PMID(sorted ascending)
taenia crassiceps: protein synthesis in larvae. 197714842
translation of taenia crassiceps mrna in cell-free heterologous systems.1. mrna isolated from larval taenia crassiceps directs efficiently the synthesis of proteins in cell-free heterologous systems. 2. part of the newly synthesized proteins in a reticulocyte system are precipitable by a rabbit antiserum against t. crassiceps proteins. 3. analysis of the antiserum-protein dissociated complex by sodium dodecyl sulfate polyacrylamide gel electrophoresis indicates that most of the proteins synthesized are of low molecular weight (13,000-22,000) although a protein of mo ...1978318332
aspects of the humoral response to laboratory white mice infected with the metacestodes of taenia crassiceps.two strains of laboratory white mice, cflp and laca, were infected with the metacestodes of taenia crassiceps. the serum from each infected mouse was tested for antibodies on double-diffusion gel plates and the number of antigen-antibody precipitin lines formed related (a) to the duration of the infection and (b) to the volume of metacestodes. there was a significant increase in the number of antigen-antibody precipitins with regard to the time infected but not to the volume of metacestodes. the ...1977407275
common host antigens in laboratory rats infected with the metacestodes of taenia crassiceps.laboratory rats were infected by intra-peritoneal injection with the metacestodes of taenia crassiceps. a soluble extract was prepared from the metacestodes removed from the peritoneal cavity of the rats. double-diffusion, immuno-electrophoresis and fluorescent labelled antibody staining techniques were used. the extract tested against rabbit anti-normal rat serum was found to contain an antigen common to both the host and the parasite.1977413855
a single oral treatment with mebendazole for the control of taenia crassiceps larval infections in rats. 1979447446
taenia crassiceps: effect of normal and immune serum on metacestodes in vitro. 1979456464
septate-like junctions between cells of the immune system in vivo.septate-like junctions between lymphocytes, lymphocytes and macrophages, and macrophages were observed in cellular capsules surrounding larvae of the tapeworm taenia crassiceps after intraperitoneal inoculation into immunized mice. the morphology of the junctions found in vivo is similar to that reported for septate-like junctions between cells of the immune system in vitro. these findings support the possibility that septate-like junctions may be involved in functional interactions between cell ...1979476838
the uptake of bilirubin by the metacestodes of taenia crassiceps. 1979479542
ultrastructural aspects of the host cellular immune response to taenia crassiceps metacestodes. 1979489239
some intestinal parasites of arctic fox, banks island, n. w. t.small intestinal parasitology of 50 trapped arctic fox taken on banks island, the northwest territories, showed a prevalence of taenia crassiceps (78%), toxascaris leonina (60%), echinococcus multilocularis (2%) and coccidia (2%). attention is drawn to the absence of toxocara sp. and of uncinaria sp.1979497890
taenia crassiceps in the rat: differences in susceptibility to infection and development of immunocompetence in relation to age and host strain. 1979500282
taenia crassiceps in the rat: transfer of immunity and immunocompetence with lymph node cells. 1979500283
kinetics of primary and secondary infections with taenia crassiceps metacestodes (zeder, 1800) rudolphi, 1810 (cestoda: cyclophyllidea). 1978631978
ultrastructural aspects of early immune damage to taenia crassiceps metacestodes. 1978631979
parasites of red foxes in new brunswick and nova scotia.sixty-one red foxes from new brunswick and nova scotia were examined for helminths. alaria americana, a. arisaemoides, a. mustelae, cryptocotyle lingua, echinostoma revolution and metorchis conjunctus, capillaria aerophila, crenosoma vulpis, toxocara canis, uncinaria stenocephala and taenia crassiceps were found. approximately 67% of the foxes examined were clinically affected with sarcoptes scabiei mange.1978691132
environmental temperature and the growth of taenia crassiceps cysticerci in mice.mice kept a low (5 +/- 1 degrees c) and high (35 +/- 1 degrees c) temperature harboured significantly less taenia crassiceps cysticerci than controls kept at 21 +/- 1 degrees c. this effect was more pronounced in heat-stressed than in cold-stressed animals and more in males than in females.1978720507
immunodepression in taenia crassiceps infection: restoration of the in vitro response to sheep erythrocytes by activated peritoneal cells.the in vitro response to sheep erythrocytes of mesenteric lymph node cells from mice infected with the larval cestode taenia crassiceps is significantly depressed and can be restored to control levels by addition of activated peritoneal cells depleted of functional t or b lymphocytes. adherent mesenteric lymph node cells from infected mice are unable to reconstitute the in vitro response to sheep erythrocytes of normal nonadherent cells. the responses of mesenteric lymph node cells from infected ...1978730359
studies on the in vitro culture of taenia crassiceps. 1976770356
