what does heat tell a mosquito? characterization of the orientation behaviour of aedes aegypti towards heat sources.the use of heat as a cue for the orientation of haematophagous insects towards hot-blooded hosts has been acknowledged for many decades. in mosquitoes, thermoreception has been studied at the molecular, physiological and behavioural levels, and the response to heat has been evaluated in multimodal contexts. however, a direct characterization of how these insects evaluate thermal sources is still lacking. in this study we characterize aedes aegypti thermal orientation using a simple dual choice p ...201728479122
eco-friendly synthesis of silver nanoparticles and its larvicidal property against fourth instar larvae of aedes this study, larvicidal activity of silver nanoparticles (agnps) synthesised using apple extract against fourth instar larvae of aedes aegypti was determined. as a result, the agnps showed moderate larvicidal effects against ae. aegypti larvae (lc50 = 15.76 ppm and lc90 = 27.7 ppm). in addition, comparison of larvicidal activity performance of agnps at high concentration prepared using two different methods showed that ae. aegypti larvae was fully eliminated within the duration of 2.5 h. from ...201728476997
photo-induced and phytomediated synthesis of silver nanoparticles using derris trifoliata leaf extract and its larvicidal activity against aedes aegypti.due to the increased development of resistance of vectors against synthetic insecticides and chemical drugs, plant based insecticides serve as promising biocontrol agents for effective vector control. green approach for the synthesis of nanoparticles has been attained using environmentally safe, non-toxic plant extracts. the present study was aimed to investigate the potent larvicidal activity of silver nanoparticles (agnps) produced by derris trifoliata leaf extract in relation to the various c ...201728460330
allergens involved in the cross-reactivity of aedes aegypti with other arthropods.cross-reactivity between aedes aegypti and mites, cockroaches, and shrimp has been previously suggested, but the involved molecular components have not been fully described.201728434865
n-aryl-n'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes.vector control of disease-transmitting mosquitoes by insecticides has a central role in reducing the number of parasitic- and viral infection cases. the currently used insecticides are efficient, but safety concerns and the development of insecticide-resistant mosquito strains warrant the search for alternative compound classes for vector control. here, we have designed and synthesized thiourea-based compounds as non-covalent inhibitors of acetylcholinesterase 1 (ache1) from the mosquitoes anoph ...201728433681
identification of the septate junction protein gliotactin in the mosquito aedes aegypti: evidence for a role in increased paracellular permeability in larvae.septate junctions (sjs) regulate paracellular permeability across invertebrate epithelia. however, little is known about the function of sj proteins in aquatic invertebrates. in this study, a role for the transmembrane sj protein gliotactin (gli) in the osmoregulatory strategies of larval mosquito (aedes aegypti) was examined. differences in gli transcript abundance were observed between the midgut, malpighian tubules, hindgut and anal papillae of a. aegypti, which are epithelia that participate ...201728432154
allatotropin: a pleiotropic neuropeptide that elicits mosquito immune responses.allatotropins (at) are neuropeptides with pleotropic functions on a variety of insect tissues. they affect processes such as juvenile hormone biosynthesis, cardiac rhythm, oviduct and hindgut contractions, nutrient absorption and circadian cycle. the present work provides experimental evidence that at elicits immune responses in two important mosquito disease vectors, anopheles albimanus and aedes aegypti. hemocytes and an immune-competent mosquito cell line responded to at by showing strong mor ...201728426765
efficacy of some wearable devices compared with spray-on insect repellents for the yellow fever mosquito, aedes aegypti (l.) (diptera: culicidae).the current zika health crisis in the americas has created an intense interest in mosquito control methods and products. mosquito vectors of zika are of the genus aedes, mainly the yellow fever mosquito, aedes aegypti. l. the use of repellents to alter mosquito host seeking behavior is an effective method for the prevention of mosquito-borne diseases. a large number of different spray-on repellents and wearable repellent devices are commercially available. the efficacies of many repellents are u ...201728423421
habitat and density of oviposition opportunity influences aedes aegypti (diptera: culicidae) flight distance.understanding the dispersal of aedes (aegypti (l.) diptera: culicidae) after consuming a potentially infectious bloodmeal is an important part of controlling the spread of the arboviruses it transmits. because of the impact on abundance, removal of oviposition sites is a key component of vector control. however, source reduction around a case may encourage dispersal of potentially infected vectors. we compare the effect of oviposition site availability on ae. aegypti dispersal behavior within 30 ...201728419273
