Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| prevalence and determinants of hsv-2/syphilis co-infection and hsv-2 mono-infection among hiv-positive men who have sex with men: a cross-sectional study in northeast china. | we aimed to assess the prevalence and determinants of herpes simplex virus type 2 (hsv-2) mono-infection and hsv-2/syphilis co-infection in human immunodeficiency virus (hiv)-positive men who have sex with men (msm) in china. a cross-sectional study was conducted on 545 hiv-positive msm in shenyang between february 2009 and october 2014. participants received physical examinations and serological tests for hsv-2 and syphilis. a multinomial logistic regression was used to identify risk factors as ... | 2016 | 27795468 |
| rna-binding protein cpeb1 remodels host and viral rna landscapes. | host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (hcmv) infection results in widespread alternative splicing (as), shortening of 3' untranslated regions (3' utrs) and lengthening of poly(a)-tails in host gene transcripts. we found that the host rna-binding protein cpeb1 was highly induced after infection, and ectopic exp ... | 2016 | 27775709 |
| seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in arkhangelsk, northwest russia: a population-based cross-sectional study. | herpes simplex virus type 2 (hsv-2) infection is the most common cause of genital ulcer disease (gud) worldwide. mother to child transmission causes high morbidity and mortality among infants. russia is on the brink of a generalized hiv-epidemic, but arkhangelsk is still a low-prevalence area. hsv-2 infection is associated with a three-fold increased risk of hiv-infection. the evidence on the seroprevalence of hsv-2 in russia is limited. the aim of this study was to assess hsv-2 seroprevalence a ... | 2016 | 27793121 |
| association of depressed mood with herpes simplex virus-2 immunoglobulin-g levels in pregnancy. | depressed mood is common in pregnancy, is associated with stress, and could result in immune suppression that may lead to latent herpes viral reactivation. this study investigated whether depressed mood is associated with higher herpes viral igg levels in pregnant women. | 2016 | 27490851 |
| high rates of herpes simplex virus type 2 infection in homeless women: informing public health strategies. | homeless and unstably housed women living in an urban setting are at risk for sexually transmitted diseases, yet the seroprevalence and correlates of herpes simplex virus type 2 (hsv-2) specific to impoverished women are poorly understood. | 2016 | 27243474 |
| herpes simplex acute retinal necrosis presenting as unilateral disc swelling in young immunocompetent patients. | to report two cases of young immunocompetent males with herpes simplex acute retinal necrosis (hsv arn) with initial diagnosis of unilateral disc swelling. | 2016 | 27230575 |
| access of protective antiviral antibody to neuronal tissues requires cd4 t-cell help. | circulating antibodies can access most tissues to mediate surveillance and elimination of invading pathogens. immunoprivileged tissues such as the brain and the peripheral nervous system are shielded from plasma proteins by the blood-brain barrier and blood-nerve barrier, respectively. yet, circulating antibodies must somehow gain access to these tissues to mediate their antimicrobial functions. here we examine the mechanism by which antibodies gain access to neuronal tissues to control infectio ... | 2016 | 27225131 |
| anti-apoptotic function of herpes simplex virus -2 latency-associated transcript rl1 sequence and screening of its encoded micrornas. | the latency-associated transcript (lat) gene of herpes simplex virus (hsv)-2 is the only detectable viral gene expressed during latent infection in neurons. lat inhibits apoptosis and maintains latency by promoting the survival of infected neurons. however, whether lat functions during hsv-2 infection via its encoded rnas or via its encoded proteins remain unknown. increasing evidence has indicated that lat is likely to functionally promote the establishment of latent infection via lat-encoded m ... | 2016 | 27663158 |
| detection of herpes simplex virus type 2 (hsv-2) -specific cell-mediated immune responses in guinea pigs during latent hsv-2 genital infection. | genital infections with herpes simplex virus type 2 (hsv-2) are a source of considerable morbidity and are a health concern for newborns exposed to virus during vaginal delivery. additionally, hsv-2 infection diminishes the integrity of the vaginal epithelium resulting in increased susceptibility of individuals to infection with other sexually transmitted pathogens. understanding immune protection against hsv-2 primary infection and immune modulation of virus shedding events following reactivati ... | 2016 | 27659010 |
| [factors related to syphilis and other infections among female drug users in shandong women's compulsory drug rehabilitation center in 2015]. | objective: to analyze the prevalence of hiv, syphilis and related factors among female drug users in shandong women's compulsory drug rehabilitation center(swcdrc). methods: during may 2015, we used a cluster sampling method for drug users in swcdrc, with a questionnaire and serological testing. we included respondents who volunteered to take part in this study, had clear histories of drug abuse, and had no symptoms of psychosis or current drug use; 451 women participated. the questionnaire addr ... | 2016 | 27655604 |
| immune responses elicited by the gen-003 candidate hsv-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial. | gen-003 is a candidate therapeutic hsv-2 vaccine containing a fragment of infected cell protein 4 (icp4.2), a deletion mutant of glycoprotein d2 (gd2δtmr), and matrix-m2 adjuvant. in a dose-ranging phase 1/2a clinical trial, immunization with gen-003 reduced viral shedding and the percentage of reported herpetic lesion days. here we examine the immune responses in the same trial, to characterize vaccine-related changes in antibody and cell-mediated immunity. | 2016 | 27642130 |
| linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases. | the initial steps of viral infections are mediated by interactions between viral proteins and cellular receptors. blocking the latter with high-affinity ligands may inhibit infection. dc-sign, a c-type lectin receptor expressed by immature dendritic cells and macrophages, mediates human immunodeficiency virus (hiv) infection by recognizing mannose clusters on the hiv-1 gp120 envelope glycoprotein. mannosylated glycodendrimers act as hiv entry inhibitors thanks to their ability to block this rece ... | 2016 | 27641362 |
