development of systemic lupus erythematous (sle). though not much is known about the exact role of ebv in sle pathogenesis, the theory of switching of lytic and lysogenic cycles of epstein-barr virus in memory b-cells fits well with the periods of waning disease activity and intermittent flares in sle patients. in this study, we investigate the association of ebv antibody profile with clinical and serological para ...201728734074
lmp1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma.myeloid-derived suppressor cells (mdscs) are expanded in tumor microenvironments, including that of epstein-barr virus (ebv)-associated nasopharyngeal carcinoma (npc). the link between mdsc expansion and ebv infection in npc is unclear. here, we show that ebv latent membrane protein 1 (lmp1) promotes mdsc expansion in the tumor microenvironment by promoting extra-mitochondrial glycolysis in malignant cells, which is a scenario for immune escape initially suggested by the frequent, concomitant de ...201728732079
exploring the effect of vitamin d3 supplementation on the anti-ebv antibody response in relapsing-remitting multiple sclerosis.epstein-barr virus (ebv) infection and vitamin d insufficiency are potentially interacting risk factors for multiple sclerosis (ms).201728731372
role of epstein-barr virus in the development of nasopharyngeal carcinoma.southern china experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which epstein-barr virus (ebv) infection is the mostly investigated. the study into mechanism of ebv in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. the pathophysiology ...201728730175
exposure to the epstein-barr viral antigen latent membrane protein 1 induces myelin-reactive antibodies in vivo.multiple sclerosis (ms) is an autoimmune chronic inflammatory disease of the central nervous system (cns). cross-reactivity of neuronal proteins with exogenous antigens is considered one of the possible mechanisms of ms triggering. previously, we showed that monoclonal myelin basic protein (mbp)-specific antibodies from ms patients cross-react with epstein-barr virus (ebv) latent membrane protein 1 (lmp1). in this study, we report that exposure of mice to lmp1 results in induction of myelin-reac ...201728729867
the epstein-barr virus brrf1 gene is dispensable for viral replication in hek293 cells and transformation.the epstein-barr virus (ebv) is a gamma-herpesvirus associated with several malignancies. it establishes a latent infection in b lymphocytes and is occasionally reactivated to enter the lytic cycle. here we examined the role of the ebv gene brrf1, which is expressed in the lytic state. we first confirmed, using a dna polymerase inhibitor, that the brrf1 gene is expressed with early kinetics. a brrf1-deficient recombinant virus was constructed using a bacterial artificial chromosome system. no ob ...201728729695
p53 deregulation in epstein-barr virus-associated gastric cancer.tp53 is a tumour suppressor gene frequently mutated in human cancers; nevertheless, in ebv-associated malignancies mutations are uncommon despite frequent deregulation of the p53 pathway. in this study, we aimed to investigate p53 expression, tp53 mrna levels and tp53 mutations in ebv-associated gastric carcinoma (ebvagc). a case-control study was performed using 46 patients: 15 ebvagc and 31 ebv-negative gc (ebvngc) cases. p53 expression was detected by immunohistochemistry (ihc), the evaluatio ...201728729047
approaches to controlled co-amplification of genes for production of biopharmaceuticals: study of the insertion and amplification dynamics of genetic cassettes in the genome of chinese hamster ovary cells during co-expression of compatible pair of plasmids.plasmid vector family p1.1 based on non-coding regions of chinese hamster housekeeping gene eef1a and concatemer of epstein-barr virus terminal repeat increases the frequency of genome integration and provides rapid amplification of the target genes in the genome. for a pair of fluorescent proteins egfp and mcherry it was shown that p1.1 vectors bearing dihydrofolate reductase and glutamine synthetase selection markers upon co-transfection into cho dg44 cell line allow obtaining a polyclonal cel ...201728726207
epstein-barr virus (ebv)-associated epithelial and non-epithelial lesions of the oral cavity.epstein-barr virus (ebv) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (lpds) in immunocompromised patients. ebv, a b-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. furthermore, ebv is associated with epithelial malignancies such as nasopharyngeal carcinoma (npc), salivary gland tumor, gastric carcinoma and breast carcinoma. in terms ...201728725300
viral driven epigenetic events alter the expression of cancer-related genes in epstein-barr-virus naturally infected burkitt lymphoma cell lines.epstein-barr virus (ebv) was identified as the first human virus to be associated with a human malignancy, burkitt's lymphoma (bl), a pediatric cancer endemic in sub-saharan africa. the exact mechanism of how ebv contributes to the process of lymphomagenesis is not fully understood. recent studies have highlighted a genetic difference between endemic (ebv+) and sporadic (ebv-) bl, with the endemic variant showing a lower somatic mutation load, which suggests the involvement of an alternative vir ...201728724958
translesion polymerase, pol η, is required for efficient epstein-barr virus infectivity and is regulated by the viral deubiquitinating enzyme, bplf1.epstein-barr virus (ebv) infection and lytic replication are known to induce a cellular dna damage response. previously we showed that the virally encoded bplf1 protein interacts with and regulates several members of the translesion synthesis pathway (tls), a dna damage tolerance pathway, and that these cellular factors enhance viral infectivity. bplf1 is a late lytic cycle gene, but the protein is also packaged in the viral tegument indicating that bplf1 may function both early and late during ...201728724765