depression of the immune response to sheep erythrocytes in mice infected with taenia crassiceps larvae.intraperitoneal infection of mice with larvae of the cestode parasite taenia crassiceps results in depression of both primary and secondary antibody responses to sheep erythrocytes in vivo. the depression is not associated with a shift in kinetics of the response. both immunoglobulin m (igm) and igg responses are depressed, but igg is depressed more than igm in the secondary response. secondary in vitro sheep erythrocyte responses are consistently depressed in both spleen and mesenteric lymph no ...1976786885
permeability studies on taeniid metacestodes: ii. antibody-mediated effects on membrane permeability in larvae of taenia taeniaeformis and taenia crassiceps.incubation in immune rat serum (irs) was shown to increase the rate of absorption of 125i rnase-a but not 125i bsa by larvae of taenia taeniaeformis and t. crassiceps. this effect required a heat labile factor in serum, and partial activity could be restored in heat-treated irs by adding normal rat serum (nrs) as a source of complement. in addition, the effectiveness of irs in altering permeability was shown to be dependent on the concentration of functional complement. both live and dead larvae ...1977859087
freeze-fracture study of the tegument of larval taenia crassiceps.the tegument of taenia crassiceps cysticerus is composed of 2 layers, an outer microthrix border and an underlying vesicular syncytium. each microthrix is a long slender structure that has 2 portions, a thick proximal portion and a thinner distal portion. the inner core of each microthrix contains a cylinder of microfilaments enclosing a central bundle of microfilaments. there are numerous particles on both the protoplasmic and extracellular fracture faces of the proximal portion of the microthr ...1977870670
efficacy of a new cestocide, praziquantel, against larval mesocestoides corti and taenia crassiceps in mice. 1977915635
intraperitoneal passage of taenia crassiceps in rats. 1976978374
gonadectomy and growth of taenia crassiceps (cestoda) cysticerci in mice.gonadectomy of swr of both sexes significantly reduced the number of cysticerci of taenia crassiceps, 60 days post infection. there was a significant decrease in the total number of larvae and the number of nonbudding individuals, corresponding with increased number of budding larvae. this indicates that the asexual multiplication of cysticerci in populations from gonadectomized mice was inhibited.19761021439
cytochemical characterization of tegument membrane-associated carbohydrates in taenia crassiceps larvae.the tegument of larval taenia crassiceps possesses a surface coat rich in both neutral and acidic carbohydrates. neutral glycans were detected in golgi vesicles of the tegument perikarya, vesicles of the distal tegument, and on the surface of the plasma membrane. autoradiographs indicated the tegument perikarya as major sites of 3h-galactose incorporation into acid-insoluble macromolecules. the labeled material is subsequently translocated to more superficial regions of the tegument, then concen ...19751165550
the growth of the metacestodes of taenia crassiceps in white mice.the effect of the sex of the intermediate host on the growth and development of the metacestodes of taenia crassiceps has been investigated. three different strains of mice were used, the c r s, l a c a and c f l p strains and two strains of metacestode, the toi and the e r s strains. the results show that matacestodes of t. crassiceps grow and multiply more rapidly in female than in male mice, although both sexes are equally susceptible to the infection. the origin of the parasite, i.e., from a ...19751206219
effect of parenterally injected benzimidazole compounds on echinococcus multilocularis and taenia crassiceps metacestodes in laboratory mice infected with metacestodes of taenia crassiceps, the following compounds were at least partially effective when injected intraperitoneally at the dosage indicated: cambendazole (500 mg/kg), mebendazole (6.25 mg/kg), oxibendazole (500 mg/kg), 5-benzamido-2(4-thiazolyl)benzimidazole (500 mg/kg), 2-carboethoxyamino benzimidazole (125 mg/kg), and 2-carbomethoxyamino benzimidazole (500 mg/kg). the following were inactive at the dosage indicated: parbendazole (500 mg/kg), thiabendazole (1,000 ...19751242396
the rat (rattus norvegicus) as a laboratory host for the metacestodes of taenia crassiceps. 19761255372
immune response to parasitic infection in mice without seminal vesicles.a protracted depression of anti-parasitic antibody and dth responses were observed in balb/c mice after surgical extirpation of seminal vesicles and ulterior infection with taenia crassiceps cysts. inclusion of male seminal accessory glands into the network of immunogonadal interactions was proposed.19921308806
comparative serological reactivity of taenia crassiceps, taenia solium and taenia saginata metacestode neutral glycolipids to infection serum from taenia crassiceps-infected mice.a comparative survey was undertaken of the neutral fraction glycolipids from the metacestodes of 3 taeniid species, taenia crassiceps, taenia solium and taenia saginata, to determine their chemical and serological staining patterns on separation by thin-layer chromatography. the orcinol-positive patterns of t. solium and t. saginata metacestodes exhibited a closer superficial resemblance to each other than to t. crassiceps or t. saginata adults. a comparison of component migration properties aga ...19921380126
