Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| effectiveness of early antiviral therapy in disseminated neonatal herpes simplex virus 2 (hsv-2) with fulminant hepatic failure. | background liver failure in the neonatal population is a life-threatening complication and has a wide array of etiologies, including infectious, immune-mediated, metabolic, or drug-induced. although neonatal herpes simplex virus (hsv) hepatitis only accounts for 1% of all acute liver failures, it has an extremely aggressive clinical course that carries a mortality rate of 85%. case report we report a rare case of disseminated neonatal hsv-2 with late presentation associated with fulminant liver ... | 2017 | 28392553 |
| low cd4 cells and viral co-infection increase the risk of vain: use of scca1 and ki67 as diagno-prognostic biomarkers. | this study evaluated the correlation of scca1, ki67 and cd4 cell expressions and classified vaginal smears in individuals co-infected with human immunodeficiency virus (hiv), herpes simplex virus 2 (hsv2), epstein barr virus (ebv) and human papilloma virus (hpv). this crossectional study included 173 participants within the age range of 20-70 years. vaginal smears were stained by papanicolaou technique and classified into high-grade squamous cell intraepithelial lesion (hsil), low-grade squamous ... | 2017 | 29269193 |
| a herpes simplex virus type 2-encoded microrna promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer. | certain viruses use micrornas to regulate the expression of their own genes, host genes, or both. a number of micrornas expressed by herpes simplex virus type 2 have been confirmed by previous studies. however, whether these micrornas play a role in the metastasis of lung cancers and how these viral micrornas precisely regulated the tumor biological process in lung cancer bone metastasis remain obscure. we recently identified the high expression of an acutely and latently expressed viral microrn ... | 2017 | 28468588 |
| the role of fungi in the etiology of multiple sclerosis. | multiple sclerosis (ms) is a chronic inflammatory disorder of the central nervous system. infectious triggers of ms are being actively investigated. substantial evidence supports the involvement of the epstein-barr virus (ebv), though other viruses, bacteria, protists, and fungi are also being considered. many links between fungi and diseases involving chronic inflammation have been found recently. evidence linking ms and fungi is reviewed here. the hla-drb1*15 allele group is the most important ... | 2017 | 29085329 |
| [investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods]. | in this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (pcr) methods. patients hospitalized with central nervous system infections between april 2012 and february 2014 were enrolled in the study. demographic and clinical information of the patients were collected prospectively. cerebrospinal fluid (csf) samples of the ... | 2017 | 28929964 |
| determining the igm and igg antibodies titer against hsv1, hsv2 and cmv in the serum of schizophrenia patients. | schizophrenia is a destructive clinical syndrome with diverse mental pathologies. different mechanisms and factors have a role in this disease. a possible mechanism is that teratogenic viruses cause brain changes and results in the disease appearance. the schizophrenia patients were diagnosed by psychologists and with the consent of patients, five cc of venous blood was drawn. than serum samples were isolated and immunoglobulin m (igm) and immunoglobulin g (igg) antibodies against herpes simplex ... | 2017 | 29036805 |
| herpesviruses in etiopathogenesis of aggressive periodontitis: a meta-analysis based on case-control studies. | previous studies have found that herpesviruses are associated with aggressive periodontitis (agp). however, these findings are controversial. this meta-analysis was aimed at clarifying the association between herpesviruses and agp. | 2017 | 29036216 |
| erratum to: precision of the kalon herpes simplex virus type 2 igg elisa: an international inter-laboratory assessment. | 2017 | 28525965 | |
| racial/ethnic disparities at the end of an hiv epidemic: persons who inject drugs in new york city, 2011-2015. | to examine whether racial/ethnic disparities persist at the "end of the hiv epidemic" (prevalence of untreated hiv infection < 5%; hiv incidence < 0.5 per 100 person-years) among persons who inject drugs (pwid) in new york city. | 2017 | 28520494 |
| sexual network drivers of hiv and herpes simplex virus type 2 transmission. | hiv and herpes simplex virus type 2 (hsv-2) infections are sexually transmitted and propagate in sexual networks. using mathematical modeling, we aimed to quantify effects of key network statistics on infection transmission, and extent to which hsv-2 prevalence can be a proxy of hiv prevalence. | 2017 | 28514276 |
| migrating microbes: what pathogens can tell us about population movements and human evolution. | the biology of human migration can be observed from the co-evolutionary relationship with infectious diseases. while many pathogens are brief, unpleasant visitors to human bodies, others have the ability to become life-long human passengers. the story of a pathogen's genetic code may, therefore, provide insight into the history of its human host. the evolution and distribution of disease in africa is of particular interest, because of the deep history of human evolution in africa, the presence o ... | 2017 | 28511559 |
| surgical excision for recurrent herpes simplex virus 2 (hsv-2) anogenital infection in a patient with human immunodeficiency virus (hiv). | recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (hiv), of whom approximately 5% develop resistance to acyclovir. we present a case of a 49-year-old man with hiv who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. he initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. the lesion progressed to a large hypertrophic mass that required surgical exc ... | 2017 | 28508238 |
| a trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model. | an estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (hsv-2), the most common cause of genital ulcer disease. some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. a vaccine was developed that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (vzv), a closely related member of the herpesvirid ... | 2017 | 28481687 |