monoamine oxidase a is highly expressed in classical hodgkin lymphoma.monoamine oxidase a (maoa) is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines and produces h2 o2. it facilitates the progression of gliomas and prostate cancer, but its expression and functional relevance have not been studied in lymphoma. here, we evaluated maoa in 427 cases of hodgkin and non-hodgkin lymphoma and in a spectrum of reactive lymphoid tissues by immunohistochemistry on formalin-fixed paraffin-embedded specimens. maoa was expresse ...201728722111
clinical utility of epstein-barr virus dna testing in the treatment of nasopharyngeal carcinoma patients.epstein-barr virus (ebv) dna analysis has been shown to be useful for early detection, prognostication, and monitoring of treatment response of nasopharyngeal carcinoma (npc), and the recent literature provides growing evidence of the clinical utility of ebv dna testing, particularly to inform treatment decisions for npc patients. despite the fact that npc is a rare disease, the nrg oncology cooperative group has successfully activated a phase 2/3 randomized clinical trial for npc with internati ...201728721913
a prospective study of infectious mononucleosis in college students.the present study aims to prospectively investigate possible biological and psychological factors present in college students who will go on to develop chronic fatigue syndrome (cfs) following infectious mononucleosis (im). identification of risk factors predisposing patients towards developing cfs may help to understand the underlying mechanisms and ultimately prevent its occurrence. our study is enrolling healthy college students over the age of 18. enrollment began in march of 2013 and is ong ...201728717787
methotrexate-associated lymphoproliferative disorder in a patient with neuromyelitis optica spectrum disorder: an implication for pathogenesis mediated by epstein-barr virus. 201728716244
quantitation of dna methylation in epstein-barr virus-associated nasopharyngeal carcinoma by bisulfite amplicon sequencing.epigenetic changes, including dna methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. nasopharyngeal carcinoma (npc) is endemic in southern china and is highly associated with epstein-barr virus (ebv) infection. significant changes of the host cell methylome are observed in ebv-associated npc with cancer development. epigenetic marks for npc diagnosis are urgently needed. in order to explore dna methylation marks, we investigated dna methylation of c ...201728716111
small molecule perturbation of the cand1-cullin1-ubiquitin cycle stabilizes p53 and triggers epstein-barr virus reactivation.the chemical probe c60 efficiently triggers epstein-barr virus (ebv) reactivation from latency through an unknown mechanism. here, we identify the cullin exchange factor cand1 as a biochemical target of c60. we also identified cand1 in an shrna library screen for ebv lytic reactivation. gene expression profiling revealed that c60 activates the p53 pathway and protein analysis revealed a strong stabilization and s15 phosphorylation of p53. c60 reduced cullin1 association with cand1 and led to a g ...201728715492
nutlin-3, a p53-mdm2 antagonist for nasopharyngeal carcinoma treatment.nasopharyngeal carcinoma (npc) is a form of head and neck cancer of multifactorial etiologies that is highly prevalent among men in the populations of southern china and southeast asia. npc has claimed many thousands of lives worldwide; but the low awareness of npc remains a hindrance in early diagnosis and prevention of the disease. npc is highly responsive to radiotherapy and chemotherapy, but radiocurable npc is still dependent on concurrent treatment of megavoltage radiotherapy with chemothe ...201728714398
clinical usefulness of f-18 fdg pet in lymphoepithelioma-like gastric carcinoma.lymphoepithelioma-like carcinoma (lelc) is a rare type of gastric cancer. we evaluated the clinical usefulness of f-18 fdg positron emission tomography/computed tomography (pet/ct) in lelc of stomach.201728712702
expression of interferon regulatory factor 7 correlates with the expression of epstein-barr virus latent membrane protein 1 and cervical lymph node metastasis in nasopharyngeal cancer.interferon regulatory factor 7 (irf7) has oncogenic properties in several malignancies such as epstein-barr virus (ebv)-associated lymphoma. however, there is no evidence whether irf7 is associated with the oncogenesis of nasopharyngeal cancer (npc), the pathogenesis of which is closely associated with ebv. herein, we report that expression of irf7 was increased in normal nasopharyngeal cells that expressed the ebv principal oncoprotein, latent membrane protein 1 (lmp1). in addition, irf7 was ma ...201728712115
anti-n-methyl-d-aspartate receptor encephalitis and epstein-barr virus: another tale on autoimmunity? 201728707812
pretreatment serum amyloid a and c - reactive protein comparing with epstein-barr virus dna as prognostic indicators in patients with nasopharyngeal carcinoma: a prospective study.the measuring epstein-barr virus (ebv) dna is an important predictor of nasopharyngeal carcinoma (npc). this study evaluated the predictive value of pretreatment serum amyloid a (saa) and c-reactive protein (crp) comparing with ebv dna in patients with npc.201728707462
malaria, epstein-barr virus infection and the pathogenesis of burkitt's lymphoma.a geographical and causal connection has long been recognized between malaria, epstein-barr virus (ebv) infection and burkitt's lymphoma (bl), but the underlying mechanisms remain obscure. potential clues are that the malaria parasite plasmodium falciparum selectively absorbs vitamin a from the host and depends on it for its biological activities; secondly, alterations in vitamin a (retinoid) metabolism have been implicated in many forms of cancer, including bl. the first author has proposed tha ...201728707393
epstein-barr virus lytic cycle involvement in diffuse large b cell lymphoma.epstein-barr virus (ebv)-mediated b cell transformation is achieved predominantly through the action of latent proteins, but recent evidence suggests that lytic ebv replication has also a certain pathogenic role in lymphomagenesis, at least in the early phases of cell transformation. particularly, in diffuse large b cell lymphoma (dlbcl), the ebv lytic cycle is by and large unexplored, so to disclose lytic cell contribution to lymphomagenesis, our aim was to evaluate viral early and late lytic g ...201728707331