[the helminth fauna of red foxes (vulpes vulpes linnaeus 1758) in north hesse and east westphalia. 1. cestodes].between november 1989 and june 1990 a total number of 397 foxes were examined for the presence of cestodes. the animals came from the districts of arnsberg, detmold and kassel. in 16.4% of the foxes infections with echinococcus multilocularis were found, in 28.5% taenia crassiceps, in 14.4% taenia polyacantha, in 4.3% mesocestoides spp., in 3.3% multiceps multiceps, in 2.5% hydatigera taeniaeformis, in 0.8% taenia hydatigena and in 0.3% taenia martis. infections with echinococcus multilocularis ...19921396164
skin disorders of the laboratory woodchuck (marmota monax): a retrospective study of 113 cases (1980-1990).an 11-year retrospective study was conducted on the dermatoses occurring in 113 woodchucks from a colony at the college of veterinary medicine at cornell university. bacterial dermatitis was the most common dermatologic disorder, accounting for 70.2% of the cases. the highest incidence of bacterial dermatitis occurred in september/october prior to hibernation and in february/march during the breeding season. other dermatoses observed during the study period included taenia crassiceps infection, ...19921424634
glycosphingolipids in cestodes. chemical structures of ceramide monosaccharide, disaccharide, trisaccharide and tetrasaccharide from metacestodes of the fox tapeworm, taenia crassiceps (cestoda: cyclophyllidea).the presence of glycosphingolipids in the metacestodes of the fox tapeworm, taenia crassiceps, has been established. the normal-phase tlc pattern of the neutral-fraction glycolipids revealed groups of bands corresponding to homologous components of increasing sugar chain length. the three simplest glycolipid components have been isolated and their chemical constitution determined as being of the neogala series: gal beta 1cer, gal beta 6gal beta 1cer and gal beta 6gal beta 6gal beta 1cer. the cer ...19921499551
[taenia crassiceps in the anterior chamber of the human eye. a case report].an otherwise healthy 15-year-old girl developed an iridocyclitis in her right eye. a contractable living parasite measuring two millimeter could be detected in the anterior chamber, the other parts of the eye remained uninvolved. the patient had close contact with the young dog of the family. by using a viscoelastic substance the parasite could be removed alive without any complications. the tapeworm was found to be too young for having developed the characteristic scolex. western-immunoblotting ...19921513125
immunological mediation of gonadal effects on experimental murine cysticercosis caused by taenia crassiceps metacestodes.female balb/c mice are naturally more susceptible than males to intraperitoneal experimental infection with taenia crassiceps metacestodes. gonadectomy tends to equalize susceptibility between sexes by reducing in half the mean individual intensity of females and by tripling that of males. the effect of gonadectomy is seen only in mice with intact immune systems but not in irradiated mice. purified sex hormones (17-beta estradiol, testosterone, and progesterone) do not affect cysticercus reprodu ...19921597791
taenia crassiceps surface immunoglobulins: parasite- or host-derived?in common with other taeniid cestodes, host or host-like proteins, especially immunoglobulins, occur on the surface and in the cyst fluid of taenia crassiceps metacestodes. here, several approaches have been used to determine the origin of the immunoglobulins present on the tegument. indirect ifat showed that igg was almost totally lost from the surface of bladders after 6 days culture in vitro. there was a rapid reacquisition of immunoglobulins following incubation of the cultured metacestodes ...19901700357
[taenia crassiceps infection in aids].a 33-year-old patient with aids, and a history of episodes of pneumocystis carinii pneumonia and cerebral toxoplasmosis, developed a subcutaneous paravertebral infiltrate, which at first resembled a haematoma. over a period of several weeks, the lesion spread to cover almost the entire back. initially, numerous investigations failed to reveal the aetiology. his general condition worsened progressively, and intermittent bleeding into the soft tissue of the back occurred, requiring transfusion. th ...19921733697
a recombinant immunodiagnostic antigen for bovine cysticercosis.the 70% ammonium sulfate-soluble fraction of the cyst fluid of taenia hydatigena (designated thfas) was previously shown to have potential as an immunodiagnostic reagent for bovine cysticercosis. western blot analysis indicated that the specific reactivity with antibodies in sera of t. saginata-infected cattle was associated with a 10 kda component. rabbit antiserum to thfas identified a homologous antigenic protein from the cestode taenia crassiceps. consequently, a cdna expression library was ...19911822902
vaccine effect of intact metacestodes of taenia crassiceps against t. taeniaeformis infection in rats.wistar rats inoculated intraperitoneally with 10 viable metacestodes of taenia crassiceps without adjuvant once on day 0 showed strong resistance to challenge with 200 eggs of t. taeniaeformis on day 30. when rats were killed one month after challenge, there were 80.4% and 46.1% reductions in the number of cystic and total metacestodes of t. taeniaeformis in the liver, respectively. when five rats were killed 16 months after challenge, they showed almost complete immunity against the challenge, ...19911830461
