Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the vampire bat. | 1931 | 17802361 | |
| observations on the vampire bat with special reference to longevity in captivity. | 1946 | 20996664 | |
| derriengue; vampire bat rabies in mexico. | 1948 | 18908914 | |
| reproduction and the female reproductive cycle in the tropical american vampire bat, desmodus rotundus murinus. | 1952 | 12996445 | |
| the fetal membranes and placentation of the tropical american vampire bat desmodus rotundus murinus, with notes on the histochemistry of the placenta. | 1954 | 13196828 | |
| vampire bat as a carrier of rabies. | 1954 | 13171471 | |
| rabies in cattle. v. immunization of cattle in brazil against exposure to street virus of vampire bat origin. | 1955 | 13263234 | |
| rabies in the vampire bat of trinidad, with special reference to the clinical course and the latency of infection. | 1959 | 14431118 | |
| the transmission of paralytic rabies in trinidad by the vampire bat (desmodus rotundus murinus wagner. | 1959 | 13858519 | |
| anatomy and histochemistry of the salivary glands of the vampire bat, desmodus rotundus murinus. | 1960 | 13723067 | |
| plasminogen activator in saliva of the vampire bat desmodus rotundus. | 1966 | 5967844 | |
| [on the isolation in brazilof rabies virus from the lung, heart and various other tissues of hematophagous vampire bats belonging to the species desmodus rotundus]. | 1966 | 6011926 | |
| inhibitor of platelet aggregation present in saliva of the vampire bat desmodus rotundus. | 1967 | 6075437 | |
| body temperature, oxygen consumption and heart rate in the australian false vampire bat, macroderma gigas. | 1967 | 6033844 | |
| the allantoic placenta of the vampire bat (desmodus rotundus murinus): a reinterpretation of its structure based on electron microscopic observations. | 1968 | 5748799 | |
| quantitative data on the inferior olivary nucleus in man, cat and vampire bat. | 1968 | 5657523 | |
| [portable vampire bat trap for use in rabies control programs]. | 1969 | 4247639 | |
| activation of the blood fibrinolytic mechanism in birds by saliva of the vampire bat (diaemus youngi). | 1969 | 5773575 | |
| the vampire bat (desmodus rotundus): improved methods of laboratory care and handling. | 1970 | 5527818 | |
| vampire-bat transmitted rabies virus from surinam. comparison of properties with european street virus and fixed virus. | 1970 | 4908047 | |
| [structural aspects of mossy fibers. comparative study: cavia cobaya and desmodus rotundus. golgi's method and electron microscopy]. | 1970 | 5525395 | |
| movement and population studies of the vampire bat (desmodus rotundus) in mexico. | 1971 | 5545561 | |
| epidemic strain of venezuelan equine encephalomyelitis virus from a vampire bat captured in oaxaca, mexico, 1970. | a vampire bat, desmodus rotundus, captured in oaxaca, mexico, in august 1970, was found to be infected with the epidemic strain of venezuelan equine encephalomyelitis virus at the same time that an equine epizootic was occurring there. | 1972 | 5008598 |
| vampire bat control by systemic treatment of livestock with an anticoagulant. | the blood of beef cattle given single doses (1 milligram per kilogram of body weight) of diphenadione (2-diphenylacetyl-1,3-indandione) became toxic to vampire bats (desmodus rotundus) and remained toxic for 3 days without harming the cattle. cattle at three ranches in mexico treated with single intraruminal injections of diphenadione experienced a reduction in vampire bat bites of 93 percent. bioassays of milk and liver from cattle treated orally with diphenadione in the laboratory indicated th ... | 1972 | 5068491 |
| [characteristics of a rabies virus strain isolated from the brain of desmodus rotundus]. | 1972 | 4262443 | |
| an unusual relationship between glial cells and neuronal dendrites in olfactory bulbs of desmodus rotundus. | 1972 | 5009644 | |
| food temperature preference response of desmodus rotundus. | 1973 | 4705265 | |
| ovulation and early embryonic development in the captive vampire bat, desmodus rotundus. | 1974 | 4452969 | |
| the plasminogen activator of vampire bat saliva. | 1974 | 4204546 | |
| vampire bat control in the americas; a review and proposed program for action. | 1974 | 4421502 | |
| control of bovine rabies through vampire bat control. | 1974 | 4436917 | |
| letter: disappearance of trypanosoma evansi from a vampire bat colony in western colombia. | 1974 | 4818671 | |
| presence of rabies neutralizing antibodies in wild carnivores following an outbreak of bovine rabies. | in an outbreak of bovine rabies in argentina, a study was made of vampire bats (desmodus rotundus) and wild carnivores. rabies antibody rates of high prevalence were found in the bats, foxes (dusicyon gymnocercus) and skunks (conepatus chinga). the outbreak was part of an extensive continuing epizootic of vampire transmitted bovine rabies which may have also involved other vectors in the area of this study. consumption of dead and dying bats by the carnivores is the suggested means of passage of ... | 1975 | 1142554 |
