Publications

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the chromosomes of forty-two primary rous sarcomas of the chinese hamster. 19684298639
observations on the propagation of chinese hamsters. 19684231922
[on the question of the genetic change in a rat ascites hepatoma by heterotransplantation in the chinese hamster]. 19674294378
localization of "spontaneous" and rous sarcoma virus-induced breakage in specific regions of the chromosomes of the chinese hamster. 19674296940
age dependency of tissue resistance to trichinella spiralis in chinese hamsters. 19676026861
histometric investigations on the testicular tissue of rats with alloxan diabetes and chinese hamsters with spontaneous diabetes. 19676071200
isolation and properties of hybrids between somatic mouse and chinese hamster cells. 19676077523
dna replication in chinese hamster ovary cells made permeable to nucleotides by tween-80 treatment.we have developed a method for permeabilizing cho cells to nucleotides under conditions which allow most cells to remain viable. permeabilized cells can carry out atp-dependent, semiconservative synthesis of dna. the data are consistent with the continuation of dna synthesis in those cells in s phase at the time of treatment, possibly limited to completion of replicon synthesis without new initiations.19671270517
ultrastructural study of the mitochondria in the skeletal muscle fibers in the diabetic chinese hamster.an ultrastructural study of skeletal muscle fiber biopsies from the tongue and soleus muscle of diabetic chinese hamsters revealed the presence of lipid droplets within the muscle fibers. these droplets often were found in the cyptoplasm near mitochondira, sometimes inside or surrounded by one or more mitochondria. glycogen granules were found in great quantities in the cytoplasm of the tongue and soleus muscle. granules which appeared to be glycogen were also found within the mitochondria of th ...1967276592
cytogenetic effects of 90sr on the bone marrow of chinese hamsters. lf-38. 19675302776
islet and beta cell volumes in diabetic chinese hamsters and their non-diabetic siblings. 19674907143
the colony of chinese hamsters of the c.h. best institute. a review of experimental work. 19674244685
distribution of dna in chinese hamster cells. 19676082327
comparison of radiation-induced chromatid aberrations in the testes and bone marrow of the chinese hamster. 19676065251
mitotic delay and chromosomal aberrations induced by x rays in synchronized chinese hamster cells in vitro.synchronized chinese hamster cell populations in vitro were x-irradiated at different stages of the cell cycle and examined at the next metaphase. mitotic delay varied according to the stage of the cell cycle at the time of irradiation. it was greatest for cells irradiated in middle to late s, moderate for cells irradiated in g2, and least for cells irradiated in g1. it increased approximately linearly with dose (0.7 hr./100 rad for s cells and 0.3 hr./100 rad for g1 cells). chromosomal aberrati ...196718623924
the effect of thymidine on the duration of g1 in chinese hamster cells.the generation time of a chinese hamster cell line was varied by the use of different lots of sera in the culture media. analysis of the division waves following thymidine synchronization showed that lengthening of the generation time was a result of an increase in duration of the g(1) phase and that thymidine treatment reduced the duration of g(1) back to its minimum value.19676061724
[the action of 5-fluoro-2'-deoxyuridine and aminopterin on the mitotic cycle in cell culture of chinese hamster]. 19676076533
differential effect of sodium azide on the incorporation of nucleic acid precursors into chinese hamster cells in vitro. 19676057886
generation cycle analysis of chinese hamster cells by a new method and its comparison with other methods. 19676038819
the absence of a detectable g1 phase in a cultured strain of chinese hamster lung cell. 19676035652
properties of mitotic cells prepared by mechanically shaking monolayer cultures of chinese hamster cells. 19674869346
rna synthesis in relation to dna replication in synchronized chinese hamster cell cultures. 19676050591
the effects of colcemid inhibition and reversal on the fine structure of the mitotic apparatus of chinese hamster cells in vitro. 19675339063