| marital age disparity among orphaned young women and their husbands: a mixed methods study in rural zimbabwe. | our study reports the results from a mixed method study comparing age-similar (as) marriages of orphaned young women to age disparate (ad) marriages, defined as spousal age difference of 5 or more years. research in zimbabwe and sub-saharan africa suggests that ad sexual relationships between older men and young women increase the risk for hiv but few studies have examined this association among married couples or explored why young women marry much older men. in this study, a total of 35 orphan ... | 2016 | 27614653 |
| effects of female sex hormones on susceptibility to hsv-2 in vaginal cells grown in air-liquid interface. | the lower female reproductive tract (frt) is comprised of the cervix and vagina, surfaces that are continuously exposed to a variety of commensal and pathogenic organisms. sexually transmitted viruses, such as herpes simplex virus type 2 (hsv-2), have to traverse the mucosal epithelial lining of the frt to establish infection. the majority of current culture systems that model the host-pathogen interactions in the mucosal epithelium have limitations in simulating physiological conditions as they ... | 2016 | 27589787 |
| ficus religiosa l. bark extracts inhibit infection by herpes simplex virus type 2 in vitro. | ficus religiosa extracts have been used in traditional indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. the aim of this study was to investigate the antiviral activity of f. religiosa extracts against herpes simplex virus type 2 (hsv-2), the main causative agent of genital ulcers and sores. water and chloroform bark extracts were the most active against hsv-2, and also against an acyclovir-resistant strain. we demonstrate that the water extract has a ... | 2016 | 27581805 |
| secreted herpes simplex virus-2 glycoprotein g alters thermal pain sensitivity by modifying ngf effects on trpv1. | genital herpes is a painful disease frequently caused by the neurotropic pathogen herpes simplex virus type 2 (hsv-2). we have recently shown that hsv-2-secreted glycoprotein g (sgg2) interacts with and modulates the activity of the neurotrophin nerve growth factor (ngf). this interaction modifies the response of the ngf receptor trka, increasing ngf-dependent axonal growth. ngf is not only an axonal growth modulator but also an important mediator of pain and inflammation regulating the amount, ... | 2016 | 27576911 |
| intravaginal practices and prevalence of sexual and reproductive tract infections among women in rural malawi. | many women engage in intravaginal practices (ivp) with a goal of improving genital hygiene and increasing sexual pleasure. intravaginal practices can disrupt the genital mucosa, and some studies have found that ivp increases risk of acquisition of hiv and bacterial vaginosis (bv). limited prior research also suggests significant associations between ivp, herpes simplex virus type 2 (hsv-2), and high-risk types of human papillomavirus (hpv). | 2016 | 27835627 |
| hiv positive patient with hsv-2 encephalitis: case report. | incidence of brain infections in human immunodeficiency virus (hiv) positive patients is reduced after the availability of current high active antiretroviral therapy (haart). herpes simplex virus type 2 (hsv-2) is an infrequent cause of encephalitis in hiv patients despite it is frequently involved in sexual transmitted infections. here, we report a case of hsv-2 encephalitis occurring in a patient without full suppression of hiv replication within the brain. a 38 year-old hiv infected man was a ... | 2016 | 27668908 |
| progesterone augments cell susceptibility to hiv-1 and hiv-1/hsv-2 co-infections. | in human immunodeficiency virus type 1 (hiv-1)-infected women, oral or injectable progesterone containing contraceptive pills may enhance hiv-1 acquisition in vivo, and the mechanism by which this occurs is not fully understood. in developing countries, herpes simplex virus type-2 (hsv-2) co-infection has been shown to be a risk for increase of hiv-1 acquisition and, if co-infected women use progesterone pills, infections may increase several fold. in this study, we used an in vitro cell culture ... | 2016 | 27538988 |
| could zinc oxide tetrapod nanoparticles be used as an effective immunotherapy against hsv-2? | 2016 | 27527812 | |
| fulminant hepatic and multiple organ failure following acute viral tonsillitis: a case report. | pyogenic tonsillitis may often be observed in the general western population. in severe cases, it may require antibiotic treatment or even hospitalization and often a prompt clinical response will be noted. here we present an unusual case of progressive multiple organ failure including fulminant liver failure following acute tonsillitis initially mistaken for "classic" pyogenic (that is bacterial) tonsillitis. | 2016 | 26785992 |
| prevalence and risk factors of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in papua new guinea: a cross-sectional survey. | background papua new guinea (png) is estimated to have among the highest prevalences of hiv and sexually transmissible infections (stis) of any asia-pacific country, and one of the highest burdens of maternal syphilis globally. the prevalence of curable stis, such as chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv), among pregnant women in png is relatively unknown. | 2016 | 28636866 |
| effects of a traditional chinese medicine, longdanxiegan formula granule, on toll-like receptor pathway in female guinea pigs with recurrent genital herpes. | the aim of the present study was to investigate the effects of longdanxiegan formula granule (ldxgfg), a chinese traditional medicine on toll-like receptor (tlr) pathway in recurrent genital herpes. | 2016 | 27125405 |
| herpes simplex type 2 encephalitis and methotrexate medication: a fortuitous or causative association in a patient with spondyloarthritis? | it is unclear whether immunosuppression is a risk factor for herpes encephalitis. herein, we describe a rare case of herpes simplex virus type 2 encephalitis in a patient treated with low-dose methotrexate for hla-b27-associated spondyloarthritis. the patient was successfully treated with acyclovir but presented sequelae of encephalitis. here we discuss the possible role of low-dose methotrexate therapy as a risk factor of neurological herpes reactivation and severe disease. the host-related and ... | 2016 | 27879484 |
