Publications

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the induction of 8-azaguanine-resistant mutants in cultured chinese hamster cells by ultraviolet light. the effect of changes in post-irradiation conditions. 19725062850
[cytophotometric studies on the kinetics of feulgen's hydrolysis of metaphase chromosomes and spermatozoa in the spermatogenesis of the chinese hamster]. 19725050907
radiation-induced chromosome abberations in chinese hamster leukocytes. a comparison of in vivo and in vitro exposures. 19724537717
immune cytolysis and x irradiation: independent lethal action in chinese hamster cells in vitro. 19725062045
[distribution of 5-bromodeoxyuridine-induced chromosome aberrations along chinese hamster chromosomes]. 19725020132
induced changes in the rates of uridine- 3 h uptake and incorporation during the g 1 and s periods of synchronized chinese hamster cells.the rates of uridine-5-(3)h incorporation into rna and the rates of uridine uptake into the acid-soluble pool during the cell cycle of v79 chinese hamster cells were examined. cells cultured on eagle's minimal essential medium supplemented with fetal calf serum, lactalbumin hydrolysate, glutamine, and trypsin displayed rates of incorporation and uptake which increased only slightly during g(1) and accelerated sharply as dna synthesis commenced. in contrast, cells cultured on minimal essential me ...19725009516
survival response of asynchronous and synchronous chinese hamster cells exposed to fluorescent light following 5-bromodeoxyuridine incorporation. 19725062702
[autoradiographic analysis of chromosome localization in interphase nuclei of cricetulus griseus and vicia faba]. 19725062399
[spiralization of chinese hamster chromosomes after 5-bromodeoxyuridine treatment of cells in 2 consecutive mitotic cycles]. 19725062395
[transformation in vitro of a new cell line from the chinese hamster embryo (c.h.e.): evolution of the transplantability, the karyotype and the cell surface]. 19724622417
lymphocyte cultures from chinese hamster (cricetulus griseus). 19724111089
recovery and repair in chinese hamster cells following uv-irradiation. 19725066419
[topography of the peritoneal organs of the chinese minihamster (cricetulus griseus milne edwards 1867)]. 19725063830
cell cycle compartment analysis of chinese hamster cells in stationary phase cultures. 19725062785
studies on the structure of metaphase and interphase chromatin of chinese hamster cells by circular dichroism and thermal denaturation. 19724632121
occurrence and properties of a chromatin-associated f1-histone phosphokinase in mitotic chinese hamster cells. 19724347703
on the selection for the modal chromosome number in chinese hamster cells. 19724675123
polyploidy induced by x-rays during the cell cycle of chinese hamster cells in vitro. 19724674993
the effects of 144 ce- 144 pr on the metaphase chromosomes of the chinese hamster liver cells in vivo. 19724646441
alteration of nucleoside transport of chinese hamster cells by dibutyryl adenosine 3':5'-cyclic monophosphate.cultured chinese hamster ovary cells showed no significant change in generation time or fraction in the s-phase in the presence of 1 mm n(6),o(2')-dibutyryl adenosine 3':5'-cyclic monophosphate. growth continued for at least two generations after expression of the morphological transformation induced by this cyclic amp analog. despite identical growth rates, apparent rates of dna and rna synthesis (incorporation of [(3)h]-thymidine or [(3)h]uridine) were reduced up to 15-fold in log phase by 1 m ...19724345504
changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous chinese hamster cells. 19724674589
enhancement of x-ray damage in synchronous chinese hamster cells by hypertonic treatments. 19724674588
repair of sublethal and potentially lethal x-ray damage in synchronous chinese hamster cells. 19724674587
growth dynamics of mitochondria in synchronized chinese hamster cells.the increase in cell volume (from electronic cell sizing) and the apportionment of this volume amongst the nuclear, cytoplasmic, and mitochondrial subcellular compartments (from electron microscopy) were studied throughout the cell division cycle in partially synchronized cultures of chinese hamster v79-s171 cells. average whole cell volume was found to increase smoothly, consistent with the doubling in one generation of individual cell volume. nuclear size increased in like fashion. mean total ...19724674506
reversible arrest of chinese hamster cells in g1 by partial deprivation of leucine. 19724673827
