Publications

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the accumulation of acetylmethylcarbinol and acetylethylcarbinol by a mutant of neurospora crassa and its significance in the biosynthesis of isoleucine and valine. 195913610901
the influence of molybdenum toxicity on sulfur amino acid metabolism in neurospora crassa. 195813607471
a possible inversion in the mating-type chromosome of neurospora crassa. 195813598051
a direct method for determination of forward-mutation rates in neurospora crassa. 195813590301
metabolism of nicotinamide and nicotinic acid in neurospora crassa. 195813584324
the genetic control of conidiation in a heterokaryon of neurospora crassa. 195813575750
sulfate inhibition of thiosulfate utilization by certain strains of neurospora crassa. 195813572035
aberrant recombination at the am locus in neurospora crassa. 195813566090
the exclusion of free indole as an intermediate in the biosynthesis of tryptophan in neurospora crassa. 195813560421
kinetics of tyrosine oxidation by crude tyrosinase preparations from neurospora crassa. 195813554558
[metabolic disturbances in neurospora crassa after treatment with the growth-inhibiting hexachlorocyclohexane]. 195813552770
study of folic acid derivatives in neurospora crassa and the recognition of a mutant resistant to aminopterin. 195813549368
measuring linkage in neurospora crassa. 195813548509
effect of sulphanilamide on formation of sterols in saccharomyces cerevisiae and neurospora crassa. 195813535581
the effects of deoxycorticosterone and other steroids on neurospora crassa. 195813534700
activation and thermostability of neurospora crassa tyrosinase. 195813525629
the biosynthesis of aromatic compounds by neurospora crassa. 195813522593
some factors influencing valine and isoleucine transaminase activity in neurospora crassa. 195813522236
para-amino-benzoic acid and sulphanilamide in the nutrition of neurospora crassa. 195813517248
uracil metabolism in neurospora crassa. 195713512284
[the fine structure of the genome in the region of a pab locus of neurospora crassa]. 195713496911
effects of molybdenum, copper and iron on some enzymes in neurospora crassa. 195713491807
the effect of molybdenum deficiency on the catalase and peroxidase content of neurospora crassa. 195713491806
the component fatty acids of neurospora crassa lipides. 195713491602
the cleavage of beta-ketoadipic acie by neurospora crassa. 195713491560
enzyme-inhibitor complex in a tryptophan-requiring mutant of neurospora crassa. 195713486064
the synthesis of chitin in cell-free extracts of neurospora crassa. 195713475355
properties of a protein antigenically related to tryptophan synthetase in neurospora crassa. 195713475242
[incorporation of an anti-inositol substance in the phospholipids of inositolless neurospora crassa]. 195713472319
the use of aminobutyric acid-3-c14 for pyrimidine biogenesis by neurospora crassa. 195713463029
some properties of a zinc-dependent hexokinase from neurospora crassa. 195713459899
uricase in neurospora crassa. 195713459416
[microbiological determination of mesoinositol by a test on neurospora crassa]. 195713459011
the cleavage and synthesis of cystathionine in wild type and mutant strains of neurospora crassa. 195713445714
a modified glutamic acid dehydrogenase as a result of gene mutation in neurospora crassa. 195713426091
arginine synthesis in neurospora crassa; genetic studies. 195713416522
neurospora crassa mutants lacking arginino-succinase. 195713416521
oxalacetic carboxylase deficiency of the succinate-requiring mutants of neurospora crassa. 195713416258
the enzymic synthesis of chitin by extracts of neurospora crassa. 195713412754
a zinc-dependent hexokinase from neurospora crassa. 195713400101
accumulation of adenine-succinic acid by an adenine-requiring mutant of neurospora crassa. 195613395518
s-methyl-l-cysteine as a naturally occurring metabolite in neurospora crassa. 195613395513
trace metal requirements and some enzyme systems in a riboflavin-requiring mutant of neurospora crassa. 195613385430
the biosynthesis of monomethylethanolamine by neurospora crassa. 195613385228
effects of irradiated and reconstituted uridine on growth of a neurospora crassa mutant and synergism between uridine and uracil. 195613372800
studies on 4-aminopyrazolo(3, 4-d)pyrimidine: growth inhibition and relief in neurospora crassa. 195613366933
the nature of the lesion in the succinate-requiring mutants of neurospora crassa: interaction between carbohydrate and nitrogen metabolism. 195613346013
studies on the lethal effect of incorporated p32 and s35 in neurospora crassa. 195613336269
[relations between the passage of amino acids through the cell wall of neurospora crassa in the presence of calcium and strontium in culture media]. 195613330241
a nuclear gene suppressor of a cytoplasmically inherited character in neurospora crassa. 195613306893
effects of amino acids on transaminase production in neurospora crassa: evidence for four different enzymes. 195613293155
amino acid interrelationships in certain leucine-and aromatic-requiring strains of neurospora crassa. 195613286238
evidence for a new precursor of methionine in neurospora crassa. 195513276433
inhibition of histidine uptake in neurospora crassa. 195513252213
on the biosynthesis of proline in neurospora crassa: enzymic reduction of delta1-pyrroline-5-carboxylate. 195513250008
genetic factors influencing the activity of tryptophan desmolase in neurospora crassa. 195413221761
[iodothyronines and growth of neurospora crassa]. 195413218823
