immunovirologic assessment of american patients with nasopharyngeal carcinoma and occult primary tumors.the epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma, suggesting an etiologic relationship. we have under-taken studies (1) to quantitate the relationship between antibody titers to ebv-associated antigens and nasopharyngeal carcinoma in american patients since most of the patients in previous studies were of either asian or african descent and (2) to determine the relationship between antibody titers and the clinical course of the disease. sera from patients with pri ...1978224361
infectious up-to-date review of the clinical diagnostic and treatment of infectious mononucleosis, emphasizing on new etiological concepts (epstein-barr virus) and pathogenetic (t and b lymphocytes) interaction is presented.1979224362
infectious mononucleosis and encephalitis: recovery of eb virus from spinal fluid. 1979224373
diagnostic aspects of the cytomegalovirus mononucleosis syndrome in previously healthy persons.the mononucleosis-like syndrome due to cytomegalovirus (cmv) has many clinical features in common with classic epstein-barr virus (ebv) induced infectious mononucleosis (im). the hematologic and hepatic findings in both diseases are identical. diagnosis of the cmv-im syndrome usually can be made on the basis of indirect immunofluorescence for cmv macroglobulins (cmv-igm). ebv virologic tests may also be necessary, as patients with primary ebv infections may have cross-reactions at low titer in t ...1979224385
viral etiology of diseases of the hematopoietic system. 1979224431
a new approach to the study of human b lymphocyte function using an indirect plaque assay and a direct b cell activator. 1979224538
[burkitt's lymphoma. review and 4 danish cases]. 1979224544
analysis of early and late epstein-barr virus associated polypeptides by immunoprecipitation. 1979224588
enhancement of epstein-barr virus replication in producer cell lines by a combination of low temperature and corticosteroids. 1979224594
demonstration of ebna (epstein-barr virus nuclear antigen) antibodies of different immunoglobulin classes.anit-ebna igm, a previously unknown antibody, was detected by the antihuman globulin anticomplement immunofluorescence (acif) method in serum samples from acute infectious mononucleosis (im) of epstein-barr virus (ebv) origin. the antibody disappears from the serum in some weeks during convalescence. it was absent in anti-ebv=positive sera of healthy donors and in serum samples taken from patients with im caused by cytomegalo-virus. the antibody appears simultaneously with anti-ebv igmm and, rea ...1978224651
infectious mononucleosis test performance on cap survey specimens.the participant performances on 1977 and 1978 infectious mononucleosis survey specimens are tabulated. the various methods utilized gave similar results on negative specimens. commercial reagent kits incorporating differential absorption performed somewhat better on positive specimens than kits without differential absorption. many of the commercial reagent kits performed very poorly on the false postitive specimen.1979224693
etiology of liver disease in renal-transplant patients.the etiology of 72 episodes of liver disease that developed in 62 of 162 renal-transplant recipients was evaluated. infection with hepatitis b virus was a minor problem, and none of our patients had evidence of infection with hepatitis a. cytomegalovirus infection was ubiquitous in the population and probably accounted for many episodes of acute liver disease. this agent's role in causing chronic hepatitis is less secure. infections with other viruses including epstein-barr virus, adenovirus, an ...1979224742
[viruses, virus-like and virus-related structures in nasopharyngeal carcinoma (author's transl)].five cases of nasopharyngeal carcinoma with typically elevated eb-virus-antigen-titer were studied by light- and electron microscopic methods. within the cytoplasm corona viruses in different forms, regular capsid-like particles with a diameter of 60 nm, tubuloreticular aggregates, and pathologic alterations of the membranes of the endoplasmatic reticulum could be found. the nuclei of the tumour cells often showed particles within the nucleoplasm with an average diameter of 100 nm containing a c ...1979224851
search for human tumour viruses by transfection: uptake of melanoma and epstein-barr virus dna by human a model system, consistent transfection of chick embryo fibroblasts (cef) by dna from the xc cell line occurred, with recovery of infectious rous sarcoma virus. the techniques were then applied in attempts to recover possible human tumour viruses. even with various modifications of the xc technique, dna from three human malignant melanoma cell lines failed to infect adult or foetal human fibroblasts, although melanoma dna was taken up into nuclei of target cells. xc dna did not transfect huma ...1979224852
