Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| an approach of the exact linearization techniques to analysis of population dynamics of the mosquito aedes aegypti. | dengue fever, chikungunya and zika are caused by different viruses and mainly transmitted by aedes aegypti mosquitoes. these diseases have received special attention of public health officials due to the large number of infected people in tropical and subtropical countries and the possible sequels that those diseases can cause. in severe cases, the infection can have devastating effects, affecting the central nervous system, muscles, brain and respiratory system, often resulting in death. vaccin ... | 2017 | 29253493 |
| social-ecological factors and preventive actions decrease the risk of dengue infection at the household-level: results from a prospective dengue surveillance study in machala, ecuador. | in ecuador, dengue virus (denv) infections transmitted by the aedes aegypti mosquito are among the greatest public health concerns in urban coastal communities. community- and household-level vector control is the principal means of controlling disease outbreaks. this study aimed to assess the impact of knowledge, attitudes, and practices (kaps) and social-ecological factors on the presence or absence of denv infections in the household. | 2017 | 29253873 |
| seasonal and spatial quantitative changes in aedes aegypti under distinctly different ecological areas of lahore, pakistan. | to find out the variations in larval and adult density of aedes aegypti in different seasons under different ecological conditions. | 2017 | 29256519 |
| zika virus exhibits lineage-specific phenotypes in cell culture, in aedes aegypti mosquitoes, and in an embryo model. | zika virus (zikv) has quietly circulated in africa and southeast asia for the past 65 years. however, the recent zikv epidemic in the americas propelled this mosquito-borne virus to the forefront of flavivirus research. based on historical evidence, zikv infections in africa were sporadic and caused mild symptoms such as fever, skin rash, and general malaise. in contrast, recent asian-lineage zikv infections in the pacific islands and the americas are linked to birth defects and neurological dis ... | 2017 | 29258204 |
| from ground pools to treeholes: convergent evolution of habitat and phenotype in aedes mosquitoes. | invasive mosquito species are responsible for millions of vector-borne disease cases annually. the global invasive success of aedes mosquitoes such as aedes aegypti and aedes albopictus has relied on the human transport of immature stages in container habitats. however, despite the importance of these mosquitoes and this ecological specialization to their widespread dispersal, evolution of habitat specialization in this group has remained largely unstudied. we use comparative methods to evaluate ... | 2017 | 29258425 |
| origin of a high-latitude population of aedes aegypti in washington, dc. | an overwintering population of aedes aegypti has been documented in the capitol hill neighborhood of washington, dc, since 2011. mitochondrial cytochrome oxidase i (mtcoi) sequence data presented in a previous study traced the origin to the new world. here, we use microsatellite and snp chip data along with more mitochondrial dna (mtdna) sequences on washington ae. aegypti samples and samples from potential sources to further narrow the origin of this population. genetically, washington ae. aegy ... | 2017 | 29260658 |
| assessment of maldi-tof mass spectrometry for filariae detection in aedes aegypti mosquitoes. | matrix assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) is an emerging tool for routine identification of bacteria, archaea and fungi. it has also been recently applied as an accurate approach for arthropod identification. preliminary studies have shown that the maldi-tof ms was able to differentiate whether ticks and mosquitoes were infected or not with some bacteria and plasmodium parasites, respectively. the aim of the present study was to test the efficien ... | 2017 | 29261659 |
| individual co-variation between viral rna load and gene expression reveals novel host factors during early dengue virus infection of the aedes aegypti midgut. | dengue virus (denv) causes more human infections than any other mosquito-borne virus. the current lack of antiviral strategies has prompted genome-wide screens for host genes that are required for denv infectivity. earlier transcriptomic studies that identified denv host factors in the primary vector aedes aegypti used inbred laboratory colonies and/or pools of mosquitoes that erase individual variation. here, we performed transcriptome sequencing on individual midguts in a field-derived ae. aeg ... | 2017 | 29261661 |
| characteristics of aedes aegypti adult mosquitoes in rural and urban areas of western and coastal kenya. | aedes aegypti is the main vector for yellow fever, dengue, chikungunya and zika viruses. recent outbreaks of dengue and chikungunya have been reported in kenya. presence and abundance of this vector is associated with the risk for the occurrence and transmission of these diseases. this study aimed to characterize the presence and abundance of ae. aegypti adult mosquitoes from rural and urban sites in western and coastal regions of kenya. presence and abundance of ae. aegypti adult mosquitoes wer ... | 2017 | 29261766 |
| chikungunya: molecular aspects, clinical outcomes and pathogenesis. | the alarming worldwide emergence of the chikungunya virus began in the last decade. since the first autochthonous transmission in mexico in november of 2014, the virus has spread throughout the country, resulted in multiple outbreaks. this virus produces an acute and self-limiting disease characterized by fever, polyarthralgia, myalgia, exanthema, and general malaise. it is transmitted to humans by the bite of aedes aegypti and a. albopictus mosquitoes. the fact that the clinical presentation is ... | 2017 | 29265115 |
| at the origin of a worldwide invasion: unraveling the genetic makeup of the caribbean bridgehead populations of the dengue vector aedes aegypti. | human-driven global environmental changes have considerably increased the risk of biological invasions, especially the spread of human parasites and their vectors. among exotic species that have major impacts on public health, the dengue fever mosquito aedes aegypti originating from africa has spread worldwide during the last three centuries. although considerable progress has been recently made in understanding the history of this invasion, the respective roles of human and abiotic factors in s ... | 2018 | 29267872 |
| zika virus mosquito vectors: competence, biology, and vector control. | zika virus (zikv) (flaviviridae, flavivirus) has become one of the most medically important mosquito-borne viruses because of its ability to cause microcephaly in utero and guillain-barré syndrome in adults. this virus emerged from its sylvatic cycle in africa to cause an outbreak in yap, federated states of micronesia in 2007, french polynesia in 2014, and most recently south america in 2015. the rapid expansion of zikv in the americas largely has been due to the biology and behavior of its vec ... | 2017 | 29267910 |
