Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| socioeconomic and ecological factors influencing aedes aegypti prevalence, abundance, and distribution in dhaka, bangladesh. | this study examined household risk factors and prevalence, abundance, and distribution of immature aedes aegypti and aedes albopictus, and their association with socioeconomic and ecological factors at urban zonal and household levels in the city of dhaka, bangladesh. during the 2011 monsoon, 826 households in 12 randomly selected administrative wards were surveyed for vector mosquitoes. results revealed that the abundance and distribution of immature ae. aegypti and ae. albopictus, and pupae-pe ... | 2016 | 27022149 |
| control of urban zika vectors: should we return to the successful paho/who strategy? | 2016 | 27249063 | |
| the mouthparts enriched odorant binding protein 11 of the alfalfa plant bug adelphocoris lineolatus displays a preferential binding behavior to host plant secondary metabolites. | odorant binding proteins (obps) are proposed to be directly required for odorant discrimination and represent potential interesting targets for pest control. in the notoriously agricultural pest adelphocoris lineolatus, our previous functional investigation of highly expressed antennal obps clearly supported this viewpoint, whereas the findings of the current study by characterizing of alinobp11 rather indicated that obp in hemipterous plant bugs might fulfill a different and tantalizing physiol ... | 2016 | 27313540 |
| another pandemic disaster looms: yellow fever spreading from angola. | 2016 | 27642446 | |
| combinatorial gene regulatory functions underlie ultraconserved elements in drosophila. | ultraconserved elements (uces) are discrete genomic elements conserved across large evolutionary distances. although uces have been linked to multiple facets of mammalian gene regulation their extreme evolutionary conservation remains largely unexplained. here, we apply a computational approach to investigate this question in drosophila, exploring the molecular functions of more than 1,500 uces shared across the genomes of 12 drosophila species. our data indicate that drosophila uces are hubs fo ... | 2016 | 27247329 |
| antifilarial activity of diterpenoids from taxodium distichum. | lymphatic filariasis caused by wuchereria bancrofti, brugia malayi and b. timori, is a debilitating disease with an adverse social and economic impact. the infection remains unabated in spite of treatment with existing antifilarial drugs diethylcarbamazine (dec) and ivermectin which are chiefly microfilaricides. there is therefore, need for macrofilaricides, embryostatic agents and better microfilaricides. in the present study we explored the antifilarial potential of crude extract and its molec ... | 2016 | 27245322 |
| outwitting dengue threat and epidemics resurgence in asia-pacific countries: strengthening integrated dengue surveillance, monitoring and response systems. | dengue is still a substantial vector-borne viral disease threat and burden of public health importance worldwide. this situation is complicated by dengue virus unprecedented resurgence and persistence of varied serotypes in endemic-prone areas, and man-made and natural activities consequences that promote vector emergence, transmission dynamics and spread across the asia-pacific region. there is an urgent need to strengthen operational and contextual surveillance-response research in improving e ... | 2016 | 27233238 |
| correction: spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. | [this corrects the article doi: 10.1371/journal.pntd.0004664.]. | 2016 | 27232603 |
| different effects of metarhizium anisopliae strains imi330189 and ibc200614 on enzymes activities and hemocytes of locusta migratoria l. | metarhizium is an important class of entomopathogenic fungi in the biocontrol of insects, but its virulence is affected by insect immunity. to clarify the mechanism in virulence of metarhizium, we compared the immunological differences in locusta migratoria l. when exposed to two strains of metarhizium anisopliae (ma). | 2016 | 27227835 |
| experimental infection of rhodnius prolixus (hemiptera, triatominae) with mycobacterium leprae indicates potential for leprosy transmission. | leprosy is a chronic dermato-neurological disease caused by infection with mycobacterium leprae. in 2013 almost 200,000 new cases of leprosy were detected around the world. since the first symptoms take from years to decades to appear, the total number of asymptomatic patients is impossible to predict. although leprosy is one of the oldest records of human disease, the mechanisms involved with its transmission and epidemiology are still not completely understood. in the present work, we experime ... | 2016 | 27203082 |
| exposure to aedes aegypti bites induces a mixed-type allergic response following salivary antigens challenge in mice. | classical studies have shown that aedes aegypti salivary secretion is responsible for the sensitization to mosquito bites and many of the components present in saliva are immunogenic and capable of inducing an intense immune response. therefore, we have characterized a murine model of adjuvant-free systemic allergy induced by natural exposure to mosquito bites. balb/c mice were sensitized by exposure to a. aegypti mosquito bites and intranasally challenged with phosphate-buffered saline only or ... | 2016 | 27203689 |
| molecular characterization and function analysis of the vitellogenin receptor from the cotton bollworm, helicoverpa armigera (hübner) (lepidoptera, noctuidae). | developing oocytes accumulate plentiful yolk protein during oogenesis through receptor-mediated endocytosis. the vitellogenin receptor (vgr), belonging to the low-density lipoprotein receptor (ldlr) family, regulates the absorption of yolk protein. in this work, the full-length vitellogenin receptor (havgr) in the cotton bollworm helicoverpa armigera was identified, encoding a 1817 residue protein. sequence alignment revealed that the sequence of havgr contained all of the conservative structura ... | 2016 | 27192057 |
| mammalian african trypanosome vsg coat enhances tsetse's vector competence. | tsetse flies are biological vectors of african trypanosomes, the protozoan parasites responsible for causing human and animal trypanosomiases across sub-saharan africa. currently, no vaccines are available for disease prevention due to antigenic variation of the variant surface glycoproteins (vsg) that coat parasites while they reside within mammalian hosts. as a result, interference with parasite development in the tsetse vector is being explored to reduce disease transmission. a major bottlene ... | 2016 | 27185908 |
| a critical role for the drosophila dopamine d1-like receptor dop1r2 at the onset of metamorphosis. | insect metamorphosis relies on temporal and spatial cues that are precisely controlled. previous studies in drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. multiple factors exist that safeguard these genes against dysregulated expression. the list of identified negative regulators that play such a role in drosophila development continues to expand. | 2016 | 27184815 |
