Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [t- and b-lymphocyte determination in infectious mononucleosis]. | in 12 children with infectious mononucleosis the peripheral blood t- and b-lymphocytes were studied and compared to a control group of 26 children, aged 2 to 13 years, without any infection. spontaneous sheep red blood cell rosettes were used as a t-cell marker, demonstration of surface immunoglobulins by immunofluorescence technique was used as a b-cell marker. patients with infectious mononucleosis showed a marked increase of t-lymphocytes (percentage and absolute numbers) in comparison with t ... | 1977 | 328360 |
| [post-transfusion hepatitis 1973 and 1974 in the zürich region]. | more than 100 000 units of blood were tranfused during the years 1973-74 in the region of zurich. 30 cases of posttransfusion hepatitis (pth) reported in this period were investigated with regard to the origin of the tranfused blood, and 24 (71%) proved to be hepatitis b antigen (hbs-ag) positive. despite the use of a sensitive method for hbs-ag screening, transfusion of hbs-ag positive blood was found to be responsible for pth in 4 cases only. in 88% of the cases there was no proof that the pth ... | 1977 | 834982 |
| hematopathology and pathogenesis of the x-linked recessive lymphoproliferative syndrome. | subtle immunodeficiency to infectious agents including measles virus and ten epstein-barr virus (ebv) has been described in the x-linked recessive lymphoproliferative syndrome. this syndrome has affected six male cousins and possibly another boy. three brothers died of an infectious mononucleosis syndrome, in a maternal cousin agammaglobulinemia developed three years after infectious mononucleosis, and two half-brothers of the duncan kindred died of lymphoma of the brain and intestinal tract, re ... | 1977 | 835602 |
| a new class of infectious agents detectable by the production of chorioallantoic membrane lesions by human lymphoblastoid cell lines and their culture supernatants. | intravenous injection of cells and their tissue culture supernatants (cs) from human lymphoblastoid cell lines (lcl) induced the formation of lesions on the chorioallantoic membrane (cam) of the chicken embryo. injection of cells and cs from non-lcl and normal human lymphocytes induced few or no lesions. irradiated chick embryos were more sensitive to lesion formation than were nonirradiated embryos. the log10 cam lesions induced in irradiated (500 rads) embryos were a linear function of the log ... | 1977 | 845990 |
| [serologic survey for the determination of antibodies against various virus infections, mycoplasma, beta hemolytic a streptococcus and toxoplasma gondii, performed on children of a state-of-mexico municipality]. | a seroepidemiologic inquest was carried out in 667 children from the county of huixquilucan, mexico, looking for serum antibodies against infections caused by the following microorganisms: epstein-barr virus; cytomegalovirus; syncytial respiratory; para-influenza 1, 2 and 3; measles; rubella; mumps; mycoplasma pneumoniae, beta hemolytic a streptococcus and toxoplasma gondii. the findings are reported. considerations are made on the incidence of these diseases in different age groups and a compar ... | 1977 | 911440 |
| burkitt's lymphoma in australia. | an australian case of burkitt's lymphoma is reported. the clinical features of large ovarian masses and subsequent bone marrow invasion, as well as the results of investigations related to the epstein-barr virus, were more consistent with the american than the african type of burkitt's lymphoma. after a good initial response to cyclophosphamide and vincristine, the tumour rapidly became resistant to these and other therapeutic measures and the patient died 10 months after diagnosis. | 1977 | 859483 |
| sequential evaluation of cutaneous delayed hypersensitivity responses to recall and to lymphoid cell line antigens in burkitt's lymphoma. | delayed cutaneous hypersensitivity reactions to standard recall antigens (candidin, mumps and ppd), to crude membrane extracts of a cell line derived from burkitt's lymphoma (raji) and to cell line derived from normal lymphocytes (f265) were sequentially evaluated in 44 patients with burkitt's lymphoma. sixteen patients (36%) manifested delayed hypersensitivity responses to the standard antigens and seven (16%) to the raji membrane extract at presentation. following successful chemotherapy, ther ... | 1977 | 903183 |
| membrane antigen expression in epstein-barr virus-infected raji cells in the presence of phosphonoacetic acid. | the expression of the epstein-barr virus (ebv)-induced membrane antigen (ma) in raji cells experimentally infected with ebv concentrates was inhibited by phosphonoacetic acid (paa) as determined by membrane immunofluorescence and inhibition of antibody-dependent lymphocyte cytotoxicity. paa was only effective if present during the first 24 hr following virus adsorption, indicating that the synthesis of ma was primarily a late viral gene function requiring viral dna synthesis. | 1977 | 18625491 |
| transcription and circular dichroism of chromatin in lymphoblastoid cell lines during proliferation and quiescence. | rna polymerase activity of nuclei and positive circular dichroism ellipticity in the 250--300 nm region of chromatin were studied in three lymphoblastoid cell lines: hri, an epstein-barr virus (ebv) positive virus-producing line; raji, and ebv positive virus-producing line; raji, an ebv positive non-producer line; and su-amb-1, and ebv negative line. raji consistently exhibited the highest and su-amb-1 the lowest polymerase activity and ellipticity. all lines showed higher rna polymerase activit ... | 1978 | 718933 |