the impact of temperature and body size on fundamental flight tone variation in the mosquito vector aedes aegypti (diptera: culicidae): implications for acoustic lures.aedes aegypti (l.) males use female flight tone as a means of mate localization. by playing the sound of a flying female, males can be attracted to a trap to monitor mosquito populations and the progress of transgenic male releases. however, the female flight tone used to attract males needs to be optimized to maximize trap effectiveness. the fundamental frequency of female flight tone could be influenced by both body size and ambient temperature. however, no analysis yet has considered both the ...201728402550
immunohistochemical mapping and transcript expression of the gpa2/gpb5 receptor in tissues of the adult mosquito, aedes aegypti.gpa2/gpb5 is a glycoprotein hormone found in most bilateral metazoans including the mosquito, aedes aegypti. to elucidate physiological roles and functions of gpa2/gpb5, we aim to identify prospective target tissues by examining the tissue- and sex-specific expression profile of its receptor, the leucine-rich repeat-containing g protein-coupled receptor 1 (lgr1) in the adult mosquito. western analyses using a heterologous system with cho-k1 cells, transiently expressing a. aegypti lgr1, yielded ...201728401307
dengue fever outbreaks in eritrea, 2005-2015: a case for strengthening surveillance, control and reporting.the geographic distribution and burden of dengue is increasing globally. this study aims to evaluate dengue outbreaks and to substantiate the need for strengthened surveillance, reporting and control in eritrea.201629202065
phylogenetic analysis of aedes aegypti based on mitochondrial nd4 gene sequences in almadinah, saudi arabia.aedes aegypti is the main vector of the yellow fever and dengue virus. this mosquito has become the major indirect cause of morbidity and mortality of the human worldwide. dengue virus activity has been reported recently in the western areas of saudi arabia. there is no vaccine for dengue virus until now, and the control of the disease depends on the control of the vector.201628959327
knowledge, attitudes, and practices regarding dengue infection among public sector healthcare providers in machala, ecuador.dengue fever is a rapidly emerging infection throughout the tropics and subtropics with extensive public health burden. adequate training of healthcare providers is crucial to reducing infection incidence through patient education and collaboration with public health authorities. we examined how public sector healthcare providers in a dengue-endemic region of ecuador view and manage dengue infections, with a focus on the 2009 world health organization (who) dengue guidelines.201628883952
new state records of mosquitoes for colorado.the 1967 treatment of the mosquitoes of colorado by harmston and lawson and subsequent publications have recorded 46 culicid species from colorado. as part of a study to create an updated synopsis of the mosquitoes of colorado, adult trapping at numerous localities was conducted in colorado during the summers of 2013 and 2014. this review also included an examination of mosquito specimens in various relevant museum collections. aedes (ochlerotatus) niphadopsis and ae. (och.) spencerii spencerii ...201526181688
bioassay and biochemical studies of the status of pirimiphos-methyl and cypermethrin resistance in aedes (stegomyia) aegypti and aedes (stegomyia) albopictus (diptera: culicidae) in singapore.aedes (stegomyia) aegypti (linnaeus) and ae. (stegomyia) albopictus (skuse) were sampled from five regions of singapore (central, north east, north west, south east and south west) and tested with diagnostic concentrations of the technical grade insecticides, pirimiphos-methyl and cypermethrin. biochemical assays were performed on the same populations of ae. aegypti and ae. albopictus to determine activities of detoxifying enzymes, including non-specific esterase (est), monooxygenase (mfo) and a ...201425776592
pre-treatment of stegomyia aegypti mosquitoes with a sublethal dose of imidacloprid impairs behavioural avoidance induced by lemon oil and deet.the present study was conducted to determine whether imidacloprid can impair the avoidance behaviour of the mosquito stegomyia aegypti. laboratory investigations using a t-maze apparatus showed that st. aegypti mosquitoes present long term avoidance behaviour when they are exposed to repetitive trials with lemon oil and deet. the present study tested the effect of a sublethal dose of imidacloprid on the avoidance behaviour of st. aegypti mosquitoes over a 48 h period. data suggest that 0.5 ng of ...201525155403
intra-annual changes in abundance of aedes (stegomyia) aegypti and aedes (ochlerotatus) epactius (diptera: culicidae) in high-elevation communities in mexico.we examined temporal changes in the abundance of the mosquitoes aedes (stegomyia) aegypti (l.) and aedes (ochlerotatus) epactius dyar & knab from june to october 2012 in one reference community at lower elevation (rio blanco; approximately 1,270 m) and three high-elevation communities (acultzingo, maltrata, and puebla city; 1,670-2,150 m) in veracruz and puebla states, méxico. the combination of surveys for pupae in water-filled containers and trapping of adults, using bg-sentinel traps baited w ...201425118405
the importance of oxidases in the tolerance of deciduous leaf infusions by aedes (stegomyia) aegypti and aedes (stegomyia) albopictus (diptera: culicidae).aedes (stegomyia) aegypti (l.) and aedes (stegomyia) albopictus (skuse) larvae rely on oxidases to reduce toxicity of water soluble toxins from some senescent tree leaf infusions. the mortality of third instar ae. aegypti larvae in live oak and pin oak leaf infusions increased significantly in the presence of piperonyl butoxide (pbo), a broad inhibitor of cytochrome p450s (cyps). in contrast, pbo treatment did not increase mortality in water controls or infusions of northern red oak or sugar map ...201424605455