| an rna-dependent rna polymerase gene in bat genomes derived from an ancient negative-strand rna virus. | endogenous bornavirus-like l (ebll) elements are inheritable sequences derived from ancient bornavirus l genes that encode a viral rna-dependent rna polymerase (rdrp) in many eukaryotic genomes. here, we demonstrate that bats of the genus eptesicus have preserved for more than 11.8 million years an ebll element named eebll-1, which has an intact open reading frame of 1,718 codons. the eebll-1 coding sequence revealed that functional motifs essential for mononegaviral rdrp activity are well conse ... | 2016 | 27174689 |
| de novo transcriptome analysis and detection of antimicrobial peptides of the american cockroach periplaneta americana (linnaeus). | cockroaches are surrogate hosts for microbes that cause many human diseases. in spite of their generally destructive nature, cockroaches have recently been found to harbor potentially beneficial and medically useful substances such as drugs and allergens. however, genomic information for the american cockroach (periplaneta americana) is currently unavailable; therefore, transcriptome and gene expression profiling is needed as an important resource to better understand the fundamental biological ... | 2016 | 27167617 |
| comprehensive evaluation of candidate reference genes for qrt-pcr studies of gene expression in mustard aphid, lipaphis erysimi (kalt). | mustard aphid, also known as turnip aphid (lipaphis erysimi) is a major insect pest of rapeseed-mustard group of crops. tremendous economic significance has led to substantial basic research involving gene-expression studies in this insect species. in qrt-pcr analysis of gene-expression, normalization of data against rna variation by using appropriate reference gene is fundamental. however, appropriate reference genes are not known in case of l. erysimi. we evaluated 11 candidate reference genes ... | 2016 | 27165720 |
| myosin myth4-ferm structures highlight important principles of convergent evolution. | myosins containing myth4-ferm (myosin tail homology 4-band 4.1, ezrin, radixin, moesin, or mf) domains in their tails are found in a wide range of phylogenetically divergent organisms, such as humans and the social amoeba dictyostelium (dd). interestingly, evolutionarily distant mf myosins have similar roles in the extension of actin-filled membrane protrusions such as filopodia and bind to microtubules (mt), suggesting that the core functions of these mf myosins have been highly conserved over ... | 2016 | 27166421 |
| midgut transcriptome of the cockroach periplaneta americana and its microbiota: digestion, detoxification and oxidative stress response. | the cockroach, periplaneta americana, is an obnoxious and notorious pest of the world, with a strong ability to adapt to a variety of complex environments. however, the molecular mechanism of this adaptability is mostly unknown. in this study, the genes and microbiota composition associated with the adaptation mechanism were studied by analyzing the transcriptome and 16s rdna pyrosequencing of the p. americana midgut, respectively. midgut transcriptome analysis identified 82,905 unigenes, among ... | 2016 | 27153200 |
| hawkmoths evaluate scenting flowers with the tip of their proboscis. | pollination by insects is essential to many ecosystems. previously, we have shown that floral scent is important to mediate pollen transfer between plants (kessler et al., 2015). yet, the mechanisms by which pollinators evaluate volatiles of single flowers remained unclear. here, nicotiana attenuata plants, in which floral volatiles have been genetically silenced and its hawkmoth pollinator, manduca sexta, were used in semi-natural tent and wind-tunnel assays to explore the function of floral sc ... | 2016 | 27146894 |
| evolution, expression, and function of nonneuronal ligand-gated chloride channels in drosophila melanogaster. | ligand-gated chloride channels have established roles in inhibitory neurotransmission in the nervous systems of vertebrates and invertebrates. paradoxically, expression databases in drosophila melanogaster have revealed that three uncharacterized ligand-gated chloride channel subunits, cg7589, cg6927, and cg11340, are highly expressed in nonneuronal tissues. furthermore, subunit copy number varies between insects, with some orders containing one ortholog, whereas other lineages exhibit copy numb ... | 2016 | 27172217 |
| ionotropic chemosensory receptors mediate the taste and smell of polyamines. | the ability to find and consume nutrient-rich diets for successful reproduction and survival is fundamental to animal life. among the nutrients important for all animals are polyamines, a class of pungent smelling compounds required in numerous cellular and organismic processes. polyamine deficiency or excess has detrimental effects on health, cognitive function, reproduction, and lifespan. here, we show that a diet high in polyamine is beneficial and increases reproductive success of flies, and ... | 2016 | 27145030 |
| imbalanced hemolymph lipid levels affect feeding motivation in the two-spotted cricket, gryllus bimaculatus. | insect feeding behavior is regulated by many intrinsic factors, including hemolymph nutrient levels. adipokinetic hormone (akh) is a peptide factor that modulates hemolymph nutrient levels and regulates the nutritional state of insects by triggering the transfer of lipids into the hemolymph. we recently demonstrated that rna interference (rnai)-mediated knockdown of the akh receptor (akhr) reduces hemolymph lipid levels, causing an increase in the feeding frequency of the two-spotted cricket, gr ... | 2016 | 27144650 |
| sequence conservation and sexually dimorphic expression of the ftz-f1 gene in the crustacean daphnia magna. | identifying the genes required for environmental sex determination is important for understanding the evolution of diverse sex determination mechanisms in animals. orthologs of drosophila orphan receptor fushi tarazu factor-1 (ftz-f1) are known to function in genetic sex determination. in contrast, their roles in environmental sex determination remain unknown. in this study, we have cloned and characterized the ftz-f1 ortholog in the branchiopod crustacean daphnia magna, which produces males in ... | 2016 | 27138373 |
| differential gene expression analysis of the epacromius coerulipes (orthoptera: acrididae) transcriptome. | epacromius coerulipes (ivanov) is one of the most widely distributed locusts. to date, the main methods to kill locusts still rely on chemical controls, which can result in the selection of locusts with resistance to chemical pesticides. butene-fipronil is a new pesticide that was discovered by the structural modification of fipronil. this pesticide has been used to control various agricultural pests and has become an important pesticide product to control pests that exhibit resistance to other ... | 2016 | 27142308 |