| observations on the epizootiology of vampire bat rabies. | vampire bat populations were opportunely sampled before, during, and at varying intervals after outbreaks of bovine rabies. the captured bats were examined for rabies neutralizing antibody and virus. in all, sera from 1,024 vampire bats were tested for antibody, and tissues from these bats plus 83 others were tested for virus. neutralizing antibody only rarely appeared in vampire serum samples taken before bovine rabies outbreaks, and only low percentages of samples positive for rabies antibody ... | 1975 | 1212534 |
| [isolation of rabies virus from brain, salivary and interscapular glands, heart, lungs and testis of the bat desmodus rotundus, in the state of são paulo (author's transl)]. | rabies virus was isolated from the brain, salivary and interscapular (brown fat) glands, heart, lungs and testis of naturally infected vampire bat desmodus rotundus found paralyzed in the day at barueri, são paulo state. the rabies virus isolations were made by intracerebral inoculation in 4-5 days and 30 days old mice. the virus strain was identified as rabies virus by the sellers and faraco (mann) techniques, the fluorescent antibody test and intracerebral inoculation of mice. the isolation of ... | 1975 | 1236047 |
| [bacteriological study of the intestinal flora of bats (desmodus rotundus) (author's transl)]. | stools of 100 bats trapped in the town of anhembi, state os são paulo, brazil, were examined bacteriologically. hemolityc and non hemolytic strains of escherichia coli were found most frequently (29.5%) followed by proteus group (27%) and staphylococcus (20%). from nine samples of stools the authors isolated salmonella typhimurium. | 1975 | 1236052 |
| anti-brucella agglutinins in bats and "callithrix" monkeys. | anti-brucella agglutinins were found in 5 of 53 (9.4%) vampire bats desmodus rotundus, captured in the state of bahia, brasil. two specimens of diphylla ecaudata were negative. fifty specimens of the small monkey, callithrix penicillata, were also negative. | 1976 | 815569 |
| a method for bleeding vampire bats, desmodus rotundus murinus. | 1976 | 940316 | |
| echolocation performance of the vampire bat (desmodus rotundus). | the neotropical vampire bats (desmodus rotundus) echolocate using ultrasonic pulses like those of the latin american phyllostomatid bats. in this paper the orally produced echolocation sounds of desmodus are analysed and the performance of the echolocation system is studied in two-choice training experiments on two vampire bats. ability to detect objects is relatively limited; both animals were capable of discerning the presence of a 1 cm wide metal strip at a distance of 50 cm, but they failed ... | 1977 | 610226 |
| isolation of rabies virus from bats in bolivia. | rabies virus was isolated from apparently normal blood-sucking (desmodus rotundus) and insectivorous (artibeus planirostris) bats caught in bolivia. the virus was identified by immunofluorescence, biological and sero-neutralisation tests. | 1978 | 664008 |
| serological evidence of infection of tacaribe virus and arboviruses in trinidadian bats. | sera from 39 species of bats collected in trinidad between 1972 and 1974 were tested against some or all of 18 arboviruses in hemagglutination inhibition (hi) and/or suckling mouse neutralization (n) tests. a few sera were hi-positive with mucambo, eastern equine encephalitis (eee), oriboca, restan, manzanilla, guama, bimiti, and catu. no sera were hi-positive with mayaro, caraparu or maguari. many ser inhibited one or more of the group b hemagglutinins: ilheus, st. louis encephalitis (sle), den ... | 1978 | 204207 |
| electrical response of bat retina to spectral stimulation: comparison of four microhiropteran species. | electrical responses of the retinas of 4 species of microchiropteran bats stimulated by spectrally restricted light flashes were found to diverge systematically from the rhodopsin absorption spectrum. the divergence was progressively greater across the 4 species. the results appeared explainable by assuming a second photoreceptor class and photopigment which was present in progressively greater numbers in the retinas of eptesicus fuscus, desmodus rotundus, artibeus jamaicensis and carollia persp ... | 1979 | 488274 |
| [a note on the stomach of the vampire bat (desmodus rotundus) (author's transl)]. | 1979 | 463494 | |
| [enterobacteria of bats (chiroptera) (author's transl)]. | the aerobic gram-negative faecal flora of 38 bats consisting of 10 species and genera respectively, of microchiroptera, and of 4 species and genera respectively, of megachiroptera was studied (table 1 and 3). there were no specific differences between insectivora and frugivora: e. coli 15-24%, citrobacter 8-10%, enterobacter-klebsiella-group 40-43% and proteus-group 28-30% (table 2). the overwhelming majority of the isolated bacteria were lactose-positive (table 3), corresponding to the membersh ... | 1980 | 7424248 |
| adaptation, attenuation and plaque purification of a rabiesvirus isolate (v319) from a vampire bat (desmodus rotundus). | five rabiesvirus isolates, four of vampire bat origin and one from the brain of a rabid cow, were studied with respect to their adaptability to tissue culture. only two strains (v319 and mazatan strains) adapted readily. one (mazatan) failed to yield high titers in vitro after isolation, plaque purification and further passage; however, the v319 strain routinely yielded titers of 10(9) pfu/ml. in limited pathogenicity tests in cattle and dogs, the v319 strain was found not to be excreted in the ... | 1980 | 7428375 |
