Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| mathematical modeling of dengue epidemic: control methods and vaccination strategies. | dengue is, in terms of death and economic cost, one of the most important infectious diseases in the world. so, its mathematical modeling can be a valuable tool to help us to understand the dynamics of the disease and to infer about its spreading by the proposition of control methods. in this paper, control strategies, which aim to eliminate the aedes aegypti mosquito, as well as proposals for the vaccination campaign are evaluated. in our mathematical model, the mechanical control is accomplish ... | 2019 | 30740641 |
| small-molecule agonists of ae. aegypti neuropeptide y receptor block mosquito biting. | female aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. we investigated a role for neuropeptide y (npy)-related signaling in long-term behavioral suppression and discovered that drugs targeting human npy receptors modulate mosquito host-seeking. in a screen of all 49 predicted ae. aegypti peptide receptors, we identified npy-like receptor 7 (npylr7) as the ... | 2019 | 30735632 |
| the perfect appetizer: a pharmacological strategy for a non-biting mosquito. | new possibilities for vector-borne disease control are revealed by duvall et al. (2019), who link host-seeking behavioral modulation in aedes aegypti to neuropeptide y (npy)-like receptor 7. small-molecule screening yields agonist compounds able to activate npylr7 and suppress attraction to hosts. | 2019 | 30735629 |
| loop-mediated isothermal amplification (lamp) for the identification of invasive aedes mosquito species. | invasive aedes mosquito species (diptera: culicidae) are of public health concern in europe because they are either recognized or potential vectors of pathogens. loop-mediated isothermal amplification (lamp) is a rapid and simple method for amplifying dna with high specificity and efficiency, with the technique having potential for application in the field, including in high-throughput format. specific lamp assays based on rdna internal transcribed spacers 1 or 2 sequences, considering intraspec ... | 2019 | 30734975 |
| vertical transmission of zika virus in culex quinquefasciatus say and aedes aegypti (l.) mosquitoes. | several mosquito species have been described as vectors for the zika virus (zikv), such as those in the aedes, anopheles, mansonia and culex genera. our previous survey studies were found the zikv rna positive in both male, female and larvae of culex quinquefasciatus say and aedes aegypti (l.) mosquitoes collected from active zikv infected patients' homes in thailand. therefore, the aims of this study were to investigate whether zikv could be vertically transmitted in cx. quinquefasciatus, ae. a ... | 2019 | 30918310 |
| evaluation of insecticide resistance in aedes aegypti populations connected by roads and rivers: the case of tocantins state in brazil. | the longstanding application of insecticides for vector control without periodic monitoring of the population response to these chemicals can directly drive the selection of resistant populations of vector mosquitoes. tocantins is the newest state of the brazilian federation. despite a historically high number of dengue cases, studies and monitoring data concerning insecticide resistance in the state are lacking. | 2019 | 30916115 |
| understanding the mechanism of chikungunya virus vector competence in three species of mosquitoes. | chikungunya virus (chikv) is primarily transmitted by aedes spp. mosquitoes. the present study investigated vector competence for chikv in aedes aegypti and aedes albopictus mosquitoes found in madurai, south india. the role of receptor proteins on midguts contributing to permissiveness of chikv to aedes spp. mosquitoes was also undertaken. mosquitoes were orally infected with chikv drde-06. infection of midguts and dissemination to heads was confirmed by immunofluorescence assay at different ti ... | 2019 | 30913314 |
| mosquitoes on a diet reduce those pesky bites. | targeting the internal regulation of mosquito's human-seeking capacity provides a novel means for vector control. mosquitoes bite us to obtain blood in order to develop their eggs. professor vosshall and colleagues (cell 2019;176:687-701) have exploited the modulatory pathway to control this hunger for blood by designing drugs based on human diet-suppression pharmaceuticals. | 2019 | 30910491 |
| high-throughput screening method for evaluating spatial repellency and vapour toxicity to mosquitoes. | spatial repellents are an essential tool for personal protection against mosquitoes that bite and transmit disease pathogens to humans. current repellent screening methods, such as olfactometers and alternative choice tests, are complex systems that require a relatively large quantity of compound (mg). the present study validates a high-throughput spatial repellent screening method using a glass tube that has the ends covered with netting, in addition to treated filters and plastic end caps. the ... | 2019 | 30907445 |
| mitochondrial affectation, dna damage and ache inhibition induced by salvia officinalis essential oil on aedes aegypti larvae. | the aim of this research study was to understand the mechanism of action of salvia officinalis (lamiaceae) essential oil (eo) on aedes aegypti larvae. we evaluated the effect on dna damage, acetylcholinesterase (ache) inhibition and mitochondrial enzymatic alterations. the major components were analyzed in silico using osiris and molispiration free software. aedes aegypti dna was extracted from mosquito larvae between third (l3) and fourth (l4) instars to determine the dna fragmentation or degra ... | 2019 | 30905844 |
| phytochemical composition and larvicidal activity of essential oils from herbal plants. | the essential oils (eos) of plectranthus amboinicus showed the highest larvicidal activity among four herbal plants studied and β-caryophyllene might be the major component responsible for its differential toxicity to the larvae of culex quinquefasciatus and aedes aegypti. mosquitoes act as vectors for many life-threatening diseases, including malaria, dengue fever, and zika virus infection. management of mosquitoes mainly relies on synthetic insecticides, which usually result in the rapid devel ... | 2019 | 30904944 |
| publisher correction: past and future spread of the arbovirus vectors aedes aegypti and aedes albopictus. | in the version of this article originally published, the affiliation for author catherine linard was incorrectly stated as '6department of infectious disease epidemiology, london school of hygiene and tropical medicine, london, uk'. the correct affiliation is '9spatial epidemiology lab (spell), universite libre de bruxelles, brussels, belgium'. the affiliation for author hongjie yu was also incorrectly stated as '11department of statistics, harvard university, cambridge, ma, usa'. the correct af ... | 2019 | 30903094 |
| aedes mosquitoes acquire and transmit zika virus by breeding in contaminated aquatic environments. | zika virus (zikv) is a mosquito-borne flavivirus that predominantly circulates between humans and aedes mosquitoes. clinical studies have shown that zika viruria in patients persists for an extended period, and results in infectious virions being excreted. here, we demonstrate that aedes mosquitoes are permissive to zikv infection when breeding in urine or sewage containing low concentrations of zikv. mosquito larvae and pupae, including from field aedes aegypti can acquire zikv from contaminate ... | 2019 | 30902991 |