| [bcg vaccination, cancer and infectious mononucleosis. a retrospective study of hospitalized patients]. | a retrospective study (1966--1976) of patients hospitalized for cancer was carried out to determine a possible relationship with bcg vaccination, with a control group matched for age and sex and a similar study concerning infectious mononucleosis. among 105 patients with cancer, 54 (51.42%) had been previously vaccinated with bcg, 56 (53.33%) in the control group, and 22 (33.84%) among the 65 patients with infectious mononucleosis (p less than 0.05, x2). the mean age on admission for cancer or i ... | 1978 | 711498 |
| spontaneous resolution of severe aplastic anemia associated with viral hepatitis a in a 6-year-old child. | recovery from acquired aplastic anemia associated with hepatitis is rare. this case of a 6-year-old boy with severe aplastic anemia is the first reported association of this disease with a hepatitis a infection. antibody to hepatitis a (anti-ha) was not detected on admission, but was detected three weeks later. infection with hepatitis b virus, cytomegalovirus (cmv), and epstein-barr virus (ebv) were excluded. the peak titer of anti-ha was higher than would be expected for passive transfer of an ... | 1978 | 752262 |
| epstein-barr virus (ebv) receptors, complement receptors, and ebv infectibility of different lymphocyte fractions of human peripheral blood. i. complement receptor distribution and complement binding by separated lymphocyte subpopulations. | 1978 | 340053 | |
| [epidemiology of burkitt's lymphoma in tropical areas - its relationship with malaria (author's transl)]. | epidemiology of tropical burkitt's lymphoma shows the concomitant existence of the three following characteristics in endemic areas: - fairly dense rural population with a low standard of living; - early occurrence of primary infection by the epstein-barr virus (whose genome is always present in all tumour cells); - stable malaria. the social and economic level of these areas accounts for the specific features of the viral infection. climatic factors determine permanent of prolonged transmission ... | 1978 | 345230 |
| human t lymphocyte cell line producing colony-stimulating activity. | we derived a permanent human t lymphocyte cell line that elaborates a potent colony-stimulating activity (csa). the line was established with spleen cells from a patient with a t lymphocyte variant of hairy-cell leukemia. these cells form rosettes with sheep erythrocytes, show a proliferative response to phytohemagglutinin, and are lysed by antithymocyte globulin. they do not synthesize immunoglobulin, nor do they contain epstein-barr virus. csa is regularly detected in the supernatant medium af ... | 1978 | 308824 |
| establishment of a t-cell line from human lymphosarcoma. | a leukemic t-cell line, designated as tall-1, has been established in continuous culture from the bone marrow of a patient with a leukemic phase of t-cell lymphosarcoma. tall-1 cells have t-cell properties and lack epstein-barr virus or its genome. the cells of tall-1 line are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphological, and surface features. | 1978 | 305872 |
| cancer, viruses and environmental factors. | the genesis of burkitt's lymphoma is visualized as proceeding in three steps: i. primary ebv infection affects the young child, probably at a relatively high multiplicity. it immortalizes a certain number of b-lymphocytes in vivo. ii. this is followed by the impact of an environmental promoting agent, perhaps chronic holoendemic malaria, providing a chronic stimulus to the proliferation of the ebv-carrying preneoplastic cells. iii. chromosomally abnormal variants appear in the stimulated tissue ... | 1978 | 231549 |
| studies in porphyria. vii. induction of uroporphyrinogen-i synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes. | a 50% reduction in the activity of uroporphyrinogen-i (uro) synthase in liver, erythrocytes, and cultured skin fibroblasts characterizes all patients with clinically active acute intermittent porphyria (aip). the same enzyme defect has also been demonstrated in the erythrocytes and skin fibroblasts of completely latent gene carriers of this disorder and presumably exists in the liver as well. in this study, we examined whether or not the formation of uro-synthase is impaired in aip cells using l ... | 1978 | 621286 |
| fatal aplastic anaemia complicating infectious mononucleosis. | a 7-year-old boy developed fatal aplastic anaemia, 2 weeks after the first signs of infectious mononucleosis. although some drugs were administered, infection with the epstein-barr virus, leading to infectious mononucleosis, is assumed to be the cause of this aplastic anaemia. some mechanisms possibly leading to the aplasia are discussed. | 1978 | 625631 |
| immunohistochemistry of local immunoglobulin production in nasopharyngeal carcinoma. | immunohistochemical investigations by the immunoperoxidase method have been carried out on sections of biopsy specimens obtained from the primary tumour sites of patients with nasopharyngeal carcinoma (npc). it was found that, in many of the sections thus examined, there was an accumulation of plasma cells, particularly of the iga type, in the connective tissues surrounding nests of npc cells. similar accumulation of plasma cells in the subepithelial connective tissues was likewise observed in a ... | 1978 | 348224 |
| infectious mononucleosis associated with rhabdomyolysis and renal failure. | acute rhabdomyolysis and renal failure occurred in a 16-year-old boy with infectious mononucleosis; recovery was complete. renal failure is a rare complication of infectious mononucleosis. rhabdomyolysis has been reported only once in association with the epstein-barr virus, but has frequently been associated with influenza virus infections. prospective studies measuring creatine phosphokinase enzymes should establish the frequency of rhabdomyolysis in viral infections. | 1978 | 628861 |