in vitro transforming activity of epstein-barr virus (ebv). ii. differences between m81 and b95-8 ebv strains.lymphocytes from 38 human cord blood and 9 adult circulating blood were aliquoted and infected in parallel either with the b95-8 ebv strain (produced by cotton-top marmoset lymphocytes transformed by ebv originating from an infectious mononucleosis line) or with the m81 eb virus (produced by callithrix jacchus marmoset lymphocytes transformed by ebv originating from a nasopharyngeal carcinoma (npc) derived line). significant differences were observed in the lymphoblastoid lines obtained and invo ...1979224964
histopathology of nasopharyngeal carcinoma: correlations with epidemiology, survival rates and other biological characteristics.a total of 363 cases of nasopharyngeal carcinoma (npc) in singapore were classified into squamous cell carcinoma (scc; 73 cases), non-keratinizing carcinoma (nkc; 178 cases) and undifferentiated carcinoma (uc; 172 cases). possible biological differences between these histologic types and between tumors with and without lymphocytic infiltration were investigated by correlations with survival rates and with selected epidemiologic, immunovirologic, and immunogenetic data on the disease. the 5-year ...1979225002
the structure of the termini of the dna of epstein-barr virus.we have studied the dna of epstein-barr virus (ebv) isolated from the b95-8 strain of that virus (miller and lipman, 1973). when ebv dna is partially digested with lambda-exonuclease and allowed to reanneal, up to 50% of the full-length molecules circularize. the arrangements of nucleotide sequences containing the terminal repeats identified in this circularization experiment have been determined. those fragments of viral dna generated by digestion with restriction endonucleases which are termin ...1979225039
the role of viral transformation and cytogenetic changes in viral oncogenesis.a wide variety of dna viruses and a more restricted family of rna viruses can transform normal cells in vitro. transformation means either immortalization and/or the appearance of certain phenotypic changes. although it has been often inferred that in vitro transformation can be essentially equated with malignant transformation, increasing evidence indicates that the latter, reflected by tumorigenicity in vivo, requires additional cytogenetic changes. the evidence will be reviewed for eb virus-a ...1979225148
elevated titer of antibodies to simian sarcoma virus envelope antigen (gp70) and normal response to influenza virus in untreated danish hodgkin's patients.untreated danish hodgkin's disease (hd) patients and paired age- and sex-matched controls were tested for serum antibodies to epstein-barr virus (ebv), six strains of influenza virus and simian sarcoma virus/simian sarcoma-associated virus [ssv(ssav)] antigens. hd sera showed significantly elevated titers against ebv and both increased incidence and mean titer of antibodies to the envelope glycoprotein of ssv(ssav), whereas testing against the influenza viruses revealed no differences between hd ...1979225281
growth of diploid, epstein-barr virus-carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions.human epstein-barr virus-carrying lymphoid cell lines which have been classified on the basis of studies on clonality and morphological, chromosomal and functional parameters as lymphoblastoid cell lines (lcl) of presumed non-neoplastic origin were inoculated intracerebrally into nude mice. all eighteen of them grew, killing the host mice within 7 to 25 days, except for 2 which grew more slowly. at autopsy, the brain of the nudes was found to be invaded by infiltrating lymphomas. sixteen of thes ...1979225282
epstein-barr mononucleosis in older persons. 1979225388
an unusual antibody response to epstein-barr virus during infancy. 1979225393
herpes simplex virus type 1 infection of isogenic epstein-barr virus genome-negative and -positive burkitt's lymphoma-derived cell lines.the epstein-barr virus (ebv) genome-negative burkitt's lymphoma-derived cell lines bjab and ramos and their in vitro ebv-converted sublines bjab-b1, bjab-a5, bjab-b95-8, and aw-ramos were infected with high multiplicities of herpes simplex virus type 1 (hsv-1; 10 to 70 pfu/cell). cultures were monitored for cell growth and hsv-1 dna synthesis. ebv-converted bjab cultures were more permissive for hsv-1 infection than bjab cultures. significant cell killing and hsv-1 dna synthesis were observed du ...1979225521