| self-assembly of chlorin-e6 on γ-fe2o3 nanoparticles: application for larvicidal activity against aedes aegypti. | aedes aegypti mosquitos are widespread vectors of several diseases and their control is of primary importance for biological and environmental reasons, and novel safe insecticides are highly desirable. an eco-friendly photosensitizing magnetic nanocarrier with larvicidal effects on aedes aegypti was proposed. the innovative core-shell hybrid nanomaterial was synthesized by combining peculiar magnetic nanoparticles (called surface active maghemite nanoparticles - samns, the core) and chlorin-e6 a ... | 2019 | 30897400 |
| male accessory gland molecules inhibit harmonic convergence in the mosquito aedes aegypti. | aedes aegypti mosquitoes transmit pathogens such as yellow fever, dengue, zika, and chikungunya viruses to millions of human hosts annually [1]. as such, understanding ae. aegypti courtship and mating biology could prove crucial to the success of disease control efforts that target reproduction. potentially to communicate reproductive fitness [2,3], mosquito males and females harmonize their flight tones prior to mating in a behavior known as harmonic convergence (hc) [4]. furthermore, after mat ... | 2019 | 30889386 |
| environmental concentrations of antibiotics may diminish wolbachia infections in aedes aegypti (diptera: culicidae). | wolbachia-infected aedes aegypti (l.) mosquitoes for control of dengue transmission are being released experimentally in tropical regions of australia, south-east asia, and south america. to become established, the wolbachia hertig (rickettsiales: rickettsiaceae) strains used must induce expression of cytoplasmic incompatibility (ci) in matings between infected males and uninfected females so that infected females have a reproductive advantage, which will drive the infection through field popula ... | 2019 | 30889242 |
| climate change may enable aedes aegypti infestation in major european cities by 2100. | climate change allows aedes aegypti to infest new areas. consequently, it enables the arboviruses the mosquito transmits -- e.g., dengue, chikungunya, zika and yellow fever - to emerge in previously uninfected areas. an example is the portuguese island of madeira during 2012-13. | 2019 | 30884421 |
| update on the geographical distribution and prevalence of aedes aegypti and aedes albopictus (diptera: culicidae), two major arbovirus vectors in cameroon. | arboviral diseases including dengue are increasingly spreading in the tropical/subtropical world including africa. updated knowledge on the distribution and abundance of the major vectors aedes aegypti and aedes albopictus constitutes crucial surveillance action to prepare african countries such as cameroon for potential arbovirus outbreaks. here, we present a nationwide survey in cameroon to assess the current geographical distribution and prevalence of both vectors including a genetic diversit ... | 2019 | 30883552 |
| effects of prenatal exposure to temephos on behavior and social interaction. | the neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (op). the op is neurotoxic and has been associated with neurological diseases pathophysiology. the op temephos is widely used against aedes aegypti in brazil's public health programs. | 2019 | 30880993 |
| heterologous expression of aedes aegypti cation chloride cotransporter 2 (aeccc2) in xenopus laevis oocytes induces an enigmatic na⁺/li⁺ conductance. | the yellow fever mosquito aedes aegypti possesses three genes encoding putative na⁺-coupled cation chloride cotransporters (cccs): aenkcc1, aeccc2, and aeccc3. to date, none of the aecccs have been functionally characterized. here we expressed aeccc2 heterologously in xenopus oocytes and measured the uptake of li⁺ (a tracer for na⁺) and rb⁺ (a tracer for k⁺). compared to control (h₂o-injected) oocytes, the aeccc2-expressing oocytes exhibited significantly greater uptake of li⁺, but not rb⁺. howe ... | 2019 | 30875796 |
| biochemical and functional characterization of glycoside hydrolase family 16 genes in aedes aegypti larvae: identification of the major digestive β-1,3-glucanase. | insect β-1,3-glucanases belong to glycoside hydrolase family 16 (ghf16) and are involved in digestion of detritus and plant hemicellulose. in this work, we investigated the role of ghf16 genes in aedes aegypti larvae, due to their detritivore diet. aedes aegypti genome has six genes belonging to ghf16 (aae gh16.1 - aae gh16.6), containing two to six exons. sequence analysis suggests that five of these ghf16 sequences (aae gh16.1, 2, 3, 5, and 6) contain the conserved catalytic residues of this f ... | 2019 | 30873040 |
| development and validation of reverse transcription loop-mediated isothermal amplification (rt-lamp) for rapid detection of zikv in mosquito samples from brazil. | the rapid spread of zika virus (zikv) represents a global public health problem, especially in areas that harbor several mosquito species responsible for virus transmission, such as brazil. in these areas, improvement in mosquito control needs to be a top priority, but mosquito viral surveillance occurs inefficiently in zikv-endemic countries. quantitative reverse transcription pcr (qrt-pcr) is the gold standard for molecular diagnostic of zikv in both human and mosquito samples. however, the te ... | 2019 | 30872672 |
| the pharmacological and functional characterization of the serotonergic system in anopheles gambiae and aedes aegypti: influences on flight and blood-feeding behavior. | aedes aegypti and anopheles gambiae harbor the causative agents of diseases such as dengue fever and malaria, afflicting human morbidity and mortality worldwide. given the worldwide emergence of resistance to insecticides, the current mainstay for vector control, identification of alternative modes of action for future insecticides is paramount. the serotonergic (5-ht) system has been documented to impact physiological mechanisms involved in disease transmission, suggesting its potential as a ne ... | 2019 | 30872615 |
| protein expression in female salivary glands of pyrethroid-susceptible and resistant strains of aedes aegypti mosquitoes. | a group of insecticides called pyrethroids has been used extensively worldwide and development of pyrethroid resistance within mosquito populations, especially in aedes aegypti, has rapidly spread through populations. in this study, sds-page, 2-de coupled with nanolc-ms, and bioinformatics were used to analyze the female salivary gland proteins of pyrethroid-susceptible (pmd) and pyrethroid-resistant (pmd-r and upk-r) strains of ae. aegypti mosquitoes for the first time. | 2019 | 30871604 |
| evidence for the natural occurrence of wolbachia in aedes aegypti mosquitoes. | wolbachia, a gram-negative bacterium, is widely known to be present in arthropods and nematodes. of late, great impetus is given to employ this intracellular bacterium, as an alternative to conventional biocontrol agents for the control of mosquitoes because of its inherent ability to induce sperm-egg incompatibility, feminisation etc. by employing molecular tools, we have shown the presence of wolbachia from aedes aegypti mosquito population collected from coimbatore, india by pcr amplifying th ... | 2019 | 30869785 |