| serological and entomological study of dengue in dang and chitwan districts of nepal. | a descriptive cross-sectional study was carried out among 264 suspected dengue patients in two districts (dang and chitwan) of nepal from june 2013 to november 2013. the anti-dengue igm positivity was found to be (51/264)19.31% by capture elisa, of which 21 (41.2%) were male and 30 (58.8%) were female. symptoms of seropositive cases were fever, anorexia, nausea, headache, retro-orbital pain, skin rashes, and myalgia. hematological features like thrombocytopenia and leucopenia were found to be si ... | 2016 | 26828951 |
| afrocolombian ethnicity, a paradoxical protective factor against dengue. | dengue is a priority public health problem. during epidemics in cuba and haiti, ethnic african descendant population had lower risk of dengue, and the ethnic factor was proposed as a protective one. | 2016 | 27821892 |
| transcript abundance of photorhabdus insect-related (pir) toxin in manduca sexta and galleria mellonella infections. | in this study, we assessed pirab toxin transcription in photorhabdus luminescens laumondii (strain tt01) (enterobacteriaceae) by comparing mrna abundance under in vivo and in vitro conditions. in vivo assays considered both natural and forced infections with two lepidopteran hosts: galleria mellonella and manduca sexta. three portals of entry were utilized for the forced infection assays: (a) integument; (b) the digestive route (via mouth and anus); and (c) the tracheal route (via spiracles). we ... | 2016 | 27690103 |
| developmental pirna profiles of the invasive vector mosquito aedes albopictus. | in eukaryotic organisms, piwi-interacting rnas (pirnas) control the activities of mobile genetic elements and ensure genome maintenance. recent evidence indicates that pirnas are involved in multiple biological pathways, including transcriptional regulation of protein-coding genes, sex determination and even interactions between host and pathogens. aedes albopictus is a major invasive species that transmits a number of viral diseases in humans. ae. albopictus has the largest genome and the highe ... | 2016 | 27686069 |
| kap surveys and dengue control in colombia: disentangling the effect of sociodemographic factors using multiple correspondence analysis. | during the last few decades, several studies have analyzed and described knowledge, attitudes, and practices (kap) of populations regarding dengue. however, few studies have applied geometric data analytic techniques to generate indices from kap domains. results of such analyses have not been used to determine the potential effects of sociodemographic variables on the levels of kap. the objective was to determine the sociodemographic factors related to different levels of kap regarding dengue in ... | 2016 | 27682141 |
| spatial variations in dengue transmission in schools in thailand. | dengue is an important neglected tropical disease, with more than half of the world's population living in dengue endemic areas. good understanding of dengue transmission sites is a critical factor to implement effective vector control measures. | 2016 | 27669170 |
| n6-(2-hydroxyethyl)-adenosine exhibits insecticidal activity against plutella xylostella via adenosine receptors. | the diamondback moth, plutella xylostella, is one of the most important pests of cruciferous crops. we have earlier shown that n6-(2-hydroxyethyl)-adenosine (hea) exhibits insecticidal activity against p. xylostella. in the present study we investigated the possible mechanism of insecticidal action of hea on p. xylostella. hea is a derivative of adenosine, therefore, we speculated whether it acts via p. xylostella adenosine receptor (pxador). we used rnai approach to silence pxador gene and used ... | 2016 | 27668428 |
| evaluating the performance of infectious disease forecasts: a comparison of climate-driven and seasonal dengue forecasts for mexico. | dengue viruses, which infect millions of people per year worldwide, cause large epidemics that strain healthcare systems. despite diverse efforts to develop forecasting tools including autoregressive time series, climate-driven statistical, and mechanistic biological models, little work has been done to understand the contribution of different components to improved prediction. we developed a framework to assess and compare dengue forecasts produced from different types of models and evaluated t ... | 2016 | 27665707 |
| predicted structure of a minus-c obp from batocera horsfieldi (hope) suggests an intermediate structure in evolution of obps. | odorant binding proteins (obps) transport hydrophobic odorants from the environment to odorant receptors and play an important role in specific recognition of volatiles. here, we expressed and purified a minus-c obp, bhorobpm2, from batocera horsfieldi, a major pest of popolus, to determine its binding characteristics with 58 candidate volatiles using a fluorescence competition-binding assay. we showed that bhorobpm2 exhibited high binding affinity with chain volatiles and that ligands were sele ... | 2016 | 27659921 |
| potential of camellia sinensis proanthocyanidins-rich fraction for controlling malaria mosquito populations through disruption of larval development. | anopheles arabiensis and a. gambiae (sensu stricto) are the most prolific afrotropical malaria vectors. population control efforts of these two vectors have been hampered by extremely diverse larval breeding sites and widespread resistance to currently available insecticides. control of mosquito larval stages using bioactive compounds of plant origin has the potential to suppress vector populations leading to concomitant reduction in disease transmission rates. in this study, we evaluated the ef ... | 2016 | 27660043 |
| the whole genome sequence of the mediterranean fruit fly, ceratitis capitata (wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species. | the mediterranean fruit fly (medfly), ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. it exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (sit) as part of integrated pest management programs (ipms). the genetic analysis and manipulation of medf ... | 2016 | 27659211 |
| sit 2.0: 21(st) century genetic technology for the screwworm sterile-insect program. | release of sterile insects, the sterile insect technique (sit), can be an extremely effective and precise method of pest control. a study in bmc biology from the new world screwworm sit program and others shows that modern genetic methods can provide major improvements even to this well-established and highly successful sit program.see research article: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0296-8. | 2016 | 27643991 |
| gc content heterogeneity transition of conserved noncoding sequences occurred at the emergence of vertebrates. | conserved non-coding sequences (cnss) of eukaryotes are known to be significantly enriched in regulatory sequences. cnss of diverse lineages follow different patterns in abundance, sequence composition, and location. here, we report a thorough analysis of cnss in diverse groups of eukaryotes with respect to gc content heterogeneity. we examined 24 fungi, 19 invertebrates, and 12 non-mammalian vertebrates so as to find lineage specific features of cnss. we found that fungi and invertebrate cnss a ... | 2016 | 28040773 |
