| evaluation of an experimental mollusciciding programme to control schistosoma mansoni transmission in st lucia. | the size and number of colonies of biomphalaria glabrata were reduced after four years of a surveillance/treatment snail control programme using an emulsifiable concentrate of niclosamide (25% active ingredient). surveys among the human population showed that the incidence of new schistosoma mansoni infections in 0-10 year-old children fell from 22% to 4.3%, while in a comparison area the incidence remained at 20%. with reduced transmission over four years, the prevalence of infection in a cohor ... | 1978 | 307443 |
| quality control in laboratory investigations on schistosoma mansoni on st lucia, west indies: a staff assessment scheme. | a method is described for the supervision of technicians engaged in microscopical screening of large numbers of stools for schistosoma mansoni ova. the scheme presents graphically a regularly updated longitudinal evaluation of both individual and group standards of technical competence. | 1978 | 307457 |
| the cellular and humoral immune response to schistosoma mansoni infections in inbred rats. v. prerequisite mechanisms for the development of optimal protective immunity. | | 1978 | 307984 |
| the immune-dependence of schistosomicidal chemotherapy: relative lack of efficacy of an antimonial in schistosoma mansoni-infected mice deprived of their t-cells and the demonstration of drug-antiserum synergy. | when t-cell deprived cba mice, infected with schistosoma mansoni, were treated orally with potassium antimony tartrate, the reduction in size of their worm burdens was less than in similarly treated, immunologically-intact animals. the defect in deprived mice could be restored by the administration of serum obtained from s. mansoni-infected normal mice simultaneously with the drug, but by a different route. a serum component, probably immunoglobulin, obtained from rabbits which had been injected ... | 1978 | 309809 |
| immune response of guinea pigs to schistosoma mansoni. ii. in vitro blastogenesis and macrophage migration inhibition factor production in response to cercarial, adult worm and egg antigens. | guinea pigs infected with schistosoma mansoni were tested for in vitro lymphocyte response to schistosome antigens and nonspecific mitogens at various times after infection. production of macrophage migration inhibition factor by peritoneal exudate cells in response to cercarial, adult, and egg antigens reached a peak between 4 and 8 weeks post-infection and diminished rapidly thereafter. in contrast, peak blastogenic responses of blood lymphocytes appeared later than 8 weeks for all antigens an ... | 1977 | 333964 |
| the eosinophil and its role in immunity to helminth infection. | | 1977 | 336298 |
| studies on the host-parasite relationship in schistosoma mansoni-infected mice: the immunological dependence of parasite egg excretion. | cba mice deprived of their t cells by means of thymectomy and anti-thymocyte serum and subsequently infected with schistosoma mansoni were found to have substantially fewer parasite eggs in their faeces than similarly infected immunologically-intact control animals. the number of parasite eggs deposited in the tissues of t-cell deprived mice was by comparison only marginally lower than in control mice. administration of serum obtained from normal mice with chronic s. mansoni infections partially ... | 1978 | 309856 |
| quality control in laboratory investigations on schistosoma mansoni in st. lucia, west indies. maintenance of artificial prevalence as a laboratory aid. | a method is described of maintaining an apparent s. mansoni prevalence rate of 10% in an area estimated to have a natural rate of below 5% following two chemotherapy campaigns. to sustain interest and therefore accuracy among microscopists engaged on screening, known s. mansoni-positive stools were seeded, without their knowledge, among those collected in the field. the problems of achieving a desired level of seeding, and of a possible further dimension of the scheme are discussed. | 1978 | 310366 |
| further observations from st lucia on control of schistosoma mansoni transmission by provision of domestic water supplies. | individual households in five settlements were provided with piped water in a pilot scheme to investigate the effect on transmission of s. mansoni in st lucia. nearby comparison settlements, in the same valley, were provided with water through a public standpipe system. the incidence of s. mansoni infection among children decreased in the experimental area, leading to lower prevalence rates and lower intensity of infection in all age groups. over the study period, indices of infection increased ... | 1978 | 310737 |
| [treatment of schistosomiasis mansoni: current aspects]. | | 1977 | 311025 |
| genetic differences in bcg-induced resistance to schistosoma mansoni are not controlled by genes within the major histocompatibility complex of the mouse. | induction of nonspecific resistance to schistosoma mansoni infection after the i.v. injection of viable bcg was investigated in outbred mice and a panel of inbred and h-2 congenic strains. significant protection was induced in cf1, a/j, c57bl/6, c57bl/10, dba/2, c57br, and sjl mice. balb/c mice were not protected whereas cba and c3h mice expressed intermediate degrees of protection. expression of the protective phenomenon is not controlled by genes within the mhc as shown by the marked differenc ... | 1978 | 344795 |
| [inferior cavography in portal hypertension syndrome due to hepatosplenic schistosomiasis mansoni]. | | 1979 | 317672 |