| associations between friendship characteristics and hiv and hsv-2 status amongst young south african women in hptn-068. | prevalence of hiv among young women in south africa remains extremely high. adolescent peer groups have been found to be an important influence on a range of health behaviours. the characteristics of young women's friendships might influence their sexual health and hiv risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. we investigated associations between young women's friendships and their herpes simplex virus type 2 (hsv-2) a ... | 2017 | 29285883 |
| dual-strain genital herpes simplex virus type 2 (hsv-2) infection in the us, peru, and 8 countries in sub-saharan africa: a nested cross-sectional viral genotyping study. | quantitative estimation of the extent to which the immune system's protective effect against one herpes simplex virus type 2 (hsv-2) infection protects against infection with additional hsv-2 strains is important for understanding the potential for hsv-2 vaccine development. using viral genotyping, we estimated the prevalence of hsv-2 dual-strain infection and identified risk factors. | 2017 | 29281620 |
| results of real-time multiplex polymerase chain reaction assay in renal transplant recipients with sterile pyuria. | urinary tract infections are a major cause of morbidity and hospitalization after renal transplantation. patients treated with immunosuppressive drugs suffer not only from common uropathogens but also from opportunistic infections caused by unusual uropathogens. sterile pyuria is associated with numerous infectious agents including viruses, fungi, and atypical or fastidious organisms. the objective of this study was to investigate the pathogens using real-time multiplex polymerase chain reaction ... | 2017 | 28735999 |
| a randomized safety and pharmacokinetic trial of daily tenofovir 1% gel in term and near-term pregnancy. | vaginal tenofovir (tfv) 1% gel may reduce incident hiv-1 and herpes simplex virus 2 infection. pregnancy may increase risk of hiv acquisition, and incident hiv in pregnancy potentiates perinatal hiv transmission. our objective was to investigate the safety and pharmacokinetics of seven days of tfv 1% vaginal gel in term and near-term pregnancy. | 2017 | 27658440 |
| herpes simplex virus 1 and 2 educational assessment of young adults in rural southwest virginia. | herpes simplex virus 2 (hsv-2) causes genital herpes, one of the most common sexually transmitted infections (stis) in the u.s. hsv-1, commonly associated with cold sores, is increasing as a cause of genital herpes. abstinence-only sexual health classes, commonly taught in virginia, generate young adults who are under-educated in sexual health, increasing sti risks. college students in southwest virginia were surveyed to assess comprehensiveness of high school health education regarding hsv-1 an ... | 2017 | 28654651 |
| latent virus reactivation in astronauts on the international space station. | reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight onboard the international space station . twenty age-matched and sex-matched healthy ground-based subjects were included as a control group. blood, urine, and saliva samples were collected before, during, and after spaceflight. saliva was analyzed for epstein-barr virus, varicella-zoster virus, and herpes simplex virus type 1. urine was a ... | 2017 | 28649633 |
| [evaluation of viral etiology in central nervous system infections from a university hospital point of view in izmir based on seven years data]. | the serious diseases of the central nervous system (cns); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. nucleic acid testing (nat) is the tool of choice for viral diagnosis in cns infections. in this study, viral etiological agents found in cerebrospinal fluid (csf) samples sent to our university hospital virology laboratory for laboratory diagnosis of cns infections were retrospectively evaluated and results were compared with ... | 2017 | 28566076 |
| herpes simplex virus type 2 acute retinal necrosis in an immunocompetent patient. | to report a case of acute retinal necrosis caused by herpes simplex virus 2 in an otherwise healthy patient. | 2017 | 28252688 |
| prevalence of herpes simplex virus type 2 and risk factors associated with this infection in women in southern brazil. | the herpes simplex virus type 2 (hvs-2) is the most prevalent infection worldwide. it is a cofactor in the acquisition of human immunodeficiency virus (hiv) and the persistence of human papillomavirus (hpv). this study evaluated the prevalence of hsv-2, using the polymerase chain reaction (pcr), and associated factors in patients treated at the federal university of rio grande (furg) and basic health units (bhu) in rio grande, brazil. the observed prevalence of hsv-2 was 15.6%. among the 302 wom ... | 2017 | 24037285 |
| us6 gene deletion in herpes simplex virus type 2 enhances dendritic cell function and t cell activation. | herpes simplex virus (hsv) type 1 (hsv-1) and type 2 (hsv-2) produce lifelong infections that are associated with frequent asymptomatic or clinically apparent reactivation. importantly, hsv express multiple virulence factors that negatively modulate innate and adaptive immune components. notably, hsv interfere with dendritic cell (dc) viability and function, likely hindering the capacity of the host to mount effective immunity against these viruses. recently, an hsv-2 virus that was deleted in g ... | 2017 | 29176979 |
| invasive obstetric procedures and cesarean sections in women with known herpes simplex virus status during pregnancy. | neonatal herpes is a potentially devastating infection that results from acquisition of herpes simplex virus (hsv) type 1 or 2 from the maternal genital tract at the time of vaginal delivery. current guidelines recommend (1) cesarean delivery if maternal genital hsv lesions are present at the time of labor and (2) antiviral suppressive therapy for women with known genital herpes to decrease hsv shedding from the genital tract at the time of vaginal delivery. however, most neonatal infections occ ... | 2017 | 29308404 |
| education, early screening and treatment of stis could reduce infertility among women in kenya. | in kenya, sexually transmitted infections (stis) such as chlamydia trachomatis, neisseria gonorrhoea, hiv, herpes simplex virus type 2 (hsv-2), syphilis and trichomoniasis tend to be prevalent, especially in women. further, the research shows that women who test positive for stis (other than hiv), have little knowledge of these infections. of particular concern, is that there has been little attention on the part of government to educate the general public about stis, yet these diseases can have ... | 2017 | 29209488 |
