TitleAbstractYear(sorted ascending)
microphotometric and autoradiographic studies on the cell cycle and cell size during growth and decline of chinese hamster cell cultures. 19715104443
[studies on pregnancy and offspring of the spontaneously diabetic chinese hamster]. 19715108106
new class of purine mutants of chinese hamster ovary cells.mutants of chinese hamster ovary cells (cho/pro(-)) were isolated after mutagenesis with n-methylnitrosoguanidine and selection by the bromodeoxyuridine technique. six of these were mutants classified as purine-requiring. the metabolic block appears to be early in the purine biosynthetic pathway. the mutants do not appear to be genetically identical.19715547727
atp pool levels in synchronously growing chinese hamster cells. 19715555578
migration of newly synthesized rna during mitosis. ii. chinese hamster fibroblasts. 19715554033
molecular hybridization of chinese hamster 5s, 4s and "pulse-labelled" rna in cytological preparations. 19715554032
regulation of growth in chinese hamster cells by a local inhibitor. 19715554030
the response of chinese hamster cells to n-methyl-n'-nitro-n-nitrosoguanidine. 19715165147
[migration of newly synthesized rna during mitosis. ii. chinese hamster fibroblasts]. 19715105515
cellular resistance to daunomycin in chinese hamster cells in vitro. 19715102828
the establishment and chromosome analysis of a new cell line of chinese hamster from spontaneous transformation in vitro. 19715563334
hybridization of actinomycin d- and amethopterin-resistant chinese hamster cells in vitro. 19715547219
chromosomal aberrations and mortality of x-irradiated mammalian cells: emphasis on repair.chromosomal aberrations induced by x-rays in synchronized chinese hamster cells correlated well with mortality as the radiosensitivity was made to vary by a factor of 4 by treating the cells with colcemid or 5-bromodeoxyuridine and by irradiating the cells in different parts of the cell cycle. 37% survival was observed when the cells sustained about one aberration per cell. furthermore, the positive correlation was observed during repair of damage. repair was measured by the reduction in damage ...19715276778
[penetration of isolated metaphase chromosomes into chinese hamster tissue culture cells]. 19715105427
the effects of x-rays on the synthesis of dna, rna, and proteins in synchronized chinese hamster cells. 19715103339
deoxyribonucleic acid synthesis in ultraviolet-light-irradiated chinese hamster cells.two mammalian cell lines, chinese hamster ovary (cho) which can recover colony-forming ability between fractionated doses of ultraviolet light (uv), and chinese hamster b-14faf28 which cannot recover, were tested for the ability to bypass uv-induced photoproducts in dna during postirradiation dna synthesis. the molecular weight distributions of newly synthesized dna in uv-irradiated populations of both cell lines showed evidence for photoproduct bypass. hence, the bypass mechanism does not corre ...19715103274
homology between sv40 dna and dna of normal and sv40-transformed chinese hamster cells. 19715543953
[hybridization between 2 cell lines of the chinese hamster with different tumorigenic powers]. 19714995370
spatial distribution of biological effect n a 3.9-gev nitrogen ion beam.a beam of nitrogen ions obtained with the princeton particle accelerator was used for the irradiation of chinese hamster (m3-1) cells in monolayer culture. the 3.9-billion-electron-volt (gev) beam passed along the monolayer, so that ions were stopped in the culture. a sharply defined zone of extensive cell destruction occurred in the last centimeter of the beam path.19715133729
mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons.the cytotoxicity and mutagenicity of several polycyclic hydrocarbons and their k-region derivatives were tested in a clone of chinese hamster cells; the production of clones resistant to 8-azaguanine was used as the marker for mutagenesis. in the series related to benz(a)anthracene, the k-region epoxide was highly mutagenic, and the phenol was less mutagenic; the hydrocarbon and cis and trans-dihydrodiols were not mutagenic. seven resistant clones were isolated and retained their drug-resistance ...19715289256
comparative studies on the chinese hamster bone marrow after treatment with phenylbutazone and cyclophosphamide. 19715144633
evidence for linkage between glucose 6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyl transferase loci in chinese hamster cells. 19715116523
an ultracytochemical and ultrastructural study of epithelial cells in ductuli efferentes of chinese hamster. 19714111152
[hybridization of mammalian somatic cells and spermatozoa. penetration and early morphological changes of stallion spermatozoa in chinese hamster cells]. 19714325612