immunological recognition of larval taenia crassiceps glycolipids by sera from parasite-infected mice.the isolation and purification of a neutral glycolipid fraction from taenia crassiceps metacestodes (kbs strain), harvested from both male and female nmri mice at 70-80 days following intraperitoneal infection, revealed 24 thin-layer chromatography-designated glycolipid bands. the glycolipids were defined as ceramide mono- (n = 3), di- (n = 3), tri- (n = 4), tetra- (n = 5), and greater than tetrasaccharides (n = 9) according to their running properties as defined by thin-layer chromatography aga ...19911891452
murine taenia crassiceps cysticercosis: h-2 complex and sex influence on susceptibility.several inbred strains of mice were infected by intraperitoneal injection of ten taenia crassiceps cysticerci per mouse. genes linked with the major histocompatibility complex (h-2) were found to influence parasite growth greatly, as demonstrated by the different parasite loads of h-2 congenic mice with balb background: balb/c (h-2d) mice were the most susceptible, whereas balb/k (h-2k) and balb/b (h-2b) animals were comparatively resistant. non-h-2 genes had no significant effect on susceptibil ...19912047372
the ecology of echinococcus multilocularis (cestoda: taeniidae) on st. lawrence island, alaska. ii. helminth populations in the definitive host.the helminths of 1,579 arctic foxes from st. lawrence island were investigated by standard methods. the foxes, obtained mainly during the winter from fur trappers, harbored 22 species of helminths. four of those were trematodes, viz., maritrema afanassjewi belopol'skaia, 1952, orthosplanchnus pygmaeus iurakhno, 1967, plagiorchis elegans (rudolphi, 1802) and alaria marcianae (larue, 1917), each of which occurred in a single host. two species of cestodes, diphyllobothrium dendriticum (nitzsch, 182 ...19902080830
differential diagnosis of taenia saginata and taenia solium with dna probes.a size selected genomic dna library was constructed using dna extracted from taenia saginata. the dna was digested using the restriction enzyme ecor1 under star conditions and the 2-4 kbase fraction, selected following sucrose density-gradient separation, was cloned in the bacteriophage lambda gt 10. a panel of cestode dnas including taenia saginata, taenia solium, taenia taeniaeformis, taenia crassiceps, echinococcus granulosus and dnas of bovine, porcine and human origin were used in conjuncti ...19902141926
growth of a japanese isolate of taenia crassiceps in intermediate and definitive hosts.higher infection rates were observed in gerbils and voles than in icr mice after oral inoculation with eggs of a japanese isolate of taenia crassiceps. asexual reproduction of t. crassiceps cysticerci was observed in all gerbils and voles infected i.p. with the cysticerci. however, icr mice and wistar rats were not suitable for the asexual proliferation of t. crassiceps. the hooks of cysticerci from mice were smaller than those from gerbils. in experimentally infected puppies, parasite developme ...19902186408
establishment, development and fecundity of taenia crassiceps in the intestine of prednisolone-treated mongolian gerbils and inbred mice.worm establishment, development and fecundity of taenia crassiceps in the intestine of prednisolone (ptba)-treated, 15- and 4-week-old mongolian gerbils and 9-week-old inbred mice of 4 strains (akr/j, balb/can, b10d2/osn and c57bl/ksj) were investigated following oral administration of metacestodes. gerbils were divided into 5 groups of 4 animals each according to the host age and commencement day of ptba-treatment (day -13, -7 or 0 relative to infection). worm recovery from the intestine on day ...19902230031
molecular characterization of the surface and cyst fluid components of taenia crassiceps.information relating to the characterization of cestode surface macromolecules is limited. this is especially the case with taenia crassiceps, a well-recognized model for the study of larval cestodiasis. here, the protein and glycoprotein composition of the tegumental surface and cyst fluid of the metacestode have been investigated using radio-isotope labelling, immunoprecipitation, sds-page and lectin affinity chromatography. a restricted number of surface proteins was labelled with the 125i/io ...19902235068
[epidemiology of alveolar echinococcosis in france. 1. intestinal helminths in the red fox (vulpes vulpes l.) from haute-savoie].in the course of an epidemiological survey concerning the alveolar echinococcosis and its causative agent, echinococcus multilocularis, the autopsies of 150 wild red foxes captured in the department of the haute-savoie between december 1983 and august 1988 disclosed 139 cases of intestinal helminthiasis with cestodes and nematodes; no trematode was found. multiple infections were frequent. the cestoda recorded consist of the following species: taenia crassiceps: 44 cases (29%); echinococcus mult ...19902344133
development and sexual maturation of taenia crassiceps (cestoda) in the golden hamster.the development of cysticerci of taenia crassiceps to mature tapeworms in the intestinal tract of cortisone-treated and untreated golden hamsters is described. the development of the worms in untreated hamsters is as follows. maturation and branching of the uterus and the presence of ova in the uterus were observed on day 15 postinfection (pi). by day 21 pi, fertilization had taken place, as evidenced by the presence of sperm in the seminal receptacle. on day 28 pi, shelled eggs were observed in ...19902352070