| schistosoma mansoni and schistosoma japonicum: comparison of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in adults. | glucose-6-phosphate dehydrogenase activity in paired adult schistosoma mansoni is about twice as great as in paired adult schistosoma japonicum. 2. 6-phosphogluconate dehydrogenase activity accounts for 25.8% of the measured production of reduced nicotinamide adenine dinucleotide phosphate (nadph) in s. japonicum but only 8.6% of the measured production of nadph in s. mansoni. 3. these data suggest a species difference in 6-phosphogluconate metabolism. | 1977 | 318249 |
| oxygen uptake and lactate production by schistosoma mansoni cercaria, cercarial body and tail, and schistosomule. | 1. oxygen consumption by schistosoma mansoni cercarial bodies varies, with the batch of organisms, the incubation media and the temperature (27-37 degrees c), from 27.4 +/- 3.4 to 55.0 +/- 4.8 microliters o2/mg larval protein per hr. it is proportional to the concentration of organisms incubated, up to 25,000/ml, as calculated from whole protein. 2. oxygen uptake by cercariae is inhibited by 5.6 mm glucose in the incubation media, a concentration that stimulates the respiration of cercarial bodi ... | 1978 | 318321 |
| alterations of the free amino acid content in the hemolymph of biomphalaria glabrata (pulmonata) in starvation and after infection with schistosoma mansoni (trematoda). | 1. analysing the free amino acid content of the hemolymph of normally fed, starved and schistosome-infected biomphalaria glabrata we identified 22 amino acids and amines, respectively. 2. in comparison with normally fed snails the free amino acid content of starved and infected snails was significantly reduced. 3. however, only slight differences between the ornithine and citrulline content occurred in the three test groups. | 1979 | 318425 |
| mutagenic activities in vitro and in vivo of five antischistosomal compounds. | five antischistosomal compounds--hycanthone, two of its chloroindazole analogs (ia-4 and ia-4 n-oxide), oxamniquine, and metrifonate--were tested for mutagenic activity, using salmonella typhimurium strains ta 98 and ta 100 under in vitro and in vivo (host-mediated) conditions. in all assay systems hycanthone exhibited by far the highest mutagenic potency. although oxamniquine and metrifonate had low metagenic activity in vitro and although their administration resulted in urine of low metagenic ... | 1977 | 319220 |
| anthelmintics. | this article describes the drugs used in helminthic infections and their therapeutic indications, mode of action, toxicity and other details of each of the recommended drugs, and discusses the nature and treatment of infection by helminths important in human medicine. infestation due to the roundworms enterobius vermicularis, ascaris lumbricoides and the hookworms, ancylostoma duodenale and necator americanus can all be treated effectively with pyrantel pamoate. for enterobius vermicularis, howe ... | 1977 | 319991 |
| ige in experimental schistosomiasis. ii. quantitative determination of specific ige antibodies against s. mansoni: a follow-up study of two strains of infected rats. correlation with protective immunity. | parasite specific ige antibodies in rats infected with schistosoma manoni were measured by passive cutaneous anaphylaxis (pca) reactions and by the technique of immuno-adsorption. two strains, one a low ige producer (fischer rats) and the other a high ige producer (hooded-lister rats) were studied. in fischer rats, a time course study of the occurrence of ige antibodies and resistance to reinfection was made. parasite specific ige levels measured by immuno-adsorpiton were much lower than total i ... | 1978 | 355126 |
| [sero-immunological research by immunofluorescence of rats bilharziosis in guandeloupe. epidemiological interest, comparative studies in various biotopes (author's transl)]. | a sero-immunological survey by immunofluorescnece has been conducted on 94 rats (r. rattus and r. norvegicus) captured in guadeloupe, in there different biotopes where the presence of s. mansoni carriers had been reported. these biotopes are those of the "grand etang" (great pond), the fresh-water mangrove and its back-mangrove area, and the beaugendre valley. the post-mortem performed on the rats revealed that 92 % of those carrying. s. mansoni eggs of full-grown worms, had a rate of antibodies ... | 1978 | 358899 |
| schistosoma mansoni infection in intact and b cell deficient mice: the effect of pretreatment with bcg in these experimental models. | the course of infection with schistosoma mansoni was determined in b cell deficient mice by means of a schistosomule lung recovery assay 6 days after infection or by determination of the adult worm burden 7 weeks after infection. the intensity of infection was not significantly different from that in age- and sex-matched intact controls. b cell deficiency was demonstrated by absence of surface immunoglobulin-bearing cells in the spleen and by absence of b cell areas in the lymphoid follicles of ... | 1978 | 362959 |
| schistosoma mansoni: comparison of the immunoperoxidase techniques, dass and elisa, for human diagnosis. | | 1977 | 320025 |
| factors affecting the acquisition of resistance against schistosoma mansoni in the mouse. iv. the inability of t-cell-deprived mice to resist re-infection, and other in vivo studies on the mechanisms of resistance. | | 1979 | 314086 |
