TitleAbstractYear(sorted ascending)
antigenotoxic properties of paliurus spina-christi mill fruits and their active compounds.paliurus spina-christi mill. (ps) fruits are widely used for different medical purposes in turkey. like in many medicinal herbs the studies concerning their activity, the activities of ps are also not well clarified. the aim of this study is to evaluate the antigenotoxicity of the compounds isolated and identified from the extracts of ps fruits.028446228
arf6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation.we have shown previously that the adp-ribosylation factor (arf)-6 gtpase localizes to the plasma membrane and intracellular endosomal compartments. expression of arf6 mutants perturbs endosomal trafficking and the morphology of the peripheral membrane system. however, another study on the distribution of arf6 in subcellular fractions of chinese hamster ovary (cho) cells suggested that arf6 did not localize to endosomes labeled after 10 min of horseradish peroxidase (hrp) uptake, but instead was ...09456320
invertebrate specific d1-like dopamine receptor in control of salivary glands in the black-legged tick ixodes scapularis.the control of tick salivary secretion, which plays a crucial role in compromising the host immune system, involves complex neural mechanisms. dopamine is known to be the most potent activator of salivary secretion, as a paracrine/autocrine factor. we describe the invertebrate-specific d1-like dopamine receptor (invd1l), which is highly expressed in tick salivary glands. the invd1l phylogenic clade was found only in invertebrates, suggesting that this receptor was lost in vertebrates during evol ...024307522
catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase.alkylglycerol mono-oxygenase (ec forms a third, distinct, class among tetrahydrobiopterin-dependent enzymes in addition to aromatic amino acid hydroxylases and nitric oxide synthases. its protein sequence contains the fatty acid hydroxylase motif, a signature indicative of a di-iron centre, which contains eight conserved histidine residues. membrane enzymes containing this motif, including alkylglycerol mono-oxygenase, are especially labile and so far have not been purified to homogen ...022220568
mucopolysaccharidosis type i in 21 czech and slovak patients: mutation analysis suggests a functional importance of c-terminus of the idua protein.mucopolysaccharidosis type i (mps i) is an autosomal recessive lysosomal storage disorder that is caused by a deficiency of the enzyme alpha-l-iduronidase (idua). of the 21 czech and slovak patients who have been diagnosed with mps i in the last 30 years, 16 have a severe clinical presentation (hurler syndrome), 2 less severe manifestations (scheie syndrome), and 3 an intermediate severity (hurler/scheie phenotype). mutation analysis was performed in 20 mps i patients and 39 mutant alleles were ...019396826
etiology of oroya fever : xi. comparison of bartonella bacilliformis and bartonella muris. cultivation of bacterium murium, n. sp.bartonella muris appeared in the blood of all white rats, wild rats, chinese hamster, and mice, from which the spleen was removed, but did not appear in that of splenectomized monkeys, rabbits, or guinea pigs. it has not been possible to transmit b. muris to normal rats, monkeys, rabbits, or guinea pigs, by intraperitoneal, intradermal, or intravenous injection of blood containing b. muris from splenectomized rats. in two instances an acute orchitis was induced in normal rats by injection direct ...192819869409
synergism between halothane and nitrous oxide in the production of nuclear abnormalities in the dividing fibroblast.when chinese hamster fibroblasts divide in the presence of halothane there is an increased incidence of cells with abnormal nuclei, both in mitosis and in interphase. the authors compared the effects of halothane and nitrous oxide separately and in combination. nitrous oxide, 75 percent, alone had no significant effect compared with controls, less than 1.4 per cent of cells showing abnormalities, while halothane alone had a dose-dependent effect on both phases of the cell cycle. halothane, 1 per ...19511275313
the fate of leishmania donovani and leptomonas donovani injected into the peritoneal cavity of chinese hamsters and guinea-pigs. 195114905521
the use of the chinese hamsters (cricetulus griseus) in the study of mycobacterium tuberculosis. i. comparison between the cultural method and animal inoculation for the primary isolation of tubercle bacilli. 195114822071
the use of the chinese hamsters (cricetulus griseus) in the study of mycobacterium tuberculosis. ii. for the differentiation of human and bovine types. 195114831170
the cheek pouch of the chinese hamster (cricetulus griseus) for cinephotomicroscopy of blood circulation and tumor growth. 195413174931
adrenal lipid response in chinese hamsters infected with trichinella spiralis. 195713495461
the chinese hamster (cricetulus griseus) as an experimental host for trichinella spiralis. 195713476305
observations on the chromosomes of chinese hamster cells in tissue culture. 195813576097
