Publications

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quantitative aspects of the repair of alkylated dna in cultured mammalian cells. ii. non-semiconservative dna synthesis ('repair synthesis') in hela and chinese hamster cells following treatment with alkylating agents. 19715156326
quantitative aspects of the repair of alkylated dna in cultured mammalian cells. i. the effect on hela and chinese hamster cell survival of alkylation of cellular macromolecules. 19715156325
[obtaining isolated metaphase chromosomes from chinese hamster cells growing in vitro]. 19715105426
morphological transformation of chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone.treatment of chinese hamster ovary cells in vitro with dibutyrl adenosine cyclic 3':5'-monophosphate converts the culture from one of compact, randomly oriented cells that grow in multilayers to a monolayer of elongated, fibroblast-like cells growing parallel to one another. testosterone propionate, which has a similar though smaller effect at high concentrations and after prolonged incubation, potentiates the action of dibutyryl cyclic amp even when added at very low concentrations. the transfo ...19714322607
[hybridization between 2 cell lines of the chinese hamster with different tumorigenic powers]. 19714995370
a technique for increasing the number of mitoses in the bone marrow of the chinese hamster by injection of pertussis vaccine and phytohemagglutinin. 19715578204
differential response of constitutive and facultative heterochromatin in the manifestation of mitomycin induced chromosome aberrations in chinese hamster cells in vitro. 19715574765
[mutability of the functional morphology of the x-chromosomes in long-term cultures of chinese hamster cells]. 19715567692
chemical mutagenesis. the chinese hamster bone marrow as an in vivo test system. i. cytogenetic results on basic aspects of the methodology, obtained with alkylating agents. 19715545035
metaphase chromosome aberrations in chinese hamster liver cells in vivo after single acute 60co exposure. 19715539705
effect of chronic exposure to 60 co on the frequency of metaphase chromosome aberrations in the liver cells of the chinese hamster (in vivo). 19715316701
heat-induced lethality and chromosomal damage in synchronized chinese hamster cells treated with 5-bromodeoxyuridine. 19715316696
radiation-induced age-response changes in chinese-hamster cells. evidence for a new form of damage and its repair. 19715315438
variation in sensitivity to heat shock during the cell-cycle of chinese hamster cells in vitro. 19715314347
caffeine, caffeine derivatives and chromosomal aberrations. iv. synergism between mitomycin c and caffeine in chinese hamster cells. 19715173426
caffeine, caffeine derivatives and chromosomal aberrations. iii. the atp-dependence of the production of chromosomal aberrations by 8-ethoxycaffeine in chinese hamster cells at 17 degrees c. 19715173425
caffeine, caffeine derivatives and chromosomal aberrations. ii. different responses of allium root tips and chinese hamster cells to treatments with caffeine, 8-ethoxycaffeine and 6-methylcoumarin. 19715173419
isolation of aneusomic clones from chinese hamster cell line following induction of nondisjunction. 19715169526
mammalian cell genetics. 3. characterization of x-ray-induced forward mutations in chinese hamster cell cultures. 19715104862
[hormonally controlled sex dimorphism in skin patterns of the chinese hamster]. 19715096327
chromosome-breaking capacity of tepa and analogues in vicia faba and chinese hamster cells. 19714142011
architecture of the chinese hamster metaphase chromosome. 19714101995
spatial distribution of biological effect n a 3.9-gev nitrogen ion beam.a beam of nitrogen ions obtained with the princeton particle accelerator was used for the irradiation of chinese hamster (m3-1) cells in monolayer culture. the 3.9-billion-electron-volt (gev) beam passed along the monolayer, so that ions were stopped in the culture. a sharply defined zone of extensive cell destruction occurred in the last centimeter of the beam path.19715133729
[hybridization of mammalian somatic cells and spermatozoa. penetration and early morphological changes of stallion spermatozoa in chinese hamster cells]. 19714325612
induction of nuclear envelopes around metaphase chromosomes after fusion with interphase cells.the process of cellular fusion induced by sendai virus in chinese hamster cells (don line) afforded us the opportunity to study nuclear envelope formation around metaphase sets in the presence of interphase nuclei, when chromosome pulverization failed to occur in such multinucleate cells. morphologically, the enveloped metaphase chromosomes resembled a normal telophase nucleus, though minor differences prompted us to call it telophase-like. electron microscopic observations demonstrated that the ...19714329517
enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--chinese hamster somatic cell hybrids. 19714331030
genetics of somatic mammalian cells: lethal antigens as genetic markers for study of human linkage groups.the antigen that causes killing of at least 98% of a human cell population treated with a 1% solution of a specific rabbit antiserum in the presence of complement is a sensitive genetic marker. the rapid loss of human chromosomes in human-chinese hamster cell hybrids makes possible a convenient test of linkage relationships with this marker. hybrid clones with and without the lethal antigen were isolated and analyzed. in 76 clones and subclones studied, 41 carried both the lethal antigen and the ...19714332008
integration of simian virus 40 deoxyribonucleic acid into the deoxyribonucleic acid of primary infected chinese hamster cells.simian virus 40 deoxyribonucleic acid (dna) became associated in an alkaline-stable form with the dna of chinese hamster embryo cells at 15 to 20 hr post-infection, at the time when cell dna synthesis and t antigen were induced. the integration process was not inhibited by d-arabinosyl cytosine and was only partially inhibited by cycloheximide.19714332141
[comparative biochemical study on the diabetogenic effect of streptozotocin in mice, rats, chinese hamsters and guinea pigs]. 19714334222
reinitiation within one cell cycle of the deoxyribonucleic acid synthesis induced by simian virus 40.the infection of secondary cultures of chinese hamster cells with simian virus 40 (sv40) induces the appearance of cells with polyploid deoxyribonucleic acid (dna) content or chromosomal component within one cell generation. the mechanism of this phenomenon was studied by the use of 5-bromodeoxyuridine (budr) incorporation as a dna density marker. when cultures were treated with (14)c-budr and colcemide and harvested at 48 hr postinfection, only hybrid and light dna molecules were found in contr ...19714366428
wheat germ agglutinin titres of normal and transformed chinese hamster cells and human and guinea pig erythrocytes: variations related to cell preparation. 19714339592
experimental transmission of scrapie to voles and chinese hamsters. 19714099889
heparan sulfates of cultured cells. i. membrane-associated and cell-sap species in chinese hamster cells. 19714253009
effect of 5-bromodeoxyuridine on hyaluronic acid synthesis of a clonal hybrid line of mouse and chinese hamster in culture. 19714258000
[comparative morphological studies on the diabetogenic effect of streptozotocin in rats, chinese hamsters, guinea pigs and rabbits]. 19714258515
sedimentation of dna released from chinese hamster cells.under high ph and high salt conditions, chinese hamster cells lyse and release a dna-containing material of large molecular weight. with increasing lysis time, a smaller material is resolved from the large one. relative to t4 dna, the smaller is estimated to be approximately 2 x 10(8) daltons (number average). from a comparison of radiation data, the target size of the larger is about 15 times that of the smaller (probably a lower limit estimate). in addition to concentration of alkali, temperat ...19714997648
ultrastructural analysis of mitotic spindle elongation in mammalian cells in vitro. direct microtubule counts.the mitotic spindle of many mammalian cells undergoes an abrupt elongation at anaphase. in both cultured rat kangaroo (strain ptk(1)) and chinese hamster (strain don-c) fibroblasts, the distance from pole to pole at metaphase doubles during anaphase and telophase. in order to determine the organization and distribution of spindle microtubules during the elongation process, cells were fixed and flat embedded in epon 812. selected cells were photographed with the phase-contrast microscope and then ...19714939523
cytogenetic analysis of a chinese hamster-mouse hybrid cell. 19714940437
nucleoli of diploid cell strains. thei normal ultrastructure and the effects of toyocamycin and actinomycin d.nucleoli of cultured chinese hamster or mouse cells in early passages had a loosely reticular substructure. within the reticulum small, irregularly shaped, light fibrillar zones occurred which were contiguous with denser fibrillar zones. these denser zones appeared to be connected in some places to the particulate material which composed the mass of the nucleolus. generally, electron-transparent spaces separated the particulate zones from the fibrillar areas. treatment with toyocamycin, an agent ...19715104724