[distribution of aedes (stegomyia) aegypti l. and aedes (stegomyia) albopictus skus. mosquitoes on the black sea coast of the caucasus].there is evidence that in the black sea coastal area, ae.albopictus mosquitoes are encountered everywhere from n. afon to dzhubga over a length of 250 km of the coast and ae.aegypti ones are from n. afon to agoi, tuapse district (215 km). the ae.albopictus mosquitoes have extended 44 km in length and 600 m in height in the eastern part of the coast (krasnaya polyana).201323805493
laboratory and field evaluation of the effects of the neonicotinoid imidacloprid on the oviposition response of aedes (stegomyia) aegypti linnaeus (diptera: culicidae).in this paper, we assessed the suitability of using the neonicotinoid imidacloprid with standard ovitraps by evaluating the ovicidal properties of imidacloprid and its influence on the oviposition response of gravid females of aedes (stegomyia) aegypti linnaeus (diptera: culicidae). first, we calculated the imidacloprid lethal dose 99 (ld(99)) by exposing third instar larvae of the target species to different concentrations of the insecticide. next, ae. aegypti eggs were exposed to the imidaclop ...201122241123
[compared biology of populations of aedes (stegomyia) aegypti (l.) (diptera: culicidae) of paraíba state, brazil].the present work aims at comparing the life cycle and estimating, based on life tables, the patterns of fertility of populations of a. aegypti (l.). the life cycles were studied at the temperature of 26 +/- 2 degrees c, and 12h photophase. the development period, egg viability and larval and pupal survival were evaluated daily as well as adult longevity and fecundity. tables of fertility life were built. the durations of egg, larva and pupa stages varied from 3,9 to 4,5 days, from 6,4 to 8,3 day ...200818368254
the geometry of the wing of aedes (stegomyia) aegypti in isofemale lines through successive generations.under a common laboratory environment, three isofemale lines of aedes (stegomyia) aegypti were used to score metric properties (size and shape) of the wings during 10 generations. since the number of generations was much higher than the number of founders in each line, genetic drift was expected to occur. size tended to slightly increase with time, but its variation among the successive generations did not show any detectable information specific to each line. shape could discriminate among line ...200817600773
biochemical studies of insecticide resistance in aedes (stegomyia) aegypti and aedes (stegomyia) albopictus (diptera: culicidae) in thailand.biochemical analysis was performed on field caught aedes (stegomyia) aegypti and aedes (stegomyia) albopictus (diptera: culicidae) mosquitoes to determine activities of enzymes including mixed function oxidases (mfo), nonspecific esterases (alpha- and beta-), glutathione-s-transferases (gst), and insensitive acetylcholinesterase (ache). biochemical tests were performed on f1 generation of ae. aegypti field caught mosquitoes, while in ae. albopictus f2 progenies were used. twenty-six samples of a ...200717568372
a new larvicidal lignan from piper fimbriulatum.a new lignan, 3,4,5'-trimethoxy-3',4'-methylenedioxy-7,9':7',9 diepoxylignan (1) (6-[4-(3,4-dimethoxy-phenyl)-tetrahydro-furo[3,4-c.]furan-1-yl]-4-methoxy-benzo[ ] dioxole) together with two known lignans, 7'-epi.-sesartemin (2) and diayangambin (3), and a known flavonoid, 5-hydroxy-7,4'-dimethoxyflavone (4), were isolated from the leaves of piper fimbriulatum. c. dc. their structures were assigned by a combination of one- and two-dimensional nmr techniques. 7'-epi.-sesartemin (2) showed the hig ...200528925841
[new and unusual locations of aedes (stegomyia) aegypti, linné 1762 (diptera, culicidae) in madagascar].the author situates and comments three new aedes aegypti's locations in madagascar; one of which is in the international tananarive's airport's control area.19863802312
[the filaria breinlia booliati in the adedes togoi adipose tissue; comparison with the couple dipetalonema dessetae-a. aegypti (author's transl)].in the couple filaria-vector breinlia (breinlia) booliati-aedes (finlaya) togoi, the changs observed in the parasited adipose tissue display large similarities with those recently observed in dipetalonemia (molinema) dessetae-aedes (stegomyia) aegypti: same syncitium organisation of parasited adipocytes, and local stimulation of protein synthesis. however, there is an essential difference between the two coules studied: the parasited adipous syncitium is not any more induced by a blood uptake in ...2007575875
genetic distinctness of sympatric forms of aedes aegypti in east africa. 197928568173
evolutionary strategies in life table characteristics among feral and urban strains of aedes aegypti (l.). 197228555736
reproductive isolation in stegomyia mosquitoes. ii. hybrid breakdown between aedes aegypti and a. mascarensis. 197028564933
the influence of the blood meal type on the fecundity of aedes (stegomyia) aegypti l. (diptera: culicidae). 19705448824
studies on arboviruses and bats (chiroptera) in east africa. i. experimental infection of bats and virus transssion attempts in aedes (stegomyia) aegypti (linnaeus). 19685729255