| hiv and herpes simplex virus type 2 epidemiological synergy: misguided observational evidence? a modelling study. | to investigate whether observational studies of hiv and herpes simplex virus type 2 (hsv-2) infections have the capacity to assess the hiv/hsv-2 epidemiological synergy. | 2017 | 29203577 |
| atypical presentation of herpes simplex virus type 2 infection refractory to treatment with acyclovir in 2 hematologic patients. | herpesvirus infections are not uncommon in hematologic patients. our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with acyclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. the second patient, diagnosed with follicular hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with acyclovir but that responded to intralesional cidofovir ... | 2017 | 29203034 |
| association between virus exposure and depression in us adults. | mood disorders are common mental illnesses. among the factors associated with major depression are exposures to infectious diseases including hepatitis c, influenza, varicella-zoster, and herpes viruses. in this study, we sought to evaluate further associations between viral exposure and depression. from the us center for disease control's national health and nutrition examination survey, we obtained data about depression status, antidepressant use, exposure to hepatitis a, hepatitis b, herpes s ... | 2017 | 29287239 |
| association between infection burden and adult height. | although highly heritable, adult height is also associated with numerous environmental factors, including exposure to infection. particularly in developing regions of the world, infection burden appears to slow growth during childhood. using a large database representative of the us population, we examined associations between adult height and leg length and an infection-burden index based on past exposure to toxocara species, toxoplasmosis gondii, cytomegalovirus, hepatitis a, hepatitis b, hepa ... | 2017 | 28926748 |
| performance of commercial enzyme-linked immunoassays for diagnosis of herpes simplex virus-1 and herpes simplex virus-2 infection in a clinical setting. | us food and drug administration-approved enzyme-linked immunoassays (eia) for determining type-specific herpes simplex virus (hsv) serostatus are widely used in clinical practice. we compared the performance of such assays with the university of washington western blot (uw wb) in patients who sought confirmation of their hsv serology result. | 2017 | 28876290 |
| real time pcr to evaluate hsv-2 shedding from anal and genital samples among men who have sex with men, living with hiv. | this study shows the relative quantification of hsv-2 by qpcr, using the miqe guidelines. the reaction efficiency was evaluated, and the relative quantification used the r = 2-δcq method. the relative quantification of hsv-2 was conducted with anal and genital samples from men who have sex with men (msm), living with hiv. the presence of a single amplification product was validated with a dissociation curves profile and the determination of the melting temperature. the limit of detection for β-g ... | 2017 | 29236293 |
| modeling hiv disease progression and transmission at population-level: the potential impact of modifying disease progression in hiv treatment programs. | mathematical models that incorporate hiv disease progression dynamics can estimate the potential impact of strategies that delay hiv disease progression and reduce infectiousness for persons not on antiretroviral therapy (art). suppressive treatment of hiv-positive persons co-infected with herpes simplex virus-2 (hsv-2) with valacyclovir, an hsv-2 antiviral, can lower hiv viral load, but the impact of partially-suppressive valacyclovir relative to fully-suppressive art on population hiv transmis ... | 2017 | 29223580 |
| anti hsv-2 activity of peganum harmala (l.) and isolation of the active compound. | genital herpes is a sexually transmitted disease caused by herpes simplex virus type 2 (hsv-2). nucleoside analogues such as acyclovir (acv) are the usual therapy for treating hsv infection. however, the overuse of this drug has led to the emergence of resistant strains. therefore, the search for new alternative or complementary molecules to overcome this obstacle is needed. in this objective, peganum harmala was investigated for its hsv-2 activity. the organic extracts of the different plant or ... | 2017 | 29223449 |
| prospective cohort study showing persistent hsv-2 shedding in women with genital herpes 2 years after acquisition. | herpes simplex virus type 2 (hsv-2) is a prevalent infection with great variability in clinical and virological manifestations among individuals. this prospective cohort study aims to evaluate the natural history of hsv-2 reactivation in the genital area in the same group of women over time. | 2017 | 29175899 |
| [herpes simplex virus infection: an overview of the problem, pharmacologic therapy and dietary measures]. | treatment of infectious diseases remains one of the principal research target for many researchers and healthcare providers worldwide. herpes simplex virus 1 (hsv-1) and herpes simplex virus 2 (hsv-2) are common human pathogens with an estimated 60-95% of the adult population infected by at least one of them. the worldwide disease burden of hsv is substantial, and acyclovir and related nucleoside analogues (viral dna polymerase inhibitors) as therapies have led to significantly increased treatme ... | 2017 | 28914066 |
| pharmacological induction of heme oxygenase-1 impairs nuclear accumulation of herpes simplex virus capsids upon infection. | heme oxygenase-1 (ho-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ros), as well as cytokines, among others. its activity can be positively modulated by cobalt protoporphyrin (copp) and negatively by tin protoporphirin (snpp). once induced, ho-1 degrades iron-containing heme into ferrous iron (fe2+), carbon monoxide (co) and biliverdin. importantly, numerous products of ho- ... | 2017 | 29163402 |
| hiv prevalence and associated risk factors among men who have sex with men in dar es salaam, tanzania. | limited studies and differential risk behaviours among men who have sex with men(msm) in africa calls for population specific studies. we present results from the largest integrated bio-behavioural survey among msm in africa to inform programming. | 2017 | 29140871 |
