Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| human studies following models of tumorigenesis by dna tumor viruses in animals. | the discovery of virus-specific messenger rna in virus-induced animal tumors has led to the search for messenger rna in human tumors that can be hybridized with the dna of known oncogenic viruses. attention has focused on the adenoviruses, which have produced cancer in laboratory animals and are widespread in man, and on three papovaviruses that have been isolated in human disease and which are oncogenic in hamsters. in other research, the association between human infection with herpesivurs typ ... | 1978 | 208690 |
| production of migration inhibitory factor (mif) by human leukocytes following exposure to epstein-barr virus. | 1978 | 208782 | |
| expression of altered ribonucleotide reductase activity associated with the replication of the epstein-barr virus. | 1978 | 210572 | |
| stimulation of peripheral human lymphocytes by autologous ebv genome-carrying lymphoblastoid cell lines. | 1978 | 208783 | |
| persisting oncogenic herpesvirus induced by the tumour promotor tpa. | 1978 | 204874 | |
| [infectious mononucleosis. 6. infectious mononucleosis with thrombocytopenia]. | 1978 | 205051 | |
| [adenomegalic cytophagic sinusal histiocytosis. morphological and immunologic study of a case]. | the case of a 14-year-old boy of north-african origin, presenting a phagocytic sinus histiocytosis is reported. the main features of this now classical disease are illustrated: its localization to the neck, its chronicity, the fact that it is well tolerated, the pseudotumoral appearance of the adenomegaly as well as the intensive phagocytic (essentially lymphocytophagic) activity of the sinus macrophages. the bringing to light in a picture of hyperimmunity of an elevated percentage of antibodies ... | 1978 | 205185 |
| factors affecting serum iga antibody to epstein-barr viral capsid antigens in nasopharyngeal carcinoma. | irrespective of the ethnic origin of the patient, nasopharyngeal carcinoma (npc), appears to stimulate the production of iga antibodies against vca. these antibodies are detected at high frequency and titres in sera from npc patients but only rarely from control subjects. a majority of relapse-free survivors tested 1-12 years after radiotherapy (rt) sustain a detectable level of iga anti-vca. serum titres of iga anti-vca remain relatively unchaged in individual npc patients after rt, regardless ... | 1978 | 205232 |
| an immunologic basis for detection of occult primary malignancies of the head and neck. | after extensive evaluation of patients with metastatic neck disease and clinically undetectable primary cancer of the head and neck, the clinician is often faced with the difficult question of subsequent management. in this study, sera from 11 patients with clinically occult carcinoma and metastatic lymphadenopathy were studied for epstein-barr virus-associated antigens. these were compared with 35 sera from patients with known nasopharyngeal carcinoma at all stages of disease and treatment and ... | 1978 | 205337 |
| the detection of epstein barr virus antibody in 'exanthematic' dermatoses with special reference to pityriasis lichenoides. a preliminary survey. | 1978 | 206394 | |
| lymphoblastoid cell lines from sarcoid patients. | 1978 | 206399 | |
| ocular granulocytic sarcoma (chloroma) with acute myelomonocytic leukemia in turkish children. | in a series of 166 leukemic children from turkey, 56 had acute myelomonocytic leukemia (amml). seventeen boys and 3 girls presented with chloroma-like deposits (granulocytic or myeloid sarcomas) in the eye and orbit, all showing amml on initial study of blood and marrow. the ocular lesions responded rapidly to antileukemic therapy. laboratory studies of amml cases revealed no cytogenetic or immune defects, and epstein-barr virus titers were normal. a group-specific (gs-3) antigen (type-c virus?) ... | 1978 | 205341 |
| characterization of a unique cell line (laz 221) from human acute lymphocytic ("null" cell) leukemia. | a unique human cell line designated laz 221 has been established from the peripheral blood of a patient with acute lymphocytic leukemia of the "null" cell type. the cell line does not possess the epstein-barr virus nuclear antigen and has a karyotype of 45,xx,-9,-12,+(9q12q). both the established cell line and the patient's uncultured blast cells share the same phenotypic markers. they both lack t-cell markers. they fail to form sheep erythrocyte rosettes and do not react with t-cell-specific an ... | 1978 | 205365 |
| epstein-barr virus-determined nuclear antigen in malignant epithelial cells of nasopharyngeal carcinoma. | tumor tissue from lymph node metastasis of nasopharyngeal carcinoma (npc) was successfully heterotransplanted into an athymic nude mouse and the tumor grown in the nude mouse was identical in its morphology to that form the patient by optical and electron microscopy. tumor cells at passage 2 were dispersed in vitro by enzymic digestion and smeared. epstein-barr virus-determined nuclear antigen (ebna) was demonstrated in malignant epithelial cells of the smear. | 1978 | 205477 |