artificial infection of aedes (stegomyia) aegypti (linnaeus) with five african arboviruses. 19674964631
barriers to hybridization between aedes aegypti and aedes albopictus (diptera: culicidae). 196728556103
laboratory observations on the oviposition habits of aedes (stegomyia) aegypti (linnaeus). 196414212893
[are certain morphological characteristics sufficient to differenciate the varieties of aedes (stegomyia) aegypti linnaeus 1762?importance of the morphological characteristics]. 200614220591
observations on the oviposition-cycle of aedes (stegomyia) aegypti (linnaeus). vi. 196113898644
observations on the oviposition-cycle of aedes (stegomyia) aegypti (linnaeus), v. 196113903448
notes on the mosquitoes and mosquito borne infections of sierra leone. 1. the breeding places of aedes (stegomyia) aegypti in and around freetown. 196013838027
observations on the oviposition-cycle of aedes (stegomyia) aegypti (linnaeus), iv. 196013811896
studies on the biting habits of the mosquito aedes (stegomyia) aegypti, linn., in a west african village. 196013802671
observations on the feeding habits of the mosquito aedes (stegomyia) aegypti (linnaeus): the loss of fluid after a blood-meal and the amount of blood taken during feeding. 196013802674
[appearance of rhythmic contractions on explants of thoracic imaginal disks of larvae of aedes (stegomyia) aegypti (l.) cultivated in vitro]. 201313692106
observations on the oviposition-cycle of aedes (stegomyia) aegypti (linnaeus). iii. 195913850105
laboratory observations on pupation and emergence in the mosquito aedes (stegomyia) aegypti (linnaeus). 195913830752
observations on the ovipositioncycle of aëdes (stegomyia) aegypti (linnaeus), ii. 195913650486
the production of ddt resistance in a southern nigerian strain of aedes (stegomyia) aegypti under laboratory. 195813570011
laboratory studies on the survival of the eggs of aedes (stegomyia) aegypti under adverse conditions. 195813530920
observations on the oviposition-cycle of aëdes (stegomyia) aegypti (linnaeus). 195713445076
initiation and promotion of ovarian development in the mosquito aëdes (stegomyia) aegypti (linnaeus). 195613395327
genetic differences affecting egg-laying in the mosquito aëdes (stegomyia) aegypti (linnaeus). 195613395326
the laboratory transmission of yellow fever by aëdes (stegomyia) aegypti (linnaeus) from malaya. 195514362420
experiments in crossing aedes (stegomyia) aegypti linnaeus and aedes (stegomyia) albopictus skuse. 194917800955
control of stegomyia fasciata (ædes ægypti) mosquitoes in indian country craft by a mosquito-proof metal cap (bennett pattern) for drinking-water receptacles. 193829014217
a practical way of dealing with ædes ægypti (stegomyia fasciata) mosquito breeding in country craft. 193629013069
a practical way of dealing with ædes ægypti (stegomyia fasciata) mosquito breeding in country craft. 193629012997
using maldi-tof ms to identify mosquitoes collected in mali and their blood meals.matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) has been recently described as an innovative and effective tool for identifying arthropods and mosquito blood meal sources. to test this approach in the context of an entomological survey in the field, mosquitoes were collected from five ecologically distinct areas of mali. we successfully analysed the blood meals from 651 mosquito abdomens crushed on whatman filter paper (wfps) in the field using maldi-t ...201829409547
modulation of host learning in aedes aegypti mosquitoes determine which individuals to bite has important epidemiological consequences. this choice is not random; most mosquitoes specialize in one or a few vertebrate host species, and some individuals in a host population are preferred over others. mosquitoes will also blood feed from other hosts when their preferred is no longer abundant, but the mechanisms mediating these shifts between hosts, and preferences for certain individuals within a host species, remain unclear. here, we sho ...201829395917
the spatial and temporal scales of local dengue virus transmission in natural settings: a retrospective analysis.dengue is a vector-borne disease caused by the dengue virus (denv). despite the crucial role of aedes mosquitoes in denv transmission, pure vector indices poorly correlate with human infections. therefore there is great need for a better understanding of the spatial and temporal scales of denv transmission between mosquitoes and humans. here, we have systematically monitored the circulation of denv in individual aedes spp. mosquitoes and human patients from caratinga, a dengue endemic city in th ...201829394906
natural vertical transmission of dengue virus in aedes aegypti and aedes albopictus: a systematic review.dengue is of great concern in various parts of the world, especially in tropical and subtropical countries where the mosquito vectors aedes aegypti and aedes albopictus are present. the transmission of this virus to humans, by what is known as horizontal transmission, occurs through the bite of infected females of one or other of the two mosquito species. furthermore, an infected female or male parent, by what is known as vertical transmission, can transfer this arbovirus to some part of their o ...201829391071
altered vector competence in an experimental mosquito-mouse transmission model of zika infection.few animal models of zika virus (zikv) infection have incorporated arthropod-borne transmission. here, we establish an aedes aegypti mosquito model of zikv infection of mice, and demonstrate altered vector competency among three strains, (orlando, orl, ho chi minh, hcm, and patilas, pat). all strains acquired zikv in their midguts after a blood meal from infected mice, but zikv transmission only occurred in mice fed upon by hcm, and to a lesser extent pat, but not orl, mosquitoes. this defect in ...201829505571