effects of a gene mutation in neurospora crassa relating to glutamic dehydrogenase formation. 195413211979
the relation between biotin and tryptophan metabolism studies in neurospora crassa. 195413208638
[effect of inositol antagonist isomytilitol on vitamin balance of neurospora crassa inositolless]. 195413201029
isolation of nutritional mutants of neurospora crassa by filtration enrichment. 195413192298
map construction in neurospora crassa. 195413180445
some factors affecting carbon dioxide metabolism in neurospora crassa. 195413174558
temperature-dependent cellulase production by neurospora crassa and its ecological implications. 195413173446
studies on biosynthesis of carotenoids in neurospora crassa. 195413159302
gene interactions; the mode of action of the suppressor of acetate-requiring mutants of neurospora crassa. 195413152333
the biosynthesis of stable cobaltoproteins by plants. ii. interaction of iron and cobalt metabolism in neurospora crassa. 195313117936
a black mutant of neurospora crassa; mode of action of the mutant allele and action of light on melanogenesis. 195313114906
studies of reverse mutation in neurospora crassa. 195313090280
[experiments on the adaptation of the fungus neurospora crassa to poisons]. 195313087367
haemoglobin in moulds: neurospora crassa and penicillium notatum. 195313087244
properties of mutants of neurospora crassa with low pyruvic carboxylase activity. 195313058369
compounds produced by neurospora crassa in the presence of toxic concentrations of p-aminobenzoic acid. 195212999858
mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation.in the yeast saccharomyces cerevisiae, the integral membrane protein mmm1p is required for maintenance of mitochondrial morphology and retention of mitochondrial dna (mtdna). mmm1p localizes to discrete foci on mitochondria that are adjacent to mtdna nucleoids in the matrix, raising the possibility that this protein plays a direct role in organizing, replicating, or segregating mtdna. although mmm1p has been shown to cross the outer membrane with its c terminus facing the cytoplasm, the location ...200312972421
vivid is a flavoprotein and serves as a fungal blue light photoreceptor for photoadaptation.blue light regulates many physiological and developmental processes in fungi. most of the blue light responses in the ascomycete neurospora crassa are dependent on the two blue light regulatory proteins white collar (wc)-1 and -2. wc-1 has recently been shown to be the first fungal blue light photoreceptor. in the present study, we characterize the neurospora protein vivid. vivid shows a partial sequence similarity with plant blue light photoreceptors. in addition, we found that vivid non-covale ...200312970196
the genetic basis of cellular morphogenesis in the filamentous fungus neurospora crassa.cellular polarity is a fundamental property of every cell. due to their extremely fast growth rate (>/=1 microm/s) and their highly elongated form, filamentous fungi represent a prime example of polarized growth and are an attractive model for the analysis of fundamental mechanisms underlying cellular polarity. to identify the critical components that contribute to polarized growth, we developed a large-scale genetic screen for the isolation of conditional mutants defective in this process in th ...200312960438
calcium gradient dependence of neurospora crassa hyphal growth.a tip-high cytoplasmic calcium gradient has been identified as a requirement for hyphal growth in the fungus neurospora crassa. the ca2+ gradient is less steep compared to wall vesicle, wall incorporation and vesicular ca2+ gradients, but this can be explained by ca2+ diffusion. analysis of the relation between the rate of hyphal growth and the spatial distribution of tip-localized calcium indicates that hyphal growth rates depend upon the tip-localized calcium concentration. it is not the steep ...200312949173
an ordered collection of expressed sequences from cryphonectria parasitica and evidence of genomic microsynteny with neurospora crassa and magnaporthe grisea.cryphonectria parasitica, the causative agent of chestnut blight, has proven to be a tractable experimental system for studying fungal pathogenesis. moreover, the development of infectious cdna clones of c. parasitica hypoviruses, capable of attenuating fungal virulence, has provided the opportunity to examine molecular aspects of fungal plant pathogenesis in the context of biological control. in order to establish a genomic base for future studies of c. parasitica, the authors have analysed a c ...200312949163
identification of a new chondropsin class of antitumor compound that selectively inhibits v-atpases.we identify a new naturally occurring class of inhibitor of vacuolar h+-atpases (v-atpases) isolated from vacuolar membranes of neurospora crassa and from chromaffin granule membranes of bos taurus. to date, the new class includes six chondropsins and poecillastrin a, large polyketide-derived macrolide lactams with 33-37 membered rings. in the national cancer institute's 60-cell screen the chondropsin class showed a tumor cell growth inhibitory fingerprint essentially indistinguishable from that ...200312944415
circadian rhythms in neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2.in neurospora crassa, the circadian rhythm can be seen in the bd (band) strain as a series of "bands" or conidiation (spore-forming) regions on the surface of an agar medium. certain mutations at 3 different genes (frq, wc-1, or wc-2) lead to the loss of the circadian rhythm. in this study, it was found that the addition of 10(-4) to 10(-5) m of geraniol or farnesol restored rhythmic banding to strains that lack a circadian rhythm due to mutations in any 1 of these 3 genes. these 3 conditionally ...200312932081
