Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| suppression of in vitro epstein-barr virus infection. a new role for adult human t lymphocytes. | studies have been performed on in vitro infection by epstein-barr virus (ebv) of subpopulations of human lymphocytes. b cells of adult peripheral or fetal cord blood transform with equal efficiency, whether assayed by dna synthesis induction or by outgrowth of transformed lymphocytes. in contrast, unfractionated adult lymphocytes transform much less efficiently than those from fetal cord. reconstitution experiments of different cell preparations indicated that this difference was due to a suppre ... | 1977 | 195004 |
| antibodies to epstein-barr virus in nasopharyngeal carcinoma and other neoplastic conditions. | sera from patients with nasopharyngeal carcinoma (npc) or other malignant diseases and from apparently healthy controls were examined for epstein-barr virus (ebv) antibodies. a difference existed in the percentage of positive sera among the groups studied. high-titer antibody levels were observed in the npc group, but no statistical difference was found among other groups of patients and controls. the data reaffirmed the association of ebv with npc but did not support its etiologic role in the d ... | 1977 | 195074 |
| establishment of an epstein-barr virus-determined nuclear antigen-negative human b-cell line from acute lymphoblastic leukemia. | a human b-cell line designated as ball-1 was established from the peripheral blood of a patient with acute lymphoblastic leukemia (all). neither epstein-barr virus (ebv) particles nor ebv-determined nuclear antigen (ebna) was detectable. the morphologic and growth characteristics were clearly distinct from those of numerous ebv-positive lymphoblastoid cell lines previously reported. ball-1 cells probably originated from the donor's leukemia cells as judged from their cytogenetic, morphologic, an ... | 1977 | 195075 |
| presence of epstein-barr virus receptors, but absence of virus penetration, in cells of an epstein-barr virus genome-negative human lymphoblastoid t line (molt 4). | this paper reports a unique type of interaction of epstein-barr virus (ebv) with an ebv receptor-positive, genome-negative human lymphoid t cell line (molt 4), which can be summarized as follows. although molt 4 cells express receptors for ebv, they appear to block the penetration of this virus. these observations are derived from combined studies with immunofluorescence and electron microscopy. it is possible that t cell lines bearing receptors for ebv may express such a control on virus penetr ... | 1977 | 195091 |
| burkitt's lymphoma. | 1977 | 197352 | |
| phenotypic characterisation of a unique non-t, non-b acute lymphoblastic leukaemia cell line. | 1977 | 197411 | |
| human b cell, t cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias. | 1977 | 197412 | |
| marked enhancement of interferon production in 5-bromodeoxyuridine treated human lymphoblastoid cells. | 1977 | 195215 | |
| epstein-barr virus: transformation of lymphocytes separated by size or exposed to bromodeoxyuridine and light. | 1977 | 197699 | |
| transcription of latent epstein--barr virus genomes in human epithelial/burkitt hybrid cells. | 1977 | 197704 | |
| infectious mononucleosis and mononucleosis syndromes. | infectious mononucleosis (im) and cytomegalovirus (cmv) mononucleosis are caused by a primary infection with related viruses, epstein-barr virus (ebv) and cmv. despite the similarity of clinical manifestations, basic differences exist: (1) the heterophil antibody (ha) response is absent in cmv mononucleosis, whereas it is present in im. (2) in im atypical lymphocytosis reflects proliferation of b cells early and of t cells later in the disease course; in cmv mononucleosis the situation appears c ... | 1977 | 195404 |
| the viral etiology of cancer: a realistic approach. | the etiology of cancer resembles that of many other diseases in that multiple factors may be required. because of this, the role or viruses in the etiology of human cancers is especially difficult to assess. when animal tumor systems were used as models, the roles of various predisposing characteristics in virus oncogenesis were elucidated. extrapolation of these findings to the human diseases suggests the importance of genetics, age, hormones, immune competence, and stress in determining suscep ... | 1977 | 195710 |
| development of cell-mediated immunity to epstein-barr herpesvirus in infectious mononucleosis as shown by leukocyte migration inhibition. | eight patients with infectious mononucleosis, aged between 8 and 24, were studied for cell-mediated immunity by the in vitro leukocyte migration inhibition test at acute and convalescent stages. follow-up studies were also carried out at up to 4 months after clinical illness. cell-mediated immunity to epstein-barr virus (ebv) in the peripheral leukocytes from these patients was absent or incipient in all cases during the acute phase, although it was present in lymphocytes from a biopsied lymph n ... | 1977 | 195902 |