effects of climate change on the spread of zika virus: a public health threat.zika is a vector-borne viral disease transmitted to humans primarily by aedes aegypti mosquitoes. the increased climate instability has contributed to the emergence of infections carried by mosquitoes like dengue, chikungunya and zika. while infection with the zika virus is not new, the recent epidemic of microcephaly in brazil and other countries in south america resulting from the infection of pregnant women with the zika virus raise a number of serious public health concerns. these include th ...201829500926
[zika: probability of establishment of its vector, aedes aegypti, in chile].the zika virus has raised world alarm in recent years, representing a major public health problem. in this study we evaluated the potential risk of exposure to zika virus in chile, associated with the probability of establishment of the vector aedes aegypti in the country. niche modelling techniques were used to project the bioclimatic requirements of the vector (global niches), identifying zones of high suitability for the species within the country. then, the potential distribution of the vect ...201729488548
an overview of mosquito vectors of zika virus.the mosquito-borne arbovirus zika virus (zikv, flavivirus, flaviviridae), has caused an outbreak impressive by its magnitude and rapid spread. first detected in uganda in africa in 1947, from where it spread to asia in the 1960s, it emerged in 2007 on the yap island in micronesia and hit most islands in the pacific region in 2013. subsequently, zikv was detected in the caribbean, and central and south america in 2015, and reached north america in 2016. although zikv infections are in general asy ...201829481868
vector competence of selected north americananophelesandculexmosquitoes for zika virus.zika virus (zikv) is a vector-borne flavivirus that has caused recent outbreaks associated with serious disease in infants and newborns in the americas.aedesmosquitoes are the primary vectors for zikv, but little is known about the diversity of mosquitoes that can transmit zikv in north america. we chose three abundant north american mosquito species (anopheles freeborni,anopheles quadrimaculatus, andculex tarsalis) and one known vector species (aedes aegypti), fed them blood meals supplemented ...201829472998
potential occurrence of zika from subtropical to temperate argentina considering the basic reproduction number (r0).to assess the potential occurrence of zika transmission throughout argentina by the mosquito aedes aegypti considering the basic reproduction number (r0).201829466517
alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on aedes aegypti larvae.aedes aegypti mosquitoes are responsible for dengue, chikungunya, and zika virus transmission in tropical and subtropical areas around the world. due to the absence of vaccines or antiviral drugs for human treatment, the majority of control strategies are targeted at ae. aegypti elimination. our research on mosquito control insecticidal agents has previously shown that the alkaloid girgensohnine and its analogues (α-aminonitriles) present in vitro acetylcholinesterase inhibition and in vivo inse ...201829463410
synergistic effect of entomopathogenic fungus fusarium oxysporum extract in combination with temephos against three major mosquito vectors.mosquito control using chemical insecticides is facing a major challenge due to development of insecticide resistance. improving the efficiency of existing insecticides using synergistic secondary metabolites of biological origin is increasingly being researched. herein, we evaluated the toxicity of fusarium oxysporum extract alone and in binary combinations with temephos, on larvae and pupae of anopheles stephensi, aedes aegypti and culex quinquefaciatus. f. oxysporum extract was characterized ...201829457957
modeling the spread of the zika virus using topological data analysis.zika virus (zikv), a disease spread primarily through the aedes aegypti mosquito, was identified in brazil in 2015 and was declared a global health emergency by the world health organization (who). epidemiologists often use common state-level attributes such as population density and temperature to determine the spread of disease. by applying techniques from topological data analysis, we believe that epidemiologists will be able to better predict how zikv will spread. we use the vietoris-rips fi ...201829438377
integrated vector control of aedes aegypti mosquitoes around target houses.the developing fetuses of pregnant women are at high risk of developing serious birth defects following zika virus infections. we applied an integrated vector control (ivc) approach using source reduction, larviciding, and mass trapping with non-insecticidal sticky traps to protect targeted houses by reducing the density of female aedes aegypti mosquitoes.201829422087
zika and aedes aegypti: new and old challenges.infection with the zika virus had a great impact not only on pregnant women and newborns, but also on public health, on popular ideas about aedes aegypti and with respect to women's social rights. the objective of this paper is to identify this impact and the historical, social and health changes of the disease and the legacy of the zika virus. interventions by researchers from different specialties foster conditions for more comprehensive investigations into future epidemic threats in brazil an ...201829412263