| non-mendelian dominant maternal effects caused by crispr/cas9 transgenic components in drosophila melanogaster. | the crispr/cas9 system has revolutionized genomic editing. the cas9 endonuclease targets genomic dna via an experimentally determined guide rna (grna). this results in a double-strand break at the target site. we generated transgenic drosophila melanogaster in which the crispr/cas9 system was used to target a gal4 transgene in vivo to our surprise, progeny whose genomes did not contain crispr/cas9 components were still capable of mutating gal4 sequences. we demonstrate this effect was caused by ... | 2016 | 27638686 |
| smshb, the sh2-containing adaptor protein b of schistosoma mansoni regulates venus kinase receptor signaling pathways. | venus kinase receptors (vkrs) are invertebrate receptor tyrosine kinases (rtks) formed by an extracellular venus fly trap (vft) ligand binding domain associated via a transmembrane domain with an intracellular tyrosine kinase (tk) domain. schistosoma mansoni vkrs, smvkr1 and smvkr2, are both implicated in reproductive activities of the parasite. in this work, we show that the sh2 domain-containing protein smshb is a partner of the phosphorylated form of smvkr1. expression of these proteins in xe ... | 2016 | 27636711 |
| lbd1 of vitellogenin receptor specifically binds to the female-specific storage protein sp1 via lbr1 and lbr3. | storage proteins are the major protein synthesized in the fat body, released into hemolymph and re-sequestered into the fat body before pupation in most insect species. storage proteins are important amino acid and nutrition resources during the non-feeding pupal period and play essential roles for the metamorphosis and oogenesis of insects. the sequestration of storage protein is a selective, specific receptor-mediated process. however, to date, the potential receptor mediating the sequestratio ... | 2016 | 27637099 |
| maintenance of host dna integrity in field-preserved mosquito (diptera: culicidae) blood meals for identification by dna barcoding. | determination of the interactions between hematophagous arthropods and their hosts is a necessary component to understanding the transmission dynamics of arthropod-vectored pathogens. current molecular methods to identify hosts of blood-fed arthropods require the preservation of host dna to serve as an amplification template. during transportation to the laboratory and storage prior to molecular analysis, genetic samples need to be protected from nucleases, and the degradation effects of hydroly ... | 2016 | 27629021 |
| agricultural chemicals: life changer for mosquito vectors in agricultural landscapes? | although many mosquito species develop within agricultural landscapes where they are potentially exposed to agricultural chemicals (fertilizers and pesticides), the effects of these chemicals on mosquito biology remain poorly understood. this study investigated the effects of sublethal concentrations of four agricultural chemicals on the life history traits of anopheles arabiensis and culex quinquefasciatus mosquitoes. | 2016 | 27624456 |
| silencing the olfactory co-receptor rferorco reduces the response to pheromones in the red palm weevil, rhynchophorus ferrugineus. | the red palm weevil (rpw, rhynchophorus ferrugineus), one of the most widespread of all invasive insect pest species, is a major cause of severe damage to economically important palm trees. rpw exhibits behaviors very similar to those of its sympatric species, the asian palm weevil (r. vulneratus), which is restricted geographically to the southern part of southeast asia. although efficient and sustainable control of these pests remains challenging, olfactory-system disruption has been proposed ... | 2016 | 27606688 |
| evolutionary dynamics of abundant stop codon readthrough. | translational stop codon readthrough emerged as a major regulatory mechanism affecting hundreds of genes in animal genomes, based on recent comparative genomics and ribosomal profiling evidence, but its evolutionary properties remain unknown. here, we leverage comparative genomic evidence across 21 anopheles mosquitoes to systematically annotate readthrough genes in the malaria vector anopheles gambiae, and to provide the first study of abundant readthrough evolution, by comparison with 20 droso ... | 2016 | 27604222 |
| the tomato spotted wilt virus genome is processed differentially in its plant host arachis hypogaea and its thrips vector frankliniella fusca. | thrips-transmitted tospoviruses are economically important viruses affecting a wide range of field and horticultural crops worldwide. tomato spotted wilt virus (tswv) is the type member of the tospovirus genus with a broad host range of more than 900 plant species. interactions between these viruses and their plant hosts and insect vectors via rnai pathways are likely a key determinant of pathogenicity. the current investigation, for the first time, compares biogenesis of small rnas between the ... | 2016 | 27656190 |
| rhodopsin 7-the unusual rhodopsin in drosophila. | rhodopsins are the major photopigments in the fruit fly drosophila melanogaster. drosophila express six well-characterized rhodopsins (rh1-rh6) with distinct absorption maxima and expression pattern. in 2000, when the drosophila genome was published, a novel rhodopsin gene was discovered: rhodopsin 7 (rh7). rh7 is highly conserved among the drosophila genus and is also found in other arthropods. phylogenetic trees based on protein sequences suggest that the seven drosophila rhodopsins cluster in ... | 2016 | 27651995 |
| spatiotemporal analysis of dengue fever in nepal from 2010 to 2014. | due to recent emergence, dengue is becoming one of the major public health problems in nepal. the numbers of reported dengue cases in general and the area with reported dengue cases are both continuously increasing in recent years. however, spatiotemporal patterns and clusters of dengue have not been investigated yet. this study aims to fill this gap by analyzing spatiotemporal patterns based on monthly surveillance data aggregated at district. | 2016 | 27549095 |
| the silencing of a 14-3-3ɛ homolog in tenebrio molitor leads to increased antimicrobial activity in hemocyte and reduces larval survivability. | the 14-3-3 family of phosphorylated serine-binding proteins acts as signaling molecules in biological processes such as metabolism, division, differentiation, autophagy, and apoptosis. herein, we report the requirement of 14-3-3ɛ isoform from tenebrio molitor (tm14-3-3ɛ) in the hemocyte antimicrobial activity. the tm14-3-3ɛ transcript is 771 nucleotides in length and encodes a polypeptide of 256 amino acid residues. the protein has the typical 14-3-3 domain, the nuclear export signal (nes) seque ... | 2016 | 27556493 |