| dna of epstein-barr virus. ii. comparison of the molecular weights of restriction endonuclease fragments of the dna of epstein-barr virus strains and identification of end fragments of the b95-8 strain. | incubation of the dna of the b95-8 strain of epstein-barr virus [ebv (b95-8) dna] with ecori, hsu i, sal i, or kpn i restriction endonuclease yielded 8 to 15 fragments separable on 0.4% agarose gels and ranging in molecular weight from less than 1 to more than 30 x 10(6). bam i and bgl ii yielded fragments smaller than 11 x 10(6). preincubation of ebv (b95-8) dna with lambda exonuclease resulted in a decrease in the hsu i a and sal i a and d fragments, indicating that these fragments are positio ... | 1977 | 196117 |
| [studies of heterotransplantation of human leukocytes. part ii. heterotransplantation of normal human peripheral leukocytes into hamsters (author's transl)]. | 1977 | 196124 | |
| a cluster of epstein-barr-virus-associated american burkitt's lymphoma. | we investigated four patients in whom histologically confirmed burkitt's lymphomas developed during a one-year period. they were young adults living within 50 km of each other in a rural area of pennsylvania. two patients were related by marriage, but there was no contact with or between the other two. although the majority of american burkitt's lymphomas are not associated with the epstein-barr virus, all four patients showed spectra and titers of antibodies to antigens related to that virus th ... | 1977 | 196197 |
| replication of ebv in epithelial cells during infectious mononucleosis. | 1977 | 196210 | |
| [demonstration of epstein-barr virus capsid antigen (vca) in lymphocyte cultures from patients with mononucleosis]. | 1977 | 196242 | |
| membrane receptor stripping confirms the association between ebv receptors and complement receptors on the surface of human b lymphoma lines. | complement (c3) receptors, ebv receptors, fc receptors, membrane igm and beta2microglobulin (beta 2m) were individually stripped from the surface of human b lymphoma lines. the cells were subsequently tested for their ability to absorb infectious eb virus. stripping of fc receptors, igm and beta2m did not reduce ebv absorption. stripping of either ebv receptors or c3 receptors eliminated or drastically reduced ebv-absorptive capacity. the results confirm the distinctive association between ebv r ... | 1977 | 198382 |
| diagnostic value of igg and igm antibodies to capsid antigen of epstein-barr virus in infectious mononucleosis. | 1977 | 198482 | |
| enhanced oncogenic behavior of human and mouse cells after cellular hybridization with burkitt tumor cells. | studies were made of the expression of the epstein-barr virus (ebv) in somatic hybrids of burkitt tumor cells and human or mouse cells to determine whether ebv genetic information associated with the capacity to transform leukocytes of human and non-human primates could be maintained and expressed in nonlymphoblastoid cells. data obtained thus far suggest that at least one characteristic associated with cellular transformation (loss of contact inhibition) is expressed only in nonlymphoblastoid c ... | 1977 | 196293 |
| [infectious and parasitic diseases. survey of the current status in 1977]. | 1977 | 196324 | |
| heterogeneity of epstein-barr virus. ii. induction of early antigens (ea) by complementation. | 1977 | 196397 | |
| mechanism of infection by epstein-barr virus. ii. comparison of viral dna from hr-1 and superinfected raji cells by restriction enzymes. | 1977 | 196398 | |
| simple mathematical deductions in the seroepidemiology of viral infections. i. herpesvirus group (herpesvirus hominis, varicella-zoster virus, cytomegalovris, epstein-barr-virus). | large samples of nonselected persons collected in south-west germnay were investigated for the prevalence of serum antibodies to the human herpesviruses hsv, vzv, cmv and ebv. according to "catalytic models", which compare the infection spread to simple chemical reactions of molecules, a mathematical approximation of the serum surveys was performed. through a new deduction of the exponential function y = k (l - e-r+) a simple way was found to estimate the annual attack rates in percent of the su ... | 1977 | 196453 |
| variable phenotypic expression of an x-linked recessive lymphoproliferative syndrome. | investigation of a family with cancer in boys revealed that at least 20 males had the x-linked recessive lymphoproliferative syndrome. a variety of phenotypes occurred: aproliferative phenotypes consisted of aplastic anemia, agranulocytosis or acquired hypogammaglobulinemia; and proliferative phenotypes of b cells included disorders associated with the epstein-barr virus, american burkitt's lymphoma, immunoblastic sarcoma of b cells, fatal infectious mononucleosis or plasmacytoma. the lymphoprol ... | 1977 | 198660 |
| lymphoma, immunodeficiency and the epstein-barr virus. | 1977 | 198662 | |
| induction of plaque-forming cells in cultured human lymphocytes by combined action of antigen and eb virus. | 1977 | 198668 | |
| eb virus-induced b lymphocyte cell lines producing specific antibody. | 1977 | 198669 | |
| burkitt's lymphoma of the jaw in a canadian child. | 1977 | 196731 | |
