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the influence of anaesthetics on the haematology of the patas monkey, erythrocebus patas.the effects of phencyclidine, ketamine and an alphaxalone-alphadolone mixture on the haematology of the patas monkeys have been compared. in animals sedated with phencyclidine or ketamine the only significant difference detected was in the mean cell volume. statistically significant differences in white-cell count and blood coagulation and fibrinolytic activity were found in monkeys which had received alphaxalone-alphadolone. it is suggested that ketamine is a suitable alternative to phencyclidi ...1978102867
the interaction of behavior and reproductive cycles in patas monkeys. 1978104702
identity of euchromatic bands from man to cercopithecidae (cercopithecus aethiops, cercopithecus sabaeus, erythrocebus patas, and miopithecus talapoin).the karyotypes of four species of cercopithecidae: cercopithecus aethiops tantalus, c. sabaeus, erythrocebus patas, and miopithecus talapoin are analysed with nearly all the banding techniques. they are compared with each other, and with the karyotypes of the baboon p. papio and with that of man. it can be concluded that the quasi-totality or the totality of the euchromatin is common to all, but has undergone structural rearrangements, generally detectable. the heterochromatin, defined by c-band ...1978104920
spontaneous preeclamptic toxemia of pregnancy in the patas monkey (erythrocebus patas).a disease characterized by edema, proteinuria, hypoproteinemia and hypertension was seen in late gestation in patas monkeys. the initial sign was edema of the perineum, ankles and lower trunk. the onset was abrupt, occurring 7 days or less prepartum. the affected animals were not depressed, and convulsions were not seen. in 6 of the 98 pregnancies during a 1-year period, symptoms of the disease were present. the highest incidence was manifested by primiparous animals with 3 of 36 pregnancies aff ...1979108469
mycobacterium scrofulaceum infection in erythrocebus patas monkeys.mycobacterium scrofulaceum was cultured from two of seven tuberculin reactors in a group of 12 erythrocebus patas monkeys. one monkey reacted atypically to 0.1 ml of 2.5 mg veterinary tuberculin after having shown no reaction to four previous tests administered at 2-week intervals. the reaction consisted of edema with no induration or erythema at 24 hours and was completely dissipated at 36 hours. responses to additional tests using veterinary tuberculin (2.5 mg) and mycobacterium bovis purified ...1979108474
monkeys as metabolic models for man--the fate of amphetamine in the vervet and patas monkey [proceedings]. 1979110386
transplacental effects of ethylnitrosourea in a nonhuman primate, erythrocebus patas.a breeding colony of the old world monkey erythrocebus patas, an african species, has been established to study transplacental carcinogensis in a representative primate species. enu was administered by repeated iv injections to pregnant females and to juveniles of both sexes. repeated doses of 0.1 mmole/kg body weight per injection, given at 14-day intervals, are tolerated without apparent signs of toxicity by fetal and by pregnant and nonpregnant adult or juvenile monkeys. the internal can be r ...1979113683
immunofluorescent and immunoelectron microscopic demonstration of primate heart muscle antigens cross-reactive with streptococcus pyogenes.the presence of antigens in heart muscles cross-reactive with antibodies against streptococcus pyogenes were examined in heart samples of seven primate species (chimpanzee, rhesus macaque, stump-tailed macaque, hamadryas baboon, capuchin monkey, green monkey and patas monkey). cross-reactive antigens were localized by means of the indirect immunofluorescent technique in nearly all samples tested. the fluorescence pattern was the same as found in the heart muscle of other mammals. using the indir ...1979116866
varicella-zoster virus immunizes patas monkeys against simian varicella-like disease.to define further the antigenic relationship between human varicella-zoster virus and herpesviruses which produce varicella-like disease in certain simian species, patas monkeys were inoculated with varicella-zoster virus and then challenged with delta herpesvirus, which uniformly produces severe, clinically apparent disease in susceptible animals. protection against delta herpesvirus was conferred both by hyperimmunization with varicella-zoster virus and by a single immunization with a cell-fre ...1979215708
jos virus infection in domestic animals and primates. pathogenicity and immunological studies.three species of domestic animals (rabbits, sheep and goats) and two species of primates erythrocebus patas monkeys and baboon (papio anubis) were infected with jos virus. none of the infected animals developed viraemia or overt clinical disease. complement-fixing and neutralising antibodies were demonstrated in sera of infected animals.197941441
the primates in darfur, republic of sudan.the paper describes the distribution, group size and relative abundance of erythrocebus patas and papio doguera in darfur province, sudan. less detailed information is given on cercopithecus aethiops and galago senegalensis. detailed observations were carried out in the field and by low-level aerial survey during 1972--1978 and have been supplemented by references to the literature where appropriate.1979116947
short-term effects of aflatoxin b1 on serum lipids in subhuman primates.aflatoxin b1 significantly depressed serum lipid levels in specimens of cercopithecus aethiops, cercopithecus mona, erythrocebus patas and papio anubis. serum cholesterol, total phospholipids and total lipids were not affected to the same extent.1979113622
the evoked cochlear mechanical response in laboratory primates. a preliminary report.the evoked cochlear mechanical response has been recorded in two species of laboratory primates, macaca irus and erythrocebus patas. the responses are very similar to those obtained in humans although the response to each click is of shorter duration. the response is vulnerable to the ototoxicity of furosemide and etacrynic acid and to noise exposure. at and near threshold an active generator of mechanical energy within the cochlea is proposed. the significance of such a generator and a possible ...1979114151
effects of d-norgestrel-releasing intracervical devices in the nonhuman primate, erythrocebus patas.primates (erythrocebus patas) were implanted with intracervical devices which slowly released d-norgestrel at either of two rates: 38 +/- 12 microgram/day (high dose, 4 animals) or 14 +/- 10 microgram/day (low dose, 3 animals). an additional 8 animals received placebo devices or were untreated controls. all animals were studied for 3 months of exposure, at which time they were necropsied and evaluated. the uterus in all of the high dose primates had endometrial stromal and epithelial hyperplasia ...19807449389
