| mannosyl transferase activity in homogenates of adult schistosoma mansoni. | homogenates of adult schistosoma mansoni contain enzymes which are capable of transferring [14c]mannose from gdp[u-14c]mannose to a lipid acceptor which migrates as a single peak on a silica gel thin-layer plate. this lipid may belong to the class of polyprenol monophosphates which are intermediate elements in the glycosylation of nascent proteins. the schistosome mannosyl transferase activity is associated with membranous particles and is dependent on the presence of mn2+. however, other divale ... | 1978 | 756527 |
| [the "elisa" assay in the immunological diagnostic of s. mansoni (author's transl)]. | | 1978 | 757725 |
| carcinogenic potential of hycanthone in mice and hamsters. | hycanthone was administered to schistosoma mansoni-infected and non-infected syrian golden hamsters and swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose. no tumors attributable to treatment were observed in hamsters. in infected mice, the overall incidence of hepatomas and hepatocellular carcinomas increased from 3.4% in untreated mice to 10.6% in those treated with hycanthone. non-infected control mice developed 0.8% of these tumors compared ... | 1979 | 759380 |
| cross reactivity of schistosome antigens between schistosoma mansoni and japonicum. | fifty six patients with chronic schistosomiasis japonica were given skin tests with preparations made of schistosoma mansoni and schistosoma japonicum. there was a high, significant positive correlation between the results of both antigens. among 47 serum samples tested with indirect hemagglutination (iha) 27 had the antibody titer 1:16 or higher, which was diagnostically significant in combination with positive skin test results. the results indicate a definite cross reactivity of japonicum and ... | 1979 | 760262 |
| mouse antibody-dependent eosinophil and macrophage adherence and damage to schistosomula of schistosoma mansoni. | the effects of sera from s. mansoni-infected mice together with eosinophil- and macrophage-rich peritoneal exudate cells (pec) on the schistosomula were examined in vitro. adherence to and killing of the parasite by pec is mediated through a complement-independent opsonizing igg. destruction of schistosomula was assessed morphologically and by evaluating their infectivity to normal mice. by using ferritin-labeled anti-mouse immunoglobulin, the antibody was localized on the surface of the schisto ... | 1979 | 762428 |
| killing of schistosomula of schistosoma mansoni coated with antibody and/or complement by human leukocytes in vitro: requirement for complement in preferential killing by eosinophils. | | 1979 | 762435 |
| intermediate host specificity in schistosoma mansoni. | | 1976 | 767127 |
| schistosomiasis mansoni and japonicum in microtus montanus. | | 1976 | 768436 |
| clinical treatment of schistosomiasis mansoni with a new schistosomicidal agent: hycanthone or etrenol. | | 1976 | 772233 |
| the host antigen phenomenon in experimental murine schistosomiasis: the transfer of 3-week old schistosoma mansoni between two inbred strains of mice. | | 1976 | 776883 |
| the course of schistosoma mansoni infection in thymectomized rats. | inbred rats were thymectomized, irradiated, and reconstituted with t cell-free bone marrow cells. thymectomized-reconstituted (b rats) and control rats were infected with schistosoma mansoni cercariae and the number of worms recovered was determined at various times after infection. the extent of immunosuppression was assessed by two criteria: 1) response to an injection of sheep erythrocytes (plaque assay, hemagglutination, hemolysis); 2) response to schistosome antigens (passive hemagglutinati ... | 1976 | 778268 |
| [unusual distribution of fluorescent marking during schistosoma mansoni schistosomiasis (author's transl)]. | the sera of some patients suffering from intestinal bilharziasis determine, on frozen sections of adult s. mansoni, a labelling of the digestive tract disclosed by the fluorescent sera anti-igg and igm. this labelling appears early after the primary infestation and may remain isolated. it is found again later, among west indian patients of all ages infested by s. mansoni. its development is followed in the hamster and the mouse, experimentally infested. this labelling is also present in the anim ... | 1976 | 778761 |
| the use of serology by titering of fluorescent antibodies to evaluate levels of transmission of schistosomiasis in rhodesia. | the prevalence of schistosomiasis has been measured by parasitological examination and by fluorescent antibody titering in a number of communities in different parts of rhodesia. the samples were taken from areas of high, medium, and low transmission of the disease. a correlation was detected between the mean titer and prevalence of infection, particularly in the younger people (4-13 years old). it is suggested that fluorescent antibody titrating may be a useful epidemiological tool. | 1976 | 779501 |