| expression of an antigen associated with acute lymphoblastic leukemia in human leukemia-lymphoma cell lines. | 1978 | 206705 | |
| [hepatology and immunology]. | immunologic diseases of the liver are exogenous mostly initiated by virus or endogenous initiated by autoaggression. all virus-induced kinds of hepatitis are due to an immune response against inocculated hepatocytes. therefore the hepatitis is limited to the period of complete elimination of virus-infected cells. a strong immune response therefore corresponds with an acute and short hepatitis whilest a weak immune response develops a chronic hepatitis. in contrast, autoimmune hepatitis based on ... | 1978 | 205495 |
| heterophil antigen in bovine sera detectable by immune adherence hemagglutination with infectious mononucleosis sera. | bovine sera for tissue culture use were shown to contain heterophil antigen of the paul-bunnell-davidsohn type by immune adherence hemagglutination tests with sera from patients with infectious mononucleosis. the antibody titers observed were comparable to those determined by two other methods; i.e., the immune adherence hemagglutination test was found to be as specific as the differential absorption test with horse erythrocytes or the ox cell hemolysis assay,but it appeared to be the most sensi ... | 1978 | 205510 |
| studies on cytotoxicity generated in human mixed lymphocyte cultures. i. time course and target spectrum of several distinct concomitant cytotoxic activities. | 1978 | 205612 | |
| epstein-barr virus-immune complexes in postmortem kidneys from african patients with burkitt's lymphoma and american patients with and without lymphoma. | 1978 | 205665 | |
| state of epstein-barr virus dna in an american burkitt's lymphoma line. | a human lymphoma cell line, positive for the epstein-barr virus (ebv)-associated nuclear antigen, was recently established from a north american burkitt's lymphoma. this cell line, su-amb-2, contained ebv dna both in the form of circular, nonintegrated dna molecules of viral genome length, present in multiple copies per cell, and as integrated sequences. having dna present in both of these forms, it resembled cell lines established from african burkitt's lymphomas. in studies on ebv strain diffe ... | 1978 | 205666 |
| integrated viral dna sequences in epstein-barr virus-converted human lymphoma lines. | most human lymphoid cell lines contain multiple copies of circular, nonintegrated epstein-barr virus (ebv) dna molecules as well as viral dna sequences with properties of integrated dna. the physical state of the ebv dna in a human lymphoma line that only contains one virus genome equivalent per cell has now been studied by three different methods, neutral cscl density gradient centrifugation, actinomycin d-cscl gradient centrifugation, and hirt fractionation. this cell line, aw-ramos, has been ... | 1978 | 205668 |
| a new tumour-derived transforming strain of epstein-barr virus. | 1978 | 205793 | |
| epstein-barr virus is not synonymous with infectious mononucleosis. | 1978 | 205830 | |
| differences in expression of surface marker characteristics on epstein-barr virus-transformed human and simian lymphoid cell lines. | human lymphoblastoid cell lines transformed in vitro by the epstein-barr virus (ebv) had receptors for fixed complement detectable by a rosette test. ebv transformed cells derived from cotton-topped marmoset leukocytes did not express this receptor. evidence is presented that both human and marmoset cell lines arose from precursor cells which have complement receptors. our findings suggest that transformation of marmoset leukocytes by ebv results in the loss of a differentiated surface marker. | 1978 | 205852 |
| characteristics of cell lines established from epstein-barr virus induced marmoset tumors. | the inoculation of a cotton-topped marmoset with b95-8 strain of ebv resulted in the induction of a multifocal lymphoma and lymphoblastoid cell lines were established from liver, spleen and mesenteric lymph node tumors. the cell lines were remarkably similar to each other with respect to the presence of ebv and its expression, the surface properties of the cells and their stability, and the functional products of the cells. karyotypic examination of the cell lines revealed the common loss of a s ... | 1978 | 205853 |
| susceptibility of marmosets to epstein-barr virus-like baboon herpesviruses. | epstein-barr virus (ebv)-like herpeviruses, strains of herpesvirus papio (hvp), have recently been isolated from lymphomatous (hvp-l) and from normal baboons (hvp-n). both hvp isolates infect some species of marmosets, hvp-l inoculated adult animals develop a mild to severe and sometimes fatal lymphoproliferative disease whereas newborn marmosets of the same species do not develop a measureable disease after inoculation with hvp-l. hvp-n infects adult marmosets but does not cause disease. | 1978 | 205854 |