the striped-back or chinese hamster, cricetulus griseus. 195813539619
genetics of somatic mammalian cells. ii. chromosomal constitution of cells in tissue culture.a convenient, reliable method for chromosome delineation of animal cells grown as monolayers on glass has been applied to human, opossum, and chinese hamster cells. tissue cultured cells from 5 different, normal organs of 7 different human subjects uniformly displayed the expected chromosome number of 46 and showed no variations in morphology or number other than the expected sex differences and a small incidence of polyploidy. the chromosomes of normal cells from the american opossum were as un ...195813563760
[comparative nuclear volumetric investigation in cricetus cricetus, cricetulus barabensis griseus & the presumably tetraploid mesocricetus auratus (gold hamster)]. 195813558423
further observations on the chromosomes of chinese hamster cells in tissue culture. 195913655062
spontaneous hereditary diabetes mellitus in chinese hamster (cricetulus griseus). 1. pathological findings. 195913645727
biochemical studies on the chinese hamster (22 chromosomes) and the syrian hamster (44 chromosomes). 195913653002
elevated alpha-2-serum proteins as a possible genetic marker in spontaneous hereditary diabetes mellitus of the chinese hamster (cricetulus griseus). 196013708201
radiation response of mammalian cells grown in culture. 1. repair of x-ray damage in surviving chinese hamster cells. 196013726391
asynchronous duplication of chromosomes in cultured cells of chinese hamster.chromosome duplication (dna synthesis) was studied in cultured cells of chinese hamsters by means of autoradiography following thymidine-h(3) incorporation. the technique used was to expose an asynchronously dividing population of rapidly growing cells for a 10 minute interval to a medium with thymidine-h(3). cells were then transferred to a medium with excess unlabeled thymidine. the population was sampled at intervals thereafter and studies made of the frequency of labeled interphases and divi ...196013837165
progressive intercapillary glomerulosclerosis in the mouse, rat, and chinese hamster, associated with aging and x-ray exposure. 196013830499
periodontal pathology in a strain of chinese hamster, cricetulus griseus, with hereditary diabetes mellitus. 196113880291
the evaluation of x-ray-induced chromosome aberrations in cell-cultures of the chinese hamster. 196113901497
spontaneous and x-ray-induced somatic-chromosome aberrations in the chinese hamster. 196113867089
the interaction of mammalian cells with antibodies. i.the single cell plating technique has been applied to quantitation of the reproductive killing of mammalian cells by specific antibodies. this method confirms previous demonstrations by other workers of localization of all the killing activity in the gamma-globulin fraction of specific cell antisera but not of normal sera; the need for complement for the killing action in low doses of antibody and the leakage of cell constituents attending cell killing under these conditions. in concentrations o ...196113730250
chinese-hamster cell strains in vitro:spontaneous chromosome changes and latent polyoma-virus infection. 196113700713
adenocarcinoma of the pancreas in diabetes-prone chinese hamsters. 196114487364
clonal growth of diploid chinese hamster cells in a synthetic medium supplemented with purified protein fractions. 196213952249
x-ray-induced chromosome aberrations in the corneal epithelium of the chinese hamster.when the corneal epithelium of the chinese hamster is irradiated with ionizing radiation in vivo, a rectilinear relationship is observed between the yield of chromosome aberrations and the dose of x-rays within a dose range of 10 to 150 r. there is no threshold effect for chromosome breakage down to the 10-r level. the mean breakage rate of 0.00352 breaks per cell per roentgen is in very close agreement with the data obtained on other mammalian tissues, both in vitro and in vivo.196217820998
acute x-ray lethality in the chinese hamster after whole-body and partial-body irradiation. 196214022952
radiosensitivity of cells of chinese hamster in vitro in relation to the cell cycle. 196213955320
relationship between large y-chromosome and side-by-side pairing of the xy-bivalent observed in the chinese hamster, cricetus griseus. 196214481405
the histogenesis of experimentally produced melanotic tumours in the chinese hamster (cricetulus criseus). 196314111612
variations in x-ray response during the division cycle of partially synchronized chinese hamster cells in culture. 196314072031
mammalian chromosomes in vitro: xvi. analysis of chromosomes breakages in cell population of the chinese hamster. 196314278852
observations of retinal microaneurysms in a metahypophyseal diabetic chinese hamster. 196314061601
dependence of frequency of x-ray-induced chromosome aberrations on dose rate in the chinese hamster. 196314060651
relative ultraviolet sensitivity of different phases in the cell cycle of chinese hamster cells grown in vitro. 196313955703
