equal hiv-1 decay kinetics in hsv-2-infected and hsv-2-uninfected clinical trial participants treated with antiretroviral therapy.herpes simplex virus-2 increases hiv-1 viral load and may augment hiv-1 transmission probability. to test the hypothesis that lower hiv-1 clearance rates in hsv-2-infected persons may account for this higher hiv-1 viral load, we studied 149 participants from 3 actg viral dynamic studies (a315, a5160s, and a5166s). though hiv-1 viral load was 0.19 logs higher in hsv-2-positive versus hsv-2-negative persons, first and second phase clearance rates during antiretroviral therapy were equal between pa ...201222330608
bioactivity-guided fractionation of phyllanthus orbicularis and identification of the principal anti hsv-2 compounds.the antiherpes virus properties of phyllanthus orbicularis kunth, a cuban-endemic medicinal plant, have been reported previously but data on its phytochemical profile and identification of antiviral metabolites as well as their mechanisms of action are still lacking. in this work, a bioactivity-guided phytochemical analysis was performed in order to isolate anti hsv-2 compounds. p. orbicularis contained mainly phenolic acids derivatives and flavonoids. the antiviral effects were attributed to (- ...201222318977
herpes simplex virus 2 infection rate and necessity of screening during pregnancy: a clinical and seroepidemiologic study.this study determined the seroprevalence of herpes virus 2 in gravidas and the differences between herpes virus 2-infected and healthy gravidas. the need to screen gravidas for herpes virus 2 was also evaluated.201222318830
live attenuated herpes simplex virus 2 glycoprotein e deletion mutant as a vaccine candidate defective in neuronal spread.a herpes simplex virus 2 (hsv-2) glycoprotein e deletion mutant (ge2-del virus) was evaluated as a replication-competent, attenuated live virus vaccine candidate. the ge2-del virus is defective in epithelial cell-to-axon spread and in anterograde transport from the neuron cell body to the axon terminus. in balb/c and scid mice, the ge2-del virus caused no death or disease after vaginal, intravascular, or intramuscular inoculation and was 5 orders of magnitude less virulent than wild-type virus w ...201222318147
exploiting the anti-hiv-1 activity of acyclovir: suppression of primary and drug-resistant hiv isolates and potentiation of the activity by ribavirin.multiple clinical trials have demonstrated that herpes simplex virus 2 (hsv-2) suppressive therapy using acyclovir (acv) or valacyclovir in hiv-1/hsv-2-infected persons increased the patient's survival and decreased the hiv-1 load. it has been shown that the incorporation of acv-monophosphate into the nascent dna chain instead of dgmp results in the termination of viral dna elongation and directly inhibits laboratory strains of hiv-1. we evaluated here the anti-hiv activity of acv against primar ...201222314523
mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a dna virus, but not by an rna virus.reactive oxygen species (ros) are crucial secondary messengers of signaling pathways. redox-dependent signaling events have been previously described in the innate immune response. however, the mechanism by which ros modulates anti-viral innate immune signaling is not fully clarified. here, we report that mitochondria-derived ros differentially regulate the innate response to dna and rna viruses (herpes simplex virus (hsv) and sendai virus (sev), respectively), with the cytokine response to hsv ...201222310710
recombinant cell lines expressing shrna targeting herpes simplex virus 2 vp16 inhibit virus establish hsv2 vp16 targeting shrna-expressing cell lines and investigate the antiviral effect of shrna targeting hsv2 vp16.201222286011
prolonged detection of herpes simplex virus type 2 (hsv-2) dna in cerebrospinal fluid despite antiviral therapy in a patient with hsv-2-associated radiculitis.herpes simplex virus type 2 (hsv-2) can cause radiculo-myelitis as a neurological manifestation. we report a case of ongoing hsv-2 dna positivity in the cerebrospinal fluid (csf) of at least eight weeks under antiviral therapy with acyclovir in a highly immunocompromised hemato-oncologic patient with hsv-2-associated radiculitis. upon admission, the patient presented with pain, leg paresis, and urinary incontinence, as well as pleocytosis in the csf. quantitative real-time pcr of the csf at day ...201222267477
prevalence and risk factors associated with herpes simplex virus-2 infection in a contemporary cohort of hiv-infected persons in the united states.we compared the herpes simplex virus type 2 (hsv-2) seroprevalence in a contemporary hiv cohort with the general us population and determined risk factors for hsv-2 infection among hiv-infected persons.201222249305
prevalence and concordance of hpv, hiv, and hsv-2 in heterosexual couples in kigali, the absence of prospectively collected transmission data, the transmission potential of a sexually transmissible infection (sti) can be estimated by its proxy of concordance in sexual partners. here we report concordance data of 3 viral stis: human papillomavirus (hpv), hiv, and herpes simplex virus type 2 (hsv-2) among heterosexual couples in kigali, rwanda.201222249302
sequential changes in pathophysiology of systemic inflammatory response in a disseminated neonatal herpes simplex virus (hsv) infection.disseminated neonatal herpes simplex virus (hsv) infection causes a typical systemic inflammatory response syndrome and has a high mortality rate. however, the validity of anti-inflammatory intervention against this condition remains unknown.201222237001
standard-dose and high-dose daily antiviral therapy for short episodes of genital hsv-2 reactivation: three randomised, open-label, cross-over and mucosal herpes simplex virus type 2 (hsv-2) shedding predominantly occurs in short subclinical episodes. we assessed whether standard-dose or high-dose antiviral therapy reduces the frequency of such shedding.201222225814
