Publications

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thermally enhanced radiosensitivity of cultured chinese hamster cells. 19724506201
the in vivo cytogenetic effects of 252 cf on liver and bone marrow of the chinese hamster. 19725084001
the retention, distribution, dose and cytogenetic effects of 241 amacitrate in the chinese hamster. 19725083994
damage and repair of dna in 5-bromodeoxyuridine-labeled chinese hamster cells exposed to fluorescent light.illumination of chinese hamster cells with fluorescent light after 5-bromodeoxyuridine incorporation leads to extensive single-strand breakage in the dna of the exposed cells. the rate of production of single-strand breaks is dependent on the extent to which thymine is replaced by 5-bromouracil. at least some of the breaks observed with alkaline gradients are probably produced in vivo and are probably not contingent upon alkaline hydrolysis since breakage can be demonstrated with neutral gradien ...19725063839
a genetic approach to the study of cytotoxicity and resistance of cultured chinese hamster cells in the presence of cytosine arabinoside. 19725065146
evidence for linkage of 3-phosphoglycerate kinase, hypoxanthine-guanine-phosphoribosyl transferase, and glucose 6-phosphate dehydrogenase loci in chinese hamster cells studied by using a relationship between gene multiplicity and enzyme activity. 19725064956
effects of cold treatment on synchronous chinese hamster cells treated in mitosis. 19724672339
fractions of chinese hamster dna differing in their content of guanine+cytosine and evidence for the presence of single-stranded dna. 19724340342
mutations to 8-azaguanine resistance induced in cultured chinese hamster cells by alpha particles. 19725064768
repair of a dna complex from x-irradiated chinese hamster cells. 19724541706
mammalian cells with altered forms of rna polymerase ii.mutants of chinese hamster ovary cells that are resistant to alpha-amanitin can be isolated. at least some of these mutants contain an altered form of dna-dependent rna polymerase ii, as indicated by its resistance to alpha-amanitin. these results indicate that mutation to alpha-amanitin resistance involves a change of a structural gene.19724508306
streptozotocin-diabetes in the chinese hamster. blood glucose and structural changes during the first 24 hours. 19724120450
the influence of lichen extracts on vicia faba and chinese hamster cells. 19724673674
expression of galactose genes in mammalian cells. i. galactose enzymes in chinese hamster ovary cell hybrids. 19725065777
effects of deprivation of two essential amino acids on dna synthesis in chinese hamster cells. 19724673146
survival curves and age response functions for chinese hamster cells exposed to x-rays or high let alpha-particles. 19724672846
actinomycin d inhibition of repair of a dna complex from chinese hamster cells. 19724541782
8-azaguanine resistance in mammalian cells. i. hypoxanthine-guanine phosphoribosyltransferase.chinese hamster cells were treated with ethyl methanesulfonate or n-methyl-n'-nitro-n-nitrosoguanidine, and mutants resistant to 8-azaguanine were selected and characterized. hypoxanthine-guanine phosphoribosyltransferase activity of sixteen mutants is extremely negative, making them suitable for reversion to hgprtase(+). ten of the extremely negative mutants revert at a frequency higher than 10(-7) suggesting their point mutational character. the remaining mutants have demonstrable hgprtase act ...19724345996
opposite effects of dibutyryl adenosine 3':5' cyclic monophosphate and serum on growth of chinese hamster cells. 19724344775
a practical method for production breeding of chinese hamsters (cricetulus griseus). 19724343330
banding patterns of chinese hamster chromosomes. 19724119150
regulation of glutamine synthetase in cultured chinese hamster cells. induction and repression by glutamine. 19724403489
biological damage from intranuclear tritium: dna strand breaks and their repair.isotopic decay in tritiated thymidine in the dna of frozen (-196 degrees c) chinese hamster cells causes breaks in dna strands to accumulate at a rate of 2.1 breaks per decay. after dna is thawed the tritium-induced breaks repair rapidly with a half-time of 15 minutes at 37 degrees c. in comparison to breakage by x-rays, the efficiency of dna strand breakage by tritium is equivalent to 0.48 rad per decay. this dose per decay is close to that predicted by simple dosimetric considerations (0.38 ra ...19725055946
