Publications

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the genetic analysis of resistance to benomyl in neurospora crassa. 19744279980
slow conformational changes of a neurospora glutamate dehydrogenase studied by protein fluorescence.1. the nadp-dependent glutamate dehydrogenase of neurospora crassa undergoes slow reversible structural transitions, with half-times in the order of a few minutes, between active and inactive states. the inactive state of the enzyme, which predominates at ph values below 7.0, has an intrinsic tryptophan fluorescence 25% lower than that of the active state, which predominates at ph values above 7.6. the inactive state can be activated either by an increase in ph or by addition of activators such ...19744156826
protease secretion in neurospora crassa. 19744278579
proceedings: precursors of cytochrome oxidase in cytochrome-oxidase deficient cells of neurospora crassa. 19744376789
the effect of chloramphenicol on mitochondrial protein synthesis in neurospora crassa. 19744283464
proceedings: identification of two products of mitochondrial protein synthesis associated with oligomycin-sensitive atpase from neurospora crassa. 19744282372
phase-specific genes for macroconidiation in neurospora crassa.two new mutant genes in neurospora crassa prevent the formation of free macroconidia from proconidial chains. these genes, called conidial separation-1 and conidial separation-2, are phase-specific, playing no role in either the sexual life cycle or other aspects of the asexual life cycle. a cell-wall-associated autolytic activity was found to increase in wild-type cultures at the time of active formation of free conidia from proconidial chains; no such increase was detected in mutant cultures. ...19744280981
regulation of phosphate metabolism in neurospora crassa: isolation of mutants deficient in ther repressible alkaline phosphatase.mutants of neurospora crassa have been isolated that lack the repressible alkaline phosphatase, but, unlike nuc-1 and nuc-2 mutants, are able to make the repressible acid phosphatase and the repressible phosphate permease under conditions of derepression (phosphate deprivation). the new mutants, called pho-2, map in linkage group v, and are unlinked to the putative control mutants, nuc-1, nuc-2-pcon(c), and preg(c). three of the pho-2 mutants do not make detectable amounts of repressible alkalin ...19744280980
a second locus subject ot recombination control by the rec-1+ gene in neurospora crassa. 19744280900
an improved method for the production of neurospora crassa spheroplasts and a new method for measuring transport in fragile cells. 19744278825
sterols of neurospora crassa and the pattern of their binding during the growth cycle. 19744278288
cross-pathway regulation: tryptophan-mediated control of histidine and arginine biosynthetic enzymes in neurospora crassa.in neurospora crassa, the starvation of tryptophan mutants for tryptophan resulted in the derepression of tryptophan, histidine, and arginine biosynthetic enzymes. this tryptophan-mediated derepression of histidine and arginine biosynthetic enzymes occurred despite the fact that the tryptophan-starved cells had a higher intracellular concentration of histidine and arginine than did nonstarved cells.19744368541
cross-pathway regulation: histidine-mediated control of histidine, tryptophan, and arginine biosynthetic enzymes in neurospora crassa.in neurospora crassa, histidine starvation of histidine mutants resulted in derepression of histidine, tryptophan, and arginine biosynthetic enzymes. the same tripartite derepression occurred in wild-type strain 74a when it was grown in medium supplemented with 3-amino-1,2,4-triazole, an inhibitor of histidine biosynthesis. histidine-mediated derepression of tryptophan and arginine biosynthetic enzymes was not due to a lowered intracellular concentration of tryptophan or arginine, respectively. ...19744368540
specific fragmentation of adenovirus heteroduplex dna molecules with single-strand specific nucleases of neurospora crassa. 19744280445
control of the flux to arginine in neurospora crassa: de-repression of the last three enzymes of the arginine pathway. 19744279299
the effect of temperature on photo-induced carotenoid biosynthesis in neurospora crassa.the temperature dependence of carotenoid synthesis in neurospora crassa was investigated. the primary light reaction is independent of temperature, but the amount of carotenoid pigment which subsequently accumulates in the dark is strongly dependent on the temperature during the dark incubation. carotenoid synthesis shows a sensitivity to both high and low temperatures, and of the temperatures tested, 6 c is optimal. exposure to temperatures above 6 c for various times immediately following irra ...197416658849