exploring the ethics of observational research: the case of an hiv study in tanzania.observational studies have generally been viewed as incurring minimal risk to participants, resulting in fewer ethical obligations for investigators than intervention studies. in 2004, the lead author (an) carried out an observational study measuring sexual behavior and the prevalence of hiv, syphilis, and herpes simplex virus type 2 (hsv-2), among tanzanian agricultural plantation residents (results reported elsewhere). this article uses an ethical lens to consider the consequences of the obser ...201224069546
meningitis retention syndrome.a 50-year-old caucasian woman presented with signs and symptoms of meningitis preceded by a 3 day history of flu-like symptoms and progressive difficulty with urination. cerebrospinal fluid (csf) analysis was consistent with aseptic meningitis. she was found to have a significant urinary retention secondary to atonic bladder. mri of the brain and spine were normal and csf-pcr (polymerase chain reaction) was positive for hsv-2. urinary retention in the context of meningitis and csf pleocytosis is ...201223882352
fulminant gestational hepatitis due to primary herpes simplex type 2 infection: use of serum hsv polymerase chain reaction for noninvasive diagnosis.acute gestational hepatitis from herpes simplex virus (hsv) infection is a rare but potentially life-threatening condition. we present the first reported case of primary hsv type 2 hepatitis in a pregnant woman who was diagnosed by detection of hsv-2 viremia via real-time polymerase chain reaction. the patient was successfully treated with acyclovir and delivered a healthy infant.201222104186
kyrieleis plaques associated with acute retinal necrosis from herpes simplex virus type present the case of a 19-year-old woman with acute retinal necrosis syndrome due to herpes simplex virus type 2, who developed segmental periarterial (kyrieleis) plaques six and one half weeks into her clinical course.201125390418
cutaneous lumbosacral herpes simplex virus among patients hospitalized for an advanced disease.cutaneous herpes simplex virus (hsv) infections are regularly observed in lumbosacral areas, and many are refractory to appropriate initial diagnosis and management.201221545541
frosted branch angiitis secondary to herpes simplex virus infection progressing to acute retinal describe a case of frosted branch angiitis secondary to herpes simplex virus type 2 infection that progressed to acute retinal necrosis.200925390834
production of high titre disabled infectious single cycle (disc) hsv from a microcarrier culture.disabled infectious single cycle (disc) hsv-2 has been cultured in the complimentary cell line cr2 to provide high titre bulk material suitable for the purification of the virus as a live viral vaccine. cr2 cells are cultured on the microcarrier cytodex-1 at 5 g l-1 in small scale (1 l) and larger scale (15 l) reactors. the cells are infected at an moi of 0.01 pfu cell-1 and the culture harvested 60-72 h later. the infected cells are removed from the microcarriers by the addition of a hypotonic ...199919003370
herpes simplex virus viremia during primary genital infection.primary genital herpes simplex virus (hsv) infection is commonly associated with systemic symptoms. a systematic evaluation of hsv viremia during primary genital infection has not been performed previously. plasma samples from adults with a first clinical episode of genital hsv infection were assayed for hsv dna by polymerase chain reaction. one hundred sixty-four adults had confirmed primary genital hsv infection. of these, 40 (24%) had hsv dna detected in plasma. thirty-seven (93%) of 40 were ...200818471083
herpes simplex virus colitis complicating ulcerative colitis: a case report and brief review on patients with inflammatory bowel disease herpes simplex virus infection has been described as a major cause of morbidity and mortality, especially in immunocompromised individuals. here we present the case of a 35-year old woman with an exacerbation of ulcerative colitis caused by herlpes simplex virus infection (hsv-2). the diagnosis was confirmed histologically following subtotal colectomy. after intravenous treatment with aciclovir for 2 weeks postoperative hematochezia stopped. herpes sim ...200721172183
valacyclovir therapy to reduce recurrent genital herpes in pregnant women.the purpose of this study was to estimate the efficacy of valacyclovir suppressive therapy in pregnant women with recurrent genital herpes.200616522412
glycoprotein d adjuvant herpes simplex virus vaccine.herpes simplex virus (hsv) type-1 and -2 are common infections that can cause primary and recurrent herpes labialis and genitalis, as well as gingivostomatitis, keratoconjunctivitis, encephalitis, disseminated infections in immunocompromised persons and neonatal infections. despite several decades of hsv vaccine development, no effective vaccine has been developed until recently. the following review of the genital hsv-2 glycoprotein d (gd2t, t is for truncated) subunit vaccine formulated with a ...200516221064
a randomized controlled trial of a replication defective (gh deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects.a replication incompetent herpes virus lacking the glycoprotein h gene has been developed as a potential therapeutic vaccine for genital herpes.200616213066
genital herpes complicating pregnancy.approximately 22% of pregnant women are infected with herpes simplex virus (hsv)-2, and 2% of women will acquire hsv during pregnancy. remarkably, up to 90% of these women are undiagnosed because they are asymptomatic or have subtle symptoms attributed to other vulvovaginal disorders. diagnosis of genital herpes relies on laboratory confirmation with culture or polymerase chain reaction assay of genital lesions and type-specific glycoprotein g-based serologic testing. neonatal herpes is the most ...200516199646
longitudinal analysis of herpes simplex virus-specific cd4+ cell clonotypes in infected tissues and blood.genital infection by herpes simplex virus (hsv)-2 offers a unique model for study of the effects of a remitting and exacerbating infection on the survival and persistence of antigen-specific t cells.200515897986