heparan sulfates of cultured cells. i. membrane-associated and cell-sap species in chinese hamster cells. 19714253009
effect of 5-bromodeoxyuridine on hyaluronic acid synthesis of a clonal hybrid line of mouse and chinese hamster in culture. 19714258000
enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--chinese hamster somatic cell hybrids. 19714331030
[comparative biochemical study on the diabetogenic effect of streptozotocin in mice, rats, chinese hamsters and guinea pigs]. 19714334222
wheat germ agglutinin titres of normal and transformed chinese hamster cells and human and guinea pig erythrocytes: variations related to cell preparation. 19714339592
induction of nuclear envelopes around metaphase chromosomes after fusion with interphase cells.the process of cellular fusion induced by sendai virus in chinese hamster cells (don line) afforded us the opportunity to study nuclear envelope formation around metaphase sets in the presence of interphase nuclei, when chromosome pulverization failed to occur in such multinucleate cells. morphologically, the enveloped metaphase chromosomes resembled a normal telophase nucleus, though minor differences prompted us to call it telophase-like. electron microscopic observations demonstrated that the ...19714329517
genetics of somatic mammalian cells: lethal antigens as genetic markers for study of human linkage groups.the antigen that causes killing of at least 98% of a human cell population treated with a 1% solution of a specific rabbit antiserum in the presence of complement is a sensitive genetic marker. the rapid loss of human chromosomes in human-chinese hamster cell hybrids makes possible a convenient test of linkage relationships with this marker. hybrid clones with and without the lethal antigen were isolated and analyzed. in 76 clones and subclones studied, 41 carried both the lethal antigen and the ...19714332008
ultrastructural analysis of mitotic spindle elongation in mammalian cells in vitro. direct microtubule counts.the mitotic spindle of many mammalian cells undergoes an abrupt elongation at anaphase. in both cultured rat kangaroo (strain ptk(1)) and chinese hamster (strain don-c) fibroblasts, the distance from pole to pole at metaphase doubles during anaphase and telophase. in order to determine the organization and distribution of spindle microtubules during the elongation process, cells were fixed and flat embedded in epon 812. selected cells were photographed with the phase-contrast microscope and then ...19714939523
cytogenetic analysis of a chinese hamster-mouse hybrid cell. 19714940437
cytogenetic effects of cyclohexylamine and n-oh-cyclohexylamine on human leucocytes and chinese hamster bone marrow. 19715283624
nucleoli of diploid cell strains. thei normal ultrastructure and the effects of toyocamycin and actinomycin d.nucleoli of cultured chinese hamster or mouse cells in early passages had a loosely reticular substructure. within the reticulum small, irregularly shaped, light fibrillar zones occurred which were contiguous with denser fibrillar zones. these denser zones appeared to be connected in some places to the particulate material which composed the mass of the nucleolus. generally, electron-transparent spaces separated the particulate zones from the fibrillar areas. treatment with toyocamycin, an agent ...19715104724
distinctive characteristics of nucleoli of two established cell lines.nucleoli of cultured cells of the established lines kb and l were found to possess a distinctive fine structural organization. the major portion of the nucleolar volume was composed of compact, particulate material. spheroidal fibrillar zones about 0.4 micro in diameter occurred within the particulate mass. these fibrillar zones had a central light area and a denser rim. toyocamycin treatment, which sharply inhibited the appearance of newly synthesized rna in the cytoplasm, caused the gradual di ...19715104725
x-linkage of human phosphoglycerate kinase confirmed in man-mouse and man-chinese hamster somatic cell hybrids. 19715132070
chemical mutagenesis. the chinese hamster bone marrow as an in vivo test system. ii. correlation with in vitro results on chinese hamster fibroblasts and human fibroblasts and lymphocytes. 19715545036
immune cytolysis in relation to the growth cycle of chinese hamster cells. 19715560386
sedimentation of dna released from chinese hamster cells.under high ph and high salt conditions, chinese hamster cells lyse and release a dna-containing material of large molecular weight. with increasing lysis time, a smaller material is resolved from the large one. relative to t4 dna, the smaller is estimated to be approximately 2 x 10(8) daltons (number average). from a comparison of radiation data, the target size of the larger is about 15 times that of the smaller (probably a lower limit estimate). in addition to concentration of alkali, temperat ...19714997648