| schistosomiasis in antiquity. | | 1976 | 781425 |
| schistosomiasis mansoni: a granulomatous disease of cell-mediated immune etiology. | | 1976 | 786125 |
| the eosinophil stimulation promoter test in murine and human trichinella spiralis infection. | a test for the lymphokine eosinophil stimulation promoter (esp) has been adapted to the study of trichinella spiralis infections in mice and has been used as an aid in the diagnosis of trichinosis in a patient. with use of soluble antigen extracted from t. spiralis larvae and peritoneal exudate cells rich in eosinophils obtained from mice with trichinosis of four weeks' duration, a dose-response curve was constructed and analyzed. the soluble larval antigens greatly enhanced the migration of eos ... | 1976 | 789785 |
| t-cell helper response to antigens of schistosoma mansoni in cba mice. | it is believed that a t-cell helper response against the schistosome surface is a necessary prerequisite for the development of protective immunity in schistosomiasis. accordingly, the carrier effect has been used to assay eleven antigenic preparations of schistosoma mansoni for their helper t-cell priming against surface components of the schistosomula. three weeks after i.v. injection of the preparation, cba mice were injected with schistosomula coated with trinitrophenol (tnp) and 4 days late ... | 1976 | 791552 |
| host complement in the schistosomal tegument. | | 1976 | 794513 |
| development of fluorescent antibodies directed against larval stages, eggs, and adults of schistosoma mansoni in mice harbouring unisexual or bisexual infections. | the development of antibodies corresponding to the different developmental phases of schistosoma mansoni was studied in mice subjected to experimental unisexual and bisexual infections. blood samples were taken at weekly intervals for up to 5 months and tested by indirect immunofluorescence against frozen sections of male and female worms (collected from animals with unisexual infections), of liver of infected hamsters (containing schistosome eggs) and of the hepatopancreas of infected snails (c ... | 1976 | 795117 |
| enzyme- and 125i-labeled anti-immunoglobulin assays in the immunodiagnosis of schistosomiasis. | an enzyme-linked immunosorbent assay (elisa), and radioimmunoassays using antigen bound to plastic tubes or microcrystalline particles, were adapted for the indirect serological measurement of anti-schistosome antibodies. these alkaline phosphatase and 125i-labeled anti-immunoglobulin techniques were found to be highly quantitative and adaptable. comparison showed them to be considerably more sensitive than the indirect hemagglutination and indirect fluorescent antibody techniques. using adult s ... | 1976 | 795311 |
| [two specific aspects of fluorescent labeling of schistosoma mansoni on frozen sections from trichinosis and bilharziasis]. | | 1976 | 797479 |
| [use of etrenol for the treatment of schistosomiasis (review of the literature)]. | | 1976 | 799235 |
| the physiobiology and pathogenesis of human schistosomiasis. | | 1975 | 799573 |
| behavioral and developmental physiology of schistosome larvae as related to their molluscan hosts. | | 1975 | 801112 |
| long-term efficacy of tubercidin against schistosomiasis japonica and mansoni in primates. | schistosomiasis japonica in capuchin msnkeys (cebus apella) and schistosomiasis mansoni in baboons (papio cyanocephalus and p. hamadryas) were completely arrested for 6 months in every infected primate receiving a single treatment with tubercidin (tu), administered after prior absorption into 20% of their red cells. it is very likely that a single treatment with tu sequestered in only 15% of the hosts' red cells would also be 100% effective for prolonged periods of time, but that with lower dose ... | 1975 | 804270 |
| spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni. | spontaneous diminution of granuloma formation around schistosome eggs in chronic schistosomiasis mansoni has been demonstrated previously. in the present study these findings were confirmed by injecting schistosome eggs into the pulmonary microvasculature and removing the lungs 8 days later from mice infected for 4, 8, 12, 16, and 20 weeks; the mean area of inflammation around the eggs was then measured. at 4 weeks a primary reaction was seen, by 8 weeks a massive secondary reaction occurred, bu ... | 1975 | 804513 |
| activity of known antischistosomal agents on early-developing forms of schistosoma mansoni. | sixteen compounds, including several series of antischistosomal agents, were tested in mice (subcutaneous, oral, and intramuscular routes), previously injected intraperitoneally with 175 plus or minus 25 schistosoma mansoni cercariae. most drugs were given in a 5-day regimen, first dose being administered 3 hr before cercarial inoculation. ten days after infection the animals were killed, the schistosomules collected from peritoneal washings, and counted under a dissecting microscopy (free organ ... | 1975 | 805229 |