revertants and secondary arom-2 mutants induced in non-complementing mutants in the arom gene cluster of neurospora crassa.extensive genetical and biochemical studies have been performed with revertants and secondary arom-2 mutants induced in two different primary non-complementing mutants which map within the arom gene cluster of neurospora crassa. these studies indicate that mutant m54 but not m25 can revert by super-suppressor mutations in unlinked genes, thus confirming previous evidence that m54 contains a nonsense codon. at least three new super suppressors of m54 have been detected. all four super suppressors ...19744371577
a genetic study of female sterility in neurospora crassa. 19744279838
mutagenicity of ddt in mice, drosophila melanogaster and neurospora crassa. 19744279650
mutants of neurospora crassa resistant to 8-azaguanine. 19744279275
regulation of sulfate metabolism in neurospora crassa: transport and accumulation of glucose 6-sulfate. 19744278785
isolation and properties of selenomethionine-resistant mutants of neurospora crassa.mutants resistant to selenomethionine were isolated, and their properties studied. mapping studies indicate that the mutation sites are located near the eth-1(r) locus in linkage group i, about ten map units away from the mating type locus. the sites of new mutation are either allelic to or very close to eth-1(r). they are resistant not only to selenomethionine but also to ethionine, while the ethionine-resistant mutant, eth-1(r), is sensitive to selenomethionine. the selenomethionine-resistant ...19744278470
peptide utilization by amino acid auxotrophs of neurospora crassa.the ability of auxotrophs of neurospora crassa to grow on certain tripeptides, despite the presence of excess competing amino acids, suggests it has an oligopeptide transport system. in general, dipeptides did not support growth except in those instances where extracellular hydrolysis occurred, or where the dipeptide appeared to be accumulated by an uptake system which is sensitive to inhibition by free amino acids. considerable intracellular peptidase activity toward a large number of peptides ...19744277602
proteinaceous hexagonal inclusions in hyphae of whetzelinia sclerotiorum and neurospora crassa. 19744366209
growth, respiratory, and cytochrome characteristics of certain of the isoleucine-valine mutants of neurospora crassa. 19744279658
role of a mitochondrial gene in the conformation and optical properties of mitochondrial cytochromes in neurospora crassa. 19744279657
relationship between (8-14c)adenosine transport and growth inhibition in neurospora crassa strain ad-8.the kinetic parameters of [8-(14)c]adenosine transport by a general nucleoside uptake system were studied in germinated conidia of the ad 8 strain of neurospora crassa. the apparent k(m) for adenosine uptake by this system was found to be 6.2 mum. the apparent k(i) values for other nucleosides competing with adenosine for uptake were measured by using dixon plots. nucleosides which were efficient competitive inhibitors of adenosine transport were found to inhibit severely the rate of growth of s ...19744276058
a neurospora crassa morphological mutant showing reduced adenylate cyclase activity. 19744365561
the isolation and partial characterization of two novel sphingolipids from neurospora crassa: di(inositolphosphoryl)ceramide and ((gal)3glu)ceramide. 19744364652
induction of cyanide-insensitive respiration in neurospora crassa. 19744275427
a direct comparison between circadian and noncircadian rhythms in neurospora crassa.a method has been devised for observing both circadian and noncircadian rhythms in a single wild type strain of neurospora crassa. this method allows a direct comparison of the properties of the two types of rhythm. the circadian rhythm of conidiation always entrains to a light-dark cycle, damps out in constant light, and has a temperature-compensated period length. the noncircadian rhythm of hyphal branching, expressed by the same strain under different environmental conditions, does not entrai ...197416658817
occurrence of n-formylkynurenine in extracts of neurospora crassa: evidence for the activity of tryptophan pyrrolase.n-formylkynurenine and kynurenine have been detected in extracts of tryptophan-grown neurospora crassa. when the mycelia were grown in medium supplemented with l-[2-(14)c]tryptophan, the radioactivity was detected in n-formylkynurenine and n-formylanthranilic acid; with l-[beta-(14)c]tryptophan, radioactivity was detected in n-formylkynurenine, kynurenine, kynurenic acid, and xanthurenic acid. the occurrence of n-formylkynurenine in extracts of tryptophan-grown neurospora is interpreted as direc ...19744275312
artificial induction of the sexual cycle of neurospora crassa. 19744276299