clinical utility of epstein-barr virus viral load monitoring and risk factors for posttransplant lymphoproliferative disorders after kidney transplantation: a single-center, 10-year observational cohort study.posttransplant lymphoproliferative disease (ptld) is an important cause of morbidity and mortality in solid organ transplants. epstein barr virus (ebv) plays a major role in ptld development. guidelines recommend ebv viral load (vl) monitoring in high-risk populations in the first year.201728706985
the anecdote of viral etiopathogenia in ameloblastoma and odontogenic keratocyst: why don't we let it go?ameloblastoma (am) and odontogenic keratocyst (okc) are destructive odontogenic lesions of the gnathion. although their exact pathogeneses are not yet totally understood, the viral etiopathogenesis in am and kcot has been proposed. true to syndromic keratocystic odontogenic tumor (skcot) and non-syndromic okc is the high recurrence rate.201728706783
an immunocompetent patient with a recurrence-free ebv positive plasmacytoma possesses robust epstein-barr virus specific t cell responses. 201728705903
prevalence of ebv, hpv and mmtv in pakistani breast cancer patients: a possible etiological role of viruses in breast cancer.breast cancer being a multifactorial disease, the role of infectious agent in development of disease is of great interest. the high incidence of breast cancer around the world has woken the interest in a viral etiology of breast cancer. despite decades of research, no etiologic factor(s) for human breast cancer has been known and the quest for a contributing cause has all but been abandoned during the past years. recent investigations have linked breast cancer to viral infections, such as epstei ...201728705719
conserved sequences of bart and bhrf regions encoding viral micrornas in epstein-barr virus-associated lymphoma.epstein-barr virus (ebv) encodes at least 25 pri-micrornas (mirnas) in two regions of its dna genome, bart and bhrf. b95-8, an ebv reference strain, has a deletion in the bart region. however, no information is available on the deletions or mutations in the bart and bhrf regions in clinical samples of ebv-associated lymphoma.201728705173
acute generalized exanthema tous pustulosis (agep) associated to epstein-barr virus (ebv) infection reactivation. 201728704988
effects of a new nutraceutical formulation (berberine, red yeast rice and chitosan) on non-hdl cholesterol levels in individuals with dyslipidemia: results from a randomized, double blind, placebo-controlled study.increased non high-density lipoprotein (hdl)/low-density lipoprotein (ldl) cholesterol levels are independent risk factors for cardiovascular (cv) mortality with no documented threshold. a new combination of nutraceuticals (berberine 200 mg, monacolin k 3 mg, chitosan 10 mg and coenzyme q 10 mg) with additive lipid-lowering properties has become available. the aim of the study is to test the efficacy of the nutraceutical formulation (one daily) in lowering non-hdl cholesterol vs. placebo at 12 w ...201728704936
persistent kshv infection increases ebv-associated tumor formation in vivo via enhanced ebv lytic gene expression.the human tumor viruses epstein-barr virus (ebv) and kaposi sarcoma-associated herpesvirus (kshv) establish persistent infections in b cells. kshv is linked to primary effusion lymphoma (pel), and 90% of pels also contain ebv. studies on persistent kshv infection in vivo and the role of ebv co-infection in pel development have been hampered by the absence of small animal models. we developed mice reconstituted with human immune system components as a model for kshv infection and find that ebv/ks ...201728704654
eb virus reactivation triggers thrombotic thrombocytopenic purpura in a healthy adult.thrombotic thrombocytopenic purpura (ttp) is rare but life-threatening disease, characterized typically by microangiopathic hemolytic anemia (maha), profound peripheral thrombocytopenia and severe deficiency in the von willebrand factor-cleaving prortease adamts13. it has been reported that acquired immune ttp is closely associated with human immunodeficiency virus infection and influenza infection or vaccination. however, it has not been reported to be associated with epstein barr virus infecti ...201728702343
acute epstein - barr virus hepatitis without mononucleosis syndrome: a case report.elevated liver enzymes accompanied by infectious mononucleosis syndrome are widely seen in primary epstein-barr virus infection while acute symptomatic hepatitis without typical presentations of ebv is extremely rare. in the following report, we present a patient with acute isolated hepatitis due to laboratory confirmed epstein-barr virus.201728702140
structure and functional basis for an ebna1 hexameric ring in epstein-barr virus episome maintenance.epstein-barr virus (ebv) establishes a stable latent infection that can persist for the life of the host. ebna1 is required for the replication, maintenance, and segregation of the latent episome but the structural features of ebna1 that confer each of these functions are not completely understood. here, we have solved the x-ray crystal structure of an ebna1 dna binding domain (dbd) and discovered a novel hexameric ring oligomeric form. the oligomeric interface pivoted around residue t585 as a j ...201728701406
the 150 most important questions in cancer research and clinical oncology series: questions 40-49.since the beginning of 2017, chinese journal of cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. in this article, 10 more questions are presented as followed. question 40. why do mice being used as tumorigenesis models raised in different places or different conditions possess different tumor formation rate? question 41. how ...201728701224