| corrigendum to "larvicidal potential of five selected dragonfly nymphs in sri lanka over aedes aegypti (linnaeus) larvae under laboratory settings". | [this corrects the article doi: 10.1155/2018/8759459.]. | 2019 | 30868069 |
| first dengue virus seroprevalence study on madeira island after the 2012 outbreak indicates unreported dengue circulation. | in 2012, the first dengue virus outbreak was reported on the portuguese island of madeira with 1080 confirmed cases. dengue virus of serotype 1 (denv-1), probably imported from venezuela, caused this outbreak with autochthonous transmission by invasive aedes aegypti mosquitoes. | 2019 | 30867031 |
| genome-wide divergence among invasive populations of aedes aegypti in california. | in the summer of 2013, aedes aegypti linnaeus was first detected in three cities in central california (clovis, madera and menlo park). it has now been detected in multiple locations in central and southern ca as far south as san diego and imperial counties. a number of published reports suggest that ca populations have been established from multiple independent introductions. | 2019 | 30866822 |
| naturally infected aedes aegypti collected during a zika virus outbreak have viral titres consistent with transmission. | 2019 | 30866777 | |
| costs of an aedes aegypti vector control program. | 2019 | 30864616 | |
| larvicidal activity of selected essential oil in synergized combinations against aedes aegypti. | this study was conducted to attain an alternate plant essential oil (eo) based mosquito larvicide against the dengue vector aedes aegypti. here three plants were selected based on their local availability, safety and insecticidal properties. eos were extracted from syzygium aromaticum (myrtaceae) flower buds, fruits of illicium verum (schisandraceae) and trachyspermum ammi (apiaceae) by hydro-distillation and tested against ae. aegypti larvae individually and in combinations to find synergistic ... | 2019 | 30861442 |
| global outbreaks and origins of a chikungunya virus variant carrying mutations which may increase fitness for aedes aegypti: revelations from the 2016 mandera, kenya outbreak. | in 2016, a chikungunya virus (chikv) outbreak was reported in mandera, kenya. this was the first major chikv outbreak in the country since the global reemergence of this virus in kenya in 2004. we collected samples and sequenced viral genomes from this outbreak. all kenyan genomes contained two mutations, e1:k211e and e2:v264a, recently reported to have an association with increased infectivity, dissemination, and transmission in the aedes aegypti vector. phylogeographic inference of temporal an ... | 2019 | 30860010 |
| aedes aegypti agbr1 antibodies modulate early zika virus infection of mice. | a recent epidemic of zika virus in the americas, affecting well over a million people, caused substantial mortality and morbidity, including guillain-barre syndrome, microcephaly and other fetal developmental defects1,2. preventive and therapeutic measures that specifically target the virus are not readily available. the transmission of zika virus is predominantly mosquito-borne, and aedes aegypti mosquitoes serve as a key vector for zika virus3. here, to identify salivary factors that modulate ... | 2019 | 30858571 |
| modeling the impact of sterile males on an aedes aegypti population with optimal control. | we use partial differential equations to describe the dynamics of an aedes aegypti mosquito population on an island, and the effects of a sterile male release. the model includes mosquito movement and an allee effect to capture extinction events. we apply optimal control theory to identify the release strategy that eliminates the mosquitoes most rapidly, conditional on a limited availability of sterile males. the optimal solution for a single location is to initially release a substantial number ... | 2019 | 30857942 |
| laboratory evaluation of larvicidal and oviposition deterrent properties of edible plant oils for potential management of aedes aegypti (diptera: culicidae) in drinking water containers. | the yellow fever mosquito, aedes aegypti (diptera: culicidae) transmits several devastating arboviruses, including dengue, chikungunya, and zika virus, making development of inexpensive and eco-friendly strategies for its control an urgent priority. we evaluated the lethality of 13 commonly used plant-derived edible oils against late-third instar ae. aegypti and then tested the three most lethal oils for stage-specific differences in lethality. we also examined the effects of the most lethal (he ... | 2019 | 30855084 |
| udp-glycosyltransferase genes and their association and mutations associated with pyrethroid resistance in anopheles sinensis (diptera: culicidae). | udp-glycosyltransferase (ugt) is an important biotransformation superfamily of enzymes. they catalyze the transfer of glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules, and function in several physiological processes, including detoxification, olfaction, cuticle formation, pigmentation. the diversity, classification, scaffold location, characteristics, phylogenetics, and evolution of the superfamily of genes at whole genome level, and their association and muta ... | 2019 | 30845961 |
| molecular epidemiology and genetic diversity of zika virus from field-caught mosquitoes in various regions of thailand. | zika virus (zikv) infection is an emerging and re-emerging arbovirus disease that is transmitted to humans through the bite of infected mosquitoes. zikv infections were first described in thailand in 1954 from the sera of indigenous residents and several travelers returning from thailand in 2014. however, reported cases in thailand have been increasing since 2015 and 2016, and epidemiological information about the vectors of zikv is unclear. we investigated the molecular epidemiology and genetic ... | 2019 | 30845707 |
| updated methods for the production of toxorhynchites rutilus septentrionalis (diptera, culicidae) for use as biocontrol agent against container breeding pest mosquitoes in harris county, texas. | the complex biologies of pestiferous mosquito species complicate the development of a single, across the board effective control measure. the use of traditional biological control through predators, parasitoids, and microbes, though part of a multimodal, integrated pest management approach, is scant in current standard mosquito control operations. at this time, traditional, whole organism mosquito biocontrol agents are not commercially available, and if their integration into a release program i ... | 2019 | 30843583 |
| urban and semi-urban mosquitoes of mexico city: a risk for endemic mosquito-borne disease transmission. | since past century, vector-borne diseases have been a major public health concern in several states of mexico. however, mexico city continues to be free of endemic mosquito-borne viral diseases. the city is the most important politic and economic state of mexico and one of the most important city of latin america. its subtropical highland climate and high elevation (2240 masl) had historically made the occurrence of aedes species unlikely. however, the presence of other potential disease vectors ... | 2019 | 30840661 |