x-ray survival and dna synthesis in chinese hamster cells. i. the effect of inhibitors added before x-irradiation. 19675231591
[tumors in the forestomach of the chinese hamster following administration of diethylnitrosamine. a contribution to the problem of organotropy of a carcinogen]. 19676046493
synthesis of rna in mammalian cells during mitosis and interphase.chinese hamster cells in the mitotic and g(1) phases of the growth cycle were incubated for 30 or 60 min in suspension tissue culture and pulse-labeled with tritiated uridine. after appropriate chases, washes, and extractions, it was found that all incorporation into the nucleic acid may be accounted for by those cells in interphase. an average of 410 counts was found for incorporation into the cell population (approximately 2.0 x 10(5) cells) of which over 80% of the cells was initially in mito ...19676039370
persistence of chromosomal aberrations in chinese hamster thyroid following administration of iodine-131. 19676032617
regeneration of sialic acid on the surface of chinese hamster cells in culture. ii. incorporation of radioactivity from glucosamine-1-14c. 19676033950
diabetes mellitus in the chinese hamster. ii. the evolution of renal glomerulopathy. 19675630196
characterization of diabetes in the chinese hamster. 19675630193
the inheritance of diabetes in the chinese hamster. 19675630186
diabetes in the chinese hamster. some clinical and metabolic aspects. 19675621371
spontaneous diabetes mellitus in the chinese hamster: an electron microscopic study of the islets of langerhans. 19674907144
diabetes mellitus in the chinese hamster. i. metabolic and morphologic studies. 19674907137
insulin secretion in vitro by the pancreas of the chinese hamster. 19674907136
sulfur mustard and x-rays: differences in expression of lethal damage.before or after treatment with sulfur mustard, simple changes in the incubation conditions of cultured chinese hamster cells lead to changes as great as a factor of 6 in survival-curve slopes. with x-ray treatment, changes are similar but much smaller in magnitude. these results suggest that the modes of action of these agents are not entirely the same.19676020479
[in vitro transformation of chinese hamster cells by adenovirus 12: cytogenetic studies]. 19676039763
genetics of somatic mammalian cells. iv. properties of chinese hamster cell mutants with respect to the requirement for proline. 19676068403
contact inhibition in colony formation.contact inhibition of replication of the established mammalian cell line 3t3 was examined during growth of the colony and compared with that of the chinese-hamster cell line chl-1. the growth curves of cells in the colonies conformed to the predicted exponential and linear rates for chl-1 and 3t3 respectively. autoradiographs of colonies in which dna was labeled with tritiated thymidine showed that in 3t3 colonies, only peripheral cells were labeled, while chl-1 colonies were labeled throughout.19676066687
hydroxyurea: effects on chinese hamster cells grown in culture. 19676018562
[characteristics of the mitotic cycle in cultured cells of chinese hamster]. 19676064898
the pattern of autosomal dna replication in four tissues of the chinese hamster. 19676022325
some aspects on the blood glucose regulation and the glutathione content of the non-diabetic adult chinese hamster, cricetulus griseus. 19675597549
variation in relative lengths of early- and late- replicating portions of x chromosomes of the chinese hamster (cricetulus griseus). 19675587541
mitotic delay and chromosomal aberrations induced by x rays in synchronized chinese hamster cells in vitro. anl-7409. 19675308317
x-ray sensitivity of synchronized chinese hamster cells irradiated during hypoxia. anl-7409. 19675308301
the combined lethal effect of hydroxyurea and x-rays on chinese hamster cells in vitro. anl-7409. 19675308295
effect of cysteamine upon the x-ray response of chinese hamster cells during the generation cycle. anl-7409. 19675308212
ultraviolet sensitivity of synchronized chinese hamster cells at various stages of the cell cycle. anl-7409. 19675308198
chromosomal aberrations induced by tritiated thymidine during the s and g2 phases of chinese hamster cells. 19675299589
morphology of the pancreatic islets of the non-diabetic adult chinese hamster, cricetulus griseus. ultrastructural findings. 19674876559