| schistosoma mansoni: a comparative study of artificially transformed schistosomula and schistosomula recovered after cercarial penetration of isolated skin. | a comparison was made of the ultrastructure, development and antigenic nature of the surfaces and of the viability of three types of schistosoma mansoni: schistosomula formed after cercariae had penetrated isolated skin (ss) schistosomula produced after mechanical separation of cercarial tails from bodies (ms), and schistosomula transformed from cercariae after incubation in fresh rat serum (rs). within 2h of transformation, the surface membranes of all three types of schistosomula had changed f ... | 1977 | 320543 |
| immune competence and diabetes mellitus. ii. experimental mouse studies. | | 1979 | 370458 |
| drugs as ligands of immunogenic molecules in parasites: an approach to the isolation of target-antigens. | schistosomicide drugs are used as ligands to isolate the target antigens of schistosome by affinity chromatography. anti-target antigens immune sera produced in rabbit permit their localization on the parasite using immunofluorescence. target antigens of some drugs determine a relatively high immunoprotection in rat or mouse schistosomiasis infection. | 1977 | 321693 |
| [an epidemiological study of foci of s. mansoni bilharziosis in minkana and nalassi (lekie division, cameroun) (author's transl)]. | the epidemiological survey involved the examination of the total population of the two villages as well as the investigation of the freshwater snails in the neigbouring waters bodies. biomphalaria camerunensis and biomphalaria pfeifferi were found to be the intermediate hosts of schistosoma mansoni. the cassage of eggs in the stools was more frequently observed in two groups, those aged 10-19 years and in the elderly women. the study of the prevalence of the disease by means of the indirect immu ... | 1978 | 373026 |
| in vitro killing of schistosomula of schistosoma mansoni by bcg and c. parvum-activated macrophages. | resistance to schistosoma mansoni infection in the mouse has been induced either specifically by a primary infection with this parasite or nonspecifically by a variety of immunostimulants such as bcg. in the present study we developed an in vitro system to examine the effector mechanism of nonspecifically induced resistance. activated macrophage monolayers obtained from bcg- or corynebacterium parvum treated mice killed a respective mean 32 +/- 6% and 48 +/- 5% of schistosomula after 24 hr incub ... | 1979 | 376723 |
| modification of a new technique for immunohistochemical localization of cell surface components. | | 1979 | 376822 |
| fibrin deposition and clearance in chronic granulomatous inflammation: correlation with t-cell function and proteinase inhibitor activity in tissue. | patterns of fibrin deposition were investigated by immunofluorescence microscopy in livers of thymus intact (ti) and athymic (at) mice infected with schistosoma mansoni. thrombin and fibrinolysis inhibitor activity in tissue extracts also were measured. in ti mice fibrin was detected perivascularly by 6 weeks after infection and at 8 weeks it was found over the granulomas as they developed. fibrin was cleared from the center of granulomas by 10 weeks. thrombin inhibitor activity increased at 4 t ... | 1979 | 315978 |
| decreased binding of cytotoxic antibody by developing schistosoma mansoni. evidence for a surface change independent of host antigen adsorption and membrane turnover. | schistosoma mansoni schistosomula maintained in chemically defined culture media became increasingly resistant to the cytotoxic effects of infected guinea pig serum. two- and 6-day-old schistosomula recovered from mice showed no uptake of igg antibody from infected guinea pig serum, as revealed by the indirect fluorescent antibody test. results from this test remained negative when the schistosomula were tested at 0 c, after exposure to drugs which inhibit synthetic and secretory processes, or a ... | 1977 | 325186 |
| a controlled trial of hycanthone and placebo in schistosomiasis mansoni in st. lucia. | | 1977 | 326208 |
| preliminary results in human schistosomiasis with ro 11-3128. | | 1979 | 380021 |
| schistosoma mansoni: impairment of the cell-mediated immune response in mice. | skin-graft rejection in mice experimentally infected with schistosoma mansoni is delayed when grafting is performed 60 days after the infection. in mice infected 30 days prior to the grafting, the grafts were rejected at the same time both in infected and in control animals. this observation indicates that impairment of cell-mediated immune response occurs in mice with mature s. mansoni infections. | 1977 | 326446 |
| host antigens and parasite antigens of murine schistosoma mansoni. | an indirect fluorescent antibody technique was used to detect mouse host antigens and parasite antigens on the surface of schistosoma mansoni. a rabbit anti-mouse rbc antiserum to detect host antigens, and serum from mice immune to s. mansoni was used to detect parasite antigens. schistosomula prepared after penetration of isolated mouse skin did not possess host antigens but bound antibody from immune serum (immune antibody); schistosomula recovered from the lungs of mice five days after infect ... | 1977 | 327628 |
| suppression of cell-mediated immunity by metronidazole. | metronidazole administered orally in doses of 20 and 200 mg/kg daily suppressed granuloma formation around schistosoma mansoni eggs which were injected intravenously and lodged in the pulmonary microvasculature of mice. the same doses did not suppress granuloma formation in animals which had previously been sensitized to the eggs. nonspecific granulomatous inflammation around divinyl benzene copolymer beads was unaffected by the drug. in a daily dose of 20 mg/kg, metronidazole inhibited delayed ... | 1977 | 328408 |