tumorigenicity and agglutination by concanavalin a of chinese hamster cells and their hybrids. 19724661093
radiation mortality in the chinese hamster, cricetulus griseus, in relation to age. 19725056748
mutagenesis in cultured mammalian cells. ii. induction of gene mutations in chinese hamster cells. 19725053588
a method for comparing effects of different synchronizing protocols on mammalian cell cycle traverse. the traverse perturbation index.after treatment of chinese hamster cells (line cho) with various protocols for synchrony induction, the subsequent ability of cells to traverse the cell cycle (i e., to perform, an essential cell cycle process) has been determined by measurement of the dna distribution pattern among cells in large populations with the los alamos flow microfluorometer in the cultures prepared by the various synchronizing techniques the vast majority of cells traversed the cell cycle in a normal fashion; however, ...19725044762
studies on the structure of metaphase and interphase chromatin of chinese hamster cells by circular dichroism and thermal denaturation. 19724632121
occurrence and properties of a chromatin-associated f1-histone phosphokinase in mitotic chinese hamster cells. 19724347703
potentiation of drug effect by tween 80 in chinese hamster cells resistant to actinomycin d and daunomycin. 19725030820
[chromosome analysis of cultures of chinese hamster cells after treatment with lead acetate]. 19725062073
chromosome pulverization in micronuclei induced by tritiated thymidine.cultures of a pseudodiploid cell line (don) of chinese hamster origin were exposed to varying doses of tritiated thymidine (tdr-(3)h) for relatively long periods of time. in addition to previously observed chromosomal aberrations) such as breaks and reunions, a substantial number of interphasic cells with micronuclei and of metaphases associated with pulverized chromosomes was found; both phenomena were dependent on exposure time to and concentration of tdr-(3)h. the former phenomenon appeared t ...19725061680
relation between ultrastructure and viability of frozen-thawed chinese hamster tissue-culture cells. 19725045646
a two-factor hypothesis of freezing injury. evidence from chinese hamster tissue-culture cells. 19725045639
[behavioral ontogenesis of the chinese dwarf hamster, cricetulus griseus (milne edwards, 1867)]. 19725040089
[chinese hamster (cricetulus griseus): a spontaneously diabetic animal]. 19725029365
asynchronous centromere division in the chinese hamster. 19725024687
drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant chinese hamster cells in vitro. 19725007683
the effect of cyclamate and saccharin on the chromosomes of a chinese hamster cell line. 19724680637
differential spiralization along mammalian mitotic chromosomes. i. budr-revealed differentiation in chinese hamster chromosomes. 19724672290
the development of the diencephalon of the chinese hamster. an investigation of the validity of the criteria of subdivision of the brain. 19724540788
chromosomes of six primary sarcomas induced in the chinese hamster by 7,12-dimethylbenz(a)anthracene. 19724376140
[micronucleus test and chromosomal analysis in somatic and gonosomal cells of the chinese hamster after treatment with cyclophosphamide (author's transl)]. 19724130849
chromosome identification in a chinese hamster pseudodiploid cell line (chef-125). 19724116209
banding patterns of chinese hamster chromosomes revealed by new techniques. 19724112624
replicon origins in chinese hamsters cell dna. i. labeling procedure and preliminary observations. 19724263528
[malignant cellular transformation and karyologic modifications: the contribution of intraspecific somatic hybridization in chinese hamsters]. 19724676768
in vitro leucocyte cultures of syrian and chinese hamsters. 19725064119
cellular reactions of o6-methylguanine, a product of some alkylating carcinogens.cultures of a purine-requiring mutant of chinese hamster ovary cells (cho-104b), randomly bred hamster embryo cells, or escherichia coli b(s-1) were treated with non-toxic doses of (3)h-labelled o(6)-methylguanine. dna and rna were isolated and subjected to enzymic digestion to nucleosides at ph8. the products of digestion were analysed by ion-exchange chromatography on columns of dowex 50 (nh(4) (+) form) at ph8.9. no (3)h-labelled o(6)-methylguanosine was detected in nucleic acid digests. (3)h ...19734590203