simian haemorrhagic fever (shf): new virus isolate from a chronically infected patas monkey.a new strain of simian haemorrhagic fever (shf) virus was isolated from chronically infected patas monkey no. 248 (p-248) in usu-104 cells. the p-248 isolate had the same size, morphology and cytoplasmic site of replication as the prototype lvr strain. however, the p-248 isolate caused a persistent infection without noticeable cytopathology in usu-104 cells rather than the strongly lytic infection produced by prototype lvr virus. the capacity of p-248 virus to produce a persistent, non-lytic inf ...19806161999
ineffectiveness of adenine arabinoside and adenine arabinoside 5'-monophosphate in simian varicella infection.adenine arabinoside and adenine arabinoside 5'-monophosphate (ara-amp) have been evaluated for antiviral activity against simian varicella virus infection in monkeys. in a preliminary study for toxicity, intramuscular injection of ara-amp at 15 mg/kg per day as a single injection for 5 days to two normal patas monkeys caused no detectable local reaction, no weight loss or changes in serum transaminase levels, and no hematological abnormalities. when this dose was given in the treatment of four s ...19806158291
method to detect asymptomatic carriers of simian hemorrhagic fever virus.evidence was obtained that mononuclear phagocytic cells are the target cells for simian hemorrhagic fever virus replication. using peritoneal macrophages from rhesus monkeys in an in vitro, 18 of 20 asymptomatic chronically infected patas monkeys were detected from coded samples. the two chronically infected patas monkeys not detected by the test, nevertheless, contained virus. this was determined by inoculating macrophage cultures with plasma from macaques dying as a result of inoculation with ...19806257971
social organization in a group of free-ranging patas monkeys.a free-ranging group of patas monkeys (erythrocebus patas) was studied at the caribbean primate research center through parts of a complete seasonal cycle. analysis of the data revealed that dispersal was the major strategy utilized by individuals in the performance of intragroup social behavior. dominance phenomena were not found to be of major importance in the organization of intragroup social behavior despite the presence of a linear, stable dominance hierarchy among the adult females. the d ...19807216002
atherosclerosis in the erythrocebus patas, an old world monkey.fifty monkeys of the species erythrocebus patas were fed a control monkey chow, a semi-synthetic diet containing 25% lard, or a semisynthetic diet containing 25% lard and 0.5% cholesterol for 2 years. the patas monkeys had naturally occurring atherosclerosis that was greatly accelerated by feeding a diet containing cholesterol. the atherosclerosis involved the aorta, predominantly the abdominal portion, the coronary arteries, and various peripheral vessels. histologically, the atherosclerosis wa ...19806766672
gross structure and function of the quadriceps femoris in lemur fulvus: an analysis based on telemetered electromyography.analysis based on telemetered electromyography from the quadriceps femoris of lemur fulvus, a malagasy prosimian, during walking, galloping, leaping, and a variety of postural behaviors partially confirms and partially contradicts earlier hypothesized functions of this musculoskeletal complex. as predicted on the basis of morphological criteria (large physiological cross-section and long parallel fibers), the vastus lateralis is of special functional significance in leaping. this relatively larg ...19806771412
[schistosoma mansoni experimental schistosomiasis in erythrocebus patas monkeys (author's transl)].a number of erythrocebus patas monkeys have been experimentally infected only once, with schistosoma mansoni local strain. the various parasitological, biological and immunological observations show that e. patas is a very adequate host to schistosoma mansoni and that it develops an intestinal schistosomiasis parasitologically very close to human schistosomiasis. it is noted that in this case of single infection e. patas reactions are the same as the other species generally used in the experimen ...19806772918
dopamine and temperature regulation in the primate: effects of apomorphine and pimozide.the purpose of this study was to determine the effects of a specific dopamine-receptor agonist (apomorphine) and antagonist (pimozide) on temperature regulation in the primate. using 4 rhesus monkeys and 2 patas monkeys as subjects, increasing doses of apomorphine (0.05, 0.1, 0.2, 0.4, 0.6 mg/kg) injected subcutaneously produced a dose-dependent hypothermia associated with sharp elevations in tail-skin and ear pinna temperatures. apomorphine also produced dose-related behavioral responses includ ...19807407631
in vitro study of immunological events in human and experimental schistosomiasis: relationships between cytotoxic antibodies and circulating schistosoma antigens.complement-dependent cytotoxic antibodies were found in 54% of schistosoma mansoni infected patients from burundi and in 69 to 78% of schistosoma mansoni ninfected brazilian patients. the levels of cytotoxic ab were not statistically different in sera from infected mothers and from their newborn children, suggesting a transfer through the placenta. a sandwich radioimmunoassay (sria) and the radioimmunoprecipitaion-peg assay (ripega) technique were used in order to detect respectively total schis ...19807413247
the myoglobin of primates x.the amino acid sequences of skeletal muscle myoglobins from two old-world monkeys, presbytis entellus and erythrocebus patas, as well as one new-world monkey, cebus apella wer inferred by homology of the tryptic and peptic peptides with the known sequence of human myoglobin and by selective dansyl-edman degradation. these new sequences were examined phylogentically in conjunction with the 15 primate sequences already reported. it is clear that myoglobin evolution has been extremely conservative ...19807417495
cost of locomotion and heat balance during rest and running from 0 to 55 degrees c in a patas monkey.a young patas monkey was run on a treadmill for 15-20 min at speeds in excess of 15 km times h-1 over a range of laboratory air temperatures from 0 to 55 degrees c. cost of locomotion for the monkey was 83% that predicted for a running mammal of similar weight, 4 kg. at the highest steady-state running of speeds, the patas monkey's energy expenditure was 11 times the resting rate. heat storage and respiratory evaporation during running each accounted for less than 16% of the heat production. cut ...19807429901