| history and emergence of zika virus. | zika virus was discovered in east africa in 1947 by the rockefeller foundation during investigations on the ecology of yellow fever. although it was subsequently shown to have widespread distribution in africa and asia, it was not known to cause epidemics until 2007. this paper describes the history of the virus discovery, emergence and evolution as an epidemic virus, and the its evolving clinical spectrum. | 2017 | 29267917 |
| zika virus: an emerging infectious disease with serious perinatal and neurologic complications. | zika virus (zikv) is a flavivirus that is primarily transmitted by aedes aegypti, the mosquito vector also important in the transmission of the flaviviruses responsible for dengue fever, yellow fever and chikungunya. due to occurrence in the same geographic regions, serological cross-reactivity, and similar, albeit often less severe clinical manifestations as dengue and chikungunya infections, zikv infection likely went undetected and/or misdiagnosed for many years. zikv is somewhat unique among ... | 2017 | 29273403 |
| altitudinal distribution of aedes indices during dry season in the dengue endemic area of central java, indonesia | aedes mosquitoes, mainly aedes aegypti and aedes albopictus, are the primary and secondary vectors of dengue viruses in indonesia, with transmission occurring by sucking blood. the density of the vectors is influenced by season and rainfall, but limited by altitude. the aim of the study is to describe the density and distribution of dengue vectors during the dry season based on the altitudes of recent dengue cases in five regencies of central java province, indonesia. mosquito larvae and pupae w ... | 2017 | 29274215 |
| field- and clinically derived estimates of wolbachia-mediated blocking of dengue virus transmission potential in aedes aegypti mosquitoes. | the wmel strain of wolbachia can reduce the permissiveness of aedes aegypti mosquitoes to disseminated arboviral infections. here, we report that wmel-infected ae. aegypti (ho chi minh city background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (denv) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. the wmel-infected mosquitoes that are field-reared have even greater relative resistance to denv infection ... | 2018 | 29279375 |
| african and asian zika virus isolates display phenotypic differences both in vitro and in vivo. | zika virus (zikv) is a mosquito-borne member of the genus flavivirus that has emerged since 2007 to cause outbreaks in africa, asia, oceania, and most recently, in the americas. here, we used an isolate history as well as genetic and phylogenetic analyses to characterize three low-passage isolates representing african (ard 41525) and asian (cpc-0740, sv0127-14) lineages to investigate the potential phenotypic differences in vitro and in vivo. the african isolate displayed a large plaque phenotyp ... | 2017 | 29280428 |
| family level variation in wolbachia-mediated dengue virus blocking in aedes aegypti. | the mosquito vector aedes aegypti is responsible for transmitting a range of arboviruses including dengue (denv) and zika (zikv). the global reach of these viruses is increasing due to an expansion of the mosquito's geographic range and increasing urbanization and human travel. vector control remains the primary means for limiting these diseases. wolbachia pipientis is an endosymbiotic bacterium of insects that has the ability to block the replication of pathogens, including flaviviruses such as ... | 2017 | 29282144 |
| genetically modified aedes aegypti to control dengue: a review. | dengue is an acute infectious disease of viral etiology characterized by lymphadenopathy, leucopenia, headache, biphasic fever, pain in various parts of the body, rashes, and extreme physical weakness. it is a vector-borne disease caused by a positive-stranded rna virus of the family flaviviridae, genus flavivirus. dengue inflicts a significant health, economic, and social burden on populations of endemic areas. dengue virus is transmitted to humans by the mosquito vector aedes aegypti. vaccines ... | 2017 | 29283327 |
| dengue and yellow fever virus vectors: seasonal abundance, diversity and resting preferences in three kenyan cities. | the transmission patterns of dengue (denv) and yellow fever (yfv) viruses, especially in urban settings, are influenced by aedes (stegomyia) mosquito abundance and behavior. despite recurrent dengue outbreaks on the kenyan coast, these parameters remain poorly defined in this and other areas of contrasting dengue endemicity in kenya. in assessing the transmission risk of denv/yfv in three kenyan cities, we determined adult abundance and resting habits of potential aedes (stegomyia) vectors in ki ... | 2017 | 29284522 |
| n-substituted methyl maleamates as larvicidal compounds against aedes aegypti (diptera: culicidae). | severe human arboviral diseases can be transmitted by the mosquito aedes aegypti (l.), including dengue, chikungunya, zika, and yellow fever. the use of larvicides in containers that can result as potential breeding places and cannot be eliminated is the main alternative in control programs. however, their continuous and widespread use caused an increase in insecticide-resistant populations of this mosquito. the aim of this study was to evaluate the effect of three n-substituted methyl maleamate ... | 2018 | 29290037 |
| insecticide treated curtains and residual insecticide treatment to control aedes aegypti: an acceptability study in santiago de cuba. | within the context of a field trial conducted by the cuban vector control program (aacp), we assessed acceptability of insecticide-treated curtains (itcs) and residual insecticide treatment (rit) with deltamethrin by the community. we also assessed the potential influence of interviewees' risk perceptions for getting dengue and disease severity. | 2018 | 29293501 |
| zika virus infection modulates the bacterial diversity associated with aedes aegypti as revealed by metagenomic analysis. | zika is a re-emerging infection that has been considered a major threat to global public health. currently at least 100 countries are at risk of zika virus (zikv) transmission. aedes aegypti is the main mosquito vector in the americas. this vector is exposed to, and interacts symbiotically with a variety of microorganisms in its environment, which may result in the formation of a lifetime association. here, the unknown effect that zikv exerts on the dynamic bacterial community harbored by this m ... | 2018 | 29293631 |
| group b wolbachia strain-dependent inhibition of arboviruses. | mosquito-borne viruses, including zika virus (zikv) and dengue virus (denv), are global threats that continue to infect millions annually. historically, efforts to combat the spread of these diseases have sought to eradicate the mosquito population. this has had limited success. recent efforts to combat the spread of these diseases have targeted the mosquito population and the mosquito's ability to transmit viruses by altering the mosquito's microbiome. the introduction of particular strains of ... | 2018 | 29297702 |
| hypoxia-induced transcription factor signaling is essential for larval growth of the mosquito aedes aegypti. | gut microbes positively affect the physiology of many animals, but the molecular mechanisms underlying these benefits remain poorly understood. we recently reported that bacteria-induced gut hypoxia functions as a signal for growth and molting of the mosquito aedes aegypti in this study, we tested the hypothesis that transduction of a gut hypoxia signal requires hypoxia-induced transcription factors (hifs). expression studies showed that hif-α was stabilized in larvae containing bacteria that in ... | 2018 | 29298915 |