reinitiation within one cell cycle of the deoxyribonucleic acid synthesis induced by simian virus 40.the infection of secondary cultures of chinese hamster cells with simian virus 40 (sv40) induces the appearance of cells with polyploid deoxyribonucleic acid (dna) content or chromosomal component within one cell generation. the mechanism of this phenomenon was studied by the use of 5-bromodeoxyuridine (budr) incorporation as a dna density marker. when cultures were treated with (14)c-budr and colcemide and harvested at 48 hr postinfection, only hybrid and light dna molecules were found in contr ...19714366428
[comparative morphological studies on the diabetogenic effect of streptozotocin in rats, chinese hamsters, guinea pigs and rabbits]. 19714258515
integration of simian virus 40 deoxyribonucleic acid into the deoxyribonucleic acid of primary infected chinese hamster cells.simian virus 40 deoxyribonucleic acid (dna) became associated in an alkaline-stable form with the dna of chinese hamster embryo cells at 15 to 20 hr post-infection, at the time when cell dna synthesis and t antigen were induced. the integration process was not inhibited by d-arabinosyl cytosine and was only partially inhibited by cycloheximide.19714332141
experimental transmission of scrapie to voles and chinese hamsters. 19714099889
mammalian peptide chain termination. ii. codon specificity and gtpase activity of release vitro peptide chain termination with release factor preparations from rabbit reticulocytes, guinea pig liver, or chinese hamster liver is directed with uaaa, uaga, or ugaa, suggesting that uaa, uag, and uga are terminator condons for mammalian cells. purified release factor from rabbit reticulocytes has ribosomaldependent gtpase activity, which is stimulated by uaaa. gtp hydrolysis appears requisite for in vitro peptide chain termination in mammals.19715276771
loss of human genetic markers in man--chinese hamster somatic cell hybrids. 19715286856
resistance of chinese hamsters to hymenolepis microstoma and its reversal by immunosuppression. 19715157159
induction of alkaline phosphatase by 5-bromodeoxyuridine in a hybrid line between mouse and chinese hamster in culture. 19715170775
comparative analysis of mammalian sperm motility.spermatozoa of several mammalian species were studied by means of high-speed cinematography and electron microscopy. three types of motile patterns were observed in mouse spermatozoa. the first type involved an asymmetrical beat which seemed to propel the sperm in circular paths. the second type involved rotation of the sperm and appeared to allow them to maintain straight paths. in the third type of pattern, the sperm appeared to move by crawling on surfaces in a snakelike manner. spermatozoa o ...19725025110
induction of alkaline phosphatase by cyclic amp or its dibutyryl derivative in a hybrid line between mouse and chinese hamster in culture. 19724108192
repopulation of the postmitotic nucleolus by preformed rna.this study is concerned with the fate of the nucleolar contents, particularly nucleolar rna, during mitosis mitotic cells harvested from monolayer cultures of chinese hamster embryonal cells, kb6 (human) cells, or l929 (mouse) cells were allowed to proceed into interphase in the presence or absence (control) of 0.04-0 08 microg/ml of actinomycin d, a concentration which preferentially inhibits nucleolar (ribosomal) rna synthesis 3 hr after mitosis, control cells had large, irregularly shaped nuc ...19724112854
synchronous replication of the parental chromosomes in a chinese hamster-mouse somatic hybrid. 19724673832
evidence for linkage between human loci for 6-phosphogluconate dehydrogenase and phosphoglucomutase in man-chinese hamster somatic cell hybrids. 19724553635
cytofluorometric study of the deoxyribonucleoprotein of mouse spermatozoa early after fusion with chinese hamster cells. 19724584671
ribonucleic acid synthesis of vesicular stomatitis virus. iv. transcription by standard virus in the presence of defective interfering particles.exposure of vesicular stomatitis virus-infected chinese hamster ovary cells to cycloheximide results in the complete transcription of virion ribonucleic acid (rna) into only 28s and 13 to 15s viral-specific rna species. these rna are identical to viral messenger rna by the following criteria: size, single-strandedness, complementarity to virion rna, and formation of messenger ribonucleoproteins. this transcription represents the intracellular enzymatic activity of the virion-associated polymeras ...19724338638