| fulminant hepatic failure in a patient with crohn's disease on infliximab possibly related to reactivation of herpes simplex virus 2 infection. | hsv hepatitis is a rare but often fatal cause of liver failure which tends to affect immunocompromised individuals. early treatment with acyclovir has been shown to reduce mortality in hsv hepatitis making recognition of the condition critically important. here, we present a case of hsv hepatitis in a young woman with crohn's disease on prednisone, azathioprine, and infliximab. we discuss the clinical presentation of hsv hepatitis as well as the possible causes of hepatitis in a patient on these ... | 2016 | 27818806 |
| mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes. | pharmacokinetic and pharmacodynamic models estimate the potency of antiviral agents but do not capture viral and immunologic factors that drive the natural dynamics of infection. we designed a mathematical model that synthesizes pharmacokinetics, pharmacodynamics, and viral pathogenesis concepts to simulate the activity of pritelivir, a dna helicase-primase inhibitor that targets herpes simplex virus. our simulations recapitulate detailed viral kinetic shedding features in five dosage arms of a ... | 2016 | 26843190 |
| comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein d receptors, herpes virus entry mediator a, nectin-1 and nectin-2, in transgenic mice. | herpesvirus entry mediator a (hvem), nectin-1 and nectin-2 are cellular receptors of glycoprotein d (gd) of herpes simplex virus type-2 (hsv-2). it has been shown that soluble forms of hsv gd receptors have the antiviral potential in cultured cells and transgenic mice. here, to compare antiviral potential of soluble forms of hvem, nectin-1 and nectin-2 against hsv-2 infections in vivo, transgenic mice expressing fusion proteins consisting of the entire ectodomain of hvem, nectin-1 or nectin-2 an ... | 2017 | 28671524 |
| optimized dna vaccine enhanced by adjuvant il28b induces protective immune responses against herpes simplex virus type 2 in mice. | antigen-specific immune responses determine the efficacy of herpes simplex virus type 2 (hsv-2) vaccines. to optimize the immunogenicity of the antigen gd2, we developed the gd2δul25 dna vaccine encoding hsv-2 glycoprotein d and ul25 gene encoding viral capsid vertex proteins in this study. the gd2 and gd2δul25 dna vaccines were compared with formalin-inactivated hsv-2 (fi-hsv-2), and results showed a greater protective immune response induced by gd2δul25 than by gd2. therefore, gd2δul25 was cho ... | 2017 | 28650722 |
| chronic herpetic retinitis: clinical features and long-term outcomes. | chronic uveitis treated with immunosuppressive agents may have unfavorable outcomes due to delays in diagnosis. the aim of this study was to review initial data from clinical and ocular assessments and patient outcomes following specific treatments for atypical herpes virus ocular infections. | 2017 | 28628343 |
| herpes simplex virus-2 transmission following solid organ transplantation: donor-derived infection and transplantation from prior organ recipients. | owing to limited availability of donor organs, previous solid organ transplant (sot) recipients are increasingly considered as potential organ donors. we report donor-derived transmission of herpes simplex virus type-2 (hsv-2) to two clusters of sot recipients with transmission from the original donor and an hsv-2-infected recipient who subsequently became a donor. | 2017 | 28618165 |
| analysis of cervical lesions for presence of hsv-2 and hpv-16 and hpv-18 in iranian patients by pcr. | objective cervical cancer (cc) is one of the leading causes of deaths from cancer among women worldwide. viral infections is now one of the known risk factors for cc. the aim of this study was to investigate the presence of herpes simplex virus type 2 (hsv-2), human papilloma virus types 16 (hpv-16) and human papilloma virus types 18 (hpv-18) in iranian patients with cc using the polymerase chain reaction (pcr). materials and methods this case-control study was conducted on a total of 45 patient ... | 2017 | 28609291 |
| does maternal hsv-2 coinfection increase mother-to-child transmission of hiv? a systematic review. | reducing hiv mother-to-child transmission (mtct) is critical to ending the hiv pandemic. reports suggest that herpes simplex virus-2 (hsv-2), a common coinfection in hiv-infected individuals, is associated with increased mtct, but results have been conflicting. we conducted a systematic review of observational studies to quantify the magnitude of this relationship (prospero no. crd42016043315). | 2017 | 28600331 |
| prevalence, incidence and correlates of hsv-2 infection in an hiv incidence adolescent and adult cohort study in western kenya. | herpes simplex virus type 2 (hsv-2) infections are associated with increased risk of hiv transmission. we determined hsv-2 prevalence, incidence and associated risk factors, incidence among persons with indeterminate results, and prevalence of hsv-2/hiv co-infection among young adults (18-34 years) and adolescents (16-17 years) enrolled in an hiv incidence cohort study in western kenya. | 2017 | 28586396 |
| herpes simplex virus type 2 myelitis: case report and review of the literature. | non-traumatic myelopathies can result from a wide spectrum of conditions including inflammatory, ischemic, and metabolic disorders. here, we describe the case of a 60-year old immunocompetent woman who developed acute back pain followed by rapidly ascending flaccid tetraparesis, a c6 sensory level, and sphincter dysfunction within 8 h. acyclovir and steroids were started on day 2 and herpes simplex virus type 2 (hsv-2) was confirmed by polymerase chain reaction in cerebrospinal fluid. magnetic r ... | 2017 | 28539913 |
| erratum to: precision of the kalon herpes simplex virus type 2 igg elisa: an international inter-laboratory assessment. | 2017 | 28525965 | |
| racial/ethnic disparities at the end of an hiv epidemic: persons who inject drugs in new york city, 2011-2015. | to examine whether racial/ethnic disparities persist at the "end of the hiv epidemic" (prevalence of untreated hiv infection < 5%; hiv incidence < 0.5 per 100 person-years) among persons who inject drugs (pwid) in new york city. | 2017 | 28520494 |
| sexual network drivers of hiv and herpes simplex virus type 2 transmission. | hiv and herpes simplex virus type 2 (hsv-2) infections are sexually transmitted and propagate in sexual networks. using mathematical modeling, we aimed to quantify effects of key network statistics on infection transmission, and extent to which hsv-2 prevalence can be a proxy of hiv prevalence. | 2017 | 28514276 |
