Publications

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proceedings: the human loci for phosphopyruvate hydratase and guanylate kinase are syntenic with the pgd-pgm1 linkage group in man-chinese hamster somatic cell hybrids. 19744363865
chromosome assignment of the human gene for galactose-1-phosphate uridyltransferase.somatic cell hybrids formed between galactose-negative mutant chinese hamster cells and human lymphocytes were selected in galactose medium and analyzed for the concurrent presence of specific human chromosome(s) and human galactose-1-phosphate uridyltransferase. in one of the hybrid clones only a single human chromosome, a2, was consistently present when the hybrid cells were maintained in the selective medium, suggesting that the location of the structural gene for galactose-1-phosphate uridyl ...19744521812
genetics of somatic mammalian cells: biochemical genetics of chinese hamster cell mutants with deviant purine metabolism.studies are presented on the biochemical genetics of 30 adenine-requiring mutants of the chinese hamster ovary cell which were induced by mutagenesis and selected by the brdu-visible light technique. representative experiments conducted with these mutants include: hybridization with each other; hybridization with normal human cells; nutritional analysis; biochemical analysis with radioactively labeled intermediates; and measurement of reversion frequencies to wild-type phenotype occurring sponta ...19744525316
elongation of the polyadenylate segment of messenger rna in the cytoplasm of mammalian cells.chinese hamster and mouse sarcoma 180 ascites cells, treated with high levels of actinomycin d, still carry out limited poly(a) synthesis. the residual activity, which consists of poly(a) chain extension in the cytoplasm as well as in the nucleus, is essentially insensitive to cordycepin. nuclear polyadenylation proceeds linearly and involves the gradual extension of unusually long poly(a) sequences. cytoplasmic poly(a) labeling is initially more rapid than in the nucleus, but levels off within ...19744547843
proceedings: a modified technique for separating mouse and chinese hamster from human hprt and human and chinese hamster from mouse aprt. 19744827479
proceedings: evidence for synteny between the human loci for fumarate hydratase, udp glucose pyrophosphorylase, 6-phosphogluconate dehydrogenase, phosphoglucomutase1, and peptidase-c in man-chinese hamster somatic cell hybrids. 19744827484
abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetically diabetic chinese hamster.hereditary insulin-deficient diabetes mellitus occurs in certain sublines of nonobese chinese hamsters. several characteristics of this syndrome are similar to those seen in insulin-deficient human diabetics. therefore, to characterize pancreatic islet function, dynamic insulin and glucagon release from normal and nonketotic diabetic hamster pancreases in response to glucose (300 mg/100 ml) and theophylline (10 mm), infused singly and together, was studied in vitro.20-min glucose infusions of no ...19744830228
the influence of serum components on the growth and mutation of chinese hamster cells in medium containing aminopterin. 19744843973
nascent dna synthesis in ultraviolet light-irradiated mouse, human and chinese hamster cells.the technique of alkaline sucrose gradient centrifugation was used to study newly synthesized dna in control and ultraviolet light-irradiated mouse l, human hela, and chinese hamster ovary cells. nascent dna molecular weight distributions did not appear to differ among the three cell lines for unirradiated cells. however, at short times after ultraviolet light irradiation, human hela cells appeared to synthesize more low molecular weight dna than either mouse l or chinese hamster ovary cells. si ...19744856721
the effect of post-treatment with caffeine on survival and uv-induced mutation frequencies in chinese hamster and mouse lymphoma cells in vitro. 19744859533
studies in the diabetic chinese hamster: electron microscopy of pancreatic islets. 19744615024