| reversible inhibition by phosphonoacetic acid of human b lymphocyte transformation by epstein-barr virus. | 1978 | 208257 | |
| mechanisms of infection with epstein-barr virus. iii. the synthesis of proteins in superinfected raji cells. | 1978 | 208266 | |
| overview of viral oncology studies in saguinus and callithrix species. | marmoset monkeys are highly susceptible to tumor induction by type c sarcoma viruses and primate lymphotropic herpeviruses. six experimental models were reviewed, three sarcoma models induced by rous, feline or simian sarcoma viruses and three models of lymphoproliferative disease induced by herpevirus saimiri, h. ateles or epstein-barr virus. relative susceptibility of cotton-topped (saguinus oedipus oedipus), white-lipped (s. nigricollis, s. fuscicollis subspecies) and commone (callithrix jacc ... | 1978 | 205860 |
| transforming activity of epstein-barr virus obtained by superinfection of raji cells. | epstein-barr virus obtained by superinfection of raji cells with epstein-barr virus recovered from p3hr1 cells (hri virus) transformed human lymphocytes, but it did not superinfect raji cells. a human lymphoblastoid cell line, hlb, established by such transformation contained 22 epstein-barr virus genomes per cell and epstein-barr virus-associated nuclear antigen, and a few cells contained early or viral capsid antigen complexes. chromosomal analysis revealed that hlb-cells were diploid with nor ... | 1978 | 205877 |
| nasopharyngeal carcinoma. | 1978 | 205903 | |
| the immunological approach to study of possibly virus-induced human malignancies using the epstein-barr virus as example. | 1978 | 205906 | |
| an assessment of the possible role of viruses in the aetiology of burkitt's lymphoma. | 1978 | 205908 | |
| establishment of paired tumor cells and autologous virus-transformed cell lines to define humoral immune responses in melanoma and sarcoma patients. | peripheral blood lymphocytes and skin fibroblasts from 12 cancer patients were infected with epstein-barr virus (ebv) or sv40 virus. the ebv-transformed lymphoblasts and sv40-transformed fibroblasts were grown as continuous cell lines and expressed the same histocompatibility antigens as tumor cell lines established from the same cancer patients. sera from 350 melanoma and 195 sarcoma patients were tested for antibody reactive with membrane antigens on three of these tumor cell lines (two melano ... | 1978 | 204583 |
| autoradiographic detection of epstein-barr virus (ebv)-associated early antigen in a variety of ebv dna-containing lymphoblastoid cell lines previously designated as nonproducers. | by using autoradiography combined with 125i-labeled igg prepared from human sera containing high anti-ea (early antigen) antibody titers, ea has been detected in a low fraction of cells in a variety of ebv dna-containing cell lines previously designated as negative for this antigen. these positive cell lines are highly inducible for ea following treatment with iododeoxyuridine (iudr) and also contain multiple copies of the virus genome on average. the correlation between iudr inducibility and sp ... | 1978 | 204604 |
| partial purification and properties of the epstein-barr virus-associated nuclear antigen. | the epstein-barr virus (ebv)-associated nuclear antigen (ebna) was purified 85-fold from a nuclear pellet derived from an ebv-transformed b lyphoblastoid cell line by a five-step procedure consisting of preparation of extract, heating at 80 degrees c in phosphate buffer, ammonium sulfate precipitation, preparative ultracentrifugation, and affinity chromatography on double-stranded dna-cellulose. the purified complement fixing antigen specifically blocked the anticomplement immunofluorescence ass ... | 1978 | 204660 |
| laboratory diagnosis of eb virus infection in some cases presenting as hepatitis. | in 1975 and 1976, 7580 serum specimens were tested for hbsag by the passive haemagglutination test, hepanosticon. serum from 38 people gave a positive result after absorption with the absorbent provided, but the presence of hbsag could not be confirmed by other tests. tests for current infection with eb virus, namely, the presence of heterophil antibody and eb virus specific igm, were performed and were positive in 11 of the 38. in six of these the clinical picture was of hepatitis rather than i ... | 1978 | 204666 |
| production of antibody to tetanus toxoid by continuous human lymphoblastoid cell lines. | peripheral lymphocytes from human volunteers boosted with tetanus toxoid were cultured after in vitro infection with epstein-barr virus. forty-four continuous lymphoblastoid lines were established which continued to secrete human gamma globulin; seven of these secreted antibody to tetanus toxoid. subcultures derived from limiting dilution experiments continued to secrete the antibody. some of these antibody-secreting cells have been in continuous culture for more than 6 months. | 1978 | 204013 |
| latent characteristics of selected herpesviruses. | 1978 | 204166 | |