| a histopathological study of lymphoid tissue reaction to metastatic nasopharyngeal carcinoma in nude mice. | in attempts to heterotransplant human npc into nude mice, using seven cultured cell lines, we have succeeded in growing a carcinoma simplex, composed of epstein-barr virus-determined nuclear antigen-positive and epstein-barr virus genome-positive cancer cells, at the injected site with two of the cell lines. these originated from a spindle-cell carcinoma (chinese npc-204) and from a combined-cell carcinoma (chinese npc-501), respectively. during the first few passages, wandering macrophages were ... | 1978 | 310417 |
| nasopharyngeal and adjacent neoplasms: a clinico-pathologic and immunologic study. | thirteen cases of nasopharyngeal carcinoma (npc) and 16 cases of non-npc tumors in the nasopharynx or in adjacent locations were investigated clinically, immunologically, and pathologically. all tumors were classified according to the tnm classification, and the stage and course of the disease was correlated with the histological tumor type, the t- and b-cell distribution in tumor tissue and in the peripheral blood, as well as with antibody titers against epstein-barr virus (ebv). the results sh ... | 1978 | 305242 |
| rabbit antiserum against daudi-cell membrane fractions detects cell surface antigens present on subpopulations of human lymphocytes. | an antiserum was produced by immunization of rabbits with membrane preparations of a human lymphoblastoid b cell line, daudi. after absorption with a human endometrial carcinoma cell line, this antiserum appeared to be specific for antigen(s) present on adult and fetal thymocytes as well as on tonsillar lymphocytes but absent, or present in very small amounts, on normal or phytohemagglutinin- (pha) stimulated peripheral blood lymphocytes (pbl). when t and b cell-enriched fractions from tonsillar ... | 1978 | 307019 |
| anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation. | a viral inhibitor(s) is released in the supernate of mixed cultures containing human or mouse lymphocytes and cells from certain lines. the inhibitor is active against a variety of unrelated viruses and is a protein that is not toxic for cells. it does not inactivate viruses directly, but inhibits viral replication through an intracellular mechanism that involves synthesis by the cells of both rna and protein. these characteristics identify the inhibitor as an interferon. the anti-viral activity ... | 1978 | 650155 |
| fever of undetermined origin: role of cytomegalovirus and epstein-barr virus. | roles of various infections, neoplasms and granulomatous diseases in fever of unknown origin were studied in 22 patients. bacterial infections were responsible in seven (32 percent), herpes viruses in five (23 percent), neoplasms in four (18 percent) and granulomata in two (9 percent) cases. patients with herpes infections had initially no clinical or routine laboratory clues to viral involvement, and were given an intensive workup for 5 to 15 days. the diagnosis was made on the basis of cytomeg ... | 1978 | 716387 |
| sister chromatid exchange in patients with viral disease. | sister chromatid exchange (sce) frequencies were studied in differentially stained chromosomes from lymphocytes of 17 patients with viral disease. the mean sce score for the patients was 8.7 +/- 2.9 standard deviations. sce scores were significantly elevated in the patients compared with the controls (p less than 0.01); however, variability in sce means was observed in the patients. sce elevations were also present in long term cultured epstein barr virus positive human b lymphocytes. | 1978 | 233771 |
| clones of human lymphoblastoid cell lines producing antibody to tetanus toxoid. | 1978 | 211002 | |
| cultural, morphological, cell membrane, enzymatic, and neoplastic properties of cell lines derived from a hodgkin's disease lymph node. | a neoplastic cell line (designated hut11) has been established in continuous culture from an involved lymph node of a patient with stage iia hodgkin's disease of the mixed cellularity type. the hut11 line has been morphologically heterogeneous, consisting of mononucleate lymphoid-like cells, polygonal epithelioid cells, and mono-, bi-, and multinucleate giant cells. four clones initiated from isolated binucleate giant cells of the hut11 line also have been successfully established as continuous ... | 1978 | 209894 |
| transfusion-related short-incubation hepatitis in hemophilic patients. | nine episodes of a unique short-incubation form of hepatitis were observed during five years in six hemophilic children after infusion with commercial factor viii concentrate prepared by two different manufacturers. five patients with a single episode had no previous infusion for 14 months to 14 years. one patient with several episodes had no previous infusion for at least seven months preceding each episode. the illness was mild and self-limited. no seroconversions to cytomegalovirus, epstein-b ... | 1978 | 210302 |
| stimulation of antibodies to epstein-barr virus (ebv) in acute viral infections. | acute and convalescent sera from 77 patients with serologically confirmed influenza, measles and adenovirus infections and from 36 healthy controls were tested for the level of antibodies to epstein-barr (eb) virus. in the three groups of patients significantly higher titers of antibodies to eb viral capsid antigen (vca) were found as compared to the controls. in 19 patients twofold or higher rise in antibody titers between the first and second blood sample was demonstrated. it is suggested tha ... | 1978 | 209767 |