acyclovir treatment of experimental simian varicella infection of monkeys.replication of simian varicella virus (svv) in vero cell cultures was inhibited by acyclovir, 9-(2-hydroxyethoxymethyl)guanine (acv), at a concentration of 10 micrograms/ml in culture medium. intravenous administration of acv at 10 mg/kg twice a day for 10 days or 15 mg/kg three times a day for 5 days to patas monkeys (erythrocebus patas) beginning 48 h after svv inoculation blocked the appearance of rash and other clinical symptoms but did not affect viremia. acv treatment of african green monk ...19817305319
domestic breeding of patas monkeys (erythrocebus patas).two reproductive strategies were used in the management of a patas monkey (erythrocebus patas) breeding colony. the first strategy involved placement of all animals into one-male harem units for breeding, parturition, and infant rearing. the second strategy involved a reduction in the number of males, movement of pregnant females to individual cages, and formation of new groups with females and neonates. the second strategy resulted in an increased percentage of females having successful births ...19817311469
the prostate of the nonhuman primate: normal anatomy and pathology.the caudal and cranial prostate of different species of nonhuman primates were examined for histologic characteristics and pathological abnormalities. one hundred specimens from 12 species were represented. among the pathologies found were: 1) cystic hyperplasia; 2) fibromuscular hyperplasia; 3) squamous metaplasia; 4) chronic and acute bacterial prostatitis; 5) prostate adenocarcinoma; and 6) other miscellaneous pathologic changes. a historical review of histological characteristics and patholo ...19817279812
studies on the biotransformation of indoramin in the patas monkey.1. studies on absorption, excretion and biotransformation of the antihypertensive agent indoramin (3-[2-(4-benzamidopiperidino)ethyl]indole hydrochloride) have been carried out in patas monkeys. 2. absorption of the drug was extensive, as indicated by less than 8% of the dose appearing in faeces as the unchanged compound. 3. approx. 35% of an orally administered dose of the 3h-labelled drug was recovered in urine while a similar amount was found in faeces. urinary excretion of total 3h was mono- ...19817336756
pathology of gestational choriocarcinoma induced in patas monkeys by ethylnitrosourea given during pregnancy.a rapidly fatal neoplastic disease with histological and clinical features resembling gestational choriocarcinoma in humans has been observed in patas monkeys. timed pregnant females were given ethylnitrosourea (enu) intravenously at doses of 0.1 to 0.4 mmol/kg body weight, beginning on day 30 of gestation and continuing weekly for a total of 12 injections. of 59 monkeys given enu during pregnancy, four of 12 subjected to the highest dose and three of the remaining 47 given lower doses died of c ...19816963958
susceptibility of laboratory primates to infection with mansonella ozzardi from man.the study was undertaken to determine primates were susceptible to infection with caribbean and/or amazon strains of mansonella ozzardi of man. twenty-three animals including three chimpanzees, four squirrel monkeys, one capuchin, five rhesus and 10 patas monkeys each received, by subcutaneous or intraperitoneal injection, 25-170 infective larvae of m. ozzardi harvested either from infected culicoides furens collected in haiti or simulium sp. (sanguineum complex) collected in the colombian amazo ...19817020456
recovery from monocular deprivation in the monkey. i. reversal of physiological effects in the visual cortex.this is a study of the effects of monocular deprivation, reverse suturing (opening the deprived eye with closure of the other) and reopening of the deprived eye alone (without closing the other) on the physiological organization of the primary visual cortex in monkeys (erythrocebus patas). all animals were initially monocularly deprived by suture of the lids of the right eye from soon after birth until about 4 weeks of age (24-29 days). in a monocularly deprived animal, recordings were taken fro ...19816119688
fatal herpesvirus infection in patas monkeys and a black and white colobus monkey.fatal herpesvirus infections were diagnosed in 3 patas monkeys and 1 black and white colobus monkey over a 4-week period. herpesvirus was isolated from 1 patas monkey and from the black and white colobus monkey. both isolates had growth characteristics similar to herpesvirus hominis and herpesvirus simiae. the isolate from the colobus monkey antigenically appeared to be h simiae or h simiae-like, whereas the isolate from the patas monkey could not be conclusively identified with the antisera use ...19816276349
a system for the continuous collection of 14co2 from patas monkeys: the metabolism of [14c]cloguanamile.1. an apparatus is described that allows co2 expired by monkeys to be trapped and measured and urine and faeces to be separated and collected. 2. when [14c]cloguanamile was administered to rats and to patas monkeys, a marked species difference was seen in the proportion of 14co2 expired. 3. suppression of the gut flora by neomycin revealed that this difference was due to enterofloral metabolism.19816805138
serum prolactin concentrations in mangabey (cercocebus atys lunulatus) and patas (erythrocebus patas) monkeys in response to stress, ketamine, trh, sulpiride and levodopa.an homologous radioimmunoassay for human serum prolactin was validated to measure serum prolactin in 10 mangabey and 7 patas monkeys. mean basal levels of serum prolactin were almost identical in the males of both species and in immature and mature males. however, basal levels were higher in females than in males. serum prolactin was enhanced by stress, i.v. injection of trh and intramuscular injection of a potent dopamine antagonist (sulpiride). the rise in serum prolactin observed after i.m. i ...19816785431
recovery from monocular deprivation in the monkey. ii. reversal of morphological effects in the lateral geniculate nucleus.the cross-sectional area was measured of neurons in the lateral geniculate nucleus (l.g.n.) of monkeys (erythrocebus patas) subjected to monocular deprivation by unilateral eyelid suture, and of others in which the closed lids had been subsequently opened (either alone, "reopening', or together with closure of the previously open eye, "reverse suture'). monocular deprivation for the first month of the monkey's life retards l.g.n. cell growth such that neurons in the laminae innervated by the clo ...19816119689
recovery from monocular deprivation in the monkey. iii. reversal of anatomical effects in the visual cortex.transneuronal autoradiography was used to study the effects of visual deprivation on the ocular dominance stripes in layer ivc of the striated cortex of erythrocebus patas (old world) monkeys. the animals were studied after: (a) 21-28 days of monocular deprivation starting at, or within, a few days of birth; (b) the same treatment followed by a further 3, 6, 15 or 126 days of monocular vision through both eyes (reopening). one other monkey was monocularly deprived from birth to 1890 days. in mos ...19816119690