| the inhibition of granuloma formation around schistosoma mansoni eggs. | the effect of protein, calorie, and vitamin deficiency states on the granulomatous response of mice to eggs of s mansoni injected into the microvasculature of the lungs was studied. moderate to severe protein and calorie deficiencies, as well as thiamine and vitamin c deficiencies, inhibited the host's granulomatous response to s mansoni eggs, which is a form of delayed-type hypersensitivity. the antivitamins neopyrithiamine hydrochloride and desoxypyridoxine hydrochloride were both highly effec ... | 1975 | 806231 |
| schistosoma mansoni: the role of the complement c3-activating system in the cercaricidal action of normal serum. | | 1975 | 807484 |
| calorie and protein malnutrition in chronic murine schistosomiasis mansoni: effect on the parasite and the host. | the effects of diets containing 8% and 4% protein and of 50% calorie-deficient diets on the host, the parasite, and the parameters of disease in chronic hepatosplenic schistosomiasis were studied in mice that were infected for 20 weeks with schistosoma mansoni. controls consisted of uninfected mice of the same size and age maintained on a balanced 20% protein diet. each of four corresponding dietary groups of infected and uninfected animals was fed on its assigned diet from the 20th to the 24th ... | 1975 | 808580 |
| [the role of specific ige antibodies in the immune adherence of normal macrophages to schistosomes of schistosoma mansoni]. | specific ige antibodies from immune rat serum were demonstrated to mediate the immune adherence of normal rat macrophages to schistosome mansoni schistosomules, which was followed by a cytototoc action. hence, a new positive role of ige antibodies in protective immunity is argued. | 1975 | 809179 |
| immunodiagnosis of human schistosomiasis using different immunoprecipitation techniques. | one hundred sera of individuals infected with schistosoma mansoni and/or s. haematobium were examined for the presence of specific anti schistosoma antibodies by means of different immunoprecipitation techniques: immunoelectrophoresis, immunodiffusion, immunoelectroosmophoresis (on two different supports), and electroimmunodiffusion. the immunoelectroosmophoresis proved to be superior to the other immunoprecipitation techniques, its main advantages being sensitivity, rapidity, and economic use o ... | 1975 | 810988 |
| [castration of the snail biomphilaria glabrata by the larvae of various guadeloupean trematoda]. | four species of trematoda accomplish their larval development in the snail biomphalaria glabrata. they determine the sterility of the mollusc in different ways and could be used in the biological control of schistosomiasis resulting from schistosoma mansoni. | 1975 | 811375 |
| treatment of chronic enteric fever with amoxicillin. | twelve patients with proven salmonella typhi or salmonella paratyphi a bacteriuria and recurrent bacteremia associated with schistosomiasis were treated for four weeks with amoxicillin (250 mg four times daily). seven of the 12 patients were seriously ill and febrile before treatment. they showed a dramatic response, and, within three to six days of initiation of amoxicillin therapy, they were afebrile and much improved clinically. amoxicillin was rapidly and highly concentrated in the urine of ... | 1975 | 811715 |
| dialyzable transfer factor. | dialyzable transfer factor, obtained from human peripheral blood leukocytes and first described by lawrence, is being used in attempts to rectify defects in the cellular immune systems of patients with basic immunodeficiencies, chronic infectious diseases, and neoplastic diseases. current knowledge of the chemical character of, assays for, and functional activities of transfer factor are briefly reviewed. an experimental animal model for dialyzable transfer factor involving the rhesus monkey (ma ... | 1975 | 812183 |
| [the role of the rat in the dynamics of endemic schistosomias in guadeloupe]. | in guadeloupe (french lesser antilles), because they are simultaneously infested with schistosoma mansoni, which causes the human intestinal schistosomiasis, and ribeiroia marini, a trematode which sterilizes the mollusk-host of the schistosoma, the rats (rattus rattus and rattus norvegicus) seem able to influence, at least locally, the infestation of the human population. | 1975 | 813876 |
| the immunology of schistosomiasis. | | 1976 | 816180 |
| schistosoma mansoni in baboons. iii. the course and characteristics of infection, with additional observations on immunity. | parasitological, clinical, and histopathological observations on 54 baboons infected with schistosoma mansoni are presented. the baboon and s. mansoni constitute a compatible host-parasite system, evidence by the infectivity of cercariae (98% penetration, 42% adult worm recovery), and the long, fertile life of the worms. baboons tolerated the infection well, with clinical illness a rarity in moderately infected baboons. pathological findings were generally unremarkable. an acute "toxemic" phase ... | 1976 | 816218 |