| migrating microbes: what pathogens can tell us about population movements and human evolution. | the biology of human migration can be observed from the co-evolutionary relationship with infectious diseases. while many pathogens are brief, unpleasant visitors to human bodies, others have the ability to become life-long human passengers. the story of a pathogen's genetic code may, therefore, provide insight into the history of its human host. the evolution and distribution of disease in africa is of particular interest, because of the deep history of human evolution in africa, the presence o ... | 2017 | 28511559 |
| surgical excision for recurrent herpes simplex virus 2 (hsv-2) anogenital infection in a patient with human immunodeficiency virus (hiv). | recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (hiv), of whom approximately 5% develop resistance to acyclovir. we present a case of a 49-year-old man with hiv who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. he initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. the lesion progressed to a large hypertrophic mass that required surgical exc ... | 2017 | 28508238 |
| determining the igm and igg antibodies titer against hsv1, hsv2 and cmv in the serum of schizophrenia patients. | schizophrenia is a destructive clinical syndrome with diverse mental pathologies. different mechanisms and factors have a role in this disease. a possible mechanism is that teratogenic viruses cause brain changes and results in the disease appearance. the schizophrenia patients were diagnosed by psychologists and with the consent of patients, five cc of venous blood was drawn. than serum samples were isolated and immunoglobulin m (igm) and immunoglobulin g (igg) antibodies against herpes simplex ... | 2017 | 29036805 |
| herpesviruses in etiopathogenesis of aggressive periodontitis: a meta-analysis based on case-control studies. | previous studies have found that herpesviruses are associated with aggressive periodontitis (agp). however, these findings are controversial. this meta-analysis was aimed at clarifying the association between herpesviruses and agp. | 2017 | 29036216 |
| a trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model. | an estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (hsv-2), the most common cause of genital ulcer disease. some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. a vaccine was developed that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (vzv), a closely related member of the herpesvirid ... | 2017 | 28481687 |
| [investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods]. | in this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (pcr) methods. patients hospitalized with central nervous system infections between april 2012 and february 2014 were enrolled in the study. demographic and clinical information of the patients were collected prospectively. cerebrospinal fluid (csf) samples of the ... | 2017 | 28929964 |
| a herpes simplex virus type 2-encoded microrna promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer. | certain viruses use micrornas to regulate the expression of their own genes, host genes, or both. a number of micrornas expressed by herpes simplex virus type 2 have been confirmed by previous studies. however, whether these micrornas play a role in the metastasis of lung cancers and how these viral micrornas precisely regulated the tumor biological process in lung cancer bone metastasis remain obscure. we recently identified the high expression of an acutely and latently expressed viral microrn ... | 2017 | 28468588 |
| herpes simplex virus type 2 acquisition among hiv-1-infected adults treated with tenofovir disoproxyl fumarate as part of combination antiretroviral therapy: results from the actg a5175 pearls study. | tenofovir disoproxyl fumarate (tdf) disoproxyl fumarate (tdf) has in vitro activity against herpes simplex virus type 2 (hsv-2) and reduced hsv-2 acquisition as preexposure prophylaxis. whether tdf-containing antiretroviral therapy (art) reduces hsv-2 acquisition is unknown. | 2017 | 28453835 |
| vaccination to reduce reactivation of herpes simplex virus type 2. | 2017 | 28453833 | |
| acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: a case report and review of the literature. | a 55-year-old man was admitted to our hospital for investigation of high fever, decreased consciousness and bilateral visual impairment. his cerebrospinal fluid analysis revealed pleocytosis of mononuclear cells and an increased protein concentration. flair images revealed multiple high-intensity lesions in the frontal lobe, part of which was enhanced with gadolinium. despite initiating treatment with acyclovir and corticosteroids, his consciousness and visual acuity deteriorated. immunopatholog ... | 2017 | 28450685 |
| correction for mahic et al., "maternal immunoreactivity to herpes simplex virus 2 and risk of autism spectrum disorder in male offspring". | [this corrects the article doi: 10.1128/msphere.00016-17.]. | 2017 | 28435887 |
| reply to magaret and wald, "autism link to herpes simplex virus 2 antibody in pregnancy likely to be spurious". | 2017 | 28409568 | |
| autism link to herpes simplex virus 2 antibody in pregnancy likely to be spurious. | 2017 | 28405628 | |
| associations between friendship characteristics and hiv and hsv-2 status amongst young south african women in hptn-068. | prevalence of hiv among young women in south africa remains extremely high. adolescent peer groups have been found to be an important influence on a range of health behaviours. the characteristics of young women's friendships might influence their sexual health and hiv risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. we investigated associations between young women's friendships and their herpes simplex virus type 2 (hsv-2) a ... | 2017 | 29285883 |
| dual-strain genital herpes simplex virus type 2 (hsv-2) infection in the us, peru, and 8 countries in sub-saharan africa: a nested cross-sectional viral genotyping study. | quantitative estimation of the extent to which the immune system's protective effect against one herpes simplex virus type 2 (hsv-2) infection protects against infection with additional hsv-2 strains is important for understanding the potential for hsv-2 vaccine development. using viral genotyping, we estimated the prevalence of hsv-2 dual-strain infection and identified risk factors. | 2017 | 29281620 |