| recovery of transforming ebv from non-producer cells after superinfection with non-transforming p3hr-1 ebv. | cells of the raji and nc37 lines can be induced by chemical inducers, such as brdurd and idurd, or the tumor-promoter tpa to ea-expression only, but do not reveal any vca synthesis. after superinfection by nontransforming p3hr-1 ebv, however, a varying percentage of the cell population shows vca synthesis and releases infectious viral particles. the recovered virus differs biologically from p3hr-1 ebv since it transforms human umbilical cord blood lymphocytes into ebna-positive lymphoblastoid ce ... | 1978 | 212377 |
| detection of epstein-barr virus in biopsied malignant lymphoma cell and its continuous culture. | in more than 80% of tumor cells in the pericardiac effusion of a case of malignant b-cell lymphoma, epstein-barr virus-determined nuclear antigen (ebna) was detected by the anticomplement immunofluorescence test. moreover, herpestype virus particles, although few in number, were demonstrated in the nucleus of lymphoma cells by an electron microscope. tumor cells in the pericardiac effusion were seeded at 98% purity after centrifugation on ficoll-conray and, soon after plating, they proliferated ... | 1978 | 210075 |
| [incidence and specificity of circulating immune complexes in infectious mononucleosis (proceedings)]. | occurrence of immune complexes in infectious mononucleosis has been investigated by the 125i clq binding assay. increased serum clq-binding activity was found in 87% of the 23 patients studied during the acute stage of the disease. the serum clq-binding material detected has properties identical to those of immune complexes. igg antibodies dissociated from the complexes at acid ph and f (ab)'2 fragments obtained after treatment by pepsin appeared to be directed against the viral capsid antigen o ... | 1978 | 211580 |
| antigen-inducing ability of herpesvirus papio in human and baboon lymphoma lines, compared to epstein-barr virus. | herpesvirus papio(hvp)-carrying baboon lymphoblastoid lines do not express a nuclear antigen like the epstein-barr virus(ebv)-determined nuclear antigen (ebna), as judged by in situ anticomplement fluorescence staining, although the carry multiple viral genomes and, in the case of producerlines, early antigen (ea) and viral capsid antigen (vca) that cross-react with the corresponding human ebv-determined antigens. to test whether the lack of in situ nuclear antigen expression is a property innat ... | 1978 | 210135 |
| epstein-barr virus as the cause of a human cancer. | 1978 | 210391 | |
| epidemiological evidence for causal relationship between epstein-barr virus and burkitt's lymphoma from ugandan prospective study. | results from a prospective sero-epidemiological study initiated in uganda in 1971 indicate that children with high antibody titres to epstein-barr virus structural antigens are at high risk of developing burkitt's lymphoma. these findings strongly support a causal relationship between the epstein-barr virus and burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances. | 1978 | 210392 |
| heterogeneity of epstein-barr virus. iii. comparison of a transforming and a nontransforming virus by partial denaturation mapping of their dnas. | the dnas of a transforming and a nontransforming epstein-barr virus strain, b95-8 and p3hr-1, were compared by partial denturation mapping. b95-8 viral dna showed a homogeneous denaturation pattern. in contrast, p3hr-1 viral dna was heterogeneous, containing at least two classes of molecules, classified into groups a and b and present in a ratio of about 2:1 to 3:1. no evidence could be obtained that molecules from both groups a and b contain identical sequences present in different orientations ... | 1978 | 211256 |
| [[auto] critique of a tumor virology (author's transl)]. | 1978 | 211545 | |
| improved detection of virus-specific igm antibodies. elimination of non-specific igm binding. | a non-specific reaction between human igm and cytoplasmic structures of virus infected cells can often be observed if mgm antibodies to virus antigens are detected by indirect immunofluorescence or by immuno enzyme assays. formaldehyde selectively inactivates the cytoplasmic receptors for human igm without affecting the virus structural proteins. alternatively, receptor-free antigens can be obtained by isolation of nuclei from virus infected cells. due to reduced background, a more specific and ... | 1978 | 211190 |
| studies of epstein-barr virus (ebv)-associated nuclear antigen: solubilization from raji cell chromatin with 5 m-urea-2 m-nacl and fractionation on hydroxyapatite. | ebna-containing chromatin from raji cells was solubilized by treatment with high concentrations of urea and salt and fractionated by hydroxyapatite chromatography. fractions eluting at different phosphate concentrations were analysed for the presence of ebna by means of an anti-ebna-specific 125i-labelled igg absorption assay. the antigen was found in fractions containing non-histone chromatin proteins. | 1978 | 211194 |
| persistence of both human cytomegalovirus and epstein-barr virus genomes in two human lymphoblastoid cell lines. | by dna-dna reassociation kinetic analysis, less than one genome equivalent per cell of human cmv-dna was found in two lymphoblastoid cell lines, one derived from the peripheral blood of a congenitally infected male infant at the age of 21 months (d4 cell line), the other obtained by co-cultivation of lethally x-irradiated cells from the 9-month lymphoblastoid cell line previously described by joncas et al. (1975) with cord blood leukocytes of a female newborn (m1 cell line). human cmv antigens c ... | 1978 | 211195 |
| chloroquine enhances epstein-barr virus expression. | 1978 | 211434 | |
| presence of ebna in nasopharyngeal carcinoma and control patient tissues related to ebv serology. | 1978 | 212372 | |
| the values of epstein-barr virus titers as a diagnostic shortcut in infectious mononucleosis: two case reports. | 1978 | 212244 | |