| immune deficiency of t system with possible t cell regulatory activity defect. | the occurrence of t system immunodeficiency in an infant together with excessive production of igm and, to a lesser degree, of igg and iga, is an unusual combination. a case is reported in which an unremitting lung infection with lymphadenopathy and hepatosplenomegaly developed in a previously healthy two-month-old infant. leukocytosis with lymphocytosis, monocytosis and eosinophilia was rapidly followed by leukopenia and lymphocytepenia after a blood transfusion for anemia. there was a transien ... | 1977 | 194869 |
| spontaneous and induced patterns of the epstein-barr virus (ebv) cycle in a new set of somatic cell hybrids. | a somatic cell hybrid line and its subclones obtained by fusing two burkitt lymphoma lines (raji and namalwa) were examined for the expression of ebv-specific antigens both spontaneously and after induction. the hybrids retained spontaneous early antigen (ea) production at the level characteristic of raji. similarly the more permissive raji pattern dominated the induction of ea by iudr treatment or p3hr-1 virus superinfection. these findings accord with our previous results on independently deri ... | 1977 | 196751 |
| search for inhibitors against herpes simplex virus type-i in cell extracts derived from human lymphoblastoid cell lines. | cell extracts obtained from kb cells and 5 human lymphoblastoid cell lines including 2 from burkitt's lymphoma (p3hr-1 and raji), one each from nasopharyngeal carcinoma (no.223), acute lymphatic leukemia (molt-4) and a healthy person (nc-37) were tested for their inhibitory effects on the growth of herpes simplex virus type-1 (hsv-1) in green monkey kidney (gmk) cells by the plaque titration method. the relationship between the production of hsv-1 inhibitors and the degree of epstein-barr virus ... | 1977 | 196817 |
| recent progress in epstein-barr virus research. | 1977 | 199105 | |
| null-cell properties of a lymphoid cell line from a child with acute lymphoblastic leukaemia. | cultured cells established from the bone marrow of a child with null-cell acute lymphoblastic leukaemia (all) have been studied. after 8 months in vitro, the cytological, cytochemical and immunological properties of the cultured cells were very similar to those of the patient's cells. many of the cultured cells had morphological and cytogenetic abnormalities often found in acute leukaemia. the cells were ebna-negative. this unique culture of all-derived null cells might provide information as to ... | 1977 | 199225 |
| differences in the cona-induced redistribution and agglutination patterns of ebv genome-free and ebv-carrying human lymphoma lines. | 1977 | 196869 | |
| human lymphoblastoid cell lines derived from individuals without lymphoproliferative disease contain the same latent forms of epstein-barr virus dna as those found in tumor cells. | the physical state of the intracellular epstein-barr virus dna was characterized in four human lymphoblastoid cell lines, f-265, nc-37, u-303 l, and pg-1, derived from individuals without lymphoproliferative disease. for comparison, a previously investigated burkitt lymphoma line, raji, and a more recently established cell line of that origin, rael, were also studied. the techniques employed were cscl density gradient centrifugation, glycerol gradient centrifugation, and ethidium bromide-cscl de ... | 1977 | 197024 |
| transformation of lymphocytes by herpesvirus papio. | cotton-topped (ct) or white-lipped (wl) marmoset lymphocytes were transformed in vitro with herpesvirus papio (hvp) into permanently growing lymphoblastoid cell lines (lcl). five of 9 hvp-transformed ct cell lines contained cells with antigens reacting with antibodies to epstein-barr virus (ebv) capsid antigen (vca) and/or to ebv-induced early antigens (ea). none of 12 wl lcl revealed such antigen-producing cells. cells from both groups of cultures failed to react with antibodies to the ebv-spec ... | 1977 | 197025 |
| productive epstein-barr viral infection of the human lymphoblastoid cell line 6410 with release of early antigen inducing and transforming virus. | the human lymphoblastoid cell line 6410 was superinfected with p3hr-1 derived epstein-barr virus. subsequent to the first cycle of infection, characterized by early (ea) and virus capsid (vca) antigen synthesis, the culture, designated 6410-ebv, continued to synthesize vca. further immunofluorescence and electron microscopic examination over 18-24 months showed the 6410-ebv culture to be productively infected with ebv. virus was recovered, in quantity, from the culture fluids and assayed for abi ... | 1977 | 197026 |
| cytotoxicity of circulating leukocytes in cytomegalovirus mononucleosis. | 1977 | 199389 | |
| infectious mononucleosis: recognition and management. | differentiation from other common viral infections depends on a triad of clinical, hematologic, and serologic determinations. a distinctive feature is that while a number of circulating immunoglobulins are often detected, only paul-bunnell antibodies, found in 75% of cases, are specific for im. symptomatic care only is indicated for most patients, though severe cases or complications may require antibiotics or corticosteroids. | 1977 | 196996 |