| assessment of a trap based aedes aegypti surveillance program using mathematical modeling. | the goal of this study was to assess the goodness-of-fit of theoretical models of population dynamics of aedes aegypti to trap data collected by a long term entomological surveillance program. the carrying capacity k of this vector was estimated at city and neighborhood level. adult mosquito abundance was measured via adults collected weekly by a network of sticky traps (mosquitraps) from january 2008 to december 2011 in vitória, espírito santo, brazil. k was the only free parameter estimated by ... | 2018 | 29304070 |
| synergistic effect of fertilizer and plant material combinations on the development of aedes aegypti (diptera: culicidae) and anopheles gambiae (diptera: culicidae) mosquitoes. | chemical fertilizers are used everywhere, which often pollute the breeding sites of mosquitoes. in this laboratory study, the consequences on aedes aegypti (l.) (diptera: culicidae) and anopheles gambiae (giles) (diptera: culicidae) of water-containing plant matter (pm) alone, or in association with an npk type of fertilizer (pm+npk), were evaluated. to obtain a 20% imaginal emergence of an. gambiae (iet20), the bioassays carried out with pm have evidenced that its larvae need four times as much ... | 2017 | 29309617 |
| critical low temperature for the survival of aedes aegypti in taiwan. | taiwan is geographically located in a region that spans both tropical and subtropical climates (22-25°n and 120-122°e). the taiwan centers for disease control have found that the ecological habitat of aedes aegypti appears only south of 23.5°n. low temperatures may contribute to this particular habitat distribution of ae. aegypti under the influence of the east asian winter monsoon. however, the threshold condition related to critically low temperatures remains unclear because of the lack of lar ... | 2018 | 29310716 |
| the genomes of four meyerozymacaribbica isolates and novel insights into the meyerozymaguilliermondii species complex. | yeasts of the meyerozyma guilliermondii species complex are widespread in nature and can be isolated from a variety of sources, from the environment to arthropods to hospital patients. to date, the species complex comprises the thoroughly studied and versatile m. guilliermondii, and the hard to distinguish m. caribbica, and candida carpophila here we report the whole-genome sequencing and de novo assembly of four m. caribbica isolates, identified with the most recent molecular techniques, derive ... | 2018 | 29311113 |
| aristololactam derivatives from the fruits of aristolochia contorta bunge. | three new aristololactam derivatives, aristololactam w-y (1-3), and three known compounds (4-6) were isolated from the fruits of aristolochia contorta bunge. compounds 1 and 2 represent the first example of an n-ch2och3 aristololactam derivative from natural products. their structures were elucidated by 1d/2d nmr and hresims spectra. all of the isolated compounds were evaluated for their insecticidal activity against 4th instar larvae of aedes aegypti. compound 4 displayed insecticidal activity ... | 2018 | 29313366 |
| krüppel homologue 1 acts as a repressor and an activator in the transcriptional response to juvenile hormone in adult mosquitoes. | krüppel homologue 1 (kr-h1) is a zinc finger transcription factor that is upregulated in insects by juvenile hormone (jh) in metamorphosis and adult reproduction. the molecular function of kr-h1 in reproduction remains largely unknown. here we report that aakr-h1 functions as an important transcription regulator in adult female aedes aegypti mosquitoes. the amount of aakr-h1 protein increases with rising jh levels after adult emergence, reaches its peak at 48 h after eclosion, then decreases gra ... | 2018 | 29314423 |
| qsar analysis of plant-derived compounds with larvicidal activity against zika aedes aegypti (diptera: culicidae) vector using freely available descriptors. | we develop a qsar model for predicting the larvicidal activity of 60 plant-derived molecules against aedes aegypti l. (diptera: culicidae), vector of several diseases such as, dengue, yellow fever, chikungunya and zika virus. the balanced subsets method (bsm) based on k-means cluster analysis (k-mca) is employed to split the data set. the replacement method (rm) variable subset selection technique coupled with multivariable linear regression (mlr) proves to be successful for exploring 18,326 mol ... | 2018 | 29314584 |
| dengue hemorrhagic fever virus in saudi arabia: a review. | dengue fever is a global disease with a spectrum of clinical manifestation ranging from mild febrile disease to a severe disease in the form of dengue hemorrhagic fever and dengue shock syndrome. dengue virus is one viral hemorrhagic fever that exists in the kingdom of saudi arabia in addition to alkhurma (alkhurma) hemorrhagic fever, chikungunya virus, crimean-congo hemorrhagic fever, and rift valley fever. the disease is limited to the western and south-western regions of saudi arabia, where a ... | 2018 | 29319426 |
| citrus seed oils efficacy against larvae of aedes aegypti. | dengue fever is a serious public health issue in pakistan for many years. globally plants have been reported to contain compounds with insecticidal properties. these properties have been demonstrated more recently on the larval stages of mosquitoes. therefore, citrus cultivar seeds were evaluated for larvicidal potential against the primary dengue vector aedes aegypti. | 2017 | 29322059 |
| the discovery of arthropod-specific viruses in hematophagous arthropods: an open door to understanding the mechanisms of arbovirus and arthropod evolution? | the discovery of an odd virus from hematophagous arthropods 40 years ago by stollar and thomas described cell fusing agent virus in cells derived from aedes aegypti mosquitoes. then came the report of kamiti river virus from ae. macintoshi in 1999, followed by worldwide reports of the discovery of other viruses of mosquitoes, ticks, and midges that replicate only in arthropods and not in vertebrates or in vertebrate cells. these viruses (now totaling at least 64 published) have genomes analogous ... | 2018 | 29324047 |
| genome sequence of a novel strain of a phasi charoen-like virus identified in zhanjiang, china. | here, we report the genome sequence of a novel strain of a phasi charoen-like virus, isolated from aedes aegypti mosquitoes caught in zhanjiang province of china. phylogenetic analysis suggested that this virus belongs to a new genus, goukovirus, in the family bunyaviridae this is the first reported genome sequence of a phasi charoen-like virus identified in china. | 2018 | 29326198 |
| vibrational properties of bulk boric acid 2a and 3t polymorphs and their two-dimensional layers: measurements and density functional theory calculations. | boric acid (h3bo3) is being used effectively nowadays in traps/baits for the management of aedes aegypti l. and aedes albopictus skuse species of mosquitoes, which are the main spreading vectors worldwide for diseases such as malaria, dengue, and zika. previously, we published results on the structural, electronic, and optical properties of its molecular triclinic h3bo3-2a and trigonal h3bo3-3t polymorphs within the framework of density functional theory (dft). because of the renewed importance ... | 2018 | 29328646 |