purification and properties of the nitrate reductase isolated from neurospora crassa mutant nit-3. kinetics, molecular weight determination, and cytochrome involvement. 19744275465
the mitochondrial beta-cytochromes of the wild type and poky strains of neurospora crassa. evidence for a component reduced only by dithionite. 19744275176
photoreceptor pigment for blue light responses in neurospora crassa. 19744275420
depolarization of the plasma membrane of neurospora during active transport of glucose: evidence for a proton-dependent cotransport system.intracellular microelectrodes were used to measure the effects of glucose transport on membrane voltage and membrane resistance in neurospora crassa. sudden activation of glucose uptake, via the high-affinity, derepressible system ii, results in a very large depolarization of the plasma membrane. at saturating concentrations of glucose, the depolarization averages 120 mv; it is diphasic in time, with an initial shift at rates of 100-200 mv/sec followed by a slow, spontaneous, partial repolarizat ...19744525303
3-hydroxy-3-methylglutaryl coa reductase and mevalonate kinase of neurospora crassa.two enzymes of polyisoprenoid synthesis, 3-hydroxy-3-methylglutaryl coenzyme a (hmg coa) reductase (mevalonate:nadp oxidoreductase [acylating coa], ec 1.1.1.34) and mevalonate kinase (atp:mevalonate 5-phosphotransferase, ec 2.7.1.36), are present in the microsomal and soluble fractions of neurospora crassa, respectively. hmg coa reductase specifically uses nadph as reductant and has a k(m) for dl-hmg coa of 30 micro m. the activities of hmg coa reductase and mevalonate kinase are low in conidia ...19744363966
neurospora crassa protein kinase. purification, properties, and kinetic mechanism. 19744362679
the cytidine mechanism and methylation pathway in the formation of n-methylated ethanolamine phosphoglycerides in neurospora crassa. 19744364967
the efficacy of various mutagens and polyene antibiotics for the induction and isolation of sterol mutants of neurospora crassa. 19744366322
neurospora crassa glucogen phosphorylase: interconversion and kinetic properties of the "active" form. 19744275853
developmental regulation of choline sulfatase and aryl sulfatase in neurospora crassa. 19744275662
temperature-sensitive pleiotropic revertants from a mutant in the arom gene cluster of neurospora crassa.genetical and biochemical studies have been performed with revertants induced in a polyaromatic mutant (no. 58) in the arom gene cluster of neurospora crassa. in addition to complete and partial revertants able to grow on minimal at both 25 degrees and 35 degrees , temperature-sensitive revertants capable of growth on minimal at 25 degrees but not at 35 degrees have been recovered. one of these revertants has been shown to lack biosynthetic dehydroquinase activity at both temperatures (utilizing ...19744365170
a histidine-3 mutant, in neurospora crassa, due to an interchange. 19744277978
the inducible quinate-shikimate catabolic pathway in neurospora crassa: induction and regulation of enzyme synthesis. 19744275849
a selective technique for the isolation of neurospora crassa from soil. 19744275709
the inducible quinate-shikimate catabolic pathway in neurospora crassa: genetic organization. 19744275708
uptake of nitrite by neurospora crassa.like the nitrate transport system, the nitrite uptake system in neurospora crassa is induced by either nitrate or nitrite. this induction is prevented by cycloheximide, puromycin, or 6-methyl purine. the k(m) for nitrite of the induced nitrite uptake system is 86 mum, and the v(max) is 100 mumol of nitrite per g (wet weight) per h. nitrite uptake is inhibited by metabolic poisons such as arsenate, dinitrophenol, cyanide, and antimycin a. no repression or inhibition of the nitrite transport syste ...19744274458
nitrate transport system in neurospora crassa.nitrate uptake in neurospora crassa has been investigated under various conditions of nitrogen nutrition by measuring the rate of disappearance of nitrate from the medium and by determining mycelial nitrate accumulation. the nitrate transport system is induced by either nitrate or nitrite, but is not present in mycelia grown on ammonia or casamino acids. the appearance of nitrate uptake activity is prevented by cycloheximide, puromycin, or 6-methyl purine. the induced nitrate transport system di ...19744274457
uptake and efflux of sulfate in neurospora crassa. 19744276129
a study of l-glutamine: d-fructose 6-phosphate amidotransferase in certain developmental mutants of neurospora crassa. 19744275871
the biogenesis of mitochondria in neurospora crassa: ultrastructural changes induced by nutrients. 19744365709
mitochondrial translation of cytochrome b in neurospora crassa and locusta migratoria. 19744279883