pediatrics and herpes simplex virus vaccines.this review explores the development of prophylactic genital herpes vaccines and their potential impact on perinatal and oral-facial disease. vaccine strategies have included the use of whole killed virus, viral subunits, attenuated live virus, viral vectors, and bare dna. to date, the recombinant subunit vaccine, truncated hsv-2 gd and alum/mpl, has been the most efficacious. the vaccine is 73 to 74 percent effective in preventing genital disease in herpes simplex virus seronegative women but i ...200515685147
diagnosis of genital herpes by real time pcr in routine clinical practice.virus isolation in cell culture is the recognised diagnostic gold standard for genital herpes. although increasing evidence indicates that polymerase chain reaction (pcr) provides a more rapid and sensitive diagnostic method, its implementation in routine diagnostic settings has been limited by concerns over contamination and cost.200415459412
preventing herpes simplex virus transmission to the neonate.neonatal herpes simplex virus (hsv) infection can have severe consequences. skin, eye and mouth infection is rarely fatal, but disseminated or central nervous system (cns) disease has a mortality rate of 80% in the absence of therapy, and most surviving infants have neurological sequelae. aciclovir therapy can improve the outcome of neonatal herpes, but is often delayed due to the early non-specific symptoms of the disease. even with early therapy, some infants develop disseminated infection or ...200415319088
[analysis on patial amino acid sequence of a novel glycoprotein binding to antiherpes simplex virus monoclonal antibody cha9].to acquire the characteristic amino acid sequence of a novel glycoprotein of herpes simplex virus (hsv), so as to localize gene encoding the novel glycoprotein accurately.200315155092
herpes simplex virus type 2 acute retinal necrosis in an immunocompetent report a case of acute retinal necrosis caused by herpes simplex virus 2 in an otherwise healthy patient.201728252688
neonatal herpes simplex virus infections.neonatal herpes simplex virus infections can result in serious morbidity and mortality. many of the infections result from asymptomatic cervical shedding of virus after a primary episode of genital hsv in the third trimester. antibodies to hsv-2 have been detected in approximately 20 percent of pregnant women, but only 5 percent report a history of symptomatic infection. all primary episodes of hsv and secondary episodes near term or at the time of delivery should be treated with antiviral thera ...200211925091
[alpha-herpes virus infections--male genital herpes].in japan, male genital herpes is the third popular male std, the most popular one being gonococcal infection and the second chlamydial infection. as specific clinical findings, superficial ulcer lesions with pain are formed in the genital area, especially in the prepuce. after hsv infection in genital mucocutaneous sites, viral particles are transported to the neurons. the state of subsequent hsv infection from external genitalia to the neurons is known as latent infection. 76% of our cases of t ...200010774209
neonatal herpes simplex virus infections.neonatal herpes simplex virus (hsv) infection is one of the life-threatening infections of newborns. it affects approximately 1,500 to 2,200 infants per year in the united states. changes in the presentation of neonatal hsv infection over the past two decades include an increase in the frequency of skin, eye, and mouth (sem) disease with a relatively unchanged rate of central nervous system (cns) disease, but a relative decline in disseminated infection. although the mortality of neonatal hsv in ...19989523400
recent advances in genital herpes.the majority of transmissions occur as a consequence of inapparent infection in the source contact, as asymptomatic viral excretion in individuals with recurrent infection. the development of type specific serological assays has allowed for a more accurate determination of herpes simplex virus (hsv) 2 prevalence and has revealed that the prevalence of hsv 2 in sexually transmitted disease clinic attenders varies from 8%-83%, in female prostitutes from 75%-96% and in antenatal clinic attenders fr ...19958849193
sp-303, an antiviral oligomeric proanthocyanidin from the latex of croton lechleri (sangre de drago).sp-303, a large proanthocyanidin oligomer isolated from the latex of the plant species croton lechleri (eupborbiaceae) has demonstrated broad activity against a variety of dna and rna viruses. in cell culture, sp-303 exhibits potent activity against isolates and laboratory strains of respiratory syncytial virus (rsv), influenza a virus (flu-a) and parainfluenza virus (piv). parallel assays of sp-303 and ribavirin showed comparable activity against these viruses. sp-303 also exhibits significant ...199423195881
necrotizing funisitis and herpes simplex infection of placental and decidual tissues: study of four cases.necrotizing funisitis (nf) is a macroscopically and microscopically distinctive pattern of umbilical cord inflammation recently heralded as presumptive of congenital syphilis. four nonsyphilitic cases are presented in which herpes simplex virus (hsv) 2 antigen was demonstrated in the placenta by immunohistochemistry. the clinicopathologic findings in one case, including hsv 2 antigen in amniotic epithelium, subamniotic chorion, and wharton jelly, indicate that nf was caused by chronic ascending ...19948026831
follow-up of pregnant women at high risk of transmitting herpes simplex virus.prospects for neonatal herpes transmission were studied in a group of pregnant chilean women at high herpetic risk--including 59 with a history of genital herpes, 11 with a first genital herpes episode during the observed pregnancy, and 16 whose sexual partners had a history of genital herpes. each woman completed a survey questionnaire, provided serologic samples for detection of herpes simplex virus (hsv), and provided periodic samples taken with cotton swabs for hsv isolation. the 86 women wh ...19948069336