| dna of epstein-barr virus. iii. identification of restriction enzyme fragments that contain dna sequences which differ among strains of epstein-barr virus. | previous kinetic and absorption hybridization experiments had demonstrated that the dna of the b95-8 strain of epstein-barr virus was missing approximately 10% of the dna sequences present in the dna of the hr-1 strain (r.f. pritchett, s.d. hayward, and e. kieff, j. virol. 15:556-569, 1975; b. sugder, w.c. summers, and g. klein, j. virol. 18:765-775, 1976). the hr-1 strain differs from other laboratory strains, including the b95-8 and w91 strains, and from virus present in throat washings from p ... | 1978 | 211267 |
| [hodgkin's disease: effect of spenectomy on the immune status (author's transl)]. | in 22 untreated hodgkin's patients the following parameters were studied before and after splenectomy: the total wbc, lymphocytes, b- and t-cells and mitogenic stimulation of peripheral lymphocytes using autologous and control serum. the results were correlated to patient groups with favourable and unfavourable prognosis according to pathological stage, histology, spleen involvement and constitutional symptoms. 1. all patients. significant increase of the absolute number of peripheral lymphocyte ... | 1978 | 211317 |
| interaction of the b95-8 and p3hr-1 substrains of epstein-barr virus (ebv) with peripheral human lymphocytes. | two substrains of the epstein-barr virus derived from the b95-8 and p3hr-1 cell lines were studied for their interaction with human peripheral lymphocytes. it has been previously shown that b95-8 virus has and p3hr-1 virus lacks lymphocyte-transforming ("immortalizing") properties. dna stimulation induced by b95-8 virus showed a good correlation with the number of surface ig-positive cells. p3hr-1 virus added before b95-8 virus completely abolished the stimulation of dna synthesis. it also preve ... | 1978 | 212371 |
| human malignant lymphomas in vitro. characterization of biopsy cells and establishment of permanent cell lines. | a series of 55 biopsies from different types of malignant lymphomas were characterized in short-term culture experiments and during prolonged growth in vitro. the majority of the lymphocytic lymphomas and half of the histiocytic lymphomas expressed surface immunoglobulin, either in monoclonal or polyclonal form, indicating b-lymphocyte derivation. no lysozyme production was noted in either type of lymphoma, giving further support to the notion that histiocytic lymphomas are not truly histiocytic ... | 1978 | 211794 |
| infection with epstein-barr virus. | 1978 | 212156 | |
| detection of epstein-barr virus antigens and antibodies by peroxidase-labeled specific immunoglobulins. | detection of the epstein-barr (ebv) antigens, early antigen (ea), viral capsid antigen (vca), and nuclear antigen (ebna) by the indirect immunoperoxidase technique was highly sensitive. antibody titers to ebna, ea, and vca were determined in more than 25 sera of patients with burkitt lymphoma (bl), nasopharyngeal carcinoma (npc), or normal persons. a good correlation between the titers of these antigens was obtained by the immunoperoxidase and immunofluorescence methods. the indirect (anti-igg) ... | 1978 | 212523 |
| effects of adenine arabinoside on lymphocytes infected with epstein-barr virus. | low concentrations of adenine arabinoside inhibited growth of two epstein-barr virus producer cell lines in culture, while not significantly affecting a nonproducer cell line and a b-cell-negative line. these observations were extended to include freshly infected cells. mitogen-stimulated human umbilical cord blood lymphocytes were unaffected by the drug at concentration levels that inhibited [3h]thymidine incorporation into the dna of epstein-barr virus-stimulated cells. dna synthesis in epstei ... | 1978 | 212577 |
| purification of the epstein-barr virus-determined nuclear antigen from epstein-barr virus-transformed human lymphoid cell lines. | the epstein-barr virus-determined nuclear antigen (ebna) was purified from extracts of the human lymphoid cell lines raji, namalwa, and b95-8/mld by two different methods. in the first approach, the apparently native antigen was purified 1,200-fold by a four-step procedure involving dna-cellulose chromatography, blue dexptran-agarose chromatography, hydroxyapatite chromatography, and gel filtration, employing complement fixation as the assay procedure. such ebna preparations specifically inhibit ... | 1978 | 212583 |
| activation of latent epstein-barr virus by antibody to human igm. | 1978 | 213727 | |
| promising new antiherpes agent being tested in humans. | 1978 | 212617 | |
| induction of nuclear antigen (ebna) synthesis without transformation in human cord lymphocytes by p3hr-1 strain of epstein-barr virus. | 1978 | 213884 | |
| alkaline phosphatase in epstein-barr viral nuclear antigen--positive cell lines. | the production and nature of alkaline phosphatase were studied in epstein-barr viral nuclear antigen-positive, surface membrane immunoglobulin negative-cell lines established from two patients, one with acute myeloid leukemia and one with acute lymphoblastic leukemia. the acute myeloid leukemia-derived cells contained myeloid alkaline phosphatase, while the acute lymphoblastic leukemia-derived cells contained lymphoid alkaline phosphatase. the presence of the myeloid-specific enzyme in a surface ... | 1978 | 211588 |
| chromosomal association of an epstein-barr virus-associated nuclear antigen. | 1978 | 212669 | |
| sensitivity of the transforming and replicative functions of epstein--barr virus to inhibition by phosphonoacetate. | disodium, phosphonoacetate (pa), at concentrations of 50 to 200 microgram/ml, which still allowed continued growth of the eb virus-transformed b95-8 cell line on a routine culture regimen, was able to inhibit the production of virus capsid antigen and of virus particles by these cells down to very low but finite levels which persisted despite prolonged treatment. further experiments measured the effects of these same drug concentrations on the eb virus-induced in vitro transformation of foetal c ... | 1978 | 211188 |