albumin replacement by fatty acids in clonal growth of mammalian cells.clonal growth of chinese hamster strain chd-3 cells in a synthetic nutrient mixture supplemented with 10 micrograms of purified fetuin per milliliter exhibits an apparent requirement for serum albumin. the albumin can be replaced by linoleic acid, which occurs as a tightly bound component of most albumin preparations. linolenic acid and corn oil can also replace albumin, while oleic acid and esters of linoleic and linolenic acids cannot.196313952251
[effects of sodium bromide and caffeine on the induction of pituitary adenomas by estrogen in chinese hamsters]. 196314089279
observation of retinopathy in metahypophyseal diabetic chinese hamsters. 196314090728
prediction of spontaneous hereditary diabetes mellitus in chinese hamsters by means of elevated alpha-2 serum levels. 196313950103
pulpal and periodontal disease in a strain of chinese hamsters with hereditary diabetes mellitus. 196314022075
gross and chromosomal cytology of virus infected chinese hamster cells. 196313934263
an improved nutrient solution for diploid chinese hamster and human cell lines. 196313952250
cellular alterations in the mch line of chinese hamster cells following infection with herpes simplex virus. 196313952430
chromosomes of x-ray-induced giant cells in chinese hamster in vitro. 196414254441
chromosomal variability in clonal populations of a chinese hamster cell strain. 196414241786
mammalian chromosomes in vitro. 18. dna replication in the chinese hamster.the complete dna replication sequence of the entire complement of chromosomes in the chinese hamster may be studied by using the method of continuous h(3)-thymidine labeling and the method of 5-fluorodeoxyuridine block with h(3)-thymidine pulse labeling as relief. many chromosomes start dna synthesis simultaneously at multiple sites, but the sex chromosomes (the y and the long arm of the x) begin dna replication approximately 4.5 hours later and are the last members of the complement to finish r ...196414228518
lysosomes in chinese hamster fibroblasts in culture. 196414208742
polyploidy induced by x-rays in chinese hamster cells in vitro.the incidence of polyploidy (specifically, in this case, the doubling of the stemline chromosome number) induced by x-rays in cells cultured in vitro is about the same for both "near-diploid" and "near-tetraploid" sublines of the chinese hamster. endoreduplication is a principal cytological mechanism for this form of induced polyploidy.196414163776
recovery following x-irradiation of synchronized chinese hamster cells. 196414201754
restitution of radiation-induced chromosomal damage in chinese hamster cells related to the cell's life cycle. 196414195435
the frequency of sister chromatid exchanges following exposure to varying doses of h3-thymidine or the chinese hamster cell line chef-125, sister chromatid exchanges occurred at a rate of a little higher than one per three chromosomes for each cell cycle. the exchanges were detectable by labeling with h(3)-thymidine and autoradiographic analyses of chromosomes at the second and subsequent metaphases after labeling had occurred. to test the hypothesis that sister chromatid exchanges are caused by radiation, cells were incubated in media with different amounts of h(3)-thymidine. no statistic ...196414153478
mammalian chromosomes in vitro. xvii. idiogram of the chinese hamster.from 67 diploid male chinese hamster cells in vitro, an idiogram was constructed. the chromosomes can be classified into 4 natural groups: group i, 2 pairs of large submetacentrics (1 and 2); group ii, 3 pairs of medium-sized submetacentrics (the sex pair, 4 and 5); group iii, 3 pairs of medium-sized subtelocentrics (6,7, and 8); group iv, 3 pairs of small metacentrics (9,10, and 11). a system of subdividing each chromosome into regions is also suggested.196419291904
life span, tumor incidence, and intercapillary glomerulosclerosis in the chinese hamster (cricetulus griseus) after whole-body and partial-body exposure to x-rays. 196414142190
homogeneity and stability of chromosomes of chinese hamster cells in vitro. 196414165061
life cycle analysis of mammalian cells. ii. cells from the chinese hamster ovary grown in suspension culture.a method for life cycle analysis in mammalian cells which utilizes the collection function has been applied to the chinese hamster ovary grown in suspension. the following durations were found for the various parts of the life cycle: s, 4.13 hours; g1, 4.71 hours; g2, 2.81 hours; mitosis, 0.81 hours. the cell has a total generation time of 12.4 hours as opposed to 20.1 hours for the s3 hela cell. however, the relative lengths of each phase of the life cycle are identical within experimental unce ...196414232130
a technique for studying the in situ. karyotype of epithelial cells from the cheek pouch of the chinese hamster. 196414161572
rous sarcoma in chinese hamsters.a variant of the rous sarcoma virus induced tumors in newborn chinese hamsters within 2 to8 weeks. the tumors grew progressively and sometimes metastasized. they were successfully transplanted in series in syrian hamsters. the chromosomes of the tumors in the chinese hamstersas well as of those transplanted into the syrian hamsters were chinese hamster chromosomes. virus was demonstrated in the chinese hamster tumors by injecting material from the tumors into chickens, where rous sarcomas subseq ...196414150329