| impacts of hurricanes irma and maria on aedes aegypti populations, aquatic habitats, and mosquito infections with dengue, chikungunya, and zika viruses in puerto rico. | puerto rico was severely impacted by hurricanes irma and maria in september 2017. the island has been endemic for dengue viruses (denv) and recently suffered epidemics of chikungunya (chikv 2014) and zika (zikv 2016) viruses. although severe storms tend to increase the number of vector and nuisance mosquitoes, we do not know how they influence aedes aegypti populations and arboviral transmission. we compared the abundance of female ae. aegypti in autocidal gravid ovitraps (ago traps), container ... | 2019 | 30963992 |
| publisher correction: past and future spread of the arbovirus vectors aedes aegypti and aedes albopictus. | this article was mistakenly not made open access when originally published; this has now been amended, and information about the creative commons attribution 4.0 international license has been added into the 'additional information' section. | 2019 | 30962571 |
| differences in mosquito communities in six cities in oklahoma. | vector-borne diseases in the united states have recently increased as a result of the changing nature of vectors, hosts, reservoirs, pathogens, and the ecological and environmental conditions. current information on vector habitats and how mosquito community composition varies across space and time is vital to successful vector-borne disease management. this study characterizes mosquito communities in urban areas of oklahoma, united states, an ecologically diverse region in the southern great pl ... | 2019 | 30950499 |
| vector competence of australian aedes aegypti and aedes albopictus for an epidemic strain of zika virus. | recent epidemics of zika virus (zikv) in the pacific and the americas have highlighted its potential as an emerging pathogen of global importance. both aedes (ae.) aegypti and ae. albopictus are known to transmit zikv but variable vector competence has been observed between mosquito populations from different geographical regions and different virus strains. since australia remains at risk of zikv introduction, we evaluated the vector competence of local ae. aegypti and ae. albopictus for a braz ... | 2019 | 30946747 |
| linking water quality to aedes aegypti and zika in flood-prone neighborhoods. | the ability of ecosystems to regulate water quality and flood events has been linked to health outcomes, including mosquito-borne illnesses. in the san juan bay estuary watershed of puerto rico, habitat alterations and land-use development have disrupted watershed hydrology, exacerbating wastewater discharges and subjecting some neighborhoods to frequent flooding events. in 2016, the mosquito-borne illness zika became a new cause for concern. we hypothesized that nutrient-enriched flood water co ... | 2019 | 30945160 |
| interpreting mosquito feeding patterns in australia through an ecological lens: an analysis of blood meal studies. | mosquito-borne pathogens contribute significantly to the global burden of disease, infecting millions of people each year. mosquito feeding is critical to the transmission dynamics of pathogens, and thus it is important to understanding and interpreting mosquito feeding patterns. in this paper we explore mosquito feeding patterns and their implications for disease ecology through a meta-analysis of published blood meal results collected across australia from more than 12,000 blood meals from 22 ... | 2019 | 30944025 |
| v1016g point mutation: the key mutation in the voltage-gated sodium channel (vgsc) gene of pyrethroid-resistant aedes aegypti (diptera: culicidae) in indonesia. | resistance to pyrethroid insecticides is widespread in indonesian aedes aegypti (linnaeus), the primary vector of dengue viruses. this study aims to investigate the mutations in the voltage-gated sodium channel (vgsc) conferring pyrethroid resistance against ae. aegypti populations from indonesia. molecular genotyping of mutations using polymerase chain reaction assay and direct dna sequencing were performed at positions 989 and 1,016 in iis6 region, and 1,534 in iiis6 region of the voltage-gate ... | 2019 | 30942885 |
| influence of strategic points in the dispersion of aedes aegypti in infested areas. | to evaluate whether sites with large amount of potential breeding sites for immature forms of aedes aegypti, called strategic points, influence in the active vector's dispersion into properties in their surroundings. | 2019 | 30942271 |
| detrimental effects of induced antibodies on aedes aegypti reproduction. | aedes aegypti (linnaeus) (diptera: culicidae) is the main vector of viruses causing dengue, chikungunya, zika, and yellow fever, worldwide. this report focuses on immuno-blocking four critical proteins in the female mosquito when fed on blood containing antibodies against ferritin, transferrin, one amino acid transporter (naat1), and acetylcholinesterase (ache). peptides from these proteins were selected, synthetized, conjugated to carrier proteins, and used as antigens to immunize new zealand r ... | 2019 | 30941675 |
| correction to: complete nmr chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, aedes aegypti, bound to arachidonic acid. | the article listed above was initially published with incorrect copyright information. upon publication of this correction, the copyright of the article is changed to "the author(s)". the original article has been corrected. | 2019 | 30941584 |
| glycoprotein hormone receptor knockdown leads to reduced reproductive success in male aedes aegypti. | glycoprotein hormone receptors mediate a diverse range of physiological functions in vertebrate and invertebrate organisms. the heterodimeric glycoprotein hormone gpa2/gpb5 and its receptor lgr1, constitute a recently discovered invertebrate neuroendocrine signaling system that remains to be functionally characterized. we previously reported that lgr1 is expressed in the testes of adult aedes aegypti mosquitoes, where its immunoreactivity is particularly regionalized. here, we show that lgr1 imm ... | 2019 | 30941056 |
| enhanced mosquitocidal efficacy of colloidal dispersion of pyrethroid nanometric emulsion with benignity towards non-target species. | the rising threat of vector-borne diseases and environmental pollution has instigated the investigation of nanotechnology-based applications. the current study deals with a nanotechnological application involving the usage of nanometric pesticides such as permethrin nanoemulsion. the mean droplet diameter and zeta potential of the prepared permethrin nanoemulsion were found to be 12.4 ± 1.13 nm and -20.4 ± 0.56 mv, respectively. the temporal stability of permethrin nanoemulsion was found to be 4 ... | 2019 | 30939406 |
| endogenous non-retroviral elements in genomes of aedes mosquitoes and vector competence. | recent extensive (re)emergences of arthropod-borne viruses (arboviruses) such as chikungunya (chikv), zika (zikv) and dengue (denv) viruses highlight the role of the epidemic vectors, aedes aegypti and aedes albopictus, in their spreading. differences of vector competence to arboviruses highlight different virus/vector interactions. while both are highly competent to transmit chikv (alphavirus,togaviridae), only ae. albopictus is considered as a secondary vector for denv (flavivirus, flavivirida ... | 2019 | 30938223 |