distinctive characteristics of nucleoli of two established cell lines.nucleoli of cultured cells of the established lines kb and l were found to possess a distinctive fine structural organization. the major portion of the nucleolar volume was composed of compact, particulate material. spheroidal fibrillar zones about 0.4 micro in diameter occurred within the particulate mass. these fibrillar zones had a central light area and a denser rim. toyocamycin treatment, which sharply inhibited the appearance of newly synthesized rna in the cytoplasm, caused the gradual di ...19715104725
x-linkage of human phosphoglycerate kinase confirmed in man-mouse and man-chinese hamster somatic cell hybrids. 19715132070
resistance of chinese hamsters to hymenolepis microstoma and its reversal by immunosuppression. 19715157159
induction of alkaline phosphatase by 5-bromodeoxyuridine in a hybrid line between mouse and chinese hamster in culture. 19715170775
mammalian peptide chain termination. ii. codon specificity and gtpase activity of release factor.in vitro peptide chain termination with release factor preparations from rabbit reticulocytes, guinea pig liver, or chinese hamster liver is directed with uaaa, uaga, or ugaa, suggesting that uaa, uag, and uga are terminator condons for mammalian cells. purified release factor from rabbit reticulocytes has ribosomaldependent gtpase activity, which is stimulated by uaaa. gtp hydrolysis appears requisite for in vitro peptide chain termination in mammals.19715276771
cytogenetic effects of cyclohexylamine and n-oh-cyclohexylamine on human leucocytes and chinese hamster bone marrow. 19715283624
loss of human genetic markers in man--chinese hamster somatic cell hybrids. 19715286856
chemical mutagenesis. the chinese hamster bone marrow as an in vivo test system. ii. correlation with in vitro results on chinese hamster fibroblasts and human fibroblasts and lymphocytes. 19715545036
immune cytolysis in relation to the growth cycle of chinese hamster cells. 19715560386
comparative analysis of mammalian sperm motility.spermatozoa of several mammalian species were studied by means of high-speed cinematography and electron microscopy. three types of motile patterns were observed in mouse spermatozoa. the first type involved an asymmetrical beat which seemed to propel the sperm in circular paths. the second type involved rotation of the sperm and appeared to allow them to maintain straight paths. in the third type of pattern, the sperm appeared to move by crawling on surfaces in a snakelike manner. spermatozoa o ...19725025110
further studies on the induction of alkaline phosphatase by 5-bromodeoxyuridine in a hybrid line between mouse and chinese hamster in culture. 19725063668
comparison of the retention and distribution of injected 252 cf in rats and chinese hamsters. 19725084000
evidence for linkage between human loci for 6-phosphogluconate dehydrogenase and phosphoglucomutase in man-chinese hamster somatic cell hybrids. 19724553635
cytofluorometric study of the deoxyribonucleoprotein of mouse spermatozoa early after fusion with chinese hamster cells. 19724584671
induction of alkaline phosphatase by cyclic amp or its dibutyryl derivative in a hybrid line between mouse and chinese hamster in culture. 19724108192
repopulation of the postmitotic nucleolus by preformed rna.this study is concerned with the fate of the nucleolar contents, particularly nucleolar rna, during mitosis mitotic cells harvested from monolayer cultures of chinese hamster embryonal cells, kb6 (human) cells, or l929 (mouse) cells were allowed to proceed into interphase in the presence or absence (control) of 0.04-0 08 microg/ml of actinomycin d, a concentration which preferentially inhibits nucleolar (ribosomal) rna synthesis 3 hr after mitosis, control cells had large, irregularly shaped nuc ...19724112854
loss of simian virus 40 dna-rna hybrids from nitrocellulose membranes; implications for the study of virus--host dna interactions.complete hybrids of simian virus 40 (sv40)dna and its complementary rna (crna) are not retained on nitrocellulose membranes. at saturating crna concentrations, retention of the hybrids indicates incomplete homology between dna and rna, probably due to incorporation of host dna in the viral dna; this effect is most pronounced when dna is produced in cells infected at high multiplicity. hybrids between dna of chinese hamster cells transformed by sv40 and crna are retained if the dna fragments are ...19724340749
