| [a survey of angiostrongylus cantonensis in guangzhou]. | | 1984 | 6467537 |
| circumoval and circumlarval precipitate reactions of angiostrongylus cantonensis. | | 1984 | 6716749 |
| genetic variability in isozymes of angiostrongylus malaysiensis. | the genetic difference between angiostrongylus malaysiensis and a. cantonensis was assayed by electrophoretic analysis of isozymes. six enzymes were analyzed using 5% polyacrylamide gel electrophoresis. seven of 10 loci, namely gpi-1, gpi-2, hk-1, hk-2, mdh-1, mdh-2 and pgm-2, were shown to be polymorphic, but the remaining 3 loci, ldh, me and pgm-1, were not. both a. malaysiensis and a. cantonensis were polymorphic at 6 of the loci (p = 0.600) with heterozygosity h of 0.286 and 0.151, respectiv ... | 1994 | 7667723 |
| comparative infectivity and survival of first-stage larvae of angiostrongylus cantonensis and angiostrongylus malaysiensis. | angiostrongylus malaysiensis was isolated from wild rats rattus norvegicus in a seaport area of kitakyushu city, kyushu, japan in 1990. the infectivity and survival capacities of first-stage larvae of a. malaysiensis and angiostrongylus cantonensis were compared under various conditions. infectivity of first-stage larvae of the former in biomphalaria glabrata was much lower than that of the latter. in an exposure at various phs, and with various proteases and tissue homogenates of b. glabrata, t ... | 1995 | 7707198 |
| ultrastructural evidence for eosinophil-mediated destruction of angiostrongylus cantonensis transferred into the pulmonary artery of non-permissive hosts. | ultrastructural and cytochemical analyses were carried out on cellular reactions to the young adult worms of angiostrongylus cantonensis surgically transferred into the pulmonary arteries of permissive (rat) and non-permissive (rabbit and guinea-pig) hosts. in permissive hosts, no appreciable cellular reactions could be found around worms throughout the course of the observations. by contrast, the infiltration of neutrophils along with eosinophils was observed around worms in non-permissive host ... | 1984 | 6718049 |
| parasitic infections of the central nervous system in children. part i: congenital infections and meningoencephalitis. | this review article presents the epidemiology, pathogenesis, clinical presentation, laboratory and radiologic findings, and treatment of parasitic infections of the central nervous system in children. some obscure parasitic infections are included. to assist the clinician faced with a specific case, infections are categorized first by predominant clinical manifestations: congenital disease, meningoencephalitis, focal lesions, and disseminated multisystem disease. within the clinical categories, ... | 1995 | 7769177 |
| occurrence of the infective stage of angiostrongylus cantonensis in the yellow tree monitor (varanus bengalensis) in five provinces of thailand. | twenty-two yellow tree monitors (varanus bengalensis) were trapped and transported from 5 provinces, namely lampang, phitsanulok, kamphaeng phet, tak and prachin buri to look for the infective larvae stage of angiostrongylus cantonensis. in 4 provinces all of the yellow tree monitors were infected with the infective stage larvae of a. cantonensis altogether. twenty-one of the 22 yellow tree monitors (95.5%) in the five provinces were infected. our results of this study extend our knowledge of na ... | 1994 | 7777915 |
| immunological regulation of angiostrongylus cantonensis infections in rats: modulation of population density and enhanced parasite growth following one or two superimposed infections. | rats acquired a degree of protective immunity to reinfection with angiostrongylus cantonensis after a single infection with 50 infective larvae. infected rats resisted the establishment of most challenging larvae and protective immunity increased with subsequent reinfections. part of the primary infection was lost after a superimposed second and also following a superimposed third infection, but the total size of the concurrent adult worm populations remained the same as that from a primary infe ... | 1983 | 6875253 |
| parasite density and the fecundity of angiostrongylus cantonensis in rats. | the larval output of angiostrongylus cantonensis at different initial densities in rats was examined throughout the reproductive life-span of the worms using a modified dilution technique. with an initial density of 2 worms the mean duration of larval output was 414.2 days. the output was at a level above 50000 larvae/female/day from 15 to 45 weeks after infection. the mean total output was 18.9 x 10(6) larvae/female. the larval output/female decreased with an increase in the worm burden and als ... | 1984 | 6504559 |
| [eosinophilic meningitis (angiostrongyloidosis). dangers of asian cooking]. | | 1995 | 7899375 |
| severe forms of infection with angiostrongylus cantonensis acquired in australia and fiji. | | 1994 | 7980247 |
| a probable case of ocular angiostrongyliasis in new britain, papua new guinea. | unilateral iritis, keratitis and episcleritis presented in a 45-year-old female melanesian from new britain, papua new guinea. a motile nematode was seen in the anterior vitreous but was not recovered. inflammation resolved with topical corticosteroid and antibiotic treatment, but visual impairment persisted. she failed to return for repeat serology after discharge, and measurement of serum antibody levels to angiostrongylus cantonensis in the single specimen obtained, using the direct and indir ... | 1982 | 6926775 |
| angiostrongylus cantonensis in east new britain, papua new guinea. | the first case of angiostrongyliasis (eosinophilic meningitis) to be diagnosed in papua new guinea in 1977, led to a survey of adult melanesian residents of east new britain province where the case occurred, to assess the level of immunological responsiveness to angiostrongylus cantonensis. in 104 subjects tested using an indirect fluorescent antibody test, the serum antibody titres to a. cantonensis equalled or exceeded 1:16 in 50.7% and ranged from 1:32 to 1:64 in 17.3% of subjects. no individ ... | 1984 | 6533849 |