| larvicidal, histopathological, antibacterial activity of indigenous fungus penicillium sp. against aedes aegypti l and culex quinquefasciatus (say) (diptera: culicidae) and its acetylcholinesterase inhibition and toxicity assessment of zebrafish (danio rerio). | fungal metabolites are considered to be most efficient tools to overcome the issues related to insecticide resistance and environmental pollution. the present study focus on the evaluation of the mosquito larvicidal efficacy of metabolites of seven indigenous fungal isolates (penicillium sp. aspergillus niger, a. flavus, a. parasiticus, rhizopus sp. mucor sp. and aspergillus sp.) on the larvae of aedes aegypti and culex quinquefasciatus under the laboratory condition. the preliminary screening o ... | 2019 | 30936853 |
| local transmission of zika virus in miami-dade county: the florida department of health rises to the challenge. | as early as 2015, florida and centers for disease control and prevention (cdc) public health officials recognized the potential danger of zika for us residents and visitors. the zika virus, a mosquito-borne flavivirus, is transmitted through the bite of the aedes aegypti mosquito. a physician in miami-dade notified the florida department of health (doh) of the first non-travel-related zika case in the united states. a 23-year old pregnant woman had presented on july 7, 2016, at 23 weeks of gesta ... | 2019 | 30933006 |
| aedes aegypti mosquitoes detect acidic volatiles found in human odor using the ir8a pathway. | mosquitoes use olfaction as a primary means of detecting their hosts. previously, the functional ablation of a family of aedes aegypti olfactory receptors, the odorant receptors (ors), was not sufficient to reduce host seeking in the presence of carbon dioxide (co2). this suggests the olfactory receptors that remain, such as the ionotropic receptors (irs), could play a significant role in host detection. to test this, we disrupted the ir8a co-receptor in ae. aegypti using crispr/cas9. we found t ... | 2019 | 30930038 |
| evaluation of toxicity and environmental safety in use of spinosad to rationalize control strategies against aedes aegypti. | spinosad is a naturally-occurring insecticide used for the management of ae. aegypti larvae. the assessment of ecotoxicological parameters of spinosad is required for verifying the environmentally-friendly behavior of the compound and for evaluating toxicity values on non-target species. thus, the aim of the study was to conduct toxicity tests using daphnia magna as model organism after exposure to different concentrations of spinosad. immobility effects were observed in both acute and chronic t ... | 2019 | 30927668 |
| preliminary screening of mosquito spatial distribution in togo: with special focus on the aedes (diptera: culicidae) species. | the togolese republic has a tropical and humid climate which constitutes an ideal environment for mosquitoes to breed and transmit diseases. the aedes mosquito is known to transmit yellow fever (yf), dengue, chikungunya, and zika viruses in west africa. togo has been suffering from yf virus transmission, despite vaccination efforts. unfortunately, there is scarcity in the data that reflect mosquito spatial distribution in togo, specifically possible yf vectors. in the current study, mosquito sur ... | 2019 | 30927005 |
| voltage-gated sodium channel intron polymorphism and four mutations comprise six haplotypes in an aedes aegypti population in taiwan. | knockdown resistance (kdr) to dichlorodiphenyltrichloroethane (ddt) and pyrethroids is known to link amino acid substitutions in the voltage-gated sodium channel (vgsc) in aedes aegypti. dengue fever primarily transmitted by ae. aegypti is an annual public health issue in taiwan. accordingly, pyrethroid insecticides have been heavily used for decades to control mosquito populations in the summer and autumn. in taiwan, an ae. aegypti population with two vgsc mutations, v1016g and d1763y, was desc ... | 2019 | 30925149 |
| the electronic song "scary monsters and nice sprites" reduces host attack and mating success in the dengue vector aedes aegypti. | sound and its reception are crucial for reproduction, survival, and population maintenance of many animals. in insects, low-frequency vibrations facilitate sexual interactions, whereas noise disrupts the perception of signals from conspecifics and hosts. despite evidence that mosquitoes respond to sound frequencies beyond fundamental ranges, including songs, and that males and females need to struggle to harmonize their flight tones, the behavioral impacts of music as control targets remain unex ... | 2019 | 30922800 |
| use of mechanical and behavioural methods to eliminate female aedes aegypti and aedes albopictus for sterile insect technique and incompatible insect technique applications. | sex separation of mosquitoes at different stages is currently being attempted to ensure the successful release of male mosquitoes in novel vector control approaches. mechanical and behavioral techniques have been tried most frequently. | 2019 | 30922368 |
| investigating the probability of establishment of zika virus and detection through mosquito surveillance under different temperature conditions. | because of the increasing threat that zika virus (zikv) poses to more sub-tropical area due to increased global travel, there is a need for better understanding of the effect(s) of temperature on the establishment potential of zikv within these subtropical, temperate, and/or seasonal ae. aegypti populations. the first step to determining risk establishment of zikv in these regions is to assess zikv's ability to infect mosquitoes at less tropical temperatures, and thus be detected through common ... | 2019 | 30921386 |
| global expansion and redistribution of aedes-borne virus transmission risk with climate change. | forecasting the impacts of climate change on aedes-borne viruses-especially dengue, chikungunya, and zika-is a key component of public health preparedness. we apply an empirically parameterized model of viral transmission by the vectors aedes aegypti and ae. albopictus, as a function of temperature, to predict cumulative monthly global transmission risk in current climates, and compare them with projected risk in 2050 and 2080 based on general circulation models (gcms). our results show that if ... | 2019 | 30921321 |
| modelling the potential distribution of arbovirus vector aedes aegypti under current and future climate scenarios in taiwan, china. | aedes aegypti is one of the most important mosquito species and is a common disease-transmitting pest in tropical areas. various infectious arbovirus diseases can be transmitted by ae. aegypti. with ongoing global climate change, we are facing an increasing public health threat from the rapid spread of disease vectors into wider geographical areas. to better understand the current ecological niche range and possible future expansion of ae. aegypti, an ecological niche modelling approach was adop ... | 2019 | 30919547 |