morphology of the pancreatic islets of the non-diabetic adult chinese hamster, cricetulus griseus. light microscopical findings. 19674876558
a failure of specific inhibitors to affect survival of chinese hamster cells exposed to ultra-violet light. 19674171995
application of cell fractionation techniques in the study of cells infected with polyoma virus and newcastle disease virus.fisher, harold w. (university of rhode island, kingston), hidemi matsumiya, and masanobu azuma. application of cell fractionation techniques in the study of cells infected with polyoma virus and newcastle disease virus. j. bacteriol. 91:1645-1651. 1966.-techniques which permitted rigorous separation of nuclei and cytoplasm were applied to the study of the formation of newcastle disease virus (ndv) in an established line of chinese hamster cells and of polyoma virus (pyv) in mouse embryo fibrobla ...19664286455
persistent cyclic herpes simplex virus infection in vitro. 3. asynchrony in the progression of infection and cell regrowth.hampar, berge (national institute of dental research, bethesda, md.). persistent cyclic herpes simplex virus infection in vitro. iii. asynchrony in the progression of infection and cell regrowth. j. bacteriol. 91:1965-1970. 1966.-the progression of virus-induced cytopathic effects (cpe) and virus synthesis was studied in localized areas of chinese hamster cell cultures persistently infected with herpes simplex virus (hsv). cpe was initially evidenced by the presence of small multinucleated giant ...19664287257
segregation of sister chromatids in mammalian cells.segregation of sister chromatids in embryonic mouse cells in primary tissue culture is not random. in mitosis those chromatids replicated on a dna template synthesized during the preceding division cycle are separated from those constructed on a template synthesized two division cycles previously. segregation in cells of the chinese hamster follows a similar, but less pronounced, pattern.19665921385
free fatty acid metabolism in chinese hamsters. 19665938992
persistence of nucleoli in short term and long term cell cultures and in direct bone marrow preparations in mammalian materials.persistent nucleoli were studied in chinese hamster and human long term cultures, human peripheral blood short term cultures, as well as direct bone marrow preparations. no colchicine or hypotonic treatments were applied and the cells were differentially stained with the feulgen method and light green. nucleoli were found to persist in the three systems studied, although to a much greater extent in the long term culture. the persistent nucleolar materials were usually in the form of individualiz ...19665971647
[the effect of extracts from irradiated mouse bone marrow on chromosomes of chinese hamster cells cultivated in vitro]. 19665998216
some in vitro requirements of cells of c3h mouse, chinese hamster, green monkey, and human origin. 19664959128
mammalian chromosomes in vitro. xix. chromosomes of don-c, a chinese hamster fibroblast strain with a part of autosome 1b translocated to the y chromosome. 19665955044
x-ray sensitivity during the cell generation cycle of cultured chinese hamster cells. 19665924188
induction of thymine dimers in synchronized populations of chinese hamster cells. 19665970129
hyperinsulinemia with diabetes induced by cortisone, and the influence of growth hormone in the chinese hamster. 19665957189
cilia formation in chinese hamster fibroblasts in vitro as a response to colcemid treatment. 19665971010
life cycle analysis of mammalian cells. 3. the inhibition of division in chinese hamster cells by puromycin and actinomycin.analysis of the effects of actinomycin and puromycin on the g(2) and mitotic parts of the life cycle in chinese hamster ovary cells grown in suspension and synchronized by thymidine treatment has been carried out. rates of division of partially synchronized cell populations were measured in the presence and absence of the drugs, and various controls were performed to test for absence of complex side effects. actinomycin produces a block 1.9 hr before completion of division, while puromycin produ ...19665970563
regeneration of sialic acid on the surface of chinese hamster cells in culture. i. general characteristics of the replacement process. 19665967192