| a study of cytomegalovirus, epstein-barr virus and herpesvirus hominis (types 1 and 2) antibody in institutionalized and non-institutionalized children. | in an attempt to demonstrate differences in antibody prevalence between free-living and institutionalized children, antibodies to cytomegalovirus (cmv), epstein-barr virus (ebv), and herpesvirus hominis (hvh), types 1 and 2, were assayed in 123 children. the children comprised three groups consisting of 41 institutionalized patients with down's syndrome (all non-disjunctive trisomy-g karyotype and equal numbers of age-, sex-, and race-matched non-mongoloid institutionalized subjects and non-inst ... | 1977 | 199558 |
| unusual prevalence of epstein-barr virus early antigen (ebv-ea) antibodies in ataxia telangiectasia. | 1977 | 199670 | |
| virus infections after transplantation in man. brief review. | 1977 | 200197 | |
| clonal transformation of adult human leukocytes by epstein-barr virus. | we have developed a clonal transformation assay for epstein-barr virus which uses adult human leukocytes as target cells. the target cells were isolated from epstein-barr seronegative donors, and the same donor's cells could be studied repeatedly over long periods of time. when these cells were transformed by epstein-barr virus and had proliferated sufficiently to be studied, they had an average cloning efficiency of 3%. assuming this average cloning efficiency obtains at the onset of transforma ... | 1977 | 197258 |
| an immunological basis for inhibition of transformation of human lymphocytes by eb virus. | 1977 | 197426 | |
| the herpesvirus group. | several agents in the herpesvirus group are known to infect man. they cause a wide variety of conditions, ranging from coldsores to chickenpox and shingles. at the same time a number of the herpesviruses have been linked with malignant diseases in both lower animals and man. | 1977 | 198052 |
| a comparative study of human cell lines derived from patients with lymphoma, leukemia and infectious mononucleosis: membrane properties, ultrastructure, and surface morphology. | 1977 | 198097 | |
| solubilisation of epstein-barr virus (ebv)-associated nuclear antigen from raji cells and chromatin by treatment with various molarities of nacl. | the solubilisation of epstein-barr virus (ebv)-associated nuclear antigen (ebna) by treatment with various molarities of nacl was investigated using the 125i--igg absorption assay. ninety percent of the antigenic activity detected using the 125i--igg absorption assay was insoluble at 0.15 m nacl. it could be rendered soluble by treatment with 2.0 m nacl, but reprecipitated upon return to 0.15 m nacl. ebna was partially extracted from raji chromatin by treatment with 0.35 m nacl. the efficiency o ... | 1977 | 198113 |
| cellular immunodeficiency associated with nucleoside phosphorylase deficiency. immunologic and biochemical studies. | 1977 | 198175 | |
| epstein-barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties. | when sensitized leukocytes were re-exposed to ebv antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited ebv-induced transformation and ebv superinfection of target cells. unsensitized leucocytes from sero-negative adults and from neonates did not produce lymphokines when challenge ... | 1977 | 198380 |
| comparative studies on immunity to ebv-associated antigens in npc patients in north america, tunisia, france and hong kong. | this study compared the relative antibody titers to ebv-related antigens in patients with nasopharyngeal carcinoma (npc) and controls from a high-incidence (hong kong), an intermediate incidence (tunisia), and two low-incidence (france, north america) areas to determine which of several ebv antibodies best differentiated npc patients from controls. antibodies measured include anti-virus capsid antigen (vca), anti-early antigen (ea), anti-soluble antigen by complement-fixation (cf) and antibody-d ... | 1977 | 198381 |
| prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts. | the prevalence, incidence, and source of infections with different types of herpesviruses were determined prospectively for 25 persons undergoing hemodialysis, 30 allograft recipients, and 16 kidney donors. the prevalence of prior infections with cytomegalovirus (cmv), herpes simplex virus (hsv), and epstein-barr virus (ebv) was high (72%-100%) and was similar for healthy persons and those with renal failure. the incidence of infections in patients undergoing hemodialysis was no greater than tha ... | 1977 | 198488 |
| detection of soluble antigen of epstein-barr virus by the enzyme-linked immunosorbent assay. | the enzym-linked immunosorbent assay (elisa) was compared with the microcomplement-fixation test for sensitivity and reliability in detection of antibody to soluble antigen of epstein-barr virus. elisa was found to be more sensitive (up to 160 times more antibody) in detecting levels of antibody than the complement-fixation assay. the elisa test was shown also to be comparably reliable to the complement-fixation assay in detecting immunity to this antigen; only one false-positive response was fo ... | 1977 | 198494 |