mammalian cells with altered forms of rna polymerase ii.mutants of chinese hamster ovary cells that are resistant to alpha-amanitin can be isolated. at least some of these mutants contain an altered form of dna-dependent rna polymerase ii, as indicated by its resistance to alpha-amanitin. these results indicate that mutation to alpha-amanitin resistance involves a change of a structural gene.19724508306
the in vivo cytogenetic effects of 252 cf on liver and bone marrow of the chinese hamster. 19725084001
the retention, distribution, dose and cytogenetic effects of 241 amacitrate in the chinese hamster. 19725083994
damage and repair of dna in 5-bromodeoxyuridine-labeled chinese hamster cells exposed to fluorescent light.illumination of chinese hamster cells with fluorescent light after 5-bromodeoxyuridine incorporation leads to extensive single-strand breakage in the dna of the exposed cells. the rate of production of single-strand breaks is dependent on the extent to which thymine is replaced by 5-bromouracil. at least some of the breaks observed with alkaline gradients are probably produced in vivo and are probably not contingent upon alkaline hydrolysis since breakage can be demonstrated with neutral gradien ...19725063839
streptozotocin-diabetes in the chinese hamster. blood glucose and structural changes during the first 24 hours. 19724120450
the influence of lichen extracts on vicia faba and chinese hamster cells. 19724673674
expression of galactose genes in mammalian cells. i. galactose enzymes in chinese hamster ovary cell hybrids. 19725065777
effects of deprivation of two essential amino acids on dna synthesis in chinese hamster cells. 19724673146
survival curves and age response functions for chinese hamster cells exposed to x-rays or high let alpha-particles. 19724672846
actinomycin d inhibition of repair of a dna complex from chinese hamster cells. 19724541782
8-azaguanine resistance in mammalian cells. i. hypoxanthine-guanine phosphoribosyltransferase.chinese hamster cells were treated with ethyl methanesulfonate or n-methyl-n'-nitro-n-nitrosoguanidine, and mutants resistant to 8-azaguanine were selected and characterized. hypoxanthine-guanine phosphoribosyltransferase activity of sixteen mutants is extremely negative, making them suitable for reversion to hgprtase(+). ten of the extremely negative mutants revert at a frequency higher than 10(-7) suggesting their point mutational character. the remaining mutants have demonstrable hgprtase act ...19724345996
opposite effects of dibutyryl adenosine 3':5' cyclic monophosphate and serum on growth of chinese hamster cells. 19724344775
a practical method for production breeding of chinese hamsters (cricetulus griseus). 19724343330
banding patterns of chinese hamster chromosomes. 19724119150
regulation of glutamine synthetase in cultured chinese hamster cells. induction and repression by glutamine. 19724403489
biological damage from intranuclear tritium: dna strand breaks and their repair.isotopic decay in tritiated thymidine in the dna of frozen (-196 degrees c) chinese hamster cells causes breaks in dna strands to accumulate at a rate of 2.1 breaks per decay. after dna is thawed the tritium-induced breaks repair rapidly with a half-time of 15 minutes at 37 degrees c. in comparison to breakage by x-rays, the efficiency of dna strand breakage by tritium is equivalent to 0.48 rad per decay. this dose per decay is close to that predicted by simple dosimetric considerations (0.38 ra ...19725055946
tumorigenicity and agglutination by concanavalin a of chinese hamster cells and their hybrids. 19724661093
radiation mortality in the chinese hamster, cricetulus griseus, in relation to age. 19725056748
mutagenesis in cultured mammalian cells. ii. induction of gene mutations in chinese hamster cells. 19725053588
a method for comparing effects of different synchronizing protocols on mammalian cell cycle traverse. the traverse perturbation index.after treatment of chinese hamster cells (line cho) with various protocols for synchrony induction, the subsequent ability of cells to traverse the cell cycle (i e., to perform, an essential cell cycle process) has been determined by measurement of the dna distribution pattern among cells in large populations with the los alamos flow microfluorometer in the cultures prepared by the various synchronizing techniques the vast majority of cells traversed the cell cycle in a normal fashion; however, ...19725044762