purification of an antigen from the taenia crassiceps metacestode vesicular fluid highly sensitive in detecting igg-antibodies (elisa) in calves with experimental cysticercosis.this study reports on the purification of an antigen predominant within the vesicular fluid (vf) of t. crassiceps metacestodes and shown to share identity with the major vesicular fluid protein of the t. saginata larval stage. purification was achieved by gel filtration of the vf on sephacryl s-300 superfine, followed by ion exchange hplc. the antigen represents a single polypeptide chain (mr appr. 37,000) with carbohydrate moieties without affinity to cona. isoelectric focusing of the electroph ...19902385982
immunodiagnosis of human cysticercosis in cerebrospinal fluid. antigens from murine taenia crassiceps cysticerci effectively substitute those from porcine taenia solium.tapeworm antigens from taenia crassiceps performed as well as those antigens from taenia solium in an enzyme-linked immunosorbent assay for the detection of cysticercus antibodies in 96 cerebrospinal fluid samples from patients with neurocysticercosis and in 96 csf samples from patients with other varied neurological ailments. thus, this manageable murine model of experimental cysticercosis solved the problem of antigen supply for clinical and epidemiological applications, and it provided an imm ...19902390007
inhibition of in vitro and in vivo mast cell degranulation by taenia crassiceps metacestodes in vitro incubation vitro released products of t. crassiceps metacestodes (tcip) harvested from the peritoneal cavity of nmri mice were tested for inhibitory effects on the in vitro degranulation of peritoneal mast cells (mcs) of normal mice (nmri) and rats (wistar) and on the in vivo degranulation of rat (wistar) skin mcs (pca-assay). in vitro degranulation was elicited chemically (compound 48/80, polymyxin b or the bee venom peptide, mellitin). in vivo degranulation was triggered immunologically (anaphylactic ...19892479392
influence of thymic preparations on the result of experimental infection with taenia crassiceps (zeder, 1800) in icr mice.thymalin (thymarin) and t-activin--thymic preparations of polypeptidic character--were used for influencing the parasitic infection in a model system mouse--taenia crassiceps. a single subcutaneous application of 100 micrograms of thymalin per mouse at the day of infection resulted in a decrease (by 54.9%) in the number of cysticerci in peritoneal cavity of experimental mice compared with the controls. administration of thymalin with t. crassiceps larval homogenate at various intervals before an ...19892488049
experimental cysticercosis by taenia crassiceps in mice: factors involved in susceptibility. 19892488991
immunoelectrophoretic analyses of antigens shared by the vesicular fluid and cyst wall of taenia crassiceps and taenia saginata this study, the antigenic mosaic of the vesicular fluid (vf) and hydrosoluble cyst-wall extract (cwe) of t. crassiceps (tc; harvested from mice) and t. saginata (ts) metacestodes was analyzed by combined precipitation maps developed in single and bidimensional immunoelectrophoresis against the respective rabbit antiserum. host-serum proteins demonstrated by immunodiffusion within tcvf (albumin, transferrin, igg, and another five noncharacterized proteins), tccwe (albumin, igg, and six additio ...19892505250
taenia crassiceps metacestode vesicular fluid antigens shared with the taenia solium larval stage and reactive with serum antibodies from patients with neurocysticercosis.after removal of host (mouse) serum proteins (albumin, transferrin, igg and another five unidentified proteins) by immunoaffinity chromatography, the vesicular fluid of t. crassiceps metacestodes (tcvf) was immunoelectrophoretically examined for antigens recognized by rabbit antiserum to aqueous crude extract of t. solium cysticerci. based on a precipitate pattern developed in electroimmunodiffusion, nine cross-reactive antigens could be demonstrated. in the elisa, tcvf was shown to be a potent ...19892510753
the ige and igg subclass responses of mice to four helminth investigate whether the formation of ige is linked in vivo to an igg subclass, mice were infected with four helminth parasites, nippostrongylus brasiliensis (nbr), mesocestoides corti, taenia crassiceps and trichinella spiralis, and the changes in the serum levels of the different ig isotypes as well as the antibody response to m. corti and t. crassiceps antigen extracts were determined by radioimmunoassays. all four parasites induced a concomitant increase of the ige and igg1 serum levels an ...19892522026
deleterious effect of prednisolone on the attachment of taenia crassiceps cysticerci to the intestine of gerbils. 19892607737
larvae of taenia crassiceps (cestoda): host specificity and localisation. 19892694169
purification and properties of cytoplasmic malate dehydrogenase from taenia crassiceps (zeder, 1800) cysticerci.malate dehydrogenase (l-malate: nad oxidoreductase, ec from the cytoplasm of taenia crassiceps cysticerci was purified and the basic kinetic parameters of this enzyme were determined. the ph optimum range of enzyme reaction was found to be very wide: 8.8-11.0 for malate oxidation and 6.0-8.5 for oxaloacetate reduction. km values for oxaloacetate, malate, nad, and nadh were 7.8.10(-5) m, 1.4.10(-4) m, 1.2.10(-4) m, and 6.10(-5) m, respectively. malate dehydrogenase activity was inhibite ...19892767551