surface antigens of mammalian cells as genetic markers. ii.a second surface antigen, b(l), lethal in the presence of specific antibody and complement has been identified on some human cells and shown to behave as a good genetic marker. it is autosomal, unlinked to the human a(l) antigen previously described, and unlinked to 15 other human genes. the a(l) antigen, which is linked to the lactic dehydrogenase a gene, is found on the hela, the cultured human fibroblast, and in small amounts on the human lymphocyte. b(l) occurs on hela cells, on cultured hum ...19734736830
[the development of cell classes in the liver of rats and chinese hamsters (author's transl)]. 19734777261
the heterogeneous distribution of acid hydrolases within a homogeneous population of cultured mammalian cells.1. chinese-hamster ovary fibroblasts were cultured to provide a homogeneous cell population. homogenates obtained from these cells were fractionated by centrifugation techniques and the resulting fractions were analysed for protein and for enzymes representative of certain subcellular particles. 2. unlike those in rat liver homogenates, the mitochondrial and lysosomal populations proved impossible to separate by differential centrifugation owing to the similarity of their sedimentation propertie ...19734353380
proline biosynthesis: multiple defects in chinese hamster ovary cells. 19734356052
a temperature-sensitive function in a chinese hamster line affecting dna synthesis. 19734359532
cytological mapping of the genes assigned to the human a 1 chromosome by use of radiation-induced chromosome breakage in a human-chinese hamster hybrid cell line. 19734785162
cell-cycle-dependent variations of deoxyribonucleoside triphosphate pools in chinese hamster cells. 19734795783
effect of amino acid and serum deprivation on the regulation of rna synthesis in cultured chinese hamster ovary cells. 19734796172
a comparison of the interaction of chinese hamster fibroblasts with human and bovine transferrins, and conalbumin (chick-egg transferrin). 19734796207
independent loss of human hexosaminidases a and b in man-chinese hamster somatic cell hybrids. 19734737100
a cytological study of the karyotype of spleen cells from scrapie-affected chinese hamsters. 19734738622
comparative studies of organs in the european hamster (cricetus cricetus l.), the syrian golden hamster (mesocricetus auratus w.) and the chinese hamster (cricetulus griseus m.). 19734779674
nature of the iron requirement for chinese hamster v79 cells in tissue culture medium. 19734734766
relationship between the ratio of parental chromosomes and parental doubling times in chinese hamster-mouse somatic cell hybrids. 19734736587
caffeine inhibition of postreplication repair of n-acetoxy-2-acetylaminofluorene-damaged dna in chinese hamster cells. 19734741935
asparagine-requiring tumor cell lines and their non-requiring variants: cytogenetics, biochemistry and population dynamics.asparagine-requiring jensen and walker rat tumor cells and their asparagine-independent variants have been analyzed. the following results were obtained: (1) both cell lines have very low levels of asparagine synthetase, and non-requiring revertants isolated from these lines have elevated levels of the enzyme. (2) no differences in chromosome number were detected between the parent jensen line and five jensen non-requiring revertants isolated from it. (3) both jensen and walker cells undergo asp ...19734798091
mutations affecting the structure of hypoxanthine: guanine phosphoribosyltransferase in cultured chinese hamster cells.14 clones resistant to 8-azaguanine, isolated from mutagenically treated cultured cells from chinese hamsters, were tested for loss of enzymic and immunological activities of hypoxanthine: guanine phosphoribosyltransferase. three of the clones had no enzymic activity but reacted strongly with antiserum prepared against the enzyme (crm(+)), indicating the presence of a defective enzyme protein, probably caused by a mutation in its structural gene. the other 11 mutants had little or no enzymic or ...19734119786