replicon origins in chinese hamsters cell dna. i. labeling procedure and preliminary observations. 19724263528
[malignant cellular transformation and karyologic modifications: the contribution of intraspecific somatic hybridization in chinese hamsters]. 19724676768
in vitro leucocyte cultures of syrian and chinese hamsters. 19725064119
nature of the iron requirement for chinese hamster v79 cells in tissue culture medium. 19734734766
relationship between the ratio of parental chromosomes and parental doubling times in chinese hamster-mouse somatic cell hybrids. 19734736587
surface antigens of mammalian cells as genetic markers. ii.a second surface antigen, b(l), lethal in the presence of specific antibody and complement has been identified on some human cells and shown to behave as a good genetic marker. it is autosomal, unlinked to the human a(l) antigen previously described, and unlinked to 15 other human genes. the a(l) antigen, which is linked to the lactic dehydrogenase a gene, is found on the hela, the cultured human fibroblast, and in small amounts on the human lymphocyte. b(l) occurs on hela cells, on cultured hum ...19734736830
independent loss of human hexosaminidases a and b in man-chinese hamster somatic cell hybrids. 19734737100
a cytological study of the karyotype of spleen cells from scrapie-affected chinese hamsters. 19734738622
cellular reactions of o6-methylguanine, a product of some alkylating carcinogens.cultures of a purine-requiring mutant of chinese hamster ovary cells (cho-104b), randomly bred hamster embryo cells, or escherichia coli b(s-1) were treated with non-toxic doses of (3)h-labelled o(6)-methylguanine. dna and rna were isolated and subjected to enzymic digestion to nucleosides at ph8. the products of digestion were analysed by ion-exchange chromatography on columns of dowex 50 (nh(4) (+) form) at ph8.9. no (3)h-labelled o(6)-methylguanosine was detected in nucleic acid digests. (3)h ...19734590203
cytological mapping of the genes assigned to the human a 1 chromosome by use of radiation-induced chromosome breakage in a human-chinese hamster hybrid cell line. 19734785162
cell-cycle-dependent variations of deoxyribonucleoside triphosphate pools in chinese hamster cells. 19734795783
effect of amino acid and serum deprivation on the regulation of rna synthesis in cultured chinese hamster ovary cells. 19734796172
a comparison of the interaction of chinese hamster fibroblasts with human and bovine transferrins, and conalbumin (chick-egg transferrin). 19734796207
asparagine-requiring tumor cell lines and their non-requiring variants: cytogenetics, biochemistry and population dynamics.asparagine-requiring jensen and walker rat tumor cells and their asparagine-independent variants have been analyzed. the following results were obtained: (1) both cell lines have very low levels of asparagine synthetase, and non-requiring revertants isolated from these lines have elevated levels of the enzyme. (2) no differences in chromosome number were detected between the parent jensen line and five jensen non-requiring revertants isolated from it. (3) both jensen and walker cells undergo asp ...19734798091
chromosomal interchanges induced by radiation in spermatogonial cells and leukocytes of mouse and chinese hamster. 19734515916
regional localization of loci for human pgm and 6pgd on human chromosome one by use of hybrids of chinese hamster-human somatic cells.the human gene loci phosphoglucomutase(1) (pgm(1), ec 2.7.5.1) and 6-phosphogluconate dehydrogenase (6pgd, ec 1.1.1.43), which are located on human chromosome one, have been assigned to a specific region of the short arm of that chromosome, by use of a hybrid cell line derived from a chinese hamster cell line deficient in hypoxanthine phosphoribosyl transferase and a strain of human diploid fibroblasts. cytogenetic analysis of a hybrid clone maintained for about 50 generations in vitro revealed ...19734517931
expression of endogenous rna c-type virus group-specific antigens in mammalian cells.highly sensitive and specific radioimmunoassays are described for quantitation of the intraspecies determinants of several mammalian c-type viral group-specific (gs) antigens. an interspecies (gs-3) immunoassay has been developed which has both the broad reactivity and great sensitivity necessary for detection of c-type viruses where intraspecies gs assays are not available. by using these immunoassays, the expression of endogenous virus-specified gs antigens in mammalian cells of different spec ...19734127032