herpes simplex virus infection of the fetus and newborn.although infrequent, untreated neonatal herpes results in death in half the cases and neurologic sequelae in three quarters of the survivors. neonatal infection is usually acquired from maternal genital herpes, which is asymptomatic or unrecognized in 60% to 80% of women. the greatest risk of neonatal infection occurs when the mother has primary genital herpes involving the cervix at delivery, and the infant is premature and delivered with instrumentation (eg, scalp electrodes). more than 80% of ...19948015861
[pemphigus vulgaris superinfected by herpes simplex virus ii in the absence of corticosteroid therapy]. 19911826364
evolution of post-natal herpes simplex virus encephalitis to multicystic encephalopathy.a 3-week-old, previously healthy infant developed biopsy-proven herpes virus type 2 (hsv-2) encephalitis. the encephalitis was characterized by cells having intranuclear inclusions and was without evidence of inflammation or hemorrhage. neuroimaging studies did not show any destructive lesions in the brain. in spite of antiviral therapy, the infant's neurological conditions deteriorated, and the patient died at the age of 18 weeks. post-mortem examination showed that most of the cerebral hemisph ...19901703387
acyclovir-resistant, foscarnet-sensitive oral herpes simplex type 2 lesion in a patient with aids.we report the case of an immunocompromised patient with aids in whom developed a perioral and several intraoral hsv 2 lesions that persisted for more than 1 year. the virus was resistant to acyclovir but was sensitive to foscarnet. viral isolates were thymidine kinase negative. the lesions resolved with intravenous foscarnet therapy given over a 15-week period, and when last seen, 8 months after foscarnet was discontinued, the patient had not had a recurrence.19892524706
epidemiology & clinical profile of genital herpes.during 1983-86, genital herpes (gh) was diagnosed in 225 (19%) of 1194 patients attending the std clinic, attached to a medical college in south india. the patients included 169 men and 56 women; 50 had primary gh and 175 had recurrent gh. the prevalence of gh in men and women did not differ significantly but the proportion of primary gh was significantly higher in women. there was no seasonal variation. the clinical epidemiology of these patients is compared with those in other countries. virol ...19892783686
effects of long-term acyclovir chemosuppression on serum igg antibody to herpes simplex virus.patients with severe or frequent recurrent genital herpes simplex virus (hsv) infection can be managed either by treating each recurrence with acyclovir or by suppressing recurrences with daily administration of the drug. to determine the effects of long-term acyclovir therapy on the immune response to hsv, we studied the change in igg antibody concentration to hsv in 46 individuals with recurrent genital hsv-2 infection who received acyclovir for 1 year, twenty-seven subjects received daily acy ...19883183633
[ulcerative herpes simplex virus ii esophagitis]. 19882831591
synthesis, structure, and biological activity of certain 2-deoxy-beta-d-ribo-hexopyranosyl nucleosides and nucleotides.2-deoxy-beta-d-ribo-hexopyranosyl nucleosides with adenine (2), hypoxanthine (17), guanine (23), cytosine (13), and uracil (7) as the aglycon were synthesized by the lewis-acid catalyzed condensation of an appropriate trimethylsilylated heterocyclic base and 2-deoxy-1,3,4,6-tetrakis-o-(4-nitrobenzoyl)-beta-d-ribo-hexopyranose+ ++ (5) to provide the desired beta anomers in good yield. when the synthesis of 7 via an sn2 displacement was attempted by reaction between silylated uracil and 2-deoxy-3, ...19873585903
detection of asymptomatic herpes simplex virus infections after vaccination.twenty-two volunteers seronegative for antibodies to herpes simplex virus (hsv) were enrolled in a trial to determine tolerance and immunogenicity of an hsv-2 glycoprotein subunit vaccine. vaccine was administered at days 0, 28, and 140, and sera were obtained on days 0, 7, 14, 21, 28, 35, 49, 56, 140, 147, and 365 for determination of hsv neutralizing antibody activity and antibody-dependent cell cytotoxicity (adcc). sera were also tested by immunoprecipitation of radiolabeled hsv-2-infected ce ...19873806788
intrauterine herpes simplex virus infections.neonatal herpes simplex virus (hsv) infection is usually acquired at birth, although a few infants have had findings suggestive of intrauterine infection. we describe 13 babies who had clinical manifestations of intrauterine hsv infection, including skin lesions and scars at birth (12), chorioretinitis (eight), microcephaly (seven), hydranencephaly (five), and microphthalmia (two). all infants had combinations of these defects. infection was proved by viral isolation in each case; all isolates w ...19873794894
a comparison of imaging, clinical, and pathologic aspects of space-occupying lesions within the brain in patients with acquired immune deficiency syndrome.patients with acquired immune deficiency syndrome (aids) often have central nervous system mass lesions. since clinical signs, symptoms, and results of imaging techniques are generally nonspecific, brain biopsy has been considered to be the optimal method for establishing a definitive diagnosis. in an effort to define better the imaging characteristics of such lesions, we retrospectively analyzed 24 patients with aids who had intracerebral space-occupying lesions, with subsequent definitive hist ...19863451758
prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. i. epidemiological determine the risk associated with previous herpes simplex type-2 (hsv-2) infection and possibly other virus infections, a prospective study of cervical neoplasia in more than 10,000 women was performed in the 1975-1983 period. the subjects were selected at random from an alphabetical listing of eligible women living in one district of prague. at enrollment colposcopy and cervical cytology were performed, a blood sample was taken and data regarding education, socio-economic status, personal h ...19846693194
a study of hla and drw antigens in severe recurrent herpes progenitalis (hsv-2) this preliminary study the phenotypic distribution of hla and drw antigens was investigated in patients with recurrent herpes progenitalis. ninety-three white men between the ages of 20 and 53 years, with at least a 2-year history of recurrent herpes progenitalis infection, and 558 age-matched white men from the same area of los angeles were studied by means of a microcytotoxicity assay. statistical analysis of data indicated that there is no increased incidence of any hla antigen. the b cell ...19826954168