| geometric morphometric analysis of the effect of temperature on wing size and shape in aedes albopictus. | wing geometry helps to identify mosquito species, even cryptic ones. on the other hand, temperature has a well-known effect on insect metric properties. can such effects blur the taxonomic signal embedded in the wing? two strains of aedes albopictus (laboratory and field strain) were examined under three different rearing temperatures (26, 30 and 33 °c) using landmark- and outline-based morphometric approaches. the wings of each experimental line were compared with aedes aegypti. both approaches ... | 2019 | 31125148 |
| new records of aedes aegypti and aedes albopictus in eight texas counties, u.s.a. | 2019 | 31124239 | |
| spatial repellency and other effects of transfluthrin and linalool on aedes aegypti and aedes albopictus. | in the present study, the effects of two spatial repellents (sr) were determined for aedes aegypti and ae albopictus, the main vectors of dengue, chikungunya, and zika fever. the modular high-throughput screening system (hitss) was used to evaluate the response of both species to transfluthrin and linalool sr at different concentrations. the highest spatial repellency results for ae. aegypti were obtained by transfluthrin to 0.001% with 37.50 ± 4.33%, and for linalool to 10% with 77.50 ± 3.90%. ... | 2019 | 31124222 |
| diet drugs trick mosquitoes into feeling full. | after a bloodmeal, aedesaegypti mosquitoes lose interest in bloodfeeding. duvall et al. (cell 2019;176:687-701) determined that the neuropeptide y (npy)-like receptor 7 (npylr7) controls mosquito satiety and also identified six npylr7 drug targets that suppress biting. this work highlights an innovative approach in vector control linking insect behavior to drug discovery. | 2019 | 31122765 |
| excito-repellent activity of β-caryophyllene oxide against aedes aegypti and anopheles minimus. | contact irritant and non-contact repellent activities of β-caryophyllene oxide were evaluated against laboratory strains of female aedes aegypti (usda strain), a major arbovirus vector and anopheles minimus (ku strain), a major malaria parasite vector, compared with the synthetic repellent deet, using an excito-repellency test system. β-caryophyllene oxide and deet were tested at concentrations of 0.1, 0.25, 0.5 and 1.0% (v/v). anopheles minimus was found to be more sensitive to β-caryophyllene ... | 2019 | 31121148 |
| identification of molecular determinants of resistance to pyrethroid insecticides in aedes aegypti (diptera: culicidae) populations in california, usa. | the first breeding populations of aedes aegypti (linnaeus) were identified in california in 2013, and have since been detected in 13 counties. recent studies suggest two introductions likely occurred, with genetically distinct populations in the central and southern regions of the state. given the threat of dengue, chikungunya, and zika virus transmission, it is imperative to understand if these populations harbor genes that could confer resistance to pyrethrin-based insecticides, known as pyret ... | 2019 | 31121042 |
| uncertainty analysis of species distribution models. | the maximum entropy model, a commonly used species distribution model (sdm) normally combines observations of the species occurrence with environmental information to predict the geographic distributions of animal or plant species. however, it only produces point estimates for the probability of species existence. to understand the uncertainty of the point estimates, we analytically derived the variance of the outputs of the maximum entropy model from the variance of the input. we applied the an ... | 2019 | 31120909 |
| insecticide resistance levels and mechanisms in aedes aegypti populations in and around ouagadougou, burkina faso. | recent outbreaks of dengue and other aedes aegypti-borne arboviruses highlight the importance of a rapid response for effective vector control. data on insecticide resistance and underlying mechanisms are essential for outbreak preparedness, but are sparse in much of africa. we investigated the levels and heterogeneity of insecticide resistance and mechanisms of ae. aegypti from contrasting settings within and around ouagadougou, burkina faso. | 2019 | 31120874 |
| topological qsar modelling of carboxamides repellent activity to aedes aegypti. | aedes aegypti vector control is of paramount importance owing to the damages induced by the various severe diseases that these insects may transmit, and the increasing risk of important outbreaks of these pathologies. search for new chemicals efficient against aedes aegypti, and devoid of side-effects, which have been associated to the currently most used active substance i. e. n,n-diethyl-m-toluamide (deet), is therefore an important issue. in this context, we developed various quantitative str ... | 2019 | 31120598 |
| entomological efficacy of aerial ultra-low volume insecticide applications against aedes aegypti (diptera: culicidae) in mexico. | a cluster-randomized controlled trial quantified the entomological efficacy of aerial ultra-low volume (aulv) applications of the insecticide chlorpyrifos against aedes aegypti in puerto vallarta, méxico, during november-october 2017. the trial involved 16 large (1 × 1 km) clusters distributed between treatment-control arms. primary endpoint was the abundance of ae. aegypti indoors (total adults, females, and blood-fed females) collected using prokopack aspirators. after four consecutive weekly ... | 2019 | 31120502 |
| wolbachia strain walba blocks zika virus transmission in aedes aegypti. | transinfections of the maternally transmitted endosymbiont wolbachia pipientis can reduce rna virus replication and prevent transmission by aedes aegypti, and also have the capacity to invade wild-type populations, potentially reaching and maintaining high infection frequencies. levels of virus transmission blocking are positively correlated with wolbachia intracellular density. despite reaching high densities in ae. aegypti, transinfections of walba, a strain native to aedes albopictus, showed ... | 2019 | 31120156 |
| larvicidal activity of hypoestes forskaolii (vahl) r. br root extracts against anopheles gambiae giless.s, aedes aegypti l, and culex quinquefasciatussay. | aim: this study aimed to evaluate larvicidal activity of hypoestes forskaolii r. br root extract against 3rd instar anopheles gambiae, aedes aegypti, and culex quinquefasciatus. methods: a protocol developed by the world health organization was adopted, with minor modification using chloroform and methanol extracts with concentrations ranging from 25-750 µg/ml. results: the h. forskaolii chloroform extract exhibited very high larvicidal activity after 72 hours of exposure, with lc50 2.0322, 3.89 ... | 2019 | 31118834 |
| characterization of a broad-based mosquito yeast interfering rna larvicide with a conserved target site in mosquito semaphorin-1a genes. | rna interference (rnai), which has facilitated functional characterization of mosquito neural development genes such as the axon guidance regulator semaphorin-1a (sema1a), could one day be applied as a new means of vector control. saccharomyces cerevisiae (baker's yeast) may represent an effective interfering rna expression system that could be used directly for delivery of rna pesticides to mosquito larvae. here we describe characterization of a yeast larvicide developed through bioengineering ... | 2019 | 31118082 |