| seropositivity to herpes simplex virus type 2, but not type 1 is associated with cervical cancer: nhanes (1999-2014). | herpes simplex virus types 1 and 2 (hsv1 and hsv2) are infectious agents, and their association with cancer occurrence in human is a controversial topic for decades. we addressed this subject using all available continuous national health and nutrition examination survey (nhanes) cross-sectional data from 1999 to 2014. | 2017 | 29115946 |
| carbosilane dendrons with fatty acids at the core as a new potential microbicide against hsv-2/hiv-1 co-infection. | herpes simplex virus type 2 (hsv-2) and human immunodeficiency virus type 1 (hiv-1) represent the two most frequent sexually transmitted infections (sti) worldwide. epidemiological studies suggest that hsv-2 increases the risk of hiv-1 acquisition approximately 3-fold mainly due to the clinical and immunological manifestations. in the absence of vaccines against both sti, the development of new preventive strategies has become essential for further studies. we performed the screening of six nove ... | 2017 | 29090302 |
| novel role for interleukin-17 in enhancing type 1 helper t cell immunity in the female genital tract following mucosal herpes simplex virus 2 vaccination. | it is well established that interferon gamma (ifn-γ) production by cd4+ t cells is critical for antiviral immunity against herpes simplex virus 2 (hsv-2) genital infection. however, the role of interleukin-17a (il-17a) production by cd4+ t cells in hsv-2 antiviral immunity is yet to be elucidated. here we demonstrate that il-17a plays an important role in enhancing antiviral t helper type 1 (th1) responses in the female genital tract (fgt) and is essential for effective protection conferred by h ... | 2017 | 28956763 |
| [co-infections of hiv, syphilis and hsv-2 among men who have sex with men at the voluntary hiv counseling and testing clinics in shanghai]. | objective: to understand the prevalence rates of hiv-syphilis and hiv-herpes simplex virus 2 (hsv-2) co-infections and related factors among men having sex with men (msm) who had visited the voluntary hiv counseling and testing (vct) clinics in shanghai, china. methods: 756 eligible msm who attended the vct clinics of shanghai municipality and putuo district during march to august, 2015 were recruited to participate in a cross-sectional survey with questionnaire interview and blood testing for h ... | 2017 | 29060980 |
| antiviral effects of lactobacillus crispatus against hsv-2 in mammalian cell lines. | herpes simplex virus type 2 (hsv-2) infectious disease is one of the most common viral sexually transmitted diseases. as regards, vaginal lactobacilli play an important role in protecting host against the urogenital pathogens; here we assessed the potential antiviral activity of lactobacillus crispatus against hsv-2 infection in vitro. | 2017 | 29037754 |
| optimized enzyme-linked immunosorbent assay for detecting cytomegalovirus infections during clinical trials of recombinant vaccines. | in clinical trials of cytomegalovirus (cmv) glycoprotein b (gb) vaccines, cmv infection is detected by first depleting serum of anti-gb antibodies and then measuring anti-cmv antibodies with a commercially available enzyme-linked immunosorbent assay (elisa) kit, with confirmation of positive findings by immunoblot. | 2017 | 29035763 |
| the effect of school attendance and school dropout on incident hiv and hsv-2 among young women in rural south africa enrolled in hptn 068. | to estimate the association between school attendance, school dropout, and risk of incident hiv and herpes simplex virus type 2 (hsv-2) infection among young women. | 2017 | 28692544 |
| association between male circumcision and women's biomedical health outcomes: a systematic review. | male circumcision reduces men's risk of acquiring hiv and some sexually transmitted infections from heterosexual exposure, and is essential for hiv prevention in sub-saharan africa. studies have also investigated associations between male circumcision and risk of acquisition of hiv and sexually transmitted infections in women. we aimed to review all evidence on associations between male circumcision and women's health outcomes to benefit women's health programmes. | 2017 | 29025633 |
| strong associations between national prevalence of various stis suggests sexual network connectivity is a common underpinning risk factor. | if national peak human immunodeficiency virus (hiv) prevalence is positively associated with the prevalence of other sexually transmitted infections (stis) from before or early on in the hiv epidemics this would suggest common underlying drivers. | 2017 | 29025419 |
| network analysis of the hominin origin of herpes simplex virus 2 from fossil data. | herpes simplex virus 2 (hsv2) is a human herpesvirus found worldwide that causes genital lesions and more rarely causes encephalitis. this pathogen is most common in africa, and particularly in central and east africa, an area of particular significance for the evolution of modern humans. unlike hsv1, hsv2 has not simply co-speciated with humans from their last common ancestor with primates. hsv2 jumped the species barrier between 1.4 and 3 mya, most likely through intermediate but unknown homin ... | 2017 | 28979799 |
| differences in health-related quality of life between hiv-positive and hiv-negative people in zambia and south africa: a cross-sectional baseline survey of the hptn 071 (popart) trial. | the life expectancy of hiv-positive individuals receiving antiretroviral therapy (art) is approaching that of hiv-negative people. however, little is known about how these populations compare in terms of health-related quality of life (hrqol). we aimed to compare hrqol between hiv-positive and hiv-negative people in zambia and south africa. | 2017 | 28964756 |
| biologic interactions between hsv-2 and hiv-1 and possible implications for hsv vaccine development. | development of a safe and effective vaccine against herpes simplex virus type 2 (hsv-2) has the potential to limit the global burden of hsv-2 infection and disease, including genital ulcer disease and neonatal herpes, and is a global sexual and reproductive health priority. another important potential benefit of an hsv-2 vaccine would be to decrease hiv infections, as hsv-2 increases the risk of hiv-1 acquisition several-fold. acute and chronic hsv-2 infection creates ulcerations and draws dendr ... | 2017 | 28958807 |
| prevalent herpes simplex virus-2 increases the risk of incident bacterial vaginosis in women from south africa. | studies have shown that women diagnosed with herpes simplex virus-2 (hsv-2) have a higher risk for bacterial vaginosis (bv) infection. we investigated the presence of hsv-2 infections as a risk factor for incident bv infections in high risk, human immunodeficiency virus (hiv) uninfected women enrolled in a hiv prevention trial in durban, south africa. the vaginal and oral interventions to control the epidemic trial was a multicentre, double blinded, randomized controlled trial which was designed ... | 2017 | 28956191 |
