variation in age at puberty in monkeys.5 female and 3 male patas monkeys and 6 female and 3 male talapoin monkeys matured in a captive breeding colony. age at puberty is given, and some variation discussed. the talapoin, a very small monkey, becomes adult at 4 1/2 years for females, 1 or 2 years later for males. the patas, a rather large monkey, becomes adult at 2 1/2 years, for females, and 1 or 2 years later for males. both these ages for puberty differ from data for the rhesus monkey which has been accepted as generalizable to all ...197718386
the disposition of a novel pyrimidoindole, ciclazindol, in the rat and patas monkey. 197720289
jos virus infection in domestic animals and primates. pathogenicity and immunological studies.three species of domestic animals (rabbits, sheep and goats) and two species of primates erythrocebus patas monkeys and baboon (papio anubis) were infected with jos virus. none of the infected animals developed viraemia or overt clinical disease. complement-fixing and neutralising antibodies were demonstrated in sera of infected animals.197941441
type c viruses from kirsten sarcoma-transformed mink cells co-cultivated with primate cells and expressing p30 antigens related to feline leukemia virus.two type c viruses with new antigenic and biological properties were isolated by co-cultivating secondary cell strains established from the kidneys of a baboon (papio papio) and a patas monkey (erythrocebus patas) with mink cells non-productively transformed by kirsten sarcoma virus. both new isolates (designated pp-1r and ep-1r) contain major structural proteins (p30) that are immunologically most closely related to the p30 proteins of feline leukemia viruses. the reverse transcriptases of both ...197660495
the patas monkey as a model for dihydrostreptomycin ototoxicity.although the cochlear toxicity of dihydrostreptomycin (dhsm) is well-recognized in man, it has always proved difficult to demonstrate in animals. hearing thresholds in m. nemestrina monkeys remained essentially unchanged after dhsm 100 mg/kg im daily for 8 months, but e. patas monkeys were severely deafened by dhsm 20 mg/kg for 90 days, a regimen formerly used in treating human tuberculosis. the patas monkey may prove to be the animal model of choice for evaluating aminoglycoside ototoxicity.197765898
response of erythrocebus patas monkeys to experimental infection with the orbivirus orungo virus.the response of erythrocebus patas monkeys experimentally inoculated by the intravenous and subcutaneous routes with orungo virus (family reoviridae, genus orbivirus) was studied with reference to development of clinical signs, circulation of virus and antibody response. none of the animals showed clinical disease nor did they circulate virus. however, all the animals developed complement fixing (cf), neutralizing (n) and agar gel (ag) precipitating antibodies between day seven and day 14 post i ...197897815
the influence of dose on the pattern of conjugation of phenol and 1-naphthol in non-human primates.1. the pattern of conjugation of phenol and 1-naphthol was investigated in several primates; three old world species (rhesus, cynomolgus, patas monkeys), two new world species (capuchin, tamarin), and two prosimians (bushbaby, tree shrew). 2. following intra-muscular phenol or 1-naphthol (10 mg/kg), sulphation was the major conjugation in the old world monkeys and prosimians, whereas glucuronidation predominated in the new world species. 3. in rhesus and cynomolgus monkeys, sulphation decreased ...197898922
growth and hematologic development of the patas monkey (erythrocebus patas) to one year of from 338 blood samples of 31 patas monkeys is presented to show the normal hematolgoic development from birth to one year of age, and is compared to 120 samples from normal adults. marked changes in hematocrit, hemoglobin, red cell numbers, and leukocyte distribution which occurred during the first month were followed by a slow progression to adult values. body weight data is also presented which shows a linear growth rate during the first year of life.1978101669
the influence of anaesthetics on the haematology of the patas monkey, erythrocebus patas.the effects of phencyclidine, ketamine and an alphaxalone-alphadolone mixture on the haematology of the patas monkeys have been compared. in animals sedated with phencyclidine or ketamine the only significant difference detected was in the mean cell volume. statistically significant differences in white-cell count and blood coagulation and fibrinolytic activity were found in monkeys which had received alphaxalone-alphadolone. it is suggested that ketamine is a suitable alternative to phencyclidi ...1978102867
the interaction of behavior and reproductive cycles in patas monkeys. 1978104702
identity of euchromatic bands from man to cercopithecidae (cercopithecus aethiops, cercopithecus sabaeus, erythrocebus patas, and miopithecus talapoin).the karyotypes of four species of cercopithecidae: cercopithecus aethiops tantalus, c. sabaeus, erythrocebus patas, and miopithecus talapoin are analysed with nearly all the banding techniques. they are compared with each other, and with the karyotypes of the baboon p. papio and with that of man. it can be concluded that the quasi-totality or the totality of the euchromatin is common to all, but has undergone structural rearrangements, generally detectable. the heterochromatin, defined by c-band ...1978104920
spontaneous preeclamptic toxemia of pregnancy in the patas monkey (erythrocebus patas).a disease characterized by edema, proteinuria, hypoproteinemia and hypertension was seen in late gestation in patas monkeys. the initial sign was edema of the perineum, ankles and lower trunk. the onset was abrupt, occurring 7 days or less prepartum. the affected animals were not depressed, and convulsions were not seen. in 6 of the 98 pregnancies during a 1-year period, symptoms of the disease were present. the highest incidence was manifested by primiparous animals with 3 of 36 pregnancies aff ...1979108469
mycobacterium scrofulaceum infection in erythrocebus patas monkeys.mycobacterium scrofulaceum was cultured from two of seven tuberculin reactors in a group of 12 erythrocebus patas monkeys. one monkey reacted atypically to 0.1 ml of 2.5 mg veterinary tuberculin after having shown no reaction to four previous tests administered at 2-week intervals. the reaction consisted of edema with no induration or erythema at 24 hours and was completely dissipated at 36 hours. responses to additional tests using veterinary tuberculin (2.5 mg) and mycobacterium bovis purified ...1979108474
monkeys as metabolic models for man--the fate of amphetamine in the vervet and patas monkey [proceedings]. 1979110386