| immune function in healthy relatives of patients with malignant disease. | immune function studies of healthy members of families with multiple lymphoreticular neoplasms were compared with those of healthy members of families with multiple cancers and families with no known history of cancer. the lymphoma family group had a significantly elevated serum level of igm and diminished responses to the candida albicans skin test antigen and the t-cell mitogen concanavalin a. subjects with epstein-barr virus-viral capsid antigen titers greater than or equal to 160 had lower r ... | 1978 | 203705 |
| epstein-barr virus-associated and other antiviral antibodies during intense bcg administration to patients with burkitt's lymphoma in remission. | patients with burkitt's lymphoma in chemotherapy-induced remission received through dermal scarifications one or two doses per week of approximately 3 x 10(8) living bcg organisms (pasteur institute vaccine). this treatment was always followed by usually rapid increases by 1--4 log2 steps in the antibody titers to epstein-barr virus (ebv)-associated cell membrane antigens. titer increases of less than 2.5 log2 steps within the first month after the start of bcg treatment correlated with a signif ... | 1978 | 203706 |
| comparative studies on the induction of virus-associated nuclear antigen and early antigen by lymphocyte-transforming (b95-8) and nontransforming (p3hr-1) strains of epstein-barr virus. | 1978 | 201584 | |
| induction of ebna precedes the first cellular s-phase after ebv-infection of human lymphocytes. | using a combination of immunofluorescence and autoradiography, we studied the appearance of ebna and dna synthesis in cord-blood lymphocytes after infection with ebv derived from the b95-8 cell line. ebna appeared between 12 and 25 h after addition of the virus. dna synthesis was detected in ebna-positive cells approximately 20 h after the appearance of ebna. this shows that ebna induction precedes the first cellular s-phase and suggests that the cells have not yet entered the cell-division cycl ... | 1978 | 203544 |
| infectious mononucleosis and the epstein-barr virus. | recent elucidation of the relationship between the epstein-barr virus and infectious mononucleosis has resulted in the development of new diagnostic serological tests, and has amplified our knowledge of the epidemiological and clinical aspects of the disease. the history, epidemiology, clinical characteristics, diagnostic features, and therapy of infectious mononucleosis are reviewed. this is done in the light of recent knowledge concerning the epstein-barr virus as well as previous studies empl ... | 1978 | 203184 |
| tonsillectomy and infectious mononucleosis. | tonsillar tissue may be the primary site of infection with epstein-barr virus (ebv), the etiologic agent of classical infectious mononucleosis (im). therefore, a retrospective study of the association between tonsillectomy and im was performed in a college student population. in the first part of the study, tonsillectomy rates were compared between 164 im-positive students and 164 student controls who attended ucla in 1972-1975. although it was determined that the development of im during colleg ... | 1978 | 203187 |
| properties of epstein-barr virus transformed woolly monkey lymphoblastoid cell lines. | 1978 | 204945 | |
| large-scale production and concentration of infectious epstein-barr virus. | infectious epstein-barr virus (ebv) was produced from suspension cultures of p3hr-1 cells. a protocol for the scaled-up production and concentration of the virus was developed. virus from the culture fluid was concentrated by continuous-flow pelletization or continuous flow with banding in sucrose. ebv prepared by pelletization yielded 1.7 x 10(4) infectious units/ml (100 x concentration) and less than 3.4 x 10(7) evb particles/ml (1,000 x concentration), whereas ebv prepared by banding yielded ... | 1978 | 203227 |
| a new lymphoid cell line, reh 6, with characteristics of non-t and non-b cells, lacking the epstein-barr virus genome and derived from human acute lymphoblastic leukemia. | a new lymphoid cell line, reh 6, has been established from the peripheral blood of a patient with acute lymphocytic leukemia. reh 6 cells were assayed for the presence of epstein-barr virus (ebv) dna by nucleic acid hybridization and for epstein-barr nuclear antigen (ebna) by the immunofluorescence test. reassociation kinetics between in vitro [3h]-labeled ebv dna and reh 6 cell dna indicated the absence of detectable amounts of ebv dna in reh 6 cell dna. in addition, attempts to detect ebna by ... | 1978 | 202576 |
| appearance of early and late components of epstein-barr virus-associated membrane antigen in daudi cells superinfected with p3hr-1 virus. | this study investigated the synthesis of membrane antigen (ma) as well as virus capsid antigen (vca) and early antigen (ea) in daudi cells which had been superinfected with the p3hr-1 strain of epstein-barr virus (ebv) and then treated with trypsin to remove initially absorbed ma-positive material from the cell surface. synthesis of ma, vca and ea was completely inhibited by puromycin. a marked reduction in the frequency of ma positive cells was observed in superinfected cells cultured in the pr ... | 1978 | 202665 |