effect of t-activin on the course of experimental infection with taenia crassiceps (zeder, 1800) in mice.t-activin--an immunomodulating preparation of polypeptidic character prepared from calf thymus--was used for influencing the course of infection in a model system mouse-taenia crassiceps. a single s.c. application of 100 micrograms of t-activin at various intervals before and after infection resulted in a marked decrease in the number of cysticerci in peritoneal cavities of experimental mice (by 47.1-93.6%) compared to the controls. after s.c. application of t-activin and i.p. injection of antig ...19892767556
synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives.a series of 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-alpha][2] benzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro taenia crassiceps screen. many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b- octahydropyrazino[2,1-alpha][2]benzazepine, epsiprantel (ban) (22), was selected for further development. the structure-activity relationships are discussed.19892769679
taenia crassiceps: experimental model of intraocular experimental model of taenia crassiceps intraocular cysticercosis was developed in rabbits. the objectives of this study were to analyze the pathophysiology of this parasitic infection and to evaluate the humoral immune response. cysticerci, inoculated in the anterior chamber of the eye, were able to grow; no inflammatory changes in the eye or anticysticercus antibodies in serum or in aqueous humor were detected during the 12-day period. in contrast, rabbits that had previously been either in ...19892806459
deciphering western blots of tapeworm antigens (taenia solium, echinococcus granulosus, and taenia crassiceps) reacting with sera from neurocysticercosis and hydatid disease patients.complex antigen mixtures displayed in western blots may be immediately and quantitatively categorized with respect to specificity and immunogenicity by immunoplotting. this involves plotting the frequency with which each antigen band reacts with a set of immune sera against the frequency of the same band when reacted with another set of immune sera. immunoplotting has proven to be a powerful method of analyzing western blots of reactions between vesicular fluids from the metacestodes of taenia s ...19892929850
[evaluation of the results of intradermal tests in spontaneous cysticercosis in cattle].the diagnostic value of intradermal tests was verified on 126 bulls (out of this number 32 autopsically positive) subject to intravital diagnostics of bovine cysticercosis. as allergen were used homologous antigens from adult larvae of taenia saginata and heterologous antigens from larvae of taenia crassiceps, as well as hydatid fluid from echinococcus granulosis. with the antigen t. saginata the sensitivity reached 53.1% and specificity 90.4%, with the antigen t. crassiceps 53.1% and 80.9% and ...19863083557
[counterimmunoelectrophoresis in the serologic diagnosis of cysticercosis in cattle].over the years 1983 to 1984 two-hundred and sixty-five bulls were examined during mass occurrence of bovine cysticercosis in one farm; out of this number 67 animals (25.3%) were confirmed autopsically as infected with cysticercosis. counterimmunoelectrophoresis was used to examine the serum of slaughtered animals by help of two antigens--taenia saginata and taenia crassiceps. with t. saginata the sensitivity amounted to 44.8% and the specificity to 86.4%, with t. crassiceps to 28.3% and to 89.9% ...19863083565
chalone-like inhibition of dna synthesis in helminths.chalone-like inhibitory activity was found in extracts from tissues of taenia crassiceps cysticercus and tissues of adult ascaris suum. the inhibitory effects were partially species nonspecific: the extracts from t. crassiceps larvae inhibit both t. crassiceps and mesocestoides corti larvae dna synthesis. extracts from a. suum, however, inhibit only t. crassiceps. besides them, the inhibitory factor from mouse brain inhibits both t. crassiceps and m. corti dna synthesis. when the inhibitory fact ...19853159635
phosphoglycerides and derivatives in taenia crassiceps examined by 31p nmr spectroscopy.examination of the larval stage of the tapeworm, taenia crassiceps, by 31p nmr spectroscopy revealed the presence of a major phosphoglyceride component. however, using saturation transfer, no exchange between glycerophosphorylcholine and phosphoglyceride or any other nmr-detectable phosphorus metabolites was detected.19883357104
comparison of the in vitro translation capacity of taenia crassiceps metacestode mrna prepared by the phenol and cesium chloride rna of t. crassiceps metacestodes harvested from male and female nmri mice was prepared by both the phenol extraction technique and cesium chloride (cscl) gradient centrifugation. mrna was selected by oligo (dt)-cellulose affinity chromatography and used as the template for the in vitro translation of parasite polypeptides in a cell-free rabbit reticulocyte lysate. the template activity of the mrna obtained after cscl preparation was clearly higher, as shown by the amount of 35s-methionine ...19883413044
transhydrogenase activities in the mitochondria of taenia crassiceps (zeder, 1800) cysticerci.nadph/nad and nadh/nad transhydrogenase activities have been demonstrated in the mitochondrial fraction of taenia crassiceps cysticerci. these activities seem to result from the activities of two different enzyme systems. both transhydrogenase activities exhibited a high heat resistence and they were completely abolished only by the temperatures higher than 100 degrees c. the activity of nadh/nad transhydrogenase was rather high (116 protein), but it was found to exhibit a low af ...19883417198