| antibody-dependent cellular cytotoxicity against epstein-barr virus-associated antigens in african patients with nasopharyngeal carcinoma. | antibody-dependent cellular cytotoxicity (adcc) was performed on serum samples from african patients with nasopharyngeal carcinoma (npc) to determine whether antibody titers determined by this assay might be of prognostic value in this disease. the serum donors were divided into two groups: (1) those individuals who died within 2 years following diagnosis of npc; and (2) individuals who responded well to therapy and surivived for more than 2 years following diagnosis. the adcc gmt for the surviv ... | 1978 | 212366 |
| antibody patterns to herpesviruses in kaposi's sarcoma. ii. serological association of american kaposi's sarcoma with cytomegalovirus. | the prominent finding of this extended serologic analysis on american and african kaposi's sarcoma (ks) patients and appropriately matched control groups is the detection of a specific serologic association of cytomegalovirus (cmv) with american ks patients. all american ks sera contained cmv antibodies and their geometric mean titers (gmt) were significantly higher than those in sera of melanoma patients (gmt ratio k = 5.3 to 7.7 by complement fixation [cf], k = 8.9 by indirect hemagglutination ... | 1978 | 212367 |
| isolation of a herpesvirus-specific dna polymerase from tissues of an american patient with burkitt lymphoma. | a dna polymerase (dna nucleotidyltransferase) has been partially purified from a neck mass of an american patient with burkitt lymphoma and separated from the cellular dna polymerases. the molecular weight of the enzyme was approximately 90,000. the enzyme differs from the cellular dna polymerases, but resembles herpes-virus-induced dna polymerase in its primer template preference, high monovalent cation requirement for activity, and sensitivity to phosphonoacetate. enzyme activity was inhibited ... | 1978 | 212756 |
| primary epstein-barr virus infections in african infants. i. decline of maternal antibodies and time of infection. | 1978 | 212369 | |
| primary epstein-barr virus infections in african infants. ii. clinical and serological observations during seroconversion. | 1978 | 212370 | |
| prospects of vaccines against cancer in man. | preventive immunization is the cheapest and most effective approach to the management of epidemic disease. certain forms of cancer, including burkitt's lymphoma, carcinoma of the cervix, primary liver cancer, acute leukaemia and breast cancer show many characteristics of epidemic disease, and the possibility of producing preventive vaccine against these conditions merits serious consideration. | 1978 | 212839 |
| [isolation of the epstein-barr virus in suspension cell lines obtained from persons with different forms of hemoblastosis]. | isolation of ebv from patients with different types of haemoblastosis by establishing virus-producing cell lines is described. ebv was isolated from patients with myelogenous leukemia in 71%, hodgkin's disease--in 22%. ebv was also isolated from 1 patient with lung tumor and leukemogenic reaction. all 8 established cell lines produced ebv in 0.5--3% of cells. the cells of the lines concerned are lymphoblasts and show b-cell characteristics. | 1978 | 212872 |
| serological reactivities of human and baboon sera against ebna and herpesvirus papio-determined nuclear antigen (hupna). | 1978 | 213288 | |
| [virus diseases of the lymphatic system. differential diagnosis and therapy]. | 1978 | 212661 | |
| [complex antibody studies in suspected infectious mononucleosis]. | 1978 | 212703 | |
| lysosomal acid hydrolases in established lymphoblastoid cell lines, transformed by epstein-barr virus, from patients with genetic lysosomal storage diseases. | lysosomal acid hydrolases were determined in established lymphoblastoid cell lines, transformed in vitro by epstein-barr virus (ebv) from lymphocyte-rich cell populations isolated from the peripheral blood of patients with genetic lysosomal storage diseases--hurler syndrome, scheie syndrome, gm1-gangliosidosis type 1 and type 2, tay-sachs disease, and i-cell disease--and from obligate heterozygotes for these diseases. the respective enzyme activity was undectectable in lymphoblastoid cells from ... | 1978 | 213379 |
| insulin inhibits cellular and herpes simplex virus dna synthesis in transformed lymphoblastoid cell lines. | treatment of uninfected and herpes simplex virus-infected lymphoblastoid cells with 4 units of insulin per milliliter resulted in the inhibition of both cellular and viral dna synthesis. | 1978 | 213399 |
| activation of endogenous type c virus in balb/c mouse cells by herpesvirus dna. | several virion and nonvirion dnas were tested for the ability to activate endogenous type c virus in balb/c-derived mouse cells using the calcium precipitation technique. the dnas from all herpesviruses tested activated xenotropic type c virus synthesis. these included dnas from herpes simplex virus types 1 and 2, epstein-barr virus, human cytomegalovirus, sa8 virus, infectious bovine rhinotracheitis virus, pseudorabies virus, and herpes saimiri virus (m-dna). in contrast, dnas from vaccinia vir ... | 1978 | 212761 |
| latent viruses and bell's palsy in children. | 4 children with unilateral facial palsy--bell's palsy (bp)--had serological evidence of primary infection with epstein-barr virus (ebv). concomitant infection with cytomegalovirus (cmv) was demonstrated in 1 child while in all 4 children a rise in antibody titers to an additional one or two viruses was demonstrated. the viruses involved were herpes simplex, cmv and adenovirus which are latent in humans. immunosuppression induced by ebv and steroid treatment may cause reactivation of these viruse ... | 1978 | 213283 |