| [detection of serum antibodies in rats infected with angiostrongylus cantonensis by indirect fluorescent antibody test]. | frozen section specimens with a thickness of 4 microns were made from adult worms of angiostrongylus cantonensis in order to detect the serum antibodies in rats infected with angiostrongylus cantonensis by indirect fluorescent antibody test (ifat). the results showed that the positive rates of the serum samples 2 and 4 weeks after infection were 92.0% (46/50) and 100%(19/19), respectively. the results of serum samples in healthy rats and normal saline (as control) were negative. this technique p ... | 1993 | 8082269 |
| eosinophilic meningitis due to angiostrongylus cantonensis. | | 1993 | 8123100 |
| the course of angiostrongylus cantonensis infection in athymic nude and neonatally thymectomized mice. | balb/c athymic nude and thymus-reconstituted nude mice and neonatally thymectomized balb/c mice were infected with stage 3 larvae of angiostrongylus cantonensis and the worm burdens of the mice were determined at various times after infection. when the nude and thymectomized mice were exposed to the parasite, some worms were found to migrate from the brain to lungs but died there without reaching maturity. this pulmonary arterial migration of the worms in the nude did not occur following thymic ... | 1982 | 6981266 |
| eosinophilic meningitis. | | 1993 | 8279176 |
| cryopreservation of angiostrongylus cantonensis third-stage larvae. | an optimum protocol for the cryopreservation of third-stage larvae (l3) of angiostrongylus cantonensis was determined by: (i) use of different dimethyl sulphoxide (dmso) concentrations; (ii) use of different fbs concentrations in rpmi-1640 medium; and (iii) variation in the thawing temperature. studies showed that with concentrations of dmso at 4.8% and fbs at 40% and a thawing temperature of 43 degrees c, l3 survival assessed by motility was highest at 56%. the infectivity of the cryopreserved ... | 1993 | 8288855 |
| effect of irradiation on the viability of angiostrongylus cantonensis and a. costaricensis infective larvae. | infective larvae (third-stage larvae) of both angiostrongylus cantonensis and a. costaricensis from their snail intermediate host were subjected to either x-ray or gamma-ray irradiation. the viability of the irradiated larvae was assayed by oral inoculation of the larvae into rodents (a. cantonensis in mice and rats, a. costaricensis in mice only). from the results of worm recovery, the minimal dose of irradiation that inhibited the infectivity of the third-stage larvae of a. cantonensis and a. ... | 1993 | 8288856 |
| [finding of angiostrongylus cantonensis in the cerebrospinal fluid of a boy with eosinophilic meningoencephalitis]. | | 1981 | 7034073 |
| elisa for the detection of angiostrongylus cantonensis antibodies in patients with eosinophilic meningitis. | the enzyme-linked immunosorbent assay (elisa) was used to examine sera from twelve taiwanese children with eosinophilic meningitis suspected to be induced by infection with angiostrongylus cantonensis. polystyrene tubes were coated with angiostrongylus cantonensis antigens (5 micrograms/ml protein) prepared from fourth-stage larvae recovered from the brains of experimentally infected rats. alkaline phosphatase labelled goat antihuman igg conjugate was used in a dilution of 1 to 500; sera were di ... | 1982 | 7051339 |
| killing effect of gamma irradiation on angiostrongylus cantonensis in snails. | cobalt-60 gamma irradiation was used to kill the larvae of angiostrongylus cantonensis in four groups of snails that were irradiated at a rate of 15.4 gy/min for 16.23 min (0.25 kgy), 32.47 min (0.50 kgy), 48.70 min (0.75 kgy), and 64.94 min (1.00 kgy), respectively. third-stage (infected stage) larvae were isolated from these snails and 50 were administered to each experimental animal via an esophageal tube. at a dosage of 0.25 kgy, the mean +/- sd number of worms recovered from 30 rats and 30 ... | 1993 | 8333577 |
| ablation of eosinophils with anti-il-5 antibody enhances the survival of intracranial worms of angiostrongylus cantonensis in the mouse. | effects of depressed eosinophilia on the development of angiostrongylus cantonensis in the mouse were studied using monoclonal rat anti-mouse-interleukin-5 antibody (anti-il-5). the administration of anti-il-5 strongly depressed peripheral, cerebrospinal fluid (csf) and medullary eosinophilic responses in mice infected with a. cantonensis, when compared with groups treated with phosphate-buffered saline solution (pbs) alone or isotype-matched rat igg. there was no significant difference in a. ca ... | 1993 | 8361777 |
| pathways of pyrimidine nucleotide biosynthesis in gravid angiostrongylus cantonensis. | the incorporation of radioactive precursors into pyrimidine nucleotides via de novo and salvage pathways was measured in gravid angiostrongylus cantonensis by hplc and thin-layer chromatography. 14c-labelled orotate, uridine, uracil and deoxyuridine were traced to ump, udp, utp, udp-glucose, dtmp, cmp, cdp and ctp. 3h-labelled cytidine was also incorporated into both uracil and cytosine nucleotides in a ratio of 2:1. cytosine was a major end-product for all the precursors. cytosine nucleotides w ... | 1993 | 8366894 |
| eosinophilic meningitis and hydrocephalus in an infant. | central nervous system invasion by helminths is the most frequent cause of eosinophilic pleocytosis in the csf. although csf eosinophilia is an unusual finding in the continental united states, it is not an uncommon observation in cases of meningitis in hawaii and the south pacific. the rat lungworm, angiostrongylus cantonensis has been implicated as the causal agent responsible for cases of eosinophilic meningitis in these areas. the diagnosis of eosinophilic meningitis secondary to a cantonens ... | 1982 | 7092618 |
| angiostrongylus cantonensis: biogenic amines in the lungs of infected rats. | | 1982 | 7095071 |
| host-parasite relationship of angiostrongylus cantonensis. 2. angiotropic behaviour and abnormal site development. | migratory young fifth-stage angiostrongylus cantonensis transplanted intracranially into recipient rats were found to reach the lungs 3-4 days later by randomly entering cerebral veins. however, worms which were transplanted close to extracranial veins such as the jugular and femoral veins, or into the pleural and peritoneal cavities failed to enter these blood vessels. third-stage larvae were capable of infecting rats via skin wounds. protease activity was not detected around young fifth and th ... | 1981 | 7210820 |