transplacental effects of ethylnitrosourea in a nonhuman primate, erythrocebus patas.a breeding colony of the old world monkey erythrocebus patas, an african species, has been established to study transplacental carcinogensis in a representative primate species. enu was administered by repeated iv injections to pregnant females and to juveniles of both sexes. repeated doses of 0.1 mmole/kg body weight per injection, given at 14-day intervals, are tolerated without apparent signs of toxicity by fetal and by pregnant and nonpregnant adult or juvenile monkeys. the internal can be r ...1979113683
immunofluorescent and immunoelectron microscopic demonstration of primate heart muscle antigens cross-reactive with streptococcus pyogenes.the presence of antigens in heart muscles cross-reactive with antibodies against streptococcus pyogenes were examined in heart samples of seven primate species (chimpanzee, rhesus macaque, stump-tailed macaque, hamadryas baboon, capuchin monkey, green monkey and patas monkey). cross-reactive antigens were localized by means of the indirect immunofluorescent technique in nearly all samples tested. the fluorescence pattern was the same as found in the heart muscle of other mammals. using the indir ...1979116866
[demonstration by immunofluorescence of somatotropic cells and prolactin cells in the monkeys erythrocebus patas, cercopithecus aethiops and papio hamadryas].using antibodies against human sth and ovine prolactine, it is possible to identify somatotropic and prolactin cells in the pituitary anterior lobe of three species of monkeys: erythrocebus patas, cercopithecus aethiops and papio hamadryas. the somatotropic cells are numerous in both adult and infant male or female monkeys, especially in the lateral lobes of the pituitary gland. the prolactin cells can be distinguished in all pituitaries studied, regardless age or sex; indeed there are more nume ...1976140737
immunological relationship between delta herpesvirus of patas monkeys and varicells-zoster virus of humans.the delta herpesvirus (dhv) which produced outbreaks of exanthematous disease in patas monkeys was shown to have a close immunological relationship to varicella-zoster (v-z) virus of man. immunization of rhesus monkeys with dhv or v-z virus resulted in the development of neutralizing antibodies to both viruses and also in the production of complement-fixing antibodies to v-z virus. immunoglobulin m neutralizing antibody to v-z virus was demonstrated in the serum of a rhesus monkey immunized with ...1975168152
characterization of the plasma lipoproteins and apoproteins of the erythrocebus patas monkey.patas monkey lipoproteins were fractionated into four distinct classes by a combination of ultracentrifugation and geon-pevikon block electrophoresis and characterized with respect to their chemical and physical properties. very low density lipoproteins (vldl) were isolated at d is less than 1.006, were triglyceride rich, and were in the size range 300-850 a. they were similar in apoprotein content to the vldl of man, dog, and swine. the patas monkey low density lipoprotein referred to as ldl-i ...1976178359
atherogenic hyperlipoproteinemia induced by cholesterol feeding the patas monkey.patas monkeys were studied for 2 years on three dietary regimes: (1) commercial chow (control diet); (2) semipurified diet plus lard (fat-fed); and (3) semipurified diet plus lard and cholesterol (cholesterol-fed). the control and fat-fed animals had similar lipoproteins which were equivalent to the human very low density, low density (ldl), and high density lipoproteins. an additional lipoprotein referred to as ldl-ii appeared to be equivalent to the human lp(a). the cholesterol-fed animals dev ...1976182200
serum lipid and lipoprotein responses of six nonhuman primate species to dietary changes in cholesterol levels.the response of serum lipids and lipoproteins to different levels of cholesterol in the diet was studied in chimpanzee (pan troglodytes), rhesus (macaca mulatta), green (cercopithecus aethiops), patas (erythrocebus patas), squirrel (saimiri sciurea) and spider (ateles sp.) monkeys. five animals of each species were fed increasing amounts of dietary cholesterol (0.05% to 1.5% w/w) for 3-week periods; between each experimental diet, the animals were fed a basal diet without cholesterol for a simil ...1976186573
antigenic relationships among several simian varicella-like viruses and varicella-zoster virus.cross-neutralization and complement fixation tests demonstrated the immunological identity of the delta herpesvirus, the 592s virus, the liverpool vervet monkey virus, the herpesvirus of patas monkeys, and the medical lake macaque virus. these viruses were isolated from diverse outbreaks of varicella-like disease in simians and from various simian species. all of the simian viruses were shown to be related to human varicella-zoster (v-z) virus, as evidenced by the fact that immunization of monke ...1977192676
[tumors of the liver, biliary tracts and pancreas in monkeys].the article deals with spontaneous tumours of the liver, biliary tract, and pancreas observed in monkeys of the sukhumi simian nursery during the period of 1960--1974. among tumours of the liver hepatoadenomas predominated: they were revealed in 4 macaco rhesuses, one green marmoset. in a young baboon hamadryad adenomatous hyperplasia was observed to be developed against the background of hepatocirrhosis. all three cases of tumours of the biliary tract in baboons hamadryad were classified as ade ...1977193473
[demonstration by immunofluorescence of adenohyphysis corticotropin and melanotropin cells in erythrocebus patas, cercopithecus aethiops and papio hamadryas].using antibodies against synthetic corticotropic hormones (1-24 acth and 17-39 acth), and melanotropic hormones (alpha-msh and beta-msh), it is possible to identify corticotropic and melanotropic cells in the adenohypophysis of three species of monkeys : erythrocebus patas, cercopithecus aethiops and papio hamadryas. the corticotropic cells are numerous in the anterior lobe in both the adult and infant male and female monkeys of these three species. the intermediate lobe reacts with antibodies a ...1977196718
nonhuman primates: laboratory animals of choice for neurophysiologic studies of sleep.a systematic study was made of several nonhuman primates to learn more about their relative usefulness for studies of sleep. species studied included the guinea baboon (papio papio), kenya or yellow baboon (p cynocephalus), olive baboon (p anubis), sacred baboon (p hamadryas), vervet monkey (cercopithecus aethiops), rhesus monkey (macaca mulatta), bonnet monkey (m radiata), crab-eating monkey (m fascicularis), patas monkey (erythrocebus patas), chimpanzee (pan troglodytes), mongoose lemur (lemur ...1977201798