| some factors affecting the expression of epstein-barr virus-associated membrane antigens. | the effect of two factors, l-arginine concentration and phytohemagglutinin (pha) stimulation, on the expression of epstein-barr virus (ebv)-associated membrane antigens (ma) was evaluated. an ebv-producer cell line, av-1, was cultivated in eagle's basal medium with earle's salts, supplemented with various l-arginine concentrations ranging from 0.0 to 20.0 mm. in most of the l-arginine concentrations, the number of cells expressing ma decreased within the first 24 hours. this decrease was followe ... | 1977 | 198561 |
| epstein-barr virus and nasopharyngeal carcinoma: is there an etiologic relationship? | antibody titers to all the epstein-barr virus (ebv)-related antigens were significant elevated (p less than 0.001) in patients with nasopharyngeal carcinoma (npc) compared with those of controls. ebv, early antigen, and anti-diffuse titers of chinese-american and black patients with npc were higher than those of white patients with npc. epstein-barr viral capsid antigen antibody titers were elevated in white patients with squamous cell carcinoma of the pharynx, regardless of subsite. these resul ... | 1977 | 198562 |
| [eb virus and infectious mononucleosis]. | 1977 | 200773 | |
| [factors involved in the development of human tumors using the epstein-barr virus as an example (author's transl)]. | several viruses induce tumors in animals under experimental or natural conditions. it is likely therefore that some human malignancies are also caused by viruses. proof of this hypothesis can be provided only by indirect evidence based on the following criteria: (1) detection of viral antigens or viral genetic information in a given tumor; (2) transformation of normal human cells by the virus in tissue culture; (3) induction of tumors in animals by the virus; and (4) demonstration of enhanced ti ... | 1977 | 198603 |
| establishment of a cell line with associated epstein-barr-like virus from a leukemic orangutan. | an epstein-barr virus like herpesvirus has been isolated from a lymphoid cell line derived from an orangutan with spontaneous myelomonocytic leukemia. herpesvirus has not previously been isolated from this species of higher ape. | 1977 | 198878 |
| [role of viral agents in the origin of hemoblastosis in primates]. | 1977 | 198991 | |
| relationship between the epstein-barr virus and undifferentiated nasopharyngeal carcinoma: correlated nucleic acid hybridization and histopathological examination. | in order to examine critically the closeness of association between epstein-barr virus (ebv) dna and nasopharyngeal carcinoma (npc) a correlated histopathological and nucleic acid hybridization study was performed on 51 undifferentiated npc, 4 npc with some signs of squamous differentiation, 7 nasophayngeal tumors of other histological types and 14 head and neck carcinomas located outside the nasopharynx. all 51 undifferentiated npcs contained significant numbers of ebv-genome copies per cell. t ... | 1977 | 199543 |
| cell mediated immunity during infectious mononucleosis to epstein-barr virus associated antigens. | twenty-three patients with recent infectious mononucleosis were studied for cell-mediated immunity to epstein-barr virus (ebv)-associated antigens. by means of a virion-containing antigen preparation, (p3j), leukocyte migration inhibition was demonstrated in 6 of 13 patients with acute infectious mononucleosis (im) and in 6 of 10 patients studied during the convalescent period. inhibition with a soluble antigen (s) preparation was seen in only a few patients at all stages of the illness. lymphoc ... | 1977 | 199544 |
| [role of the epstein-barr virus in human diseases]. | 1977 | 199027 | |
| the epidemiology of oral cavity, pharyngeal and esophageal cancer outside of north america and western europe. | geographical variations in the incidence of oral cavity, pharyngeal, and esophageal cancer were studied, with special reference to rates in countries outside of the united states and western europe. although reporting techniques differ greatly and comparisons must be made with caution, significant variations are evident. tracing such differences often reveals possible etiologic factor for these forms of cancer. the roles are discussed of known environmental carcinogens, such as n-nitroso compoun ... | 1977 | 198109 |
| infectious mononucleosis and fatal myocarditis. | mycocarditis is an uncommon manifestation and, very rarely, a lethal complication of infectious mononucleosis. a 14-year-old girl initially had exudative pharyngitis and splenomegaly and developed refractory ventricular fibrillation. the diagnosis of infectious mononucleosis was confirmed by both a strongly positive heterophil antibody test and a high titer of epstein-barr virus. pathologic studies demonstrated extensive histiocytic and lypmhocytic infiltration of the myocardium. | 1977 | 198186 |