levamisole--biological response modifier in taenia crassiceps--mouse experimental system.levamisole, a common anthelminthic preparation, was used for the modification of the immune response of mice to vaccination with soluble antigen from taenia crassiceps. the combination of antigen with levamisole significantly increased the immunogenic effect of the antigen. metacestodes survived in 16.7% after one dose and in 42.9% after two doses of levamisole. the percentage of resistance was 97.7% and 67.8%.19883417199
studies on the properties of malic enzyme and malate dehydrogenase from taenia crassiceps (zeder, 1800) has been studied what type (or types) of malic enzyme is present in the mitochondria of taenia crassiceps cysticerci. only nadp-dependent malic enzyme (ec was demonstrated. the method of isoelectric focusing was used for the detection of isoenzymes of malic enzyme and malate dehydrogenase in the cytoplasm and mitochondria of t. crassiceps cysticerci. the mitochondria contain 5 isoenzymes of malic enzyme and 5 isoenzymes of malate dehydrogenase. the cytoplasm contains 7 isoenzymes of ...19873428763
dependency of resistance of mice immunized against taenia crassiceps on the dose of soluble antigen.mice immunized with a single dose (1.25-40 micrograms/mouse) of soluble antigen from taenia crassiceps cysticerci developed a 62.9-85.0% resistance. maximum effect was achieved in the groups immunized with 40 micrograms and 20 micrograms of antigen. the dose of 5 micrograms induced the lowest number of successful infections (28.6%), but the mean number of surviving larvae was higher than in the above groups.19873428764
correlation of the results of ifat-dass and elisa tests in experimental cysticercosis of mice.the sera of mice experimentally infected with taenia crassiceps were tested for the occurrence of the antibodies by the enzyme-linked immunosorbent assay (elisa) and indirect immunofluorescence using defined antigen substrate spheres (ifat-dass). results of both tests were compared. from day 11 p.i. until the end of the experiment (day 108 p.i.) antibodies were detected by both tests. the maximal intensity of the elisa and ifat-dass reactions was observed between days 63 and 94 and days 14 and 4 ...19873556351
malic enzyme, malate dehydrogenase, fumarate reductase and succinate dehydrogenase in the larvae of taenia crassiceps (zeder, 1800).malate dehydrogenase, malic enzyme, succinate dehydrogenase, and fumarate reductase activities have been studied in the cytoplasm and mitochondria of taenia crassiceps larvae. the results show that these larvae contain enzymes for anaerobic acquisition of energy with terminal fumarate reductase, but some facts, as the high ratio of succinate dehydrogenase activity to fumarate reductase activity and the low proportion of fumarate reductase in the whole nadh oxidase activity in mitochondria, sugge ...19873596392
a case report of cysticercosis caused by cysticercus longicollis, a larval form of taenia crassiceps in a woodchuck (marmota monax).cysticercosis was found in one of 18 woodchucks imported from the united states and maintained in our laboratory for study of hepatitis and hepatocellular carcinoma. the lesions found in subcutaneous area, lungs and maxillary sinus were multiple cysts containing numerous cysticerci identified as cysticercus longicollis, a larval form of taenia crassiceps.19873609159
magnetic resonance imaging of parasitic tapeworm larvae taenia crassiceps cysticerci in the peritoneal cavity of mice.because of their long t2 relaxation time (400 ms), larvae of the tapeworm taenia crassiceps can be distinctly imaged in the mouse peritoneal cavity by nmr. an echo time of 400 ms sharply contrasted the parasites against the surrounding abdominal organs. a rapid, quantitative assay for parasite load can be obtained by recording the amplitude of a spin echo with no applied gradients at an echo time of 400-1000 ms. the t2 of the vesicular fluid of the human parasite taenia solium was also long (600 ...19873613952
characteristics of malic enzyme from the cysticerci of taenia crassiceps (zeder, 1800).kinetic parameters of partly purified malic enzymes (nadp+: l-malate oxidoreductase (decarboxylating) ec from the cytoplasm and mitochondria of taenia crassiceps cysticerci were compared. the cytoplasmic malic enzyme differed from the mitochondrial malic enzyme in the k'm for malate; other studied properties were identical. the chromatographies of both the cytoplasmic and mitochondrial enzymes were identical. they exhibited a hyperbolic dependence of the activity on malate concentratio ...19873666613
study of cytochromes from mitochondria of taenia crassiceps (zeder, 1800) cysticerci.cytochrome components of mitochondria from taenia crassiceps cysticerci were studied by difference spectrophotometry (at 22 degrees c). the following concentrations of cytochromes (expressed in nmol x mg-1 protein) were found: 0.132 (cytochrome b), 0.083 (cytochrome c), and 0.0856 (cytochrome aa3). the participation of aerobic processes in the general production of energy is discussed and the results are compared with literary data obtained in cytochrome studies of other parasitic worms.19863721356
experimental infection of high and low responder biozzi mice with taenia crassiceps (cestoda). 19863744664