detection of g-c rich heterochromatin by 5-azacytidine in mammals.a new effect of 5-acr (5-azacytidine), observed in fibroblast or kidney cell cultures is described in the calf (bos taurus) and in some selected primates (cebus capucinus, erythrocebus patas, and cercopithecus cephus). this cytidine analogue, used at low doses during the last late s phase, prevents the condensation of r-band positive heterochromatin (g-c rich segments). thus, 5-acr treatment can be used as a simple method for the detection of g-c rich heterochromatin.19816164628
studies on norgestrel-releasing intrauterine devices in erythrocebus patas monkeys. 19816114061
[a suspected case of tetanus in a patas monkey (erythrocebus patas)]. 19827157334
complement components c3, c4, and bf in six nonhuman primate species.the extent of cross reactivity between antisera to human complement proteins [the third (c3) and fourth (c4) components and factor b (bf)] and these proteins in the sera of six species of nonhuman primates was examined. strong cross reactivity was found with these antisera and the specific complement proteins from rhesus monkeys, stumptailed macaques, cynomolgus macaques, patas monkeys, african green monkeys, and squirrel monkeys. although molecular differences were apparent as indicated by diff ...19826804713
simian varicella virus (delta herpesvirus) infection of patas monkeys leading to pneumonia and encephalitis. 19826278510
multinodular splenic abnormality in a red patas monkey. 19827090159
in vivo and in vitro characteristics of eccrine sweating in patas and rhesus monkeys.biopsy specimens from the chest, palm, back, and lateral calf were obtained from three patas (4-6 kg) and two rhesus monkeys (6 and 8 kg) tranquilized with ketamine hydrochloride (10 mg/kg). the eccrine sweat glands of the specimens were subsequently isolated under a stereomicroscope and prepared for analysis. in both palmar and hairy skin (chest, lateral calf) patas eccrine glands were larger than those isolated from corresponding sites obtained from the rhesus specimens. in vitro stimulation o ...19826749777
mansonella ozzardi: a redescription with comments on its taxonomic relationships.mansonella ozzardi is redescribed from adult worms collected from the subcutaneous tissues of patas monkeys (erythrocebus patas) infected with a haitian strain of the filaria. the worms are small and very slender; females measure about 49 mm in length by 0.15 mm in diameter and males, 26 by 0.07 mm. haitian (caribbean) and colombian (amazon) forms of the filaria are morphologically identical, as are their microfilariae. mansonella is most closely related to tetrapetalonema. based on taxonomic pr ...19826756178
phencyclidine in combination with pentobarbital: supra-additive effects on complex operant behavior in patas monkeys.in one component of a multiple schedule, patas monkeys acquired a different four-response chain each session by responding sequentially on three keys in the presence of four geometric forms (learning). in the other component, the four-response chain was the same each session (performance). the response chain in each component was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. when administered alone, phencyclidine and pe ...19827058207
ultrastructure of experimental coronary artery atherosclerosis in cynomolgus macaques. a comparison with the lesions of other primates.we studied the ultrastructure of the left anterior descending coronary artery in 6 female cynomolgus macaques fed atherogenic food containing 0.5% cholesterol for 6 months, and in 2 female cynomolgus macaques that had received food low in cholesterol. animals given the atherogenic food had coronary artery lesions of a characteristic two-level architecture consisting of a lipid-poor upper cap, and of a lipid-rich lower core. the cap consisted of layers of smooth muscle cells that were rich in rou ...19827115459
the disposition of a novel tetrahydroquinoline, tiquinamide, in rats and patas monkeys.the absorption of tiquinamide occurred rapidly and extensively in both rats and patas monkeys. the major site of localization of radioactivity was in the stomach in both species. tiquinamide was 50-60% bound to rat plasma and 50-75% to monkey plasma. the elimination of unchanged drug from plasma took place rapidly, with half lives of 1.6 h in rats and 0.7 h in monkeys. elimination of total radioactivity in the rat was very slow and monoexponential, with a half-life of 90 h. however, in the monke ...19827173271
phencyclidine in combination with pentobarbital: supra-additive effects on complex operant behavior in pigeons.pigeons acquired a different four-response chain each session by responding sequentially on three keys in the presence of four colors. the response chain was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. when phencyclidine was administered alone, the overall response rate decreased and the percent errors increased with increasing doses. similar effects were found with a high dose of pentobarbital alone. when phencyclidi ...19827134244
[electrophoretic polymorphism in erythrocebus patas].variations were observed at the prealbumin-2, carbonic anhydrase-i, 6-phosphogluconate dehydrogenase, phosphoglucomutase-ii and adenylate kinase loci in erythrocebus patas subspecies pyrrhonotus. but the level of heterozygosity was very low compared with those of the different african monkey species studied by the same electrophoretic analysis. the reasons for this low variation are discussed with regard to ethological and genetic structure characteristics of the group studied.19836884907
cryopreservation of third-stage larvae of brugia malayi and dipetalonema viteae.methods are described for the cryopreservation of third-stage larvae of brugia malayi. optimum conditions utilized larvae free from the mosquito host frozen at the rate of -1 degree or -0.8 degrees c per min in medium containing 9% dimethyl sulfoxide and 0.004 m polyvinylpyrrolidone. nonfrozen or thawed larvae were inoculated intraperitoneally into jirds (meriones unguiculatus), the thawed larvae after cryogenic storage for 5-378 days. in general, the percentage of adult worms recovered at necro ...19836683940
thermoregulation in erythrocebus patas: a thermal balance study.a thermal balance study over an ambient temperature (ta) range of 15-40 degrees c was performed on six nonacclimated patas monkeys (erythrocebus patas) weighing between 3.9 and 6.0 kg. o2 consumption, co2 production, mean weighted skin temperature (tsk), rectal temperature (tre), respiratory evaporative water loss (eresp), and total evaporative water loss (etot) were measured continuously after equilibration at each ta. tsk increased as ta increased, whereas tre was maintained between 37.6 and 3 ...19836643195