| phospholipase b in the brains and meninges of nonsensitized and sensitized rats after challenge with angiostrongylus cantonensis. | after a primary infection with 100 angiostrongylus cantonensis larvae, infected rats showed elevated phospholipase b activity in meningeal and brain homogenates beginning with the first week and continuing through the first month of infection. the rise in phospholipase b values through the first 4 weeks, with a prolonged peak spanning days 30 to 31, coincided with the invasion and maturation of the parasites in the brain, and the ensuing sharp decline in phospholipase b levels, shown by the read ... | 1980 | 7216437 |
| eosinophilic meningoencephalitis in cuba, caused by angiostrongylus cantonensis. | five cases of eosinophilic meningoencephalitis presumed to be caused by the rat lungworm, angiostrongylus cantonensis, are reported from localities in or near havana, cuba. the first typical case occurred in 1973. lungworms identified as a. cantonensis were found in rats from the same localities. the clinical picture in the cuban cases, as in cases from other countries, is that of a self-limiting disease without apparent sequelae. | 1981 | 7283014 |
| l ferritin accumulation in macrophages infiltrating the lung during rat angiostrongylus cantonensis infection. | a 22-kda protein was increased quantitatively, as measured by sodium dodecyl sulfate-polyacrylamide gel electrophoresis techniques, in lung microsomes prepared from angiostrongylus cantonensis-infected rats. however, it was almost absent in normal rats. the protein was purified by sequential chromatography on superdex 200 columns and identified chemically and immunologically as ferritin. using isoelectric focusing and anion exchange chromatography, it was identified as l ferritin. distribution o ... | 1996 | 8654551 |
| [ingestion of raw fish: a cause of eosinophilic meningitis caused by angiostrongylus cantonensis after a trip to tahiti]. | | 1996 | 8685114 |
| first record of angiostrongylus cantonensis in cuba. | the occurrence of human eosinophilic meningoencephalitis in several localities of havana, cuba, prompted a search for the rat lungworm, angiostrongylus cantonensis, in the same localities. twenty rats (rattus norvegicus) and about 370 terrestrial mollusks (70 slugs, veronicella cubensis, and about 300 snails, mostly bradybaena similaris) were collected in six communities of the province of havana, and in the gardens of the pedro kouri institute for tropical medicine in havana city. adult lungwor ... | 1981 | 7283015 |
| angiostrongylus cantonensis: development following pulmonary arterial transfers into permissive and nonpermissive hosts. | | 1980 | 7371736 |
| acid phosphatase activity demonstrated in the nematodes, dirofilaria immitis and angiostrongylus cantonensis with special reference to the characters and distribution. | acid phosphatase activity was demonstrated in the intact blood nematodes, dirofilaria immitis and angiostrongylus cantonensis. biochemical studies on acid phosphatase, using intact females and whole worm, body-wall and visceral homogenates were undertaken to clarify the characteristics and the distribution of the enzyme. in d. immitis, high acid phosphatase activity was observed at ph 3.8--5.8 and in a. cantonensis, at ph 4.5--6.0. molybdate, fluoride, copper and zinc ions and l(+)-tartate were ... | 1980 | 7383707 |
| the cellular responses in marisa cornaurietis experimentally infected with angiostrongylus cantonensis. | the cellular responses in the poorly susceptible ampullariid snail marisa cornaurietis to angiostrongylus cantonensis, during a period of 40 days, involved focal and generalized proliferative reactions. the focal reactions appeared around all larvae as accumulations of variable numbers of amoebocytes at 24 h after infection in the loose connective tissues and somewhat later in the dense tissues. this cellular infiltration intensified gradually with time leading to the encapsulation of the parasi ... | 1980 | 7395311 |
| carbohydrate reserves and hemolymph sugars of the african giant snail, achatina fulica in relation to parasitic infection and starvation. | in the snail, achatina fulica, parasitized by the rat lungworm angiostrongylus cantonensis, levels of carbohydrate in hemolymph and digestive glands were determined. the normal level of hemolymph glucose of 11.7 mg% dropped to 4.25 mg% in the infected snails, a significant difference after only one week of infection. the level of total reducing sugar in the hemolymph also decreased significantly (12.3 mg% to 3.6 mg%) in this period. later on, the snails were capable of adapting themselves to the ... | 1980 | 7415419 |
| [eosinophil meningoradiculitis caused by angiostrongylus cantonensis]. | the authors report the case of a 46-year-old woman who presented with an eosinophilic meningoradiculits after a trip to tahiti. because of the type of presentation of the symptomatology, the csf findings, and the spontaneously favourable outcome, it was related to an infection by angiostrongylus cantonensis. the authors review the neurological manifestations of this parasite and emphasize the different clinical aspects of infection by gnathostoma spinigerum, which causes myeloencephalitis in the ... | 1995 | 7481397 |
| induction of cerebrospinal fluid eosinophilia in rats by the intraventricular injection of angiostrongylus cantonensis antigen. | resistance to angiostrongylus cantonensis is contingent upon the generation of an eosinophilic response in the csf of infected hosts. we have studied the parameters required for the generation of this csf eosinophilia in normally permissive rats. we initially induced a marked peripheral eosinophilia in rats by infection with either mesocestoides corti or angiostrongylus cantonensis or the surgical transfer of a. cantonensis young adult worms (ya) into their pulmonary arteries. next, we injected ... | 1997 | 9076536 |