effects of various cyclophosphamide concentrations in vivo on sister chromatid exchanges (sce) and chromosome aberrations of chinese hamster bone marrow cells: comparison of two methods measuring the mutagenicity of a test compound.the in vivo sce formation and the induction of chromosome aberrations in the bone marrow of chinese hamsters (cricetulus griseus) were studied after various concentrations of cyclophosphamide, and the sensitivity of the two test methods was compared. the administraiton of 1.0, 5.0, 13.3, 25.0, and 40.0 mg/kg body weight induced a dose-dependent increase in sce. the frequency of chromosome aberration, however, was not increased significantly with doses of 1.0 and 5.0 mg/kg body weight. only with ...1974429007
enhanced intestinal fat absorption in diabetic chinese hamsters. 19734773551
effect of 2450-mhz microwaves on the radiation response of x-irradiated chinese hamsters. 19734703889
evidence from triton x-100 polyacrylamide gel electrophoresis that histone f2a2, not f2b, is phosphorylated in chinese hamster cells. 19734796852
dna cross-linking in chinese hamster cells exposed to near ultraviolet light in the presence of 4,5',8-trimethylpsoralen. 19734798023
temporal organization of dna in chinese hamster cells: cell-cycle dependent association of dna with membrane. 19734798022
[mutagenic effect of o-methylhydroxylamine in chinese hamster cell cultures]. 19734807121
dna synthesis and mitosis in a temperature sensitive chinese hamster cell line. 19734798033
letter: damage and repair of dna in 5-bromodeoxyuridine-labeled chinese hamster cells exposed to fluorescent light. 19734796887
isolation and properties of a glucosamine-requiring mutant of chinese hamster lung cells. 19734788622
[synchronization of chinese hamster cell cultures with colcemid]. 19734781678
growth and radiation survival characteristics of v79-171b chinese hamster cells: a possible influence of intercellular contact. 19734767132
on the properties of a membrane-associated protein kinase from chinese hamster ovary cells. 19734356721
morphological transformation of enucleated chinese hamster ovary cells by dibutyryl adenosine 3',5'-monophosphate and hormones. 19734357169
the response of chinese hamster (ovary) cells to protracted irradiation from 252cf and 60co. 19734761145
derivation of tk- clones from revertant tk+ mammalian cells.in order to obtain a large collection of chinese hamster cell clones defective in thymidine kinase (tk(-)), brdu(r) selection experiments have been performed on wild-type and revertant tk(+) cell lines. no clones (< 10(-9)) were obtained from the wild-type tk(+) cell line by single-step selection. in contrast, revertant tk(+) clones readily gave rise to stable tk(-) derivatives (1 - 2 x 10(-4)). both wild-type and revertant tk(+) clones spontaneously yielded 8-ag(r) colonies with the same freque ...19734359755
enhancement by caffeine of n-methyl-n-nitrosourea-induced mutations and chromosome aberrations in chinese hamster cells. 19734356743
dna-degradation and excision repair in gamma-irradiated chinese hamster ovary cells. 19734518364
effect of neocarzinostatin on v-79 chinese hamster cells in vitro. 19734803216
inhibition of post-replication repair of alkylated dna by caffeine in chinese hamster cells but not hela cells. 19734796966
caffeine inhibition of postreplication repair of n-acetoxy-2-acetylamino fluorene-damaged dna in chinese hamster cells. 19734795392
the effect of ploidy on chemical mutagenesis in cultured chinese hamster cells. 19734753423
effect of streptozotocin in the chinese hamster (cricetulus griseus). 19734355607
subcellular distribution of aminoacyl-transfer rna synthetases in chinese hamster ovary cell culture. 19734796768
studies on 1-beta-d-arabinofuranosyl-cytosine-resistant mutants of chinese-hamster fibroblasts. a mitochondrial deoxycytidine kinase devoid of activity on arabino-cytosine. 19734359990
contrast between the environmental ph dependencies of prophasing and nuclear membrane formation in interphase-metaphase cells.in chinese hamster don cells, fusion of an interphase cell with a metaphase cell resulted either in prophasing of the interphase nucleus, including loss of the nuclear envelope (ne), or in the formation of a double membrane around the metaphase chromosomes. only one of these phenomena occurred in a given interphase-metaphase (i-m) binucleate cell. at ph 7.4, there was about an equal probability that either event could occur amongst the population of i-m cells. the effect of ph changes in the med ...19734795862
cyclic amp-amplified replication of rna tumour virus-like particles in chinese hamster ovary cells. 19734125454