expression of endogenous rna c-type virus group-specific antigens in mammalian cells.highly sensitive and specific radioimmunoassays are described for quantitation of the intraspecies determinants of several mammalian c-type viral group-specific (gs) antigens. an interspecies (gs-3) immunoassay has been developed which has both the broad reactivity and great sensitivity necessary for detection of c-type viruses where intraspecies gs assays are not available. by using these immunoassays, the expression of endogenous virus-specified gs antigens in mammalian cells of different spec ...19734127032
microbial flora and viral contact status of chinese hamsters (cricetulus griseus). 19734357853
localization of genes on human chromosomes by studies of human-chinese hamster somatic cell hybrids. assignment of pgm3 to chromosome c6 and regional mapping of the pgd, pgm1 and pep-c genes on chromosome a1. 19734358963
[characterization of a hybrid cell line, "human leukemia-chinese hamster"]. 19734364713
expression of malignancy in interspecies chinese hamster x mouse cell hybrids. 19734355218
chromosome and chromatid exchanges in chinese hamster cells. 19734348023
transfer of genetic information by purified metaphase chromosomes.transfer of genetic information from isolated mammalian chromosomes to recipient cells has been demonstrated. metaphase chromosomes isolated from chinese hamster fibroblasts were incubated with mouse a(9) cells containing a mutation at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus. cells were plated in a selective medium, resulting in death of all unaltered parental a(9) cells. however, colonies of cells containing hypoxanthine phosphoribosyl transferase (ec 2.4.2.8) appeared ...19734515624
chromosomal interchanges induced by radiation in spermatogonial cells and leukocytes of mouse and chinese hamster. 19734515916
regional localization of loci for human pgm and 6pgd on human chromosome one by use of hybrids of chinese hamster-human somatic cells.the human gene loci phosphoglucomutase(1) (pgm(1), ec 2.7.5.1) and 6-phosphogluconate dehydrogenase (6pgd, ec 1.1.1.43), which are located on human chromosome one, have been assigned to a specific region of the short arm of that chromosome, by use of a hybrid cell line derived from a chinese hamster cell line deficient in hypoxanthine phosphoribosyl transferase and a strain of human diploid fibroblasts. cytogenetic analysis of a hybrid clone maintained for about 50 generations in vitro revealed ...19734517931
identification of chick chromosomes in cell hybrids formed between chick erythrocytes and adenine-requiring mutants of chinese hamster cells.when chick erythrocytes were fused with adenine-requiring mutants of chinese hamster cells of two different complementation classes and grown in adenine-free medium for 1 week or longer, mitotic cells were observed containing both chick and chinese hamster metaphase chromosomes within a single cell. stable hybrid clones were subsequently isolated that possessed, in addition to a complete chinese hamster genome, a single specific chick chromosome. hybrids resulting from fusions involving differen ...19734517942
mutagenicity and carcinogenicity of n-methyl-n'-nitro-n-nitrosoguanidine i. induction of chromosome aberrations and mitotic anomalies in chinese hamster ovary cells.cultured chinese hamster ovary (cho) cells were exposed to different concentrations of n-methyl-n'-nitro-n-nitrosoguanidine (mnng) for either 24 hr or 6 days. for cytological consequences of mnng exposure, cho cells were treated for 24 hr and allowed a 24 hr recovery period prior to analysis; for the estimation of cytotoxicity of mnng, cells were treated for 6 days followed by a 6 day recovery period. the cytotoxic effect of mnng based on the colony-forming ability of treated cells showed a semi ...1973422929
isolation and characterization of revertants of the mammalian temperature sensitive leucyl-trna synthetase mutant tshl.nine spontaneous and seven ethyl methanesulfonate induced revertants of the chinese hamster ovary cell line mutant (tshl), which possesses a temperature sensitive leucyl-trna synthetase, were isolated and characterized with respect to growth rate, leucyl-trna synthetase activity and thermolability, intracellular leucine pool size, and rrna content. although most revertants had increased leucyl-trna synthetase activity, and of those tested, all but one had increased thermostability, each appears ...1973422661