| elution of renal antischistosome antibodies in human schistosomiasis mansoni. | elution of complexed immunoglobulins was carried out in renal tissue obtained at autopsy from schistosomiasis mansoni and control cases. substantial amounts of igg were found in acid eluates of 2 of 5 schistosomiasis cases and 2 of 3 controls. the igg from schistosomiasis cases produced specific indirect immunofluorescence reactions in gut and tegument of sections of adult schistosoma mansoni; no reactivity was present against egg granulomas, cercariae, or mouse liver tissue. control case eluate ... | 1977 | 329698 |
| immunosuppression mediated by adult worms in chronic schistosomiasis mansoni. | a marked reduction in the number of plaque-forming cells from spleens of mice infected with schistosoma mansoni to sheep erythrocytes (srbc) and lipopolysaccharide from escherichia coli was observed. this reduction coincided with the late stages of the infection and was also observed in unisexual infection with male worms. treatment of the animals with a schistosomicidal compound (oxamniquine) almost completely abolished the immunosuppression. the suppression could be induced by administration o ... | 1977 | 329699 |
| immune responses during human schistosomiasis mansoni. iii. regulatory effect of patient sera on human lymphocyte blastogenic responses to schistosome antigen preparations. | | 1977 | 333963 |
| evaluation of the indirect immunofluorescence and complement fixation tests for the serodiagnosis of schistosomiasis. | sera from patients with a variety of infections were used to compare the sensitivity and specificity of the complement fixation (cf) and the indirect immunofluorescence (iif) tests for schistosomiasis. adult antigens were used in both tests. the sensitivities of the iif and cf tests were 95% and 69%, respectively; the specificities were 98% and 100%, respectively. there was no statistical difference between the number of positive reactors among those individuals with no detectable helminth infec ... | 1977 | 339755 |
| immunity to schistosomes: the target. | | 1977 | 339756 |
| modulation of immunopathology and disease in schistosomiasis. | | 1977 | 339757 |
| [serum enzymes in patients with schistosomiasis mansoni]. | | 1979 | 316555 |
| comparative clinicopathological and bacteriological studies in schistosomiasis mansoni. | fifty male egyptian inpatients with active colonic mansoniasis were studied clinicopathologically, endoscopically, radiologically and bacteriologically. this was done to find out the pattern of colonic and urinary enterobacteria and serum antisalmonella agglutinins in various stages of mansoniasis. cases are divided into three groups (a, b and c) according to the stage of their hepato-splenomegally. their clinical presentations were dysentery, rectal bleeding, abdominal distension, anaemia, endo ... | 1978 | 348448 |
| serum immunoglobulin concentrations, malarial and schistosomal antibodies in patients with massive splenomegaly in malawi. | serum immunoglobulin concentrations, malarial antibodies and schistosomal antibodies were measured in 33 patients with a provisional diagnosis of schistosomal splenomegaly, 16 with tss of presumed malarial aetiology and in 52 controls. igg and igm were higher in both splenomegaly groups than in the controls and igg was significantly higher in patients with schistosomal splenomegaly than in tss. although a very high igm was found more often in the tss group, there was no significant difference be ... | 1979 | 393837 |
| metrifonate trial in the treatment of various presentations of schistosoma haematobium and s. mansoni infections in the sudan. | the effect of metrifonate (bilarcil bayer) on schistosoma haematobium and s. mansoni infections was studied in 174 patients near khartoum. a high cure rate was obtained in s. haematobium infections, but anthelmintic efficacy was minimal in patients passing s. mansoni eggs in their stools. there was, however, a marked reduction of egg output in patients passing s. mansoni eggs in urine. this suggests that the site of infection in man, rather than the species of parasite, renders the parasite more ... | 1978 | 352282 |
| evaluation of lung recovery assay for schistosomula in mice immunized with x-irradiated cercariae of schistosoma mansoni. | the lung recovery assay for schistosomula has recently been used as a rapid method for measuring the state of immunity of a challenged animal. its merit rests on the fact that the peak day of schistosomular recovery in the lungs of both normal and immune hosts falls on the same day and the degree of immunity can be measured by the percent of schistosomular recovery on this particular day. an evaluation of this method for mice immunized with highly x-irradiated cercariae of schistosoma mansoni wa ... | 1979 | 395784 |
| the development of stage-characteristic immunofluorescence patterns in experimental schistosomiasis in mice. | | 1978 | 352286 |
| pattern of class-specific fluorescent antibodies according to the stage of the infection in human schistosomiasis mansoni. | | 1978 | 353958 |
| oxamniquine in the treatment of various schistosome infections in south africa. | trials of a new schistosomicide oxamniquine (vansil) were carried out in the lowveld of the eastern transvaal. after initial dose-finding trials, the safety and efficacy of oxamniquine against schistosoma mansoni at an oral dose of 15 mg/kg twice a day for 2 days (total dose 60 mg/kg), were confirmed. no detectable effect was noted against s. haematobium or s. mattheei. | 1978 | 354047 |