| immunizing efficacy of a kenyan strain of schistosoma mansoni in rhesus monkeys (macaca mulatta). | the efficacy as an immunizing agent of the kenyan strain of schistosoma mansoni against challenge infection in rhesus monkeys was demonstrated. an initial exposure of 200 cercariae immunized monkeys against a challenge dose of 2,000 cercariae administered 16 weeks later. the penetration rate in rhesus monkeys was 99%, the same as in baboons. the prolongation of the time for immunity to develop in baboons, compared to rhesus monkeys, shown with this strain of s. mansoni is therefore not due to a ... | 1976 | 816221 |
| [the effect of an inflammatory reaction induced either by bcg or a non-biodegradable irritant on the resistance to bilharziasis in mice]. | | 1976 | 816529 |
| immunoglobulins attached to and in the integument of adult schistosoma mansoni sambon 1907, from first infection of cf mice. | 7sgamma2b antibody was found attached to and in the integument of adult schistosoma mansoni removed from cf1 white mice. with the techniques used, iga, igm, 7sgamma1, 7sgamma2a, 7sgamma3, and c3 complement were not found to be attached to the integumental surfaces. 7sgamma2b does not seem to fix c3, and it is suggested this antibody may be acting in enhancing and blocking roles which protect the worms from the host. | 1976 | 817010 |
| 4-isothiocyanato-4'-nitrodiphenylamine (c 9333-go/cgp 4540), an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes. | 4-isothiocyanato-4'-nitrodiphenylamine was found to possess activity against intestinal nematodes in mice, against schistosomes in various hosts including primates and against two filarial species in the mongolian jird. upon administration in a single oral dose it is equally effective against s. haematobium, s. mansoni and s. japonicum. | 1976 | 817928 |
| [antigenic structure of hemolymph and tissue extract of biomphalaria glabrata infested or not infested with schistosoma mansoni]. | | 1975 | 819148 |
| soluble antigens and antibodies in sera from baboons infected with schistosoma mansoni. | | 1976 | 820807 |
| analysis of the movements of schistosoma mansoni miracida using dark-ground photography. | a dark-ground photographic technique was used to study the effects of several physical and chemical conditions on the behavior of schistosoma mansoni miracidia. miracidial speed was affected by miracidial aging, temperature, light intensity, and to a small extent by snail conditioned water (scw). rates of change of direction were influenced by miracidial aging, sudden increases in light intensity, and by scw at 20%, 60%, and 100% concentrations. adaptation to 20% scw was apparent within 40 min o ... | 1976 | 824430 |
| immunocytochemical localization of igg on adult schistosoma mansoni tegumental surfaces. | | 1976 | 824432 |
| [variations in the immune response in several schistosome-rat infections]. | the evolution of immunological reactions in two rat strains, namely rattus rattus from guadeloupe and rattus norvegicus var. albinos, was studied. both have beem experimentally infested by three different strains of schistosoma mansoni. we observed that rattus rattus infested by the american strains reacts poorly and shows a persistant infection contrary to the results obtained with other infestations. so it appears that a special pathogenic complex might be present in guadeloupe which could exp ... | 1976 | 825253 |
| schistosoma mansoni in baboons. antibody-dependent cell-mediated damage to 51cr-labelled schistosomula. | a technique is described for estimating cell-mediated damage to the larval stages of schistosoma mansoni that occur in the mamalian host (schistosomula), by measuring release of 51cr from labelled organisms. this technique, although widely used for assaying cytotoxicity to single cell suspensions or monolayers, has not previously been applied to a multicellular parasite. it is more objective than microscopical assays, and allows the processing of larger numbers of samples. the new method has bee ... | 1976 | 825338 |
| effect of schistosoma mansoni on plasma cholinesterase activity in rhesus monkeys. | | 1976 | 825382 |
| immunisation of baboons against schistosoma mansoni using irradiated s. mansoni cercariae and schistosomula and non-irradiated s. rodhaini cercariae. | in an attempt to develop a non-pathogenic procedure for immunising baboons against s. mansoni, groups of five baboons were exposed to three doses of 5000 6 kr-irradiated s. mansoni cercariae or to similar numbers of normal s. rodhaini cercariae and challenged at week 15 with 500 normal s. mansoni cercariae. faecal egg counts, worm and tissue egg counts, and histopathological examination, showed that neither of the immunising schedules had produced significant protection. in the second experiment ... | 1976 | 825552 |