the kinetics of chromatid aberrations induced in chinese hamster cells by tritium-labeled thymidine. 19665920291
incorporation of [3-h]uridine and [m3-14-c]methionine into chinese-hamster cell ribonucleic acid. 19666006991
deoxyribonucleic acid replication of somatic cells in the chinese hamster. 19665914915
chronology of nucleic acid synthesis in meiosis of the male chinese hamster. 19665950863
cell cycle kinetics and radiation-induced chromosomal aberrations studied with c14 and h3 labels.chinese hamster cells in vitro were double labeled with c(14)tdr and h(3)tdr. at the time of irradiation with co(60) gamma rays (600 rad), the cells in the g(2) phase were labeled only with c(14), whereas cells in the late and middle s phases were labeled with both c(14) and h(3). the cells in early s phase were labeled only with h(3) and the g(1) cells were unlabeled. samples were fixed at various time intervals following irradiation and the metaphases were analyzed for chromosomal damage. the ...19665963459
metaphase arrest of chinese hamster cells with rotenone. 19665941244
radiosensitization of x chromosome of chinese hamster cells related to incorporation of 5-bromodeoxyuridine.selective incorporation of 5-bromodeoxyuridine into the late replicating arm of the x chromosome of chinese hamister cells cultured in vitro caused a selective radiosensization of the arm to ionizing radiation. radiation damage was observed as chromosomal aberrations, and incorporation was studied by using tritiated 5-bromodeoxyuridine.19665910191
hemogram of the chinese hamster. 19665959413
autoradiography of chromosomal dna fibers from chinese hamster cells. 19665221245
late-replicating chromosomal segments in aneuploid chinese hamster cell lines as determined by autoradiography. 19665909106
serum concentration: effects on cycle and x-ray sensitivity of mammalian cells.if the content of serum in the culture medium of exponentially growing chinese hamster cells is below optimum (15 percent), the doubling time and the resistance to x-irradiation of the cells are increased. in synchronously dividing populations the increase in doubling time is primarily caused by increase in duration of the postmitotic (g(1)) phase of the cells; this phase is relatively radiation resistant. the response of the cells growing synchronously is related quantitatively to the response ...19665902390
on the homology between the x and the y chromosomes of the chinese hamster. 19666004688
polycentric chromosomes induced by x-rays in giant cells of chinese hamster in vitro. 19665985313
the effect of 131-i on the aberration-rate of chromosomes from chinese hamster thyroids. 19665297017
division delay in hela cells in chinese hamster cells. a time-lapse study. 19665297015
[the differential carcinogenic effect of diethylnitrosamine in syrian and chinese hamsters]. 19665988952
serum proteins of chinese hamsters and response of diabetics to tolbutamide and insulin. 19665936460
production and characterization of multiple-layered populations of animal cells.dense populations containing 129 x 10(6) jensen sarcoma, 134 x 10(6) don chinese hamster, 28.9 x 10(6) wi-38 human diploid, 61.8 x 10(6) hep-2 human carcinoma, and 67.4 x 10(6) wish human amnion cells were produced from dilute inocula, 0.85 to 5.33 x 10(6), in 7 to 8 days in a perfusion system using replicate t-60 flasks. perfusion rates as high as 560 ml medium/day/t-60 were required to maintain ph (to ca +/-0.1 unit) and adequate nutrient supplies. the cell densities encountered are described ...19655884626
electronic separation of biological cells by volume.a device capable of separating biological cells (suspended in a conducting medium) according to volume has been developed. cell volume is measured in a coulter aperture, and the cells are subsequently isolated in droplets of the medium which are charged according to the sensed volume. the charged droplets then enter an electrostatic field and are deflected into a collection vessel. mixtures of mouse and human erythrocytes and a large volume component of mouse lymphoma cells were separated succes ...19655891056
mengovirus replication. 3. virus reproduction in chinese hamster ovary cells. 19654283990
mengovirus replication. iv. inhibition of chinese hamster ovary cell division as a result of infection with mengovirus. 19654283992