| hiv prevalence and correlated factors of female sex workers and male clients in a border region of yunnan province, china. | female sex workers (fsws) and their male clients are vulnerable to hiv infection and serve as a bridge in hiv transmission from the high-risk population to the general, low-risk population. to examine the factors of fsws and male clients that correlate with the prevalence of hiv infection in the chinese-vietnamese border region, a cross-sectional survey was conducted in 2014 in the hekou county of the yunnan province of china. we performed a questionnaire survey to collect data on demographics, ... | 2017 | 28901213 |
| generation of “lymph node derived antibody libraries” (lyndal) for selecting fully human antibody fragments with therapeutic potential. | the development of efficient strategies for generating fully human monoclonal antibodies with unique functional properties that are exploitable for tailored therapeutic interventions remains a major challenge in the antibody technology field. here, we present a methodology for recovering such antibodies from antigen-encountered human b cell repertoires. as the source for variable antibody genes, we cloned immunoglobulin g (igg)-derived b cell repertoires from lymph nodes of 20 individuals underg ... | 2017 | 24256717 |
| human herpesviruses as copathogens of hiv infection, their role in hiv transmission, and disease progression. | of eight human herpesviruses (hhvs), often, only herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) find mention in medical literature as both of these viruses are commonly associated with genital lesions and oral ulcers, commonly known as cold sores. however, role of human herpesviruses as copathogens and in aggravation and in the transmission of other human diseases, especially the acquired immunodeficiency syndrome (hiv/aids) has only very recently been recognized. therefore, screening and tr ... | 2017 | 27013807 |
| association between herpes simplex virus types 1 and 2 with cardiac myxoma. | most cases of atrial myxoma are sporadic, and the exact etiology is unknown. we examined if herpes simplex virus (hsv)-1 and hsv-2 antigens and/or dna could be detected in a cohort of iranian patients with cardiac myxomas. from july 2004 to june 2014, among a total of 36,703 patients undergoing open heart surgeries, consecutive patients with cardiac myxoma who were treated by surgical excision at our center included in this study. of 73 patients studied, 56% were female with a mean age of 54 yea ... | 2017 | 28081512 |
| clinical characteristics of herpes simplex virus urethritis compared with chlamydial urethritis among men. | the aim of this study was to ascertain the clinical characteristics associated with herpes simplex virus (hsv) urethritis in men and to compare those with chlamydial urethritis. | 2017 | 28079748 |
| linear multiepitope (glyco)peptides for type-specific serology of herpes simplex virus (hsv) infections. | detection of type-specific antibodies is an important and essential part of accurate diagnosis, even in silent carriers of herpes simplex virus (hsv)-1 (oral) and hsv-2 (genital) infections. serologic assays that identify hsv-1 and hsv-2 type-specific antibodies have been commercially available for more than a decade but often face problems related to cross-reactivity and similar issues. attempts to identify type-specific peptide epitopes for use in serology for both hsv-1 and hsv-2 have been li ... | 2017 | 28238255 |
| the product of the herpes simplex virus type 2 ul16 gene is critical for the egress of capsids from the nuclei of infected cells. | the herpes simplex virus (hsv) ul16 gene is conserved throughout the herpesviridae and encodes a poorly understood tegument protein. the hsv-1 ul16 protein forms complexes with several viral proteins including ul11, ge, vp22 and ul21. we previously demonstrated that hsv-2 ul21 was essential for virus propagation due to the failure of dna-containing capsids to exit the nucleus. we hypothesized that if a ul16/ul21 complex were required for nuclear egress then hsv-2 lacking ul16 would have a simila ... | 2017 | 28275195 |
| first estimates of the global and regional incidence of neonatal herpes infection. | neonatal herpes is a rare but potentially devastating condition with an estimated 60% fatality rate without treatment. transmission usually occurs during delivery from mothers with herpes simplex virus type 1 (hsv-1) or type 2 (hsv-2) genital infection. however, the global burden has never been quantified to our knowledge. we developed a novel methodology for burden estimation and present first who global and regional estimates of the annual number of neonatal herpes cases during 2010-15. | 2017 | 28153513 |
| bx-795 inhibits hsv-1 and hsv-2 replication by blocking the jnk/p38 pathways without interfering with pdk1 activity in host cells. | bx-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (pdk1), but also a potent inhibitor of the ikk-related kinase, tankbinding kinase 1 (tbk1) and ikkɛ. in this study we attempted to elucidate the molecular mechanism(s) underlying the inhibition of bx-795 on herpes simplex virus (hsv) replication. hec-1-a or vero cells were treated with bx-795 and infected with hsv-1 or hsv-2 for different periods. bx-795 (3.125-25 μmol/l) dose-dependently suppressed hsv-2 replication, and displayed ... | 2017 | 28112176 |
| automated processing, extraction and detection of herpes simplex virus types 1 and 2: a comparative evaluation of three commercial platforms using clinical specimens. | recently, automated platforms have been developed that can perform processing, extraction and testing for herpes simplex virus (hsv) nucleic acid on a single instrument. | 2017 | 28226272 |
| comparison of commercial methods of immunoblot, elisa, and chemiluminescent immunoassay for detecting type-specific herpes simplex viruses-1 and -2 igg. | serology for type-specific herpes simplex virus (hsv) is based on the use of the respective glycoprotein g (gg). | 2017 | 28332725 |
| bizarre cell dysplasia of the cervix. | the aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (hsil) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (bcd). | 2017 | 28150409 |