| epstein-barr virus and cytomegalovirus antibodies in infectious mononucleosis. | a method has been evolved for the demonstration of epstein-barr virus (ebv) and cytomegalovirus (cmv) infection in 83 cases of infectious mononucleosis. serum samples were tested for ebv igm, anti-vca igg, anti-ebna, cmv igm and cmv igg antibodies. an acute-phase sample (or samples) and a convalescence sample were examined in each case, and in 44 cases an additional samples was examined 5-12 months after the illness. since the different antibodies showed characteristic differences in both titre ... | 1977 | 201153 |
| antibodies to epstein-barr virus capsid antigen and early antigen in nasopharyngeal carcinoma and comparison groups. | antibodies to epstein-barr virus capsid antigen (anti-vca) and early antigen (anti-ea) were measured in 263 patients with nasopharyngeal carcinoma (npc), 624 age- and sex-matched neighborhood controls, 570 family members of npc patients and 830 family members of neighborhood controls in taiwan. the distribution of antibody titers was significantly different between npc patients and the other three groups. more than 55% and 45% of npc patients had titers of greater than or equal to 1:640 and grea ... | 1977 | 199059 |
| viral particles in nasopharyngeal carcinoma. | lymphoepithelioma of the nasopharynx was identified in a 17-year-old chinese male. the epstein-barr virus titer was 1:3200. tissue from the tumor mass was prepared for electron microscopy. particles consistent with the morphological characteristics of herpes virus were found within the cytoplasm of malignant epithelial cells. this finding is discussed in relation to other data suggesting an oncogenic role of herpes virus in human malignancy. | 1977 | 199817 |
| multiple childhood osteosarcomas in an american indian family with erythroid macrocytosis and skeletal anomalies. | three of nine children of possibly consanguineous american indian parents developed typical osteosarcoma in a 2-year period. etiologic investigations detected limb anomalies and elevated mean corpuscular volumes (98--109 micrometer3) in the surviving tumor patient, several of her sibs, and her father. limb anomalies included simple clinodactyly with brachymesophalangy, absence of one digital ray of the foot, and bilateral radioulnar synostosis. the red cell macrocytosis was not accompanied by an ... | 1977 | 201363 |
| an italian case of nasopharyngeal carcinoma correlated with epstein-barr virus specific antigens. | an italian case of nasopharyngeal carcinoma was studied clinically; the immunologic study showed the correlation with the epstein-barr virus specific antigen. | 1977 | 201063 |
| primary epstein-barr virus infection in a renal transplant recipient. | a young girl with familial nephronophthisis and chronic renal failure contracted a primary epstein-barr virus infection after renal transplantation. during the illness she developed a clinical picture of fever and pneumonitis which closely resembled the posttransplantation syndrome usually associated with cytomegalovirus, although she had no evidence of cytomegalovirus infection. a younger sibling with the same renal disease was found retrospectively to have apparently had an earlier subclinical ... | 1977 | 199946 |
| alpha-l-iduronidase activity in established lymphoblastoid cells from patients with hurler and scheie syndromes transformed by epstein-barr virus. | alpha-l-iduronidase activity was determined in established lymphoblastoid cells, which were transformed in vitro by epstein-barr virus, of lymphocytes-rich cell populations isolated from peripheral blood of patients with hurler and scheie syndromes. alpha-l-iduronidase activities in established lymphoblastoid cells from patients were undetectable, while activities of control subjects were clearly detected. these results suggest that established lymphoblastoid cells are useful for the enzymatic s ... | 1977 | 199964 |
| histochemical studies on the ebv-determined nuclear antigen (ebna). | the ebv-determined nuclear antigen (ebna) was studied with regard to several histochemical properties. proteolytic enzymes destroyed ebna staining. rnase dnase and hyaluronidase had no effect on the number of ebna positive cells. intensive treatment with dnase weakened the chromosomal fluorescence of ebna, whereas the staining of interphase nuclei was relatively enzyme resistant. when ebv-associated soluble complement-fixing antigen of raji cells (cfa-r) was added to methanolacetic acid-fixed ch ... | 1977 | 200290 |
| [isoenzyme pattern of acid phosphatase in epstein-barr-virus-dna positive permanent growing lymphoid cell lines (author's transl)]. | the expression of acid phosphatases is cytochemically one of the most important features in permanent growing b-cell-lines. in few cell lines acid phosphatase is resistant against tartrate. tartrate resistant isoenzyme 5 with components a and b can be demonstrated in monocytes, lymphocytes, chronic lymphatic leucemic cells and especially in hairy cells as well as in cell lines derived from a healthy donor. fractionation of acid phosphatase by gelelectrophoresis in separated lymphocytes demonstra ... | 1977 | 200294 |