phosphonoacetic acid in the treatment of simian varicella.phosphonoacetic acid inhibited replication of simian varicella virus (delta herpesvirus) in tissue culture. the drug was tested in patas monkeys 40 h after infection with delta herpesvirus. a total of 200 mg/kg per day was given intramuscularly, divided into two doses every day for a total of 10 days. the treated monkeys were protected from clinical illness, and delta herpesvirus was not recovered from their lymphocytes. complement-fixing and neutralizing antibody titers were significantly lower ...1978213014
varicella-zoster virus immunizes patas monkeys against simian varicella-like define further the antigenic relationship between human varicella-zoster virus and herpesviruses which produce varicella-like disease in certain simian species, patas monkeys were inoculated with varicella-zoster virus and then challenged with delta herpesvirus, which uniformly produces severe, clinically apparent disease in susceptible animals. protection against delta herpesvirus was conferred both by hyperimmunization with varicella-zoster virus and by a single immunization with a cell-fre ...1979215708
patas monkey (erythrocebus patas) naturally infected with schistosoma mansoni. 1977403268
placental infarction: a sign of pre-eclampsia in a patas monkey (erythrocebus patas). 1977403372
radioimmunoassay of human plasma lp(a) lipoprotein.a quantitative immunodiffusion assay demonstrated lp(a) lipoprotein in 91% (911 of 1000) of subjects. in order to quantitate lp(a) in all plasma, a sensitive and specific double antibody radioimmunoassay was developed. the between-assay coefficient of variation was 8%. lp(a) levels by radioimmunoassay were highly correlated with those obtained by the less sensitive radial immunodiffusion method (r = 0.98, n = 51). all but one of the 89 lp(a) "negative" subjects by immunodiffusion had detectable ...1977405443
[steroid metabolism in primates. xix. urinary excretion of c21-steroids in cercopithecus aethiops and erythrocebus patas].in male cercopithecus aethiops (green monkey; grivet) and erythrocebus patas (dancing red monkey; patas monkey), the pattern of urinary c21 steroids was estimated and compared with those of man, baboon and rhesus monkey. the results indicate diminished 11 beta- and 17 alpha-hydroxylation in steroid biosynthesis as well as diminished delta 4-3-keto reduction and increased 20 beta-reduction in metabolism in these two species.1977411649
disseminated cryptococcosis in a patas monkey (erythrocebus patas).cryptococcosis was diagnosed in an adult male patas monkey (erythrocebus patas) 9 months after importation. the disease was characterized by an open lesion on the buttock and epileptiform seizures. diagnosis was confirmed through immunologic identification of the organism in serum and cerebrospinal fluid and by mycologic procedures performed on the cultured organism. the monkey was killed and cryptococcal organisms were found in the lung, brain, subcutaneous lesions, thyroid, pancreas, adrenals, ...1977413001
schistosoma intercalatum fisher, 1934 (cameroon) infection in the patas monkey (erythrocebus patas schreber, 1775). 1978415994
exocrine pancreatic function in protein-deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test.exocrine pancreatic secretion was studied in 9 patas monkeys before and during protein depletion, and in 4 of them also during recovery from protein depletion. pancreatic function was estimated by measuring enzymatic activities in the duodenal contents after a test meal and by determination of urinary excretion of p-aminobenzoic acid (pancreatic function test) after oral ingestion of the chymotrypsin-labile peptide n-benzoyl-l-tyrosyl-p-aminobenzoic acid. the average serum albumin dropped by 34. ...1975803463
a phylogenetic perspective for social behavior in primates.three selected groups of studies of primate social behavior and development are discussed. in the first group of studies the social development of rhesus monkeys reared in different environments is considered. rhesus show remarkable similarity in behavior in diverse environments, demonstrating a phylogenetic set to develop species-typical behavioral repertoires. the second set of studies reports on three species (macaca mulatta, macaca fasicularis, and erythrocebus patas) reared in similar setti ...1975803553
biochemical parameters in the patas monkey.various difficulties are encountered when applying certain routine clinical chemistry procedures to biological material from patas monkeys. the wide range of results found in the immature monkey, together with findings which in the human subject would be grossly abnormal, are described.1975804071
t-strain mucoplasmas and reproductive failure in monkeys.t-strain mycoplasmas were isolated from the genital tracts of 3 genera of female monkeys: the talapoins, miopithecas talapoin, the patas, erythrocebus patas, and the macaques, macaca fascicularis. the talapoins have not reproduced successfully for the past 2 yr. fertility in the patas has also been reduced, with a high incidence of stillbirths and spontaneous abortions. the macaques were not permitted to breed.1975805883
loa loa: experimental infection in two species of african primates.four species of primates, baboon (papio anubis), patas monkeys (erythrocebus patas), green monkey (cercopithecus aethiops) and chimpanzee (pan troglodytes) were inoculated with third-stage larvae of a human strain of loa loa from cameroon, west african. the baboon and patas monkeys developed patent infections after 135 to 148 days; the green monkeys and chimpanzee did not. in each animal which became patent, microfilaremia rose rapidly to high levels. in the baboon, but not in the patas monkeys, ...1975808145
experimental schistosomiasis haematobia in bushbaby (galago crassicaudatus), patas (erythrocebus patas), and grivet (cercopithecus aethiops).the bushbaby (galago crassicaudatus), patas (erythrocebus patas), and grivet (cercopithecus aethiops) have been evaluated as hosts in experimental schistosomiasis haematobia. individual hosts demonstrated considerable variation in host-parasite relationships. e. patas is suggested as a host for continuing investigations in schistosoma haematobium infections, based upon its moderate susceptibility to infection and a moderate potential for pathological involvement of the urogenital system.1975808620