enhanced intestinal fat absorption in diabetic chinese hamsters. 19734773551
effect of 2450-mhz microwaves on the radiation response of x-irradiated chinese hamsters. 19734703889
evidence for pleiotropic changes in lines of chinese hamster ovary cells resistant to concanavalin a and phytohemagglutinin-p.lines of chinese hamster ovary cells resistant to the lectins concanavalin a (con a) and phytohemagglutinin-p (pha-p) have been isolated and characterized. lines were isolated by a stepwise, a single-step, or a cycling single-step procedure, from both mutagen-treated and untreated cultures. the resistant lines showed a higher efficiency of colony formation in the presence of the appropriate lectin than did the wild-type parental line. the cell lines resistant to con a did not exhibit any detecta ...19734347206
initiation and continuation of dna replication are not associated with the nuclear envelope in mammalian cells.for determination of whether dna replication is initiated at the nuclear envelope, synchronized chinese hamster ovary cells labeled with [(3)h]thymidine were examined by electron microscope radioautography. the cells were synchronized initially by mitotic shake-off and held at the g(1)-s border by 5-fluorodeoxyuridine plus amethopterin. cells were fixed at 1, 5, 10, and 30 min after the inhibitors were counteracted with [(3)h]thymidine. radioautographic silver grains in each case were present ov ...19734268475
radiation-induced cycle delay in synchronized chinese hamster cells: comparison between dna synthesis and division. 19734695230
cytotoxicity and mutagenicity of ultraviolet irradiation as a function of the interval between split doses in cultured chinese hamster cells. 19734684406
relative radiosensitivities of tetraploid and diploid chinese hamster cells in culture exposed to ionizing radiation. 19734684404
caffeine potentiation of the chromosome damage produced in bean root tips and in chinese hamster cells by various chemical and physical agents. 19734684403
cytogenetic and mutagenic effects of ddt and dde in a chinese hamster cell line. 19734346226
unscheduled dna synthesis and repair replication in uv-irradiated chinese-hamster cells. 19734122930
the effect of inhibitors of rna and protein synthesis on dibutyryl cyclic amp mediated morphological transformations of chinese hamster ovary cells in vitro. 19734347524
[expression of tumorigenic potential in isologous hybrid clones of chinese hamster cells (author's transl)]. 19734790834
photoreactivation of ultraviolet-induced chromosomal aberrations.ultraviolet induces only chromatid-type aberrations in synchronized g(1) v-79 chinese hamster and a8w243 xenopus tissue culture cells. posttreatment with white light prevents expression of most potential aberrations in the a8 toad cell, which possesses a photoreactivation enzyme. we conclude that the major ultraviolet-induced dna lesion leading to chromosomal aberrations is the pyrimidine dimer.19734682133
determination of the cell cycle by microautoradiographic method in the cells of bone marrow in the chinese hamster in vivo. 19734805256
caffeine, caffeine derivatives and chromosomal aberrations. vi. the influence of temperature on the aberration-frequency induced during prophase and late g2 by 8-methoxycaffeine and 8-chlorocaffeine in chinese hamster cells. 19734798690
cell membrane permeability during the cell generation cycle in chinese hamster ovary cells. 19734797788
[mutagenic effect of o-methylhydroxylamine in chinese hamster cell cultures]. 19734807121
the response of chinese hamster (ovary) cells to protracted irradiation from 252cf and 60co. 19734761145
dna synthesis and mitosis in a temperature sensitive chinese hamster cell line. 19734798033
letter: damage and repair of dna in 5-bromodeoxyuridine-labeled chinese hamster cells exposed to fluorescent light. 19734796887
isolation and properties of a glucosamine-requiring mutant of chinese hamster lung cells. 19734788622
[synchronization of chinese hamster cell cultures with colcemid]. 19734781678
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