zika virus mb16-23 in mosquitoes, miami-dade county, florida, usa, 2016.we isolated a strain of zika virus, mb16-23, from aedes aegypti mosquitoes collected in miami beach, florida, usa, on september 2, 2016. phylogenetic analysis suggests that mb16-23 most likely originated from the caribbean region.201829400646
mission accomplished? we need a guide to the 'post release' world of wolbachia for aedes-borne disease control.historically, sustained control of aedes aegypti, the vector of dengue, chikungunya, yellow fever, and zika viruses, has been largely ineffective. subsequently, two novel 'rear and release' control strategies utilizing mosquitoes infected with wolbachia are currently being developed and deployed widely. in the incompatible insect technique, male aedes mosquitoes, infected with wolbachia, suppress populations through unproductive mating. in the transinfection strategy, both male and female wolbac ...201829396201
larvicidal activity of selected plant extracts and their combination against the mosquito vectors culex quinquefasciatus and aedes order to develop an environment-friendly botanical mosquito larvicide alternative to the chemical larvicides, extracts were made from the leaves of hyptis suaveolens, lantana camara, nerium oleander, and tecoma stans with three organic solvents such as methanol (me), chloroform (ch), and petroleum ether (pe) using a soxhlet extractor. the plant extracts were screened for larvicidal activity individually and in combination against the larvae of aedes aegypti and culex quinquefasciatus as per w ...201829460245
mosquito saliva: the hope for a universal arbovirus vaccine?arthropod-borne viruses (arboviruses) are taxonomically diverse causes of significant morbidity and mortality. in recent decades, important mosquito-borne viruses such as west nile, chikungunya, dengue, and zika have re-emerged and spread widely, in some cases pandemically, to cause serious public health emergencies. there are no licensed vaccines against most of these viruses, and vaccine development and use has been complicated by the number of different viruses to protect against, by subtype ...201829617849
the potential impacts of 21st century climatic and population changes on human exposure to the virus vector mosquitoaedes aegypti.the mosquitoaedes (ae). aegyptitransmits the viruses that cause dengue and chikungunya, two globally-important vector-borne diseases. we investigate how choosing alternate emissions and/or socioeconomic pathways may modulate future human exposure toae. aegypti. occurrence patterns forae. aegyptifor 2061-2080 are mapped globally using empirically downscaled air temperature and precipitation projections from the community earth system model, for the representative concentration pathway (rcp) 4.5 a ...201829610543
identification of hub genes and pathways in zika virus infection using rna-seq data: a network-based computational approach.zika virus (zikv), a single-strand rna flavivirus, is transmitted primarily through aedes aegypti. the recent outbreaks in america and unexpected association between zikv infection and birth defects have triggered the global attention. this vouches to understand the molecular mechanisms of zikv infection to develop effective drug therapy. a systems-level understanding of biological process affected by zikv infection in fetal brain sample led us to identify the candidate genes for pharmaceutical ...201829608426
pyrethroid resistance persists after ten years without usage against aedes aegypti in governmental campaigns: lessons from são paulo state, brazil.aedes aegypti, vector of dengue, chikungunya and zika viruses, is found at high densities in tropical urban areas. the dissemination of this vector is partially the consequence of failures in current vector control methods, still mainly relying upon insecticides. in the state of são paulo (sp), brazil, public health managers employed pyrethroids against ae. aegypti adults from 1989 to 2000, when a robust insecticide resistance monitoring system detected resistance to pyrethroids in several ae. a ...201829601580
zika virus pathogenesis in infant mice after natural transmission by the bite of infected mosquitoes.the objective of this study was to understand natural disease progression in infant cd1 mice after the bite of aedes aegypti mosquitoes infected by the zika virus (zikv, mr-766 strain).201829597193
commentary: zika virus in the americas-yet anotherarbovirusthreat. 201829593683
diverse laboratory colonies of aedes aegypti harbor the same adult midgut bacterial microbes, collectively known as the microbiota, play an important role in the biology of multicellular organisms. in mosquito vectors of human pathogens, the gut bacterial microbiota influences vectorial capacity and has become the subject of intense study. in laboratory studies of vector biology, genetic effects are often inferred from differences between geographically and genetically diverse colonies of mosquitoes that are reared in the same insectary. it is unclear, however, ...201829587819
a vaccinia-based single vector construct multi-pathogen vaccine protects against both zika and chikungunya viruses.zika and chikungunya viruses have caused major epidemics and are transmitted by aedes aegypti and/or aedes albopictus mosquitoes. the "sementis copenhagen vector" (scv) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified cho cells. herein we describe a single-vector construct scv vaccine that encodes the structural polyprotein cassettes of both zika and chikungunya viruses from different loci. a single vaccination ...201829581442