chromosome and chromatid exchanges in chinese hamster cells. 19734348023
the heterogeneous distribution of acid hydrolases within a homogeneous population of cultured mammalian cells.1. chinese-hamster ovary fibroblasts were cultured to provide a homogeneous cell population. homogenates obtained from these cells were fractionated by centrifugation techniques and the resulting fractions were analysed for protein and for enzymes representative of certain subcellular particles. 2. unlike those in rat liver homogenates, the mitochondrial and lysosomal populations proved impossible to separate by differential centrifugation owing to the similarity of their sedimentation propertie ...19734353380
expression of malignancy in interspecies chinese hamster x mouse cell hybrids. 19734355218
proline biosynthesis: multiple defects in chinese hamster ovary cells. 19734356052
microbial flora and viral contact status of chinese hamsters (cricetulus griseus). 19734357853
localization of genes on human chromosomes by studies of human-chinese hamster somatic cell hybrids. assignment of pgm3 to chromosome c6 and regional mapping of the pgd, pgm1 and pep-c genes on chromosome a1. 19734358963
a temperature-sensitive function in a chinese hamster line affecting dna synthesis. 19734359532
[the development of cell classes in the liver of rats and chinese hamsters (author's transl)]. 19734777261
mutations affecting the structure of hypoxanthine: guanine phosphoribosyltransferase in cultured chinese hamster cells.14 clones resistant to 8-azaguanine, isolated from mutagenically treated cultured cells from chinese hamsters, were tested for loss of enzymic and immunological activities of hypoxanthine: guanine phosphoribosyltransferase. three of the clones had no enzymic activity but reacted strongly with antiserum prepared against the enzyme (crm(+)), indicating the presence of a defective enzyme protein, probably caused by a mutation in its structural gene. the other 11 mutants had little or no enzymic or ...19734119786
caffeine inhibition of postreplication repair of n-acetoxy-2-acetylaminofluorene-damaged dna in chinese hamster cells. 19734741935
comparative studies of organs in the european hamster (cricetus cricetus l.), the syrian golden hamster (mesocricetus auratus w.) and the chinese hamster (cricetulus griseus m.). 19734779674
transfer of genetic information by purified metaphase chromosomes.transfer of genetic information from isolated mammalian chromosomes to recipient cells has been demonstrated. metaphase chromosomes isolated from chinese hamster fibroblasts were incubated with mouse a(9) cells containing a mutation at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus. cells were plated in a selective medium, resulting in death of all unaltered parental a(9) cells. however, colonies of cells containing hypoxanthine phosphoribosyl transferase (ec 2.4.2.8) appeared ...19734515624
identification of chick chromosomes in cell hybrids formed between chick erythrocytes and adenine-requiring mutants of chinese hamster cells.when chick erythrocytes were fused with adenine-requiring mutants of chinese hamster cells of two different complementation classes and grown in adenine-free medium for 1 week or longer, mitotic cells were observed containing both chick and chinese hamster metaphase chromosomes within a single cell. stable hybrid clones were subsequently isolated that possessed, in addition to a complete chinese hamster genome, a single specific chick chromosome. hybrids resulting from fusions involving differen ...19734517942
[characterization of a hybrid cell line, "human leukemia-chinese hamster"]. 19734364713
mutagenicity and carcinogenicity of n-methyl-n'-nitro-n-nitrosoguanidine i. induction of chromosome aberrations and mitotic anomalies in chinese hamster ovary cells.cultured chinese hamster ovary (cho) cells were exposed to different concentrations of n-methyl-n'-nitro-n-nitrosoguanidine (mnng) for either 24 hr or 6 days. for cytological consequences of mnng exposure, cho cells were treated for 24 hr and allowed a 24 hr recovery period prior to analysis; for the estimation of cytotoxicity of mnng, cells were treated for 6 days followed by a 6 day recovery period. the cytotoxic effect of mnng based on the colony-forming ability of treated cells showed a semi ...1973422929