aged-associated cytomegalovirus and epstein-barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women.immunosenescence is an age-related reduction of immune system activity that can be associated with frailty. this study aimed to compare cytomegalovirus (cmv) and epstein-barr virus (ebv) reactivations (based on viremias) between young and elderly women who had a chronic cmv and/or ebv infection (i.e., an igg+ serostatus) without an acute infection (i.e., an igm- serostatus), and among the elderly group categorized according to frailty status. dna was extracted from plasma using standard protocol ...201728700679
an unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: a case the adult patient, hemophagocytic lymphohistiocytosis (hlh) is uncommon and frequently difficult to diagnose due to its nonspecific presentation and numerous complications.201728700492
epstein-barr virus (ebv) provides survival factors to ebv(+) diffuse large b-cell lymphoma (dlbcl) lines and modulates cytokine induced specific chemotaxis in ebv(+) dlbcl.diffuse large b-cell lymphoma (dlbcl), the most common type of malignant lymphoma, accounts for 30% of adult non-hodgkin lymphomas. epstein-barr virus (ebv) -positive dlbcl of the elderly is a newly recognized subtype that accounts for 8-10% of dlbcls in asian countries, but is less common in western populations. five dlbcl-derived cell lines were employed to characterize patterns of ebv latent gene expression, as well as response to cytokines and chemotaxis. interleukin-4 and interleukin-21 mod ...201728699226
dual non-contiguous peptide occupancy of hla class i evoke antiviral human cd8 t cell response and form neo-epitopes with cd8 t cell response to viral infections involves recognition of 8-10-mer peptides presented by mhc-i molecules. however, proteasomes generate predominantly 2-7-mer peptides, but the role of these peptides is largely unknown. here, we show that single short peptides of <8-mer from latent membrane protein 2 (lmp2) of epstein barr virus (ebv) can bind hla-a*11:01 and stimulate cd8(+) cells. surprisingly, two peptide fragments between 4-7-mer derived from lmp2(340-349) were able to complement e ...201728698575
primary intra-aortic epstein-barr virus-positive large b-cell lymphoma presenting as aortic mural thrombosis: an entity distinct from intravascular large b-cell lymphoma.intravascular selective growth of neoplastic b lymphocytes is a characteristic finding of intravascular large b-cell lymphoma (ivlbcl). however, because neoplastic b cells of ivlbcl grow merely in the lumina of capillaries or small vessels, primary ivlbcl of the great vessels is considered exceptional. to our knowledge, only 2 primary b-cell lymphomas in the lumina of the vena cava have been reported. however, there has been no report of primary b-cell lymphoma with intra-aortic growth. we descr ...201728697692
systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood with good response to steroid therapy.systemic epstein-barr virus (ebv)-positive t-cell lymphoproliferative disease of childhood is a rare disease and has a very fulminant clinical course with high mortality. a 21-month-old female patient was referred to our hospital with a 1 week history of fever and was subsequently diagnosed with systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood. after starting treatment with dexamethasone, she showed early defervescence and improvement of laboratory parameters, ...201728697169
lipschütz ulcers: a rare diagnosis in women with vulvar ulceration.lipschütz ulcers are characterized by painful vulvar ulceration, most commonly in young women. because these lesions are so rarely seen, the diagnosis can be challenging.201728697104
epstein-barr virus-negative extranodal "true" natural killer-cell lymphoma harbouring a kdm6a mutation.extranodal natural killer (nk)/t-cell lymphoma, nasal type (enktl) is an extranodal aggressive t or nk-cell lymphoma that is characteristically associated with epstein-barr virus (ebv) infection and cytotoxic tissue-destructive features. although enktl is described as a distinct entity according to the 2008 who classification, a considerable complexity is associated with the differential diagnosis of other t-cell lymphomas with respect to tumour cell origins, locations, and the presence of ebv i ...201728695659
role of sirt1/pgc-1α in mitochondrial oxidative stress in autistic spectrum disorder.autistic spectrum disorder (asd) is a neurodevelopmental disorder and has a high prevalence in children. recently, mitochondrial oxidative stress has been proposed to be associated with asd. besides, sirt1/pgc-1α signaling plays an important role in combating oxidative stress. in this study, we sought to determine the role of sirt1/pgc-1α signaling in the asd lymphoblastoid cell lines (lcls). in this study, the mrna and protein expressions of sirt1/pgc-1α axis genes were assessed in 35 children ...201728694700
primary gastrointestinal anaplastic large cell lymphoma.primary gastrointestinal anaplastic large cell lymphoma (gi-alcl) is rare. we report eight new cases. the median age was 61.5 years (range 10-88), most frequently involving the stomach (n = 3) and small intestine (n = 4). the neoplastic hallmark cells in all cases expressed cd30. anaplastic lymphoma kinase (alk) protein was expressed in two cases (25%). by in situ hybridisation, all cases were negative for epstein-barr virus and for dusp22/irf4 gene translocation. at a median follow-up time of 3 ...201728693749
prognostic role of tumor infiltrating lymphocytes in ebv positive and ebv negative nasopharyngeal carcinoma.tumor infiltrating lymphocytes (tils) correlate with both better and worse prognosis in solid tumors. as therapeutic modalities for nasopharyngeal carcinoma (npc) are limited, immunotherapy could be a potential alternative. up till now there is limited prognostic data on the role of tils in npc, so we assessed the prognostic role of tils in epstein-barr-virus (ebv) positive and negative npc.201728688685