f1-histone modification at metaphase in chinese hamster cells. 19724338680
loss of simian virus 40 dna-rna hybrids from nitrocellulose membranes; implications for the study of virus--host dna interactions.complete hybrids of simian virus 40 (sv40)dna and its complementary rna (crna) are not retained on nitrocellulose membranes. at saturating crna concentrations, retention of the hybrids indicates incomplete homology between dna and rna, probably due to incorporation of host dna in the viral dna; this effect is most pronounced when dna is produced in cells infected at high multiplicity. hybrids between dna of chinese hamster cells transformed by sv40 and crna are retained if the dna fragments are ...19724340749
further studies on the induction of alkaline phosphatase by 5-bromodeoxyuridine in a hybrid line between mouse and chinese hamster in culture. 19725063668
inoculation of voles, chinese hamsters, gerbils and guinea-pigs with scrapie brain material. 19725065061
mutagenesis in cultured mammalian cells. i. spontaneous gene mutations in human and chinese hamster cells. 19725065687
comparison of the retention and distribution of injected 252 cf in rats and chinese hamsters. 19725084000
genetics of somatic mammalian cells: demonstration of a human esterase activator gene linked to the adeb gene.prototrophic hybrids formed from an adenine-requiring chinese hamster cell and human fibroblasts uniformly display new esterase activity that differs from that of either parental cell in electrophoretic mobility and substrate specificity. the hybrids that grew in the selective medium and possessed the new esterase activity had a single extra chromosome that resembled a b-group human chromosome. when clones of such hybrid cells were cultured in nonselective medium, they rapidly reverted to inabil ...19724508320
[karyological characteristics of a mixed population during spontaneous hybridization of chinese hamster and mouse cells]. 19724637820
translation of reovirus messenger rnas synthetesized in vitro into reovirus polypeptides by several mammalian cell-free extracts.single-stranded reovirus rna, synthesized in vitro by reovirus cores, functioned as messenger rna in cell-free extracts prepared from several mammalian cells: krebs ii mouse ascites cells, mouse l cells, chinese hamster ovary cells, hela cells, and rabbit reticulocytes. as shown by acrylamide gel electrophoresis, all eight polypeptides known to be specified by reovirus were synthesized in the reticulocyte system. in the other extracts, from 5 to 7 complete virus proteins were made.19724506788
tumor etiology and chromosome pattern.fibrosarcomas induced in chinese hamsters and rats by rous sarcomla virus and 7,12-dimethylbenz(a)anthracene are associated with nonrandom chromosome variation. although histologically indistinguishable, the tumors induced by the virus or chemical in each host species are characterized by completely different karyotypic patterns.19724338345
ganglioside composition of malignant and actinomycin d-resistant nonmalignant chinese hamster cells. 1972444244
[transformation in vitro of a new cell line from the chinese hamster embryo (c.h.e.): evolution of the transplantability, the karyotype and the cell surface]. 19724622417
lymphocyte cultures from chinese hamster (cricetulus griseus). 19724111089
recovery and repair in chinese hamster cells following uv-irradiation. 19725066419
[topography of the peritoneal organs of the chinese minihamster (cricetulus griseus milne edwards 1867)]. 19725063830
cell cycle compartment analysis of chinese hamster cells in stationary phase cultures. 19725062785
chromosome pulverization in micronuclei induced by tritiated thymidine.cultures of a pseudodiploid cell line (don) of chinese hamster origin were exposed to varying doses of tritiated thymidine (tdr-(3)h) for relatively long periods of time. in addition to previously observed chromosomal aberrations) such as breaks and reunions, a substantial number of interphasic cells with micronuclei and of metaphases associated with pulverized chromosomes was found; both phenomena were dependent on exposure time to and concentration of tdr-(3)h. the former phenomenon appeared t ...19725061680
relation between ultrastructure and viability of frozen-thawed chinese hamster tissue-culture cells. 19725045646
a two-factor hypothesis of freezing injury. evidence from chinese hamster tissue-culture cells. 19725045639
[behavioral ontogenesis of the chinese dwarf hamster, cricetulus griseus (milne edwards, 1867)]. 19725040089
[chinese hamster (cricetulus griseus): a spontaneously diabetic animal]. 19725029365
asynchronous centromere division in the chinese hamster. 19725024687
drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant chinese hamster cells in vitro. 19725007683