isolation and characterization of revertants of the mammalian temperature sensitive leucyl-trna synthetase mutant tshl.nine spontaneous and seven ethyl methanesulfonate induced revertants of the chinese hamster ovary cell line mutant (tshl), which possesses a temperature sensitive leucyl-trna synthetase, were isolated and characterized with respect to growth rate, leucyl-trna synthetase activity and thermolability, intracellular leucine pool size, and rrna content. although most revertants had increased leucyl-trna synthetase activity, and of those tested, all but one had increased thermostability, each appears ...1973422661
enhanced intestinal fat absorption in diabetic chinese hamsters. 19734773551
effect of 2450-mhz microwaves on the radiation response of x-irradiated chinese hamsters. 19734703889
enhancement by caffeine of n-methyl-n-nitrosourea-induced mutations and chromosome aberrations in chinese hamster cells. 19734356743
dna-degradation and excision repair in gamma-irradiated chinese hamster ovary cells. 19734518364
effect of neocarzinostatin on v-79 chinese hamster cells in vitro. 19734803216
inhibition of post-replication repair of alkylated dna by caffeine in chinese hamster cells but not hela cells. 19734796966
caffeine inhibition of postreplication repair of n-acetoxy-2-acetylamino fluorene-damaged dna in chinese hamster cells. 19734795392
the effect of ploidy on chemical mutagenesis in cultured chinese hamster cells. 19734753423
effect of streptozotocin in the chinese hamster (cricetulus griseus). 19734355607
subcellular distribution of aminoacyl-transfer rna synthetases in chinese hamster ovary cell culture. 19734796768
studies on 1-beta-d-arabinofuranosyl-cytosine-resistant mutants of chinese-hamster fibroblasts. a mitochondrial deoxycytidine kinase devoid of activity on arabino-cytosine. 19734359990
contrast between the environmental ph dependencies of prophasing and nuclear membrane formation in interphase-metaphase cells.in chinese hamster don cells, fusion of an interphase cell with a metaphase cell resulted either in prophasing of the interphase nucleus, including loss of the nuclear envelope (ne), or in the formation of a double membrane around the metaphase chromosomes. only one of these phenomena occurred in a given interphase-metaphase (i-m) binucleate cell. at ph 7.4, there was about an equal probability that either event could occur amongst the population of i-m cells. the effect of ph changes in the med ...19734795862
cyclic amp-amplified replication of rna tumour virus-like particles in chinese hamster ovary cells. 19734125454
synchronization of mitochondrial dna synthesis in chinese hamster cells (line cho) deprived of isoleucine.mitochondrial dna (mit-dna) synthesis was compared in suspension cultures of chinese hamster cells (line cho) whose cell cycle events had been synchronized by isoleucine deprivation or mitotic selection. at hourly intervals during cell cycle progression, synchronized cells were exposed to tritiated thymidine ([(3)h]tdr), homogenized, and nuclei and mitochondria isolated by differential centrifugation. mit-dna and nuclear dna were isolated and incorporation of radioisotope measured as counts per ...19734738104
further characterization of the f1-histone phosphokinase of metaphase-arrested animal cells.exponentially growing chinese hamster cells are found to contain two major phosphokinase activities with specificity for the phosphorylation of f1 (lysine-rich) histone. these two activities, designated ki and kii, were extracted with 0.35 m nacl and fractionated in 0.2 m nacl by sephadex g-200 gel filtration. ki, which is similar to the ubiquitous cyclic 3',5'-adenosine monophosphate (camp)-dependent phosphokinase, differs from kii by several criteria. kii is mol wt 90,000, camp independent, ra ...19734738102
repair of potentially lethal lesions in x-irradiated, density-inhibited chinese hamster cells: metabolic effects and hypoxia. 19734737348
banding patterns of chromosomes in bone marrow cells of the chinese hamster as revealed by acetic-saline-giemsa, urea, and trypsin technics. 19734126149
fucose-containing glycopeptides from the cell surface of chinese hamster ovary cells grown in the presence or absence of cyclic amp. 19734352890
similar growth of chinese hamster cells in the presence of phenethyl alcohol or dibutyryl cyclic amp. 19734352889
effect of puromycin on dna replication in chinese hamster cells. 19734269487
[dynamics of the ionic makeup and of the synthesis of rna and protein during the induction of proliferation in a chinese hamster resting cell culture]. 19734779386
fractionated ultraviolet light irradiation of cultured chinese hamster cells. 19734736801
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