development of a nonhuman primate model for fetoscopy.twenty-four fetoscopy procedures were performed on 22 monkeys (19 macaca mulatta, one m. fascicularis, two erythrocebus patas) with gestational ages ranging from 66 to 145 days. insertion of the fetoscope without ultrasound guidance was easy in 14 and difficult in ten procedures. amniotic fluid exchange with normal saline, to improve visualization, was successful in eight of 13 procedures. fetal blood sampling was successful in four of nine attempts. nine monkeys aborted within 17 days of the fe ...19836209400
serological investigation of an outbreak of simian varicella in erythrocebus patas monkeys.an epizootic of simian varicella occurring in a colony of erythrocebus patas monkeys was studied serologically by using radioimmunoassay and neutralization tests against (i) a virus strain isolated from an animal that died during the epizootic, (ii) a simian varicella virus strain from an earlier outbreak of simian varicella-like disease at another facility, and (iii) human varicella-zoster virus. serological tests detected more cases of infection among the animals exposed to virus during the ep ...19836313751
studies on the metabolism of the new anti-hypertensive agent, indoramin, in man.the absorption, metabolism and excretion of the new antihypertensive agent indoramin (baratol) have been studied in male volunteers following oral administration of the drug labelled either with 14c or with tritium. absorption of the drug proceeded at moderate rate, peak plasma radioactivity levels being seen by 3 h after dosing. metabolism was extensive as shown by very little unchanged compound appearing in urine. two major urinary metabolites accounting for some 35-40% of the renally excreted ...19836873141
campylobacter jejuni isolated from patas monkeys with diarrhea.campylobacter jejuni was isolated from 11 (46%) of 24 patas monkeys with chronic diarrhea. eight of these 11 (73%) monkey were characterized clinically by mucohemorrhagic diarrhea for periods up to a month followed by loose, semi-formed feces for a 12-month period. half of the monkeys were treated with erythromycin for 10 days and the other half with tetracycline for 10 days, with all responding to treatment. despite treatment, all monkeys again had an outbreak of mucohemorrhagic diarrhea. biops ...19836876739
influence of age, sex, and caging on joint mobility in the patas monkey (erythrocebus patas).normal range of joint mobility in the extremities of the patas monkey, erythrocebus patas, was established for a free-ranging colony of 64 animals at la parguera, puerto rico (caribbean primate research center). eighty-five animals that had been caged (30" x 30" cages) for up to 5 years were used for comparison. passive joint mobility of anesthetized animals was measured with a goniometer. nine parameters (five on the forelimb and four on the hindlimb) were measured on each animal. the data were ...19836881323
differential effects of prototype opioid agonists on the acquisition of conditional discriminations in monkeys.in each of two components of a multiple schedule, patas monkeys were required to respond on a right or left lever depending upon the stimulus combination (a color and a geometric form) presented. reinforcement of a response in the presence of one stimulus (the form) was conditional upon the other stimulus (the color). the completion of a two-member chain of discriminations produced a food pellet. errors produced a brief time-out. one component of the multiple schedule was a repeated-acquisition ...19836887010
fluorescence of experimental atheromatous plaques with hematoporphyrin derivative.fluorescence of hematoporphyrin derivative (hpd) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. we tested the hypothesis that hpd may also be selectively concentrated within atheromatous plaques. 48 h after hpd injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and patas monkey) exhibiting such lesions. no fluorescence could be demonstrated in aortic segm ...19836822671
blood values of free-ranging patas monkeys (erythrocebus patas).free-ranging patas monkeys (erythrocebus patas) from el guayacán island, puerto rico, were surveyed to establish values for the hemogram, serum biochemicals, calcium, and phosphorus. results were tabulated for males and nonpregnant/nonlactating, pregnant, and lactating females. a summary of blood values from previous studies on captive patas monkeys was also tabulated for comparison.19836680146
antibody responses to experimental brugia malayi infections in patas and rhesus monkeys.humoral antibody responses in experimental infections with brugia malayi (subperiodic strain) were compared in two primate species. erythrocebus patas and macaca mulatta. antibody responses were related to the infection protocol and the duration and magnitude of microfilaremia. patas monkeys were uniformly susceptible to infection and characteristically exhibited prolonged microfilaremia; infections in rhesus monkeys produced low and usually microfilaremia. antibody, measured by enzyme linked im ...19836134454
interferon prophylaxis against simian varicella in erythrocebus patas monkeys.erythrocebus patas monkeys were given placebo or human leukocyte interferon (5 x 10(5) units/kg of body weight per day im) for five days during an epizootic of simian varicella. during the 14 days beginning with the first day of treatment, the attack rate for simian varicella was 14.3% (two of 14) among interferon recipients compared to 70% (nine of 13) among placebo recipients (p less than 0.025). excluding animals with antibody to simian varicella when the study began, 18% (two) of 11 interfer ...19836296238
serologic study by enzyme-linked immunosorbent assay of the igm antibody response in the patas monkey following experimental simian varicella virus infection.the time course of igm and igg antibody appearance in sera following experimental simian varicella virus infection in the patas monkey was studied. serum igm and igg antibody to delta herpes virus (dhv) were measured by a double indirect and indirect elisa test, respectively. igm antibody was detected 5-8 days postinfection (p.i.) and igg antibody was present 10-14 days p.i., which was 5-7 days after igm. viremia preceded detectable igm antibody by 2 days. sucrose gradient separation of serum ig ...19846094088
kinetics of virus-specific igg and igm antibody response in patas monkeys experimentally infected with delta herpesvirus by enzyme-linked immunosorbent assay.the kinetics of virus-specific igg and igm antibody response in patas monkeys experimentally infected with delta herpesvirus (dhv), was studied using enzyme-linked immunosorbent assay (elisa). an indirect elisa (ie) test was used for dhv igg determination, whereas a "double sandwich" (triple antibody layer) elisa (dse) test was found to be very sensitive for dhv igm detection. in dse test dhv igg appeared to interfere with igm determination only in sera containing dhv igg levels at least 100 tim ...19846096678