| schistosoma mansoni soluble egg antigens. i. identification and purification of three major antigens, and the employment of radioimmunoassay for their further characterization. | a cell-mediated immunologic granulomatous response to schistosoma mansoni eggs is now generally accepted as being responsible for the hepatosplenic disease of chronic schistosomiasis. previous investigations have demonstrated that a soluble extract of s. mansoni eggs (sea) both induces and elicits granulomatous hypersensitivity and other forms of cell-mediated immunologic reactivity. mice with chronic light s. amnsoni infections show spontaneous suppression of granulomatous hypersensitivity in t ... | 1976 | 826590 |
| in vitro effect of the lethal antibody on schistosomula in sera of rhesus monkeys immunized with highly x-irradiated cercariae. | the in vitro effect of the lethal antibody on schistosomula in sera of rhesus monkeys immunized with highly x-irradiated cercariae of schistosoma mansoni or s. japonicum was studied. in all 6 experimental monkeys, 4 unchallenged and 2 challenged, the effects of lethal antibody on schistosomula were demonstrated. the sera of the challenged monkeys had no stronger lethal effect than those of the unchallenged monkeys. this shows that the lethal antibody can be produced by the antigenic stimulation ... | 1976 | 826615 |
| renal biopsy in schistosoma-salmonella associated nephrotic syndrome. | percutaneous needle biopsy of the kidney on eight nephrotic patients with schistosoma mansoni and chronic salmonella paratyphi a infection showed diffuse proliferative glomerular change in all biopsies. capillary basement membrane was normal. diffuse granular deposits were detected in the glomerular mesangial cells by direct staining with fluorescein labelled anti-igg anti-igm. no fluorescence was obtained with rabbit anti-salmonella paratyphi a. after treatment with ampicillin and niridazole, a ... | 1976 | 827621 |
| [study of humoral immunity in human biharziasis. value of e.l.i.e.d.a. (enzyme-linked immunoelectrodiffusion assay)]. | with a view to sensitize the immuno-electro-diffusion test (i.e.d.) and determine the immunoglobulins involved in the antigen-antibody reaction, the authors have improved the i.e.d. test by coupling it with an enzymatic technique. the precipitated immune-complexes are treated with antibodies conjugated with an enzyme specific for each class of immuno-globulins. this association realizes the e.l.i.e.d.a. (enzyme-linked immuno-electro-diffusion-assay). the sensitivity and specificity of the method ... | 1976 | 828870 |
| recent advances in the diagnosis of schistosomiasis. | | 1976 | 829665 |
| serological diagnosis of schistosomiasis. 1 demonstration and significance of bilharzial antigenaemia. | circulating bilharzial antigens were demonstrated in 39% out of 87 bilharzial patients via the iha and cf techniques using hyperimmune rabbit anti - s.mansoni worm serum. correlation between the percentage of positive cases and the age, duration of infection, clinical presentation, type of bilharzial infection, chemotherapeutic effect and the intradermal test (i.d.t.) were made. the percentage of positive cases was found to increase with age and with the duration of infection. more positivity wa ... | 1976 | 829666 |
| the histopathology of early hepatic schistosomiasis. | | 1976 | 829718 |
| antibody-dependent eosinophil-mediated damage to 51cr-labeled schistosomula of schistosoma mansoni: damage by purieid eosinophils. | after earlier observations that antibody-dependent, cell-mediated damage to 51cr-labeled schistosomula can be ablated by pretreatment of a mixed preparation of human peripheral blood leukocytes with an anti-eosinophil serum and complement, we investigated the cytotoxic effects of eosinophil-enriched cell preparations. preparations containing up to 98.5% eosinophils and devoid of neutrophils were effective in mediating antibody-dependent damage to schistosomula. preparations enriched in mononucle ... | 1977 | 830787 |
| the cellular and humoral immune response to schistosoma mansoni infections in inbred rats. ii. mechanisms during reexposure. | | 1977 | 832318 |
| schistosoma mansoni: immunoglobulins involved in passive immunization of laboratory mice. | | 1977 | 838027 |
| schistosoma mansoni: pairing in vitro and development of females from single sex infections. | | 1977 | 838033 |
| schistosoma mansoni: resistance to reinfection in the rat. | | 1977 | 838034 |
| schistosomiasis in the congenitally athymic (nude) mouse. i. thymic dependency of eosinophilia, granuloma formation, and host morbidity. | athymic nude mice (nu/nu), heterozygous littermates (nu/+), and thymus reconstituted homozygous animals (nu/nu txr) were exposed to schistosoma mansoni cercariae. a marked impairment in the development of peripheral blood eosinophilia and hepatic granuloma was observed in the nu/nu animal. in addition, host morbidity judged by organ weight, portal pressures and reticuloendothelial activity were less in the nu/nu animal. thymus-reconstituted animals demonstrated eosinophilia, increased granuloma ... | 1977 | 839071 |