mycoplasma pneumoniae as a cause of vulvar ulcers in a non-sexually active girl: a case report.non-sexually active young females very rarely develop genital ulcers. such ulcers pose a diagnostic challenge as well as physical and emotional distress for patients and family; therefore, the search for their etiology requires exhaustive investigation. several viruses such as epstein-barr virus have been associated with this entity; however, mycoplasma pneumoniae has rarely been linked to such ulcers in the literature. we present a case of vulvar ulcers in a non-sexually active young girl durin ...201728688453
a rare case of epstein-barr virus mucocutaneous ulcer of the colon.epstein-barr virus mucocutaneous ulcer (ebvmcu) is a rare form of ebv lymphoproliferative disorder. the disease was recently described in 2010 for the first time in a case series and it was recently identified by the who classification of haematological malignancies as a separate category among the ebv lymphoproliferative disorders. we present a case of ebvmcu of the colon presenting as an ulcerating inflammatory mass in a female in her mid-60s who presented initially with abdominal pain and dia ...201728687701
nucleolin directly mediates epstein-barr virus immune evasion through binding to g-quadruplexes of ebna1 mrna.the oncogenic epstein-barr virus (ebv) evades the immune system but has an achilles heel: its genome maintenance protein ebna1, which is essential for viral genome maintenance but highly antigenic. ebv has seemingly evolved a system in which the mrna sequence encoding the glycine-alanine repeats (gar) of the ebna1 protein limits its expression to the minimal level necessary for function while minimizing immune recognition. here, we identify nucleolin (ncl) as a host factor required for this proc ...201728685753
iatrogenic immunodeficiency-associated epstein-barr virus (ebv) -negative natural killer cell lymphoproliferative disorder in a patient undergoing rheumatoid arthritis we present a patient with rheumatoid arthritis (ra), who was suspected to have developed malignant lymphoma during immunosuppressive therapy 5 years earlier. she temporarily achieved remission after discontinuing therapy; however, her disease worsened with remittent fever and splenomegaly. splenic biopsy demonstrated infiltration by abnormal cells, which were positive for cd56 and t cell intracytoplasmic antigen, but negative for cd3 and epstein-barr virus (ebv) -encoded rna. cytogenetic an ...201728679993
virus-specific cytotoxic t cells in chronic active epstein-barr virus infection.chronic active epstein-barr virus infection (caebv) is a disease characterized by clonally proliferating and activated ebv-infected t or nk cells accompanied by chronic inflammation and t- or nk-cell neoplasms. however, the mechanism for developing caebv has not been clarified to date. because the decreased number or inactivation of ebv-specific cytotoxic t lymphocytes (ctls) resulted in the development of ebv-positive b-cell neoplasms, we investigated the number of ctls in caebv patients using ...201728679986
current treatment approaches for nk/t-cell lymphoma.extranodal nk/t-cell lymphoma, nasal type (enkl), is a form of lymphoma characterized by preferential extranodal involvement, epstein-barr virus (ebv) association, and geographic diversity in incidence. enkl tumor cells express p-glycoprotein, which is related to multidrug resistance (mdr). this mdr phenomenon is thought to be the major reason why enkl is resistant to anthracycline-containing chemotherapies and has led researchers to explore novel therapeutic strategies. since the early 2000s, n ...201728679966
radiation-induced epstein-barr virus reactivation in gastric cancer cells with latent ebv infection.epstein-barr virus, a ubiquitous human herpes virus with oncogenic activity, can be found in 6%-16% of gastric carcinomas worldwide. in epstein-barr virus-associated gastric carcinoma, only a few latent genes of the virus are expressed. ionizing irradiation was shown to induce lytic epstein-barr virus infection in lymphoblastoid cell lines with latent epstein-barr virus infection. in this study, we examined the effect of ionizing radiation on the epstein-barr virus reactivation in a gastric epit ...201728675108
evaluation of seven recombinant vca-iga elisa kits for the diagnosis of nasopharyngeal carcinoma in china: a case-control recombinant viral capsid antigen-iga (vca-iga) elisa kits are widely used in china, but their diagnostic effects have not been evaluated. in this study, we evaluated whether the diagnostic effects of these kits are similar to those of the standard kit (euroimmun, lübeck, germany).201728674124
clinical analysis of 42 cases of ebv-positive mature t/nk-cell neoplasms.the pathogenesis of epstein-barr virus-positive (ebv(+)) mature t-cell and natural killer (nk)-cell neoplasms is challenging to understand. the clinical features are diverse, with no typical manifestation. therefore, it is important to analyze the association of the clinical characteristics and prognoses of patients with various factors associated with ebv(+) t/nk-cell neoplasms, particularly extranodal nk/t cell lymphoma, systemic ebv(+) t/nk cell lymphoproliferative disorders, aggressive nk ce ...201728672968
molecular screening for epstein-barr virus (ebv): detection of genomic ebna-1, ebna-2, lmp-1, lmp-2 among vietnamese patients with nasopharyngeal brush samplesepstein-bar virus (ebv) is considered to be intimately associated with development of nasopharyngeal carcinoma (npc), the most common and high incidence cancer of the head and neck in asian countries, especially in vietnam. in this study, we validated associations between highly conserved segments of the ebv genome, including ebna-1, ebna-2, lmp-1, lmp-2 and nasopharyngeal cancer, with the aim of applications with non-invasive brush samples for early diagnosis and as a prognostic biomarker. the ...201728670888
an update: epstein-barr virus and immune evasion via microrna regulation.epstein-barr virus (ebv) is an oncogenic virus that ubiquitously establishes life-long persistence in humans. to ensure its survival and maintain its b cell transformation function, ebv has developed powerful strategies to evade host immune responses. emerging evidence has shown that micrornas (mirnas) are powerful regulators of the maintenance of cellular homeostasis. in this review, we summarize current progress on how ebv utilizes mirnas for immune evasion. ebv encodes mirnas targeting both v ...201728669004