| extracts of equisetum giganteum l and copaifera reticulate ducke show strong antiviral activity against the sexually transmitted pathogen herpes simplex virus type 2. | equisetum giganteum l and copaifera reticulate ducke have been traditionally used by women of the tacana tribe in the bolivian amazonas for genital hygiene and for treatment of genital infection/inflammation. | 2017 | 28807852 |
| multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of hiv-1 and hsv-2 infections in vitro. | sexually transmitted infections affect hundreds of millions of people worldwide. both human immunodeficiency virus (hiv-1 and -2) and herpes simplex virus-2 (hsv-2) remain incurable, urging the development of new prevention strategies. while current prophylactic technologies are dependent on strict user adherence to achieve efficacy, there is a dearth of delivery vehicles that provide discreet and convenient administration, combined with prolonged-delivery of active agents. to address these need ... | 2017 | 28797967 |
| rubella, herpes simplex virus type 2 and preeclampsia. | preeclampsia is a major health problem. although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia. | 2017 | 28747200 |
| seminal vesicle fluid increases the efficacy of intravaginal hsv-2 vaccination. | once considered merely as a vehicle for spermatozoa, it is now clear that seminal plasma (sp) induces a variety of biological actions on the female reproductive tissues able to modulate the immune response against paternal antigens. to our knowledge, the influence of sp on the immune response against sexually transmitted pathogens has not been yet evaluated. we here analyzed whether the seminal vesicle fluid (svf), which contributes almost 60% of the sp volume in mice, could modulate the immune ... | 2017 | 28745327 |
| validation of a membrane touch biosensor for the qualitative detection of igg class antibodies to herpes simplex virus type 2. | a novel type of biosensor was assessed for application to the qualitative determination of circulating antibodies to herpes simplex virus type 2 (hsv-2). the device utilises a high activity hsv-2 type specific gg2 antigen for antibody capture and commercially available elisa reagents. the study compares the diagnostic performance of a prototype hsv-2 biochip to well-established in vitro tests routinely applied in clinical procedures. a panel of human serum samples (n = 60) previously characteris ... | 2017 | 28708188 |
| nuclear magnetic resonance (nmr) study for the detection and quantitation of cholesterol in hsv529 therapeutic vaccine candidate. | this study describes the nmr-based method to determine the limit of quantitation (loq) and limit of detection (lod) of cholesterol, a process-related impurity in the replication-deficient herpes simplex virus (hsv) type 2 candidate vaccine hsv529. three signature peaks from the 1d (1)h nmr of a cholesterol reference spectrum were selected for the identification of cholesterol. the loq for a cholesterol working standard was found to be 1 μg/ml, and the lod was found to be 0.1 μg/ml. the identity ... | 2017 | 28694932 |
| no role of herpes simplex virus type 2 (hsv-2) infection on hiv progression in naïve hiv patients | herpes simplex virus type 2 (hsv-2) is a common infection in human immunodeficiency virus (hiv) patients and may accelerate hiv progression by rising hiv viral load and decreasing cd4 count. however, the available data regarding the influence of hsv-2 seropositivity on hiv progression in hiv individuals are inconclusive. therefore, we aimed to determine hsv-2 seroprevalence in naïve hiv patients and normal controls and also investigate the relation of hiv viral load and cd4 count with hsv-2 sero ... | 2017 | 28688377 |
| sting is an essential mediator of the ku70-mediated production of ifn-λ1 in response to exogenous dna. | we previously identified ku70, a subunit of a dna repair protein complex, as a cytosolic dna sensor that induces the production of interferon-λ1 (ifn-λ1) by human primary cells and cell lines. ifn-λ1 is a type iii ifn and has similar antiviral activity to that of the type i ifns (ifn-α and ifn-β). we observed that human embryonic kidney (hek) 293t cells, which are deficient in the innate immune adaptor protein sting (stimulator of ifn genes), did not produce ifn-λ1 in response to dna unless they ... | 2017 | 28720717 |
| modelling infectious diseases with relapse: a case study of hsv-2. | herpes simplex virus type 2 (hsv-2) is one of the most common sexually transmitted diseases. although there is still no licensed vaccine for hsv-2, a theoretical investigation of the potential effects of a vaccine is considered important and has recently been conducted by several researchers. although compartmental mathematical models were considered for each special case in the previous studies, as yet there are few global stability results. | 2017 | 28716140 |
| highly conserved intragenic hsv-2 sequences: results from next-generation sequencing of hsv-2 ul and us regions from genital swabs collected from 3 continents. | understanding the variability in circulating herpes simplex virus type 2 (hsv-2) genomic sequences is critical to the development of hsv-2 vaccines. | 2017 | 28711653 |
| comparison of acyclovir and multistrain lactobacillus brevis in women with recurrent genital herpes infections: a double-blind, randomized, controlled study. | we performed a randomized double-blind controlled trial to compare the efficacy and safety of multistrain probiotic and acyclovir in women patients with recurrent genital herpes simplex virus type 2 (hsv-2) infections. eighty-one patients enrolled in the study were being treated with multistrain lactobacillus brevis one vaginal capsule every 12 h and oral acyclovir 400 mg twice daily for 6 months. of 53 patients who completed both treatment courses, no important differences were identified betwe ... | 2017 | 28852985 |
| a herpes simplex virus type 2 deleted for glycoprotein d enables dendritic cells to activate cd4(+) and cd8(+) t cells. | herpes simplex virus type 2 (hsv-2) is highly prevalent in the human population producing significant morbidity, mainly because of the generation of genital ulcers and neonatal encephalitis. additionally, hsv-2 infection significantly increases the susceptibility of the host to acquire hiv and promotes the shedding of the latter in the coinfected. despite numerous efforts to create a vaccine against hsv-2, no licensed vaccines are currently available. a long-standing strategy, based on few viral ... | 2017 | 28848543 |