characterization of the adult aedes aegypti early midgut peritrophic matrix proteome using lc-ms.the aedes aegypti mosquito is the principal vector of arboviruses such as dengue, chikungunya, yellow fever, and zika virus. these arboviruses are transmitted during adult female mosquito bloodfeeding. while these viruses must transverse the midgut to replicate, the blood meal must also reach the midgut to be digested, absorbed, or excreted, as aggregation of blood meal metabolites can be toxic to the female mosquito midgut. the midgut peritrophic matrix (pm), a semipermeable extracellular layer ...201829570734
treatment of chikungunya chronic arthritis: a systematic review.chikungunya (chik) is a tropical arbovirus, transmitted by the female mosquito aedes aegypti and aedes albopictus. in brazil, there have been cases reported since 2014. the initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. usually, chik presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months or even years. during this period, autoimmune diseases can be triggere ...201829561944
model-based inference from multiple dose, time course data reveals wolbachia effects on infection profiles of type 1 dengue virus in aedes aegypti.infection is a complex and dynamic process involving a population of invading microbes, the host and its responses, aimed at controlling the situation. depending on the purpose and level of organization, infection at the organism level can be described by a process as simple as a coin toss, or as complex as a multi-factorial dynamic model; the former, for instance, may be adequate as a component of a population model, while the latter is necessary for a thorough description of the process beginn ...201829558464
mosquito-borne human viral diseases: whyaedes aegypti?although numerous viruses are transmitted by mosquitoes, four have caused the most human suffering over the centuries and continuing today. these are the viruses causing yellow fever, dengue, chikungunya, and zika fevers. africa is clearly the ancestral home of yellow fever, chikungunya, and zika viruses and likely the dengue virus. several species of mosquitoes, primarily in the genusaedes, have been transmitting these viruses and their direct ancestors among african primates for millennia allo ...201829557341
dengue virus infection inaedes albopictusduring the 2014 autochthonous dengue outbreak in tokyo metropolis, 2014 in japan, 162 autochthonous dengue cases were reported for the first time in nearly 70 years. here, we report the results of the detection and isolation of dengue virus (denv) from mosquitoes collected in tokyo metropolis in 2014 and 2015. the phylogenetic relationship among denv isolates from mosquitoes and from patients based on both the entire envelope gene and whole coding sequences was evaluated. herein, 2,298 female and 956 maleaedes albopictusmosquitoes were collected at six suspe ...201829557338
identification of aanat5b as a spermine n-acetyltransferase in the mosquito, aedes aegypti.mosquitoes transmit a number of diseases in animals and humans, including dengue, chikungunya and zika viruses that affect millions of people each year. controlling the disease-transmitting mosquitoes has proven to be a successful strategy to reduce the viruses transmission. polyamines are required for the life cycle of the rna viruses, chikungunya virus and zika virus, and a depletion of spermidine and spermine in the host via induction of spermine n-acetyltransferase restricts their replicatio ...201829554129
the mixture of cashew nut shell liquid and castor oil results in an efficient larvicide against aedes aegypti that does not alter embryo-fetal development, reproductive performance or dna integrity.dengue fever, chikungunya fever and zika virus are epidemics in brazil that are transmitted by mosquitoes, such as aedes aegypti or aedes albopictus. the liquid from shells of cashew nuts is attractive for its important biological and therapeutic activities, which include toxicity to mosquitoes of the genus aedes. the present study evaluated the effects of a mixture of surfactants from natural cashew nutshell liquid and castor oil (named talcc-20) on the mortality of larvae and on the reproducti ...201829554095
mapping the virome in wild-caught aedes aegypti from cairns and bangkok.medically important arboviruses such as dengue, zika, and chikungunya viruses are primarily transmitted by the globally distributed mosquito aedes aegypti. increasing evidence suggests that transmission can be influenced by mosquito viromes. herein rna-seq was used to characterize rna metaviromes of wild-caught ae. aegypti from bangkok (thailand) and from cairns (australia). the two mosquito populations showed a high degree of similarity in their viromes. blast searches of assembled contigs sugg ...201829549363
estimating the probability of dengue virus introduction and secondary autochthonous cases in europe.given the speed of air travel, diseases even with a short viremia such as dengue can be easily exported to dengue naïve areas within 24 hours. we set out to estimate the risk of dengue virus introductions via travelers into europe and number of secondary autochthonous cases as a result of the introduction. we applied mathematical modeling to estimate the number of dengue-viremic air passengers from 16 dengue-endemic countries to 27 european countries, taking into account the incidence of dengue ...201829545610