co-infections by double-stranded dna viruses after ex vivo t cell-depleted, cd34(+) selected hematopoietic cell transplantation.recipients of ex vivo t cell-depleted (tcd) hematopoietic cell transplantation (hct) are at risk of infection by double-stranded (ds) dna viruses. we report rates of dsdna viremia, end-organ disease (eod), infection-related mortality, and overall survival (os) in a contemporary cohort of adult tcd hct recipients routinely monitored for cytomegalovirus (cmv), adenovirus (adv), human herpesvirus 6 (hhv6), and epstein-barr virus (ebv). healthcare utilization in the first 6 months post-hct was compa ...201728668490
post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14).post-transplant lymphoproliferative disorders (ptld) are emergent complications of organ transplantation occurring in 2% to 10% of transplanted patients. epstein-barr virus (ebv) infections are considered the most important factors for the development of these heterogeneous disorders. primary effusion lymphoma (pel) is a lymphoproliferative disorder predominantly described in patients with advanced aids and it is almost universally associated with human herpesvirus 8 (hhv8). in rare case, pel al ...201728667038
posttransplant lymphoproliferative disease and inhibitors of mammalian target of rapamycin: when a quick look back can change the perspective.posttransplant lymphoproliferative disease represents a heterogeneous group of diseases characterized by uncontrolled proliferation of lymphocytes, favored by immunosuppression. several risk factors for its development have been described, with epstein-barr virus infection being a main cause of early-onset forms and chronic antigen stimulation of donors and/or accumulated immunosuppression as key factors of later forms of lymphocyte transformation. the present clinical case presents a patient di ...201728666406
evaluation the architect ebv vca igm, vca igg, and ebna-1 igg chemiluminescent immunoassays to assess ebv serostatus prior transplantation.prior to transplantation of hematopoietic stem cells or solid organ, donor and recipient ebv serostatus has to be determined to assess risks of post-transplant lymphoproliferative disorders. sensitivity of ebv viral capsid antigens (vca) igg and ebv nuclear antigen-1 (ebna-1) is critical to define past infection and a good specificity of vca igm is required to avoid any disqualification of cord blood (cb) units. architect™ ebv antibody panel (architect assay) providing a high throughput was comp ...201728661055
prevention of human lymphoproliferative tumor formation in ovarian cancer patient-derived xenografts.interest in preclinical drug development for ovarian cancer has stimulated development of patient-derived xenograft (pdx) or tumorgraft models. however, the unintended formation of human lymphoma in severe combined immunodeficiency (scid) mice from epstein-barr virus (ebv)-infected human lymphocytes can be problematic. in this study, we have characterized ovarian cancer pdxs which developed human lymphomas and explore methods to suppress lymphoproliferative growth. fresh human ovarian tumors fro ...201728658648
inflammatory myofibroblastic tumor of the lumbar spinal canal: a case report with literature review.inflammatory myofibroblastic tumor (imt) is a rare type of mesenchymal tumor. imt can arise in multiple anatomic locations. imt of the lumbar spinal canal is exceptionally rare.201728658093
methotrexate-related lymphoproliferative disorder in patients with osteonecrosis of the jaw: a 3-case report and literature review.patients with immunodeficiency or immunosuppression are at risk of developing a lymphoproliferative disorder (lpd). methotrexate (mtx) is an iatrogenic cause of lpd, which in up to 50% cases occurs in extranodal sites. the occurrence of mtx-related lpd with osteonecrosis of the jaw (onj) has rarely been reported. moreover, there are no clear diagnostic criteria and treatment strategies for management of these lesions. in the present cases, discontinuing mtx and debridement of the necrotic bone w ...201728654766
genetic factors affecting ebv copy number in lymphoblastoid cell lines derived from the 1000 genome project samples.epstein-barr virus (ebv), human herpes virus 4, has been classically associated with infectious mononucleosis, multiple sclerosis and several types of cancers. many of these diseases show marked geographical differences in prevalence, which points to underlying genetic and/or environmental factors. those factors may include a different susceptibility to ebv infection and viral copy number among human populations. since ebv is commonly used to transform b-cells into lymphoblastoid cell lines (lcl ...201728654678
lmp1 and dynamic progressive telomere dysfunction: a major culprit in ebv-associated hodgkin's lymphoma.epstein-barr virus (ebv)-encoded latent membrane protein 1 (lmp1) is expressed in germinal-center-derived, mononuclear hodgkin (h) and multinuclear, diagnostic reed-sternberg (rs) cells in classical ebv-positive hodgkin's lymphoma (chl). lmp1 expression in ebv-negative h-cell lines results in a significantly increased number of rs cells. in a conditional, germinal-center-derived b-cell in vitro system, lmp1 reversibly down-regulates the shelterin proteins, telomeric repeat binding factor (trf)1, ...201728654015
no effect of treatment with intravenous ganciclovir on epstein-barr virus viremia demonstrated after pediatric liver transplantation.ebv after pediatric lt is a risk factor for ptld. we wanted to evaluate the effect of intravenous ganciclovir on ebv viremia and to identify risk factors for chronic ebv viremia. all pediatric patients who underwent lt in norway from 2002 until 2015 were reviewed. twenty-two of 38 patients with viremia were treated with intravenous ganciclovir for a median of 22 (21-38) days. treated and untreated patients were not different with respect to ebv seroconversion prior to transplantation or age at t ...201728653462