| effect of hsv-2 infection on subsequent hiv acquisition: an updated systematic review and meta-analysis. | hiv and herpes simplex virus type 2 (hsv-2) infections cause a substantial global disease burden and are epidemiologically correlated. two previous systematic reviews of the association between hsv-2 and hiv found evidence that hsv-2 infection increases the risk of hiv acquisition, but these reviews are now more than a decade old. | 2017 | 28843576 |
| the us2 gene product of herpes simplex virus 2 modulates nf-κb activation by targeting tak1. | hsv-2 is one of the most common sexually transmitted pathogens worldwide and hsv-2 infection triggers cytokine and chemokine production. however, little is known about which hsv-2 genes engage in the regulation of nf-κb signaling and what mechanisms are involved. in a screen of the unique short (us) regions of hsv-2, we observed that hsv-2 us2 activates nf-κb signaling. we additionally indicated that deficiencies of us2 decrease hsv-2 wt mediated nf-κb activation and cytokine and chemokine produ ... | 2017 | 28827540 |
| seroprevalence of herpes simplex virus type-2 (hsv-2) among pregnant women who participated in a national hiv surveillance activity in haiti. | herpes simplex virus type 2 (hsv-2), one the most common causes of genital ulcers, appears to increase both the risk of hiv acquisition and hiv transmission. hsv-2/hiv co-infection among pregnant women may increase the risk of perinatal transmission of hiv. this study describes rates of hsv-2 among pregnant women in haiti and hsv-2 test performance in this population. | 2017 | 28821230 |
| interaction between herpesvirus entry mediator and hsv-2 glycoproteins mediates hiv-1 entry of hsv-2-infected epithelial cells. | herpes simplex virus type 2 (hsv-2) increases human immunodeficiency virus type 1 (hiv-1) acquisition and transmission via unclear mechanisms. herpesvirus entry mediator (hvem), an hsv-2 entry receptor, is highly expressed on hiv-1 target cells (cd4+ t cells) and may be incorporated into hiv-1 virions, while hsv-2 glycoproteins can be present on the infected cell surface. since hvem-gd interaction together with gb/gh/gl is essential for hsv-2 entry, hvem-bearing hiv-1 (hiv-1/hvem) may enter hsv- ... | 2017 | 28809154 |
| anti hsv-2 activity of peganum harmala (l.) and isolation of the active compound. | genital herpes is a sexually transmitted disease caused by herpes simplex virus type 2 (hsv-2). nucleoside analogues such as acyclovir (acv) are the usual therapy for treating hsv infection. however, the overuse of this drug has led to the emergence of resistant strains. therefore, the search for new alternative or complementary molecules to overcome this obstacle is needed. in this objective, peganum harmala was investigated for its hsv-2 activity. the organic extracts of the different plant or ... | 2017 | 29223449 |
| low cd4 cells and viral co-infection increase the risk of vain: use of scca1 and ki67 as diagno-prognostic biomarkers. | this study evaluated the correlation of scca1, ki67 and cd4 cell expressions and classified vaginal smears in individuals co-infected with human immunodeficiency virus (hiv), herpes simplex virus 2 (hsv2), epstein barr virus (ebv) and human papilloma virus (hpv). this crossectional study included 173 participants within the age range of 20-70 years. vaginal smears were stained by papanicolaou technique and classified into high-grade squamous cell intraepithelial lesion (hsil), low-grade squamous ... | 2017 | 29269193 |
| effectiveness of early antiviral therapy in disseminated neonatal herpes simplex virus 2 (hsv-2) with fulminant hepatic failure. | background liver failure in the neonatal population is a life-threatening complication and has a wide array of etiologies, including infectious, immune-mediated, metabolic, or drug-induced. although neonatal herpes simplex virus (hsv) hepatitis only accounts for 1% of all acute liver failures, it has an extremely aggressive clinical course that carries a mortality rate of 85%. case report we report a rare case of disseminated neonatal hsv-2 with late presentation associated with fulminant liver ... | 2017 | 28392553 |
| pregnancy outcomes in association with stds including genital hsv-2 shedding in a south african cohort study. | genital herpes simplex virus-2 (hsv-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes. | 2017 | 28396556 |
| hiv prevalence and associated risk factors among men who have sex with men in dar es salaam, tanzania. | limited studies and differential risk behaviours among men who have sex with men(msm) in africa calls for population specific studies. we present results from the largest integrated bio-behavioural survey among msm in africa to inform programming. | 2017 | 29140871 |
| prospective cohort study showing persistent hsv-2 shedding in women with genital herpes 2 years after acquisition. | herpes simplex virus type 2 (hsv-2) is a prevalent infection with great variability in clinical and virological manifestations among individuals. this prospective cohort study aims to evaluate the natural history of hsv-2 reactivation in the genital area in the same group of women over time. | 2017 | 29175899 |
| pharmacological induction of heme oxygenase-1 impairs nuclear accumulation of herpes simplex virus capsids upon infection. | heme oxygenase-1 (ho-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ros), as well as cytokines, among others. its activity can be positively modulated by cobalt protoporphyrin (copp) and negatively by tin protoporphirin (snpp). once induced, ho-1 degrades iron-containing heme into ferrous iron (fe2+), carbon monoxide (co) and biliverdin. importantly, numerous products of ho- ... | 2017 | 29163402 |
| the role of fungi in the etiology of multiple sclerosis. | multiple sclerosis (ms) is a chronic inflammatory disorder of the central nervous system. infectious triggers of ms are being actively investigated. substantial evidence supports the involvement of the epstein-barr virus (ebv), though other viruses, bacteria, protists, and fungi are also being considered. many links between fungi and diseases involving chronic inflammation have been found recently. evidence linking ms and fungi is reviewed here. the hla-drb1*15 allele group is the most important ... | 2017 | 29085329 |
| association between virus exposure and depression in us adults. | mood disorders are common mental illnesses. among the factors associated with major depression are exposures to infectious diseases including hepatitis c, influenza, varicella-zoster, and herpes viruses. in this study, we sought to evaluate further associations between viral exposure and depression. from the us center for disease control's national health and nutrition examination survey, we obtained data about depression status, antidepressant use, exposure to hepatitis a, hepatitis b, herpes s ... | 2017 | 29287239 |