synchronization of mitochondrial dna synthesis in chinese hamster cells (line cho) deprived of isoleucine.mitochondrial dna (mit-dna) synthesis was compared in suspension cultures of chinese hamster cells (line cho) whose cell cycle events had been synchronized by isoleucine deprivation or mitotic selection. at hourly intervals during cell cycle progression, synchronized cells were exposed to tritiated thymidine ([(3)h]tdr), homogenized, and nuclei and mitochondria isolated by differential centrifugation. mit-dna and nuclear dna were isolated and incorporation of radioisotope measured as counts per ...19734738104
further characterization of the f1-histone phosphokinase of metaphase-arrested animal cells.exponentially growing chinese hamster cells are found to contain two major phosphokinase activities with specificity for the phosphorylation of f1 (lysine-rich) histone. these two activities, designated ki and kii, were extracted with 0.35 m nacl and fractionated in 0.2 m nacl by sephadex g-200 gel filtration. ki, which is similar to the ubiquitous cyclic 3',5'-adenosine monophosphate (camp)-dependent phosphokinase, differs from kii by several criteria. kii is mol wt 90,000, camp independent, ra ...19734738102
repair of potentially lethal lesions in x-irradiated, density-inhibited chinese hamster cells: metabolic effects and hypoxia. 19734737348
banding patterns of chromosomes in bone marrow cells of the chinese hamster as revealed by acetic-saline-giemsa, urea, and trypsin technics. 19734126149
fucose-containing glycopeptides from the cell surface of chinese hamster ovary cells grown in the presence or absence of cyclic amp. 19734352890
similar growth of chinese hamster cells in the presence of phenethyl alcohol or dibutyryl cyclic amp. 19734352889
effect of puromycin on dna replication in chinese hamster cells. 19734269487
[dynamics of the ionic makeup and of the synthesis of rna and protein during the induction of proliferation in a chinese hamster resting cell culture]. 19734779386
fractionated ultraviolet light irradiation of cultured chinese hamster cells. 19734736801
replicon origins in chinese hamster cell dna. ii. reproducibility. 19734274005
specificity of compaction in meiotic chromosomes of the female chinese hamster. 19734730552
effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis in chinese hamster ovary cells. 19734736079
genetics of somatic mammalian cells. xvii. induction and isolation of chinese hamster cell mutants requiring serine. 19734736583
psoralen plus near ultraviolet light inactivation of cultured chinese hamster cells and its relation to dna cross-links. 19734736482
changes in surface morphology of chinese hamster ovary cells during the cell cycle.synchronized populations of chinese hamster ovary (cho) cells in confluent culture have been examined by scanning electron microscopy and their surface changes noted as the cells progress through the cycle. during g(1) it is characteristic for cells to show large numbers of microvilli, blebs, and ruffles. except for the ruffles, these tend to diminish in prominence during s and the cells become relatively smooth as they spread thinly over the substrate. during g(2) microvilli increase in number ...19734735453
x-ray-induced delay in the chinese hamster cell-cycle: dependence on phase irradiated under different culturing conditions, budr incorporation, and hypertonic treatment. 19734542039
methylation rapidly reannealing dna during the cell cycle of chinese hamster cells. 19734736387
inhibition of repair of uv-damaged dna by caffeine and mutation induction in chinese hamster cells. 19734736056
comparative studies on the carbohydrate-containing membrane components of normal and adenosine 3':5'-cyclic monophosphate-treated chinese hamster ovary cells.1. we investigated some of the changes in plasma-membrane composition that accompany the alteration in cell growth and morphology induced by treating chinese-hamster ovary cells with dibutyryladenosine 3':5'-cyclic monophosphate (dibutyryl cyclic amp). 2. a double-labelling technique was employed in which normal cells were given (14)c-labelled precursor, and those treated with dibutyryl cyclic amp were given (3)h label. l-leucine, d-glucosamine, and l-fucose were used to label the membranes. 3. ...19734353087
[changes in the cell cycle parameter of chinese hamster fibroblasts under chronic hypoxia, measured by impulse-cytophotometer]. 19734736095