extranodal natural killer/t-cell lymphoma: an incidental finding.extranodal natural killer/t-cell lymphoma (enktcl) is a rare form of non-hodgkin lymphoma. this neoplasm is more prevalent in regions of asia and latin america and most commonly involves the sinonasal tract, presenting with signs of nasal obstruction, epistaxis, or sinus infection. it is a locally destructive and angioinvasive neoplasm. the treatment of enktcl is dependent on the extent of the tumor. for localized disease, the treatment is chemoradiation. for disseminated disease, treatment is m ...201728652944
correlation between infection status of epstein-barr virus and (18)f-fluorodeoxyglucose uptake in patients with advanced gastric cancer.epstein-barr virus-associated gastric cancer (ebvagc) is one of the four molecular subtypes of gastric cancer, as defined by the classification recently proposed by the cancer genome atlas. we evaluated the correlation between ebv positivity and (18)f-fluorodeoxyglucose ((18)f-fdg) uptake by positron emission tomography/computed tomography (pet/ct) in patients with gastric cancer.201728652452
primary gastric alk-negative ebv-negative anaplastic large cell lymphoma presenting with iron deficiency anemia.anaplastic large cell lymphoma (alcl) is a rare subtype of non-hodgkin lymphoma (nhl). primary gastric anaplastic lymphoma kinase (alk) negative alcl is extremely rare. diagnosis of primary gastric alk-negative alcl is difficult to establish and prognosis is worse than alk-positive alcl. here, we report a case of an 82-year-old man with a history of cerebrovascular disease presented with weakness and iron deficiency anemia. he denied any abdominal discomforts. the esophagogastroduodenoscopy reve ...201728652442
[mycosis fungoides in a heart transplant recipient].skin cancer occurs frequently in organ transplant patients as a result of induced immunosuppression. most cases involve carcinomas or b-cell lymphomas induced by the epstein barr virus (ebv). cutaneous t-cell lymphomas remain rare. we report a case of cutaneous t-cell lymphoma of the mycosis fungoides type in a heart transplant recipient.201728648516
epstein-barr viral loads do not predict post-transplant lymphoproliferative disorder in pediatric lung transplant recipients: a multicenter prospective cohort study.prediction of ptld after pediatric lung transplant remains difficult. use of ebv vl in wb has been poorly predictive, while measurement of vl in bal fluid has been suggested to have enhanced utility. the nih-sponsored clinical trials in organ transplantation in children (ctotc-03) prospectively obtained serial quantitative measurements of ebv pcr in both wb and bal fluid after pediatric lung transplantation. descriptive statistics, contingency analyses, and kaplan-meier analyses evaluated possib ...201728639398
response and survival benefit with chemoimmunotherapy in epstein-barr virus-positive diffuse large b-cell lymphoma.epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) is a haematologic malignancy with poor prognosis when treated with chemotherapy. we evaluated response and survival benefits of chemoimmunotherapy in ebv-positive dlbcl patients. a total of 117 dlbcl patients were included in our retrospective analysis; 33 were ebv-positive (17 treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone [r-chop] and 16 with chop), and 84 were ebv-negative (all treated ...201728639256
spontaneous regression of epstein-barr virus-associated lymphoproliferative disorder in a juvenile idiopathic arthritis patient after the discontinuation of methotrexate and etanercept.a case of a 16-year-old female with polyarticular juvenile idiopathic arthritis (jia) since the age of 4 years is reported here. this patient also suffered from multiple congenital anomalies. on long-term treatment with oral methotrexate (mtx) and etanercept, multiple subcutaneous nodules were detected, which were accompanied by increased lactate dehydrogenase and uric acid levels. a biopsy of the largest nodule revealed epstein-barr (eb) virus-positive diffuse large b-cell lymphoma (dlbcl). the ...201728638688
environmental factors influencing multiple sclerosis in latin is generally accepted that autoimmune diseases like multiple sclerosis (ms) arise from complex interactions between genetic susceptibility and environmental factors. genetic variants confer predisposition to develop ms, but cannot be therapeutically modified. on the other hand, several studies have shown that different lifestyle and environmental factors influence disease development, as well as activity levels and progression. unlike genetic risk factors, these can be modified, with potentia ...201728638627
genome-wide analysis of 18 epstein-barr viruses isolated from primary nasopharyngeal carcinoma biopsy specimens.epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus that is highly prevalent in almost all human populations and is associated with many human cancers, such as nasopharyngeal carcinoma (npc), hodgkin's disease, and gastric carcinoma. however, in these ebv-associated cancers, only npc exhibits remarkable ethnic and geographic distribution. we hypothesized that ebv genomic variations might contribute to the pathogenesis of different human cancers in different geographic areas. in this study, ...201728637758
arsenic trioxide inhibits ebv reactivation and promotes cell death in ebv-positive lymphoma cells.epstein-barr virus (ebv) is associated with hematopoietic malignancies, such as burkitt's lymphoma, post-transplantation lymphoproliferative disorder, and diffuse large b-cell lymphoma. the current approach for ebv-associated lymphoma involves chemotherapy to eradicate cancer cells, however, normal cells may be injured and organ dysfunction may occur with currently employed regimens. this research is focused on employing arsenic trioxide (ato) as ebv-specific cancer therapy takes advantage of th ...201728637474