| experimental rabies in the vampire bat. | vampire bats were inoculated intramuscularly and subcutaneously with varying doses of rabies virus to simulate bites by rabid animals in nature. daily saliva samples were then taken from these animals to determine whether they excreted virus and for how long. vampire bats appear to react to rabies virus as do other animals, with variable incubation periods, some excretion of virus in the saliva, but no prolonged excretion "carrier state." | 1980 | 7369444 |
| distribution of iron in the gastrointestinal tract of the common vampire bat: evidence for macrophage-linked iron clearance. | iron in the tissues of the digestive tract of the common vampire bat (desmodus rotundus) has been studied using histochemical, electron microscopic, and autoradiographic methods. this animal is an obligate sanguivore and has a daily intake of dietary iron 800 times that of man. the amount and distribution of tissue iron is not affected by either a single blood meal or starvation but does reflect the degree of siderosis of each animal's liver and spleen. by 7 days after the injection of a trace a ... | 1980 | 7212303 |
| [aeromonas hydrophila as a normal intestinal bacterium of the vampire bat (desmodus rotundus)]. | 1980 | 7053178 | |
| vampire bat bites seen in humans in panama: their characterization, recognition, and management. | 1981 | 6787469 | |
| taste preferences of the common vampire bat (desmodus rotundus). | taste preference tests, with simultaneous presentation of treated and untreated food, were administered to 24 common vampire bats (desmodus rotundus). the bats received brief exposures to four different stimuli representing sweet, salty, sour, and bitter tastes, each at four different concentrations. despite a strong location bias, the bats significantly (p < 0.01) avoided the highest concentrations of the salty, sour, and bitter tastes. consumption of the sweet stimulus at all concentrations wa ... | 1982 | 24415119 |
| fine structure of the vomeronasal neuroepithelium of bats: a comparative study. | the vomeronasal neuroepithelium of the vampire bat, desmodus rotundus, and the frugivorous bats, carollia perspicillata and artibeus jamaicensis, was examined at the light-microscopic and ultrastructural levels. the neuroepithelium of these species is basically similar in morphology to that of other mammals. however, hitherto unknown differences were noted in regard to the configuration of the apical poles of cells, in the occurrence of solitary cilia, dislocated sensory cells, brush cells, cell ... | 1982 | 7102243 |
| iron balance in the common vampire bat desmodus rotundus. | 1. total body iron in the common vampire bat was 80 +/- 67 mg fe/kg body wt (mean +/- sd). 2. mean (+/- sd) iron absorption as measured by the double isotope method was 0.068 +/- 0.0032% fe. a typical adult bat ingests 6.1 mg fe/day (morton & wimsatt, 1980) of which approximately 4.2 microgram fe is absorbed. 3. body iron turnover (bit) was estimated from the decrease in specific radioactivity of the blood over more than a year. the mean (+/- sd) of the half-life of iron turnover was 379 +/- 101 ... | 1982 | 6128125 |
| a plaque-purified rabies virus (strains v-319) derived from a vampire bat (desmodus rotundus) in mexico: vaccine potential. | a plaque-purified experimental rabies vaccine was developed from an isolate (strain v-319) made from a naturally infected vampire bat (desmodus rotundus). two different vaccines were prepared; one was live virus and the second was an inactivated rabies virus preparation. the live virus vaccine, as well as a betapropiolactone-inactivated vaccine, gave complete protection to challenge inoculation after 1 year. in contrast, greater than 80% of the non-vaccinated experimental control cattle died of ... | 1984 | 6467947 |
| a suspected infrared-recipient nucleus in the brainstem of the vampire bat, desmodus rotundus. | we discovered in the brainstem of infrared-sensitive vampire bats, desmodus rotundus, a specific nucleus not known in other species of bats. because it corresponded in location and histological features to the infrared nucleus of infrared-sensitive snakes, we suggest the probability of its being part of the infrared processing system of vampire bats. | 1984 | 6509324 |
| warm and cold receptors in the nose of the vampire bat desmodus rotundus. | 1984 | 6472483 | |
| immunocytochemical study of gastro-entero-pancreatic (gep) endocrine cells in the vampire bat (desmodos rotundus). | the distribution and frequency of gastro-entero-pancreatic (gep) endocrine cells were studied in vampire bats by immunocytochemistry. moderate numbers of somatostatin- and a few 5-hydroxytryptamine (5-ht)- and glucagon-immunoreactive cells were seen in the fundic cecum of the stomach. numerous gastrin- and moderate numbers of somatostatin- and 5-ht-immunoreactive cells were found in the pyloric region. moderate numbers of 5-ht-, somatostatin-, and gastrin-immunoreactive cells also were found in ... | 1984 | 6152240 |