dna of epstein-barr virus. v. direct repeats of the ends of epstein-barr virus dna.previous data indicated that epstein-barr virus dna is terminated at both ends by direct or inverted repeats of from 1 to 12 copies of a 3 x 10(5)-dalton sequence. thus, restriction endonuclease fragments which include either terminus vary in size by 3 x 10(5)-dalton increments (d. given and e. kieff, j. virol. 28:524--542, 1978; s. d. hayward and e. kieff, j. virol. 23:421--429, 1977). furthermore, defined fragments containing either terminus hybridize to each other (given and kieff, j. virol. ...1979225546
dna of epstein-barr virus. vi. mapping of the internal tandem reiteration.epstein-barr virus (b95-8) dna consists of short (10 x 10(6)) and long (87 x 10(6)) unique dna sequences joined by 10 tandem reiterations of a 1.85 x 10(6) dna segment. the reiterated sequence contains bami and bglii sites separated by 4 x 10(5). the 4.5 x 10(5) and 14.0 x 10(5) segments generated by cleavage of the reiterated dna with bami and bglii contain sequences which hybridize to each other, suggesting that the internal tandemly reiterated sequence has a direct or inverted repeat within i ...1979225556
kawasaki disease without epstein-barr virus. 1979225579
cytotoxic effect of neocarzinostatin on human lymphoid cells.effect of a protein antitumor antibiotic, neocarzinostatin (ncs) was examined on epstein-barr virus (ebv)-carrying human lymphoid cell lines and normal human lymphocytes. a marked cytotoxic effect of ncs on umbilical cord lymphocytes freshly transformed by ebv was observed, whereas the cells before transformation were affected only very little by ncs. majority of long-term cultured cell lines were affected only slightly, while shorter-term cultured lines were more susceptible to the effect of nc ...1979225845
studies on an epithelial/burkitt hybrid cell line prepared from a lymphoblastoid cell line with one ebv genome equivalent per cell. 1979225868
[igg- and iga-antibodies to the epstein-barr virus in the sera of patients with nasopharyngeal carcinoma in cuba].sera from 24 patients with nasopharyngeal carcinoma (npc) and from 60 normal subjects were examined for the presence of igg and iga antibody to various antigens associated with epstein-barr virus (ebv). the results indicate that npc in cuba, like in other countries, was accompanied by high titers of ebv-specific igg antibody the levels of which differed markedly from those in normal subjects. serological activity of the patients differed depending on the stage of the illness and its duration. ge ...1979225887
[levels of humoral antibodies to epstein-barr virus in the population of cuba].indirect immunofluorescence was used to study the levels of humoral antibodies to capsid (vca) and early (ea) antigens of epstein-barr virus (ebv) in sera of 322 normal subjects living in the province of habana and varying in ages from several months to 93 years. the results suggest that the population of cuba, like in other countries, is widely infected with ebv, although the pattern of spread of this infection has some specific features. in particular, the infection rate of the pediatric popul ...1979225888
cells containing epstein--barr nuclear antigen (ebna) in peripheral blood.the anti-complement immunofluorescence (acif) method was used to demonstrate ebna in b lymphocytes separated from the peripheral blood of patients with infectious mononucleosis (im) or other diseases. in the acute phase of im of epstein-barr virus (ebv) origin, 0.5--1% of the b lymphocytes proved to be positive in 6 of the 8 patients tested. in two of the positive cases the test was repeated 20 and 26 days, respectively, after clinical symptoms had appeared; the result was negative in both cases ...1979225932
serum glycoproteins and immunoglobulins in nasopharyngeal carcinoma: correlations with epstein-barr virus associated antibodies and clinical tumor stage. 1979225960
membranous nephropathy. its association with multicentric angiofollicular lymph node hyperplasia.multicentric angiofollicular lymph node hyperplasia of the plasma cell type with systemic manifestations developed in a 51-year-old man. one year later, the nephrotic syndrome due to typical immune complex mediated membranous nephropathy developed. elevated titers to epstein-barr viral antigens suggesting reactivation of a latent infection were present. the patient has required conservative medical management only. the association of membranous nephropathy with angiofollicular lymph node hyperpl ...1979226028
rheumatoid factor as a cause of positive reactions in tests for epstein-barr virus-specific igm antibodies. 1979226299