| wolbachia-induced transcription factor gata4 suppresses ovary-specific genes blastoderm-specific protein 25d and imaginal disc growth factor. | the endosymbiotic bacterium wolbachia infects a wide array of insect hosts and has been implicated in a range of biological modifications as a consequence of its infection. previously, it was shown that the transcription factor gata4 was significantly induced in wolbachia wmelpop-cla strain infected aedes aegypti whole mosquitoes and cells. here, we provide evidence that this induction also occurs in mosquito ovaries where the ovary-specific genes blastoderm-specific protein 25d (bsg25d) and ima ... | 2018 | 29336504 |
| zika virus in salivary glands of five different species of wild-caught mosquitoes from mexico. | zika virus (zikv) is a mosquito-borne pathogen, and aedes aegypti has been identified as the main vector of the disease. other mosquito species in the aedes and culex genera have been suggested to have the potential for being competent vectors based on experimental exposition of mosquitoes to an infectious blood meal containing zikv. here, we report the isolation in cell culture of zikv obtained from different body parts of wild-caught female mosquitoes (ae. aegypti, ae. vexans, cx. quinquefasci ... | 2018 | 29339746 |
| reduction in musca domestica fecundity by dsrna-mediated gene knockdown. | house flies (musca domestica) are worldwide agricultural pests with estimated control costs at $375 million annually in the u.s. non-target effects and widespread resistance challenge the efficacy of traditional chemical control. double stranded rna (dsrna) has been suggested as a biopesticide for m. domestica but a phenotypic response due to the induction of the rnai pathway has not been demonstrated in adults. in this study female house flies were injected with dsrna targeting actin-5c or ribo ... | 2018 | 29342168 |
| aerial ulv control of aedes aegypti with naled (dibrom) inside simulated rural village and urban cryptic habitats. | we conducted aerial fixed wing ultra low volume (ulv) spray trials with naled to investigate penetration of exposed and simulated cryptic habitat within opened buildings, partially sealed buildings, and outdoor locations targeting sentinel adult aedes aegypti mosquitoes in north central florida. mortality was observed in open and closed buildings and outdoors, even in mosquitoes placed in cryptic habitats. observations on the impact of building type, mosquito exposure method such as placement in ... | 2018 | 29352307 |
| current concerns and perspectives on zika virus co-infection with arboviruses and hiv. | dissemination of vector-borne viruses, such as zika virus (zikv), in tropical and sub-tropical regions has a complicated impact on the immunopathogenesis of other endemic viruses such as dengue virus (denv), chikungunya virus (chikv) and human immunodeficiency virus (hiv). the consequences of the possible co-infections with these viruses have specifically shown significant impact on the treatment and vaccination strategies. zikv is a mosquito-borne flavivirus from african and asian lineages that ... | 2018 | 29352633 |
| fine-scale landscape genomics helps explain the slow spatial spread of wolbachia through the aedes aegypti population in cairns, australia. | the endosymbiotic bacterium wolbachia suppresses the capacity for arbovirus transmission in the mosquito aedes aegypti, and can spread spatially through wild mosquito populations following local introductions. recent introductions in cairns, australia have demonstrated slower than expected spatial spread. potential reasons for this include: (i) barriers to ae. aegypti dispersal; (ii) higher incidence of long-range dispersal; and (iii) intergenerational loss of wolbachia. we investigated these th ... | 2018 | 29358725 |
| persistence of toxic activity of fermentation extracts from bacillus thuringiensis var. israelensis after more than three decades of storage. | this study was carried out to determine the persistence of toxicity of fermentation extracts of bacillus thuringiensis var. israelensis after more than three decades of storage. for this purpose, a population of aedes aegypti was established. the mortality rate of 20 spore-crystal extracts purified using the acetone-lactose coprecipitation method was measured and evaluated by bioassays according to a modified who protocol. the extracts with the highest mortality rate were determined in triplicat ... | 2017 | 29358951 |
| cytoplasmic glutamine synthetase gene expression regulates larval development in bactrocera dorsalis (hendel). | in insects, glutamine synthetase (gs), a key enzyme in the synthesis of glutamine, has been reported to be associated with embryonic development, heat shock response, and fecundity regulation. however, little is known about the influence of gs on postembryonic development. in this study, we demonstrate that blocking the activity of gs in the oriental fruit fly (bactrocera dorsalis) with use of a gs-specific inhibitor (l-methionine s-sulfoximine), led to a significant delay in larval development, ... | 2018 | 29359358 |
| [dengue, zika, chikungunya and the development of vaccines]. | dengue (denv), zika (zikv) and chikungunya (chikv), three arbovirosis transmitted by aedes mosquitoes, have spread in recent decades in humid tropical and subtropical zones. dengue is epidemic in subtropical areas of argentina. denv infection confers lasting immunity against the infecting serotype but increases the risk of serious disease upon reinfection by any of the other three. the recombinant tetravalent vaccine dengvaxia® prevents severe dengue and hospitalization in seropositive subjects. ... | 2018 | 29360072 |
| larvicidal activity against aedes aegypti and chemical characterization of the inflorescences of tagetes patula. | the crude acetone extract (cae) of defatted inflorescences of tagetes patula was partitioned into five semipurified fractions: n-hexane (hf), dichloromethane (df), ethyl acetate (eaf), n-butanol (bf), and aqueous (aqf). bf was fractionated by reversed-phase polyamide column chromatography, obtaining 34 subfractions, which were subjected to hsccc, where patuletin and patulitrin were isolated. cae and the fractions bf, eaf, df, and aqf were analyzed by lc-dad-ms, and patuletin and patulitrin were ... | 2017 | 29362590 |
| multifaceted functional implications of an endogenously expressed trna fragment in the vector mosquito aedes aegypti. | the mosquito aedes aegypti is the primary vector of human arboviral diseases caused by dengue, chikungunya and zika viruses. many studies have shown the potential roles of small rna molecules such as microrna, small interfering rna and piwi-interacting rna in vector mosquitoes. the function of trna fragments (trf), the newly discovered class of small rnas, in mosquitoes is not known. in this study, we show that specific trfs are expressed in significantly differential manner between males and fe ... | 2018 | 29364883 |