| genetic modification of macrophage functions in relation to antibody responsiveness and resistance to infection. | | 1979 | 397751 |
| species specificity of the immediate hypersensitivity to schistosomal proteolytic enzyme. | an acidic proteolytic enzyme which digests host haemoglobin can be isolated and purified from schistosomes. this small glycoprotein is an allergen which sensitizes the host, as shown by immediate hypersensitivity reactions. these are specific for either schistosoma haematobium or s. mansoni and can be demonstrated by mast cell degranulation in mice or by intradermal skin tests in monkeys. although high levels of total ige may be found in acute and chronic schistosomiasis, there was no evident re ... | 1979 | 399332 |
| immunodiagnosis of infection with schistosoma mansoni: enzyme-linked immunosorbent assay for detection of antibody to circulating antigen. | a circulating antigen, a negatively charged polysaccharide from the trematode schistosoma mansoni, was noncovalently bound to the surface of poly(l-lysine)-coated wells in polystyrene trays, which were then used in a micro-enzyme-linked immunosorbent assay (elisa) test. the method provides an immunodiagnostic test for schistosomiasis of exceptional sensitivity with a high degree of specificity. comparison of bell egg counts and elisa titers revealed a good correlation (r congruent to 0.80) in yo ... | 1978 | 364488 |
| isolation of a serologically important egg antigen of schistosoma mansoni and its application in the elisa. a preliminary report. | | 1979 | 400466 |
| trends in the development of chemotherapy for parasitic diseases. | | 1978 | 364672 |
| schistosoma mansoni: antigenic characterization of malate dehydrogenase isoenzymes and use in the defined antigen substrate spheres (dass) system. | | 1978 | 365558 |
| potentiation of schistosome granuloma formation. by lentinan--a t-cell adjuvant. | lentinan is a fungal polysaccharide which acts as a t-cell adjuvant. when this glucan was administered to thymus-intact mice by intraperitoneal injection, conspicuously enlarged lung granulomas formed in response to either schistosoma mansoni or s japonicum eggs or to antigen-coated polyacrylamide beads. liver granulomas in cercaria-induced s mansoni infection were augmented up to eight-fold in volume. by contrast, nude mice showed a complete absence of hypersensitivity granulomas, regardless of ... | 1979 | 371408 |
| the enzyme-linked immunosorbent assay (elisa) for the immunodiagnosis of schistosomiasis. | the enzyme-linked immunosorbent assay (elisa) done with soluble egg antigens (sea) of schistosoma mansoni was utilized for the detection of infections with schistosomes. the method readily detected experimental infections in nih outbred, new zealand black, and new zealand white mice by 6-10 weeks post-exposure to s. mansoni cercariae. in addition, the test was negative when the sera from 11 puerto rican normal controls were examined and was positive in 8 of 10 serum samples from humans with schi ... | 1979 | 378001 |
| the role of circulating immune complexes in the glomerular disease of experimental hepatosplenic schistosomiasis. | the serological and renal changes were studied simultaneously in 115 mice infected with schistosoma mansoni. igg and igm, but not iga anti-s. mansoni antibodies were detected in the sera, together with circulating immune complexes containing schistosomal antigen. glomerular mesangial deposits of iga, igm and c3 were observed. despite the strong correlation observed between the occurrence of the circulating immune complexes containing schistosomal antigen and the glomerular deposits, results conc ... | 1979 | 378479 |
| carrier effect during the course of experimental schistosomiasis: suppression of the response to tnp-schistosomula in rats and inbred mice. | | 1979 | 379213 |
| [changes in fluorescent antibodies in experimental bilharziasis with s. mansoni and s. haematobium in mice. comparison of the results obtained using homologous and heterologous antigens]. | fluorescent antischistosomiasis antibodies appear earlier in mice infected by 150/200 cercariae than in those who only received 20. the use of a homologous antigen in mice infected by s. mansoni or s. haematobium allows earlier and more important responses. the infections by s. haematobium seem to determinate in mice a more important immune responsiveness. is it a specific parasitic manifestation (s. mansoni being better adapted to rodents?). | 1978 | 383309 |
| [schistosoma mansoni and haematobium antisera tested by homologous and heterologous antigens. comparison of the results obtained by indirect immunofluorescence technic]. | the study of anti schistosoma mansoni and anti schistosoma haematobium sera by homologous and heterologous antigen shows that schistosoma haematobium has an immunogenic strength as good as that of schistosoma mansoni. the joint use of the two antigens can be useful in epidemiologic investigations in africa so as to track down seats of schistosoma mansoni and schistosoma haematobium and the prevalence of the infection. | 1978 | 383310 |
| [comparative study of the value of schistosoma mansoni and schistosoma haematobium antigens in the indirect immunofluorescent reaction applied to the diagnosis of rectal s. intercalatum bilharziasis]. | a comparative study of the value of antigenic sections of s. mansoni and s. haematobium in indirect immunofluorescence applied to the diagnosis of s. intercalatum rectal bilharziosis (in 66 cases) shows that far better results are obtained with s. haematobium antigen (83,3 0/0 positive reactions with higher titers dilution) than with s. mansoni (33,3 0/0 positive reactions). | 1978 | 385162 |