| cytofluorometry of lymphocytes infected with epstein-barr virus: effect of phosphonoacetic acid on nucleic acid. | dna synthesis in epstein-barr virus (ebv)-infected lymphocytes was inhibited by phosphonoacetic acid (paa) as measured by [3h]thymidine incorporation. paa, at a concentration of 200 microgram/ml, inhibited [3h]thymidine incorporation by human umbilical cord lymphocytes infected with ebv strain p94 but had little effect on dna synthesis in mitogen-stimulated cells. transformed cell lines did not develop from infected cord cell cultures treated with 100 microgram of paa per ml. cytofluorometric an ... | 1978 | 202732 |
| radiobiological inactivation of epstein-barr virus. | lymphocyte transforming properties of b95-8 strain epstein-barr virus (ebv) are very sensitive to inactivation by either uv or x irradiation. no dose of irradiation increases the transforming capacity of ebv. the x-ray dose needed for inactivation of ebv transformation (dose that results in 37% survival, 60,000 rads) is similar to the dose required for inactivation of plaque formation by herpes simplex virus type 1 (fischer strain). although herpes simplex virus is more sensitive than ebv to uv ... | 1978 | 202757 |
| epstein-barr virus and burkitt's lymphoma. | 1978 | 202872 | |
| epstein-barr virus infection of cryopreserved umbilical cord blood lymphocytes. | 1978 | 202978 | |
| oropharyngeal excretion of epstein-barr virus by patients with lymphoproliferative disorders and by recipients of renal homografts. | in an attempt to associate oropharyngeal excretion of epstein-barr (eb) virus with lymphoproliferative disorders other than infectious mononucleosis, we tested throat gargles collected from adult subjects for the eb virus. nine (16%) of 55 healthy persons were positive. high eb virus-excretion rates were found among patients with active acute lymphocytic leukemia (6/6, 100%), among renal homograft recipients during the third to 12th month after transplantation (26/30, 87%), and among critically ... | 1978 | 202183 |
| gut lymphoma presenting simultaneously in two siblings. | 1978 | 202368 | |
| a convenient method of establishing permanent lines of xeroderma pigmentosum cells. | nine lymphoblastoid cell lines were established after transformation by epstein-barr virus of peripheral lymphocytes from four xeroderma pigmentosum (xp) patients, the parents of one xp patient, and three normal donors. all these cell lines proliferate as suspension in roswell park memorial institute medium 1640 supplemented with 20% fetal bovine serum, without detectable release of infectious epstein-barr virus. some characteristics of these cell lines, such as growth rates, chromosome numbers, ... | 1978 | 202381 |
| epstein-barr virus (ebv) receptors, complement receptors, and ebv infectibility of different lymphocyte fractions of human peripheral blood. ii. epstein-barr virus studies. | 1978 | 202404 | |
| two e-rosette-forming lymphoid cell lines. | two e-rosette (spontaneous rosette with sheep red blood cells)-forming lymphoid cell lines were established. one (hpb-all) was derived from a young male japanese patient with acute lymphoblastic leukemia (all), and the other (hpb-mlt) was from a 62-year-old female japanese patient with a leukemic t-lymphoid malignancy. formation of e rosettes, absence of any immunoglobulin determinants, absence of ebna (epstein-barr virus associated nuclear antigen) and very limited stimulating ability in mixed ... | 1978 | 203546 |
| virological aspects of head and neck cancer. | 1978 | 201814 | |
| epstein-barr-virus immunity and tissue distribution in a fatal case of infectious mononucleosis. | 1978 | 201839 | |
| inhibition by phosphonoacetate of the in vitro outgrowth of epstein-barr virus genome-containing cell lines from the blood of infectious mononucleosis patients. | 1978 | 221394 | |
| [infantile cortical hyperostosis. description of a case with positive paul-bunnell-davidsohn reaction]. | 1978 | 224298 | |
| immunovirologic assessment of american patients with nasopharyngeal carcinoma and occult primary tumors. | the epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma, suggesting an etiologic relationship. we have under-taken studies (1) to quantitate the relationship between antibody titers to ebv-associated antigens and nasopharyngeal carcinoma in american patients since most of the patients in previous studies were of either asian or african descent and (2) to determine the relationship between antibody titers and the clinical course of the disease. sera from patients with pri ... | 1978 | 224361 |