| relative insecticidal efficacy of three spatial repellent integrated light sources against aedes aegypti. | three repellent products, off! mosquito lamp, insecticandel, and rescue decoshield, were comparatively evaluated against aedes aegypti in 130-m2 enclosed areas with a 317-m3 air volume. the results showed that the off! mosquito lamp with metofluthrin had a greater effect than the insecticandel with transfluthrin, which had greater effect than the decoshield with lemongrass oil and several other plant oils against ae. aegypti. the off! mosquito lamp was the only product to exceed 50% mortality. a ... | 2017 | 29369020 |
| laboratory evaluation of synthetic blends of l-(+)-lactic acid, ammonia, and ketones as potential attractants for aedes aegypti. | attraction of aedes aegypti to various binary, trinary, and quaternary blends of lactic acid and ketones with or without ammonia was studied using a dual choice olfactometer. a dose dependent attraction was observed in cases of single compounds where cyclopentanone attracted the highest percentage (36.9 ± 1.8%) of ae. aegypti when tested alone. no significant difference was observed between the attraction levels of trinary and binary blends of lactic acid and acetone or butanone when tested agai ... | 2017 | 29369028 |
| bg-sentinel™ trap efficacy as a component of proof-of-concept for push-pull control strategy for dengue vector mosquitoes. | the efficacy of the bg-sentinel™ (bgs) trap as a "pull" component of a "push-pull" system (pps) for management of the dengue vector, aedes aegypti, was evaluated using local households in pu tuey, kanchanaburi, thailand. the pull component was the concluding phase of a 3-part investigation using a pps combination spatial repellent (sr) and bgs trap to capture adult vector mosquitoes. two sentinel households were selected for evaluation of bgs trap efficacy based on the highest pretrial indoor re ... | 2017 | 29369029 |
| comparison of adult mosquito abundance from biogents-2 sentinel and biogents gravid aedes traps in northeastern florida. | we compared the efficacy of the biogents gravid aedes trap (bg-gat) and biogents-2 sentinel (bg2s) trap to assess differences in adult mosquito collection rates between these 2 mosquito surveillance methods in northeastern florida. species diversity of trap collections was significantly greater for bg2s than for bg-gat, with 14 mosquito species collected from the former trap and 4 species from the latter. aedes aegypti and culex quinquefasciatus were the 2 predominant species collected in both t ... | 2017 | 29369031 |
| a small-scale investigation into the effect of a larvicidal oil on oviposition site preference by aedes aegypti. | larvicidal oils can be used to control immature aedes aegypti and other pestiferous mosquitoes. to test whether oil-based larvicides also act as oviposition deterrents, indoor and semi-field trials were conducted at the navy entomology center of excellence in jacksonville, fl. in both studies, treatment cages consisted of oviposition cups lined with seed germination paper as an oviposition substrate and filled with 1-wk-old southern live oak ( quercus virginiana) leaf litter-infused water. treat ... | 2017 | 29369032 |
| the wolbachia strain wau provides highly efficient virus transmission blocking in aedes aegypti. | introduced transinfections of the inherited bacteria wolbachia can inhibit transmission of viruses by aedes mosquitoes, and in ae. aegypti are now being deployed for dengue control in a number of countries. only three wolbachia strains from the large number that exist in nature have to date been introduced and characterized in this species. here novel ae. aegypti transinfections were generated using the walba and wau strains. in its native ae. albopictus, walba is maintained at lower density tha ... | 2018 | 29370307 |
| [estimation of underreporting of chikungunya virus infection cases in girardot, colombia, from november, 2014, to may, 2015]. | chikungunya virus infection in colombia became epidemic in 2015. it is estimated that there is underreporting of cases to the public health surveillance system which can induce bias in epidemiological projections for decision making, a serious problem, as it veils the real magnitude and actual epidemiological importance of this disease. | 2017 | 29373771 |
| mosquito vector-associated microbiota: metabarcoding bacteria and eukaryotic symbionts across habitat types in thailand endemic for dengue and other arthropod-borne diseases. | vector-borne diseases are a major health burden, yet factors affecting their spread are only partially understood. for example, microbial symbionts can impact mosquito reproduction, survival, and vectorial capacity, and hence affect disease transmission. nonetheless, current knowledge of mosquito-associated microbial communities is limited. to characterize the bacterial and eukaryotic microbial communities of multiple vector species collected from different habitat types in disease endemic areas ... | 2018 | 29375803 |
| meta-analysis of aedes aegypti expression datasets: comparing virus infection and blood-fed transcriptomes to identify markers of virus presence. | the mosquito aedes aegypti (l.) is vector of several arboviruses including dengue, yellow fever, chikungunya, and more recently zika. previous transcriptomic studies have been performed to elucidate altered pathways in response to viral infection. however, the intrinsic coupling between alimentation and infection were unappreciated in these studies. feeding is required for the initial mosquito contact with the virus and these events are highly dependent. addressing this relationship, we reinterr ... | 2017 | 29376049 |
| aedes mosquitoes and aedes-borne arboviruses in africa: current and future threats. | the zika crisis drew attention to the long-overlooked problem of arboviruses transmitted byaedesmosquitoes in africa. yellow fever, dengue, chikungunya and zika are poorly controlled in africa and often go unrecognized. however, to combat these diseases, both in africa and worldwide, it is crucial that this situation changes. here, we review available data on the distribution of each disease in africa, theiraedesvectors, transmission potential, and challenges and opportunities foraedescontrol. d ... | 2018 | 29382107 |
| immune response-related genes associated to blocking midgut dengue virus infection in aedes aegypti strains that differ in susceptibility. | aedes (stegomyia) aegypti, the principal global vector of dengue viruses, has differences in its' susceptibility to dengue virus infection. we compared the global expression of genes in the midguts of colombian ae. aegypti dengue-susceptible (cali-s) and dengue-refractory (cali-mib) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (denv-2). microarray-based transcriptome analysis among treatments indicated a total of 4725 tr ... | 2018 | 29389079 |
| natural vertical transmission of dengue virus in aedes aegypti and aedes albopictus: a systematic review. | dengue is of great concern in various parts of the world, especially in tropical and subtropical countries where the mosquito vectors aedes aegypti and aedes albopictus are present. the transmission of this virus to humans, by what is known as horizontal transmission, occurs through the bite of infected females of one or other of the two mosquito species. furthermore, an infected female or male parent, by what is known as vertical transmission, can transfer this arbovirus to some part of their o ... | 2018 | 29391071 |