[the epstein-barr virus, lymphoma and immunodeficiency state]. 1979226463
biological and biochemical observations on isolates of eb virus from the malignant epithelial cells of two nasopharyngeal carcinomas.foetal, adult seronegative, and cotton-top marmoset lymphocytes have been transformed into cell lines by eb virus from the malignant epithelial cells of two nasopharyngeal carcinomas. the nature of the cell lines was checked by karyotyping and by light and electron microscopy, and the presence of the eb virus genome was demonstrated by immunofluorescence tests. immunofluorescence also showed the incidence of eb virus-producing cells in each line and this was checked by electron microscopy and th ...1979226484
emergence of suppressor cells of immunoglobulin synthesis during acute epstein-barr virus-induced infectious mononucleosis. 1979226627
inhibition of the in vitro outgrowth of epstein-barr virus-infected lymphocytes by tg lymphocytes.human t lymphocytes subpopulations from subjects not acutely infected with ebv have been selected and examined for ability to inhibit the outgrowth of autologous b lymphocytes that have undergone in vitro infection with eb virus. the results show that only tg lymphocytes are inhibitory. tg lymphocytes from subjects who are ebv antibody-negative inhibit as well as those from subjects who have ebv antibody. tg lymphocyte populations, as well as other t cell fractions obtained from neonatal subject ...1979226628
cellular antiproliferative action exerted by auranofin.auranofin (af) is a new orally absorbed coordinated gold compound currently undergoing phase i studies for its use in the treatment of rheumatoid arthritis. our investigations with raji lymphoma, hela carcinoma, and ebv-transformed cells indicate af exerts an inhibitory effect on dna, rna, and protein synthesis as assessed by 3h-thymidine, 3h-uridine, and 3h-leucine uptake, respectively. a rapid and persistent dose dependent inhibition of 3h-thymidine uptake was observed at gold concentrations o ...1979226702
activation of suppressor t cells during epstein-barr-virus-induced infectious mononucleosis.infectious mononucleosis is caused by the epstein-barr virus (ebv), an unusual human pathogen because it preferentially infects b lymphocytes and consequently activates them to produce immunoglobulins. when cultures of lymphocytes from patients with infectious mononucleosis were stimulated with polyclonal activators, unseparated cells failed to produce immunoglobulins, whereas purified b cells responded normally. cocultures demonstrated profound suppressor t-cell activity in blood from patients ...1979226884
a virus-free immunogen effective against epstein-barr virus. 1979226890
a lymphoblastoid cell line from an adenosine deaminase deficient patient established by epstein-barr virus.lymphoblastoid cell lines from a patient with adenosine deaminase (ada) deficiency and his parents were established by epstein-barr virus (ebv). ada activity in the lymphoblastoid cells from the patient was not detectable, while the enzyme activity in the cells from his parents was approximately a half level of the controls'. no inhibitor to ada could be detected in the lymphoblastoid cells from the patient.1979227140
effect of 12-o-tetradecanoyl-phorbol-13-acetate on the replication of epstein-barr virus. i. characterization of viral dna. 1979227161
[production of lymphoid tumors in hamsters by direct implantation of human umbilical cord leukocytes. report i. production of lymphoid tumors and culture and their serial transplantation (author's transl)]. 1979227213
[production of lymphoid tumors in hamsters by direct implantation of human umbilical cord leukocytes. report ii. cell population analysis of the lymphoid tumors (author's transl)]. 1979227214
deoxyribonuclease activity found in epstein--barr virus producing lymphoblastoid cells.a deoxyribonuclease activity from epstein--barr (eb) virus producer lymphocyte cell lines which is correlated with viral production and which is not present in virus non-producer or negative lymphocyte cell lines has been purified 220-fold with 20% recovery and characterized. this nuclease copurifies through diethylaminoethylcellulose column chromatography with the eb virus induced deoxyribonucleic acid (dna) polymerase in eb virus producer cells which was recently reported by this laboratory, b ...1979227441