| [experiences, barriers and facilitators to the implementation of interventions for controlling aedes aegypti in latin america and the caribbean: a qualitative study]. | this study sought to describe experiences, barriers and facilitators to the implementation of interventions for controlling aedes aegypti in latin america and the caribbean. a qualitative approach with semi-structured in-depth interviews with program implementation experts (19 participants in nine countries) was carried out. we used a software to codify the data and created matrices to compare them. based on our findings, we developed a graphic representation of the theoretical dimensions that e ... | 2019 | 31116251 |
| aedes mosquito infestation in socioeconomically contrasting neighborhoods of panama city. | the global expansion and proliferation of aedes aegypti and aedes albopictus represents a growing public health threat due to their capacity to transmit a variety of arboviruses to humans, including dengue, chikungunya, and zika. particularly important in urban regions, where these species have evolved to breed in man-made containers and feed nearly exclusively on human hosts, the threat of vector-borne disease has risen in recent decades due to the growth of cities, progression of climate chang ... | 2019 | 31114946 |
| estimating absolute indoor density of aedes aegypti using removal sampling. | quantification of adult aedes aegypti abundance indoors has relied on estimates of relative density (e.g. number of adults per unit of sampling or time), most commonly using traps or timed collections using aspirators. the lack of estimates of the sensitivity of collections and lack of a numerical association between relative and the absolute density of adult ae. aegypti represent a significant gap in vector surveillance. here, we describe the use of sequential removal sampling to estimate absol ... | 2019 | 31113454 |
| use of mosquito repellents to protect against zika virus infection among pregnant women in brazil. | to evaluate the use of repellents among pregnant women as a protective measure against infection with the zika virus. | 2019 | 31112836 |
| predicting aquatic development and mortality rates of aedes aegypti. | mosquito-borne pathogens continue to be a significant burden within human populations, with aedes aegypti continuing to spread dengue, chikungunya, and zika virus throughout the world. using data from a previously conducted study, a linear regression model was constructed to predict the aquatic development rates based on the average temperature, temperature fluctuation range, and larval density. additional experiments were conducted with different parameters of average temperature and larval den ... | 2019 | 31112566 |
| the ion channel ppk301 controls freshwater egg-laying in the mosquito aedes aegypti. | female aedes aegypti mosquitoes are deadly vectors of arboviral pathogens and breed in containers of freshwater associated with human habitation. because high salinity is lethal to offspring, correctly evaluating water purity is a crucial parenting decision. we found that the deg/enac channel ppk301 and sensory neurons expressing ppk301 control egg-laying initiation and choice in ae. aegypti. using calcium imaging, we found that ppk301-expressing cells show ppk301-dependent responses to water bu ... | 2019 | 31112133 |
| juvenile hormone signaling in insect oogenesis. | juvenile hormone (jh) plays a crucial role in insect reproduction, but its molecular mode of action only became clear within the last decade. we here review recent findings revealing the intricate crosstalk between jh and ecdysone signaling with nutrient sensing pathways in drosophila melanogaster, aedes aegypti, tribolium castaneum and locusta migratoria. the finding for a critical role of ecdysis triggering hormone (eth) in both molting and ooogenesis now also highlights the importance of an i ... | 2019 | 31109672 |
| transmission potential of african, asian and american zika virus strains by aedes aegypti and culex quinquefasciatus from guadeloupe (french west indies). | zika virus (zikv) is an arbovirus that has dramatically spread in south america and the caribbean regions since 2015. the majority of vector incrimination studies available for zikv showed that aedes aegypti mosquitoes are important vectors for this virus. however, several reports suggest that culex quinquefasciatus mosquitoes may be implicated in zikv transmission in certain urban settings. in the present study, we evaluated the vector competence for zikv of cx. quinquefasciatus and ae. aegypti ... | 2019 | 31109248 |
| pathogen blocking in wolbachia-infected aedes aegypti is not affected by zika and dengue virus co-infection. | wolbachia's ability to restrict arbovirus transmission makes it a promising tool to combat mosquito-transmitted diseases. wolbachia-infected aedes aegypti are currently being released in locations such as brazil, which regularly experience concurrent outbreaks of different arboviruses. a. aegypti can become co-infected with, and transmit multiple arboviruses with one bite, which can complicate patient diagnosis and treatment. | 2019 | 31107912 |
| tire shops in miami-dade county, florida are important producers of vector mosquitoes. | human mobility in urban environments is a central part of urbanization and has determined the layout of how cities are projected, built and renovated. one of the most problematic issues of urbanization is how to properly dispose of used tires, considering the worldwide annual production of approximately 1.4 billion units every year. despite the efforts to properly dispose of used tires, they still represent a major problem for public health, notably serving as potential breeding sites for vector ... | 2019 | 31107881 |
| characterization of a yeast interfering rna larvicide with a target site conserved in the synaptotagmin gene of multiple disease vector mosquitoes. | new mosquito control strategies are vitally needed to address established and emerging arthropod-borne infectious diseases. here we describe the characterization of a yeast interfering rna larvicide that was developed through the genetic engineering of saccharomyces cerevisiae (baker's yeast) to express a short hairpin rna targeting the aedes aegypti synaptotagmin (aae syt) gene. the larvicide effectively silences the aae syt gene, causes defects at the larval neural synapse, and induces high ra ... | 2019 | 31107878 |
| neurological manifestations of pediatric arboviral infections in the americas. | dengue, zika, chikungunya and yellow fever viruses are arboviruses transmitted by the mosquito aedes aegypti. these viruses exhibit marked neurotropism but have rarely been studied. here, we conduct an integrative review of the neurological manifestations caused by these arboviruses in the pediatric population. data on patients under 18 years of age were extracted from literature databases. the most frequently reported neurological manifestations were encephalitis, meningitis, seizures, hypotoni ... | 2019 | 31103802 |