| nasopharyngeal cancer in patients under the age of thirty years. | there is evidence that patients under 30 years of age with nasopharyngeal cancer present a somewhat different form of disease than patients of the older age group. serum immunologic reactivity in the former was quantitatively different. histologically, tumors in the younger age group are always of the undifferentiated type, and clinically, the disease is aggressive, characterized by frequent bone and lung metastases. the lymphatic spread into the mediastinum is accompanied by a paraneoplastic sy ... | 1977 | 200338 |
| [herpes simplex virus (hsv-1 and hsv-2) infection: its clinical and oncogenic properties (author's transl)]. | the epidemiology and clinical features of diseases caused by the herpes simplex virus, are reviewed and recent results are discussed which give an insight into the complex mechanism of primary and chronic, recurrent hsv-1 infections. immunological reactions in hsv infection and data concerning the oncogenic potential of hsv-1 and -2 are dealt with. furthermore, current therapeutic possibilities are outlined. | 1977 | 201107 |
| [epidemiology of hodgkin's disease]. | 1977 | 200373 | |
| isolation of epstein-barr virus from cultured cells of a patient with hodgkin's disease. | the suspension lymphoblastoid cell line named chsl-1 was established from the tumor node of a patient with hodgkin's disease. the cells of this culture produce a virus with morphological and physicochemical properties of herpes viruses. immunologic study of the isolated virus demonstrated great similarity with the epstein-barr virus (ebv). | 1977 | 200451 |
| congenital infection with cytomegalovirus and epstein-barr virus. | 1977 | 201355 | |
| isolation of infectious eb virus from the epithelial tumour cells of nasopharyngeal carcinoma. | evidence of herpesvirus replication has been found by light and electron microscopy in the malignant epithelial cells of two out of six nasopharyngeal carcinomas (npc) examined directly after growth in nude mice to eliminate non-malignant infiltrating cells. the agent has been identified as eb virus by immunofluorescence tests for eb virus capsid antigen, and has been shown to be biologically active by its ability to infect and transform foetal cord blood lymphocytes. lymphoblastoid cell lines w ... | 1977 | 200568 |
| nasopharyngeal carcinoma: significance of changes in epstein-barr virus-related antibody patterns following therapy. | 1977 | 200569 | |
| [epstein-barr virus as an etiological factor in infectious mononucleosis and other diseases]. | 1977 | 201912 | |
| surface glycoprotein patterns of normal and malignant human lymphoid cells. ii. b cells, b blasts and epstein-barr virus (ebv)-positive and -negative b lymphoid cell lines. | 1977 | 200571 | |
| lymphocyte subpopulations and mitogenic responses in nasopharyngeal carcinoma, prior to and after radiotherapy. | eighteen patients with nasopharyngeal carcinoma (npc) were compared to matched controls, before or after cobalt therapy, for the ability of their peripheral blood lymphocytes to: (1) form e and eac rosettes and (2) mount a proliferative response with pha, con a and alg. a slight decrease in the percentage of e rosettes and a moderate hyporesponsiveness to pha and con a were observed before treatment. the statistical significance of these alterations was borderline. within the group of treated pa ... | 1977 | 200572 |
| persistent infection and viral carrier state of a human lymphoblastoid cell line infected with mumps virus before its transformation. | 1977 | 202295 | |
| epstein-barr virus, infectious mononucleosis, burkitt's lymphoma and nasopharyngeal carcinoma. | 1977 | 200586 | |
| human virus-infected target cells lacking hla antigens resist specific t-lymphocyte cytolysis. | 1977 | 200845 | |
| comparison of epstein-barr viral dnas in burkitt lymphoma biopsy cells and in cells clonally transformed in vitro. | the nucleotide sequences of intracellular epstein-barr viral dnas in tumor biopsy cells of clones independently transformed in vitro were generally compared by determing the electrophoretic mobilities of restriction endonuclease cleavage fragments of the viral dna. to carry out this comparison, cleaved cell dnas were electrophoresed in agarose gels and transferred to nitrocellulose paper, and the immobilized viral species were identified by hybridization with purified, viral dna labeled in vitro ... | 1977 | 200925 |
| epstein-barr virus genome carrying lymphocyte subpopulations of human palatine tonsils. | 1977 | 200950 | |
| viral attributes and host factors in carcinogenesis: herpesviruses. | this paper describes two different experiments of nature: 1) the persistence of unusual virus strains of epstein-barr virus (ebv) (which proved oncogenic in vitro) and cytomegalovirus (cmv) in lymphoid cells following congenital or early acquired infection; 2) the occurence of multiple cases of burkitt's lymphoma and nasopharyngeal carcinoma in one family. all the members of this family were ebv viral capsid antigen (vca) and nuclear antigen (ebna) antibody positive. the two patients with nasoph ... | 1977 | 200983 |