herpes simplex virus diagnosis. antigen detection by elisa and flow microfluorometry.rapid diagnosis of herpes virus (hsv) infection is essential, primarily in the clinical management of the obstetrical patient. we developed an elisa procedure for viral antigen detection within 24 hours. the assay is sensitive and specific, detecting as little as 2 x 10(-3) micrograms antigen protein and reactivity with mock antigen or unrelated viruses (not observed). good (91.6%) correlation is observed between elisa and virus isolation. however, direct quantitative comparison indicates that t ...19826762291
[incidence of herpes virus (hsv-2) alterations in squamous cells of vagina epithelium (author's transl)].the authors have analysed 17,519 cytological cervix smears. alterations characteristic of hsv infection were recorded from squamous cells of vaginal and cervical epithelia in 21 cases (0.12 per cent). incidences of cytologically detected hsv infection of the vagina and cervix were 0.17 per cent among female factory workers and 0.08 per cent among peasant women. no statistically unambiguous difference was found to exist between the incidences of genital hsv infections in the two groups examined ( ...19817198853
herpes simplex virus (hsv) infection of organotypic nerve cell cultures. tubule-like structures in the nuclei of cells infected with type 2 but not with type 1 hsv-2 infected cultures, intranuclear tubule-like structures were found more commonly in fibroblasts and central nervous system (cns) neurons than in oligodendrocytes, astrocytes, satellite and schwann cells, but were found least often in peripheral neurons.1979525261
cervical cancer epidemiology in historical 1846, uterine cancer was the most frequently observed malignant tumor in western europe. it accounted for nearly 1/3 of all reported deaths in paris. the cervix was regarded as the primary source in most cases. several etiological theories in vogue today were discussed then. the relative infrequency of cervical cancer among jewish women was reported by numerous writers. the possible role of circumcision of husbands was not seriously considered until 1935. more recent such studies have been in ...19744599289
anti-cytokine autoantibodies in postherpetic neuralgia.the mechanisms by which varicella zoster virus (vzv) reactivation causes postherpetic neuralgia (phn), a debilitating chronic pain condition, have not been fully elucidated. based on previous studies identifying a causative role for anti-cytokine autoantibodies in patients with opportunistic infections, we explored this possibility in phn.201526482341
herpes viruses and human papilloma virus in nasal polyposis and controls.chronic rhinosinusitis with nasal polyps is a multifactorial disease entity with an unclear pathogenesis. contradictory data exist in the literature on the potential implication of viral elements in adult patients with chronic rhinosinusitis.201526480900
immunohistochemistry in the diagnosis of cutaneous viral infections--part i. cutaneous viral infections by herpesviruses and papillomaviruses.cutaneous viral infections are of increasing clinical importance, particularly in patients who are immunocompromised.201525171431
diversity and combinations of infectious agents in 38 adults with an infection-triggered reactive haemophagocytic syndrome: a multicenter study.reactive haemophagocytic syndrome (hs) is a rare condition that occurs in patients with infections, haematological malignancies or autoimmune diseases. although various microorganisms are thought to trigger hs, most of the literature data on this topic have been gathered in single-centre case series. here, we sought to characterize infectious triggers in a large, multicentre cohort of patients with hs. patients were included in the present study if hs was solely due to one or more infections. de ...201626686809
prevalence of viruses in stool of premature neonates at a neonatal intensive care unit.premature neonates represent a population highly vulnerable to infection. this study aims to profile viral colonisation of gut and the associated clinical manifestations among premature neonates admitted to a neonatal intensive care unit (nicu) in australia.201323432694
school-based sexual health education interventions to prevent sti/hiv in sub-saharan africa: a systematic review and sexual health education has the potential to provide an inclusive and comprehensive approach to promoting sexual health among young people. we reviewed evaluations of school-based sexual health education interventions in sub-saharan africa to assess effectiveness in reducing sexually transmitted infections and promoting condom use.201627724886
a randomized safety and pharmacokinetic trial of daily tenofovir 1% gel in term and near-term pregnancy.vaginal tenofovir (tfv) 1% gel may reduce incident hiv-1 and herpes simplex virus 2 infection. pregnancy may increase risk of hiv acquisition, and incident hiv in pregnancy potentiates perinatal hiv transmission. our objective was to investigate the safety and pharmacokinetics of seven days of tfv 1% vaginal gel in term and near-term pregnancy.201727658440
food insecurity is associated with hiv, sexually transmitted infections and drug use among men in the united examine the population-level association between food insecurity, hiv risk factors, and hiv serostatus among men, the group representing the majority of hiv diagnoses in the united states.201626990632
an empiric hiv risk scoring tool to predict hiv-1 acquisition in african develop and validate an hiv risk assessment tool to predict hiv acquisition among african women.201626918545
the incidence of trichomonas vaginalis infection in women attending nine sexually transmitted diseases clinics in the usa.trichomoniasis (tv) is associated with an increased risk of acquisition of sexually transmitted diseases (stds) and hiv. the purpose of this study is to evaluate factors associated with incidence tv among female std clinic attendees in the usa.201626071390