| the susceptibility of five stains mice to infections with angiostrongylus cantonensis. | the susceptibility to the infection of angiostrongylus cantonensis was studied in five inbred stains of mice including four h-2 haplotypes. three weeks after infection, c57 bl/10j (h-2b) and c57bl/6j (h-2b) stains of mice showed the lowest, cba (h-2k) and a/j (h-2a) stains showed intermediate, and the balb/cj (h-2d) mice showed the greatest susceptibility to infection. balb/cj mice also displayed the most body weight loss, the highest number of worms and showed the least number of days of surviv ... | 1995 | 7490792 |
| [angiostrongylus cantonensis in madagascar]. | | 1982 | 7186336 |
| experimental infection of five subspecies of oncomelania snails with angiostrongylus cantonensis. | five subspecies of oncomelania snails, oncomelania hupensis nosophora, o.h. hupensis, o.h.chiui, o.h.formosana and o.h.quadrasi, were experimentally exposed to the first stage larvae of angiostrongylus cantonesis. the presence of third stage larvae was observed in all of the five subspecies of oncomelania snails 20 days after infection. infection rates of the third stage larvae of the parasite in oncomelania snails were 38.0-40.0%. there were no differences in preferences among oncomelania snail ... | 1995 | 9139392 |
| detection of circulating antigen by monoclonal antibodies for immunodiagnosis of angiostrongyliasis. | two monoclonal antibodies, which recognize the epitope on an antigen with a molecular weight of 204 kd from the fifth-stage worm of angiostrongylus cantonensis, were previously prepared and used to detect circulating antigens in patients with eosinophilic meningitis or meningoencephalitis and in mice experimentally infected with this parasite by a double-antibody, sandwich enzyme-linked immunosorbent assay (elisa). the levels of this circulating antigen in experimentally infected mice were signi ... | 1997 | 9158049 |
| seroepidemiology of five major zoonotic parasite infections in inhabitants of sidoarjo, east java, indonesia. | we conducted a seroepidemiological survey of zoonotic parasite infection in inhabitants of east java, indonesia. the subjects of the survey were 244 persons selected from visitors to sidoarjo city hospital in east java between may 1992 and october 1993. ninety-seven had diarrhea and the rest came to the hospital for routine check-ups. all serum samples were tested for antibodies against five zoonotic parasites: toxoplasma gondii, entamoeba histolytica, toxocara canis. angiostrongylus cantonensis ... | 1996 | 9185269 |
| [studies on chemotherapy of parasitic helminths (iv). effects of alkaloids from sophora flavescens on the motility of parasitic helminths and isolated host tissues (author's transl)]. | effects of n-methylcytisine (n-mc) and matrine (mat), alkaloids from sophora flavescens on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) the motility of angiostrongylus cantonensis was affected spastically by n-mc (1.2 x 10(-6) approximately 1.2 x 10(-4) m), but paralytically by mat (10(-5) approximately 10(-4) m). 2) the motility of dipylidium caninum and fasciola hepatica was affected paralytically by n-mc (1.2 x 10(-4) approximately 1.2 x 10(-3) ... | 1982 | 7200047 |
| eosinophilia and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor alpha chain-knockout mice infected with angiostrongylus cantonensis. | we infected interleukin-5 (il-5)-transgenic (il-5-tg) and il-5 receptor alpha knockout (il-5r alpha -/-) mice with angiostrongylus cantonensis to determine the possible roles of il-5 and eosinophils in a. cantonensis infection in mice. il-5-tg mice demonstrated significantly higher eosinophilia in bone marrow, blood and cerebrospinal fluid (csf), lower intracranial worm recovery and smaller female worms than naive c3h/hen mice. both il-5-tg and c3h/hen mice evoked antigen-specific serum and csf ... | 1997 | 9211511 |
| detection of antibodies to surface antigens of angiostrongylus cantonensis by elisa. | | 1995 | 7495370 |
| more on angiostrongylus cantonensis infection. | | 1995 | 7651497 |
| stage-specific gene expression in angiostrongylus cantonensis: characterisation and expression of an adult-specific gene. | we have previously used differential mrna display to identify and clone a range of cdnas derived from genes expressed in only one developmental stage of angiostrongylus cantonensis. in this paper we report the characterisation of a gene designated ac-fmp-1 and its product, expressed only in the adult stage. full length cdna of 1.5 kb terminates at the 5' end with the conserved nematode spliced leader (sl) sequence and contains one open reading frame coding for a putative protein of 417 amino-aci ... | 1997 | 9274869 |
| the evaluation of the 29 and 31 kda antigens in female angiostrongylus cantonensis for serodiagnosis of human angiostrongyliasis. | the objective of this study was to evaluate the crude somatic extract of female angiostrongylus cantonensis by elisa and to evaluate the 29 kda and the 31 kda components of female worm by eitb for serodiagnosis of human angiostrongyliasis. using elisa, cross reaction occurred among all sera tested except capillariasis. the sensitivity, specificity, positive and negative predictive values of elisa were found to be 100%, 66.8%, 27.1% and 100% respectively. using eitb, the 29 kda component cross-re ... | 1996 | 9279992 |
| neural angiostrongylosis in three captive rufous bettongs (aepyprymnus rufescens). | neurological disease attributed to migration of the rat lungworm (angiostrongylus cantonensis), is described in three captive rufous bettongs (aepyprymnus rufescens). clinical signs, including ascending paralysis and multifocal neurological deficits, were similar to those seen in other species. histologically, the severity of meningoencephalomyelitis ranged from mild to moderate. in one animal cerebrospinal fluid contained a high percentage of eosinophils but peripheral blood cell counts were wi ... | 1997 | 9293336 |
| orphon spliced-leader sequences form part of a repetitive element in angiostrongylus cantonensis. | in nematodes, the 22 nucleotide (nt) spliced leader (sl) is normally encoded by a multi-copy, tandemly reiterated sl gene and is trans-spliced from sl-rna onto the 5' end of a subset of mrnas. we have found that the sl is also encoded at multiple (> 100) orphon genomic sites in the parasitic nematode angiostrongylus cantonensis. at these sites the sequence forms part of a 198 bp repetitive element (designated con-198). transcription from two genomic elements that contain the con-198 sequence has ... | 1995 | 7731790 |