interaction of factors associated with cancer of the nasopharynx.a retrospective study of nasopharyngeal carcinoma (npc) revealed that smoking, working under poor ventilation, use of nasal balms or oil for nasal and throat troubles, use of herbal drugs, and anti-ebv antibody titer were found statistically associated. the dural interactions of these factors to the risk of npc were presented. except in work conditions with poor ventilation and when herbal drugs are used, all the combinations were synergistic. the synergistic actions were especially remarkable w ...1979227565
surface markers and size of lymphocytes in human umbilical cord blood stimulated into deoxyribonucleic acid synthesis by epstein-barr virus.we characterized subpopulations of lymphocytes in human umbilical cord blood which are stimulated into deoxyribonucleic acid synthesis by epstein-barr virus. lymphocytes were examined simultaneously for deoxyribonucleic acid synthesis by autoradiography and for surface markers by rosette formation with sheep erythrocytes or erythrocytes coated with antibody and mouse complement (eac). the subpopulation which incorporated [3h]thymidine after exposure to virus consisted mainly of cells which forme ...1979227794
relationship between epstein-barr virus genome number, amount of nuclear antigen, and early antigen inducibility in diploid and tetraploid lymphoma cells of related a collection of near-diploid and near-tetraploid raji sublines and somatic raji/raji hybrids a linear relationship was found between the number of epstein-barr virus (ebv) genome copies and the relative amount of ebv-determined nuclear antigen per cell. inducibility of the viral cycle by iododeoxyuridine and by p3hr-1 virus superinfection coulb be related to the number of resident ebv genome copies per haploid target cell. the implications of these findings are discussed.1979227812
epstein-barr virus-specific serum immunoglobulin a as an acute-phase antibody in infectious mononucleosis.immunoglobulin a (iga) antibodies to epstein-barr virus viral capsid antigen were assayed serially in 19 patients with infectious mononucleosis and in 38 controls. seventy-four percent of infectious mononucleosis patients demonstrated iga antibody, whereas this was found in 13% of controls. this antibody appeared early in infectious mononucleosis and was virtually gone 10 weeks after onset. comparison of iga antibody kinetics was made with igg and igm antibodies to viral capsid antigen, heteroph ...1979227922
detection of virus and cellular-determined antigens in situ using [125i]protein a and autoradiography.the present paper describes the use of [125i]protein a, isolated from staphylococcus aureus, in detecting antigen-antibody complexes by autoradiography on single cells. the method is relatively quick, reproducible, potentially more sensitive than immunofluorescence, and should be useful in combination with conventional radioimmuno-assays. we have used it to detect the cellular expression of igm, kappa, lambda, and beta 2-microglobulin, as well as the expression of epstein-barr virus (ebv)-associ ...1979227963
[diagnostic evaluation of anti-ebv(vca and ea) antibody titration in patients with nasopharyngeal carcinoma (author's transl)]. 1979228017
ebv specific killer t cells and serologic responses after onset of infectious mononucleosis. 1978228038
polypeptides of the epstein-barr virus membrane antigen complex.epstein-barr virus (ebv)-associated membrane antigens have been purified from the plasma membranes of the producer cell line p3hr-1 nono. the antigens were assayed with a specific rabbit anti-ebv antiserum using an 125i-labeled staphylococcal protein a binding assay. the antigens have been shown to be present on purified plasma membranes. treatment of the plasma membranes with triton x-100 allows the separation of two antigenically distinct classes of antigens, one soluble and one insoluble in t ...1979228070
[dynamics of peripheral white blood cell pattern in infectious mononucleosis]. 1979228501
[role of the epstein-barr virus in human pathology]. 1979228518
[epstein-barr virus and neoplasms]. 1979228519
persistent falsely positive rapid tests for infectious mononucleosis. report of five cases with four--six-year follow-up many laboratories, rapid slide tests incorporating differential absorption have replaced heterophil antibody tube tests in the investigation of suspect infectious mononucleosis. the present report describes serologic data from five individuals whose monospot tests remained falsely positive for four years or more without other evidence of infectious mononucleosis or underlying disease states. three of the five had never been infected with the epstein-barr virus. all five had negative results w ...1979228546
heterogeneity of epstein-barr virus. 1979228725
epstein-barr virus: structure of the viral dna and analysis of viral rna in infected cells. 1979228726