| skin tests and serological investigations for autoimmune reactivity to dna liver and kidney antigens in human schistosoma mansoni infections. | | 1976 | 841660 |
| morbidity from schistosoma mansoni in a puerto rican community: a population-based study. | a population-based approach was used to investigate morbidity from schistosoma mansoni in a rural community in eastern puerto rico that was representative of remaining endemic foci on the island. in 1974 the prevalence of infection 855 of 1,056 inhabitants was 32.7% and the geometric mean egg output was 17.6 eggs per gram. a standardized medical history was obtained, and physical and laboratory examinations were performed on 737 (70%) of the community residents. quantitative s. mansoni egg count ... | 1977 | 842771 |
| effect of schistosoma mansoni infection on pentobarbital-induced sleeping-time in mice. | the sleeping-time induced by sodium pentobarbital is greatly increased in mice experimentally infected with schistosoma mansoni. the degree of hypnosis is affected by the female worm burden, probably because the hepatic lesions produced by schistosome eggs cause slow metabolisation of anesthetics. | 1977 | 842782 |
| studies on schistosomal rectal and colonic polyposis. | anatomic and digestion studies were done on rectal and colonic schistosomal polyps from 30 patients. results indicate that schistosomal colonic polyposis is principally due to high, localized egg burdens of schistosoma mansoni or s. haematobium resulting in damage to the muscularis mucosa of the colon. furthermore, atypically focal oviposition by s. mansoni is probably more important in genesis of rectocolonic polyposis than is schistosomiasis haematobium. | 1977 | 842787 |
| schistosomal polyposis of the urinary bladder. | anatomic, clinical, and digestion analyses were done on 18 human urinary bladder polyps from patients with schistosoma haematobium infections. variations in histologic pattern conformed to stages in progression of the disease; most were from active cases with significant egg burdens. the data suggest that polypoid lesions of active schistosomiasis may persist as polyps in the inactive stage if antecedent active infection was heavy. | 1977 | 842788 |
| schistosomal ulceration of the urinary bladder. | clinical, anatomic and digestion studies were done in 91 surgically treated cases of bladder ulceration in egyptian patients with urinary schistosomiasis. most patients were rural male farmers; their mean age was 29 years. symptoms were similar to uncomplicated urinary schistosomiasis except for suprapubic or perineal pain. two clinicopathologic entities were noted: 1) sloughing of polypoid patches in early active disease; and 2) chronic schistosomal ulceration of the bladder occurring at sites ... | 1977 | 842789 |
| demonstration and mode of action of an inhibitor for activated hageman factor (factor xiia) of the intrinsic blood coagulation pathway from schistosoma mansoni. | an anticoagulant activity from adult schistosoma mansoni whole worm homogenate is described. the inhibitor appears to be specific for the contact activation step of the intrinsic pathway. experiments with both human and mouse plasmas have defined the specificity of the inhibitor as follows: (1) it lengthens the partial thromboplastin time of normal plasma. (2) it has no effect on the prothombin time and russell's viper venom time of normal plasma. (3) preactivation of normal plasma by a contact ... | 1977 | 843620 |
| nitrothiophenes with schistosomicidal activity. | | 1977 | 844553 |
| liver collagen synthesis in murine schistosomiasis. | collagen synthesis was measured in liver slices obtained from mice with hepatosplenic schistosomiasis. enlarged fibrotic livers from these mice contained 20 times more collagen than normal. this model of hepatic fibrosis results from an inflammatory granulomatous host response to schistosoma mansoni ova in portal tracts, rather than from direct lover cell injury as with carbon tetrachloride-induced liver fibrosis. collagen synthesis, as measured by the formation of labeled protein-bound hydroxyp ... | 1977 | 845255 |
| calcium carbonate content of the preacetabular glands of schistosoma mansoni cercariae. | | 1977 | 845731 |
| a method for in vivo labeling of schistosome miracidia with radioselenium. | | 1977 | 845732 |