experimental disseminated strongyloidiasis in erythrocebus patas. i. pathology.fatal disseminated disease was induced in ten patas monkeys infected with two southeast asian strains of strongyloides stercoralis. while some animals died within 6 weeks after infection, others controlled their infections until placed on high doses of corticosteroids. larvae were first noted in the stools 11-20 days after transcutaneous exposure to filariform larvae. daily larval counts tended to increase as the infections progressed, but the number of larvae in the stool was not predictive of ...19846731675
experimental disseminated strongyloidiasis in erythrocebus patas. ii. immunology.parasite-specific humoral and cellular immune responses were evaluated in seven erythrocebus patas monkeys experimentally infected with a southeast asian strain of strongyloides stercoralis. most animals developed high titers of anti-larval surface igg antibody (as evaluated by the indirect immunofluorescence test), and all animals tested developed specific ige antibody (as shown by the in vitro histamine release test). modest lymphoproliferative responses to s. stercoralis antigens were demonst ...19846731676
density gradient characterization of the high density lipoproteins in cholesterol-fed hyper- and hyporesponding patas monkeys (erythrocebus patas).diet-induced changes in high density lipoprotein (hdl) density and size were studied in patas monkeys. when the animals were switched from a moderate fat-low cholesterol diet to a high fat-high cholesterol (hfhc) diet, the plasma apoa-i levels increased initially in all of the animals. the apoa-i levels remained elevated in monkeys able to maintain their plasma cholesterol concentrations near basal levels (hyporesponders), but began to decrease in monkeys who became severely hypercholesterolemic ...19846436420
the distribution of serum high density lipoprotein subfractions in non-human primates.the ultracentrifugal flotation patterns in 1.2 g/ml solvent and ultracentrifugal gradient distribution of high density lipoproteins (hdl) from the primates--human, apes and monkeys--were determined, with emphasis on the gorilla species of apes and rhesus monkeys. diets for non-human primates were commercial chow, which is low in cholesterol. molecular weights and protein, cholesterol, phospholipid and triglyceride compositions of various density fractions were determined on human, gorilla and rh ...19846438429
differential effects of phencyclidine and mda on complex operant behavior in monkeys.in one component of a multiple schedule, patas monkeys acquired a different four-response chain each session by responding sequentially on three keys in the presence of four geometric forms (learning). in the other component, the four-response chain was the same each session (performance). the response chain in each component was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. with increasing doses of phencyclidine the ov ...19846494215
mycobacterium bovis infection in primates in dublin zoo: epidemiological aspects and implications for management.an outbreak of tuberculosis in non-human primates was successfully contained in the isolation area of dublin zoo. a mayotte lemur, a lion-tailed macaque, a patas monkey and a siamang gibbon developed tuberculosis, and mycobacterium bovis was isolated from all but the lemur, from which lesions were not cultured. procedures for the prevention of tuberculosis in primate collections and for the management of outbreaks are discussed. the need for typing of the isolated pathogen is emphasized.19846392739
diarrhea in nonhuman primates: a survey of primate colonies for incidence rates and clinical opinion.veterinary clinicians associated with 18 colonies of nonhuman primates were surveyed for their experience with diarrhea disease in colony animals for calendar year 1981. the 1981 diarrhea incidence rate, diarrhea-specific mortality rate and diarrhea case fatality rate for 13,385 monkeys were 10.6%, 1.2% and 11.1%, respectively. it was not possible to incriminate age or type of housing as risk factors for diarrhea, but some species seemed at greater risk than others. erythrocebus patas monkeys ha ...19846513506
antibody response of patas monkeys to experimental infection with delta herpesvirus. 19846723641
phencyclidine in combination with d-amphetamine: differential effects on acquisition and performance of response chains in monkeys.in one component of a multiple schedule, patas monkeys acquired a different four-response chain each session by responding sequentially on three keys in the presence of four geometric forms (learning). in the other component, the four-response chain was the same each session (performance). the response chain in each component was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. when phencyclidine was administered alone, ov ...19846728878
fibrinopeptides a and b of japanese monkey (macaca fuscata) and patas monkey (erythrocebus patas): their amino acid sequences, restricted mutations, and a molecular phylogeny for macaques, guenons, and baboons.amino acid sequences of fibrinopeptides a and b from the macaque, macaca fuscata (japanese monkey) and the guenon, erythrocebus patas (patas monkey) were established. fibrinopeptides a of the monkeys had a sequence identical with those of baboons: ala-asp-thr-gly-glu-gly-asp-phe-leu-ala-glu-gly-gly-gly-val-arg. fibrinopeptides b were 9-residue, "short," peptides with the sequences asn-glu-glu-ser-leu-phe-ser-gly-arg for m. fuscata and asn-glu-glu-val-leu-phe-gly-gly-arg for e. patas. the sequenc ...19853928610
delta-9-tetrahydrocannabinol potentiates the disruptive effects of phencyclidine on repeated acquisition in monkeys.patas monkeys acquired a different four-response chain each session by responding sequentially on three keys or levers in the presence of four discriminative stimuli (geometric forms or numerals). the response chain was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. each day there were four 15-min sessions, with a 10-min intersession interval. cumulative dose-effect curves for phencyclidine were obtained by giving an im ...19853001785
passive joint mobility in patas monkeys (erythrocebus patas): rehabilitation of caged animals after release into a free-ranging environment.a previous study of passive joint mobility in patas monkeys (erythrocebus patas) showed that laboratory-caged animals had significantly greater mobility in most joints than age/sex matched free-ranging monkeys. passive joint mobility on 27 of the same animals was measured 6 months after the caged animals were released onto a 40-hectare island. the results show that within 6 months of becoming free-ranging, typical passive joint mobility is restored. thus, although caging directly affects measure ...19854061570