lipid composition of mitochondrial outer and inner membranes of neurospora crassa. 19744279881
amino acid transport during development of neurospora crassa conidia: substrate repression. 19744275410
circadian rhythms of nucleic acid metabolism in neurospora crassa.wild-type, band, and fluffy strains of neurospora crassa exhibit circadian rhythms of ribonucleic acid and deoxyribonucleic acid content in the growth-front hyphae of cultures grown on a solid medium. there is also a rhythm of (3)h-uridine incorporation into the nucleic acids of the band strain. maximum incorporation precedes the peaks of nucleic acid content which occur during conidiation. as cultures age, ribonucleic acid content decreases rapidly and deoxyribonucleic acid content decreases gr ...19744273317
isolation and characterization of low-kynureninase mutants of neurospora crassa.two kynureninase activities are known in neurospora crassa, one of which (kynureninase i) is inducible, the other (kynureninase ii) being constitutive. a method is described for the isolation of low-kynureninase mutants of n. crassa. when grown on an inducer, the mutants show significantly less kynureninase i activity compared with wild type, whereas constitutive kynureninase ii activity is unaffected. since a low level of kynureninase i activity remains in the mutants examined, the mutations ma ...19744273316
methylation and processing of mitochondrial ribosomal rnas in poky and wild-type neurospora crassa. 19744274511
conidiation of neurospora crassa in submerged culture without mycelial phase. 19744275899
a failure to detect an influence of magnetic fields on the growth rate and circadian rhythm of neurospora crassa.low strength magnetic fields, 6.36 and 32.25 gauss, were found to have no effect, with one questionable exception, on the circadian rhythm and growth rate of neurospora crassa. this was true whether the fields were continuous, pulsed 20 minutes daily, or on a 12: 12, on-off cycle.197416658667
studies of respiratory components and oxidative phosphorylation in mitochondria of mi-1 neurospora crassa.oxidative phosphorylation has been demonstrated with mitochondria of the mi-1 respiratory mutant of neurospora crassa. the p/o ratios observed with these mitochondria were approximately 0.8 with citrate and 0.4 with either externally added reduced nicotinamide adenine dinucleotide (nadh), succinate, or ascorbate-tetramethyl-p-phenylenediamine (tpd). these p/o ratios suggest that there are only two sites of phosphorylation in mitochondria isolated from young (20 to 24 h) cultures of the mi-1 muta ...19744359654
ethylene glycol-induced alteration of conidial germination in neurospora crassa.in nutrient medium containing 3.22 m ethylene glycol or glycerol, conidia of neurospora crassa grow as single cells, without forming the germ tubes characteristic of normal morphological germination. ethylene glycol is more effective than glycerol in producing this response. after growth in ethylene glycol medium for a suitable time, the cells are easily disrupted by an abrupt decrease in osmotic pressure. osmotic disruption yields intact nuclei and mitochondria, although mitochondrial fractions ...19744359649
rna polymerase activities in neurospora crassa. 19744277640
effects of ultraviolet radiation on carotenoid-containing and albino strains of neurospora crassa. 19744276420
hyphal tips of wild-type and spreading colonial mutants of neurospora crassa. 19744372967
membrane permeability and the loss of germination factor from neurospora crassa at low water activities.neurospora crassa conidia incubating in buffer at low water activities (a(w)) release a germination-essential component as well as 260-nm absorbing and ninhydrin-positive materials, regardless of whether an electrolyte or non-electrolyte is used to reduce a(w). chloroform and antibiotics known to increase cell-membrane permeability have a similar effect. this suggests that membrane damage occurs in media of low a(w) and that an increase in permeability is responsible for the release of cellular ...19744358044
nucleotide degrading enzymes in neurospora crassa. 19744282658
genetic contro of recombination in neurospora crassa. ii. polygenic and maternal control in two promimal chromosome regions - a quantitative analysis. 19744282487
hyperproduction of some glycosidases in neurospora crassa. 19744281648
metabolic products of microorganisms. 135. uptake of iron by neurospora crassa. iv. iron transport properties of semisynthetic coprogen derivatives. 19744281294
sporopollenin formation in the ascospore wall of neurospora crassa. 19744280888
induction and genetical analysis of edeine resistant mutants of neurospora crassa. 19744280502