f1-histone phosphorylation in metaphase chromosomes of cultured chinese hamster cells. 19734349566
the induction of azaguanine-resistant mutants in cultured chinese hamster cells by reactive derivatives of carcinogenic hydrocarbons. 19734793501
feulgen cytophotometric absorption measurements in prophase stages of meiosis in the male chinese hamster. 19734717737
effects of actinomycin d on spermatogenesis in the chinese hamster. 19734702797
morphology and growth rate changes in chinese hamster cells cultured in presence of sodium butyrate. 19734349017
conditionally lethal mutations in chinese hamster cells. i. isolation of a temperature-sensitive line and its investigation by cell cycle studies. 19734348554
replication of dna in mammalian chromosomes: isolation of replicating segments.from chinese hamster cells, blocked at the beginning of the s phase by treatment with fluorodeoxyuridine and pulse-labeled with [(3)h]thymidine, one can release segments of native dna containing template polyuncleotide chains and the most recently replicated dna. the segments, which can be released without shear by lysis at temperatures below the melting point for the double helix, can be separated from both the nascent single chains (okazaki pieces) and the long strands of native dna in sodium ...19734268701
interallelic complementation in hybrid cells derived from chinese hamster diploid clones deficient in hypoxanthine-guanine phosphoribosyl-transferase activity. 19734570359
phosphorylation of high-molecular-weight membrane protein species in chinese-hamster ovary cells in culture: effect of 6-n,2'-o-dibutyryladenosine 3':5'-cyclic monophosphate plus testosterone.growth of chinese-hamster ovary cells in [(32)p]phosphate and [(3)h]leucine and subsequent assay of the plasma membranes reveals phosphorylation in two protein regions corresponding to molecular weights of 280000 and 195000. culture in the presence of the 6-n,2-o'-dibutyryl derivative of cyclic amp plus testosterone does not stimulate [(32)p]-phosphate incorporation, but determines a modification in the qualitative pattern of phosphorylation.19734353384
evidence for pleiotropic changes in lines of chinese hamster ovary cells resistant to concanavalin a and phytohemagglutinin-p.lines of chinese hamster ovary cells resistant to the lectins concanavalin a (con a) and phytohemagglutinin-p (pha-p) have been isolated and characterized. lines were isolated by a stepwise, a single-step, or a cycling single-step procedure, from both mutagen-treated and untreated cultures. the resistant lines showed a higher efficiency of colony formation in the presence of the appropriate lectin than did the wild-type parental line. the cell lines resistant to con a did not exhibit any detecta ...19734347206
initiation and continuation of dna replication are not associated with the nuclear envelope in mammalian cells.for determination of whether dna replication is initiated at the nuclear envelope, synchronized chinese hamster ovary cells labeled with [(3)h]thymidine were examined by electron microscope radioautography. the cells were synchronized initially by mitotic shake-off and held at the g(1)-s border by 5-fluorodeoxyuridine plus amethopterin. cells were fixed at 1, 5, 10, and 30 min after the inhibitors were counteracted with [(3)h]thymidine. radioautographic silver grains in each case were present ov ...19734268475
radiation-induced cycle delay in synchronized chinese hamster cells: comparison between dna synthesis and division. 19734695230
cytotoxicity and mutagenicity of ultraviolet irradiation as a function of the interval between split doses in cultured chinese hamster cells. 19734684406
relative radiosensitivities of tetraploid and diploid chinese hamster cells in culture exposed to ionizing radiation. 19734684404
caffeine potentiation of the chromosome damage produced in bean root tips and in chinese hamster cells by various chemical and physical agents. 19734684403
cytogenetic and mutagenic effects of ddt and dde in a chinese hamster cell line. 19734346226
unscheduled dna synthesis and repair replication in uv-irradiated chinese-hamster cells. 19734122930
the effect of inhibitors of rna and protein synthesis on dibutyryl cyclic amp mediated morphological transformations of chinese hamster ovary cells in vitro. 19734347524
[expression of tumorigenic potential in isologous hybrid clones of chinese hamster cells (author's transl)]. 19734790834