the relation between epstein-barr virus antibodies and clinical symptomatology and immunodeficiency in patients with hodgkin's disease.anti-epstein-barr virus (ebv) titers were measured in the sera of 37 patients with hodgkin's disease and in 40 normal controls. the patients were grouped according to histologic type, clinical symptomatology (relapse or remission), and their immune state (immunodeficient or non-immunodeficient). anti-epstein-barr nuclear antigens (ebna) and antiviral capside antigens (vca) titers were higher in patients with hodgkin's disease than in the controls. anti-ebna titers were significantly higher in pa ...1979228834
[on the problem of relationship between toxoplasmosis and eb virus infection (author's transl)]. 1979228853
increased sensitivity of new methods for detection of ebv antibodies and implications for infectious mononucleosis. 1979228889
epstein--barr virus-associated antibodies in igg and iga of nasopharyngeal carcinoma patients. 1979228890
the rescue of epstein--barr virus from primary cultured cells of nasopharyngeal carcinoma. 1979228891
dynamics of epstein--barr virus antibody titre in nasopharyngeal carcinoma. 1979228893
epstein--barr virus infection: seroepidemiology in various population groups of the greater montreal area. 1979228894
seroepidemiology of epstein--barr virus-associated diseases--i. a pilot evaluation using a radiometric quantitative complement fixation test. 1979228895
studies on nasopharyngeal carcinoma in the united states: a model for international comparisons. 1979228896
oncogenic herpesviruses of nonhuman primates. 1979228897
immunologic considerations in the selection of nonhuman primate models for studies of epstein--barr virus-associated diseases in man. 1979228898
a review of herpesvirus papio, a b-lymphotropic virus of baboons related to ebv. 1979228899
detection of the epstein-barr virus-associated antigens ea (early antigen) and vca (viral capsid antigen) by direct or indirect binding of iodinated antibodies to antigen immobilized in polyacrylamide gel. 1979228942
incidence of infectious mononucleosis at the universities of california and hawaii.the observed rates of heterophil-positive infectious mononucleosis at the university of california at davis and the university of hawaii at manoa were 1,212 and 37 per 100,000 students per academic year, respectively. the data collected suggest that the extraordinarily low incidence at the university of hawaii may be due to the following factors: (1) underutilization of the student health service by students with infectious mononucleosis; (2) low proportion of epstein-barr virus-seronegative stu ...1979229170
absence of allogeneic restriction in human t-cell-mediated cytotoxicity to epstein-barr virus-infected target cells. demonstration of an hla-linked control at the effector level.peripheral t lymphocytes from patients with infectious mononucleosis (im) are sensitized in vivo against the epstein-barr virus (ebv). the expression of hla-a, b, or c molecules at the target cell surface is necessary for the cytotoxic reaction because (a) ebv-positive daudi cells lacking hla-a, b, and c determinants are resistant to anti-ebv t-cell lysis, (b) cytolysis of ebv-positive target cells can be consistently inhibited by anti-hla-a, b, and c and anti-beta 2 microglobulin antibodies. ho ...1979229186
lymphocyte transformation induced by autologous cells. viii. impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis.the autologous mixed lymphocyte reaction (mlr) is severely impaired in patients with acute infectious mononucleosis. reactivity returned during the course of convalescence. the allogeneic mlr was not impaired in these patients. b cells from patients with infectious mononucleosis do not stimulate autologous t-cell proliferation, and this observation appears to explain the cellular basis of the impaired autologous mlr in infection. two explanations for the b-cell defect were considered: (a) the in ...1979229189
epstein-barr virus dna is amplified in transformed lymphocytes.leukocytes isolated from two adult donors who lacked detectable antibodies to antigens associated with epstein-barr virus were exposed to an average of 0.02 to 0.1 dna-containing particles of epstein-barr virus per cell and immediately clones in agarose. within about 30 generations all transformed cell clones contained between 5 and 800 copies of viral dna per cell. only 1 in 10(4) to less than 1 in 10(5) of the cells of each clone release virus, and the frequency of release did not correlate wi ...1979229241