| the acquisition of antigens in the intercellular substance of mouse skin by schistosomula of schistosoma mansoni. | serum from patients suffering from the autoimmune skin disease pemphigus vulgaris has been used to demonstrate the presence of intercellular substance (ics) on the surface of these chistosomula of schistosoma mansoni which has penetrated mouse skin in vitro or during a percutaneous infection. ics was absent from mechanically transformed schistosomula or those formed in the peritoneal cavity of mice. schistosomula which penetrated mouse skin rapidly in vitro acquired very little of the ics. it wa ... | 1979 | 385180 |
| lysosomes in immunity to schistosomes and other helminths. | | 1979 | 387461 |
| the specific methods of control and eradication of schistosomiasis in israel. | a review of the epidemiological status of urinary schistosomiasis and intestinal schistosomiasis in israel is made. the ecology, bionomy and geographical distribution of the snail vectors were studied and research on their vectorial capacity to the imported schistosoma strains was undertaken. biomphalaria alexandrina, the snail vector of s. mansomi, was eradicated through ecological factors (salinity and pollution by sewage) and human activities. the elimination of snail vectors by applications ... | 1979 | 388774 |
| imported parasitic infections in tasmania. | a number of protozoan, trematode, and nematode infections have been imported into tasmania over an 18-month period. some of the cases are briefly discussed as they provide features of clinical interest. the increasing problem of imported infections in australia is emphasized. | 1979 | 390340 |
| a check list of definitive hosts exhibiting evidence of the genus schistosoma weinland, 1858 acquired naturally in africa and the middle east. | | 1977 | 340501 |
| polyvinylchloride (pvc) particles implantation in mouse liver. a technique for experimental study of schistosome eggs-induced liver pathology. | an injection of suspended pvc particles in the caecal vein of mice induces a foreign-body portal granuloma reaction in the liver. plastic casts of the portal system, after pvc particles implantation, show modifications in the portal bed and are compared with plastic casts obtained in mice infested by schistosoma mansoni. this technique can be useful to study the cellular dynamics of the portal granuloma and can be a model for schistosomal eggs induced liver pathology. | 1978 | 346371 |
| praziquantel, a new board-spectrum antischistosomal agent. | praziquantel, (2-cyclohexylcarbonyl)-1,2,3,6,7,11b-hexa-hydro-2h pyrazino[2,1a]isoquinolin-4-one, belongs to a new series of antischistosomal compounds. the results of a detailed study of the efficacy of praziquantel on schistosoma mansoni in mice, mastomys and syrian hamsters are described. praziquantel is effective after oral and all parenteral routes of administration tested. the amount of praziquantel required to achieve parasite reductions of at least 95% depends on the host species and on ... | 1977 | 410178 |
| indirect immunoperoxidase tests in the diagnosis of schistosomiasis. | an enzymatic technique, immunoperoxidase histochemistry, was applied in the diagnosis of human schistosomiasis. sera of patients with s. haematobium, s. mansoni and mixed infection, together with control sera, were studied. the test proved easily applicable and gave reliable results particularly with s. mansoni and double infection. the depth of the colour reaction, was then compared with elisa readings, but there was no relation in the results of the individual cases. | 1979 | 395743 |
| preliminary trials with praziquantel in human infections due to schistosoma mansoni. | as part of a programme of multicentre trials of the tolerance and therapeutic effect of praziquantel, clinical trials were carried out in brazil in patients with active schistosoma mansoni infections, each of whom had a minimum geometric mean egg output of 100 eggs per gram of faeces calculated from multiple pretreatment stool examinations.the first stage was a double-blind assessment of tolerance and efficacy of oral doses of 1 x 20, 2 x 20, or 3 x 20 mg of praziquantel per kg of body weight. s ... | 1979 | 396054 |
| pathways of nucleotide metabolism in schistosoma mansoni--vii. inhibition of adenine and guanine nucleotide synthesis by purine analogs in intact worms. | | 1977 | 410421 |
| immuno-enzymatic assay for the detection of schistosoma mansoni antigens in serum of mice harbouring bisexual or unisexual light worm infections. | enzyme-linked immunosorbent assay (elisa) double antibody technique was standardized for detecting s. mansoni polysaccharide and protein antigens in serum of infected mice. anti-sera specific for either worm components were obtained in sheep and peroxidase conjugates prepared from each serum. the immunoenzimatic test for protein could detect as little as 6 micrograms/ml antigens, and the test for polysaccharides 3 micrograms/ml. both bisexual and unisexual male worm low infections were produced, ... | 1979 | 396318 |
| the pattern of parasitic infection in villages of lagos state, nigeria. | | 1979 | 396698 |
| efficacy of oxamniquine in treatment of s. mansoni in a closed community in egypt and the concomitant administration of both metrifonate and oxamniquine in mixed infections. | | 1978 | 400362 |
| some biochemical changes in schistosomiasis mansoni. | | 1979 | 400655 |
| comparison of proteolytic enzymes from cercarial extract and secretion. | | 1977 | 400903 |