| rural-urban comparisons of dengue seroprevalence in malaysia. | each year an estimated 390 million dengue infections occur worldwide. in malaysia, dengue is a growing public health concern but estimate of its disease burden remains uncertain. we compared the urban-rural difference of dengue seroprevalence and determined age-specific dengue seroprevalence in malaysia. | 2016 | 27538986 |
| genome-wide profiling of 24 hr diel rhythmicity in the water flea, daphnia pulex: network analysis reveals rhythmic gene expression and enhances functional gene annotation. | marine and freshwater zooplankton exhibit daily rhythmic patterns of behavior and physiology which may be regulated directly by the light:dark (ld) cycle and/or a molecular circadian clock. one of the best-studied zooplankton taxa, the freshwater crustacean daphnia, has a 24 h diel vertical migration (dvm) behavior whereby the organism travels up and down through the water column daily. dvm plays a critical role in resource tracking and the behavioral avoidance of predators and damaging ultravio ... | 2016 | 27538446 |
| the buzz about honey bee viruses. | 2016 | 27537076 | |
| symptomatic dengue disease in five southeast asian countries: epidemiological evidence from a dengue vaccine trial. | dengue incidence has increased globally, but empirical burden estimates are scarce. prospective methods are best-able to capture all severities of disease. cyd14 was an observer-blinded dengue vaccine study conducted in children 2-14 years of age in indonesia, malaysia, thailand, the philippines, and vietnam. the control group received no vaccine and resembled a prospective, observational study. we calculated the rates of dengue according to different laboratory or clinical criteria to make infe ... | 2016 | 27532617 |
| multiple modes of action of the squamocin in the midgut cells of aedes aegypti larvae. | annonaceous acetogenins are botanical compounds with good potential for use as insecticides. in the vector, aedes aegypti (l.) (diptera: culicidae), squamocin (acetogenin) has been reported to be a larvicide and cytotoxic, but the modes of action of this molecule are still poorly understood. this study evaluated the changes in the cell morphology, and in the expression of genes, for autophagy (atg1 and atg8), for membrane ion transporter v-atpase, and for water channel aquaporin-4 (aqp4) in the ... | 2016 | 27532504 |
| nationwide study of factors associated with public's willingness to use home self-test kit for dengue fever in malaysia. | as there is no specific treatment for dengue, early detection and access to proper treatment may lower dengue fatality. therefore, having new techniques for the early detection of dengue fever, such as the use of dengue test kit, is vitally important. the aims of the study were: 1) identify factors associated with acceptance of a home self-test kit for dengue fever if the dengue test is available to the public and 2) find out the characteristics of the test kits that influence the use of the den ... | 2016 | 27520825 |
| traditional medicine practices among community members with diabetes mellitus in northern tanzania: an ethnomedical survey. | diabetes is a growing burden in sub-saharan africa where traditional medicines (tms) remain a primary form of healthcare in many settings. in tanzania, tms are frequently used to treat non-communicable diseases, yet little is known about tm practices for non-communicable diseases like diabetes. | 2016 | 27514380 |
| calculation of the average cost per case of dengue fever in mexico using a micro-costing approach. | the increasing burden of dengue fever (df) in the americas, and the current epidemic in previously unaffected countries, generate major costs for national healthcare systems. there is a need to quantify the average cost per df case. in mexico, few data are available on costs, despite df being endemic in some areas. extrapolations from studies in other countries may prove unreliable and are complicated by the two main mexican healthcare systems (the secretariat of health [ss] and the mexican soci ... | 2016 | 27501146 |
| surveillance, insecticide resistance and control of an invasive aedes aegypti (diptera: culicidae) population in california. | the invasion and subsequent establishment in california of aedes aegypti in 2013 has created new challenges for local mosquito abatement and vector control districts. studies were undertaken to identify effective and economical strategies to monitor the abundance and spread of this mosquito species as well as for its control. overall, bg sentinel (bgs) traps were found to be the most sensitive trap type to measure abundance and spread into new locations. autocidal-gravid-ovitraps (ago-b), when p ... | 2016 | 27158450 |
| dengue serotype immune-interactions and their consequences for vaccine impact predictions. | dengue is one of the most important and wide-spread viral infections affecting human populations. the last few decades have seen a dramatic increase in the global burden of dengue, with the virus now being endemic or near-endemic in over 100 countries world-wide. a recombinant tetravalent vaccine candidate (cyd-tdv) has recently completed phase iii clinical efficacy trials in south east asia and latin america and has been licensed for use in several countries. the trial results showed moderate-t ... | 2016 | 27663790 |
| virus-derived dna drives mosquito vector tolerance to arboviral infection. | mosquitoes develop long-lasting viral infections without substantial deleterious effects, despite high viral loads. this makes mosquitoes efficient vectors for emerging viral diseases with enormous burden on public health. how mosquitoes resist and/or tolerate these viruses is poorly understood. here we show that two species of aedes mosquitoes infected with two arboviruses from distinct families (dengue or chikungunya) generate a viral-derived dna (vdna) that is essential for mosquito survival ... | 2016 | 27580708 |
| transcriptional analysis of the adaptive digestive system of the migratory locust in response to plant defensive protease inhibitors. | herbivorous insects evolved adaptive mechanisms to compensate for the presence of plant defensive protease inhibitors (pi) in their food. the underlying regulatory mechanisms of these compensatory responses remain largely elusive. in the current study, we investigated the initiation of this adaptive response in the migratory locust, locusta migratoria, via microarray analysis of gut tissues. four hours after dietary uptake of pis, 114 and 150 transcripts were respectively found up- or downregula ... | 2016 | 27581362 |
| crygetter: a tool to automate retrieval and analysis of cry protein data. | for many years, the use of chemical agents to control crop pests has been degrading the environment, bringing problems to humans and all living things. an alternative to deal with the pests is the use of biopesticides, biological agents capable of controlling these harmful organisms. one kind of biopesticide is bacillus thuringiensis, a gram-positive bacterium that synthesizes a protein that, when ingested by the pests, kills them and does not harm other species. | 2016 | 27578522 |