immunochemical characterization of epstein-barr virus-associated early and late antigens in n-butyrate-treated p3hr-1 cells.sodium butyrate induces the epstein-barr virus cycle in latently infected p3hr-1 cells with a high efficiency. this fact was utilized for the metabolic labeling of the epstein-barr virus antigens. nonproducer raji cells, lacking both early antigen and viral capsid antigen, were used as controls. immunoprecipitation patterns were compared with 13 anti-epstein-barr virus (viral capsid antigen) - positive and 3 negative sera. sixteen polypeptides were identified as being associated with the lytic e ...1979229261
[burkitt-like lymphoma: diagnosis, clinical features, and response to chemotherapy (author's transl)].the burkitt-like lymphoma is extremely rare. it shows a predominance of presentation in abdominal and pelvic sites and an older median age as compared to the endemic burkitt's lymphoma. both are independent prognostic determinants and reflect a poor prognosis. this might be the reason for the low response rate to cytotoxic treatment. cyclophosphamide is a substantial part of any chemotherapeutic regimen used. serum lactic dehydrogenase (ldh) levels are closely correlated with the extent of tumor ...1979229308
effect of chloroquine on epstein-barr virus expression. 1979229421
severe neutropenia in infectious mononucleosis.mild neutropenia is a well-known concomitant of infectious mononucleosis caused by the epstein-barr virus (ebv) occurring in the first weeks of illness. however, severe neutropenia (less than 200 polymorphonuclear leukocytes per mul) is not generally regarded as a complication of infectious mononucleosis. three patients were seen with severe neutropenia and ebv infection, and an additional eight cases were found in the literature. in two of the latter cases the neutropenia was fatal. in the 11 c ...1979229647
the study of epstein--barr virus induction by cocultivation of ebv-transformed cells with a mammary carcinoma cell line mcf-7. 1979230055
guillain-barré syndrome associated with epstein-barr virus in a cytomegalovirus-negative patient.epstein-barr virus and cytomegalovirus have both been associated with guillain-barré syndrome after antibody investigations in several patients. in the teenage female patient in this present report, guillain-barré syndrome following infectious mononucleosis was associated with sero-conversion against epstein-barr virus but not cytomegalovirus. the findings are consistent with the hypothesis that epstein-barr virus might be an etiological agent for the guillain-barré syndrome and that infection w ...1979230116
eb virus-specific iga in serum of patients with infectious mononucleosis and of healthy people of different ages.the following sera were tested for eb virus-specific iga: serial sera from 61 cases of infectious mononucleosis (im) and from 195 ebv igg positive healthy students; single sera from each of 1469 persons of different ages, 63 cases of untreated hodgkin's disease, and 22 neonates. ebv specific iga was found in the sera from 88% of cases of im, from 18.5% of ebv igg positive healthy students, and in 13.5% of repeat samples from the same students three years later. the incidence of ebv iga varied fr ...1979230203
mode of integration of epstein-barr virus genome into host dna in burkitt lymphoma cells.the ebv dna integrated into the host genome from cell of an african burkitt lymphoma biopsy has been compared to the corresponding fraction of ebv dna from the cell line su-amb-2 which is of american burkitt lymphoma origin. it is shown that while, in the case of the african biopsy, large pieces of ebv dna sequences are integrated into the host dna, much smaller pieces of virus dna are integrated into the dna of the su-amb-2 cells. the possibility that this difference might be related to the fac ...1979230297
dunlop-dottridge lecture. rehumatoid arthritis, rheumatoid factor and the epstein-barr virus. 1979230349
burkitt's lymphoma cells: membrane properties and surface morphology as seen by scanning electron microscopy. 1979230393
comparison of membrane proteins of burkitt's lymphoma and ebv-transformed b lymphoblast cell lines and of con a-activated t lymphocytes and t lymphoblast cell lines. 1979230395
[enzyme induction by epstein-barr-virus-producing infection of lymphoblastoid cell lines].by means of biological in vitro assay collagenolytic activity of normal peripheral lymphocytes was compared to that of ebv-infected lymphoblastoid cell lines: the ebv-producing p3hr1 cells and the non-productive raji cells. while normal lymphocytes and raji cells revealed only traces of activity, significantly increased (p less than 0.001) collagenolytic activity was detected in samples of p3hr1, the cell-free ebv-suspension alone showed no collagenolysis. the described enzymatic activity was fu ...1979230436