| cross protection of mice against different rabies virus isolates. | in an attempt to identify "atypical" strains which could account for vaccination failures, 10 street, one intermediate (dr19) and 4 fixed rabies virus isolates from men, cattle, dogs, cats, mongoose and vampire bats in five countries (argentina, brazil, chile, cuba, and france) were studied by cross-protection tests in mice. for the purpose of this study, any virus that killed more than 20% of the vaccinated mice challenged with that virus was considered "atypical". when the suckling mouse brain ... | 1985 | 2409716 |
| visual acuity of the vampire bat, desmodus rotundus, and its dependence upon light intensity. | the visual system of microchiropteran bats is usually considered of minor function, but reliable experimental studies are rare. in this paper the visual acuity of three (1 female, 2 male male) vampire bats (desmodus rotundus) has been investigated in a two-choice training apparatus (striped patterns vs. gray patterns) for light intensities from 0.04 1x to 310 1x. there was a logarithmic dependence between light intensity and visual acuity. the lowest visual angle at 0.04 1x was 2 degrees 31', at ... | 1986 | 1007656 |
| plasma sex steroid binding in chiroptera. | plasma steroid binding was examined in samples obtained from seven species of bats representing four different families. a specific sex steroid-binding protein (sbp) was identified by steady-state polyacrylamide gel electrophoresis in representatives of two families, the phyllostomids and the vespertilionids. in these species, as in primates, sbp not only exhibited high affinity for the androgens testosterone and dihydrotestosterone (dht), but also for estradiol. a specific sbp was not identifie ... | 1987 | 3593835 |
| ultrastructure of the pineal body of the common vampire bat, desmodus rotundus. | the type ab pineal body of the common vampire bat, desmodus rotundus, was recessed and lobulated, was extensively vascularized and intimately related to great veins, and was unassociated with the epithalamic region. the habenular and the posterior commissures coursed anteriorly and were unassociated with the pineal. the saccular suprapineal recess of the third ventricle extended dorsally juxtaposed to the pineal body. these anatomical features are likely to make pinealectomies in the vampire mor ... | 1988 | 3369358 |
| consumption of blood, renal function and utilization of free water by the vampire bat, desmodus rotundus. | 1. captive vampires consume blood to an average of 59.5% of their body weight in a period no longer than 30 min. 2. fluid consumption by the vampire is mainly dependent on the presence of plasma in fluid. 3. ingestion of blood is accompanied and followed by diuresis, urine flow attained a peak 20-25 min after feeding. 4. urine osmolality increased with time after feeding. vampires concentrate urea in urine to 2630 mmol/l but cannot concentrate electrolytes beyond 453 mmol/l. 5. inorganic salts o ... | 1988 | 2900098 |
| analysis of cold and warm receptor activity in vampire bats and mice. | the response characteristics of facial thermoreceptors of the common vampire bat and of the mouse have been quantitatively studied. cold receptors were identified in bat and mouse; warm receptors were only established in the bat. cold and warm receptor populations of the two species share most of their properties with facial thermoreceptor populations of various mammalian species investigated so far. the temporal pattern of activity of cold receptors of the mouse corresponded to that observed in ... | 1988 | 3174381 |
| biology, ecology, and control of the vampire bat. | the importance of the vampire bat as a vector of rabies and its taxonomy, anatomic characteristics, distribution, feeding habits, behavior, and habitat are described. also described are studies of methods of reducing vampire bat populations. anticoagulants such as diphenadione and warfarin were shown to be effective in reducing vampire bat populations. these substances were used in different ways: application of the compound to the skin of captured vampires and then the release of the animals to ... | 1988 | 3060955 |
| vampire bat-transmitted rabies in cattle. | a short history of bovine paralytic rabies in the americas is given. based on information from the animal health yearbook--a cooperative publication of the food and agriculture organization (fao), the world health organization (who), and the international office of epizootics (oie)--a comparison is made of the epidemiology of the disease in 1968, 1978, and 1985. an important reduction in the number of cases of rabies was observed in some countries (bolivia, brazil, guatemala, mexico, nicaragua, ... | 1988 | 3206085 |
| adult phyllostomid (bat) enamel by scanning electron microscopy--with a note on dermopteran enamel. | this study assesses the enamel of five phyllostomids of differing feeding habits; only one example of the microchiropteran super-family phyllostomoidae having previously been studied by sem. a dermopteran was also examined to ascertain whether the enamel might reveal insectivore, chiropteran or primate characteristics. the five phyllostomids were found to display the additional crystallite discontinuity feature (minor boundary plane or seam) which is a major characteristic of all the bats we hav ... | 1988 | 3368766 |