cocaine potentiates the disruptive effects of phencyclidine on repeated acquisition in monkeys.patas monkeys acquired a different four-response chain each session by responding sequentially on three keys in the presence of four geometric forms. the response chain was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. each day there were four 15-min sessions, with a 10-min intersession interval. cumulative dose-effect curves for phencyclidine were obtained by giving an im injection before each of the four sessions; suc ...19854080768
abolition of spontaneous rhythmic contractions of isolated monkey coronary arteries by diltiazem, nifedipine, verapamil and nicorandil but not by nitroglycerin.three of 12 coronary artery rings obtained from one of 9 rhesus monkeys (macaca mulatta) (113 rings in all) and 4 of 12 coronary artery rings obtained from one of 2 patas monkeys (erythrocebus patas patas) (28 rings in all) developed spontaneous rhythmic contractions. in 5 of these 7 coronary artery rings, rhythmic contractions occurred long enough to be subjected to examinations of drug effects. in these preparations the effects of the calcium entry blockers, diltiazem, nifedipine and verapamil ...19853157242
loa loa: development and course of patency in experimentally-infected primates.loa loa infections were studied in baboons, rhesus and patas monkeys. animals were infected either by s.c. injection of third-stage larvae (l 3) or by surgical implantation of juvenile worms of known age, sex and number. microfilaremia was first detected in baboons at 140 days following inoculation of l 3 and at 142 days and 143 days in patas and rhesus monkeys, respectively; the mean prepatent period was 151 days in baboons, 149 days in patas monkeys and 169 days in rhesus monkeys. the primary ...19853867108
endocrine profile of pregnancy in the patas monkey (erythrocebus patas).spontaneous toxemia occurs in approximately 6% of pregnancies in patas monkeys (erythrocebus patas). to assess further the relevance of this animal as a model system for toxemia of pregnancy in humans, we characterized the endocrine profile of the patas pregnancy by analyzing weekly blood samples for estrone, estradiol, estriol, progesterone, aldosterone, and pra throughout gestation. the profiles obtained bear striking resemblance to those described for human pregnancy, an unexpected finding si ...19853882395
use of 99mtc-sulfur colloid to assess lymphatic dysfunction in filarial infection.investigations of lymphatic dysfunction in animals infected with filarial parasites has been hampered by a paucity of techniques to measure efficiency of lymphatic drainage. in this study a 99mtc-sulfur colloid technique was used to assess the efficiency of lymphatic drainage in patas monkeys infected with filarial nematodes. in all 15 uninfected hind limbs there was rapid and consistent appearance of labeled colloid in the primary lymph node (popliteal) and subsequently in the secondary nodes ( ...19854095602
naturally occurring yersinia enterocolitica septicemia in patas monkeys (erythrocebus patas).two cases of yersinia enterocolitica septicemia occurred in a breeding group of 22 adult patas monkeys (erythrocebus patas). affected animals had acute clinical signs of depression, weakness, dehydration, hypothermia, hepatomegaly and pronounced leukopenia. both animals died a few hours after treatment was initiated. gross necropsy findings included jaundice, fluid in body cavities, hepatomegaly, splenomegaly, multiple white foci within the liver and spleen, generalized lymph node enlargement an ...19854057942
different effects of epinephrine on the erythrocebus patas tracheal smooth muscle: predominance of alpha-adrenergic receptors. 19852866756
the effect of indoramin on plasma lipids in hypercholesterolemic patas monkeys.in patas monkeys fed a high cholesterol diet, chronic dosing with the antihypertensive agent indoramin increases the cholesterol ratio by raising the plasma hdl-c concentration. epidemiological evidence suggests that increasing hdl-c reduces the incidence of coronary heart disease (chd). if, therefore, indoramin is able to evoke these changes in man it may be expected to favourably influence the progress of chd.19852858569
varicella-like herpesvirus infections of nonhuman primates.at least three distinct herpesviruses cause varicella like exanthematous diseases among nonhuman primates. spontaneous epizootics have resulted in high morbidity and mortality rates among cercopithecus aethiops, erythrocebus patas and macaca species in research colonies. mild infections have been observed in infant chimpanzees and a gorilla. this group of diseases is of interest not only because they are a threat to primate colonies, but also because their pathologic similarity to progressive hu ...19863007865
biology and immunology of human strongyloidiasis.strongyloidiasis is an important human parasitic infection primarily because of its potential for serious and even lethal disease in immunosuppressed patients. certain features of the biology of strongyloides stercoralis, such as the ability to autoinfect the host, help explain why the parasite is dangerous. characteristics of the parasite can also be exploited in parasitological diagnosis of infection with the baermann concentration procedure and by culture. use of filariform larval antigens in ...19863081656
natural infections of vervet monkeys (cercopithecus aethiops) and african red monkeys (erythrocebus patas) in sudan with taeniid cysticerci. 19863503150
differences among isolates of simian hemorrhagic fever (shf) virus.simian hemorrhagic fever (shf) virus is a member of the togaviridae family which currently is unclassified to genus. we have studied the relatedness of four different shf virus isolates obtained from infected macaque or patas monkeys. differences were found among isolates in type and severity of disease produced in patas monkeys, cell sensitivity to infection, viral antigens, and levels of specific antibody induced in patas monkeys. based on these criteria, the four isolates have been grouped in ...19863945613
coxsackie virus b4 produces transient diabetes in nonhuman primates.cynomolgus, rhesus, and cebus monkeys failed to show glucose tolerance or insulin secretion abnormalities after infection with encephalomyocarditis virus or coxsackie virus b4. patas monkeys also showed no abnormalities after infection with encephalomyocarditis virus. however, patas monkeys infected with coxsackie virus b4 or treated first with a subdiabetogenic dose of streptozocin and then infected sequentially with coxsackie viruses b4 and b3 showed transient elevation of glucose tolerance te ...19863011574