[concentrating ability of the gallbladder: a comparative study in some vertebrate species (author's transl)].the bile salts, chloride, sodium, potassium and nitrogen content of the gallbladder bile was studied in goat, sheep, cattle, pig, rabbit, dog, monkey (erythrocebus patas), chicken, lizard (lacerta ocellata), frog (rana esculenta), trout (salmo gardnieri) and barbel (barbus barbus). a significant correlation was found between bile salts and sodium (positive), chloride and sodium (negative) and chloride and bile salts (negative). the gallbladder concentrating ability was very high in monkey, lizar ...1975808839
intestinal absorption, exocrine pancreatic function and response to vibrio cholerae infection in protein deficient patas monkeys (erythrocebus patas).six patas monkeys (erythrocebus patas) were fed a protein-free diet. sixteen animals of the same species received a standard monkey diet. the protein-depleted patas showed reduced absorption of folic acid but not d-xylose, and 5 out of 6 had a decrease in the exocrine pancreatic function. animals with reduced folic acid absorption and pancreatic enzyme production developed a longer lasting diarrhoea and excreted the microorganisms for a longer time when challenged with vibrio cholerae.1975809870
the copulatory behaviour of adult male patas monkeys, erythrocebus patas. 1975811794
transmission of creutzfeldt-jakob disease to the patas monkey (erythrocebus patas) with cytopathological changes in in vitro cultivated brain cells.the transmission of creutzfeldt-jakob disease (cjd) to the patas monkey, erythrocebus patas, has been accomplished. clinical neurological disease was first noticed 47 months and 23 days after intracerebral inoculation of infected squirrel monkey brain. the disease progressed slowly and lasted 8 months. microscopic examination of the brain and spinal cord revealed lesions of status spongiosus and astrogliosis in the cortical gray matter consistent with a diagnosis of experimental cjd. a vacuolati ...1975823126
pharmacokinetics and metabolism of the new analgesic meptazinol in rats and patas monkeys.1. the absorption of meptazinol following oral administration to rats and monkeys was extensive, 63-88% of the administered dose being recovered in the urine. however, the rate of absorption was slower in the monkey than that in the rat. 2. distribution studies showed higher concentrations of unchanged drug in tissues and plasma of rats than in those of monkeys after the same dosage. 3. elimination of the drug from plasma occurred rapidly in both species. the major route of excretion was the uri ...1976824868
hormone-releasing silastic intrauterine devices: effect or provera-releasing intrauterine devices on two species of primates.silastic intrauterine contraceptive devices (iuds) 13 mm long and 1.07 mm in diameter could be inserted easily into patas monkey uteri which, like human uteri, expelled them. addition of 10% provera to these devices did not reduce the expulsion rate significantly in our study. control devices had no effect on cycle length in rhesus monkeys. after insertion, the active iuds frequently caused a delay in onset of menstruation; however, cycles did occur with the device in situ, and normal-length cyc ...19751171027
[exocrine pancreatic function, intestinal resorption and reaction to vibrio cholerae infection in protein deficiency].six patas monkeys were fed a protein-free diet while 16 animals of the same species receoved a standard monkey diet. the protein-depleted monkeys showed reduced absorption of folic acid but not dxylose, and 5 out of 6 exhibited depressed exocrine pancreatic function. when challenged with vibrio cholerae, animals with reduced folic acid absorption and pancreatic enzyme production excreted the micro-organisms for a longer time.19761257727
induction of various cytochromes cyp2b, cyp2c and cyp3a by phenobarbitone in non-human primates.male and female patas (erythrocebus patas) and cynomolgus (macaca fascicularis) monkeys were treated with phenobarbitone (pb) and examined for the induction of various cytochrome p450 (p450)-mediated drug metabolizing enzymes. hydroxylation of testosterone at the 6 beta, 2 beta, and 15 beta positions, metabolites normally associated with cyp3a p450s increased 2- to 5-fold in pb-treated animals. induction of this p450 family was confirmed by the use of polyclonal antisera directed against the hum ...19921306117
cloning and sequences of primate cd4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency study the interaction between the primate lentiviruses simian immunodeficiency virus (siv) and human immunodeficiency virus (hiv) and the cd4 receptor we have cloned and sequenced the cd4 molecule from six non-human primate species: african green monkeys (three subspecies: sabeus, pytherethrus, aethiops), sooty mangabeys, patas monkeys, chimpanzees, rhesus macaques, and pig-tail macaques. molecular cdna clones representing cd4 mrna were generated from total rna from peripheral blood mononucle ...19921425921
reduced blood clearance and increased urinary excretion of n-nitrosodimethylamine in patas monkeys exposed to ethanol or isopropyl alcohol.low concentrations of n-nitrosodimethylamine are metabolized in rodent and human liver by cytochrome p450iie1, an activity competitively inhibitable by ethanol. in rodents coadministration of ethanol with n-nitrosodimethylamine results in increased tumorigenicity in extrahepatic organs, probably as a result of reduced hepatic clearance. to test this concept in a primate, the effects of ethanol cotreatment on the pharmacokinetics of n-nitrosodimethylamine were measured in male patas monkeys. etha ...19921540953
treatment of complete atrio-ventricular block in a patas monkey using a permanent cardiac pacemaker. 19911658449
in vitro hiv infection of primate lymphocytes.peripheral blood mononuclear cells (pbmc) obtained from four different primate species were tested for their respective ability to support the "in vitro" replication of the human immunodeficiency viruses, hiv-1, and hiv-2. pbmc of cebus apella, patas (erythrocebus patas), green (cercopithecus aethiops sabaeus) and rhesus monkeys (macaca mulatta) were infected "in vitro" with either hiv-1 or hiv-2. cultures were assayed weekly for particle-associated reverse transcriptase activity. both viruses w ...19901706529
cloning of two human liver bilirubin udp-glucuronosyltransferase cdnas with expression in cos-1 cells.we report the isolation and characterization of two human liver cdna clones, hug-br1 and hug-br2; each encodes a udp-glucuronosyltransferase enzyme which glucuronidates bilirubin ix alpha to form both the ix alpha c8 and ix alpha c12 monoconjugates and a diconjugate. hug-br1 cdna (2351 base pairs) and hug-br2 cdna (2368 base pairs) encode proteins with 533 and 534 amino acid residues, respectively, with a typical membrane-insertion signal peptide, membrane-spanning domain, and 3 or 5 potential a ...19911898728
fatal herpesvirus simiae (b virus) infection in a patas monkey (erythrocebus patas). 19901965586