| spinturnicid mites (gamasida: spinturnicidae) associated with bats in central brazil. | the results of a survey of spinturnicid mites (gamasida: spinturnicidae) infesting bats near brasília, d.f., brazil, are presented. one hundred twenty-five bats were collected, representing three families and 15 species. seven species of spinturnicid mites (genus periglischrus) were collected from nine species of bats (family phyllostomidae). each of the following six species of periglischrus was associated with a single species of bat: periglischrus acutisternus machado-allison and p. torrealba ... | 1989 | 2795621 |
| human depredation by vampire bats (desmodus rotundus) following a hog cholera campaign. | hog cholera control efforts in belize in 1975 included the slaughter of village pigs, a primary food source for the vampire bat (desmodus rotundus). the bats then fed on secondary food sources, including humans. in 1 village, 22% of the families interviewed were exposed to attacks: 17 children and 2 adults were bit. human depredation was not continuous as desmodus located other hosts. | 1989 | 2929856 |
| isolation, characterization, and cdna cloning of a vampire bat salivary plasminogen activator. | vampire bat saliva contains a plasminogen activator that presumably assists these hematophagous animals during feeding. here, we report that the vampire bat salivary plasminogen activator, bat-pa, is homologous to tissue-type plasminogen activator (t-pa) but contains neither a kringle 2 domain nor a plasmin-sensitive processing site. three bat-pa species corresponding to full-length, finger-, and finger- epidermal growth factor homology domain- forms of t-pa have been isolated. bat-pa(h), the fu ... | 1989 | 2509450 |
| fine structure of the boundary tissue of the seminiferous tubuli of the vampire bat (desmodus rotundus, g.; microchiroptera). | structurally the boundary tissue of the vampire bat seminiferous tubuli showed 2 to 5 layers of connective tissue in which elongated contractile cells and lamellar and/or fibrillar collagen were noticed. this boundary tissue forms the seminiferous tubular lamina propria. its structure was more complex around the seminiferous tubuli near the capsula testicularis than between the adjacent and contiguous tubuli into the testicular lobuli. the whole ultrastructural organization of the seminiferous l ... | 1990 | 2318392 |
| [histochemical and structural characteristics of the testis of the vampire bat (desmodus rotundus rotundus, geoffrey, 1810)]. | the testicular stroma of the vampire bat including the testicular capsula and the lamina propria of the seminiferous tubuli, was strongly pas-positive. this observation was a possible indication of great amounts of structural glycogen and other glycoconjugates at the level of smooth muscle cells; elongated contractile cells and/or collagen frameworks of the tunica albuginea and tubular lamina propria. in the last the basement membranes of the seminiferous tubules were particularly strongly pas p ... | 1990 | 2089486 |
| ultrastructure of the principal and accessory submandibular glands of the common vampire bat. | the principal and accessory submandibular glands of the common vampire bat, desmodus rotundus, were examined by electron microscopy. the secretory endpieces of the principal gland consist of serous tubules capped at their blind ends by mucous acini. the substructure of the mucous droplets and of the serous granules varies according to the mode of specimen preparation. with ferrocyanide-reduced osmium postfixation, the mucous droplets are moderately dense and homogeneous; the serous granules ofte ... | 1990 | 2285039 |
| vampire bat salivary plasminogen activator is quiescent in human plasma in the absence of fibrin unlike human tissue plasminogen activator. | the vampire bat salivary plasminogen activator (bat-pa) is a potent pa that exhibits remarkable selectivity toward fibrin-bound plasminogen (gardell et al, j biol chem 256: 3568, 1989). herein, we describe the activity of recombinant dna-derived bat-pa (rbat-pa) in a human plasma milieu. rbat-pa and recombinant human single-chain tissue plasminogen activator (rt-pa) are similarly efficacious at lysing plasma clots. in stark contrast to rt-pa, the addition of 250 nmol/l rbat-pa to plasma in the a ... | 1990 | 2124935 |
| the plasminogen activator family from the salivary gland of the vampire bat desmodus rotundus: cloning and expression. | complementary dnas coding for four desmodus rotundus salivary plasminogen activators (dspas) were isolated and characterized. the predicted amino acid sequences display structural features also found in tissue-type plasminogen activator. the largest forms (dspa alpha 1 and -alpha 2) contain a signal peptide, a finger (f), an epidermal growth factor (egf), a kringle, and a serine protease domain, whereas dspa beta and -gamma lack the f and f-egf domains, respectively. additional differences betwe ... | 1991 | 1937019 |