infection of mch chinese hamster cells with herpes simplex virus: relation of cell killing to time of division. 196414240415
replication of mengovirus in chinese hamster ovary cells. la-3132-ms. 196414271615
hypoxic cell sensitizers and heavy charged-particle radiations.stationary-phase populations of chinese hamster v-79 cells were irradiated with 250 kv x-rays and the bragg peaks (spread to a width of 4 cm) of energetic he-, c-, ne-, and a-ion beams produced at the 184-inch cyclotron and bevalac at lawrence berkeley laboratory. survival curves were generated with each radiation for cells suspended in air-saturated and nitrogen-saturated medium with and without sensitizer present. the oxygen enhancement ratios (oers) measured for x-rays with 1mm metronidazole ...1964277223
synchronization of chinese hamster cells by reversal of colcemid inhibition. 19655325429
observations on the breeding and care of the chinese hamster, cricetulus griseus. 196514278298
some observations on nuclear budding and nuclear extrusions in a chinese hamster cell culture. 196514287282
x-ray and ultraviolet sensitivity of synchronized chinese hamster cells at various stages of the cell cycle.populations of chinese hamster cells, synchronized by selecting for cells at or close to division, were exposed to 250 kvp x-rays and to ultraviolet light at different stages of the cell cycle and colony-forming ability examined thereafter. these cells were found to be most resistant to x-rays during the latter part of the dna synthetic period (s) and to be about equally sensitive before (g(1)) and after (g(2)) this period. multitarget type curves of the same slope (d(o) approximately 200 rad) o ...196514284327
dna replication patterns in somatic and germ-line cells of the male chinese hamster. 19655864053
the nucleoli in mitotic divisions of mammalian cells in a number of mammalian cell strains nucleoli persisted through mitosis. this phenomenon was especially pronounced in several cell lines derived from chinese hamster tissues. all the methods employed, including radioautography with tritiated uridine, cytochemical stains (methyl green-pyronin and azure b), fluorescent microscopy (coriphosphine o), ribonuclease digestion, and electron microscopy, demonstrated that the bodies identified as persistent nucleoli in the mitotic stages had the same cha ...19654222282
persistent herpes simplex virus infection in vitro with cycles of cell destruction and regrowth.hampar, berge (national institute of dental research, bethesda, md.), and mary lou copeland. persistent herpes simplex virus infection in vitro with cycles of cell destruction and regrowth. j. bacteriol. 90:205-212. 1965.-the susceptibility of two chinese hamster cell lines to herpes simplex virus (hsv) was studied from the time of their initiation through successive subcultures. the cells' susceptibility to the cytocidal effects of hsv decreased as the number of cell passages increased. during ...196516562018
the effects of micro-operations on the morphology, survival, and lysosomes of chinese hamster fibroblasts. 196514329382
quantitative tritium autoradiography of mammalian chromosomes. i. the basic method.a technique has been developed that allows repeated autoradiographs to be made of the isotope distribution in the chromosomes of a single cell. a series of 10 separate autoradiographs were made of a chinese hamster diploid male metaphase cell which had been labeled with tritiated thymidine during the first 15 minutes of its dna synthesis period in the previous interphase. each autoradiograph had low grain densities above the chromosomes so that quantitation was feasible. the separate autoradiogr ...19655840794
the fine structure of the nucleolus in mitotic divisions of chinese hamster cells in vitro.the nucleolus of chinese hamster tissue culture cells (strain dede) was studied in each stage of mitosis with the electron microscope. mitotic cells were selectively removed from the cultures with 0.2 per cent trypsin and fixed in either osmium tetroxide or glutaraldehyde followed by osmium tetroxide. the cells were embedded in both prepolymerized methacrylate and epon 812. thin sections of interphase nucleoli revealed two consistent components; dense 150-a granules and fine fibrils which measur ...19655884631
mengovirus replication. 3. virus reproduction in chinese hamster ovary cells. 19654283990
mengovirus replication. iv. inhibition of chinese hamster ovary cell division as a result of infection with mengovirus. 19654283992
electronic separation of biological cells by volume.a device capable of separating biological cells (suspended in a conducting medium) according to volume has been developed. cell volume is measured in a coulter aperture, and the cells are subsequently isolated in droplets of the medium which are charged according to the sensed volume. the charged droplets then enter an electrostatic field and are deflected into a collection vessel. mixtures of mouse and human erythrocytes and a large volume component of mouse lymphoma cells were separated succes ...19655891056