| schistosoma mansoni: effects of zinc on cercarial and schistosomule viability. | the effects of zncl2 on the viability and morphology of cercariae and schistosomules of schistosoma mansoni were examined. the longevity of cercariae was inversely proportional to the zinc concentration from 0.05 to 5 micronm. zinc caused body-tail separation and crenation of bodies but not of tails of cercariae, as well as alteration of the staining of cercariae in the indirect immunofluorescence test. zinc was also effective in reducing penetration of cercariae into mice in a brief (10 min) ex ... | 1977 | 845744 |
| effects of stressful conditions on the development and movement of reproductive cells in schistosoma mansoni. | adult s. mansoni exposed to 3h-thymidine to label reproductive cells were cultured in vitro, maintained intraperitoneally, and transplanted to the hepatic portal vein of hamsters in unisexual infections. daily samples were taken, processed for autoradiography, and observed for abnormal morphological and development characteristics. males cultured in vitro did not produce labeled sperm and the testes exhibitied necrotic changes by the 5th day. vitelline cell formation was normal for the first 5 d ... | 1977 | 845745 |
| field trials with oxamniquine in a schistosomiasis mansoni-endemic area. | in peri-peri (minas gerais), an area endemic for schistosoma mansoni, 591 inhabitants were examined. a coprological survey showed a prevalence of infection of 43.7%. after clinical examination 220 patients were distributed into three groups for treatment with oxamniquine; in group 1, 19 children (2 to 15 years) were treated with a single oral dose of drug suspension around 20 mg/kg body weight; in group 2, 47 children were treated orally with two 10 mg/kg doses with a 6- to 8-hour interval betwe ... | 1977 | 848645 |
| comparative effects of hycanthone in schistosoma mansoni and schistosoma japonicum. | after in vitro hycanthone treatment followed by a 20-hour incubation in drug-free medium, schistosoma mansoni were still resistant to labeling by a fluorescent analog of acetylcholine. s. japonicum, in contrast with the hycanthone sensitive species, showed prompt reversal of the blocking effects of hycanthone on fluorescent labeling. this finding suggests that differences in the reversibility of hycanthone may correlate with the usefulness of the drug in the therapy of schistosome infections by ... | 1977 | 848646 |
| coagulation factor xiia (activated hageman factor) inhibitor from adult schistosoma mansoni. | an inhibitory activity for the contact phase of the intrinsic coagulation pathway was demonstrated in an extract of adult schistosoma mansoni. inhibition is apparently specific for the enzymatic activation of factor xi (pre-pta) by factor xiia (activated hageman factor). this phenomenon offers an explanation for the schistosomal evasive mechanism of the host contact hemostatic defense system. | 1977 | 848647 |
| immunological studies in human schistosomiasis. ii. antibodies cytotoxic for schistosoma mansoni schistosomules. | complement dependent cytotoxic antibodies for schistosoma mansoni schistosomules were studied in a brazilian population. the sera of s. mansoni-infected patients gave a high percentage of cytotoxicity (63.4%) compared with sera from persons not infected (8.7%). the igg class and the specificity of these cytotoxic antibodies are defined. the index of lethality appeared to be independent of the titers of other specific anti-s. mansoni antibodies. a statistical correlation was found between the ind ... | 1977 | 848648 |
| [immunosuppressive factors released by schistosoma mansoni]. | immunosuppressive factors were evidenced in cell-free supernatant of s. mansoni schistosomes culture and incubation products of the parasite. both parasitic materials decreased tritiated thymidine and leucine uptake in normal spleen cells from cba mouse and fischer rats and in peripheral human blood lymphocytes stimulated either by non specific mitogens (pha, cona, or lps) or by allogeneic cells. the suppressive factor(s) was (were) heat-resistant, dialyzable and of molecular weight 500-1,000. t ... | 1977 | 848905 |
| parasite 'm' antigen in milk from mothers infected with schistosoma mansoni (preliminary report). | | 1977 | 849016 |
| field trial of metrifonate in the treatment and prevention of schistosomiasis infection in man. | a field trial was set up to test the prophylactic properties of the organophosphorous drug metrifonate (bilarcil bayer ag). subjects were rural african children living in an area of rhodesia where schistosoma haematobium and s. mansoni are highly endemic. the trial was conducted in three stages, a preliminary period of therapy followed by two six-month periods of prophylaxis. parasitological and haematological tests were carried out monthly and major assessments (including clinical examinations) ... | 1977 | 849020 |
| plasma and erythrocyte lysolecithin schistosomiasis mansioni. | | 1977 | 849382 |
| schistosoma mansoni: kinetics and class specificity of hypergammaglobulinemia induced during murine infection. | | 1977 | 849767 |
| studies on resistance in snails: interference by nonirradiated echinostome larvae with natural resistance to schistosoma mansoni in biomphalaria glabrata. | | 1977 | 850073 |