| induction of rna interference to block zika virus replication and transmission in the mosquito aedes aegypti. | the yellow fever mosquito, aedes aegypti, serves as the primary vector for epidemic transmission of yellow fever, dengue, zika (zikv), and chikungunya viruses to humans. control of ae. aegypti is currently limited to insecticide applications and larval habitat management; however, to combat growing challenges with insecticide resistance, novel genetic approaches for vector population reduction or transmission interruption are being aggressively pursued. the objectives of this study were to asses ... | 2019 | 31103782 |
| plant essential oils synergize various pyrethroid insecticides and antagonize malathion in aedes aegypti. | pyrethroid resistance is a significant threat to agricultural, urban and public health pest control activities. because economic incentives for the production of novel active ingredients for the control of public health pests are lacking, this field is particularly affected by the potential failure of pyrethroid-based insecticides brought about by increasing pyrethroid resistance. as a result, innovative approaches are desperately needed to overcome insecticide resistance, particularly in mosqui ... | 2019 | 31102301 |
| prevalence and distribution of dengue virus in aedes aegypti in yogyakarta city before deployment of wolbachia infected aedes aegypti. | indonesia is one of the countries where dengue infection is prevalent. in this study we measure the prevalence and distribution of dengue virus (denv) denv-infected aedes aegypti in yogyakarta city, indonesia, during the wet season when high dengue transmission period occurred, as baseline data before implementation of a wolbachia-infected aedes aegypti trial for dengue control. we applied one-step multiplex real time pcr (rt-pcr) for the type-specific-detection of dengue viruses in field-caught ... | 2019 | 31100967 |
| aedes aegypti saliva impairs m1-associated proinflammatory phenotype without promoting or affecting m2 polarization of murine macrophages. | during the feeding process, the mouthparts of hematophagous mosquitoes break the skin barrier and probe the host tissue to find the blood. the saliva inoculated in this microenvironment modulates host hemostasis, inflammation and adaptive immune responses. however, the mechanisms involved in these biological activities remain poorly understood and few studies explored the potential roles of mosquito saliva on the individual cellular components of the immune system. here, we report the immunomodu ... | 2019 | 31097013 |
| enzymatic and molecular characterization of insecticide resistance mechanisms in field populations of aedes aegypti from selangor, malaysia. | dengue is a serious public health problem worldwide, including in selangor, malaysia. being an important vector of dengue virus, aedes aegypti are subjected to control measures which rely heavily on the usage of insecticides. evidently, insecticide resistance in ae. aegypti, which arise from several different point mutations within the voltage-gated sodium channel genes, has been documented in many countries. thus, this robust study was conducted in all nine districts of selangor to understand t ... | 2019 | 31097010 |
| re-emergence of chikungunya in the republic of the congo in 2019 associated with a possible vector-host switch. | in january 2019, an outbreak of chikungunya virus fever was reported in a rural region near pointe-noire, republic of the congo. molecular and phylogenetic analysis of this new chikv strain demonstrated the presence of the a226v substitution and a surprisingly close relation with aedes aegypti-associated central africa chikungunya strains. these results, combined with the preponderance of aedes albopictus in the outbreak area, suggest a recent vector-host switch facilitated by the emergence and ... | 2019 | 31096054 |
| zika virus detection, isolation and genome sequencing through culicidae sampling during the epidemic in vitória, espírito santo, brazil. | zika virus (zikv) has been isolated from many mosquito species in nature, but it is believed that the main vectors in urban environments are species of the genus aedes. here, we detected and isolated zikv in samples from aedes aegypti, aedes taeniorhynchus and culex quinquefasciatus, collected during the zika epidemic in vitória, southeast brazil. using quantitative real-time polymerase chain reaction, zikv detection was performed in mosquito samples collected from february to april 2016. | 2019 | 31068218 |
| determination of the spatial susceptibility to yellow fever using a multicriteria analysis. | the outbreak of sylvatic yellow fever (syf) in humans during 2016-2017 in brazil is one of the greatest in the history of the disease. the occurrence of the disease in areas with low vaccination coverage favoured the dissemination of the disease; therefore, it is necessary to identify the areas vulnerability to the yf virus (yfv) to assist in the adoption of preventive measures. | 2019 | 31066755 |
| embryonic development and egg viability of wmel-infected aedes aegypti. | aedes aegypti is a major disease vector in urban habitats, involved in the transmission of dengue, chikungunya and zika. despite innumerous attempts to contain disease outbreaks, there are neither efficient vaccines nor definite vector control methods nowadays. in recent years, an innovative strategy to control arboviruses, which exploits the endosymbiotic bacterium wolbachia pipientis, emerged with great expectations. the success of the method depends on many aspects, including wolbachia's cyto ... | 2019 | 31060581 |
| arboviral screening of invasive aedes species in northeastern turkey: west nile virus circulation and detection of insect-only viruses. | the recent reports of aedes aegypti and ae. albopictus populations in turkey, in parallel with the territorial expansion identified in several surrounding countries, have raised concerns about the establishment and re-establishment of these invasive aedes mosquitoes in turkey. this cross-sectional study was performed to detect aedes aegypti and ae. albopictus in regions of recent incursions, and screen for viral pathogens known to be transmitted elsewhere by these species. | 2019 | 31059502 |
| dengue virus: a review on advances in detection and trends - from conventional methods to novel biosensors. | dengue virus is an important arbovirus infection which transmitted by the aedes female mosquitoes. the attempt to control and early detection of this infection is a global public health issue at present. because of the clinical importance of its detection, the main focus of this review is on all of the methods that can offer the new diagnosis strategies. the advantages and disadvantages of reported methods have been discussed comprehensively from different aspects like biomarkers type, sensitivi ... | 2019 | 31055654 |
| evidence for infection but not transmission of zika virus by aedes albopictus (diptera: culicidae) from spain. | a number of mosquito-borne viruses such as dengue virus (denv), usutu virus (usuv), west nile virus (wnv) are autochthonously transmitted in europe and six invasive mosquito species have been detected in this temperate region. this has increased the risk for the emergence of further mosquito-borne diseases. however, there is a paucity of information on whether european populations of invasive mosquito species are competent to transmit arboviruses. in this study, the susceptibility of aedes albop ... | 2019 | 31053164 |