production and characterization of multiple-layered populations of animal cells.dense populations containing 129 x 10(6) jensen sarcoma, 134 x 10(6) don chinese hamster, 28.9 x 10(6) wi-38 human diploid, 61.8 x 10(6) hep-2 human carcinoma, and 67.4 x 10(6) wish human amnion cells were produced from dilute inocula, 0.85 to 5.33 x 10(6), in 7 to 8 days in a perfusion system using replicate t-60 flasks. perfusion rates as high as 560 ml medium/day/t-60 were required to maintain ph (to ca +/-0.1 unit) and adequate nutrient supplies. the cell densities encountered are described ...19655884626
[inhibiting effect of mitoxantrone on cell cycle progression of chinese hamster ovary cells].the effect of mitoxantrone, a potential anticancer chemotherapeutic agent, on the cell cycle progression of chinese hamster ovary (cho) cells was investigated by microspectrophotometry. cho cells incubated with the agent for either 30 min or 24 h were inhibited, to various degrees, from proliferation. the inhibition appeared in dose dependent fashion. a 10-fold dose of the drug was required for the 30 min group, as compared to the 24h group, to develop an equivalent inhibiting effect. when expon ...19652094638
viruses and mammalian chromosomes. iv. replication of herpes simplex virus in diploid chinese hamster cells. 196514328610
radiosensitization of x chromosome of chinese hamster cells related to incorporation of 5-bromodeoxyuridine.selective incorporation of 5-bromodeoxyuridine into the late replicating arm of the x chromosome of chinese hamister cells cultured in vitro caused a selective radiosensization of the arm to ionizing radiation. radiation damage was observed as chromosomal aberrations, and incorporation was studied by using tritiated 5-bromodeoxyuridine.19665910191
x-ray sensitivity during the cell generation cycle of cultured chinese hamster cells. 19665924188
induction of thymine dimers in synchronized populations of chinese hamster cells. 19665970129
hyperinsulinemia with diabetes induced by cortisone, and the influence of growth hormone in the chinese hamster. 19665957189
cilia formation in chinese hamster fibroblasts in vitro as a response to colcemid treatment. 19665971010
life cycle analysis of mammalian cells. 3. the inhibition of division in chinese hamster cells by puromycin and actinomycin.analysis of the effects of actinomycin and puromycin on the g(2) and mitotic parts of the life cycle in chinese hamster ovary cells grown in suspension and synchronized by thymidine treatment has been carried out. rates of division of partially synchronized cell populations were measured in the presence and absence of the drugs, and various controls were performed to test for absence of complex side effects. actinomycin produces a block 1.9 hr before completion of division, while puromycin produ ...19665970563
regeneration of sialic acid on the surface of chinese hamster cells in culture. i. general characteristics of the replacement process. 19665967192
the kinetics of chromatid aberrations induced in chinese hamster cells by tritium-labeled thymidine. 19665920291
incorporation of [3-h]uridine and [m3-14-c]methionine into chinese-hamster cell ribonucleic acid. 19666006991
deoxyribonucleic acid replication of somatic cells in the chinese hamster. 19665914915
chronology of nucleic acid synthesis in meiosis of the male chinese hamster. 19665950863
cell cycle kinetics and radiation-induced chromosomal aberrations studied with c14 and h3 labels.chinese hamster cells in vitro were double labeled with c(14)tdr and h(3)tdr. at the time of irradiation with co(60) gamma rays (600 rad), the cells in the g(2) phase were labeled only with c(14), whereas cells in the late and middle s phases were labeled with both c(14) and h(3). the cells in early s phase were labeled only with h(3) and the g(1) cells were unlabeled. samples were fixed at various time intervals following irradiation and the metaphases were analyzed for chromosomal damage. the ...19665963459
metaphase arrest of chinese hamster cells with rotenone. 19665941244
hemogram of the chinese hamster. 19665959413
autoradiography of chromosomal dna fibers from chinese hamster cells. 19665221245
late-replicating chromosomal segments in aneuploid chinese hamster cell lines as determined by autoradiography. 19665909106
serum concentration: effects on cycle and x-ray sensitivity of mammalian cells.if the content of serum in the culture medium of exponentially growing chinese hamster cells is below optimum (15 percent), the doubling time and the resistance to x-irradiation of the cells are increased. in synchronously dividing populations the increase in doubling time is primarily caused by increase in duration of the postmitotic (g(1)) phase of the cells; this phase is relatively radiation resistant. the response of the cells growing synchronously is related quantitatively to the response ...19665902390
on the homology between the x and the y chromosomes of the chinese hamster. 19666004688
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