experimental onchocerca volvulus infections in mangabey monkeys (cercocebus atys) compared to infections in humans and chimpanzees (pan troglodytes).three chimpanzees, three mangabey monkeys (cercocebus atys), and 14 patas monkeys (erythrocebus patas) were inoculated with l3 onchocerca volvulus of guatemalan origin. one chimpanzee and two mangabey monkeys developed antibody activity to at least three different antigens. both mangabey monkeys recognized a 20 kda antigen 3.5-5 months post-inoculation, and the monkeys and the chimpanzee developed antibody activity to 14 and 22 kda antigens 7.5-13 months post-inoculation. one mangabey monkey and ...19912012258
functional and morphological changes in the eccrine sweat gland with heat acclimation.three adult male patas monkeys (11-15 kg) were heat acclimated by continuous exposure to an ambient temperature of 33 +/- 1 degree c at 13% relative humidity for 9 mo. during the last month, they were also exposed to 45 degrees c at 10% relative humidity for 4 h/day and 5 days/wk. before and after 3 wk of acclimation, the animals were given a heat-tolerance test in which rectal (tre) and mean skin (tsk) temperatures, heart rate, and sweat rate (msw) were monitored during a 90-min exposure to 45 ...19902203723
attenuation and immunogenicity in primates of vaccinia virus recombinants expressing human interleukin-2.vector-directed lymphokine expression represents a novel approach to the attenuation of live recombinant viruses which might be used as vaccines. expression of interleukin-2 (il-2) by recombinant vaccinia virus has been shown to significantly attenuate virus virulence in rodent species without diminishing immunogenicity. skin lesion formation and immunogenicity of vaccinia/il-2 recombinants in three species of primates was examined. il-2 expression was associated with a 15-fold reduction in the ...19902316280
interspecies scaling of the pharmacokinetics of n-nitrosodimethylamine.the pharmacokinetics of n-nitrosodimethylamine was studied in patas monkeys following i.v. doses of 0.5, 1.0, and 5.0 mg/kg and a p.o. dose of 1.0 mg/kg, and in swiss mice at i.v. doses of 1.0 and 2.0 mg/kg. in the patas monkey the pharmacokinetics was linear over the i.v. dose range studied. the mean clearance (cl), steady-state volume of distribution (vss), mean residence time, and elimination half-life (t 1/2) were 103.3 +/- 26.7 (sd) ml/min, 3061 +/- 821 ml, 30.8 +/- 10.8 min, and 21.1 +/- 8 ...19902364390
the species-specific nature of the ototoxicity of dihydrostreptomycin in the patas monkey.the remarkable susceptibility of the inner ear of the patas monkey (erythrocebus patas) to the ototoxic action of dihydrostreptomycin (dhsm) (and streptomycin (sm)) is well established in this paper and affords a rare example of a species-specific reaction to a restricted class of compounds within the aminoglycoside group of antibiotics. in a series of experiments, behavioral and morphological observations together provided the following profile of dhsm ototoxicity in the patas monkey: sudden on ...19872436117
serological survey and virus isolation of simian t-cell leukemia/t-lymphotropic virus type i (stlv-i) in non-human primates in their native countries.infection with a simian retrovirus (stlv-i) closely related to human t-lymphotropic virus type i (htlv-i) was investigated in non-human primates living in their native countries in africa and asia. serum antibodies cross-reacting with htlv-i antigens were detected in 85 of 567 non-human primates of 30 species. seropositive animals were found among african green monkeys, olive baboons, sykes' monkeys, mandrills and patas monkeys in several countries in africa, and cynomolgus monkeys, celebes maca ...19872440820
effects of outer hair cell loss on the frequency selectivity of the patas monkey auditory system.this report describes a study that took advantage of the unique reactivity of the patas monkey (erythrocebus patas) to dihydrostreptomycin-sulfate (dhsm) to investigate the effects of selective outer hair cell (ohc) lesions on psychophysical tuning curves (ptc). four patas monkeys were trained using operant reinforcement techniques to perform forward masking ptcs at frequencies of 500 hz, 2, 4, and 8 khz, at 10 db sl. steady and pulsed-tone thresholds were also measured from 63 hz to 40 khz in h ...19872442130
the immune response to nematode parasites: modulation of mast cell numbers and function during strongyloides stercoralis infections in nonhuman primates.mucosal mast cell numbers are modulated in the intestines of rodents during parasitic infections. these mast cells can degranulate in response to worm antigens, and this event has been suggested to play a protective role for the host. to examine whether mast cells in higher animals play a role in protecting from disseminated parasitic disease, mast cell numbers and responsiveness to parasite antigens were evaluated in 5 erythrocebus patas infected with the human intestinal nematode strongyloides ...19882484305
comparative transplacental carcinogenesis by directly acting and metabolism-dependent alkylating agents in rodents and nonhuman primates.transplacental carcinogenesis by n-ethyl-n-nitrosourea (enu) was studied in patas (erythrocebus patas) and rhesus (macaca mulatta) monkeys. repeated intravenous injections throughout pregnancy caused gestational choriocarcinoma in female patas monkeys and a variety of non-trophoblastic neoplasms in their offspring. latent periods for transplacentally induced tumours varied from less than one month to more than ten years. one case of congenital neoplasm was observed. certain kinds of neoplasms we ...19892553598
effect of cerebrospinal fluid hyperosmolality on sweating in the heat-stressed patas monkey.dehydration increases the osmolality of body fluids and decreases the rate of sweating during thermal stress. by localizing osmotic stimuli to central nervous system tissues, this study assessed the role of central stimulation on sweating in a heat-stressed nonhuman primate. lenperone-tranquilized patas monkeys (erythrocebus patas n = 5), exposed to 41 +/- 2 degrees c, were monitored for calf sweat rate, rectal and mean skin temperatures, oxygen consumption, and heart rate during infusions (255- ...19892759936
effects of csf ang ii and avp on sweating in the heat-stressed patas monkey.increasing cerebrospinal fluid [na+] reduces sweat rate (msw) in the heat-stressed patas monkey (erythrocebus patas). this study determined the potential role of two neuropeptides, angiotensin ii (ang ii) and arginine vasopressin (avp), in mediating this response. artificial cerebrospinal fluid, containing either ang ii or avp, was infused into the third cerebral ventricle of lenperone-tranquilized monkeys (n = 4) exposed to 41 +/- 2 degrees c. solutions were infused at 16.5 microliters/min for ...19892759937