high hiv prevalence and incidence among msm across 12 cities in characterize prevalence, incidence, and associated correlates of hiv infection among msm in 12 cities across india.201525849835
laboratory-confirmed hiv and sexually transmitted infection seropositivity and risk behavior among sexually active transgender patients at an adolescent and young adult urban community health center.the sexual health of transgender adolescents and young adults who present for health care in urban community health centers is understudied. a retrospective review of electronic health record (ehr) data was conducted from 180 transgender patients aged 12-29 years seen for one or more health-care visits between 2001 and 2010 at an urban community health center serving youth in boston, ma. analyses were restricted to 145 sexually active transgender youth (87.3% of the sample). laboratory-confirmed ...201525790139
the role of human dendritic cells in hiv-1 infection.dendritic cells (dcs) and their subsets have multifaceted roles in the early stages of hiv-1 transmission and infection. dc studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the c-type lectins, langerin on langerhans cells (lcs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other dc subsets, limiting or facilita ...201525407434
sexual risk reduction interventions for hiv prevention among south african youth: a meta-analytic examine the efficacy of sexual risk reduction interventions among south african youth.201324476351
quantifying ongoing hiv-1 exposure in hiv-1-serodiscordant couples to identify individuals with potential host resistance to hiv-1.immunogenetic correlates of resistance to hiv-1 in hiv-1-exposed seronegative (hesn) individuals with consistently high exposure may inform hiv-1 prevention strategies. we developed a novel approach for quantifying hiv-1 exposure to identify individuals remaining hiv-1 uninfected despite persistent high exposure.201222926009
cervical screening within hiv care: findings from an hiv-positive cohort in women have an increased risk of invasive cervical cancer but cytologic screening is effective in reducing incidence. little is known about cervical screening coverage or the prevalence of abnormal cytology among hiv-positive women in ukraine, which has the most severe hiv epidemic in europe.201222545087
hiv-associated hypertrophic herpes simplex genitalis with concomitant early invasive squamous cell carcinoma mimicking advanced genital cancer: case report and literature review.hypertrophic herpes simplex genitalis (hhsg) is an uncommon anogenital manifestation of herpes simplex virus (hsv) infection in immunocompromised patients. to date, 24 cases of hhsg have been reported; 23 of them were affected human immune deficiency virus (hiv) type 1-positive patients. we describe the case of a 44-year-old african hiv-1-positive woman who presented with painful ulcerated nodular lesions of the vulva and perianal area measuring up to 7 cm in diameter. macroscopically, the lesio ...201222498948
recreational drug use: an emerging concern among venue-based male sex workers in china.a 2009 survey of 418 venue-based male commercial sex workers in shenzhen, china revealed that 19.9% used recreational drugs. consistent condom use by drug users was lower than that by nonusers. hiv, syphilis, and herpes simplex virus 2 prevalences were higher among drug users. prevention programs need to address drug use among male commercial sex workers in china.201222421689
intravaginal rings: controlled release systems for contraception and prevention of transmission of sexually transmitted infections.intravaginal rings (ivrs) are a dosage form used to locally or systemically deliver drugs in the vagina. they are capable of releasing one or more drugs over an extended period of time (from several weeks to a year or longer). contraceptive ivrs are currently gaining popularity due to the success of the contraceptive product nuvaring®. delivery of contraceptives from ivrs should promote compliance/adherence, and they also provide effective cycle control and symptom relief (menorrhagia, dysmenorr ...201125788239
dna vaccine encoding hpv16 oncogenes e6 and e7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives e7-expressing skin graft rejection.we have previously shown that a novel dna vaccine technology of codon optimization and the addition of ubiquitin sequences enhanced immunogenicity of a herpes simplex virus 2 polynucleotide vaccine in mice, and induced cell-mediated immunity when administered in humans at relatively low doses of naked dna. we here show that a new polynucleotide vaccine using the same technology and encoding a fusion protein of the e6 and e7 oncogenes of high-risk human papillomavirus type 16 (hpv16) is immunogen ...201728166181
pathway analysis of cervical cancer genome-wide association study highlights the mhc region and pathways involved in response to infection.cervical cancer is caused by infection with human papillomavirus (hpv). a genome-wide association study (gwas) has identified several susceptibility loci for cervical cancer, but they explain only a small fraction of cervical cancer heritability. other variants with weaker effect may be missed due to the stringent significance threshold. to identify important pathways in cervical carcinogenesis, we performed a two-stage pathway analysis in two independent gwass in the swedish population, using t ...201424934695
sexuality and sexual health: constructs and expressions in the extended middle east and north africa.the extended middle east and north africa (emena) region is the world region with the second youngest population, where globalization, migration, information technology, and political changes are contributing to the shaping of sexuality and sexual behaviors. understanding the various sociocultural, demographic and public health dimensions of sexual and reproductive health of young people is fundamental to understanding the pattern of sexual behavior and the burden of sexually transmitted infecti ...201324331819