| transcriptional differences between diapausing and non-diapausing d. montana females reared under the same photoperiod and temperature. | a wide range of insects living at higher latitudes enter diapause at the end of the warm season, which increases their chances of survival through harsh winter conditions. in this study we used rna sequencing to identify genes involved in adult reproductive diapause in a northern fly species, drosophila montana. both diapausing and non-diapausing flies were reared under a critical day length and temperature, where about half of the emerging females enter diapause enabling us to eliminate the eff ... | 2016 | 27571415 |
| the correlation between dengue incidence and diurnal ranges of temperature of colombo district, sri lanka 2005-2014. | meteorological factors affect dengue transmission. mechanisms of the way in which different diurnal temperatures, ranging around different mean temperatures, influence dengue transmission were published after 2011. | 2016 | 27566717 |
| developmental expression of ecdysone-related genes associated with metamorphic changes during midgut remodeling of silkworm bombyx mori (lepidoptera:bombycidae). | steroid hormone 20-hydroxyecdysone is known as the systemic regulators of insect cells; however, how to impact the fate and function of mature and stem cells is unclear. for the first time, we report ecdysone regulatory cascades in both mature midgut cell and stem cell fractions related to developmental events by using histological, immunohistochemical, biochemical and gene expression analysis methods. ecdysone receptor-b1 (ecr-b1) and ultraspiracle 1 (usp-1) mrnas were detected mainly in mature ... | 2016 | 27620558 |
| climate variation drives dengue dynamics. | dengue, a viral infection transmitted between people by mosquitoes, is one of the most rapidly spreading diseases in the world. here, we report the analyses covering 11 y (2005-2015) from the city of guangzhou in southern china. using the first 8 y of data to develop an ecologically based model for the dengue system, we reliably predict the following 3 y of dengue dynamics-years with exceptionally extensive dengue outbreaks. we demonstrate that climate conditions, through the effects of rainfall ... | 2016 | 27940911 |
| resistance to genetic insect control: modelling the effects of space. | genetic insect control, such as self-limiting ridl(2) (release of insects carrying a dominant lethal) technology, is a development of the sterile insect technique which is proposed to suppress wild populations of a number of major agricultural and public health insect pests. this is achieved by mass rearing and releasing male insects that are homozygous for a repressible dominant lethal genetic construct, which causes death in progeny when inherited. the released genetically engineered ('ge') in ... | 2016 | 27816677 |
| molecular virologic and clinical characteristics of a chikungunya fever outbreak in la romana, dominican republic, 2014. | since emerging in saint martin in 2013, chikungunya virus (chikv), an alphavirus transmitted by the aedes aegypti mosquito, has infected approximately two million individuals in the americas, with over 500,000 reported cases in the dominican republic (dr). chikv-infected patients typically present with a febrile syndrome including polyarthritis/polyarthralgia, and a macropapular rash, similar to those infected with dengue and zika viruses, and malaria. nevertheless, many dominican cases are unco ... | 2016 | 28030537 |
| imitedb: the genome-wide landscape of miniature inverted-repeat transposable elements in insects. | miniature inverted-repeat transposable elements (mites) have attracted much attention due to their widespread occurrence and high copy numbers in eukaryotic genomes. however, the systematic knowledge about mites in insects and other animals is still lacking. in this study, we identified 6012 mite families from 98 insect species genomes. comparison of these mites with known mites in the ncbi non-redundant database and repbase showed that 5701(∼95%) of 6012 mite families are novel. the abundance o ... | 2016 | 28025339 |
| an overview of trypanosoma brucei infections: an intense host-parasite interaction. | trypanosoma brucei rhodesiense and t. brucei gambiense, the causative agents of human african trypanosomiasis, are transmitted by tsetse flies. within the vector, the parasite undergoes through transformations that prepares it to infect the human host. sequentially these developmental stages are the replicative procyclic (in which the parasite surface is covered by procyclins) and trypo-epimastigote forms, as well as the non-replicative, infective, metacyclic form that develops in the vector sal ... | 2016 | 28082973 |
| functional evolution of a morphogenetic gradient. | bone morphogenetic proteins (bmps) pattern the dorsal-ventral axis of bilaterian embryos; however, their roles in the evolution of body plan are largely unknown. we examined their functional evolution in fly embryos. bmp signaling specifies two extraembryonic tissues, the serosa and amnion, in basal-branching flies such as megaselia abdita, but only one, the amnioserosa, in drosophila melanogaster. the bmp signaling dynamics are similar in both species until the beginning of gastrulation, when b ... | 2016 | 28005004 |
| control of vector-borne human parasitic diseases. | 2016 | 28090535 | |
| spatiotemporal frameworks for infectious disease diffusion and epidemiology. | emerging infectious diseases, and the resurgence of previously controlled infectious disease (e.g., malaria, tuberculosis), are a major focus for public health concern, as well as providing challenges for establishing aetiology and transmission. [...]. | 2016 | 27999420 |
| dengue fever-associated maculopathy and panuveitis in australia. | purpose. to describe a case of dengue fever-associated maculopathy and panuveitis to raise awareness of these ophthalmic complications of dengue in australia in the light of recent increasing numbers of outbreaks from equatorial through to tropical australia. case report. a 37-year-old caucasian australian male returning from cambodia presented with a bilateral dengue fever-associated maculopathy with left panuveitis diagnosed clinically and haematologically. automated perimetry revealed bilater ... | 2016 | 28078150 |
| cloning, expression, and characterization of prophenoloxidases from asian corn borer, ostrinia furnacalis (gunée). | insect phenoloxidase (po) belongs to the type 3 copper protein family and possesses oxidoreductase activities. po is typically synthesized as a zymogen called prophenoloxidase (ppo) and requires the proteolytic activation to function. we here cloned full-length cdna for 3 previously unidentified ppos, which we named ofppo1a, ofppo1b, and ofppo3, from asian corn borer, ostrinia furnacalis (gunée), in addition to the previously known ofppo2. these conceptual ppos and ofppo2 all contain two common ... | 2016 | 28078308 |