anthelmintic activity of triclabendazole.triclabendazole was tested in vitro and in vivo against a range of helminths. although in vitro activity was found against hymenolepis diminuta (0.5 microgram/ml), fasciola hepatica (2.5 micrograms/ml), taenia crassiceps and schistosoma mansoni (50 micrograms/ml), in vivo activity was only found against f. hepatica, a single oral dose of 40 mg/kg killing 99% of adult flukes in the rat. this spectrum of activity suggests a mechanism of action unlike that of other benzimidazole anthelmintics.19863745874
suppression of taenia crassiceps during concurrent infections with mesocestoides corti in mice.parasite burden (by volume) was measured in female mice of three strains given single or concurrent infections of mesocestoides corti and taenia crassiceps. significant suppression of t. crassiceps volume was observed over a range of m. corti inocula and occurred irrespective of whether m. corti was introduced before or after infection with t. crassiceps. suppression of t. crassiceps volume was greatest with larger inocula of m. corti and with increased duration of m. corti infection. no signifi ...19863754325
study of the properties of alkaline phosphatase in taenia crassiceps (zeder, 1800) cysticerci.the properties of alkaline phosphatase present in taenia crassiceps cysticerci were studied. approximately a half of the total activity was free and the remaining part was bound to membranes. kinetic studies did not show any differences between the free and bound alkaline phosphatases. it was found that high substrate concentrations produced an inhibitory effect on the enzyme. this effect was much greater at lower ph. ph optimum changed with the concentration of the substrate.19863758872
contribution to the knowledge of aerobic processes in taenia crassiceps larvae (zeder, 1800).respiration of homogenates and isolated mitochondria of t. crassiceps larvae was measured. respiration (about 70%) could be inhibited by cyanide, indicating that an important part is played by classical respiratory chain. when succinate was used as substrate, relatively low respiratory rates were measured, mitochondria showing higher affinity to nadh. above a half of respiratory rate remained unchanged even at very low oxygen concentrations. fumarate exhibited inhibitory activity on respiration ...19863804084
[parasites present in foxes (vulpes vulpes) of the province of forli].in the period march 1983 - march 1984 a parasitological survey was carried out on 103 foxes killed in the forli province (italy). the parasites identified were: toxocara canis (45.6%); uncinaria stenocephala (14.6%); mesocestoides lineatus (9.7%); dipylidium caninum (2.9%); taenia crassiceps (2.9%); trichuris vulpis (2.9%). out of all the cestodes found in 7 animals the authors identified only genus taenia since their preservation conditions were not optimal. other 13 subjects contained many ces ...19853870647
changes in ascorbic acid content in various organs and serum of mice experimentally infected with taenia crassiceps (zeder, 1800) was demonstrated that helmith infection affects the ascorbic acid content in various tissues of experimental mice. the level of vitamin c in the mouse liver, kidneys, spleen and serum decreases after infection with t. crassiceps. maximum decrease in blood serum was observed on day 7 p.i. at the intensity of infection 15 and 30 cysticerci per mouse. there was a correlation between the intensity of infection and decrease in the ascorbic acid level in the spleen.19854007703
food intake and body weight changes in mice infected with metacestodes of taenia crassiceps.general nutritional effects on female cflp mice harbouring larval taenia crassiceps were investigated using groups of mice fed ad libitum on purified diets containing 2%, 4%, 8% and 16% (w/w) protein respectively. when uninfected and infected mice were compared over an experimental period of 20 weeks, it was established that a significantly higher proportion of uninfected mice survived the course of the experiment than infected mice. there was no evidence of the presence of the parasites having ...19854011315
proceedings: further studies on the effect of taenia crassiceps on rats and mice. 19744419379
treatment of the cystic stage of taenia crassiceps and echinococcus multilocularis in laboratory animals. 19744436750
growth and development of larval taenia crassiceps (cestoda). i. aneuploidy in the anomalous orf strain. 19724652612
growth and development of larval taenia crassiceps (cestoda)-ii. rna and dna synthesis in the orf and kbs strains determined by autoradiography. 19724661368
morphologic anomalies in scoleces of larval taenia crassiceps. 19734687485
taenia crassiceps: absorption of hexoses and partial characterization of na + -dependent glucose absorption by larvae. 19734691924
intraocular taenia crassiceps (cestoda). ii. the parasite. 19734717691
mechanisms and specificity of amino acid transport in taenia crassiceps larvae (cestoda). 19734741640
intraocular taenia crassiceps (cestoda). 19734772538
permeability and membrane transport in the larva of taenia crassiceps. 19734786832
taenia crassiceps: antigenic comparison of two larval strains. 19714997335
tapeworm larvae (taenia crassiceps) in woodchucks. 19725056190
growth and development of larval taenia crassiceps (cestoda). 3. the relationship between larval biomass and the uptake and incorporation of 14 c-leucine. 19725057037
some effects of sub-lethal x-irradiation on reproduction and development in two strains of larval taenia crassiceps. 19715156167
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