studies of free-ranging and corralled patas monkeys at la parguera, puerto rico.patas monkeys (erythrocebus patas) were maintained and studied at the la parguera primate colony between 1971 and 1982. this paper describes the founding of the patas population, its growth, and its eventual termination. the behavioral and biological studies conducted on the la parguera patas monkeys are also described.19892780953
studies of free-ranging patas monkeys at la parguera, puerto rico: 1977 problems and 1988 issues.the first portion of this paper addresses problems associated with studying the free-ranging patas monkeys on the island of guayacan (la parguera). problems included those of the habitat, the animal records and markings, and the behavioral characteristics of the patas. the second portion of this paper addresses the recurring question of the role of kinship as a variable that organizes patas social behavior. as mother-infant interactions comprise the largest proportion of intragenealogical intera ...19892780955
effects of kappa agonists and dexoxadrol on the acquisition of conditional discriminations in each of two components of a multiple schedule, patas monkeys were required to respond on a right or left lever depending upon the stimulus combination (a color and a geometric form) presented. reinforcement of a response in the presence of one stimulus (the form) was conditional upon the other stimulus (the color). the completion of a two-member chain of discriminations produced a food pellet. errors produced a brief timeout. one component of the multiple schedule was a repeated-acquisition t ...19872824758
survey of nonhuman primates for antibodies reactive with epstein-barr virus (ebv) antigens and susceptibility of their lymphocytes for immortalization with ebv.the susceptibility to transformation with epstein-barr virus (ebv) and the prevalence of antibodies reactive to ebv were examined in 43 primate species. in vitro ebv infection was revealed in lymphocytes from old world monkeys, including patas monkeys and the colobines, as well as in lymphocytes from the apes. antibodies reactive to ebv-early antigen/viral capsid antigen (ea/vca) were detected in all the species of old world monkeys and apes examined and in two out of seven species of new world ...19872828628
immunization with vaccinia virus recombinants that express the surface glycoproteins of human parainfluenza virus type 3 (piv3) protects patas monkeys against piv3 infection.patas monkeys (eryphrocebus patas) were immunized intradermally with two vaccinia virus recombinants that individually express the hemagglutinin-neuraminidase glycoprotein or the fusion glycoprotein of human parainfluenza virus type 3 (piv3). these immunizations induced a high titer of piv3 serum-neutralizing antibodies. at 1 month after immunization, monkeys were challenged intratracheally with piv3. subsequent virus replication was reduced in these monkeys by 3.2 log10 and 1.9 log10 (mean peak ...19882831389
the effect of indoramin on plasma lipids in hypercholesterolemic patas patas monkeys fed a high cholesterol diet, chronic dosing with the antihypertensive agent indoramin increases the cholesterol ratio by raising the plasma hdl-c concentration. epidemiological evidence suggests that increasing hdl-c reduces the incidence of coronary heart disease (chd). if, therefore, indoramin is able to evoke these changes in man it may be expected to favourably influence the progress of chd.19852858569
different effects of epinephrine on the erythrocebus patas tracheal smooth muscle: predominance of alpha-adrenergic receptors. 19852866756
effects of phencyclidine, ketamine and mdma on complex operant behavior in one component of a multiple schedule, patas monkeys acquired a different four-response chain each session by responding sequentially on three levers in the presence of four numerals (acquisition). in the other component, the four-response chain was the same each session (performance). the response chain in each component was maintained by food presentation under a fixed-ratio schedule. after im administration, phencyclidine, ketamine, and mdma (3,4-methylenedioxymethamphetamine or "ecstasy") ...19872883665
invasive amebiasis in naturally infected new world and old world monkeys with and without clinical disease.histopathological preparations of cecum and colon from monkeys naturally infected with invasive entamoeba histolytica were examined to determine the distribution of amebae in the tissues and the types of lesions, if any, associated with them. infections were studied in 3 new world species (10 callicebus moloch, 1 c. torquatus, and 2 aotus trivirgatus) and 3 old world species (8 macaca mulatta, 6 erythrocebus patas, and 1 cercopithecus aethiops). amebiasis was recorded as the principal or a contr ...19882903689
concurrent infection of a patas monkey (erythrocebus patas) by citrobacter freundii and trichuris trichiura.concurrent infection of citrobacter freundii and trichuris trichiura in a patas monkey (erythrocebus patas) is reported. a synergistic effect of both organisms contributing to host mortality in this case is suggested.19892915394
delta-9-tetrahydrocannabinol potentiates the disruptive effects of phencyclidine on repeated acquisition in monkeys.patas monkeys acquired a different four-response chain each session by responding sequentially on three keys or levers in the presence of four discriminative stimuli (geometric forms or numerals). the response chain was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. each day there were four 15-min sessions, with a 10-min intersession interval. cumulative dose-effect curves for phencyclidine were obtained by giving an im ...19853001785
varicella-like herpesvirus infections of nonhuman least three distinct herpesviruses cause varicella like exanthematous diseases among nonhuman primates. spontaneous epizootics have resulted in high morbidity and mortality rates among cercopithecus aethiops, erythrocebus patas and macaca species in research colonies. mild infections have been observed in infant chimpanzees and a gorilla. this group of diseases is of interest not only because they are a threat to primate colonies, but also because their pathologic similarity to progressive hu ...19863007865
coxsackie virus b4 produces transient diabetes in nonhuman primates.cynomolgus, rhesus, and cebus monkeys failed to show glucose tolerance or insulin secretion abnormalities after infection with encephalomyocarditis virus or coxsackie virus b4. patas monkeys also showed no abnormalities after infection with encephalomyocarditis virus. however, patas monkeys infected with coxsackie virus b4 or treated first with a subdiabetogenic dose of streptozocin and then infected sequentially with coxsackie viruses b4 and b3 showed transient elevation of glucose tolerance te ...19863011574
