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use of a rhesus plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances.there remains a need for new drugs to prevent relapse of plasmodium vivax or p. ovale infection. the relapsing primate malaria p. cynomolgi has been used for decades to assess drugs for anti-hypnozoite activity. after sporozoite inoculation and blood-stage cure of initial parasitemia with chloroquine, rhesus macaques were treated on subsequent relapses with chloroquine in conjunction with test regimens of approved drugs. tested drugs were selected for known liver or blood-stage activity and were ...022665596
studies of plasmodium cynomolgi in the rhesus monkey, macaca mulatta. 194621003024
asexual reproduction of plasmodium cynomolgi in rhesus monkeys. 194720283800
malaria chemotherapy; the response of sporozoite-induced infections with plasmodium cynomolgi to various antimalarial drugs. 194818934432
resistance to proguanil in a mammalian malaria parasite, plasmodium cynomolgi. 194818894194
the exoerythrocytic parasites of plasmodium cynomolgi. 194818865440
the pre-erythrocytic development of plasmodium cynomolgi and plasmodium vivax. 194818865442
tissue forms of a malaria parasite, plasmodium cynomolgi. 194818858716
demonstration of a persisting exo-erythrocytic cycle in plasmodium cynomolgi and its bearing on the production of relapses. 194818865981
malaria chemotherapy; the response of trophozoite-induced infections with plasmodium cynomolgi to various antimalarial drugs. 194818938343
development of resistance to chlorguanide (paludrine) during treatment of infections with plasmodium cynomolgi. 194918114537
exoerythrocytic stages of plasmodium cynomolgi in the macaca mulatta. 194918124332
studies on relapses in blood-induced infections from plasmodium malariae and plasmodium cynomolgi. 195014804091
morphological changes in plasmodium cynomolgi following proguanil, sulphadiazine, and mepacrine therapy. 195114855619
a strain of monkey malaria (plasmodium cynomolgi) made resistant to proguanil (paludrine). 195114855617
chemotherapeutic and other studies on the pre-erythrocytic forms of simian malaria (plasmodium cynomolgi). 195214942880
[pathological-immunity relations between parasite and host in macacus rhesus inoculated with blood infected with plasmodium cynomolgi, later splenectomized and repeatedly reinfected with homologous strain]. 195413204670
further notes on the tissue stages of plasmodium cynomolgi. 195413157157
absence of cross-immunity between plasmodium cynomolgi and plasmodium gonderi. 195513306283
additional notes on the tissue stages of plasmodium cynomolgi. 195713443015
partial inhibitory effect of plistophora culicis on the sporogonic cycle of plasmodium cynomolgi in anopheles stephensi. 195813504228
blood loss and replacement in plasmodial infections. iii. plasmodium cynomolgi, plasmodium gonderi and plasmodium knowlesi in macaca mulatta mulatta, the rhesus monkey. 196013847844
the exoerythrocytic cycle of plasmodium cynomolgi and p. cynomolgi bastianellii in the rhesus monkey. 196013697716
vivax-type malaria parasite of macaques transmissible to man.transmission of plasmodium cynomolgi bastianellii from rhesus monkeys to two human subjects by anopheles freeborni and the occurrence of attacks of malaria in two other laboratory workers not exposed to human malaria suggests the existence of an animal reservoir of infection complicating malaria control and eradication.196013821129
the transmission of plasmodium cynomolgi to man. 196113748031
transmission of the m strain of plasmodium cynomolgi to man. 196113694174
clinical and physiological responses in sporozoite-induced b strain plasmodium cynomolgi and plasmodium vivax infections in normal volunteers. 196213927674
man to man transfer of two strains of plasmodium cynomolgi by mosquito bite. 196213880974
effect of certain drugs on exoerythrocytic parasites of plasmodium cynomolgi. 196213891113
the suceptibility of malayan anophelines to plasmodium cynomolgi bastianellii. 196314274297
malaria in man. infection by plasmodium vivax and the b strain of plasmodium cynomolgi. 196313927675
the activity of a repository form of 4,6-diamino-1(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine against infections with plasmodium cynomolgi. 196314044759