| anthelmintic effect of levamisole against angiostrongylus cantonensis in mice. | levamisole, in dosages of 2.5, 5, 10, and 25 mg/kg/day, was given orally by orogastric tube beginning 5, 10, 15, and 20 days after the infection of icr mice with 50 third-stage larvae of angiostrongylus cantonensis. medication was given for 7, 14 or 21 consecutive days. the mice in each group were sacrificed 3 days after cessation of treatment and the brains were examined for parasites. complete anthelmintic effects could be obtained when treatment was started 10 days post-infection with dosages ... | 1994 | 7807609 |
| [occurrence of achatina fulica bowdich, 1822 (mollusca, gastropoda) in brazil: intermediate snail host of angiostrongyliasis]. | achatina fulica, the intermediate snail host of angiostrongyliasis and also an agricultural pest, is being bred in brazil for human consumption as "escargot". the snail has escaped from its artificial breeding sites and its dispersal in itariri country, state of s. paulo, is reported here for the first time. a. fulica is a transmitter of the rat lungworm angiostrongylus cantonensis, nematode which causes meningoencephalic angiostrongyliasis; the risks of human contamination are commented on. | 1997 | 9515269 |
| angiostrongylus cantonensis infection from eating raw snails. | | 1995 | 7898546 |
| cerebrospinal angiostrongyliasis in five captive tamarins (sanguinus spp). | four cotton-top tamarins (sanguinus oedipus oedipus) and one emperor tamarin (s imperator subgrisescens) housed in a zoo became depressed, anorexic, paraparetic and eventually paralysed. the animals died within 5 days to 18 months of the appearance of clinical signs. histological examination showed nonsuppurative and eosinophilic meningoencephalitis, and metastrongyle nematode larvae were found within subarachnoid spaces of all animals and within the spinal cord of one. intact larvae with featur ... | 1998 | 9578750 |
| angiostrongylus cantonensis: characterization of thymidylate synthetase. | thymidylate synthetase (ts) is the only enzyme that catalyzes the formation of thymidine nucleotides in angiostrongylus cantonensis. a fraction enriched in ts was obtained from the gravid nematode by gel filtration and affinity chromatography using methotrexate-agarose. ts, which was well separated from dihydrofolate reductase, has a relative molecular mass of 66 kda. by electrophoresis in sodium dodecyl sulphate gel, a major protein band corresponding to 31 kda was observed. this band was shown ... | 1994 | 8001663 |
| [2 murine angiostrongyliasis in the caribbean and their human consequences: a menace for haiti?]. | | 1997 | 9612787 |
| [effect of the anthelminthic levamisole on the first-stage larva of angiostrongylus cantonensis in infected rats]. | effects of levamisole, orally administered at 1, 3, 5 or 7 successive daily doses of 30 mg/kg, on the number of first-stage larvae of angiostrongylus cantonensis released in the faeces of treated rats were examined. first-stage larval counts (larvae per gram of faeces per female worm recovered, lpg/female) were conspicuously reduced 1 day after administration in all treated groups. in the group treated with a single dose, the larval counts increased 2 days after administration, but no larvae cou ... | 1994 | 8036245 |
| a survey of helminth infection in rats (rattus spp) from chiang mai moat. | an investigation of helminths in the norway (brown) rat, rattus norvegicus, and roof rat, rattus rattus, from chiang mai moat during may to august 1995, was done. thirty-three out of thirty-eight trapped rats were infected (86.84%); 16 r. norvegicus (100%) and 17/22 r. rattus (77.27%). the rat was infected with 10 helminth species: 4 trematodes, centrocestus sp (2.63%), echinostoma ilocanum (10.52%), echinostoma malayanum (10.52%) and quinqueseralis quinqueseralis (39.47%); 2 cestodes, raillieti ... | 1997 | 9656373 |
| angiostrongylus infections in rats and snails in northeast thailand. | a survey of angiostrongylus infections in rats and snails was carried out in the provinces of ubon ratchathani, udon thani. kalasin, chaiyaphum and khon kaen in northeast thailand. only two rattus norvegicus (3.8%) and one bandicota indica (1.4%) out of 151 r. rattus, 52 r. norvegicus and 69 b. indica examined were infected with adult lung worms. all worms recovered were a. cantonensis. prevalence of infection in 423 pila polita was 0.9% while all of 77 p. ampullacea were negative for larvae. in ... | 1997 | 9656375 |
| intrathecal synthesis of immunoglobulins in eosinophilic meningoencephalitis due to angiostrongylus cantonensis. | eosinophilic meningoencephalitis due to the nematode angiostrongylus cantonensis, which is endemic to cuba, occurs in children and is due to accidental contact with soil snails. the course is less often fatal than in adult patients in southeastern asia. cerebrospinal fluid (csf) and serum samples from 24 pediatric patients were analyzed and evaluated in csf/serum quotient diagrams (reiber graphs) to characterize the neuroimmunological response and the blood-csf barrier dysfunction that occur in ... | 1998 | 9665947 |
| [eosinophilic meningitis due to angiostrongylus cantonensis]. | angiostrongylus cantonensis is the most common etiological agent of eosinophilic meningitis. adults are harbored in the pulmonary arteries of rats. larvae develop within various natural (mollusks) and paratenic (snails...) hosts. after ingestion, larvae reach the human central nervous system where they cannot complete their life cycle. this zoonosis is usually seen in southeast asia and south pacific islands. nevertheless, a few imported cases have been reported in western countries, possible be ... | 1998 | 9773048 |
| [meningoencephalomyelitis due to angiostrongylus cantonensis with lung involvement]. | | 1998 | 9803560 |
| eosinophilic meningitis/angiostrongyliasis from eating aquaculture-raised snails: a case report. | | 1998 | 9844300 |
| [laboratory diagnosis of protozoan and parasitic infections. 2. helminthiasis. f. angiostrongyliasis cantonensis]. | | 1998 | 9921258 |