uptake and development of wuchereria bancrofti in aedes aegypti and haitian culex quinquefasciatus that were fed on a monkey with low-density microfilaremia.colonized mosquitoes of culex quinquefasciatus (haitian strain) and aedes aegypti (liverpool strain) were blood fed on a patas monkey (erythrocebus patas) that had been experimentally infected with the haitian strain of wuchereria bancrofti and harbored a consistently low microfilaremia (1-3 mf per 20 mm3). both species ingested more than twice the expected number of microfilariae (mf), i.e. 1.9 and 0.77 mf per mosquito, respectively. however, at 10-16 hours post ingestion only 4.2% of the mf ha ...19883057592
evaluation in non-human primates of the safety, immunogenicity and efficacy of recombinant vaccinia viruses expressing the f or g glycoprotein of respiratory syncytial has been shown previously that immunization with recombinant vaccinia viruses expressing the f or g envelope glycoprotein of human respiratory syncytial virus (rsv) strain a2 induced a protective immune response in the lower respiratory tract of cotton rats against live rsv challenge. as a continuation of these studies, the safety, immunogenicity and efficacy of these recombinant vaccinia viruses was evaluated in non-human primates. rhesus and patas monkeys were each inoculated intradermally ...19883072795
biology and immunology of human strongyloidiasis.strongyloidiasis is an important human parasitic infection primarily because of its potential for serious and even lethal disease in immunosuppressed patients. certain features of the biology of strongyloides stercoralis, such as the ability to autoinfect the host, help explain why the parasite is dangerous. characteristics of the parasite can also be exploited in parasitological diagnosis of infection with the baermann concentration procedure and by culture. use of filariform larval antigens in ...19863081656
homologues of the human c and a apolipoproteins in the macaca fascicularis (cynomolgus) monkey.we used antisera to human a and c apolipoproteins to identify homologues of these proteins among the high-density lipoprotein apoproteins of macaca fascicularis (cynomolgus) monkeys, and nh2-terminal analysis was used to verify the homology. the nh2-terminal sequence of the m. fascicularis apoa-i is identical with that of another old world species, erythrocebus patas, and differs from human apoa-i at only 4 of the first 24 residues. m. fascicularis apoa-ii contains a serine for cysteine replacem ...19873105581
effect of ovariectomy on response to dietary cholesterol in patas monkeys (erythrocebus patas).from a group of 20 patas monkeys (erythrocebus patas), four high and four low responders to dietary cholesterol were selected for this study. the monkeys were paired according to their responsiveness to cholesterol, and ovariectomies were carried out on one group of the matched pairs. for the study, the monkeys were fed a prudent diet (at 0.1 mg cholesterol/cal) for 5 months preceding the ovariectomy and for 7 months after the ovariectomy followed by a rich diet (at 0.4 mg cholesterol/cal) for 7 ...19873111879
abolition of spontaneous rhythmic contractions of isolated monkey coronary arteries by diltiazem, nifedipine, verapamil and nicorandil but not by nitroglycerin.three of 12 coronary artery rings obtained from one of 9 rhesus monkeys (macaca mulatta) (113 rings in all) and 4 of 12 coronary artery rings obtained from one of 2 patas monkeys (erythrocebus patas patas) (28 rings in all) developed spontaneous rhythmic contractions. in 5 of these 7 coronary artery rings, rhythmic contractions occurred long enough to be subjected to examinations of drug effects. in these preparations the effects of the calcium entry blockers, diltiazem, nifedipine and verapamil ...19853157242
isolation and partial characterization of the low-molecular-mass zinc/cadmium-binding protein from the testes of the patas monkey (erythrocebus patas). distinction from metallothionein.the mammalian testes are generally quite susceptible to cadmium. a deficiency of metallothionein (mt), a metal-binding protein linked to cd tolerance, has been observed in rat testes and may explain the sensitivity in rats. little is known about the metal-binding proteins in primate testes. thus this study examined the nature of these proteins in a non-human primate species, the patas monkey (erythrocebus patas). in all cases proteins isolated from testes were compared with authentic mt isolated ...19883223896
edema resulting from experimental filariasis.domestic cats and patas monkeys were infected with brugia malayi so that the worms localized in the regional lymphatics of the hind legs. reaction to the filarial parasites resulted in visible local edema in cats and disruption of normal lymph flow in the monkeys. edematous tissue was examined grossly and by light and electron microscopy. lymph flow patterns were examined by direct observation following injection of lymph staining dye and reflection of the skin, by x-ray following injection of r ...19883236902
seed-eating by west african cercopithecines, with reference to the possible evolution of bilophodont on tooth use in eating fruits and seeds were collected on 12 west african monkeys representing five species of cercopithecines, cercopithecus aethiops, cercopithecus campbelli, cercocebus atys, erythrocebus patas, and papio papio. field observations and information in the published literature were used to select fruits for captive feeding trials. a total of over 27,000 tests were conducted to determine the preferences of the monkeys for 78 fruits. data were collected on the selection of fru ...19883364545
plantar depigmentation in patas monkeys. 19883367361
effects of changing hypothalamic temperature on eccrine sweating in the patas monkey.two male (10-13 kg) patas monkeys (erythrocebus patas) were implanted with bilateral thermodes to control hypothalamic temperature. animals were restrained in primate chairs and instrumented to yield hypothalamic (thypo), colonic (tc), and mean skin (tsk) temperatures, chest sweat rate (msw), and heart rate (hr). thypo was monitored using a thermocouple inserted to the tip of a non-perfused thermode; msw was measured using resistance hygrometry. after the monkey equilibrated to a selected ambien ...19883370501