antimicrobial and cytotoxic activities of turbinariaconoides (j.agardh) kuetz.brown alga, turbinariaconoideswas successively extracted with n-hexane, cyclohexane, methanol and ethanol:water (1:1). the extracts were evaluated for antibacterial and antifungal activities by disc diffusion method. minimal inhibitory concentration was determined for active extracts by broth dilution method. the antiviral activity and cytotoxicity of the extracts were tested in human embryonic lung (hel) cells (herpes simplex virus-1, herpes simplex virus-2, vaccinia virus, vesicular stomatitis ...201024381606
effects of a traditional chinese medicine, longdanxiegan formula granule, on toll-like receptor pathway in female guinea pigs with recurrent genital herpes.the aim of the present study was to investigate the effects of longdanxiegan formula granule (ldxgfg), a chinese traditional medicine on toll-like receptor (tlr) pathway in recurrent genital herpes.201627125405
pregnancy outcomes in association with stds including genital hsv-2 shedding in a south african cohort study.genital herpes simplex virus-2 (hsv-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes.201728396556
an intravaginal ring that releases three antiviral agents and a contraceptive blocks shiv-rt infection, reduces hsv-2 shedding, and suppresses hormonal cycling in rhesus macaques.women globally need access to multipurpose prevention technologies (mpts) that prevent human immunodeficiency virus (hiv), sexually transmitted infections that increase hiv acquisition/transmission risk, and unintended pregnancy. seeking an mpt with activity against hiv, herpes simplex virus-2 (hsv-2), and human papillomavirus (hpv), we developed a prototype intravaginal ring (ivr), the mzcl ivr, which released the antiviral agents miv-150, zinc acetate, and carrageenan (mzc for short) and the c ...201728600625
hsv-1/hsv-2 infection-related cancers in bantu populations driving hiv-1 prevalence in africa: tracking the origin of aids at the onset of the 20th the onset of the 20th century, ancient clinical observations of cancer epidemics in bantu populations of sub-saharan africa were discovered. they were reported from 1914 to 1960, but remained unexplained. in 1983, in san francisco, calif., usa, cancer epidemics were related to infections by the human immunodeficiency virus type 1 (hiv-1) known as aids disease. yet since 1996, it is known that hiv-1 strains are not the only ones involved. in sub-saharan africa, recurrent orobuccal herpes simpl ...201728413399
prevalence and risk factors of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in papua new guinea: a cross-sectional survey.background papua new guinea (png) is estimated to have among the highest prevalences of hiv and sexually transmissible infections (stis) of any asia-pacific country, and one of the highest burdens of maternal syphilis globally. the prevalence of curable stis, such as chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv), among pregnant women in png is relatively unknown.201628636866
patterns of prevalent hpv and sti co-infections and associated factors among hiv-negative young western cape, south african women: the evri estimate the prevalence and describe the patterns of concurrent human papillomavirus (hpv) and stis and associated factors among hiv-negative young western cape, south african women participating in the efficacy of hpv vaccine to reduce hiv infection (evri) trial.201728490581
results of real-time multiplex polymerase chain reaction assay in renal transplant recipients with sterile pyuria.urinary tract infections are a major cause of morbidity and hospitalization after renal transplantation. patients treated with immunosuppressive drugs suffer not only from common uropathogens but also from opportunistic infections caused by unusual uropathogens. sterile pyuria is associated with numerous infectious agents including viruses, fungi, and atypical or fastidious organisms. the objective of this study was to investigate the pathogens using real-time multiplex polymerase chain reaction ...201728735999
distinct effects of the cervicovaginal microbiota and herpes simplex type 2 infection on female genital tract immunology.genital inflammation is a key determinant of human immunodeficiency virus (hiv) transmission, and may increase hiv-susceptible target cells and alter epithelial integrity. several genital conditions that increase hiv risk are more prevalent in african, caribbean, and other black (acb) women, including bacterial vaginosis and herpes simplex virus type-2 (hsv-2) infection. therefore, we assessed the impact of the genital microbiota on mucosal immunology in acb women and microbiome-hsv-2 interactio ...201728201724
human infectious diseases and risk of preeclampsia: an updated review of the literature.preeclampsia (pe) is one of the major causes of maternal and perinatal morbidity and mortality, especially in low- and middle-income countries. in recent years, a growing body of literatures suggests that infections by bacteria, viruses, and parasites and their related inflammations play an important role in the pathogenesis of pe.201728577241
the efficacy of epigallocatechin-3-gallate (green tea) in the treatment of alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice.alzheimer's disease (ad) is a neurodegenerative disorder and the most common form of dementia characterized by cognitive and memory impairment. one of the mechanism involved in the pathogenesis of ad, is the oxidative stress being involved in ad's development and progression. in addition, several studies proved that chronic viral infections, mainly induced by human herpesvirus 1 (hhv-1), cytomegalovirus (cmv), human herpesvirus 2 (hhv-2), and hepatitis c virus (hcv) could be responsible for ad's ...201728642806
acute recurrent lymphocytic meningitis in an immunocompetent hiv-positive african woman: is it a mollaret's meningitis or not?we report a case of acute recurrent meningitis in an hiv-positive immunocompetent woman. in this case, a 34-year-old african woman with a known hiv infection presented with symptoms of acute meningitis. she was on combination antiretroviral therapy with abacavir, lamivudine, and nevirapine. her hiv rna level was <70 iu/ml, and cd4 counts were 640 cells/mm(3). this indicates that she was not immunocompromised. she was febrile on examination, with marked neck stiffness. her cerebrospinal fluid rev ...201728835824