a perithecial color mutant of neurospora crassa. 19744277338
[derepression and conidiation in a neurospora crassa mutant (acu-3) nonutilizing acetate]. 19744276450
quantitative assay of pyrazofurin, a new antiviral, antitumor antibiotic.pyrazofurin, a carbon-linked nucleoside, has been previously reported to possess antiviral and antitumor activity. the antagonistic effect of pyrazofurin against neurospora crassa has been utilized to develop a quantitative assay for the compound.19744275616
occlusion of the septal pores of damaged hyphae of neurospora crassa by hexagonal crystals. 19744275239
a quantitative estimate of dna-rna hybridization in neurospora crassa. 19744274642
control of transcription in neurospora crassa. 19744274640
polysomes, ribonucleic acid, and protein synthesis during germination of neurospora crassa conidia.the level of polysomes in ungerminated conidia of neurospora crassa depends on the method used to collect spores. spores harvested and exposed to hydration contain 30% of their ribosomes as polysomes, whereas those not exposed to hydration contain only 3% of their ribosomes as polysomes. during the germination process, the percentage of the ribosomes which sediment as polysomes increases rapidly to a level of approximately 75% during the first 15 to 30 min of germination. this rapid increase has ...19744271808
purine and pyrimidine biosynthesis in neurospora crassa and human skin fibroblasts. alteration by ribosides and ribotides of allopurinol and oxipurinol. 19744275559
metabolic products of microorganisms. 132. uptake of iron by neurospora crassa. 3. iron transport studies with ferrichrome-type compounds. 19744275989
properties of repressible alkaline phosphates from wild type and a wall-less mutant of neurospora crassa. 19744276965
immunological difference of mitochondrial and cytoplasmic ribosomes of neurospora crassa. 19744277526
isocitrate lyase from neurospora crassa. i. purification, kinetic mechanism, and interaction with inhibitors. 19744278771
isocitrate lyase from neurospora crassa. ii. composition, quaternary structure, c-terminus, and active-site modification. 19744278772
translation products in vitro of mitochondrial messenger rna from neurospora crassa. 19744279820
the modifying effects of strain and age on the mutagenic specificity of ultraviolet light in neurospora crassa.two derivatives of k3/17 ad-3a 38701; inos 37401 of neurospora crassa are described which show opposite specific reversional responses to uv. both derivatives carry the same two auxotrophic alleles and appear to differ only in a single gene which influences the pattern of mutagen specificity. the differences between the derivatives only develop after the cultures have been aged for two to four weeks. various possible explanations are considered.19744282639
mutagenic and recombinogenic activities of the food additive furylfuramide in eurkaryotes.the mutagenic and recombinogenic activities of furylfuramide, an antimicrobial food additive, were tested in a two-component heterokaryon of neurospora crassa and a diploid strain of saccharomyces cerevisiae, respectively. the results show that furylfuramide is genetically active in both eukaryotic organisms; it induces mutations in neurospora crassa and mitotic crossing over in saccharomyces cerevisiae.19744283384
neurospora crassa and humicola lanuginosa cytochromes c: more homology in the heme region. 19744363050
[griseocarnin, an antifungal antibiotic isolated from streptoverticillium criseocarneum (ia-7527)].we have been studying the antagonistic activity of the streptoverticillium griseocarneum, strain ia-7527. it produces a strong antifungal substance which we named griseocarnin. its antimicrobial power to neurospora crassa, rhodotorula, rubra, hansenula suaveolens and candida albicans deserves to be exceled. the isolated substance was compared with other antifungal antibiotics presenting close similarity with the heptaens ascosin and pa-150. the production, extraction and purification methods as ...19744220132
amino-acid sequence of nadp-specific glutamate dehydrogenase of neurospora crassa.a tentative primary structure of the nadp-specific glutamate dehydrogenase [l-glutamate: nadp oxidoreductase (deaminating), ec 1.4.1.4] from neurospora crassa has been determined. the proposed sequence contains 452 amino-acid residues in each of the identical subunits of the hexameric enzyme. comparison of the sequence with that of the bovine liver enzyme reveals considerable homology in the amino-terminal portion of the chain, including the vicinity of the reactive lysine, with only shorter str ...19744155068