photoreactivation of ultraviolet-induced chromosomal aberrations.ultraviolet induces only chromatid-type aberrations in synchronized g(1) v-79 chinese hamster and a8w243 xenopus tissue culture cells. posttreatment with white light prevents expression of most potential aberrations in the a8 toad cell, which possesses a photoreactivation enzyme. we conclude that the major ultraviolet-induced dna lesion leading to chromosomal aberrations is the pyrimidine dimer.19734682133
determination of the cell cycle by microautoradiographic method in the cells of bone marrow in the chinese hamster in vivo. 19734805256
caffeine, caffeine derivatives and chromosomal aberrations. vi. the influence of temperature on the aberration-frequency induced during prophase and late g2 by 8-methoxycaffeine and 8-chlorocaffeine in chinese hamster cells. 19734798690
cell membrane permeability during the cell generation cycle in chinese hamster ovary cells. 19734797788
structuredness of the cytoplasmic matrix and michaelis-menten constants for the hydrolysis of fda during the cell cycle in chinese hamster ovary cells. 19734797787
the development of the diencephalon in the chinese hamster: an investigation into the validity of the criteria of subdivision of the brain. 19734755748
a quantitative analysis of colcemid-induced chromosomal nondisjunction in chinese hamster cells in vitro. 19734714918
[topographic anatomy of the thoracic cavity and neck in the chinese dwarf hamster (cricetulus griseus milne edwards 1867)]. 19734707943
the effect of x-rays on labelling pattern of m 1 and m 2 chromosomes in chinese hamster cells. 19734682596
stable telocentric chromosomes produced by centric fission in chinese hamster cells in vitro. 19734682090
the chromosomes of cho, an aneuploid chinese hamster cell line: g-band, c-band, and autoradiographic analyses. 19734120885
cellular reactions of o6-methylguanine, a product of some alkylating carcinogens.cultures of a purine-requiring mutant of chinese hamster ovary cells (cho-104b), randomly bred hamster embryo cells, or escherichia coli b(s-1) were treated with non-toxic doses of (3)h-labelled o(6)-methylguanine. dna and rna were isolated and subjected to enzymic digestion to nucleosides at ph8. the products of digestion were analysed by ion-exchange chromatography on columns of dowex 50 (nh(4) (+) form) at ph8.9. no (3)h-labelled o(6)-methylguanosine was detected in nucleic acid digests. (3)h ...19734590203
nature of the iron requirement for chinese hamster v79 cells in tissue culture medium. 19734734766
relationship between the ratio of parental chromosomes and parental doubling times in chinese hamster-mouse somatic cell hybrids. 19734736587
surface antigens of mammalian cells as genetic markers. ii.a second surface antigen, b(l), lethal in the presence of specific antibody and complement has been identified on some human cells and shown to behave as a good genetic marker. it is autosomal, unlinked to the human a(l) antigen previously described, and unlinked to 15 other human genes. the a(l) antigen, which is linked to the lactic dehydrogenase a gene, is found on the hela, the cultured human fibroblast, and in small amounts on the human lymphocyte. b(l) occurs on hela cells, on cultured hum ...19734736830
independent loss of human hexosaminidases a and b in man-chinese hamster somatic cell hybrids. 19734737100
a cytological study of the karyotype of spleen cells from scrapie-affected chinese hamsters. 19734738622
caffeine inhibition of postreplication repair of n-acetoxy-2-acetylaminofluorene-damaged dna in chinese hamster cells. 19734741935
[the development of cell classes in the liver of rats and chinese hamsters (author's transl)]. 19734777261
comparative studies of organs in the european hamster (cricetus cricetus l.), the syrian golden hamster (mesocricetus auratus w.) and the chinese hamster (cricetulus griseus m.). 19734779674
cytological mapping of the genes assigned to the human a 1 chromosome by use of radiation-induced chromosome breakage in a human-chinese hamster hybrid cell line. 19734785162
cell-cycle-dependent variations of deoxyribonucleoside triphosphate pools in chinese hamster cells. 19734795783
effect of amino acid and serum deprivation on the regulation of rna synthesis in cultured chinese hamster ovary cells. 19734796172
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