| seroconversion against epstein-barr virus in two nonhuman primate species infected by the oropharyngeal route. | transforming epstein-barr virus (ebv) was inoculated into eight squirrel monkeys (saimiri sciureus) by spraying of viral concentrates into the nose and throat. virus was inoculated into three marmosets (two saguinus oedipus and one calithrix jacchus jacchus) by direct injection into nasopharyngeal tissue. two of these squirrel monkeys seroconverted after repeated inoculation as determined by the presence of ebv-specific antibodies to early antigen and viral capsid antigen. one squirrel monkey ha ... | 1978 | 213505 |
| intracisternal tubular inclusions in nasopharyngeal carcinoma. | biopsy specimens obtained from 20 cases of nasopharyngeal carcinoma were examined under electronmicroscope for the presence of intracisternal tubular inclusions (iti). in eight (40 per cent) of them these inclusions could be identified. although the morphogenesis and significance of these iti are not clearly understood, they have been found in several autoimmune and viral diseases, including infectious mononucleosis, a disease caused by ebv, and burkitt's lymphoma, which is closely associated wi ... | 1978 | 213517 |
| two epstein-barr virus-associated dna polymerase activities. | we have partially purified and characterized two separate dna polymerase activities associated with epstein-barr virus (eb virus). one activity is present in eb virus producer cell lines but not in nonproducer or negative cell lines. it adheres more strongly to deae-cellulose than any host cell enzymes, eluting at 210 to 270 mm potassium phosphate buffer. further elution from phosphocellulose and sedimentation in glycerol gradients yields an enzyme purified 900-fold with an s value of 8.3. the s ... | 1978 | 213439 |
| epstein-barr virus in somatic cell hybrids between mouse cells and human nasopharyngeal carcinoma cells. | somatic cell hybrids between mouse cells and cells derived directly from npc biopsies were produced in order to study the association of the epstein-barr virus (ebv) genome and the expression of epstein-barr nuclear antigen (ebna) with the human chromosome(s). all attempts to correlate the presence of ebv-dna and the expression of ebna with the presence of a particular human chromosome(s) showed that the segregation of ebv-dna or of ebna and human chromosomes was dysconcordant. the data, therefo ... | 1978 | 213442 |
| [recent developments in the field of infectious diseases]. | a résumé is presented of recent developments in the field of infectious diseases of particular interest of practising physicians. examples are given to illustrate recent discoveries concerning the frequent misuse of antibiotics, the problem of infections developing in hospitalized patients, the biology of microbial infection, the etiology of well-known illnesses, new infectious diseases, and the development of vaccines. it is evident that the rate at which new and important information is eviden ... | 1978 | 213830 |
| tumor viruses and human cancer. ii. dna tumor viruses. | 1978 | 214057 | |
| [an autopsy case of acute myeloblastic leukemia with persistent high anti ebv-antibody titer (author's transl)]. | 1978 | 213625 | |
| screening of anti-b cell antibodies in the sera of renal transplant recipients by using daudi cell line. | in order to examine the presence of antibodies against b cells, 83 sera obtained from 55 renal transplant recipients were screened by microcytotoxicity test using daudi cell line. out of 83 samples, 12 were pretransplant sera, 62 were post-transplant sera and 9 were from the patients whose grafts has been removed due to rejection. for the purpose of improving the reliability of the tests, 5 different rabbit complements were selected and cytotoxicity tests with them were carried out simultaneousl ... | 1978 | 213630 |
| epstein-barr virus-regulation studies on somatic-cell hybrids derived from the fusion of burkitt's lymphoma and nasopharyngeal carcinoma cells with human or mouse partners. | 1978 | 215519 | |
| expression of latent epstein-barr virus genomes in human epithelial/burkitt's lymphoblastoid hybrid cells. | expression of latent epstein-barr virus genomes in somatic-cell hybrids of burkitt's lymphoblastoid cells has been studied. treatment of the hybrid cells, d98/raji and d98/hr-1, with iudr induced the formation of ea and vca and replication of virus dna, whereas the same treatment of raji cells induced only the formation of ea. the patterns of transcription of virus genomes in these three cell lines were, however, very similar: 25% without treatment with iudr, 30% immediately after the treatment ... | 1978 | 215523 |
| interaction between epstein-barr virus and type-c virus in human cells. | the interaction between ebv and type-c viruses was studied in our fvnc experimental system, in which ebv and type-c viral genomes are contained in each cell. the data indicate that the human lymphoid fvnc cells are sensitive to both ebv and type-c virus exposure, showing high frequencies of induction of both repressed viral genomes. the two different viral genomes may be associated with different chromosomes in individual cells. | 1978 | 215524 |
| epstein-barr virus-related serology in nasopharyngeal carcinoma and controls. | 1978 | 215525 | |
| clinical evaluation of ebv serology in american patients with nasopharyngeal carcinoma. | there is now extensive immunological, biological and biochemical evidence to support a possible etiological relationship between ebv and npc in patients from different geographical locations. besides providing information on the question of etiology, the results from immunological investigations suggest that antibodies to some of the ebv-associated antigens might also be of clinical importance in the diagnosis and prognosis of npc. to determine the possible clinical application of ebv serology t ... | 1978 | 215526 |