[burkitt's lymphoma and epstein-barr virus]. 1979230462
antibodies to epstein-barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis.prior studies have shown that patients with seropositive rheumatoid arthritis (ra) have an increased frequency of precipitating antibody against a nuclear antigen, the ra nuclear antigen, detected in human b lymphoblastoid cell lines infected by epstein-barr virus. the present investigations demonstrate that patients with seropositive ra also have specifically elevated titers of antibodies to another, better-characterized epstein-barr virus-associated b cell antigen, the epstein-barr nuclear ant ...1979230491
human cell lines containing epstein-barr virus but distinct from the common b cell lymphoblastoid lines.a group of very similar cell lines was established from peripheral blood or bone marrow of 12 patients with a variety of disorders. the cells in these cell lines were uniform and round in shape. they grew as single-cell suspensions or as aggregates of small numbers of cells in stationary culture. the most striking characteristic of these lines was the lack of cells with surface immunoglobulin or with demonstrable immunoglobulin synthesis. this lack of immunoglobulin synthesis and their special g ...1979230517
human lymphocyte subpopulations. 1979230533
establishment of anti-tnp antibody-producing human lymphoid lines by preselection for hapten binding followed by ebv transformation.human lymphoblastoid cell lines that produce specific antibody against the hapten trinitrophenyl (tnp) have been established by selecting tnp-binding human b lymphocytes by tnp-rosetting and ficoll-isopaque separation, followed by epstein-barr virus (ebv) immortalization. derived lines secreted polyclonal anti-tnp antibodies and contained relatively small numbers of specific rosette- and plaque-forming cells against tnp-rbc. following rerosetting with tnp-rbc, the frequency of rosette-forming ce ...1979230581
hla-d typing with lymphoblastoid cell lines. vi. rationale and goals of data reduction.this report documents various characteristics of hla-d typing by mixed leukocyte culture reactions when lymphoblastoid cell lines (lcls) are substituted for peripheral blood lymphocytes as the stimulator cells. it also provides the rationale for designing the computer program described in the subsequent report. in such experiments, each donor to be hla-d typed is stimulated with a panel of 30-50 hla-d homozygous lcls, each defined hla-d allele being represented by several different human homogyg ...1979230611
epstein-barr virus infection in polytransfused patients with homozygous beta-thalassaemia.the frequency of epstein-barr virus (ebv) and hepatitis b virus (hbv) infection has been studied in 149 polytransfused thalassaemic patients and in healthy controls. evidence for ebv infection was based on the detection of antibodies to viral capsid antigen (anti-vca) and for hbv infection on the detection of either hepatitis b surface antigen (hbsag) or hepatitis b surface antibody (anti-hbs). the frequency of anti-vca was not significantly higher in the patients (16.4%) compared to the control ...1979230639
[juvenile infectious mononucleosis and epstein-barr virus infection]. 1979230659
vsv-inhibitor, interferon and anti-interferon activities in subacute and chronic viral infections. 1979230680
selective immunodeficiency and malignant lymphoma of the central nervous system. possible relationship to the epstein-barr virus.this report presents the findings of a study of a 17-year-old male with a selective immunodeficiency to the epstein-barr virus, who died of a malignant lymphoma following clinical infectious mononucleosis. autopsy findings and immunohistochemical techniques demonstrated a malignant lymphoma with b-lymphocyte characteristics which primarily involved the central nervous system (cns). the relationship of the epstein-barr virus to lymphoproliferation is discussed.1979230688
[comparative study of anti ebv antibodies in non-hodgkin's lymphomams and angio-immunoblastic lymphadenopathies (author's transl)].antibody titers to epstein-barr virus (ebv)--related antigens (viral capsid antigen : vca; early antigen : ea; and ebv associated nuclear antigen : ebna) were determined in the sera of 86 patients and 150 matched control subjects. the patients belonged to four histological groups : diffuse and nodular non-hodgkin's lymphomas angio-immunoblastic lymphadenopathies and apparented syndroms. the incidence of antibodies to other herpes-viruses (cytomégalovirus, herpes simplex virus, and varicella zost ...1979230873
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