| transient induction of a nuclear antigen unrelated to epstein-barr nuclear antigen in cells of two human b-lymphoma lines converted by epstein-barr virus. | infection of cells of the epstein-barr virus (ebv)-negative human b-lymphoma lines bjab and ramos with ebv preparations from p3hr-1 or b 95-8 cells converted these cells to ebv genome carriers expressing epstein-barr nuclear antigen (ebna) in almost 100% of these cells. induction of these cells as well as of clones from p3hr-1 ebv-converted bjab cells with iododeoxyuridine, aminopterin, and hypoxanthine resulted in the appearance of a nuclear antigen in about 1-6% of the cells 1-4 days after ind ... | 1977 | 189313 |
| [igm diagnosis of epstein-barr virus (ebv) infections by means of the immunofluorescent method]. | sera were investigated of patients possibly suffering from an ebv infection, without showing clinical features characteristic of infectious mononucleosis. the method of investigation was the detection of antibodies of the igm-type by means of the immunofluorescent method using a three-layer technique. diagnosis of ebv infection was established in 10 out of 90 patients with facial palsy, one with myelitis, one with sudden deafness and one with polyneuritis. in addition, 4 out of 19 cases of hepat ... | 1977 | 189514 |
| prognosis of nasopharyngeal carcinoma by epstein-barr virus antibody titer. | a total of 433 samples of serum were collected from 305 patients with histopathologically proved anaplastic nasopharyngeal carcinoma (npc). antibodies against viral capsid antigens (vca) of epstein-barr (eb) virus were titrated by means of indirect fluorescent antibody technique, using p3hr-1 cells as the target. high anti-vca antibody titer in patients with npc was found beginning to decline at the end of radiotherapy. most (66.7%) of the patients were found to have a detectable reduction in an ... | 1977 | 189741 |
| infectious mononucleosis in children. evaluation of epstein-barr virus-specific serological data. | epstein-barr virus (ebv)-specific antibody responses were determined in 43 consecutive pediatric patients who had signs and symptoms of inectious mononucleosis (im) and positive diagnostic tests for mononucleosis (monspot). thirty patients gave clear-cut serologic evidence of primary ebv infections; of the remaining 13 patients, seven had no antibodies to ebv in the acute- or convalescent-phase sera and six showed serologic patterns of past ebv infections. further testing proved that the initial ... | 1977 | 189099 |
| elevated parainfluenza virus type 1 antibody in patients with subacute sclerosing panencephalitis. | parainfluenza virus hemagglutination inhibition (hi) antibodies were determined 3 times in the sera of 9 patients with subacute sclerosiing panencephalitis (sspe) and 20 healthy controls matched for age and place of residence. serum antibody against parainfluenza virus type 1 was significantly elevated in sspe patients as compared with controls, whereas antibodies against type 2 and 3 were found to be in normal ranges. higher titres of parainfluenza virus type 1 antibody might depend on: (1) dua ... | 1977 | 188993 |
| quantitative evaluation of epstein-barr-virus-infected mononuclear peripheral blood leukocytes in infectious mononucleosis. | we devised a quantitative assay for epstein-barr-virus-infected mononuclear leukocytes (virocytes) to determine their prevalence in the blood of patients with acute-phase and convalescent-phase infectious mononucleosis and in healthy epstein-barr-virus-seropositive controls. mononuclear peripheral blood leukocyte suspensions were tested for virus-determined cytoproliferative activity by cocultivation with human cord-cell indicator cultures. the highest levels of virocytes among circulating monon ... | 1977 | 187934 |
| [burkitt's lymphoma]. | 1977 | 189235 | |
| patterns of oropharyngeal eb-virus shedding. | 1977 | 187936 | |
| establishment in continuous culture of a new type of lymphocyte from a "burkitt like" malignant lymphoma (line d.g.-75). | the isolation and establishment in vitro of a hitherto undescribed type of lymphocyte designated d.g.-75 is reported. the original inoculum was derived from the pleural effusion of a child with a primary abdominal lymphoma, which clinically and histologically resembled burkitt's lymphoma. in addition to the absence of the ebv genome and ebv receptors, this line possesses a number of other properties which distinguish it from previously described lymphoblastoid cell lines. it has different growth ... | 1977 | 188769 |
| a case control study on immunity to two epstein-barr virus-associated antigens, and to herpes simplex virus and adenovirus in a population-based group of patients with hodgkin's disease in denmark, 1971-73. | one hundred and eighty-five patients with untreated hodgkin's disease (hd) comprising 86% of all new cases diagnosed in denmark over a 2-year period, were individually matched with healthy controls of the same age, sex, and social class. in comparison to controls, hd patients showed significantly elevated mean antibody titres to epstein-barr viral capsid antierences in mean titres were found for adenovirus common antigen. subdivision of the patients by age, sex, social class, hl-a antigens, stag ... | 1977 | 188770 |