the localization of infective pre-erythrocytic forms of plasmodium cynomolgi. 196414128583
potentiation of activity of diaphenylsulfone and pyrimethamine against plasmodium gallinaceum and plasmodium cynomolgi bastianellii.in view of the fact that diaphenylsulfone has been shown to have low schizontocidal activity against plasmodium gallinaceum and to lead to resistance in strains of p. cynomolgi, investigations were undertaken into the joint action of diaphenylsulfone and pyrimethamine against p. gallinaceum in chicks and p. cynomolgi bastianellii in monkeys. these drugs were assayed separately and in various combinations. it was found that at certain dose levels combination of the two drugs led to potentiation o ...196414278006
transmission of a new strain of plasmodium cynomolgi to man. 196514259487
[the use of plasmodium cynomolgi bastianellii in serodiagnosis, by means of immune-fluorescence, of human malaria]. 19655334893
biology of the simian malarias of southeast asia. ii. the susceptibility of some malaysian mosquitoes to infection with five strains of plasmodium cynomolgi. 19665969101
immune response of man to inoculation with plasmodium cynomolgi and challenge with p. vivax. 19664161488
biology of the simian malarias of southeast asia. 3. sporogony of the cambodian strain of plasmodium cynomolgi. 19664381840
biology of the simian malarias of southeast asia. iv. sporogony of four strains of plasmodium cynomolgi. 19664381841
[cross serological reactions between plasmodium falciparum and plasmodium cynomolgi bastianellii. application to the serodiagnosis, by immunofluorescence, of human plasmodium falciparum malaria]. 19664860834
fluorescent-antibody studies on simian malaria. ii. development of antibodies to plasmodium cynomolgi. 19674960704
antimalarial activity of tetrahydrohomopteroic acid.tetrahydrohomopteroic acid, an analog of tetrahydrofolic acid, shows antimalarial activity against plasmodium cynomolgi and a pyrimethamine-resistant variant of this organism.19674960875
[susceptibility of various anopheles species to the pathogenic agent of simian malaria, plasmodium cynomolgi bastinelli]. 19684386476
[comparative studies of the development of plasmodium cynomolgi bastianellii in anopheles stephensi and a. albimanus]. 19685715367
activities of trimethoprim against infections with pyrimethamine susceptible and resistant strains of plasmodium cynomolgi. 19694976952
immunological studies with simian malarias. i. antigenic variants of plasmodium cynomolgi bastianellii. 19694978046
increased virulence of plasmodium cynomolgi bastianellii in the rhesus monkey. 19694978542
activity of chlorinated lincomycin analogues against plasmodium cynomolgi in rhesus monkeys. 19694978594
[studies on immunity and serological reactions in monkeys after infection with plasmodium cynomolgi bastianelli]. 19704990718
plasmodium cynomolgi: sources of variation in susceptibility of anopheles quadrimaculatus, a. balabacensis, and a. stephensi. 19705413008
a note on the effects of antimalarial drugs on the sporogonous cycle of plasmodium cynomolgi in anopheles stephensi. 19705483911
plasmodium cynomolgi: x-irradiation and development of exo-erythrocytic schizonts in macaca mulatta. 19705499672
fine structure of the exoerythrocytic stage of plasmodium cynomolgi.the light microscopy of primate exoerythrocytic stages (liver stage) of malaria is well described. this report demonstrates the ultrastructure of the 7-day exoerythrocytic stage of plasmodium cynomolgi in the liver of a rhesus monkey.19704990053
morphological characteristics of the sporogonous cycle of plasmodium cynomolgi in anopheles stephensi. 19704904946
the activities of chlorinated lincomycin derivatives against infections with plasmodium cynomolgi in macaca mulatta. 19704984584
transformation of the plasmodium cynomolgi oocyst. 19715547075
the action of 'terramycin' on the primary exoerythrocytic development of plasmodium vivax and plasmodium cynomolgi ceylonensis. 19714993964
[the evolution of fluorescent antibodies in monkeys in the course of an experimental infection with plasmodium cynomolgi bastianellii]. 19715005960
destruction of erythrocytes in monkeys (macaca mulatta) infected with plasmodium cynomolgi. 19724621818