| molecular identification, transcript expression, and functional deorphanization of the adipokinetic hormone/corazonin-related peptide receptor in the disease vector, aedes aegypti. | the recently discovered adipokinetic hormone/corazonin-related peptide (acp) is an insect neuropeptide structurally intermediate between corazonin (crz) and adipokinetic (akh) hormones, which all demonstrate homology to the vertebrate gonadotropin-releasing hormone (gnrh). to date, the function of the acp signaling system remains unclear. in the present study, we molecularly identified the complete open reading frame encoding the aedes aegypti acp receptor (acpr), which spans nine exons and unde ... | 2018 | 29391531 |
| the spatial and temporal scales of local dengue virus transmission in natural settings: a retrospective analysis. | dengue is a vector-borne disease caused by the dengue virus (denv). despite the crucial role of aedes mosquitoes in denv transmission, pure vector indices poorly correlate with human infections. therefore there is great need for a better understanding of the spatial and temporal scales of denv transmission between mosquitoes and humans. here, we have systematically monitored the circulation of denv in individual aedes spp. mosquitoes and human patients from caratinga, a dengue endemic city in th ... | 2018 | 29394906 |
| modulation of host learning in aedes aegypti mosquitoes. | how mosquitoes determine which individuals to bite has important epidemiological consequences. this choice is not random; most mosquitoes specialize in one or a few vertebrate host species, and some individuals in a host population are preferred over others. mosquitoes will also blood feed from other hosts when their preferred is no longer abundant, but the mechanisms mediating these shifts between hosts, and preferences for certain individuals within a host species, remain unclear. here, we sho ... | 2018 | 29395917 |
| mission accomplished? we need a guide to the 'post release' world of wolbachia for aedes-borne disease control. | historically, sustained control of aedes aegypti, the vector of dengue, chikungunya, yellow fever, and zika viruses, has been largely ineffective. subsequently, two novel 'rear and release' control strategies utilizing mosquitoes infected with wolbachia are currently being developed and deployed widely. in the incompatible insect technique, male aedes mosquitoes, infected with wolbachia, suppress populations through unproductive mating. in the transinfection strategy, both male and female wolbac ... | 2018 | 29396201 |
| existing and potential infection risk zones of yellow fever worldwide: a modelling analysis. | yellow fever cases are under-reported and the exact distribution of the disease is unknown. an effective vaccine is available but more information is needed about which populations within risk zones should be targeted to implement interventions. substantial outbreaks of yellow fever in angola, democratic republic of the congo, and brazil, coupled with the global expansion of the range of its main urban vector, aedes aegypti, suggest that yellow fever has the propensity to spread further internat ... | 2018 | 29398634 |
| zika virus mb16-23 in mosquitoes, miami-dade county, florida, usa, 2016. | we isolated a strain of zika virus, mb16-23, from aedes aegypti mosquitoes collected in miami beach, florida, usa, on september 2, 2016. phylogenetic analysis suggests that mb16-23 most likely originated from the caribbean region. | 2018 | 29400646 |
| context-dependent interactive effects of non-lethal predation on larvae impact adult longevity and body composition. | predation impacts development, behavior and morphology of prey species thereby shaping their abundances, distribution and community structure. non-lethal threat of predation, specifically, can have a strong influence on prey lifehistory characteristics. while investigations often focus on the impact of predation threat on prey in isolation, tests of its interactive effects with food availability and resource competition on prey survival and fitness can improve understanding of costs, benefits an ... | 2018 | 29401513 |
| aedes aegypti antiviral adaptive response against denv-2. | priming is the conceptual term defining memory phenomenon in innate immune response. numerous examples of enhanced secondary immune response have been described in diverse taxa of invertebrates; which naturally lacks memory response. in mosquitoes, a previous non-lethal challenge with some specific pathogens modify their immune response against the same microorganism; developing an improved antimicrobial reaction. in this work, we explore the ability of aedes aegypti to mount a higher antiviral ... | 2018 | 29408269 |
| using maldi-tof ms to identify mosquitoes collected in mali and their blood meals. | matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) has been recently described as an innovative and effective tool for identifying arthropods and mosquito blood meal sources. to test this approach in the context of an entomological survey in the field, mosquitoes were collected from five ecologically distinct areas of mali. we successfully analysed the blood meals from 651 mosquito abdomens crushed on whatman filter paper (wfps) in the field using maldi-t ... | 2018 | 29409547 |
| zika and aedes aegypti: new and old challenges. | infection with the zika virus had a great impact not only on pregnant women and newborns, but also on public health, on popular ideas about aedes aegypti and with respect to women's social rights. the objective of this paper is to identify this impact and the historical, social and health changes of the disease and the legacy of the zika virus. interventions by researchers from different specialties foster conditions for more comprehensive investigations into future epidemic threats in brazil an ... | 2018 | 29412263 |
| [eradication of aedes aegypti: new perspectives on international health cooperation in the americas]. | 2018 | 29412266 | |
| clinical and epidemiological teaching of dengue through simulated practice. | to describe the experience of clinical teaching on dengue and the practice of epidemiological surveillance using problematization methodology. | 2018 | 29412306 |
| the influence of a light and dark cycle on the egg laying activity of aedes aegypti (linnaeus, 1762) (diptera: culicidae). | the epidemiological importance of the mosquito aedes aegypti as a vector of multiple human pathogens has generated a growing number of studies on the physiology and behaviour of its blood-feeding females. the activity of oviposition is one of the critical elements contributing to the expansion of ae. aegypti's populations. although there is a vast literature about oviposition behaviour, significant specific knowledge about egg viability and female fertility under light and dark conditions is sti ... | 2018 | 29412343 |
| entomopathogenic fungi and their potential for the management of aedes aegypti (diptera: culicidae) in the americas. | classical biological control has been used extensively for the management of exotic weeds and agricultural pests, but never for alien insect vectors of medical importance. this simple but elegant control strategy involves the introduction of coevolved natural enemies from the centre of origin of the target alien species. aedes aegypti - the primary vector of the dengue, yellow fever and zika flaviviruses - is just such an invasive alien in the americas where it arrived accidentally from its west ... | 2018 | 29412361 |