| surface markers and functional characteristics of human blood lymphocytes residing in the operational "null" subset. | after removal of nylon wool-adherent b and e rosetting t cells from the human blood lymphocyte population, a small fraction remains, often denoted as "null" subset. this fraction contains lymphocytes which are highly efficient in antibody-dependent and non-selective lymphocyte cytotoxicity. these cells possess markers. about half of them carry fc receptors, and the majority has low avidity e and c3 receptors. removal of low avidity e receptor-carrying cells did not abolish cytotoxicity to k-562 ... | 1978 | 231548 |
| cancer, viruses and environmental factors. | the genesis of burkitt's lymphoma is visualized as proceeding in three steps: i. primary ebv infection affects the young child, probably at a relatively high multiplicity. it immortalizes a certain number of b-lymphocytes in vivo. ii. this is followed by the impact of an environmental promoting agent, perhaps chronic holoendemic malaria, providing a chronic stimulus to the proliferation of the ebv-carrying preneoplastic cells. iii. chromosomally abnormal variants appear in the stimulated tissue ... | 1978 | 231549 |
| ebv specific killer t cells and serologic responses after onset of infectious mononucleosis. | 1978 | 228038 | |
| detection of epstein-barr virus-coded antigens in lymphocytes isolated from defined patient samples. | a preliminary report on the use of specific rabbit antisera raised to epstein-barr virus-coded antigens (ebna and ea) for detection of these antigens in vivo is presented. human lymphocytes were isolated on isokinetic gradients and the c3 receptor-bearing b-lymphocyte subpopulation was isolated, providing an enriched source of ebv-infected lymphocytes. such technology was employed to establish the status of the ebv host-cell complex in recurrent exudative tonsillitis (ret), infectious mononucleo ... | 1978 | 221395 |
| epstein-barr virus nuclear antigen (ebna)-positive cells in a lymph-node of a child with severe primary ebv infection. | 1978 | 221396 | |
| replication of epstein-barr virus dna in epithelial cells in vivo. | epstein-barr virus (ebv)-specific complementary rna (crna) was hybridized in situ to oropharyngeal epithelial cells taken from patients with infectious mononucleosis. cells from patients shedding virus in the throat hybridized signifnicant quantities of crna, whereas cells from ebv-negative sources did not. the degree of hybridization indicated a large ebv genome number per infected epithelial cell and suggested that these cells were the source of virus found in the throat. this finding may expl ... | 1978 | 221397 |
| comparison of immune responses and viral markers in herpesviruses-associated carcinomas: a review. | 1978 | 221405 | |
| comparison of humoral and cell-mediated responses and virus markers in herpesvirus-associated lymphomas: a review. | 1978 | 221406 | |
| "neonatal" tumour induction: the emerging immune surveillance mechanism and amphibian embryo tumorigenesis. | 1978 | 221407 | |
| evb-associated immune complexes and recurrent burkitt's lymphoma. | 1978 | 221409 | |
| iga and nasopharyngeal carcinoma. | 1978 | 221410 | |
| evaluation of delayed hypersensitivity reactions to lymphoid cell lines and antibodies to epstein-barr virus. | 1978 | 221411 | |
| demonstration of ebna (epstein-barr virus nuclear antigen) antibodies of different immunoglobulin classes. | anit-ebna igm, a previously unknown antibody, was detected by the antihuman globulin anticomplement immunofluorescence (acif) method in serum samples from acute infectious mononucleosis (im) of epstein-barr virus (ebv) origin. the antibody disappears from the serum in some weeks during convalescence. it was absent in anti-ebv=positive sera of healthy donors and in serum samples taken from patients with im caused by cytomegalo-virus. the antibody appears simultaneously with anti-ebv igmm and, rea ... | 1978 | 224651 |
| immunodeficiency to the epstein-barr virus in the x-linked recessive lymphoproliferative syndrome. | 1978 | 201410 | |
| papain solubilization of the epstein-barr virus-induced membrane antigen. | the epstein-barr virus (ebv)-induced membrane antigen (ma) was successfully solubilized from the membranes of viable ebv-infected raji cells by treatment with papain (5 to 6 u per 1 x 10(7) to 2 x 10(7) cells). the loss of ma from viable cells was monitored by membrane immunofluorescence and antibody-dependent cellular cytotoxicity. soluble ma was demonstrated in papain digests through inhibition of antibody-dependent cellular cytotoxicity and by inhibition of the binding of anti-ma antibodies t ... | 1978 | 81320 |
| epstein-barr antibodies in suspected nasopharyngeal carcinoma. | 1978 | 82106 | |
| epstein-barr virus d.n.a. in tumour tissue from native alaskan patients with nasopharyngeal carcinoma. | 1978 | 82107 | |
| epstein-barr-specific iga in nasopharyngeal cancer. | 1978 | 78104 | |
| limited immunodeficiency. | 1978 | 87559 | |
| observations on cell lines derived from a patient with hodgkin's disease. | permanent cell lines have been established from a spleen nodule and lymph node of a male hodgkin's disease (hd) patient whose father has the same disease. th in vitro growth pattern morphological and cytogenetic characteristics of these lines maintained continuously for over 2 years are described. the cultures contain a population of mixed cell types that grow in suspension. between 5 and 10% of the cells have surface immunoglobulins m and d. b-cell alloantigens are also detectable. while the cu ... | 1978 | 78764 |