immunization of monkeys against plasmodium cynomolgi by x-irradiated sporozoites. 19724624244
studies on the transmission of simian malaria. v. infection and transmission of the b strain of plasmodium cynomolgi. 19724626891
studies on the prophylactic and radical curative activity of rc-12 against plasmodium cynomolgi in macaca mulatta.the compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (rc-12) has been shown to be active against the exoerythrocytic (ee) stages of the malaria parasite. experiments on plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of ee stages. the usefulness of rc-12 for effecting radical cures is, however, still open to doubt.19724631044
accidental human infection with plasmodium cynomolgi bastianellii. 19734207080
detection of early exoerythrocytic schizonts of plasmodium cynomolgi by immunofluorescence. 19734123941
gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. i. effect of single and multiple doses of primaquine on plasmodium cynomolgi. 19734200769
letter: the antimalarial activity of rc-12 against gametocytes and sporogony of plasmodium cynomolgi. 19734204929
plasmodium cynomolgi malaria: accidental human infection. 19734631763
plasmodium cynomolgi: the comparative infectiousness of individual rhesus monkeys. 19734632461
studies on the antimalarial effects of rc-12 and wr 14,997 on the development of plasmodium cynomolgi in mosquitoes and rhesus monkeys. 19744207342
plasmodium cynomolgi: influence of x-irradiation and sporozoite dilution on relapse patterns in infected rhesus monkeys. 19744206933
gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. ii. action of the folic reductase inhibitors, chlorguanide, and pyrimethamine against plasmodium cynomolgi. 19744413531
incorporation of nucleic acid precursors by plasmodium cynomolgi in anopheles balabacensis.autoradiography was used to study the incorporation of tritium-labelled nucleic acid precursors into the sporogonic stages of plasmodium cynomolgi in anopheles b. balabacensis. infected mosquitoes were fed on either 3h-adenine (5, 25 and 50 muci/ml or 3h-thymidine (50 muci/ml) for various periods after the blood meal. 3h-adenine was incorporated into dna and rna of the developing oocysts and the resulting sporozoites. midgut epithelial cells incorporated label from 3h-adenine into nuclear and cy ...19751189024
transmission of plasmodium cynomolgi to aotus trivirgatus monkeys. 1975804032
5-aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials.5-(p-anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the plasmodium berghei and monkey prophylactic (plasmodium cynomolgi) tests. a new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. none of these compounds showed significant antimalarial or prophylactic activity.1976824437
evaluating new antimalarial drugs against trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys.an antimalarial drug testing system is described which utilizes trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys. the schizonticidal activity of standard antimalarial drugs in this system is reported. the system accurately predicted antimalarial activity in man of 8 of 9 compounds selected for clinical trials.1976816211
reduced 8-aminoquinoline analogues as potential antimalarial agents.the synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-n,n-diethylaminoethyl)-8-(2-n,n-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline, and 2-substit ...1976824447
radical cure of infections with plasmodium cynomolgi: a function of total 8-aminoquinoline dose. 1977413444
quantitative aspects of pyrimethamine-sulfonamide synergism.the experiments described in this report have dealt with the dimensions of therapeutic potentiation achieved when combinations of pyrimethamine and sulfadiazine were administered to rhesus monkeys infected with a drug-susceptible strain of plasmodium cynomolgi or its pyrimethamine-resistant variant and to owl monkeys infected with strains of p. falciparum and p. vivax of varying degrees of resistance to this pyrimidine. these evaluations showed: 1) that when delivered in combination, the activit ...1977410317
synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials.a series of 2-benzyloxy and 2-benzylthio analogues of primaquine has been synthesized and evaluated against plasmodium berghei in the mouse and plasmodium cynomolgi in the rhesus monkey. 8-aminoquinoline toxicity, as measured in the rane mouse screen, was reduced, and these compounds showed significant blood schizonticidal antimalarial activity in mice. in monkeys, significant tissue-schizonticidal activity was observed.1977409843
comparison of the curative antimalarial activities and toxicities of primaquine and its d and l isomers.this investigation was undertaken to determine whether either d-primaquine or l-primaquine has sufficient advantage over primaquine to warrant evaluation for curative activity in human volunteers infected with plasmodium vivax. it was found: (i) that the capacities of the isomers and the racemate to cure infections with plasmodium cynomolgi in rhesus monkeys were essentially identical; (ii) that the subacute toxicities of the isomers and racemate for this monkey were qualitatively the same, but ...1977407841
the characteristics of plasmodium cynomolgi infections in various old world primates. 1977405875
plasmodium cynomolgi: effects of malaria infection on laboratory flight performance of anopheles stephensi mosquitoes. 1977403087
antimalarials. 10. synthesis of 4-substituted primaquine analogues as candidate antimalarials.primaquine (i) has been extensively used in combination with other drugs in the radical cure of relapsing malaria as well as for prophylaxis or the interruption of transmission. this, coupled with the activity data reported for 4-methylprimaquine (ii), has led to the synthesis of a series of 14 4-substituted analogues of i. in addition, three side-chain analogues of ii were prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in the rane mouse scre ...1977411930
synthesis of 2-substituted primaquine analogues as potential antimalarials.a series of 2-substituted primaquine analogues has been synthesized and evaluated against plasmodium berghei in the mouse and leishmania donovani in the hamster. three members (3a,d,e) of the series were evaluated against plasmodium cynomolgi in the rhesus monkey. one analogue (3d) was evaluated against trypanosoma rhodesiense in the mouse, and two (3b,e) were evaluated against schistosoma mansoni in the mouse. several analogues possessed significant activity against p. berghei (3e,f) and l. don ...1978102798
sporozoites of rodent and simian malaria, purified by anion exchangers, retain their immunogenicity and infectivity.sporozoites of rodent malaria, plasmodium berghei, and simian malaria, plasmodium knowlesi and plasmodium cynomolgi, were partially separated from mosquito debris and microbial contaminants by passage of anopheles material through a deae-cellulose column. in addition to eliminating most of the contaminants (80-90%), this simple technic has made it possible to recover rapidly large numbers of viable sporozoites (55-75% yield), which have retained their infectivity, immunogenicity, and capacity to ...1978351177
resolution of antimalarial agents via complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid.the resolution of several antimalarial agents via pi-complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid (tapa) is reported. since this represents the first use of this agent for the resolution of amines, some details of the separations are presented. the method proved successful for resolving weakly alkaline amines that did not form stable salts with common resolving acids, highly insoluble amines that did not form soluble salts with usual resolving acids, ...1978349156
primaquine analogues: derivatives of 4-amino-2-methoxyacridine.based on the antimalarial activity of primaquine (1a) and its 4-methyl analogue 1b, 4-aminoacridinyl analogues, 4-[(4-amino-1-methylbutyl)amino]-2-methoxyacridine (2a) and 4-[(4-amino-1-methylbutyl)amino]-2-methoxy-9-methylacridine (2b), were prepared and evaluated as potential tissue schizonticidal agents. these compounds were found to be substantially less active than primaquine against plasmodium cynomolgi in the rhesus monkey. the antileishmanial activity in hamsters of 4-[[6-(diethylamino)h ...1979117105