| peptides derived from glycoproteins h and b of herpes simplex virus type 1 and herpes simplex virus type 2 are capable of blocking herpetic infection in vitro. | the aim of this study was to design peptides derived from glycoproteins h (gh) and b (gb) of herpes simplex viruses type 1 (hsv-1) and type 2 (hsv-2) with the potential to block herpetic infection and to evaluate their ability to inhibit hsv-1 and hsv-2 infection in vitro. | 2017 | 28329739 |
| worldwide circulation of hsv-2 × hsv-1 recombinant strains. | homo sapiens harbor two distinct, medically significant species of simplexviruses, herpes simplex virus (hsv)-1 and hsv-2, with estimated divergence 6-8 million years ago (mya). unexpectedly, we found that circulating hsv-2 strains can contain hsv-1 dna segments in three distinct genes. using over 150 genital swabs from north and south america and africa, we detected recombinants worldwide. common, widely distributed gene ul39 genotypes are parsimoniously explained by an initial >457 basepair (b ... | 2017 | 28287142 |
| ancient recombination events between human herpes simplex viruses. | herpes simplex viruses 1 and 2 (hsv-1 and hsv-2) are seen as close relatives but also unambiguously considered as evolutionary independent units. here, we sequenced the genomes of 18 hsv-2 isolates characterized by divergent ul30 gene sequences to further elucidate the evolutionary history of this virus. surprisingly, genome-wide recombination analyses showed that all hsv-2 genomes sequenced to date contain hsv-1 fragments. using phylogenomic analyses, we could also show that two main hsv-2 line ... | 2017 | 28369565 |
| antiviral activity of pha767491 against human herpes simplex virus in vitro and in vivo. | herpes simplex virus (hsv) is a common human pathogen that causes a variety of diseases, including oral-labial, genital lesions and life-threatening encephalitis. the antiviral nucleoside analogues such as acyclovir are currently used in anti-hsv therapies; however, clinical overuse of these drugs has led to the emergence of drug-resistant viral strains. hence, there is an urgent need to develop new anti-hsv agents. | 2017 | 28320320 |
| occurrence of viral dna in paired samples of corneal rim and cornea preservation fluid. | corneal transplants have one of the highest success rates among all transplantological procedures. corneas intended for transplantation are stored in a preservation fluid, which is then tested for bacterial and fungal infections. among all analyses of infectious complications following corneal transplants, infections caused by bacteria or fungi are the most prominent. surprisingly, however, apart from a few publications, there is a lack of data regarding the occurrence of viruses in donor cornea ... | 2017 | 27588373 |
| prevalence of herpesviruses in gingivitis and chronic periodontitis: relationship to clinical parameters and effect of treatment. | assess the prevalence of herpesviruses in healthy subjects, gingivitis, and chronic periodontitis patients, to assess the relationship between the prevalence of herpesviruses and periodontal clinical parameters, and to evaluate the effect of phase-i therapy on the level of viral detection. | 2017 | 27563201 |
| neurotrophic factors ngf, gdnf and ntn selectively modulate hsv1 and hsv2 lytic infection and reactivation in primary adult sensory and autonomic neurons. | herpes simplex viruses (hsv1 and hsv2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. previous studies showed that nerve growth factor (ngf) maintains hsv1 latency in embryonic sympathetic and sensory neurons. however, adult sensory neurons are no longer dependent on ngf for survival, some populations cease expression of ngf receptors postnatally, and the viruses preferentially esta ... | 2017 | 28178213 |
| atypical herpetic whitlow: a diagnosis to consider. | herpetic whitlow is caused by herpes virus (type1 or 2) during primary infection or as result of autoinoculation. commonly, it is caused by hsv-2 in adults with positive history for genital infection. we report a rare case of herpetic whitlow that should be kept in mind by physicians in recurrent cases of fingers infection. advanced diagnostic techniques as pcr are required to help clinicians to achieve a definite diagnosis and to choose the right treatment. | 2017 | 28376707 |
| leflunomide in the treatment of a pseudotumoral genital herpes simplex virus infection in an hiv patient. | the patient is a 52-year-old african american man with a past medical history of hiv infection (on antiretroviral therapy, cd4 count 399 cells/µl, and undetectable hiv viral load) and recurrent genital herpes. while on valacyclovir, the patient presented with four tumorous lesions on the perineum and scrotum. a biopsy specimen stained positively with hsv-1 and hsv-2 immunostains and displayed a lymphoplasmacytic infiltrate. the patient received foscarnet and imiquimod for two weeks with minimal ... | 2017 | 28373917 |
| acute hiv-1 infection presenting with fulminant encephalopathy. | human immunodeficiency virus (hiv)-1 directly affects the nervous system, causes distinct neurological symptoms, and indirectly results in opportunistic infections, which include herpes virus simplex (hsv)-1, hsv-2, varicella zoster virus, and cytomegalovirus encephalitis caused by immunodeficiency. early hiv-1 invasion of the central nervous system is also possible, and acute encephalopathy is a potentially lethal complication. we encountered a case of fulminant encephalopathy as a primary pres ... | 2017 | 28201953 |
| role of type-specific herpes simplex virus-1 and 2 serology as a diagnostic modality in patients with clinically suspected genital herpes: a comparative study in indian population from a tertiary care hospital. | type-specific serology (tss) test for herpes simplex virus (hsv) have been used as a research tool in seroepidemiological studies for some years. however, tss as a diagnostic modality for diagnosis of current episode of genital herpes is not well documented. | 2017 | 27510668 |
| absent anti-n-methyl-d-aspartate receptor nr1a antibodies in herpes simplex virus encephalitis and varicella zoster virus infections. | a 2012 report and subsequent case series described anti-n-methyl-d-aspartate receptor (nmdar) antibodies in patients during the acute phase and relapse of herpes simplex virus 1 (hsv1) encephalitis (hsv1e). however, the prevalence of this phenomenon is unknown and systematic studies on other viral infections of the nervous system are missing. | 2017 | 26887329 |
| prevalence of neurotropic viruses in malignant glioma and their onco-modulatory potential. | the association between infectious agents and tumour aetiology is relevant in about 20% of cases. | 2017 | 28358704 |