| effective thrombolysis without marked plasminemia after bolus intravenous administration of vampire bat salivary plasminogen activator in rabbits. | the use of recombinant tissue-type plasminogen activator (t-pa) in thrombolytic therapy is frequently associated with significant fibrinogenolysis. in contrast, recombinant vampire bat salivary plasminogen activator (bat-pa) displays strict fibrin specificity, an attribute that could be desirable in a fibrinolytic agent. | 1991 | 1905593 |
| plasminogen activators from the saliva of desmodus rotundus (common vampire bat): unique fibrin specificity. | the saliva of d. rotundus contains at least four plasminogen activators (pas) which all require fibrin as a cofactor. d. rotundus salivary pas (dspas) exhibit a sequential array of structural motifs such as "finger" (f), "egf" (e), "kringle" (k) and "protease" (p) which was elucidated by cdna cloning and sequencing. the respective domain organizations are: fekp (dspa alpha 1 and dspa alpha 2), ekp (dspa beta) and kp (dspa gamma). in all four forms the plasmin-sensitive site of tpa is obliterated ... | 1992 | 1309059 |
| outbreak of human rabies in the peruvian jungle. | transmission of rabies to man by vampire bats has been known for 60 years but there have been few reports of the features of rabies transmitted in this way. these aspects of the disease were investigated during an outbreak in peru in early 1990. between jan 1 and april 30, 1990, 29 (5%) of 636 residents of the two rural communities in the amazon jungle in peru acquired an illness characterised by hydrophobia, fever, and headache and died shortly thereafter. a census in one of the two towns revea ... | 1992 | 1346669 |
| vampire bat salivary plasminogen activator promotes rapid and sustained reperfusion without concomitant systemic plasminogen activation in a canine model of arterial thrombosis. | the efficacy of recombinant vampire bat salivary plasminogen activator (bat-pa) as a thrombolytic agent was compared with that of human tissue-type plasminogen activator (t-pa) in a canine model of arterial thrombosis. an occlusive thrombus was formed in the femoral artery by insertion of a thrombogenic copper coil; femoral arterial blood flow was monitored with a doppler flow meter. bat-pa and t-pa, when administered by 5-minute intravenous infusion (14 nmol/kg), reperfused seven out of eight a ... | 1992 | 1371932 |
| vampire bat salivary plasminogen activator exhibits a strict and fastidious requirement for polymeric fibrin as its cofactor, unlike human tissue-type plasminogen activator. a kinetic analysis. | the vampire bat salivary plasminogen activator (batpa) is virtually inactive toward glu-plasminogen in the absence of a fibrin-like cofactor, unlike human tissue-type plasminogen activator (tpa) (the kcat/km values were 4 and 470 m-1 s-1, respectively). in the presence of fibrin ii, tpa and batpa activated glu-plasminogen with comparable catalytic efficiencies (158,000 and 174,000 m-1 s-1, respectively). batpa's cofactor requirement was partially satisfied by polymeric fibrin i (54,000 m-1 s-1), ... | 1992 | 1387641 |
| vampire bat salivary plasminogen activator promotes robust lysis of plasma clots in a plasma milieu without causing fluid phase plasminogen activation. | vampire bat salivary plasminogen activator (batpa), human tissue-type plasminogen activator (tpa) or streptokinase (sk) were incubated in human citrated plasma containing a plasma clot that was radiolabelled with iodine-125 fibrin(ogen). complete clot dissolution by batpa (30 nm) was associated with slight activation of "fluid phase" plasminogen; the plasma levels of functional fibrinogen and alpha 2-antiplasmin decreased by only 8 and 19%, respectively. addition of sk (3,600 iu/ml) to the clot- ... | 1992 | 1412162 |
| thrombolytic properties of desmodus rotundus (vampire bat) salivary plasminogen activator in experimental pulmonary embolism in rats. | rdspa alpha 1 (recombinant desmodus salivary plasminogen activator alpha 1) is a recombinant protein corresponding to a natural plasminogen activator from the vampire bat desmodus rotundus. the thrombolytic properties of rdspa alpha 1 and tissue-type plasminogen activator (t-pa) were compared in a rat model of pulmonary embolism. whole blood clots, produced in vitro and labeled with 125i-fibrinogen, were embolized into the lungs of anesthetized rats. thrombolysis was calculated from the differen ... | 1992 | 1536947 |
| seasonal reproduction of vampire bats and its relation to seasonality of bovine rabies. | studies of pregnancy and lactation in vampire bats (desmodus rotundus) in northern argentina over a 4 yr period showed an inverse relationship between prevalence of pregnancy and lactation, the consequence of birth and onset of lactation, which was correlated with the wet season. the seasonal influx of young susceptibles into the vampire population in the wet season coincided with the well known increase in vampire transmitted rabies in that season. | 1992 | 1602584 |
| high-level secretion of the four salivary plasminogen activators from the vampire bat desmodus rotundus by stably transfected baby hamster kidney cells. | the cdnas coding for the four desmodus rotundus salivary plasminogen activators (dspas) were subcloned into the mammalian expression vector, pmpsv/cmv, which carries the myeloproliferative sarcoma virus promoter and the cytomegalovirus enhancer. these constructs were transfected, together with plasmids harbouring geneticin (g418)-resistance and puromycin-resistance genes, into baby hamster kidney cells. through the selective pressure of both antibiotics, cell clones constitutively overexpressing ... | 1992 | 1634121 |