effects of type 1 diabetes risk alleles on immune cell gene expression.genetic studies have identified 61 variants associated with the risk of developing type 1 diabetes (t1d). the functions of most of the non-hla (human leukocyte antigen) genetic variants remain unknown. we found that only 16 of these risk variants could potentially be linked to a protein-coding change. therefore, we investigated whether these variants affected susceptibility by regulating changes in gene expression. to do so, we examined whole transcriptome profiles of 600 samples from the type 1 ...201728635624
[braf-positive paucicellular variant of anaplastic carcinoma in the presence of tall cell variant papillary thyroid cancer].to paper describes a case of paucicellular anaplastic cancer in the presence of tall cell variant papillary thyroid carcinoma. microscopic examination showed that the differentiated component of the tumor was composed of papillary structures with tall cells, the height of which exceeded 3-4 times the width. its anaplastic component consisted of fibrous tissue with occasional spindle-shaped cells and focal lymphocytic infiltration to the extent of 70%. the spindle-shaped cells expressed cytokerat ...201728631713
immunotherapy for transplantation-associated viral infections.cytomegalovirus (cmv) and epstein-barr virus (ebv) infections following allogeneic hematopoietic stem cell transplantation (hsct) are a major cause of morbidity and mortality. early clinical trials demonstrate that adoptive transfer of donor-derived virus-specific t cells to restore virus-specific immunity is an effective strategy to control cmv and ebv infection after hsct, conferring protection in 70%-90% of patients. the field has evolved rapidly to develop solutions to some of the manufactur ...201728628043
a rare case of three distinct epstein-barr virus associated lymphoproliferative disorders over sixteen years of human immunodeficiency virus infection.epstein barr virus (ebv) is well known to cause different types of malignancies. in immunocompromised patients, such as those infected with human immunodeficiency virus (hiv), there is a higher likelihood of ebv related malignant transformation. diagnosis of ebv related malignancies may be difficult and sometimes requires clinical and pathological correlation. it is very rare to have more than one type of ebv related malignancy in a single patient. until now, there are no specific guidelines for ...201728626541
phenotypic and functional characterization of t cells in white matter lesions of multiple sclerosis patients.t cells are considered pivotal in the pathology of multiple sclerosis (ms), but their function and antigen specificity are unknown. to unravel the role of t cells in ms pathology, we performed a comprehensive analysis on t cells recovered from paired blood, cerebrospinal fluid (csf), normal-appearing white matter (nawm) and white matter lesions (wml) from 27 ms patients with advanced disease shortly after death. the differentiation status of t cells in these compartments was determined by ex viv ...201728624961
aggressive natural killer cell leukemia or extranodal nk/t cell lymphoma? a case with nasal involvement.aggressive natural killer cell leukemia/lymphoma (ankl) is a rare and highly aggressive nk cell neoplasm with a short clinical course and poor prognosis and is often misdiagnosed and confused with nk/t cell lymphoma (nktl), which has a very different prognosis. here, we present a case with nasal and bone marrow involvement, provide a literature review and make a differential diagnosis.201728623913
primary progressive multiple sclerosis: putting together the puzzle.the focus of multiple sclerosis research has recently turned to the relatively rare and clearly more challenging condition of primary progressive multiple sclerosis (ppms). many risk factors such as genetic susceptibility, age, and epstein-barr virus (ebv) infection may interdepend on various levels, causing a complex pathophysiological cascade. variable pathological mechanisms drive disease progression, including inflammation-associated axonal loss, continuous activation of central nervous syst ...201728620346
vitamin d and multiple sclerosis: an update.the most recent findings linking exposure to sun and vitamin d insufficiency to multiple sclerosis (ms) are reviewed. due to insufficient sunshine and changing lifestyles, hypovitaminosis d is widespread in temperate countries. numerous epidemiological studies have strongly suggested that sunshine and vitamin d insufficiency contributes to ms risk in these countries. moreover, several large genetic studies in ms patients have recently stated unequivocally that diverse abnormalities involving vit ...201728619429
hypoxia-inducible factor-1α plays roles in epstein-barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early bzlf1 gene promoter.when confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (hif-αs). we report here that hif-1α also regulates the life cycle of epstein-barr virus (ebv). incubation of ebv-positive gastric carcinoma ags-akata and snu-719 and burkitt lymphoma sal and kemiii cell lines with a prolyl hydroxylase inhibitor, l-mimosine or deferoxamine, or the neddylation inhibitor mln49 ...201728617871
looking into enteric virome in patients with ibd: defining guilty or innocence?although there is some evidence suggesting that certain viruses may be involved in the onset of inflammatory bowel disease (ibd), data regarding viral prevalence and viral load in blood and mucosa of patients with ibd are scarce. the main aim of this study is to evaluate the prevalence and viral load of common epstein-barr virus (ebv), cytomegalovirus (cmv), and human herpes virus 6 in blood and mucosa of adult patients with endoscopic active ibd.201728617757
epstein-barr virus-induced gene 2 and leukocyte airway recruitment in response to allergen challenge. 201728617082
diagnostic algorithm for relapsing acquired demyelinating syndromes in establish whether children with relapsing acquired demyelinating syndromes (rds) and myelin oligodendrocyte glycoprotein antibodies (mog-ab) show distinctive clinical and radiologic features and to generate a diagnostic algorithm for the main rds for clinical use.201728615429
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