house screening with insecticide-treated netting provides sustained reductions in domestic populations of aedes aegypti in merida, mexico.there is a need for effective methods to control aedes aegypti and prevent the transmission of dengue, chikungunya, yellow fever and zika viruses. insecticide treated screening (its) is a promising approach, particularly as it targets adult mosquitoes to reduce human-mosquito contact.201829543805
the seasonal influence of climate and environment on yellow fever transmission across africa.yellow fever virus (yfv) is a vector-borne flavivirus endemic to africa and latin america. ninety per cent of the global burden occurs in africa where it is primarily transmitted by aedes spp, with aedes aegypti the main vector for urban yellow fever (yf). mosquito life cycle and viral replication in the mosquito are heavily dependent on climate, particularly temperature and rainfall. we aimed to assess whether seasonal variations in climatic factors are associated with the seasonality of yf rep ...201829543798
risk perception and level of knowledge of diseases transmitted by aedes aegypti.diseases caused by viruses such as dengue, chikungunya and zika are mosquito-borne diseases transmitted by aedes aegypti. we performed a cross-sectional study of healthcare personnel and the general population using questionnaires to identify the level of knowledge, attitudes and practices, and risk perception for dengue, chikungunya and zika. a total of 248 questionnaires were applied, 63.3% to healthcare personnel and 36.7% to the general population. of the healthcare personnel, 53% were men, ...201829538507
dengue virus in aedes aegypti and aedes albopictus in urban areas in the state of rio grande do norte, brazil: importance of virological and entomological surveillance.vector control remains the sole effective method to prevent dengue virus (denv) transmission, although a vaccine for dengue has recently become available and testing of its efficacy and coverage is being performed in multiple places. entomological surveillance is a key factor in alerting authorities to possible outbreaks, but until now natural denv infection of mosquito populations has been scarcely used as an early warning system to monitor fluctuating prevalence of infected mosquitoes. the pur ...201829534105
chikungunya virus: a rheumatologist's perspective.chikungunya virus (chikv) is an arthropod-borne alphavirus, transmitted by aedes aegypti and aedes albopictus mosquitoes. it is responsible for a febrile illness, typically accompanied by maculopapular rash and severe, incapacitating arthralgia. the disease, although generally self-limiting, frequently evolves into a long-lasting, debilitating rheumatic disorder, which shares many clinical features with rheumatoid arthritis (ra). the underlying mechanism by which chikv induces persistent arthrit ...201829533749
comparative phylogeography ofaedesmosquitoes and the role of past climatic change for evolution within africa.the study of demographic processes involved in species diversification and evolution ultimately provides explanations for the complex distribution of biodiversity on earth, indicates regions important for the maintenance and generation of biodiversity, and identifies biological units important for conservation or medical consequence. african and forest biota have both received relatively little attention with regard to understanding their diversification, although one possible mechanism is that ...201829531714
natural variation in resistance to virus infection in dipteran insects.the power and ease ofdrosophilagenetics and the medical relevance of mosquito-transmitted viruses have made dipterans important model organisms in antiviral immunology. studies of virus-host interactions at the molecular and population levels have illuminated determinants of resistance to virus infection. here, we review the sources and nature of variation in antiviral immunity and virus susceptibility in model dipteran insects, specifically the fruit flydrosophila melanogasterand vector mosquit ...201829522475
update: noncongenital zika virus disease cases - 50 u.s. states and the district of columbia, 2016.zika virus is a flavivirus primarily transmitted to humans by aedes aegypti mosquitoes (1). zika virus infections also have been documented through intrauterine transmission resulting in congenital infection; intrapartum transmission from a viremic mother to her newborn; sexual transmission; blood transfusion; and laboratory exposure (1-3). most zika virus infections are asymptomatic or result in mild clinical illness, characterized by acute onset of fever, maculopapular rash, arthralgia, or non ...201829518067
impacts of diurnal temperature and larval density on aquatic development of aedes aegypti.the increasing range of aedes aegypti, vector for zika, dengue, chikungunya, and other viruses, has brought attention to the need to understand the population and transmission dynamics of this mosquito. it is well understood that environmental factors and breeding site characteristics play a role in organismal development and the potential to transmit pathogens. in this study, we observe the impact of larval density in combination with diurnal temperature on the time to pupation, emergence, and ...201829513751
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