elimination of persistent simian hemorrhagic fever (shf) virus infection in patas monkeys.devastating epizootics of simian hemorrhagic fever (shf) have been iatrogenically initiated in captive colonies of macaque monkeys by strains of shf virus emanating from asymptomatic persistently infected patas monkeys. we have found that persistently infected patas monkeys can be cleared of their infection by superinfection with strains of shf virus which cause acute infections in this species. all 20 persistently infected animals subjected to this procedure have been cleared of their infection ...19863945628
nicotine can attenuate the disruptive effects of phencyclidine on repeated acquisition in monkeys.patas monkeys acquired a different four-response chain each session by responding sequentially on three levers in the presence of four discriminative stimuli (numerals). the response chain was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. each day there were four 15-min sessions, with a 10-min intersession interval. cumulative dose-effect curves for phencyclidine were obtained by giving an im injection before each of th ...19863749226
repeated acquisition and delayed performance as a baseline to assess drug effects on retention in monkeys.as an extension of previous research on repeated acquisition, a new baseline was developed to assess the effects of phencyclidine on retention in patas monkeys. each session was divided into three phases: acquisition, delay, and performance. during acquisition, the subject acquired a four-response chain (which was different each session) by responding sequentially on three keys in the presence of four geometric forms. when the acquisition criterion (20 consecutive correct responses) was met, the ...19863749227
effects of mixed agonist-antagonist opioids on the acquisition of conditional discriminations in monkeys.responding in patas monkeys was maintained under a multiple schedule of food presentation. one component of the multiple schedule was a repeated-acquisition task in which the discriminative stimuli for left- and right-key responses changed each session (learning). in the other component, the discriminative stimuli were the same each session (performance). the mixed agonist-antagonists dezocine, gpa 1657 and nalbuphine each produced dose-related decreases in the overall rate of responding in each ...19873806399
homologues of the human c and a apolipoproteins in the macaca fascicularis (cynomolgus) monkey.we used antisera to human a and c apolipoproteins to identify homologues of these proteins among the high-density lipoprotein apoproteins of macaca fascicularis (cynomolgus) monkeys, and nh2-terminal analysis was used to verify the homology. the nh2-terminal sequence of the m. fascicularis apoa-i is identical with that of another old world species, erythrocebus patas, and differs from human apoa-i at only 4 of the first 24 residues. m. fascicularis apoa-ii contains a serine for cysteine replacem ...19873105581
disposition and pharmacokinetics of meptazinol in the csf. studies after intrathecal administration in the non-human primate erythrocebus patas.a preliminary study is reported on the kinetics of meptazinol following intrathecal and i.m. administration in the patas monkey. following intrathecal administration (single dose of 0.5 mg) at t12/l1, meptazinol rapidly disappeared from the csf with a t1/2 of 35 min. at 240 min after intrathecal injection, most of the meptazinol had been distributed within the spinal tissue near the region of the injection, with minimal amounts reaching the brain (less than 5% of the concentrations present in th ...19873663435
effect of ovariectomy on response to dietary cholesterol in patas monkeys (erythrocebus patas).from a group of 20 patas monkeys (erythrocebus patas), four high and four low responders to dietary cholesterol were selected for this study. the monkeys were paired according to their responsiveness to cholesterol, and ovariectomies were carried out on one group of the matched pairs. for the study, the monkeys were fed a prudent diet (at 0.1 mg cholesterol/cal) for 5 months preceding the ovariectomy and for 7 months after the ovariectomy followed by a rich diet (at 0.4 mg cholesterol/cal) for 7 ...19873111879
effects of outer hair cell loss on the frequency selectivity of the patas monkey auditory system.this report describes a study that took advantage of the unique reactivity of the patas monkey (erythrocebus patas) to dihydrostreptomycin-sulfate (dhsm) to investigate the effects of selective outer hair cell (ohc) lesions on psychophysical tuning curves (ptc). four patas monkeys were trained using operant reinforcement techniques to perform forward masking ptcs at frequencies of 500 hz, 2, 4, and 8 khz, at 10 db sl. steady and pulsed-tone thresholds were also measured from 63 hz to 40 khz in h ...19872442130
serological survey and virus isolation of simian t-cell leukemia/t-lymphotropic virus type i (stlv-i) in non-human primates in their native countries.infection with a simian retrovirus (stlv-i) closely related to human t-lymphotropic virus type i (htlv-i) was investigated in non-human primates living in their native countries in africa and asia. serum antibodies cross-reacting with htlv-i antigens were detected in 85 of 567 non-human primates of 30 species. seropositive animals were found among african green monkeys, olive baboons, sykes' monkeys, mandrills and patas monkeys in several countries in africa, and cynomolgus monkeys, celebes maca ...19872440820
effects of kappa agonists and dexoxadrol on the acquisition of conditional discriminations in monkeys.in each of two components of a multiple schedule, patas monkeys were required to respond on a right or left lever depending upon the stimulus combination (a color and a geometric form) presented. reinforcement of a response in the presence of one stimulus (the form) was conditional upon the other stimulus (the color). the completion of a two-member chain of discriminations produced a food pellet. errors produced a brief timeout. one component of the multiple schedule was a repeated-acquisition t ...19872824758
effects of phencyclidine, ketamine and mdma on complex operant behavior in monkeys.in one component of a multiple schedule, patas monkeys acquired a different four-response chain each session by responding sequentially on three levers in the presence of four numerals (acquisition). in the other component, the four-response chain was the same each session (performance). the response chain in each component was maintained by food presentation under a fixed-ratio schedule. after im administration, phencyclidine, ketamine, and mdma (3,4-methylenedioxymethamphetamine or "ecstasy") ...19872883665
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