the effect of cyclamate and saccharin on the chromosomes of a chinese hamster cell line. 19724680637
differential spiralization along mammalian mitotic chromosomes. i. budr-revealed differentiation in chinese hamster chromosomes. 19724672290
the development of the diencephalon of the chinese hamster. an investigation of the validity of the criteria of subdivision of the brain. 19724540788
chromosomes of six primary sarcomas induced in the chinese hamster by 7,12-dimethylbenz(a)anthracene. 19724376140
[micronucleus test and chromosomal analysis in somatic and gonosomal cells of the chinese hamster after treatment with cyclophosphamide (author's transl)]. 19724130849
chromosome identification in a chinese hamster pseudodiploid cell line (chef-125). 19724116209
banding patterns of chinese hamster chromosomes revealed by new techniques. 19724112624
alteration of nucleoside transport of chinese hamster cells by dibutyryl adenosine 3':5'-cyclic monophosphate.cultured chinese hamster ovary cells showed no significant change in generation time or fraction in the s-phase in the presence of 1 mm n(6),o(2')-dibutyryl adenosine 3':5'-cyclic monophosphate. growth continued for at least two generations after expression of the morphological transformation induced by this cyclic amp analog. despite identical growth rates, apparent rates of dna and rna synthesis (incorporation of [(3)h]-thymidine or [(3)h]uridine) were reduced up to 15-fold in log phase by 1 m ...19724345504
changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous chinese hamster cells. 19724674589
enhancement of x-ray damage in synchronous chinese hamster cells by hypertonic treatments. 19724674588
repair of sublethal and potentially lethal x-ray damage in synchronous chinese hamster cells. 19724674587
growth dynamics of mitochondria in synchronized chinese hamster cells.the increase in cell volume (from electronic cell sizing) and the apportionment of this volume amongst the nuclear, cytoplasmic, and mitochondrial subcellular compartments (from electron microscopy) were studied throughout the cell division cycle in partially synchronized cultures of chinese hamster v79-s171 cells. average whole cell volume was found to increase smoothly, consistent with the doubling in one generation of individual cell volume. nuclear size increased in like fashion. mean total ...19724674506
reversible arrest of chinese hamster cells in g1 by partial deprivation of leucine. 19724673827
induction of auxotrophic mutations by treatment of chinese hamster cells with 5-bromodeoxyuridine and black light.treatment of an aneuploid chinese hamster cell line (v79) in tissue culture with 5-bromodeoxyuridine and black light, with or without prior exposure of cells to another mutagen, led to the isolation of auxotrophic mutants, each of which exhibits a specific nutritional requirement for glycine, uridine, purine, or for a combination of glycine, hypoxanthine, and thymidine. 61 mutants that could not use exogenous galactose were also isolated. thus, this treatment functions as an inductive, but not a ...19724508333
thermally enhanced radiosensitivity of cultured chinese hamster cells. 19724506201
the in vivo cytogenetic effects of 252 cf on liver and bone marrow of the chinese hamster. 19725084001
the retention, distribution, dose and cytogenetic effects of 241 amacitrate in the chinese hamster. 19725083994
damage and repair of dna in 5-bromodeoxyuridine-labeled chinese hamster cells exposed to fluorescent light.illumination of chinese hamster cells with fluorescent light after 5-bromodeoxyuridine incorporation leads to extensive single-strand breakage in the dna of the exposed cells. the rate of production of single-strand breaks is dependent on the extent to which thymine is replaced by 5-bromouracil. at least some of the breaks observed with alkaline gradients are probably produced in vivo and are probably not contingent upon alkaline hydrolysis since breakage can be demonstrated with neutral gradien ...19725063839
a genetic approach to the study of cytotoxicity and resistance of cultured chinese hamster cells in the presence of cytosine arabinoside. 19725065146
evidence for linkage of 3-phosphoglycerate kinase, hypoxanthine-guanine-phosphoribosyl transferase, and glucose 6-phosphate dehydrogenase loci in chinese hamster cells studied by using a relationship between gene multiplicity and enzyme activity. 19725064956
effects of cold treatment on synchronous chinese hamster cells treated in mitosis. 19724672339
fractions of chinese hamster dna differing in their content of guanine+cytosine and evidence for the presence of single-stranded dna. 19724340342
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