| the genetic and antigenic basis for the iga antibody response to epstein-barr viral capsid antigen. | 1978 | 215527 | |
| presence of epstein-barr virus specific iga in saliva of nasopharyngeal carcinoma patients: their activity, origin and possible clinical value. | 1978 | 215528 | |
| detection of b-lymphocyte (b-cell)-associated antigens on human leukemic lymphocytes. masking of membrane antigens. | an indirect immunofluorescent technic has been used for rabbit antisera (anti-ep) that demonstrated complement-dependent cytotoxicity against human leukemic lymphocytes but not against normal blood lymphocytes. with the immunofluorescent technic, the antisera were found to react with 2--23% of normal blood lymphocytes. simultaneous staining of normal cells with anti-ep and for surface immunoglobulins (sig) on bone-marrow-derived b-cells showed that the proportions of stained cells were similar t ... | 1978 | 213964 |
| histopathological types of nasopharyngeal carcinoma in a low-risk area: japan. | npc in japan was studied histopathologically by examining 816 npcs from among 3 338 biopsies from patients with tumours of the nasopharynx and other parts of the upper respiratory system. in addition, a comparative study on npc among taiwanese and an immunoserological study were carried out. when comparing histological types of malignant tumours of the upper respiratory tract, poorly-differentiated squamous-cell carcinoma predominated only in those of the nasopharynx. malignant nasopharyngeal tu ... | 1978 | 215515 |
| complete heart block in epstein-barr myocarditis. | 1978 | 214746 | |
| antigenic content of an in vitro cellular immunity reactive cell surface extract of raji cells. | antigenic content of a raji cell surface extract (ts) was studied by sequential abosrption of rabbit antiserum to this extract with different cells. anti-ts was first allowed to react exhaustively with human blood cells followed by hela cells and human diploid fibroblasts. the residual reactivity was studied by stepwise absorption with an ebv-negative b lymphoblastoid cell line, bjab, and then with b1--19, a clone derived from ebv transformed bjab cells. these processes delineated three kinds of ... | 1978 | 215106 |
| histological typing of nasopharyngeal carcinoma. | there is little agreement about correlations between histological type and the epidemiological and biological characteristics of npc. this is largely due to variations in terminology and diagnostic criteria. the use of the terminology and definitions proposed by who would facilitate and improve international comparisons. | 1978 | 215516 |
| a study of epstein barr virus receptor activity in cell free extracts of human lymphoblastoid cells. | epstein barr virus (ebv) receptor activity in cell free extracts is operationally defined as one which causes a reduction in the effective concentration of the early antigen inducing particles of an ebv preparation when the latter is preincubated with the extract before infection. such activity was detected in the surface extract of raji cells and to a lesser extent in that of bjab cells, both of which are b lymphoblastoid cells that are susceptible to infection with ebv. receptor activity was n ... | 1978 | 215107 |
| ebna antibodies are more useful than complement fixing antibodies in monitoring infectious mononucleosis patients. | thirty-six patients with infectious mononucleosis (im) were followed prospectively for both anti-epstein-barr virus nuclear antigen (ebna) and complement-fixing antibodies using the soluble ebv antigen (cf/s). discrepancies in time between the two reactivities were found, due to the differences in sensitivity of the tests. it is suggested that, in clinical virology laboratories, ebna and not cf/s tests be used. | 1978 | 214180 |
| biology of the human malignant lymphomas. iv. functional characterization of ten diffuse histiocytic lymphoma cell lines. | ten consecutive diffuse histiocytic lymphoma (dhl) cell lines established in our laboratory were studied for the presence of epstein-barr virus (ebv) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors to sheep erythrocytes, complement, and the fc fragment of immunoglobulin. in agreement with previous studies performed on biopsy specimens, our results indicate that the diffuse hist ... | 1978 | 214220 |
| stimulation of peripheral human lymphocytes by autologous ebv genome-carrying lymphoblastoid cell lines. | 1978 | 208783 | |
| latent characteristics of selected herpesviruses. | 1978 | 204166 | |
| [hepatology and immunology]. | immunologic diseases of the liver are exogenous mostly initiated by virus or endogenous initiated by autoaggression. all virus-induced kinds of hepatitis are due to an immune response against inocculated hepatocytes. therefore the hepatitis is limited to the period of complete elimination of virus-infected cells. a strong immune response therefore corresponds with an acute and short hepatitis whilest a weak immune response develops a chronic hepatitis. in contrast, autoimmune hepatitis based on ... | 1978 | 205495 |
| a new tumour-derived transforming strain of epstein-barr virus. | 1978 | 205793 | |
| overview of viral oncology studies in saguinus and callithrix species. | marmoset monkeys are highly susceptible to tumor induction by type c sarcoma viruses and primate lymphotropic herpeviruses. six experimental models were reviewed, three sarcoma models induced by rous, feline or simian sarcoma viruses and three models of lymphoproliferative disease induced by herpevirus saimiri, h. ateles or epstein-barr virus. relative susceptibility of cotton-topped (saguinus oedipus oedipus), white-lipped (s. nigricollis, s. fuscicollis subspecies) and commone (callithrix jacc ... | 1978 | 205860 |