translation of reovirus messenger rnas synthetesized in vitro into reovirus polypeptides by several mammalian cell-free extracts.single-stranded reovirus rna, synthesized in vitro by reovirus cores, functioned as messenger rna in cell-free extracts prepared from several mammalian cells: krebs ii mouse ascites cells, mouse l cells, chinese hamster ovary cells, hela cells, and rabbit reticulocytes. as shown by acrylamide gel electrophoresis, all eight polypeptides known to be specified by reovirus were synthesized in the reticulocyte system. in the other extracts, from 5 to 7 complete virus proteins were made.19724506788
genetics of somatic mammalian cells: demonstration of a human esterase activator gene linked to the adeb gene.prototrophic hybrids formed from an adenine-requiring chinese hamster cell and human fibroblasts uniformly display new esterase activity that differs from that of either parental cell in electrophoretic mobility and substrate specificity. the hybrids that grew in the selective medium and possessed the new esterase activity had a single extra chromosome that resembled a b-group human chromosome. when clones of such hybrid cells were cultured in nonselective medium, they rapidly reverted to inabil ...19724508320
inoculation of voles, chinese hamsters, gerbils and guinea-pigs with scrapie brain material. 19725065061
mutagenesis in cultured mammalian cells. i. spontaneous gene mutations in human and chinese hamster cells. 19725065687
[karyological characteristics of a mixed population during spontaneous hybridization of chinese hamster and mouse cells]. 19724637820
synchronous replication of the parental chromosomes in a chinese hamster-mouse somatic hybrid. 19724673832
tumor etiology and chromosome pattern.fibrosarcomas induced in chinese hamsters and rats by rous sarcomla virus and 7,12-dimethylbenz(a)anthracene are associated with nonrandom chromosome variation. although histologically indistinguishable, the tumors induced by the virus or chemical in each host species are characterized by completely different karyotypic patterns.19724338345
ribonucleic acid synthesis of vesicular stomatitis virus. iv. transcription by standard virus in the presence of defective interfering particles.exposure of vesicular stomatitis virus-infected chinese hamster ovary cells to cycloheximide results in the complete transcription of virion ribonucleic acid (rna) into only 28s and 13 to 15s viral-specific rna species. these rna are identical to viral messenger rna by the following criteria: size, single-strandedness, complementarity to virion rna, and formation of messenger ribonucleoproteins. this transcription represents the intracellular enzymatic activity of the virion-associated polymeras ...19724338638
f1-histone modification at metaphase in chinese hamster cells. 19724338680
ganglioside composition of malignant and actinomycin d-resistant nonmalignant chinese hamster cells. 1972444244
[transformation in vitro of a new cell line from the chinese hamster embryo (c.h.e.): evolution of the transplantability, the karyotype and the cell surface]. 19724622417
lymphocyte cultures from chinese hamster (cricetulus griseus). 19724111089
recovery and repair in chinese hamster cells following uv-irradiation. 19725066419
[topography of the peritoneal organs of the chinese minihamster (cricetulus griseus milne edwards 1867)]. 19725063830
cell cycle compartment analysis of chinese hamster cells in stationary phase cultures. 19725062785
studies on the structure of metaphase and interphase chromatin of chinese hamster cells by circular dichroism and thermal denaturation. 19724632121
occurrence and properties of a chromatin-associated f1-histone phosphokinase in mitotic chinese hamster cells. 19724347703
on the selection for the modal chromosome number in chinese hamster cells. 19724675123
polyploidy induced by x-rays during the cell cycle of chinese hamster cells in vitro. 19724674993
the effects of 144 ce- 144 pr on the metaphase chromosomes of the chinese hamster liver cells in vivo. 19724646441
alteration of nucleoside transport of chinese hamster cells by dibutyryl adenosine 3':5'-cyclic monophosphate.cultured chinese hamster ovary cells showed no significant change in generation time or fraction in the s-phase in the presence of 1 mm n(6),o(2')-dibutyryl adenosine 3':5'-cyclic monophosphate. growth continued for at least two generations after expression of the morphological transformation induced by this cyclic amp analog. despite identical growth rates, apparent rates of dna and rna synthesis (incorporation of [(3)h]-thymidine or [(3)h]uridine) were reduced up to 15-fold in log phase by 1 m ...19724345504
changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous chinese hamster cells. 19724674589
enhancement of x-ray damage in synchronous chinese hamster cells by hypertonic treatments. 19724674588
repair of sublethal and potentially lethal x-ray damage in synchronous chinese hamster cells. 19724674587
growth dynamics of mitochondria in synchronized chinese hamster cells.the increase in cell volume (from electronic cell sizing) and the apportionment of this volume amongst the nuclear, cytoplasmic, and mitochondrial subcellular compartments (from electron microscopy) were studied throughout the cell division cycle in partially synchronized cultures of chinese hamster v79-s171 cells. average whole cell volume was found to increase smoothly, consistent with the doubling in one generation of individual cell volume. nuclear size increased in like fashion. mean total ...19724674506
reversible arrest of chinese hamster cells in g1 by partial deprivation of leucine. 19724673827
induction of auxotrophic mutations by treatment of chinese hamster cells with 5-bromodeoxyuridine and black light.treatment of an aneuploid chinese hamster cell line (v79) in tissue culture with 5-bromodeoxyuridine and black light, with or without prior exposure of cells to another mutagen, led to the isolation of auxotrophic mutants, each of which exhibits a specific nutritional requirement for glycine, uridine, purine, or for a combination of glycine, hypoxanthine, and thymidine. 61 mutants that could not use exogenous galactose were also isolated. thus, this treatment functions as an inductive, but not a ...19724508333
thermally enhanced radiosensitivity of cultured chinese hamster cells. 19724506201
the in vivo cytogenetic effects of 252 cf on liver and bone marrow of the chinese hamster. 19725084001
the retention, distribution, dose and cytogenetic effects of 241 amacitrate in the chinese hamster. 19725083994
damage and repair of dna in 5-bromodeoxyuridine-labeled chinese hamster cells exposed to fluorescent light.illumination of chinese hamster cells with fluorescent light after 5-bromodeoxyuridine incorporation leads to extensive single-strand breakage in the dna of the exposed cells. the rate of production of single-strand breaks is dependent on the extent to which thymine is replaced by 5-bromouracil. at least some of the breaks observed with alkaline gradients are probably produced in vivo and are probably not contingent upon alkaline hydrolysis since breakage can be demonstrated with neutral gradien ...19725063839
a genetic approach to the study of cytotoxicity and resistance of cultured chinese hamster cells in the presence of cytosine arabinoside. 19725065146
evidence for linkage of 3-phosphoglycerate kinase, hypoxanthine-guanine-phosphoribosyl transferase, and glucose 6-phosphate dehydrogenase loci in chinese hamster cells studied by using a relationship between gene multiplicity and enzyme activity. 19725064956
effects of cold treatment on synchronous chinese hamster cells treated in mitosis. 19724672339
fractions of chinese hamster dna differing in their content of guanine+cytosine and evidence for the presence of single-stranded dna. 19724340342
mutations to 8-azaguanine resistance induced in cultured chinese hamster cells by alpha particles. 19725064768
repair of a dna complex from x-irradiated chinese hamster cells. 19724541706
mammalian cells with altered forms of rna polymerase ii.mutants of chinese hamster ovary cells that are resistant to alpha-amanitin can be isolated. at least some of these mutants contain an altered form of dna-dependent rna polymerase ii, as indicated by its resistance to alpha-amanitin. these results indicate that mutation to alpha-amanitin resistance involves a change of a structural gene.19724508306
streptozotocin-diabetes in the chinese hamster. blood glucose and structural changes during the first 24 hours. 19724120450
the influence of lichen extracts on vicia faba and chinese hamster cells. 19724673674
expression of galactose genes in mammalian cells. i. galactose enzymes in chinese hamster ovary cell hybrids. 19725065777
effects of deprivation of two essential amino acids on dna synthesis in chinese hamster cells. 19724673146
survival curves and age response functions for chinese hamster cells exposed to x-rays or high let alpha-particles. 19724672846
actinomycin d inhibition of repair of a dna complex from chinese hamster cells. 19724541782
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