| schistosoma mansoni: inhibition of cercarial "penetration" proteases by components of mammalian blood. | 1. normal human sera and plasma were fractionated in order to identify inhibitors of the "penetration" proteases of schistosoma mansoni cercariae. 2. the main inhibitor, accounting for 90% of the total activity of serum, appears to be alpha 1-antitrypsin (alpha 1-at) as identified by separation on deae-cellulose and sephadex, by immunoelectrophoresis and by anticercarial protease activity of purified alpha 1-at preparations. 3. the inhibition profiles of purified preparations of the 6 known seru ... | 1977 | 400950 |
| the formation and turnover of the membranocalyx on the tegument of schistosoma mansoni. | the multilaminate vesicles present in the tegument cytoplasm appear to fuse with side channels projecting out into the cytoplasm from the base of the surface pits. their lamellate contents then unroll and spread out to form a trilaminate membranocalyx lining the pits and covering the tegument surface. the plant lectin concanavalin a appears to stabilize the process of vesicle fusion leading to an aggregation of multilaminate vesicles trapped in the lumen of the surface pits. the membranocalyx ca ... | 1977 | 402626 |
| patas monkey (erythrocebus patas) naturally infected with schistosoma mansoni. | | 1977 | 403268 |
| [differences in the sensilla of african and american cercaria of schistosoma mansoni, the agent of human intestinal bilharziasis]. | schistosoma mansoni parasite of the human intestinal bilharziasis is frequently transmitted in africa by the snail biomphalaria pfeifferi and in america by biomphalaria glabrata. the comparison between four african strains of cercariae obtained from biomphalaria pfeifferi and five american strains from biomphalaria glabrata points out variations in the number and arrangement of the sensory receptors. | 1977 | 404049 |
| [detection of schistosomiasis in rats using micro blood sampling and immunofluorescence during an epidemiologic study]. | for a study of rat parasitism with schistosoma mansoni in guadeloupe, we used a technique of microbloodsampling followed by an immunofluorescence test. this method makes it possible to take the blood of the rats, the latter being then marked and set loose. it informs us of the presence of the parasite, the time of infestation, and the rats' movements relative to waterspots. | 1978 | 417849 |
| the reactions of schistosoma mansoni miracidia to light. | the reactions of schistosoma mansoni miracidia to artificial light were studied by direct observations, choice-chambers and a photographic technique, at room temperature and at 15 c. the miracidia responded positively to directed illumination, but did not aggregate in a lighted dish. photography indicated an orthokinetic response to light intensity, but sharp changes in light intensity had no detectable effect on miracidial behavior. at the lower temperature the response to a directed light beam ... | 1977 | 404417 |
| [experimental studies on the schistosomicidal activity of the aminobenzaldehyde derivative 80.647 (author's transl)]. | in a group of aminobenzaldehyde derivatives the 2-cholor-4-(1)-piperazinobenalazine showed to be highly active in golden hamsters (mesocricetus auratus), mastomys natalensis and capucine monkeys (cebus capucinus capucinus) against schistosoma mansoni, slightly active against s. mattheei and inactive against s. haematobium and s. japonicum. the d.c.m. in mice and hamsters was 50 mg/kg body weight after a single oral dose and 20 or 50 mg/kg body weight respectively when dosed once daily on 5 conse ... | 1977 | 404743 |
| wild reservoirs of schistosoma mansoni from caratinga, an endemic schistosomiasis area of minas gerais state, brazil. | among 472 small mammals trapped in the caratinga area of minas gerais, brazil, schistosoma mansoni infection was demonstrated in 6 of 9 procyon, 1 of 7 didelphis, 1 of 1 philander, 25 of 72 nectomys, and 16 of 383 various other rodents representing 20 species. the role of nectomys and procyon in maintaining endemicity needs further investigation. | 1979 | 434308 |
| erythrokinetic studies on baboons (papio anubis) with acute experimental schistosomiasis mansoni. | | 1977 | 407276 |
| receptors for c3 on rat peritoneal mast cells. | purified rat peritoneal mast cells adhere to schistosomula of schistosoma mansoni which have been pre-incubated in fresh normal rat serum. this cytoadherence reaction is dependent on complement and in particular on components of the alternative pathway. since antibodies to rat c3 but not igg block the attachment of the cells to the complement-treated larvae, it appears that c3-specific receptors on the mast cell surface are responsible for the adherence phenomenon. these receptors can also be de ... | 1977 | 407303 |
| interactions between human eosinophils and schistosomula of schistosoma mansoni. ii. the mechanism of irreversible eosinophil adherence. | previous work (1)(1) has shown that normal human eosinophils show a preferential capacity, in comparison with neutrophils, to bind to antibody- coated schistosomula of schistosoma mansoni. this effect is attributable to a temperature-dependent function of the eosinophil which renders its binding stable and irreversible by aggregated gamma globulin or staphylococcus aureus protein a. in contrast, the binding of neutrophils is readily reversible by these agents. it has now been shown that the diff ... | 1979 | 390086 |
| in vitro schistosomulicidal effect of immune serum and eosinophils, neutrophils and lymphocytes. | | 1977 | 407358 |