| improvements in the infectivity of cryopreserved third-stage larvae of angiostrongylus cantonensis using a programmable freezer. | although there have been some advances in the cryopreservation of angiostrongylus cantonensis, the degrees of viability and infectivity of the cryopreserved developmental stages have not been high. a two-step freezing protocol using a programmable freezer was determined to be effective in improving the infectivity of the cryopreserved third-stage larvae of this parasite. after washing steps and suspension in 10% (v/v) dimethylsulfoxide and equilibrium at room temperature the larvae were placed i ... | 1999 | 9934966 |
| [angiostrongyliasis]. | | 1999 | 10201262 |
| parasitic meningitis. | | 1999 | 10397038 |
| a fatal case of angiostrongyliasis in an 11-month-old infant. | an 11-month-old boy developed flaccid quadriparesis after two months in fiji, and was transferred to australia, where a diagnosis of postinfectious myelitis was made. despite peripheral blood eosinophilia, eosinophils were not detected in the cerebrospinal fluid, and an infective aetiology was not identified. the patient died of progressive bulbar dysfunction. at autopsy, numerous nematodes, identified as angiostrongylus cantonensis, were seen in vessels of the lungs, brain and spinal cord, asso ... | 1999 | 10397046 |
| [eosinophilic meningitis and meningoencephalitis in children]. | eosinophilic meningitis or meningoencephalitis is a disease commonly seen in taiwan, especially in children during the summer rainy season. most of the cases reported in other countries were adults and their clinical manifestations were different from children. studies on special clinical characteristics among 87 children in taiwan were performed. thirty-eight (43.7%) were male and 49 (56.3%) females, and 88.5% could be traced to a history of contact with the intermediate host, the giant african ... | 1994 | 8184688 |
| the effect of cyclosporin a on angiostrongylus cantonensis infection and eosinophilia in mice. | male balb/c mice were infected with angiostrongylus cantonensis and at various times p.i. treated with cyclosporin a (csa) either for 5 days continuously or intermittently, or for 12-16 days on alternate days. they were monitored for peripheral blood eosinophilia and at necropsy examined for csf and bone marrow eosinophilia, and worm recovery. csa treatment provoked a transient inhibition of peripheral blood eosinophilia in all groups examined, followed by rebounding eosinophilia. there was no s ... | 1993 | 8300308 |
| angiostrongylus cantonensis infection in grey-headed fruit bats (pteropus poliocephalus). | | 1999 | 10451735 |
| angiostrongylus cantonensis eosinophilic meningitis. | in the past 50 years, angiostrongylus cantonensis, the most common cause of eosinophilic meningitis, has spread from southeast asia to the south pacific, africa, india, the caribbean, and recently, to australia and north america, mainly carried by cargo ship rats. humans are accidental, "dead-end" hosts infected by eating larvae from snails, slugs, or contaminated, uncooked vegetables. these larvae migrate to the brain, spinal cord, and nerve roots, causing eosinophilia in both spinal fluid and ... | 1999 | 10460929 |
| [severe forms of eosinophilic meningitis in infants of mayotte. apropos of 3 cases]. | eosinophilic meningitis caused by angiostrongylus cantonensis is widespread in southeast asia and the pacific islands. adults develop transient meningitis with a benign course, whilst severe or fatal disease may occur in pediatric patients. | 1999 | 10472441 |
| antigen dependent release of interleukin 5 in vitro from spleen cells of mice infected with angiostrongylus cantonensis. | the kinetics of eosinophil growth and/or survival stimulating factors (eo-stimulating factors) released by spleen cells from a. cantonensis-infected mice were assessed by in vitro marrow cultures. when spleen cells from c57bl/6 mice 8 to 20 days p.i. were cultured with young adult a. cantonensis worm antigen or con a, almost equal amounts of eo-stimulating factors were detected in the conditioned media obtained from both stimulations. no eo-stimulating factor activity was detected in cultures fr ... | 1993 | 8314370 |
| [mechanism of parasite killing by eosinophils in parasitic infections]. | eosinophils kill a variety of helminth parasites and some protozoan parasites in vitro by antibody- or complement-dependent mechanisms. nevertheless, direct evidence of in vivo parasite killing by eosinophils is scanty. in angiostrongylus cantonensis infection in non-permissive hosts, however, the intracranial worms are killed by eosinophils in the cerebrospinal fluid, indicating that the cells are associated, not only with the protective immunity against helminthic infections, but also with the ... | 1993 | 8492440 |
| horizontal conjugate gaze palsy in eosinophilic meningitis. | two cases of eosinophilic meningitis who presented with headache and strabismus are reported. pertinent physical examination revealed unilateral horizontal conjugate gaze palsy with absence of doll's eye maneuver and hemiparesis. the etiologic agent of eosinophilic meningitis is presumed to be angiostrongylus cantonensis and the infected location that produce horizontal conjugate gaze palsy was a pontine lesion. | 1999 | 10774676 |
| schistosoma japonicum in the black rat, rattus rattus mindanensis, from leyte, philippines in relation to oncomelania snail colonies with reference to other endoparasites. | this study examined the prevalence of schistosoma japonicum infections in field rats, rattus rattus mindanensis, according to different trapping locations. between october 1995 and january 1996, traps were set in the municipality of palo, leyte, philippines to determine the correlation of rats infected with schistosomiasis to the proximity of the intermediate snail host, oncomelania hupensis quadrasi, colonies. of the 22 rats that were caught within a snail colony, 21 (95.5%) were positive for s ... | 1999 | 10774707 |
| successful management of pain syndrome due to angiostrongylus cantonensis by implantable spinal cord stimulator. | | 1999 | 10868540 |