| re-emergence of aedes aegypti in egypt. | 2018 | 29412959 | |
| evidence for chikungunya and dengue transmission in quelimane, mozambique: results from an investigation of a potential outbreak of chikungunya virus. | in january 2016, health authorities from zambézia province, mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an igm-based rapid diagnostic test (rdt). we initiated a study to investigate a potential chikungunya outbreak in the city of quelimane. | 2018 | 29415070 |
| integrated vector control of aedes aegypti mosquitoes around target houses. | the developing fetuses of pregnant women are at high risk of developing serious birth defects following zika virus infections. we applied an integrated vector control (ivc) approach using source reduction, larviciding, and mass trapping with non-insecticidal sticky traps to protect targeted houses by reducing the density of female aedes aegypti mosquitoes. | 2018 | 29422087 |
| a natural agonist of mosquito trpa1 from the medicinal plant cinnamosma fragrans that is toxic, antifeedant, and repellent to the yellow fever mosquito aedes aegypti. | plants produce various secondary metabolites that offer a potential source of novel insecticides and repellents for the control of mosquito vectors. plants of the genus cinnamosma are endemic to, and widely-distributed throughout, the island of madagascar. the barks of these species are commonly used in traditional medicines for treating a wide range of maladies. the therapeutic nature of the bark is thought to be associated with its enrichment of pungent drimane sesquiterpenes, which elicit ant ... | 2018 | 29425195 |
| optimal control approach for establishing wmelpop wolbachia infection among wild aedes aegypti populations. | wolbachia-based biocontrol has recently emerged as a potential method for prevention and control of dengue and other vector-borne diseases. major vector species, such as aedes aegypti females, when deliberately infected with wolbachia become less capable of getting viral infections and transmitting the virus to human hosts. in this paper, we propose an explicit sex-structured population model that describes an interaction of uninfected (wild) male and female mosquitoes and those deliberately inf ... | 2018 | 29429122 |
| carica papaya (papaya) latex: a new paradigm to combat against dengue and filariasis vectors aedes aegypti and culex quinquefasciatus (diptera: culicidae). | this study manifests the larvicidal efficacy of carica papaya latex extract and silver nanoparticles (cpagnps) synthesized using latex, against developing immature juveniles of aedes aegypti and culex quinquefasciatus. briefly, the latex was collected and fractioned with different solvents such as chloroform, methanol and aqueously. the obtained crude extracts were subjected to larvicidal activity in the dose-dependent method. after 24 h, the mortality rate was calculated and statistically analy ... | 2018 | 29430347 |
| history dependence in insect flight decisions during odor tracking. | natural decision-making often involves extended decision sequences in response to variable stimuli with complex structure. as an example, many animals follow odor plumes to locate food sources or mates, but turbulence breaks up the advected odor signal into intermittent filaments and puffs. this scenario provides an opportunity to ask how animals use sparse, instantaneous, and stochastic signal encounters to generate goal-oriented behavioral sequences. here we examined the trajectories of flying ... | 2018 | 29432454 |
| the impact of insecticide applications on the dynamics of resistance: the case of four aedes aegypti populations from different brazilian regions. | in the tropics, the utilization of insecticides is still an important strategy for controlling aedes aegypti, the principle vector of dengue, chikungunya and zika viruses. however, increasing insecticide resistance in ae. aegypti populations might hinder insecticide efficacy on a long-term basis. it will be important to understand the dynamics and evolution of insecticide resistance by assessing its frequency and the mechanisms by which it occurs. | 2018 | 29432488 |
| functional characterization and quantitative expression analysis of two gnrh-related peptide receptors in the mosquito, aedes aegypti. | to cope with stressful events such as flight, organisms have evolved various regulatory mechanisms, often involving control by endocrine-derived factors. in insects, two stress-related factors include the gonadotropin-releasing hormone-related peptides adipokinetic hormone (akh) and corazonin (crz). akh is a pleiotropic hormone best known as a substrate liberator of proteins, lipids, and carbohydrates. although a universal function has not yet been elucidated, crz has been shown to have roles in ... | 2018 | 29432729 |
| modeling the spread of the zika virus using topological data analysis. | zika virus (zikv), a disease spread primarily through the aedes aegypti mosquito, was identified in brazil in 2015 and was declared a global health emergency by the world health organization (who). epidemiologists often use common state-level attributes such as population density and temperature to determine the spread of disease. by applying techniques from topological data analysis, we believe that epidemiologists will be able to better predict how zikv will spread. we use the vietoris-rips fi ... | 2018 | 29438377 |
| analysis of peptide ligand specificity of different insect adipokinetic hormone receptors. | adipokinetic hormone (akh) is a highly researched insect neuropeptide that induces the mobilization of carbohydrates and lipids from the fat body at times of high physical activity, such as flight and locomotion. as a naturally occurring ligand, akh has undergone quite a number of amino acid changes throughout evolution, and in some insect species multiple akhs are present. akh acts by binding to a rhodopsin-like g protein-coupled receptor, which is related to the vertebrate gonadotropin-releasi ... | 2018 | 29439466 |
| a point mutation v419l in the sodium channel gene from natural populations of aedes aegypti is involved in resistance to λ-cyhalothrin in colombia. | resistance to pyrethroids in mosquitoes is mainly caused by target site insensitivity known as knockdown resistance (kdr). in this work, we examined the point mutations present in portions of domains i, ii, iii, and iv of the sodium channel gene in aedes aegypti mosquitoes from three colombian municipalities. a partial region coding for the sodium channel gene from resistant mosquitoes was sequenced, and a simple allele-specific pcr-based assay (as-pcr) was used to analyze mutations at the popul ... | 2018 | 29443870 |
| mosquitoes of northwestern uganda. | despite evidence of arbovirus activity in northwestern uganda (west nile sub-region), there is very limited information on the mosquito fauna of this region. the only published study reported 52 mosquito species in northwestern uganda but this study took place in 1950 and the information has not been updated for more than 60 yr. in january and june 2011, co2 baited-light traps were used to collect 49,231 mosquitoes from four different locations, paraa (9,487), chobe (20,025), sunguru (759), and ... | 2018 | 29444287 |