[inhibiting effect of mitoxantrone on cell cycle progression of chinese hamster ovary cells].the effect of mitoxantrone, a potential anticancer chemotherapeutic agent, on the cell cycle progression of chinese hamster ovary (cho) cells was investigated by microspectrophotometry. cho cells incubated with the agent for either 30 min or 24 h were inhibited, to various degrees, from proliferation. the inhibition appeared in dose dependent fashion. a 10-fold dose of the drug was required for the 30 min group, as compared to the 24h group, to develop an equivalent inhibiting effect. when expon ...19652094638
viruses and mammalian chromosomes. iv. replication of herpes simplex virus in diploid chinese hamster cells. 196514328610
synchronization of chinese hamster cells by reversal of colcemid inhibition. 19655325429
the fine structure of the nucleolus in mitotic divisions of chinese hamster cells in vitro.the nucleolus of chinese hamster tissue culture cells (strain dede) was studied in each stage of mitosis with the electron microscope. mitotic cells were selectively removed from the cultures with 0.2 per cent trypsin and fixed in either osmium tetroxide or glutaraldehyde followed by osmium tetroxide. the cells were embedded in both prepolymerized methacrylate and epon 812. thin sections of interphase nucleoli revealed two consistent components; dense 150-a granules and fine fibrils which measur ...19655884631
the nucleoli in mitotic divisions of mammalian cells in vitro.in a number of mammalian cell strains nucleoli persisted through mitosis. this phenomenon was especially pronounced in several cell lines derived from chinese hamster tissues. all the methods employed, including radioautography with tritiated uridine, cytochemical stains (methyl green-pyronin and azure b), fluorescent microscopy (coriphosphine o), ribonuclease digestion, and electron microscopy, demonstrated that the bodies identified as persistent nucleoli in the mitotic stages had the same cha ...19654222282
persistent herpes simplex virus infection in vitro with cycles of cell destruction and regrowth.hampar, berge (national institute of dental research, bethesda, md.), and mary lou copeland. persistent herpes simplex virus infection in vitro with cycles of cell destruction and regrowth. j. bacteriol. 90:205-212. 1965.-the susceptibility of two chinese hamster cell lines to herpes simplex virus (hsv) was studied from the time of their initiation through successive subcultures. the cells' susceptibility to the cytocidal effects of hsv decreased as the number of cell passages increased. during ...196516562018
the effects of micro-operations on the morphology, survival, and lysosomes of chinese hamster fibroblasts. 196514329382
quantitative tritium autoradiography of mammalian chromosomes. i. the basic method.a technique has been developed that allows repeated autoradiographs to be made of the isotope distribution in the chromosomes of a single cell. a series of 10 separate autoradiographs were made of a chinese hamster diploid male metaphase cell which had been labeled with tritiated thymidine during the first 15 minutes of its dna synthesis period in the previous interphase. each autoradiograph had low grain densities above the chromosomes so that quantitation was feasible. the separate autoradiogr ...19655840794
observations on the breeding and care of the chinese hamster, cricetulus griseus. 196514278298
some observations on nuclear budding and nuclear extrusions in a chinese hamster cell culture. 196514287282
x-ray and ultraviolet sensitivity of synchronized chinese hamster cells at various stages of the cell cycle.populations of chinese hamster cells, synchronized by selecting for cells at or close to division, were exposed to 250 kvp x-rays and to ultraviolet light at different stages of the cell cycle and colony-forming ability examined thereafter. these cells were found to be most resistant to x-rays during the latter part of the dna synthetic period (s) and to be about equally sensitive before (g(1)) and after (g(2)) this period. multitarget type curves of the same slope (d(o) approximately 200 rad) o ...196514284327
dna replication patterns in somatic and germ-line cells of the male chinese hamster. 19655864053
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