| effects of pf1022a on adult angiostrongylus cantonensis in the pulmonary arteries and larvae migrating into the central nervous system of rats. | we examined the effects of pf1022a, newly developing in japan, on adult angiostrongylus cantonensis in the pulmonary arteries of rats. following five and ten successive oral doses at 10 mg/kg per day, the first-stage larvae in rat faeces disappeared completely at 2 weeks after treatment. the treatment completely killed the female worms, but not the male worms. however, numbers of male worms were also decreased after the administration of either five successive oral doses at 10 mg/kg per day for ... | 1995 | 8570576 |
| defective b-1 cell development and impaired immunity against angiostrongylus cantonensis in il-5r alpha-deficient mice. | we generated interleukin-5 receptor alpha chain (il-5r alpha)-deficient (il-5r alpha-/-) mice by gene targeting. the il-5r alpha-/- mice showed decreased numbers of b-1 cells concomitant with low serum concentrations of igm and igg3. they showed no il-5-induced enhancement of b cell responses to t-independent antigens. the number of alpha beta t cell receptor-positive thymocytes tended to decrease in 3-week-old il-5r alpha-/- mice, returning to normal by 6 weeks of age. the il-5r alpha-/- mice p ... | 1996 | 8630733 |
| [parasitic infections among wild rats from two areas of kaohsiung]. | wild rats including four strains were captured for examination of parasitic infections. the numbers were 101 from areas of kaohsiung harbor and 98 from areas of kaohsiung airport. most of the examined wild rats were rattus norvegicus and second most were suncus murinus. the infection rates of intestinal helminths in rats of both areas did not display any significant difference. the overall infection rate was 29.6%. the infection rate was highest in r. norvegicus and the most frequently found par ... | 1996 | 8709181 |
| eosinophilic meningitis. is angiostrongylus cantonensis endemic in jamaica? | | 1996 | 8772400 |
| mediastinal lymph node cells of angiostrongylus cantonensis-infected rats respond to antigens and release interleukin-5 in vitro. | the kinetics of eosinophil growth and/or survival stimulating factor (eo-stimulating factor) production in angiostrongylus cantonensis-infected rats was assessed by in vitro marrow cultures. when lymphocytes, obtained from cervical, mediastinal or mesenteric lymph nodes of infected wkah rats, were cultured with a. cantonensis antigens, eo-stimulating factor activity was detected in the conditioned media obtained only from mediastinal lymph node cells at and after 35 days p.i. eo-stimulating fact ... | 1996 | 8818735 |
| role of t cell subpopulations in mice infected with angiostrongylus cantonensis. | when c57bl/6 mice were infected with angiostrongylus cantonensis, the percentage of t helper (cd4+) cells and t supressor (cd8+) cells in peripheral blood increased weekly until the third and seventh week respectively, and then gradually decreased. c57bl/6 mice were depleted of cd4+ and cd8+ t cells by in vivo injection of anti-cd4 and anti-cd8 monoclonal antibodies, respectively, and then infected with a. cantonensis. there were significantly more and less worms recovered in the mice depleted o ... | 1996 | 8960217 |
| cytokine responses in mice infected with angiostrongylus cantonensis. | for determination of the kinetics of cytokine production and its possible role in host resistance to angiostrongylus cantonensis in the mouse, th1 [interleukin 2 (il-2) and interferon gamma (ifn-gamma] and th2 (il-5 and il-4) cytokine production in the cerebrospinal fluid (csf), sera, and culture supernatants of spleen cells (sc) or cervical lymph-node cells (clnc) of infected balb/c and c57bl/6 mice was assessed by a sandwich enzyme-linked immunosorbent assay (elisa). il-5 and il-4 were detecte ... | 1997 | 9000226 |
| the detection and occurrence of circulating antigens of trichinella spiralis during worm development. | four enzyme-based immunoassays were compared in detecting circulating antigens (ca) of trichinella spiralis, i.e. microfluorescence, dissociated enhanced lanthanide fluoroimmunoassay (delfia), enhanced chemiluminescence and enzyme-linked immunosorbent assay (elisa). parameters which could affect the sensitivity and specificity of the assays were evaluated. different combinations of polyclonal antibody (pa) and five monoclonal antibodies (mabs) against the excretory/secretory antigens of the nema ... | 2001 | 11206114 |
| studies on cryopreservation of third-stage larvae of parastrongylus cantonensis. | attempts have been made to increase the survival rate of third-stage larvae of parastrongylus cantonensis during cryopreservation. parasites were obtained from experimentally infected snails, biomphalaria glabrata. the maximum non-toxic concentrations of cryoprotectants dimethyl sulphoxide (dmso) and glycerol were determined as 10% v/v in nctc 109 medium. different pre-cooling times and serum additives were assayed to determine their effects on the viability of larvae. larvae pre-cooled at -20 d ... | 1993 | 8509619 |
| in vitro cultivation of the third and fourth stage larvae of angiostrongylus cantonensis. | the third and fourth stage larvae of angiostrongylus cantonensis were cultured in various media. when the third stage larvae were cultured in rpmi 1640 supplemented with 20% fetal calf serum for four weeks, about 30% developed to the late third stage. on the other hand, when the fourth stage larvae recovered from rat brains were cultured in waymouth's chemically defined medium (mb 752/1) for one week, the worms grew rapidly and 74% developed into young adults. the mean body length of the worms i ... | 1993 | 8513022 |
| current views on geographic distribution and modes of infection of neurohelminthic diseases. | neurohelminthiases are more prevalent in geographic areas where environmental factors and poor sanitary conditions favor the parasitism between man and animals. in recent years, population shifts and rapid transport have facilitated the spread of certain helminthic diseases from endemic to non-endemic areas. although many helminthic parasites are known to cause various human diseases afflicting many millions of people in the world, neurohelminthiases are often not diagnosed because they have bee ... | 1997 | 9073023 |