| current and future distribution of aedes aegypti and aedes albopictus (diptera: culicidae) in who eastern mediterranean region. | aedes-borne diseases as dengue, zika, chikungunya and yellow fever are an emerging problem worldwide, being transmitted by aedes aegypti and aedes albopictus. lack of up to date information about the distribution of aedes species hampers surveillance and control. global databases have been compiled but these did not capture data in the who eastern mediterranean region (emr), and any models built using these datasets fail to identify highly suitable areas where one or both species may occur. the ... | 2018 | 29444675 |
| dynamic remodeling of lipids coincides with dengue virus replication in the midgut of aedes aegypti mosquitoes. | we describe the first comprehensive analysis of the midgut metabolome of aedes aegypti, the primary mosquito vector for arboviruses such as dengue, zika, chikungunya and yellow fever viruses. transmission of these viruses depends on their ability to infect, replicate and disseminate from several tissues in the mosquito vector. the metabolic environments within these tissues play crucial roles in these processes. since these viruses are enveloped, viral replication, assembly and release occur on ... | 2018 | 29447265 |
| analysis of cluster-randomized test-negative designs: cluster-level methods. | intervention trials of vector control methods often require community level randomization with appropriate inferential methods. for many interventions, the possibility of confounding due to the effects of health-care seeking behavior on disease ascertainment remains a concern. the test-negative design, a variant of the case-control method, was introduced to mitigate this issue in the assessment of the efficacy of influenza vaccination (measured at an individual level) on influenza infection. her ... | 2019 | 29447357 |
| entomological and epidemiological aspects of dengue epidemics in fortaleza, ceará, brazil, 2001-2012. | to characterize the entomological and epidemiological aspects of dengue epidemics occurred in fortaleza, ceará, brazil, from 2001 to 2012. | 2018 | 29451615 |
| environmental factors can influence dengue reported cases. | global climate changes directly affect the natural environment and contribute to an increase in the transmission of diseases by vectors. among these diseases, dengue is at the top of the list. the aim of our study was to understand the consequences of temporal variability of air temperature in the occurrence of dengue in an area comprising seven municipalities of the greater são paulo. | 2017 | 29451659 |
| synergistic effect of entomopathogenic fungus fusarium oxysporum extract in combination with temephos against three major mosquito vectors. | mosquito control using chemical insecticides is facing a major challenge due to development of insecticide resistance. improving the efficiency of existing insecticides using synergistic secondary metabolites of biological origin is increasingly being researched. herein, we evaluated the toxicity of fusarium oxysporum extract alone and in binary combinations with temephos, on larvae and pupae of anopheles stephensi, aedes aegypti and culex quinquefaciatus. f. oxysporum extract was characterized ... | 2018 | 29457957 |
| larvicidal activity of selected plant extracts and their combination against the mosquito vectors culex quinquefasciatus and aedes aegypti. | in order to develop an environment-friendly botanical mosquito larvicide alternative to the chemical larvicides, extracts were made from the leaves of hyptis suaveolens, lantana camara, nerium oleander, and tecoma stans with three organic solvents such as methanol (me), chloroform (ch), and petroleum ether (pe) using a soxhlet extractor. the plant extracts were screened for larvicidal activity individually and in combination against the larvae of aedes aegypti and culex quinquefasciatus as per w ... | 2018 | 29460245 |
| improving vector-borne pathogen surveillance: a laboratory-based study exploring the potential to detect dengue virus and malaria parasites in mosquito saliva. | vector-borne pathogen surveillance programmes typically rely on the collection of large numbers of potential vectors followed by screening protocols focused on detecting pathogens in the arthropods. these processes are laborious, time consuming, expensive, and require screening of large numbers of samples. to streamline the surveillance process, increase sample throughput, and improve cost-effectiveness, a method to detect dengue virus and malaria parasites (plasmodium falciparum) by leveraging ... | 2018 | 29460859 |
| host plant forensics and olfactory-based detection in afro-tropical mosquito disease vectors. | the global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival and other metabolic processes. however, the identity of plant species mosquitoes feed on in nature remains largely unknown. by testing the hypothesis about selectivity in plant feed ... | 2018 | 29462150 |
| seasonal distribution and container preference ratio of the dengue fever vector (aedes aegypti, diptera: culicidae) in rawalpindi, pakistan. | aedes aegypti (l.) and aedes albopictus (skuse) are known vectors of dengue, chikungunya, and other pathogens; however, their ecology and role in virus transmission has not been well studied in pakistan. here, we report on an intensive survey of potential breeding sites of ae. aegypti in rawalpindi, punjab province, pakistan. the study continued for 11 mo and was divided into three seasons: january to june (pre-monsoon), july to september (monsoon), and october-november (post-monsoon). larval mo ... | 2018 | 29462424 |
| using adult aedes aegypti females to predict areas at risk for dengue transmission: a spatial case-control study. | traditional indices for measuring dengue fever risk in a given area are based on the immature forms of the vector (larvae and pupae surveys). however, this is inefficient because only adult female mosquitoes actually transmit the virus. based on these assumptions, our objective was to evaluate the association between an entomological index obtained from adult mosquito traps and the occurrence of dengue in a hyperendemic area. additionally, we compared its cost to that of the breteau index (bi). | 2018 | 29462598 |
| effectiveness of a field trap barrier system for controlling aedes albopictus: a "removal trapping" strategy. | aedes aegypti and aedes albopictus are the main vectors for the transmission of several viral pathogens, in particular, dengue, zika and chikungunya. in the absence of vaccines and treatment, control of aedes mosquitoes is the only means of keeping these diseases in check. aedes control is difficult, and it is, therefore, necessary to evaluate the efficacy of novel control methods, particularly those targeting adult and exophilic ae. albopictus populations. | 2018 | 29463300 |
| alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on aedes aegypti larvae. | aedes aegypti mosquitoes are responsible for dengue, chikungunya, and zika virus transmission in tropical and subtropical areas around the world. due to the absence of vaccines or antiviral drugs for human treatment, the majority of control strategies are targeted at ae. aegypti elimination. our research on mosquito control insecticidal agents has previously shown that the alkaloid girgensohnine and its analogues (α-aminonitriles) present in vitro acetylcholinesterase inhibition and in vivo inse ... | 2018 | 29463410 |