| data documenting the potential distribution of aedes aegypti in the center of veracruz, mexico. | the data presented in this article are related to the research article entitled "establishment of aedes aegypti (l.) in mountainous regions in mexico: increasing number of population at risk of mosquito-borne disease and future climate conditions" (m. equihua, s. ibáñez-bernal, g. benítez, i. estrada-contreras, c.a. sandoval-ruiz, f.s. mendoza-palmero, 2016) [1]. this article provides presence records in shapefile format used to generate maps of potential distribution of aedes aegypti with diffe ... | 2016 | 28054003 |
| economic report on the cost of dengue fever in vietnam: case of a provincial hospital. | dengue is a mosquito-borne viral illness with the world's fastest rate of infection. in 2014, vietnam had recorded 43,000 cases in 53 provinces, with 28 deaths. | 2016 | 28031723 |
| attempts to image the early inflammatory response during infection with the lymphatic filarial nematode brugia pahangi in a mouse model. | helminth parasites remain a major constraint upon human health and well-being in many parts of the world. treatment of these infections relies upon a very small number of therapeutics, most of which were originally developed for use in animal health. a lack of high throughput screening systems, together with limitations of available animal models, has restricted the development of novel chemotherapeutics. this is particularly so for filarial nematodes, which are long-lived parasites with a compl ... | 2016 | 27992545 |
| rna interference as a gene silencing tool to control tuta absoluta in tomato (solanum lycopersicum). | rna interference (rnai), a gene-silencing mechanism that involves providing double-stranded rna molecules that match a specific target gene sequence, is now widely used in functional genetic studies. the potential application of rnai-mediated control of agricultural insect pests has rapidly become evident. the production of transgenic plants expressing dsrna molecules that target essential insect genes could provide a means of specific gene silencing in larvae that feed on these plants, resultin ... | 2016 | 27994959 |
| variations on a theme: antennal lobe architecture across coleoptera. | beetles comprise about 400,000 described species, nearly one third of all known animal species. the enormous success of the order coleoptera is reflected by a rich diversity of lifestyles, behaviors, morphological, and physiological adaptions. all these evolutionary adaptions that have been driven by a variety of parameters over the last about 300 million years, make the coleoptera an ideal field to study the evolution of the brain on the interface between the basic bauplan of the insect brain a ... | 2016 | 27973569 |
| identification of development-related genes in the ovaries of adult harmonia axyridis (pallas) lady beetles using a time- series analysis by rna-seq. | adults of the lady beetle species harmonia axyridis (pallas) are bred artificially en masse for classic biological control, which requires egg-laying by the h. axyridis ovary. development-related genes may impact the growth of the h. axyridis adult ovary but have not been reported. here, we used integrative time-series rna-seq analysis of the ovary in h. axyridis adults to detect development-related genes. a total of 28,558 unigenes were functionally annotated using seven types of databases to o ... | 2016 | 27966611 |
| how do households respond to unreliable water supplies? a systematic review. | although the millennium development goal (mdg) target for drinking water was met, in many developing countries water supplies are unreliable. this paper reviews how households in developing countries cope with unreliable water supplies, including coping costs, the distribution of coping costs across socio-economic groups, and effectiveness of coping strategies in meeting household water needs. structured searches were conducted in peer-reviewed and grey literature in electronic databases and sea ... | 2016 | 27941695 |
| aphids transform and detoxify the mycotoxin deoxynivalenol via a type ii biotransformation mechanism yet unknown in animals. | biotransformation of mycotoxins in animals comprises phase i and phase ii metabolisation reactions. for the trichothecene deoxynivalenol (don), several phase ii biotransformation reactions have been described resulting in don-glutathiones, don-glucuronides and don-sulfates made by glutathione-s-transferases, uridine-diphosphoglucuronyl transferases and sulfotransferases, respectively. these metabolites can be easily excreted and are less toxic than their free compounds. here, we demonstrate for ... | 2016 | 27929076 |
| consecutive large dengue outbreaks in taiwan in 2014-2015. | 2016 | 27924810 | |
| transcriptomic characterization and curation of candidate neuropeptides regulating reproduction in the eyestalk ganglia of the australian crayfish, cherax quadricarinatus. | the australian redclaw crayfish (cherax quadricarinatus) has recently received attention as an emerging candidate for sustainable aquaculture production in australia and worldwide. more importantly, c. quadricarinatus serves as a good model organism for the commercially important group of decapod crustaceans as it is distributed worldwide, easy to maintain in the laboratory and its reproductive cycle has been well documented. in order to better understand the key reproduction and development reg ... | 2016 | 27924858 |
| retrospective analysis of prognostic factors in dengue infected patients with intracranial bleed. | dengue is one of the most common mosquito-transmitted arboviral disease of tropical and a few subtropical areas in the world. it is estimated that approximately 100 million cases occur per year and approximately 2.5 billion people are at risk of developing dengue infection. hemorrhagic complications causing encephalopathy are quite rare but fatal consequences of this deadly disease. this study was conducted to discuss the prognostic factors in the management of intracranial hemorrhage in dengue ... | 2016 | 28031986 |
| control of aedes aegypti breeding: a novel intervention for prevention and control of dengue in an endemic zone of delhi, india. | the study is based on hypothesis that whether continuous entomological surveillance of ae. aegypti and simultaneous appropriate interventions in key containers during non-transmission (december-may) months would have any impact on breeding of aedes and dengue cases during the following transmission months (june-november). the impact of the surveillance and intervention measures undertaken during non-transmission months were assessed by entomological indicators namely container index (ci), house ... | 2016 | 27918577 |
| beyond traditional antimicrobials: a caenorhabditis elegans model for discovery of novel anti-infectives. | the spread of antibiotic resistance amongst bacterial pathogens has led to an urgent need for new antimicrobial compounds with novel modes of action that minimize the potential for drug resistance. to date, the development of new antimicrobial drugs is still lagging far behind the rising demand, partly owing to the absence of an effective screening platform. over the last decade, the nematode caenorhabditis elegans has been incorporated as a whole animal screening platform for antimicrobials. th ... | 2016 | 27994583 |