studies on the 2,4-diamino-6 substituted quinazolines. i. antimalarial activities of 2,4-diamino-6-[(3,4-dichlorobenzyl)-nitrosoamino]-quinazoline (ci-679) as exhibited in rhesus monkeys infected with the ro or ro/pm strains of plasmodium cynomolgi.this report summarizes the results of appraisals of various activities of ci-679 (a 2,4-diamino-6-amino-substituted quinazoline) in rhesus monkeys infected with the ro and ro/pm strains of plasmodium cynomolgi. in subjects inoculated with sporozoites, ci-679, administered in appropriate schedules in doses up to and including the maximum tolerated level, neither prevented development of infections with these strains nor cured those already established. although these evaluations showed that ci-67 ...1979114064
enhancement of a simian malarial infection (plasmodium cynomolgi) in mosquitoes fed on rhesus (macaca mulatta) previously infected with an unrelated malaria (plasmodium knowlesi). 1979111568
freeze-fracture study of malaria sporozoites: antibody-induced changes of the pellicular membrane.plasmodium cynomolgi, plasmodium knowlesi, and plasmodium berghei sporozoites, before and after incubation with immune serum, were studied after freeze-fracture by electron microscopy. there were evenly distributed numerous intramembranous particles (imp) on the p face of the outer membrane. the e face of the plasma membrane had fewer imp than its p face. the e face of the intermediate membrane had few imp and also linear arrays of slightly raised ridges running the length of the parasite. the p ...1979385856
[two accidental human infections by plasmodium cynomolgi bastianellii. a clinical and serological study]. 19807016051
plasmodium cynomolgi: folic acid antagonist combinations for treatment of malaria in rhesus monkeys. 19806767622
synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics.a series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against plasmodium berghei in mice and leishmania donovani in hamsters. 8-[[6-(diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against l. donovani. 2-ethyl-4-methylprimaquine (7a) was evaluated against plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine.19806770089
synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines.three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. it also possessed outstanding causal prophylactic activity against plasmodium cynomolgi in rhesus monkeys at very low dosages.19817205891
comparative efficacies of quinine and chloroquine as companions to primaquine in a curative drug regimen.a comparison has been made of the capacities of chloroquine and quinine to serve as companions to primaquine in curing established infections with sporozoites of the m or b strains of plasmodium cynomolgi in rhesus monkeys. the results indicated that chloroquine was slightly but consistently more effective than quinine in this role. this finding provides support for use of chloroquine as the companion blood schizonticide in the current experimental animal-based search for improved tissue schizon ...19817212167
cultivation in vitro of the vivax-type malaria parasite plasmodium cynomolgi.the vivax-type simian malaria parasite plasmodium cynomologi was cultured in vitro by both the candle jar method and the continuous flow technique, with rhesus monkey erythrocytes and rpmi 1640 medium supplemented with hepes buffer and human serum. after 6 weeks in culture, the growth of the parasite had permitted a 5 x 10(6) cumulative dilution of the original inoculum. cultured parasites remained infective to rhesus monkeys and exhibited a reversible decrease in the ameboid behavior of their t ...19817233207
the 48-hour exoerythrocytic stage of plasmodium cynomolgi bastianellii.detection and specific identification of the 48-hour exoerythrocytic stage of the primate malaria parasite, plasmodium cynomolgi bastianellii, was accomplished by means of a highly specific indirect immunofluorescence technique (ifa) applied to hepatic tissue fixed in carnoy's solution. the 48-hour forms appeared as round-to-slightly-oval bodies of average mean diameter 3.0 micrometers (9 parasites) and lying with the cytoplasm of individual hepatic parenchymal cells; each possessed one to three ...19817011070
presbytis entellus and macaca radiata as new hosts for experimental plasmodium cynomolgi bastianellii infection. 19827174004
plasmodium cynomolgi infections in the rhesus monkey. 19827081552
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