effects of atropine and pyridostigmine in heat-stressed patas monkeys.the effects of a single intramuscular atropine injection (0.03 and a chronic oral pyridostigmine treatment (0.4, 3 times/day over a period of 7 d) on the thermoregulatory effector responses of unanesthetized patas monkeys were investigated using indirect calorimetry. the effects of atropine treatment on the thermoregulatory effector responses of patas monkeys exposed to 25 degrees and 35 degrees c were qualitatively similar but quantitatively greater at 35 degrees c. at 35 degre ...19883390112
[topography and structure of the stylohyoid muscle in mammals].topography and structure of the musculus stylohyoideus (msh) have been studied in 78 species of mammalia from 12 orders. the muscle in question has specific peculiarities not only in its position and fixation, but also in a great variability of its structure. the msh is not revealed in philander opossum, lagostrophus fasciatus, guinea pig, meriones eversmanni, rhombomys opimus, nyctereutes procyonoides, thos aureus, mastelidae. various pathways of development and different functional loading def ...19883408352
natural infections of vervet monkeys (cercopithecus aethiops) and african red monkeys (erythrocebus patas) in sudan with taeniid cysticerci. 19863503150
effects of changes in absolute signal level on psychophysical tuning curves in quiet and noise in patas monkeys.forward masking psychophysical tuning curves (ptcs) were measured in patas monkeys (erythrocebus patas) at 2, 4, and 8 khz at signal levels of 10, 30, and 60 db sl in quiet, and at 10 db above masked threshold in two levels of wideband noise. absolute signal levels with masking approximated those at 30 and 60 db sl in quiet. results in quiet agree with those reported in the literature, demonstrating broadening of the ptc as signal level is increased. the ptcs measured in noise also demonstrated ...19873624642
disposition and pharmacokinetics of meptazinol in the csf. studies after intrathecal administration in the non-human primate erythrocebus patas.a preliminary study is reported on the kinetics of meptazinol following intrathecal and i.m. administration in the patas monkey. following intrathecal administration (single dose of 0.5 mg) at t12/l1, meptazinol rapidly disappeared from the csf with a t1/2 of 35 min. at 240 min after intrathecal injection, most of the meptazinol had been distributed within the spinal tissue near the region of the injection, with minimal amounts reaching the brain (less than 5% of the concentrations present in th ...19873663435
nicotine can attenuate the disruptive effects of phencyclidine on repeated acquisition in monkeys.patas monkeys acquired a different four-response chain each session by responding sequentially on three levers in the presence of four discriminative stimuli (numerals). the response chain was maintained by food presentation under a fixed-ratio schedule. errors produced a brief timeout but did not reset the chain. each day there were four 15-min sessions, with a 10-min intersession interval. cumulative dose-effect curves for phencyclidine were obtained by giving an im injection before each of th ...19863749226
repeated acquisition and delayed performance as a baseline to assess drug effects on retention in an extension of previous research on repeated acquisition, a new baseline was developed to assess the effects of phencyclidine on retention in patas monkeys. each session was divided into three phases: acquisition, delay, and performance. during acquisition, the subject acquired a four-response chain (which was different each session) by responding sequentially on three keys in the presence of four geometric forms. when the acquisition criterion (20 consecutive correct responses) was met, the ...19863749227
effects of mixed agonist-antagonist opioids on the acquisition of conditional discriminations in monkeys.responding in patas monkeys was maintained under a multiple schedule of food presentation. one component of the multiple schedule was a repeated-acquisition task in which the discriminative stimuli for left- and right-key responses changed each session (learning). in the other component, the discriminative stimuli were the same each session (performance). the mixed agonist-antagonists dezocine, gpa 1657 and nalbuphine each produced dose-related decreases in the overall rate of responding in each ...19873806399
loa loa: development and course of patency in experimentally-infected primates.loa loa infections were studied in baboons, rhesus and patas monkeys. animals were infected either by s.c. injection of third-stage larvae (l 3) or by surgical implantation of juvenile worms of known age, sex and number. microfilaremia was first detected in baboons at 140 days following inoculation of l 3 and at 142 days and 143 days in patas and rhesus monkeys, respectively; the mean prepatent period was 151 days in baboons, 149 days in patas monkeys and 169 days in rhesus monkeys. the primary ...19853867108
endocrine profile of pregnancy in the patas monkey (erythrocebus patas).spontaneous toxemia occurs in approximately 6% of pregnancies in patas monkeys (erythrocebus patas). to assess further the relevance of this animal as a model system for toxemia of pregnancy in humans, we characterized the endocrine profile of the patas pregnancy by analyzing weekly blood samples for estrone, estradiol, estriol, progesterone, aldosterone, and pra throughout gestation. the profiles obtained bear striking resemblance to those described for human pregnancy, an unexpected finding si ...19853882395
fibrinopeptides a and b of japanese monkey (macaca fuscata) and patas monkey (erythrocebus patas): their amino acid sequences, restricted mutations, and a molecular phylogeny for macaques, guenons, and baboons.amino acid sequences of fibrinopeptides a and b from the macaque, macaca fuscata (japanese monkey) and the guenon, erythrocebus patas (patas monkey) were established. fibrinopeptides a of the monkeys had a sequence identical with those of baboons: ala-asp-thr-gly-glu-gly-asp-phe-leu-ala-glu-gly-gly-gly-val-arg. fibrinopeptides b were 9-residue, "short," peptides with the sequences asn-glu-glu-ser-leu-phe-ser-gly-arg for m. fuscata and asn-glu-glu-val-leu-phe-gly-gly-arg for e. patas. the sequenc ...19853928610
differences among isolates of simian hemorrhagic fever (shf) virus.simian hemorrhagic fever (shf) virus is a member of the togaviridae family which currently is unclassified to genus. we have studied the relatedness of four different shf virus isolates obtained from infected macaque or patas monkeys. differences were found among isolates in type and severity of disease produced in patas monkeys, cell sensitivity to infection, viral antigens, and levels of specific antibody induced in patas monkeys. based on these criteria, the four isolates have been grouped in ...19863945613
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