| an outbreak of vampire bat bite in a brazilian village. | an outbreak of 26 cases of vampire bat bite in one month in the rural area of honorópolis, a brazilian village, is reported. all patients were bitten during the night, when they were asleep, and most bites were on their toes. no complication attributed to the bite was reported. the patients were given prophylactic antirabies serum and rabies vaccine. control of the outbreak was achieved by visiting bat roosting sites, smearing captured vampire bats (desmodus rotundus) with a paste of 2% warfarin ... | 1993 | 8256101 |
| histochemical and myosin composition of vampire bat (desmodus rotundus) pectoralis muscle targets a unique locomotory niche. | the vampire bat pectoralis muscle contains at least four fiber types distributed in a nonhomogeneous pattern. one of these fiber types, here termed iie, can be elucidated only by adenosine triphosphatase (atpase) histochemistry combined with reactions against antifast and antislow myosin antibodies. the histochemical and immunohistochemical observations indicate a well-developed specialization of function within specific regions of the muscle. in parallel, analyses of native myosin isoforms and ... | 1993 | 8230235 |
| [ultrastructural characteristics of sertoli cells of the vampire bat (desmodus rotundus rotundus, geoffrey, 1810)]. | this paper deals with the ultrastructural study of mature vampire bat sertoli cells and their relationships with the different stages of testicular germ cells. in vampire bat seminiferous epithelium there are different types of junctional specializations among sertoli cells and among sertoli cells and different germ cells, with special emphasis to tight junctions and to junctions like as desmosomes. ectoplasmic junctions through the sertoli cells, including the smooth er, are observed. these cel ... | 1993 | 8209033 |
| vampire bat salivary plasminogen activator. | 1993 | 8271956 | |
| the search for the ideal thrombolytic agent: maximize the benefit and minimize the risk. | streptokinase, acylated plasminogen streptokinase complex, and tissue-type plasminogen activator (tpa) are widely used for the treatment of acute myocardial infarction. these thrombolytic agents restore blood flow in occluded coronary arteries, salvage myocardial function, and decrease mortality. the success of thrombolytic therapy depends on the prompt and stable recanalization of the occluded blood vessel. hemorrhagic events undermine the safety of fibrinolytic agents. most bleeding complicati ... | 1993 | 8210941 |
| coronary thrombolysis with desmodus salivary plasminogen activator in dogs. fast and persistent recanalization by intravenous bolus administration. | dspa (desmodus salivary plasminogen activator) is a new thrombolytic agent corresponding to a natural plasminogen activator discovered in the saliva of the vampire bat desmodus rotundus. compared with tissue plasminogen activator (tpa), dspa, produced in a recombinant cell line, is more fibrin cofactor dependent than tpa. | 1994 | 8026028 |
| fibrinolytic agents: mechanisms of activity and pharmacology. | fibrinolytic (thrombolytic) agents activate the fibrinolytic system by conversion of the inactive proenzyme, plasminogen into the active enzyme plasmin, that degrades fibrin. agents available for clinical use are: the physiologic tissue-type plasminogen activator (t-pa) and urokinase-type plasminogen activator (u-pa)--either in a single chain (scu-pa, prourokinase) or a two-chain (tcu-pa, urokinase) form, and the bacterial activator plasminogen streptokinase or its anisoylated complex with plasm ... | 1995 | 8578491 |
| generation of monoclonal antibodies against autologous proteins in gene-inactivated mice. | induction of an immune response is strongly dependent on the phylogenetic distance between antigen and recipient. in general, antibodies will not be raised against self-antigens nor against highly conserved domains. in the present study we describe the production and characterization of murine monoclonal "auto-antibodies" against murine tissue-type plasminogen activator (t-pa) raised in "knock-out" mice, homozygously deficient of the functional gene. 203 stable hybridomas were obtained producing ... | 1995 | 7536737 |
| comparison of the bleeding potential of vampire bat salivary plasminogen activator versus tissue plasminogen activator in an experimental rabbit model. | vampire bat salivary plasminogen activator (bat-pa) has significantly greater fibrin specificity than any of the fibrinolytic agents currently in clinical use. this study tests the hypothesis that avoiding fibrinogen depletion may protect against the hemorrhage induced by plasminogen activator treatment. | 1995 | 7867196 |