| molecular evolution of herpes simplex virus 2 complete genomes: comparison between primary and recurrent infections. | herpes simplex virus 1 (hsv-1) and hsv-2 are large, double-stranded dna viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. how hsv evolves within an infected individual experiencing multiple episodes of recurrent disease over time is not known. we determined the genome sequences of viruses isolated from two subjects in the herpevac trial for women who experienced primary hsv-2 genital disease and compared them with sequences of viruses ... | 2017 | 28931680 |
| association between infection burden and adult height. | although highly heritable, adult height is also associated with numerous environmental factors, including exposure to infection. particularly in developing regions of the world, infection burden appears to slow growth during childhood. using a large database representative of the us population, we examined associations between adult height and leg length and an infection-burden index based on past exposure to toxocara species, toxoplasmosis gondii, cytomegalovirus, hepatitis a, hepatitis b, hepa ... | 2017 | 28926748 |
| [herpes simplex virus infection: an overview of the problem, pharmacologic therapy and dietary measures]. | treatment of infectious diseases remains one of the principal research target for many researchers and healthcare providers worldwide. herpes simplex virus 1 (hsv-1) and herpes simplex virus 2 (hsv-2) are common human pathogens with an estimated 60-95% of the adult population infected by at least one of them. the worldwide disease burden of hsv is substantial, and acyclovir and related nucleoside analogues (viral dna polymerase inhibitors) as therapies have led to significantly increased treatme ... | 2017 | 28914066 |
| performance of commercial enzyme-linked immunoassays for diagnosis of herpes simplex virus-1 and herpes simplex virus-2 infection in a clinical setting. | us food and drug administration-approved enzyme-linked immunoassays (eia) for determining type-specific herpes simplex virus (hsv) serostatus are widely used in clinical practice. we compared the performance of such assays with the university of washington western blot (uw wb) in patients who sought confirmation of their hsv serology result. | 2017 | 28876290 |
| strong associations between national prevalence of various stis suggests sexual network connectivity is a common underpinning risk factor. | if national peak human immunodeficiency virus (hiv) prevalence is positively associated with the prevalence of other sexually transmitted infections (stis) from before or early on in the hiv epidemics this would suggest common underlying drivers. | 2017 | 29025419 |
| novel role for interleukin-17 in enhancing type 1 helper t cell immunity in the female genital tract following mucosal herpes simplex virus 2 vaccination. | it is well established that interferon gamma (ifn-γ) production by cd4+ t cells is critical for antiviral immunity against herpes simplex virus 2 (hsv-2) genital infection. however, the role of interleukin-17a (il-17a) production by cd4+ t cells in hsv-2 antiviral immunity is yet to be elucidated. here we demonstrate that il-17a plays an important role in enhancing antiviral t helper type 1 (th1) responses in the female genital tract (fgt) and is essential for effective protection conferred by h ... | 2017 | 28956763 |
| invasive obstetric procedures and cesarean sections in women with known herpes simplex virus status during pregnancy. | neonatal herpes is a potentially devastating infection that results from acquisition of herpes simplex virus (hsv) type 1 or 2 from the maternal genital tract at the time of vaginal delivery. current guidelines recommend (1) cesarean delivery if maternal genital hsv lesions are present at the time of labor and (2) antiviral suppressive therapy for women with known genital herpes to decrease hsv shedding from the genital tract at the time of vaginal delivery. however, most neonatal infections occ ... | 2017 | 29308404 |
| real time pcr to evaluate hsv-2 shedding from anal and genital samples among men who have sex with men, living with hiv. | this study shows the relative quantification of hsv-2 by qpcr, using the miqe guidelines. the reaction efficiency was evaluated, and the relative quantification used the r = 2-δcq method. the relative quantification of hsv-2 was conducted with anal and genital samples from men who have sex with men (msm), living with hiv. the presence of a single amplification product was validated with a dissociation curves profile and the determination of the melting temperature. the limit of detection for β-g ... | 2017 | 29236293 |
| modeling hiv disease progression and transmission at population-level: the potential impact of modifying disease progression in hiv treatment programs. | mathematical models that incorporate hiv disease progression dynamics can estimate the potential impact of strategies that delay hiv disease progression and reduce infectiousness for persons not on antiretroviral therapy (art). suppressive treatment of hiv-positive persons co-infected with herpes simplex virus-2 (hsv-2) with valacyclovir, an hsv-2 antiviral, can lower hiv viral load, but the impact of partially-suppressive valacyclovir relative to fully-suppressive art on population hiv transmis ... | 2017 | 29223580 |
| education, early screening and treatment of stis could reduce infertility among women in kenya. | in kenya, sexually transmitted infections (stis) such as chlamydia trachomatis, neisseria gonorrhoea, hiv, herpes simplex virus type 2 (hsv-2), syphilis and trichomoniasis tend to be prevalent, especially in women. further, the research shows that women who test positive for stis (other than hiv), have little knowledge of these infections. of particular concern, is that there has been little attention on the part of government to educate the general public about stis, yet these diseases can have ... | 2017 | 29209488 |
| hiv and herpes simplex virus type 2 epidemiological synergy: misguided observational evidence? a modelling study. | to investigate whether observational studies of hiv and herpes simplex virus type 2 (hsv-2) infections have the capacity to assess the hiv/hsv-2 epidemiological synergy. | 2017 | 29203577 |