herpes simplex virus 1 and 2 educational assessment of young adults in rural southwest virginia.herpes simplex virus 2 (hsv-2) causes genital herpes, one of the most common sexually transmitted infections (stis) in the u.s. hsv-1, commonly associated with cold sores, is increasing as a cause of genital herpes. abstinence-only sexual health classes, commonly taught in virginia, generate young adults who are under-educated in sexual health, increasing sti risks. college students in southwest virginia were surveyed to assess comprehensiveness of high school health education regarding hsv-1 an ...201728654651
latent virus reactivation in astronauts on the international space station.reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight onboard the international space station . twenty age-matched and sex-matched healthy ground-based subjects were included as a control group. blood, urine, and saliva samples were collected before, during, and after spaceflight. saliva was analyzed for epstein-barr virus, varicella-zoster virus, and herpes simplex virus type 1. urine was a ...201728649633
[evaluation of viral etiology in central nervous system infections from a university hospital point of view in izmir based on seven years data].the serious diseases of the central nervous system (cns); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. nucleic acid testing (nat) is the tool of choice for viral diagnosis in cns infections. in this study, viral etiological agents found in cerebrospinal fluid (csf) samples sent to our university hospital virology laboratory for laboratory diagnosis of cns infections were retrospectively evaluated and results were compared with ...201728566076
capacitive dna sensor for rapid and sensitive detection of whole genome human herpesvirus-1 dsdna in serum.this work presents a rapid, highly sensitive, low-cost, and specific capacitive dna sensor for detection of whole genome human herpesvirus-1 dna. this sensor is capable of direct dna detection with a response time of 30 s, and it can be used to test standard buffer or serum samples. the sensing approach for dna detection is based on alternating current (ac) electrokinetics. by applying an inhomogeneous ac electric field on sensor electrodes, positive dielectrophoresis is induced to accelerate dn ...201728328089
[erythema exudativum multiforme--case report].erythema exudativum multiforme (em) is an acute mucocutaneous disease. etiology of this disease is not clear. 50% - 60% cases of em is induced by hsv infection (herpes simplex virus 1, herpes simplex virus 2). em lesions may appear as red macules, erosions, ulcerations and hemorrhagic crusts. the study describes the case of 22 - year - old male who had characteristic lesions for em after hsv infection.201526817344
the "knife-cut sign" revisited: a distinctive presentation of linear erosive herpes simplex virus infection in immunocompromised patients.the "knife-cut sign" is a distinctive presentation of linear erosive herpes simplex virus infection in immunocompromised patients.201526557219
[the lysate and recombinant antigens in elisa-test-systems for diagnostic of herpes simplex].the lysate and recombinant antigens of various production included informula of elisa-test-systems were analyzed. the elisa-test-systems are used for detection of igg to herpes simplex virus type i and ii. for testing the panel of serums pth 201 (bbi inc.) were used. the samples of this panel contain antibodies to herpes simplex virus type i and ii in mixed titers. the 69 serums of donors were used too (17 samples had igg to herpes simplex virus type i, 23 samples to herpes simplex virus type ii ...201425552056
isolation and characterization of a novel alphaherpesvirus in fruit bats.bats are known to harbor emerging rna viruses. recent studies have used high-throughput sequencing technology to identify various virus species, including dna viruses that are harbored by bats; however, little is known about the nature of these potentially novel viruses. here, we report the characterization of a novel herpesvirus isolated from an indonesian pteropodid bat. the virus, tentatively named fruit bat alphaherpesvirus 1 (fbahv1), has a double-stranded dna genome of 149,459 bp. the phyl ...201424942567
comparison of acyclovir and multistrain lactobacillus brevis in women with recurrent genital herpes infections: a double-blind, randomized, controlled study.we performed a randomized double-blind controlled trial to compare the efficacy and safety of multistrain probiotic and acyclovir in women patients with recurrent genital herpes simplex virus type 2 (hsv-2) infections. eighty-one patients enrolled in the study were being treated with multistrain lactobacillus brevis one vaginal capsule every 12 h and oral acyclovir 400 mg twice daily for 6 months. of 53 patients who completed both treatment courses, no important differences were identified betwe ...201728852985
a herpes simplex virus type 2 deleted for glycoprotein d enables dendritic cells to activate cd4(+) and cd8(+) t cells.herpes simplex virus type 2 (hsv-2) is highly prevalent in the human population producing significant morbidity, mainly because of the generation of genital ulcers and neonatal encephalitis. additionally, hsv-2 infection significantly increases the susceptibility of the host to acquire hiv and promotes the shedding of the latter in the coinfected. despite numerous efforts to create a vaccine against hsv-2, no licensed vaccines are currently available. a long-standing strategy, based on few viral ...201728848543
effect of hsv-2 infection on subsequent hiv acquisition: an updated systematic review and and herpes simplex virus type 2 (hsv-2) infections cause a substantial global disease burden and are epidemiologically correlated. two previous systematic reviews of the association between hsv-2 and hiv found evidence that hsv-2 infection increases the risk of hiv acquisition, but these reviews are now more than a decade old.201728843576
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