| colonies of ebna-positive cells in soft agar from peripheral leukocytes of infectious mononucleosis patients. | epstein-barr virus (ebv)-associated nuclear antigen (ebna)-positive lymphoblastoid cells grew as colonies in soft agar after seeding of leukocytes from the peripheral blood of four patients with infectious mononucleosis serologically determined to be caused by ebv. in individual cases more colonies were obtained from blood specimens during the acute phase of the disease than during the convalescent phase. incorporation of human umbilical cord serum, which contained neutralizing antibody to ebv, ... | 1978 | 78908 |
| ebv antigens in lymphocytes of patients with exudative tonsillitis, infectious mononucleosis and hodgkin's disease. | a protocol utilizing isokinetic gradients to isolate human lymphocytes is combined with another that purifies the c3 receptor-bearing b lymphocyte subpopulation, thus enriching the eb virus genome-carrying population. also, rabbit antisera were prepared to the epstein-bar virus nuclear antigen (ebna) and the early antigen (ea) and utilized in an indirect immunofluorescence test (iit) to detect these antigens in human lymphocytes isolated from various disease states. using these methods we demons ... | 1978 | 78913 |
| persistent epstein-barr virus infection in a child with hypergammaglobulinaemia and immunoblastic proliferation associated with a selective defect in immune interferon secretion. | a 5-year-old girl had a chronic disease characterised by fever, lymphoid hyperplasia, interstitial pneumonitis, thrombocytopenia, and polyclonal hypergammaglobulinaemia. evidence for severe, persistent epstein-barr virus (e.b.v.) infection was found: titres of antibody to e.b.v. viral capsid antigen (igm and igg) and early antigen were extremely high, cells containing e.b.v.-associated nuclear antigen (e.b.n.a.) were found in lymph nodes and blood, and spontaneous permanent lymphoblastoid cell l ... | 1978 | 79029 |
| epstein-barr virus and burkitt lymphoma. | 1978 | 79925 | |
| heterogeneity of epstein-barr virus. iv. induction of a specific antigen by ebv from two transformed marmoset cell lines in ramos cells. | infection of cells of the ebv-genome-negative human b-lymphoma ramos line with viral isolates obtained from two ebv-transformed marmoset cell lines (b95/8; nyevu) resulted in the induction of a nuclear antigen (ram-ag) apparently different from other ebv-associated antigen complexes. this antigen is revealed by indirect immunofluorescence and shows no detectable cross-antigenicity with ebna or any other known ebv-associated antigen. ebv-isolates from p3hr-1 cells fail to induce a similar antigen ... | 1978 | 81181 |
| cellular immunity in infectious mononucleosis. ii. specific reactivity to epstein-barr virus antigens and correlation with clinical and hematologic parameters. | infectious mononucleosis (im) patients, epstein-barr virus (ebv)-seropositive and seronegative healthy donors, and patients with other viral infections were tested for lymphocyte blastogenesis (lb) with phytohemagglutinin and six ebv (virus concentrate, culture supernatant, and soluble [s] antigen) or control antigens. fluorescent antibodies to ebv viral capsid antigen of igg, igm, iga specificities, to nuclear antigen (ebna), and heterophile antibodies were also assayed. these were correlated w ... | 1978 | 81224 |
| a novel surface antigen on lymphoid cells transformed by epstein-barr virus. | a surface antigen (sa) was detected on ebv-carrying lymphoid cell lines by an indirect membrane immunofluorescence test with serum from rabbits immunized with raji cells; the antiserum had been extensively absorbed with normal human blood and tonsil cells. the sa was not detected on normal human umbilical-cord and adult peripheral blood lymphocytes or ebv-negative cell lines. the incidences of the sa and ebv-determined membrane antigen (ma) on certain ebv-carrying cell lines were not compatible. ... | 1978 | 87368 |
| comparison of the stimulating capacity of human leukemia t-cell, null cell, and b-cell lines in mixed lymphoma culture. | one-way mixed lymphocyte reactions between lymphocytes from normal human donors and mitomycin c-treated cells from human leukemia t-cell, null cell, and b-cell lines were investigated. an epstein-barr virus (ebv)-negative japanese burkitt's lymphoma line and two ebv-positive normal lymphoid cell lines were studied in parallei. normal lymphocytes were stimulated significantly by the cultured null cells and b-cells, but only slightly by the cultured t-cells. the stimulatory capacity of these two l ... | 1978 | 147348 |