| toxoplasmosis and the host-parasite relationship in murine schistosomiasis mansoni. | infection with toxoplasma gondii has been shown to suppress markedly the in vitro splenic lymphocyte response to nonspecific mitogens and the in vivo antibody response to sheep red blood cells. the effect of toxoplasmosis on an in vivo cell-mediated response, granuloma formation around schistosoma mansoni eggs, was examined in the present study. the granulomas were markedly suppressed from two to 20 weeks after infection with t. gondii. in subsequent experiments the effect of toxoplasmosis-induc ... | 1977 | 850078 |
| a lung model of schistosome immunity in mice. | when mice are challenged intravenously with schistosomula of schistosoma mansoni, host cell reaction and parasite attrition proceed entirely in the lung, where these events can be followed by quantitative histology and worm recovery. in nonimmune animals the destruction of schistosomula in the lungs proceeds gradually, resulting in the elimination of about 80% of the challenge organisms after 6 days. cell reaction begins promptly, as evidenced by the appearance of neutrophilic foci around many o ... | 1977 | 851162 |
| in vitro development of schistosoma mansoni cercariae. | early cercarial embryos of schistosoma mansoni developed to swimming cercariae within seven days in vitro, via the same sequence of stages as reported in vivo. the presence of living biomphalaria glabrata cells (bge line) was indispensable for proper development. cultured cercariae were water-sensitive, gave no cercarienhüllen reaction, and appeared to lack the surface glycocalyx. further development was not detected in mice or hamsters. | 1977 | 859081 |
| the diagnosis of bilharziasis. | in addition to the classical manifestations, bilharziasis may present with features which are atypical and which may simulate other conditions. in such cases the value of the previous history cannot be overemphasized, immunodiagnostic procedures are useful pointers in diagnosis but in general treatment should be undertaken only after ova of the parasites have been found. | 1977 | 860181 |
| serological investigations on patients with schistosomiasis with special reference to circulating antigen. | serological tests on patients with s. haematobium and s. mansoni indicated that both antibody and schistosome antigen can be detected. the possible role of these in immune-complex nephritis is discussed. | 1977 | 860325 |
| schistosomal myelopathy. | | 1977 | 861565 |
| schistosoma mansoni: in vitro stimulation of vitelline cell development by extracts of male worms. | | 1977 | 862702 |
| schistosoma mansoni: susceptibility reversal with age in the snail host biomphalaria glabrata. | | 1977 | 862703 |
| single sex cercariae of schistosoma mansoni, a comparison of male and female infectivity. | | 1977 | 864228 |
| immunoprecipitins in human schistosomiasis detected with adult worm antigens released by 3m kc1. | | 1977 | 864229 |
| nasal and paranasal pathology in experimental bilharziasis. | the heads of ten white mice experimentally infested by bilharziasis were processed to examine the nasal and paranasal cavities. five normal littermates served as controls. the incidence of pathology in these cavities was exceptionally high in the diseased group (100 per cent). lymphoid hyperplasia was noticed in many cases while one case showed bilharzial eggs in relation to the nasal walls. the significance of these findings and their relationship to human bilharziasis is discussed. | 1977 | 864315 |
| modification of the lung recovery assay for schistosomula and correlations with worm burdens in mice infected with schistosoma mansoni. | the kinetics of recovery of schistosomula from the lungs of previously-unexposed cf1 mice were studied following infection with schistosoma mansoni cercariae. lung tissue fragments were incubated from 3 to 48 hr and the completeness of recovery of viable schistosomula was determined. the recovery of schistosomula from the lungs was shown to correlate closely with 7-week worm recoveries. with the additional incubation described, the lung recovery assay may provide a more defined indicator of prot ... | 1977 | 864557 |
| the host-parasite interface of trematodes. | | 1977 | 868682 |
| prevalence and intensity of schistosoma haematobium and s. mansoni infection in qalyub, egypt. | we report the preliminary findings of a comprehensive schistosomiasis survey in the qalyub region of the nile delta. a systematic sample of households in eight villages was studied, and 8,712 individuals submitted stool and urine specimens for parasitologic examinations. the prevalence of schistosoma mansoni infection (40.5%) was much higher than that reported previously in this area, and the prevalence of s. haematobium (27%) was much lower. the geometric mean egg output for both parasites was ... | 1977 | 869100 |