| susceptibility of phytomonas serpens to calpain inhibitors in vitro: interference on the proliferation, ultrastructure, cysteine peptidase expression and interaction with the invertebrate host. | a pleiotropic response to the calpain inhibitor mdl28170 was detected in the tomato parasite phytomonas serpens. ultrastructural studies revealed that mdl28170 caused mitochondrial swelling, shortening of flagellum and disruption of trans golgi network. this effect was correlated to the inhibition in processing of cruzipain-like molecules, which presented an increase in expression paralleled by decreased proteolytic activity. concomitantly, a calcium-dependent cysteine peptidase was detected in ... | 2016 | 27925020 |
| size, sounds and sex: interactions between body size and harmonic convergence signals determine mating success in aedes aegypti. | several new mosquito control strategies will involve the release of laboratory reared males which will be required to compete with wild males for mates. currently, the determinants of male mating success remain unclear. the presence of convergence between male and female harmonic flight tone frequencies during a mating attempt have been found to increase male mating success in the yellow fever mosquito, aedes aegypti. size has also been implicated as a factor in male mating success. here, we inv ... | 2016 | 27906074 |
| clinical profiles of dengue infection during an outbreak in northern india. | introduction. dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (df), dengue hemorrhagic fever (dhf), dengue shock syndrome (dss), and expanded dengue syndrome (eds) with atypical presentations, thus posing a diagnostic dilemma. unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. we studied the various clinical presentations of dengue infection during ... | 2016 | 28025597 |
| path of infectious diseases in brazil in the last 50 years: an ongoing challenge. | in this article, we comment on the main features of infectious diseases in brazil in the last 50 years, highlighting how much of this path revista de saúde pública could portray. from 1967 to 2016, 1,335 articles focusing on infectious diseases were published in revista de saúde pública. although the proportion of articles on the topic have decreased from about 50.0% to 15.0%, its notability remained and reflected the growing complexity of the research required for its control. it is noteworthy ... | 2016 | 28099652 |
| contribution of oswaldo paulo forattini to public health: analysis of scientific production. | to analyze the main characteristics of the scientific production of oswaldo paulo forattini, researcher and, for 40 years, editor of revista de saúde pública. | 2016 | 28099651 |
| small rnas from bemisia tabaci are transferred to solanum lycopersicum phloem during feeding. | the phloem-feeding whitefly bemisia tabaci is a serious pest to a broad range of host plants, including many economically important crops such as tomato. these insects serve as a vector for various devastating plant viruses. it is known that whiteflies are capable of manipulating host-defense responses, potentially mediated by effector molecules in the whitefly saliva. we hypothesized that, beside putative effector proteins, small rnas (srna) are delivered by b. tabaci into the phloem, where the ... | 2016 | 27933079 |
| the worldwide spread of the tiger mosquito as revealed by mitogenome haplogroup diversity. | in the last 40 years, the asian tiger mosquito aedes albopictus, indigenous to east asia, has colonized every continent except antarctica. its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, west nile, and the recently emerged zika fever. to acquire more information on the ancestral source(s) of adventive populations and the overall diffusion process from its native range, we analyzed th ... | 2016 | 27933090 |
| amino acids trigger down-regulation of superoxide via torc pathway in the midgut of rhodnius prolixus. | sensing incoming nutrients is an important and critical event for intestinal cells to sustain life of the whole organism. the torc is a major protein complex involved in monitoring the nutritional status and is activated by elevated amino acid concentrations. an important feature of haematophagy is that huge amounts of blood are ingested in a single meal, which results in the release of large quantities of amino acids, together with the haemoglobin prosthetic group, haem, which decomposes hydrop ... | 2016 | 26945025 |
| immunodominant dengue virus-specific cd8+ t cell responses are associated with a memory pd-1+ phenotype. | dengue disease is a large public health problem that mainly afflicts tropical and subtropical regions. understanding of the correlates of protection against dengue virus (denv) is poor and hinders the development of a successful human vaccine. the present study aims to define denv-specific cd8(+)t cell responses in general and those of hla alleles associated with dominant responses in particular. in human blood donors in nicaragua, we observed a striking dominance of hla b-restricted responses i ... | 2016 | 26912627 |
| [hemorrhagic form of dengue fever observed at the infectious diseases department chu yalgado ouédraogo, burkina faso]. | dengue is a re-emerging arboviral disease in tropical countries. haemorrhagic form may be associated with circulatory failure and produce hypovolemic shock, which is often fatal. we report a series of three cases of hemorrhagic dengue observed at the infectious diseases department chu yalgado ouédraogo, ouagadougou, in order to describe its epidemiological, clinical, and evolutive characteristics. our study included young females who had an onset age of between 35 years and 45 years, residing in ... | 2016 | 27303584 |
| indole alkaloids of the stigonematales (cyanophyta): chemical diversity, biosynthesis and biological activity. | the cyanobacteria are well recognized as producers of a wide array of bioactive metabolites including toxins, and potential drug candidates. however, a limited number of taxa are generally considered with respect to both of these aspects. that said, the order stigonematales, although largely overlooked in this regard, has become increasingly recognized as a source of bioactive metabolites relevant to both human and environmental health. in particular, the hapalindoles and related indole alkaloid ... | 2016 | 27058546 |
| polyandry depends on postmating time interval in the dengue vector aedes aegypti. | aedes aegypti is the primary vector of the dengue and chikungunya viruses. after mating, male seminal fluid molecules cause females to become unreceptive to a subsequent mating. this response is often assumed to be immediate and complete, but a growing body of evidence suggests that some females do mate more than once. it is unknown how quickly a female becomes unreceptive to a second mating. furthermore, the degree to which she remains monandrous after laying several batches of eggs has not bee ... | 2016 | 26880776 |