| vampire bat salivary plasminogen activator evokes minimal bleeding relative to tissue-type plasminogen activator as assessed by a rabbit cuticle bleeding time model. | cuticle bleeding time (cbt) measurements in anesthetized rabbits were performed to assess the potential bleeding risks which may accompany the administration of tissue-type plasminogen activator (tpa) or vampire bat salivary plasminogen activator (batpa). the dose of batpa or tpa used in this study, 42 nmol/kg, was previously shown to be efficacious using a rabbit femoral artery thrombosis model (gardell et al, circulation 84:244, 1991). cbt was determined by severing the apex of the nail cuticl ... | 1995 | 7545321 |
| thrombolytic agents in development. | the quest continues for thrombolytic agents with a higher thrombolytic potency, specific thrombolytic activity and/or a better fibrin selectivity. several lines of research towards improvement of thrombolytic agents are being explored, including the construction of mutants and variants of plasminogen activators (pas), chimaeric pas, conjugates of pas with monoclonal antibodies, and pas from animal or bacterial origin. some of these new thrombolytic agents have shown promise in animal models of v ... | 1995 | 7588087 |
| limited fibrin specificity of tissue-type plasminogen activator and its potential link to bleeding. | plasminogen activators initiate the fibrinolytic process by converting plasminogen to plasmin. though plasminogen activators are effective in the treatment of thrombotic disorders, bleeding complications are associated with their use. the development of plasminogen activators with greater fibrin specificity was expected to reduce the incidence of bleeding complications; however, this has not occurred. in our rabbit model (a) bleeding from standardized ear incisions induced by tissue-type plasmin ... | 1995 | 8770837 |
| structural features mediating fibrin selectivity of vampire bat plasminogen activators. | the distinguishing characteristic of vampire bat (desmodus rotundus) salivary plasminogen activators (dspas) is their strict requirement for fibrin as a cofactor. dspas consist of structural modules known from urokinase (u-pa) and tissue-type plasminogen activator (t-pa) such as finger (f), epidermal growth factor (e), kringle (k), and protease (p), combining to four genetically and biochemically distinct isoenzymes, exhibiting the formulas fekp (dspa alpha 1 and alpha 2) and ekp and kp (dspa be ... | 1995 | 7592732 |
| production of vampire bat plasminogen activator dspa alpha 1 in cho and insect cells. | salivary plasminogen activator from the vampire bat desmodus rotundus (dspa alpha 1) is a promising new thrombolytic agent. continuous growth of a stably transfected, methotrexate amplified, dhfr- cho cell line yields up to 60 mg l-1 of dspa alpha 1. utilizing an engineered baculovirus 10 mg l-1 were produced in batches of sf9 insect cells. recombinant dspa alpha 1 is purified from both sources using a one-step purification protocol. although differences in glycosylation were detected, enzymatic ... | 1995 | 7766013 |
| purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (desmodus rotundus). | from the saliva of the vampire bat desmodus rotundus, we isolated an unknown anticoagulant protein which we have named draculin. its molecular mass as determined by non-reduced sds-page is about 83 kda. the reduced polypeptide shows a slower migration. hplc in a molecular sieve matrix yields a single, symmetrical peak corresponding to 88.5 kda. isoelectric focusing shows an acidic protein with pi = 4.1-4.2. aminoacid analysis is compatible with a single chain polypeptide of about 80 kda. cyanoge ... | 1995 | 7740503 |
| o-linked l-fucose is present in desmodus rotundus salivary plasminogen activator. | dspaalpha1 (desmodus rotundus salivary plasminogen activator), a plasminogen activator from the saliva of the vampire bat desmodus rotundus, is an effective thrombolytic agent. an unusual type of posttranslational modification, in which l-fucose is o-glycosidically linked to threonine 61 in the epidermal growth factor domain was found for natural dspaalpha1 and its recombinant form isolated from chinese hamster ovary cells. in the present study a combination of carbohydrate and amino acid compos ... | 1996 | 8631761 |
| genetic characterization of rabies field isolates from venezuela. | twenty samples from cases of rabies in humans and domestic animals diagnosed in venezuela between 1990 and 1994 and one sample from a vampire bat collected in 1976 were characterized by reactivity to monoclonal antibodies against the viral nucleoprotein and by patterns of nucleotide substitution in the nucleoprotein gene. three antigenic variants were found: 1, 3, and 5. antigenic variant 1 included all samples from dogs and humans infected by contact with rabid dogs. unique substitutions permit ... | 1996 | 8735118 |
| the antigen-specific cell-mediated immune response in mice is suppressed by infection with pathogenic lyssaviruses. | responsiveness of t cells (rtc) was studied in balb/c mice intramuscularly infected with various lyssaviruses. after infection by this peripheral route, two types of viruses could be classified according to their effects: 1) pathogenic viruses, including fixed rabies pasteur virus (serogenotype 1) and wild viruses belonging to serogenotype 1 (from a rabid fox in france and from a cow infected by a vampire bat in brazil) or to serogenotype 5 (european bat lyssavirus 1); and 2) non-pathogenic viru ... | 1996 | 8880998 |