| longitudinal study of epstein-barr virus antibody titers and excretion in pediatric patients with hodgkin's disease. | nineteen pediatric patients with hodgkin's disease (hd) who had experienced primary epstein-barr virus (ebv) before, or in one case after, diagnosis, were studied longitudinally for changes in the titers and spectra of ebv-related antibodies, excretion of ebv into the oropharynx, the number of ebv-carrying lymphoid cells in the peripheral blood, and clinical signs and symptoms suggestive of reactivation of the latent virus. the incidence and geometric mean titers of igg antibodies to viral capsi ... | 1978 | 82539 |
| study of epstein-barr virus-determined nuclear antigen (ebna) by chromatography on fixed cell nuclei. | low ionic strength (50 to 100 mm nacl) and ph 6.0 were found to be optimal conditions for in vitro conversion of epstein-barr virus (ebv)-determined nuclear antigen (ebna)-negative nuclei to ebna-positive nuclei by addition of the complement-fixing (cf) antigen extracted from raji cells. in vitro conversion of nuclei to ebna-positively was sensitive to dnase but not to rnase treatment. this suggests that nuclear dna is a specific target substance to which ebv-cf antigen binds. if nuclei were fix ... | 1978 | 82540 |
| somatic cell hybrids between human lymphoma cell lines. v. idurd inducibility and p3hr-1 superinfectability of daudi/hela (dad) and daudi/p3hr-1 (dip-1) cell lines. | we have studied two types of somatic cell hybrid with regard to expression of the epstein-barr virus (ebv) cycle and its regulation. the first, dip-1, a hybrid formed between two human lymphoma ebv producers (daudi and p3hr-1), contained ebv dna, expressed the virus-determined nuclear antigen (ebna), andwas a producer of the ebv-associated antigens ea (early antigen) and vca (viral capsid antigen). the second, dad, a hybrid series of clones formed between daudi and a hela cell derivative (d98), ... | 1978 | 82545 |
| studies on epstein-barr virus-related antigens. iii. purification of the virus-determined nuclear antigen (ebna) from non-producer raji cells. | the purification of epstein-barr virus-determined nuclear antigen (ebna) was attempted on the basis of its biochemical and physicochemical properties and its immunological specificity, assayed by the indirect single radial immunodiffusion test and anti-complement immunofluorescence absorption test. when non-producer raji cell extract was subjected to 20--60% saturated ammonium sulfate fractionation, followed by dna-cellulose chromatography and immunoadsorbent chromatography, ebna was purified mo ... | 1978 | 82547 |
| the association between undifferentiated nasopharyngeal carcinoma and epstein-barr virus shown by correlated nucleic acid hybridization and histopathological studies. | all of 51 undifferentiated carcinomas of the nasopharynx were ebv-dna-positive and, in the few tests performed, ebna-positive as well. most of these patients also had high anti-ebv [vca and ea (d)] antibody titres. of four patients that had somewhat differentiated npcs, two were ebv-dna-positive with a corresponding serological picture, whereas two were negative with an ebv serology comparable to that of healthy donors. of seven lymphomas localized in the nasopharynx, one was ebv-dna-positive an ... | 1978 | 83285 |
| non-a, non-b hepatitis. | 1978 | 77141 | |
| epstein-barr virus infections in the x-linked recessive lymphoproliferative syndrome. | prospective studies demonstrated variable phenotypic expression of the x-linked recessive lymphoproliferative syndrome (x.l.r.l.s.) in three brothers: (1) hypogammaglobulinaemia and subclinical epstein-barr-virus (e.b.v.) infection with antibody response to e.b.v.; (2) e.b.v. infection with defective immune response to e.b.v., fatal infectious mononucleosis (i.m.), and immunoblastic lymphoma; and (3) histiocytic lymphoma. hypogammaglobulinaemia and measles pneumonitis had preceded infection with ... | 1978 | 85816 |
| the simultaneous observations of immunofluorescence and cellular morphology in viral infections: a new procedure. | a simple method for comparative observations of immunofluorescence and cellular morphology has been developed in the investigation of epstein-barr virus (ebv) infection and oncogenesis. when cells were stained for immunofluorescence of ebv-determined nuclear antigen, early antigens, or the viral capsid antigen, followed by treatment with hematoxylin, viral marker expression and cellular morphology could be simultaneously observed in individual cells by simply changing ultraviolet illumination to ... | 1978 | 95789 |
| abortive growth of human lymphocytes carrying a dormant epstein-barr viral genome. | when p3hr-1 lymphoblastoid cells expressing epstein-barr virus (ebv)-related antigens at very low frequency were cocultivated with human umbilical cord blood lymphocytes and the cell-free mixed culture fluid was applied to fresh cord lymphocytes, cells morphologically distinct from normal lymphocytes became evident after one to two weeks' exposure. the abnormal cells became abundant after one month and were easily identified by b-cell markers and a variety of morphologic abnormalities. such abno ... | 1978 | 45600 |