| detection of circulating antigens of parastrongylus cantonensis in human sera by sandwich elisa with specific monoclonal antibody. | a specific monoclonal antibody (aw-3c2) as revealed by elisa was produced against the adult worm antigens of parastrongylus cantonensis and used in a sandwich elisa for the detection of circulating antigens in the sera of parastrongyliasis patients and those with other parasitic diseases. a total of 60 sera was used in this study. of these, 10 each were from patients with parastrongyliasis, cysticercosis, filariasis, gnathostomiasis, malaria and toxocariasis. the control group consisted of 53 se ... | 1995 | 9139382 |
| identification of angiostrongylus cantonensis in infected rats with a coagglutination assay. | the presence of angiostrongylus cantonensis excretory secretory (es) products was detected in the cerebrospinal fluid (csf) of infected rats using a coagglutination assay. there was clear agglutination in 100% of csf samples tested of the rats infected with third-stage larvae of a. cantonensis and neither of the 20 non-infected rats produced agglutination. the assay detected 250 ng/ml or more of es products. this assay is simple, easy to perform with minimum training and requires no equipment. | 1995 | 9139383 |
| influence of pf1022a on the motility of angiostrongylus cantonensis in vitro. | our previous in vivo studies on angiostrongyliasis showed that pf1022a had stronger killing effects against female adults than against males. no killing effects were observed against young adult worms in the central nervous system. to characterize the former in vivo action of pf1022a, in vitro effects of pf1022a on the motility of angiostrongylus cantonensis were studied directly. few differences in the efficacy were observed between male and female worms, but dose- and time-dependent inhibition ... | 1997 | 9211510 |
| humoral immune responses in mice infected with gamma-irradiated third-stage larvae of angiostrongylus cantonensis. | humoral immune responses in c57bl/6 strain mice infected with 1.0 kgy gamma-irradiated third-stage larvae (l3) and with non-gamma-irradiated l3 of angiostrongylus cantonensis were assessed in this study. the young-adult worm (l5) antigen-specific antibodies in sera of both groups of mice elevated gradually and reached a peak in the third week after infection. the igm antibodies of mice 1-week after infection with gamma-irradiated l3 and with non-gamma-irradiated l3 recognized several l5 antigens ... | 1997 | 9226968 |
| [angiostrongylosis in infants in reunion and mayotte. apropos of 3 cases of eosinophilic meningitis including 1 fatal radiculo-myeloencephalitis with hydrocephalus]. | eosinophilic meningitis caused by angiostrongylus cantonensis is widespread in southeast asia and pacific islands. adults develop a transient meningitis with a benign course but severe or fatal disease may occur in pediatric patients. | 1997 | 9230991 |
| the role of cd4+ and cd8+ t-cells in host morbidity and innate resistance to angiostrongylus cantonensis in the mouse. | strain-dependent differences in host morbidity and mortality due to angiostrongylus cantonensis infection have been established between c57bl/6 and balb/c mice; c57bl/6 mice show rapid worm killing with low morbidity, whereas balb/c mice indicate slow worm killing with high morbidity and mortality. to determine the possible roles of cd4+ and cd8+ t-cells in host morbidity and innate resistance to a. cantonensis infection we treated c57bl/6 and balb/c mice with anti-cd4 or anti-cd8 monoclonal ant ... | 1998 | 9493206 |
| [angiostrongylus in the infant at reunion and mayotte. apropos of 3 cases of eosinophilic meningitis including 1 fatal radiculomyeloencephalitis with hydrocephalus]. | background: eosinophilic meningitis caused by angiostrongylus cantonensis is widespread in southeast asia and pacific islands. adults develop a transient meningitis with a benign course but severe or fatal disease may occur in pediatric patients. case report 1: a 11 months old boy living in mayotte island was hospitalized some days after fever and skin rash with seizure status, coma, flaccid quadriplegia, absence of deep tendon reflexes, urinary retention and anal incontinence. eosinophilia was ... | 1997 | 9507763 |
| detection of circulating antigens of parastrongylus cantonensis in human sera by dot-blot elisa and sandwich elisa using monoclonal antibody. | a dot-blot elisa was compared with a previously performed sandwich elisa for the detection of parastrongylus cantonensis antigens in sera from patients. using the same monoclonal antibody and the same sera, 6 of 10 sera (60%) from parastronglyiasis patients were positive in dot-blot elisa, whereas with sandwich elisa, 5 of the same patient sera (50%) were positive. the specificity in both assays was 100% using 50 sera from patients with other parasitic diseases; of these, 10 each were from patie ... | 1997 | 9561620 |
| [a case of eosinophilic meningoencephalitis caused by angiostrongylus cantonensis with unique brain mri findings]. | a 17-year-old japanese girl was admitted to our hospital because of meningeal irritation, hyperesthesia of extremities, and disturbance of consciousness after having traveled to okinawa in february, 1996. examination on admission revealed pleocytosis of csf with many eosinophils (65%) and increased eosinophils (25%) in the peripheral blood. the history and clinical symptoms were suggestive of a parasitic infection. we diagnosed the patient as having eosinophilic meningoencephalitis caused by ang ... | 1998 | 9597905 |
| detection of circulating antigens of parastrongylus cantonensis in human sera by sandwich elisa with specific monoclonal antibody. | a specific monoclonal antibody (aw-3c2) as revealed by elisa was produced against the adult worm antigens of parastrongylus cantonensis and used in a sandwich elisa for the detection of circulating antigens in the sera of parastrongyliasis patients and those with other parasitic diseases. a total of 60 sera was used in this study. of these, 10 each were from patients with parastrongyliasis filariasis, gnathostomiasis, malaria and toxocariasis. the control group consisted of 53 serum samples from ... | 1997 | 9656365 |