| atypical presentation of herpes simplex virus type 2 infection refractory to treatment with acyclovir in 2 hematologic patients. | herpesvirus infections are not uncommon in hematologic patients. our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with acyclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. the second patient, diagnosed with follicular hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with acyclovir but that responded to intralesional cidofovir ... | 2017 | 29203034 |
| us6 gene deletion in herpes simplex virus type 2 enhances dendritic cell function and t cell activation. | herpes simplex virus (hsv) type 1 (hsv-1) and type 2 (hsv-2) produce lifelong infections that are associated with frequent asymptomatic or clinically apparent reactivation. importantly, hsv express multiple virulence factors that negatively modulate innate and adaptive immune components. notably, hsv interfere with dendritic cell (dc) viability and function, likely hindering the capacity of the host to mount effective immunity against these viruses. recently, an hsv-2 virus that was deleted in g ... | 2017 | 29176979 |
| [co-infections of hiv, syphilis and hsv-2 among men who have sex with men at the voluntary hiv counseling and testing clinics in shanghai]. | objective: to understand the prevalence rates of hiv-syphilis and hiv-herpes simplex virus 2 (hsv-2) co-infections and related factors among men having sex with men (msm) who had visited the voluntary hiv counseling and testing (vct) clinics in shanghai, china. methods: 756 eligible msm who attended the vct clinics of shanghai municipality and putuo district during march to august, 2015 were recruited to participate in a cross-sectional survey with questionnaire interview and blood testing for h ... | 2017 | 29060980 |
| antiviral effects of lactobacillus crispatus against hsv-2 in mammalian cell lines. | herpes simplex virus type 2 (hsv-2) infectious disease is one of the most common viral sexually transmitted diseases. as regards, vaginal lactobacilli play an important role in protecting host against the urogenital pathogens; here we assessed the potential antiviral activity of lactobacillus crispatus against hsv-2 infection in vitro. | 2017 | 29037754 |
| optimized enzyme-linked immunosorbent assay for detecting cytomegalovirus infections during clinical trials of recombinant vaccines. | in clinical trials of cytomegalovirus (cmv) glycoprotein b (gb) vaccines, cmv infection is detected by first depleting serum of anti-gb antibodies and then measuring anti-cmv antibodies with a commercially available enzyme-linked immunosorbent assay (elisa) kit, with confirmation of positive findings by immunoblot. | 2017 | 29035763 |
| association between male circumcision and women's biomedical health outcomes: a systematic review. | male circumcision reduces men's risk of acquiring hiv and some sexually transmitted infections from heterosexual exposure, and is essential for hiv prevention in sub-saharan africa. studies have also investigated associations between male circumcision and risk of acquisition of hiv and sexually transmitted infections in women. we aimed to review all evidence on associations between male circumcision and women's health outcomes to benefit women's health programmes. | 2017 | 29025633 |
| carbosilane dendrons with fatty acids at the core as a new potential microbicide against hsv-2/hiv-1 co-infection. | herpes simplex virus type 2 (hsv-2) and human immunodeficiency virus type 1 (hiv-1) represent the two most frequent sexually transmitted infections (sti) worldwide. epidemiological studies suggest that hsv-2 increases the risk of hiv-1 acquisition approximately 3-fold mainly due to the clinical and immunological manifestations. in the absence of vaccines against both sti, the development of new preventive strategies has become essential for further studies. we performed the screening of six nove ... | 2017 | 29090302 |
| network analysis of the hominin origin of herpes simplex virus 2 from fossil data. | herpes simplex virus 2 (hsv2) is a human herpesvirus found worldwide that causes genital lesions and more rarely causes encephalitis. this pathogen is most common in africa, and particularly in central and east africa, an area of particular significance for the evolution of modern humans. unlike hsv1, hsv2 has not simply co-speciated with humans from their last common ancestor with primates. hsv2 jumped the species barrier between 1.4 and 3 mya, most likely through intermediate but unknown homin ... | 2017 | 28979799 |
| differences in health-related quality of life between hiv-positive and hiv-negative people in zambia and south africa: a cross-sectional baseline survey of the hptn 071 (popart) trial. | the life expectancy of hiv-positive individuals receiving antiretroviral therapy (art) is approaching that of hiv-negative people. however, little is known about how these populations compare in terms of health-related quality of life (hrqol). we aimed to compare hrqol between hiv-positive and hiv-negative people in zambia and south africa. | 2017 | 28964756 |
| biologic interactions between hsv-2 and hiv-1 and possible implications for hsv vaccine development. | development of a safe and effective vaccine against herpes simplex virus type 2 (hsv-2) has the potential to limit the global burden of hsv-2 infection and disease, including genital ulcer disease and neonatal herpes, and is a global sexual and reproductive health priority. another important potential benefit of an hsv-2 vaccine would be to decrease hiv infections, as hsv-2 increases the risk of hiv-1 acquisition several-fold. acute and chronic hsv-2 infection creates ulcerations and draws dendr ... | 2017 | 28958807 |
| prevalent herpes simplex virus-2 increases the risk of incident bacterial vaginosis in women from south africa. | studies have shown that women diagnosed with herpes simplex virus-2 (hsv-2) have a higher risk for bacterial vaginosis (bv) infection. we investigated the presence of hsv-2 infections as a risk factor for incident bv infections in high risk, human immunodeficiency virus (hiv) uninfected women enrolled in a hiv prevention trial in durban, south africa. the vaginal and oral interventions to control the epidemic trial was a multicentre, double blinded, randomized controlled trial which was designed ... | 2017 | 28956191 |
| seropositivity to herpes simplex virus type 2, but not type 1 is associated with cervical cancer: nhanes (1999-2014). | herpes simplex virus types 1 and 2 (hsv1 and hsv2) are infectious agents, and their association with cancer occurrence in human is a controversial topic for decades. we addressed this subject using all available continuous national health and nutrition examination survey (nhanes) cross-sectional data from 1999 to 2014. | 2017 | 29115946 |