| [influence of reintervention by the bacillus of calmette and guérin (bcg) on the nonspecific resistance of the mouse to schistosoma mansoni (author's transl)]. | significant resistance to schistosoma mansoni appears in mice two weeks after treatment with bcg. the state of nonspecific resistance is considerably increased if the injection of bcg two weeks prior to the infestation test is carried out using mice who have already received bcg. thus, bcg innoculation in an organism presentized to the bacillus antigens increases immunostimulation. according to these results, during primoinnoculation with bcg, immunostimulation is not significant before this sec ... | 1979 | 392421 |
| schistosomiasis: assessment of the sensitivity, specificity and reproducibility of serological methods for the diagnosis of schistosomiasis in nigeria. | three groups of sera were tested by indirect fluorescent antibody (ifa), complement fixation (cf) and counter-current immunoelectrophoresis (ccie) techniques; 56 (10.1%) of 554 sera from nigerians were anticomplementary and so could not be tested by the cf. crude antigen extract of adult schistosoma mansoni was used in the cf and ccie tests and cercarial antigen in the ifa test. ifa was the most sensitive test and cf the most specific. the reproducibility of both these tests was good. the ccie w ... | 1979 | 393189 |
| schistosoma japonicum: highly irradiated cercariae as a test for specific immunity in rhesus monkeys. | | 1977 | 408169 |
| [interaction between salmonella and schistosomes. scanning electron microscopy study]. | in our attempts to elucidate the pathogenesis of prolonged salmonella bacteremia in patients with schistosoma mansoni or schistosoma haematobium infection, we have utilised meb. our results are significant. they show an association exists between bilharziasis and salmonellosis. | 1979 | 393422 |
| the activity of a benzothiopyranoindazole (ia-4 n-oxide) against schistosoma mansoni infection in rhesus monkeys. | the prophylactic and therapeutic efficacies of ia-4 n-oxide against schistosoma mansoni in rhesus monkeys (macaca mulatta) have been evaluated. ten monkeys were divided into 5 groups of 2 monkeys each. all monkeys were exposed to s. mansoni cercariae on day 0 and treatment groups were established as follows: untreated controls, oral prophylactic administration, intramuscular prophylactic administration, oral therapeutic administration, and intramuscular therapeutic administration. analysis of pa ... | 1977 | 410318 |
| further purification and characterization of a circulating antigen in schistosomiasis. | previous studies showed that an antigen found in the circulation of animals heavily infected with schistosoma mansoni was extracted in a trichloroacetic acid soluble-chloroform insoluble fraction (tca-s-c) of adult worms. antigenic activity was destroyed by periodate treatment but remained unaltered after treatment with proteolytic enzymes, dnase, rnase, and lyophilization. in the present study, chromatography of tca-s-c on a deae cellulose column revealed six substances, one of which was antige ... | 1977 | 410879 |
| antischistosomal activity of s-2-[[2-(2-thiazolylcarbamoyl) ethyl] amino] ethyl hydrogen thiosulfate in vitro and in vivo. | | 1977 | 412938 |
| antischistosomal effects of 5-(2,4,5-trichlorophenyl)hydantoin and related compounds. | 5-(2,4,5-trichlorophenyl)hydantoin and several analogues effected an 80-90% reduction of live schistosomes in infected mice at doses ranging from 265 to 329 mg/kg per day when administered orally in the diet for 14 days. the sodium salt of 5-(2,4,5-trichlorophenyl)hydantoin, when given by gavage to rhesus monkeys infected with schistosoma mansoni at 200 mg/kg/day for 5 or 10 days, removed all but a few live worms with no evidence of intolerance. | 1977 | 412964 |
| eosinophilia following treatment of patients with schistosomiasis mansoni and bancroft's filariasis. | eosinophilia is frequently observed after treatment of patients with infections due to parasitic helminths. for definition of the characteristics and causes of post-treatment eosinophilic responses, 47 patients with bancroft's filariasis, who were treated with diethylcarbamazine, and eight patients with schistosomiasis mansoni, who were treated with niridazole, were studied. after therapy for eight days, both groups developed significant (p less than 0.05) increases in their levels of eosinophil ... | 1979 | 448186 |
| factors in the pathogenesis of acute schistosomiasis mansoni. | acute schistosomiasis mansoni was studied in 26 puerto rican patients whose clinical presentations differed widely in severity. severity of illness was found to be positively correlated (r = 0.79) with the intensity of infection as measured by the concentration of eggs of schistosoma mansoni in stool specimens. however, some patients had severe illness but relatively light infections. the disappearnace of symptoms and return toward normal of laboratory measures of disease activity were not assoc ... | 1979 | 448192 |
| eosinophilia in kenyan baboons (papio anubis) induced by trichinella spiralis and schistosoma mansoni. | high primary doses of trichinella spiralis administered orally to kenyan baboons (papio anubis) induced a marked but unpredictable eosinophilia which started 2--3 weeks after infection and persisted as erratic waves for at least 6 months. low primary oral doses induced no eosinophilia but a later, high challenge gave an accelerated eosinophilic response, although the peak was lower than in high primary infection. intravenous injection of infective t. spiralis larvae resulted in a predictable, ra ... | 1977 | 413084 |