| hiv and sti s among men who have sex with men in dodoma municipality, tanzania: a cross-sectional study. | to determine the seroprevalence of hiv, sti and related risks among men who have sex with men (msm) in dodoma municipality, tanzania. | 2017 | 28202736 |
| effect of mycoplasma hominis and cytomegalovirus infection on pregnancy outcome: a prospective study of 200 mongolian women and their newborns. | in mongolia, diagnostic tests for the detection of the sexually transmitted mycoplasmas, ureaplasmas, herpes simplex virus (hsv), and cytomegalovirus (cmv) are currently not routinely used in clinical settings and the frequency of these stis are enigmatic. the prevalence of these sti pathogens were prospectively evaluated among 200 mongolian pregnant women and their newborns and correlated with pregnancy outcome. taqman pcrs were used to detect bacterial and viral sti pathogens in pre-birth vagi ... | 2017 | 28257513 |
| the infectious etiology of alzheimer's disease. | inflammation is a part of the first line of defense of the body against invasive pathogens, and plays a crucial role in tissue regeneration and repair. a proper inflammatory response ensures the suitable resolution of inflammation and elimination of harmful stimuli, but when the inflammatory reactions are inappropriate it can lead to damage of the surrounding normal cells. the relationship between infections and alzheimer's disease (ad) etiology, especially late-onset ad (load) has been continuo ... | 2017 | 28294067 |
| maternal immunoreactivity to herpes simplex virus 2 and risk of autism spectrum disorder in male offspring. | maternal infections during pregnancy are associated with risk of neurodevelopmental disorders, including autism spectrum disorders (asds). proposed pathogenetic mechanisms include fetal infection, placental inflammation, and maternal cytokines or antibodies that cross the placenta. the autism birth cohort comprises mothers, fathers, and offspring recruited in norway in 1999 to 2008. through questionnaire screening, referrals, and linkages to a national patient registry, 442 mothers of children w ... | 2017 | 28251181 |
| infection and inflammation in schizophrenia and bipolar disorder. | the present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (sz), bipolar disorder (bp), and controls without a psychiatric disorder. we measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. in both sz and bp, we found an increase in soluble cd14, and in bp an increase in c-reactive protein, igm class antibodies against cytomegalovirus ( ... | 2017 | 27856235 |
| sexually transmitted infection risk among women is not fully explained by partner numbers. | increased sexual partner numbers may contribute to sexually transmitted infection (sti) risk for some but not all women. this study compared women reporting having four or more partners during the preceding year (multiple partnership group) with those reporting having one partner (single partnership group) with regard to sexually risky behaviors and other modifiable predictors of sti risk. we also compared the prevalence of bacterial vaginosis, trichomoniasis, chlamydia, gonorrhea, syphilis, her ... | 2017 | 28257539 |
| costing of national sti program implementation for the global sti control strategy for the health sector, 2016-2021. | in 2016 the world health assembly adopted the global strategy on sexually transmitted infections (sti) 2016-2021 aiming to reduce curable stis by 90% by 2030. we costed scaling-up priority interventions to coverage targets. | 2017 | 28129372 |
| establishment of multiplex solid-phase strip pcr test for detection of 24 ocular infectious disease pathogens. | to establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip pcr) for concurrent detection of common ocular infectious disease pathogens. | 2017 | 28282487 |
| diclofenac-based hydrazones and spirothiazolidinones: synthesis, characterization, and antimicrobial properties. | we report here the synthesis, structural characterization, and biological evaluation of novel diclofenac-based hydrazone (4a-f) and spirothiazolidinone (5a-f, 6a-f) derivatives designed as potential antimicrobial agents. the compounds were evaluated in vitro for their antiviral activity against a wide spectrum of dna and rna viruses. they were further screened in vitro against different strains of bacteria and fungi. the hydrazone derivatives, 4a and 4c-f, were found to be active against herpesv ... | 2017 | 28370198 |
| future prospects for new vaccines against sexually transmitted infections. | this review provides an update on the need, development status, and important next steps for advancing development of vaccines against sexually transmitted infections (stis), including herpes simplex virus (hsv), neisseria gonorrhoeae (gonorrhea), chlamydia trachomatis (chlamydia), and treponema pallidum (syphilis). | 2017 | 27922851 |
| investigation on the association between thyroid tumorigeneses and herpesviruses. | herpesviruses have been associated with various human malignancies and with thyroid autoimmunity. aiming to investigate the presence of these viruses in thyroid nodules, we analyzed serum and thyroid tissue from 183 patients (83 benign and 100 malignant thyroid nodules). we also obtained 104 normal thyroid tissues extracted from the contralateral lobe of these patients. we used elisa to screen the serology of all patients and a real-time quantitative pcr to analyze thyroid tissue viral load in a ... | 2017 | 28276007 |
| effects of cumulative herpesviridae and toxoplasma gondii infections on cognitive function in healthy, bipolar, and schizophrenia subjects. | schizophrenia and bipolar disorder are associated with cognitive impairment leading to social disruption. while previous studies have focused on the effect of individual infectious exposure, namely, herpesviridae viruses or toxoplasma gondii (t gondii), on cognitive functioning, the objective of the present study was to examine the effect of multiple infections on cognitive functioning in patients with schizophrenia and bipolar disorder and in healthy controls. | 2017 | 27929612 |
| temporal cognitive decline associated with exposure to infectious agents in a population-based, aging cohort. | numerous cross-sectional studies have related exposure to neurotropic infectious agents with cognitive dysfunction in older adults, however, the temporal sequence is uncertain. | 2017 | 26710257 |
| virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex pcr assay. | several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-hsct) are frequent, but viral reactivations after autologous hsct (auto-hsct) have not been investigated in detail. we performed multiplex polymerase chain reaction (pcr) assay to examine multiple viral reactivations simultaneously in 24 patients undergoing auto-hsct between september 2010 and december 2012. weekly whole blood samples were collected from pre- to 42 days post ... | 2017 | 27364410 |
| griffithsin carrageenan fast dissolving inserts prevent shiv hsv-2 and hpv infections in vivo. | human immunodeficiency virus (hiv) pre-exposure prophylaxis (prep) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. moreover, on-demand products are currently missing from the prep development portfolio. griffithsin (grft) is a non-antiretroviral hiv entry inhibitor derived from red algae with an excellent safety profile and potent activity in vitro. when combined ... | 2018 | 30250170 |
| vaccine-induced antibodies to herpes simplex virus glycoprotein d epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs. | herpes simplex virus type 2 (hsv-2) glycoprotein d (gd2) subunit antigen is included in many preclinical candidate vaccines. the rationale for including gd2 is to produce antibodies that block crucial gd2 epitopes involved in virus entry and cell-to-cell spread. hsv-2 gd2 was the only antigen in the herpevac trial for women that protected against hsv-1 genital infection but not hsv-2. in that trial, a correlation was detected between gd2 elisa titers and protection against hsv-1, supporting the ... | 2018 | 29791513 |
| heterogeneity of herpes simplex virus type 2 seroprevalence from a national probability survey in mexico, 2012. | herpes simplex virus type 2 (hsv-2) seroprevalence and associated infection risk factors show differences by regions and countries. the aims of the study were to determine the hsv-2 seroprevalence and to evaluate the risk factors for hsv-2 in a national representative survey among adolescents and adults in mexico. | 2018 | 28876288 |
| herpes simplex virus 2 latency-associated transcript (lat) region mutations do not identify a role for lat-associated micrornas in viral reactivation in guinea pig genital models. | despite the long-standing observation that herpes simplex virus (hsv) latency-associated transcript (lat) promoter deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. we constructed and evaluated four mutant hsv-2 isolates with targeted mutations in the lat promoter and lat-associated micrornas (mirnas) affecting (i) the lat tata box; (ii) the lat icp4-binding site; (iii) mirna i (mir-i) a ... | 2018 | 29720520 |
| co-infection of human herpesvirus type 2 (hhv-2) and human immunodeficiency virus (hiv) among pregnant women in rio de janeiro, brazil. | pregnant women who are infected with the human immunodeficiency virus (hiv) are particularly vulnerable to severe and recurrent infections with human herpesvirus 2 (hhv-2). neonatal transmission of hhv-2 has been associated with malformations and neurological sequelae in infants, which makes it very important to perform antenatal monitoring for genital herpes. in the study, 134 pregnant women infected with hiv were tested for hhv-2 igm and igg using an enzyme-linked immunosorbent assay (elisa) a ... | 2018 | 28914079 |
| transcriptional analysis of the guinea pig mucosal immune response to intravaginal infection with herpes simplex virus type 2. | genital herpes infection in guinea pigs closely models human infection but tools for immune characterization are limited. immunity to hsv infection at the vaginal epithelial surface was characterized in guinea pigs using pcr-based array analysis of vaginal swab samples. ifnγ was one of the most significantly upregulated genes throughout the infection and over 40% of genes with significantly altered expression were linked to ifnγ based on interferome analysis. ifnγ transcripts and biologically ac ... | 2018 | 29604476 |
| school support as structural hiv prevention for adolescent orphans in western kenya. | using a clustered randomized controlled trial design, we evaluated whether support to keep kenyan orphaned adolescents in school reduces the risk of hiv infection. | 2018 | 29107569 |
| expression and characterization of the soluble form of recombinant mature hsv-2 glycoprotein g for use in anti-hsv-2 igg serodiagnostic immunoassay. | herpes simplex virus type-2 (hsv-2) specific glycoprotein g (gg-2) is widely used as the antigen of choice for serodiagnosis of hsv-2. in order to develop an elisa for serodetection of hsv-2 igg in patient sera, the soluble form of the mature gg-2 antigen (mgg-2), gg283-649, was expressed using a baculovirus expression system. gg283-649 contains the complete extracellular domain of mgg-2 including the c-terminal region, which despite homology to gg-1, does not cross-react with hsv-1 antibodies p ... | 2018 | 29104048 |
| a concise synthesis of rhamnan oligosaccharides with alternating α-(1→2)/(1→3)-linkages and repeating α-(1→3)-linkages by iterative α-glycosylation using disaccharide building blocks. | a concise synthetic route to rhamnan oligosaccharides with alternating α-(1→2)/(1→3)-linkages and repeating α-(1→3)-linkages is reported. this synthesis was achieved by iterative α-glycosylation using disaccharide building blocks and through orthogonal coupling between thioglycosides of l-rhamnose. to investigate the detailed structure-activity relationship of rhamnan sulfate from monostroma nitidum against herpes simplex virus type 2, the synthesized oligosaccharides, bearing different orthogon ... | 2018 | 29156420 |
| the ticking clock of hsv-2 pathology. | herpes simplex virus type 2 (hsv-2) is the causative agent of genital herpes. matsuzawa et al have demonstrated that, in a mouse model, hsv-2 pathology is influenced by the time infection occurs. increased expression of the hsv-2 receptor nectin-1 under the control of clock coincided with an increase in viral titer suggesting that hsv-2 infection is regulated by the host circadian clock. | 2018 | 29273146 |
| intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic hsv-2 strains. | herpes simplex virus 2 (hsv-2) is the leading cause of genital herpes and increases the risk of hiv infection, but there is no effective vaccine. a replication-defective hsv-2 mutant virus, dl5-29, is effective in animal models and has been in a phase i trial. previous studies have shown that dl5-29 gives higher antibody responses and better protection when inoculated intramuscularly (im) as compared with subcutaneously (sc). however, the basis for this effect has not been defined. we confirmed ... | 2018 | 29069622 |