a nuclease from neurospora crassa specific for d(a-t) rich regions in double stranded dna.a nuclease from n. crassa has been prepared to the hydroxylapatite stage of purification described by rabin and fraser (1). it degrades single stranded dna in an essentially exonucleolytic process. it does not give any appreciable acid soluble material with double stranded dna as substrate. this shows its high degree of specificity towards single stranded dna. an extra activity which makes double strand breaks in the at rich regions of dna is described. a limited number of breaks are observed wi ...197410793677
isolation of repeated and self-complementary sequences from e. coli dna.we have used the single-strand specific nuclease from neurospora crassa and chromatography on methylated albumin-kieselguhr to purify and characterize repeated and self-complementary sequences from escherichia coli dna. approximately 0.5% of the genome renatures spontaneously at zero time and another 2% renatures somewhat more rapidly than the total dna. the early renaturing dna has a base composition and a tm similar to the total dna and contains on the average 100 base pairs; the self-compleme ...197410793709
the amino acid sequence of neurospora nadp-specific glutamate dehydrogenase. peptides from digestion with a staphylococcal proteinase.the extracellular proteinase of staphylococcus aureus strain v8 was used to digest the nadp-specific glutamate dehydrogenase of neurospora crassa. of 35 non-overlapping peptides expected from the glutamate content of the polypeptide chain, 29 were isolated and substantially sequenced. the sequences obtained were valuable in providing overlaps for the alignment of about two-thirds of the sequences found in tryptic peptides wootton, j. c., taylor, j, g., jackson, a. a., chambers, g. k. & fincham, ...19751001
mutagenicity of actinomycin d in neurospora crassa.actinomycin d is known to bind to native dna and is widely used as an antineoplastic agent and inhibitor of dna-dependent rna and protein synthesis. we report here the induction by actinomycin d of purple adenine-requiring mutants (ad-3) in wild-type neurospora crassa. a significant increase in the frequency of ad-3 mutants was evident when the organism was grown vegetatively in the presence of actinomycin d; the mutation frequency was at least 3.6 per 106 survivors. the actinomycin d-induced ad ...197555964
genetic characterization of adenine-3 mutants induced by 4-nitroquinoline 1-oxide and 4-hydroxyaminoquinoline 1-oxide in neurospora crassa.specific locus mutations induced by the chemical carcinogens, 4-nitroquinoline 1-oxide (4nqo) and 4-hydroxyaminoquinoline 1-oxide (4haqo), have been characterized to obtain a presumptive identification of the genetic alterations at the molecular level. one hundred eighty-four 4nqo-induced and 219 4haqo-induced ad-3 mutants of neurospora crassa obtained in previous studies were studied with a series of genetic tests that permits determination of their genotype and the frequencies of point mutatio ...1975122814
in vitro restoration of nitrate reductase: investigation of aspergillus nidulans and neurospora crassa nitrate reductase mutants.extracts of aspergillus nidulans wild type (bi-1) and the nitrate reductase mutant niad-17 were active in the in vitro restoration of nadph-dependent nitrate reductase when mixed with extracts of neurospora crassa, nit-1. among the a. nidulans cnx nitrate reductase mutants tested, only the molybdenum repair mutant, cnxe-14 grown in the presence of 10-minus 3 m na2 moo4 was active in the restoration assay. aspergillus extracts contained an inhibitor(s) which was measured by the decrease in nadph- ...1975123779
control of the synthesis of a single enzyme by multiple regulatory circuits in neurospora crassa.neurospora crassa synthesizes and secretes an extracellular protease into its growth medium when an exogenous protein serves as its principal source of sulfur, nitrogen, or carbon. the enzymes produced under these three growth conditions have been compared by a number of criteria. the results indicate that the same extracellular protease with a molecular weight of 31,000 is synthesized during the three different metabolic conditions. a regulatory mutant, which lacks a positive signal required fo ...1975124058
the mutagenicity of azathioprine in mice, drosophila melanogaster and neurospora crassa.the chemotherapeutic coumpound azathioprine was tested for possible mutagenicity in swiss albino mice, drosophila melanogaster and neurospora crassa. utilizing the dominant-lethal assay it was found that acute oral doses of azathioprine (2 times 25 mg/kg body weight), induced dominant-lethal mutations in mouse spermatocytes. chronic oral doses of azathioprine (2 times 25 mg/kg body weight/week for 10 weeks) resulted in a greater rate of dominant-lethality. this increase was not permanent, and by ...1975124817
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