tina interacts with the nima kinase in aspergillus nidulans and negatively regulates astral microtubules during metaphase arrest.the tina gene of aspergillus nidulans encodes a protein that interacts with the nima mitotic protein kinase in a cell cycle-specific manner. highly similar proteins are encoded in neurospora crassa and aspergillus fumigatus. tina and nima preferentially interact in interphase and larger forms of tina are generated during mitosis. localization studies indicate that tina is specifically localized to the spindle pole bodies only during mitosis in a microtubule-dependent manner. deletion of tina alo ...200312925754
asexual development is increased in neurospora crassa cat-3-null mutant strains.we use asexual development of neurospora crassa as a model system with which to determine the causes of cell differentiation. air exposure of a mycelial mat induces hyphal adhesion, and adherent hyphae grow aerial hyphae that, in turn, form conidia. previous work indicated the development of a hyperoxidant state at the start of these morphogenetic transitions and a large increase in catalase activity during conidiation. catalase 3 (cat-3) increases at the end of exponential growth and is induced ...200312912899
environmental suppression of neurospora crassa cot-1 hyperbranching: a link between cot1 kinase and stress sensing.cot-1 mutants belong to a class of neurospora crassa colonial temperature-sensitive (cot) mutants that exhibit abnormal polar extension and branching patterns when grown at restrictive temperatures. cot-1 encodes a ser/thr protein kinase that is structurally related to the human myotonic dystrophy kinase which, when impaired, confers a disease that involves changes in cytoarchitecture and ion homeostasis. when grown under restrictive conditions, cot-1 cultures exhibited enhanced medium acidifica ...200312912889
import and assembly of neurospora crassa tom40 into mitochondria of trypanosoma brucei in vivo.the tom complex (translocase of the mitochondrial outer membrane) is a dynamic, multisubunit protein complex. tom40 is the major component of the complex and forms the preprotein conducting pore. to determine if a heterologous tom40 could be properly targeted and assembled into the trypanosoma brucei mitochondrial outer membrane, an ectopic copy of a gene encoding neurospora crassa tom40 (nctom40) was expressed in procyclic trypanosomes from a tetracycline regulated procyclic acidic repetitive p ...200312898181
the ph-induced glycosylation of secreted phosphatases is mediated in aspergillus nidulans by the regulatory gene pacc-dependent pathway.in this communication, we show that the pacc(c)14 mutation drastically reduced the mannose and n-acetylglycosamine content of the paca-encoded acid phosphatase secreted by the fungus aspergillus nidulans when grown at 22 degrees c, ph 5.0, compared to a control strain. the staining after page was not observed for the paca-encoded acid phosphatase, while the pald-encoded pi-repressible alkaline phosphatase had an altered electrophoretic mobility. in addition, the secreted acid phosphatase also ha ...200312892641
characterization of the genomic organization of the region bordering the centromere of chromosome v of podospora anserina by direct sequencing.a podospora anserina bac library of 4800 clones has been constructed in the vector pbhyg allowing direct selection in fungi. screening of the bac collection for centromeric sequences of chromosome v allowed the recovery of clones localized on either sides of the centromere, but no bac clone was found to contain the centromere. seven bac clones containing 322,195 and 156,244bp from either sides of the centromeric region were sequenced and annotated. one 5s rrna gene, 5 trna genes, and 163 putativ ...200312892638
the aspergillus nidulans metr gene encodes a bzip protein which activates transcription of sulphur metabolism genes.the identification, isolation and characterization of a new aspergillus nidulans positive-acting gene metr, which encodes a transcriptional activator of sulphur metabolism, is reported. metr mutants are tight auxotrophs requiring methionine or homocysteine for growth. mutations in the metr gene are epistatic to mutations in the negative-acting sulphur regulatory scon genes. the metr coding sequence is interrupted by a single intron of 492 bp which is unusually long for fungi. aspergillus nidulan ...200312890030
a comparison of physical mapping algorithms based on the maximum likelihood model.physical mapping of chromosomes using the maximum likelihood (ml) model is a problem of high computational complexity entailing both discrete optimization to recover the optimal probe order as well as continuous optimization to recover the optimal inter-probe spacings. in this paper, two versions of the genetic algorithm (ga) are proposed, one with heuristic crossover and deterministic replacement and the other with heuristic crossover and stochastic replacement, for the physical mapping problem ...200312874040
genetic analysis of wild-isolated neurospora crassa strains identified as dominant suppressors of repeat-induced point mutation.repeat-induced point mutation (rip) in neurospora results in inactivation of duplicated dna sequences. rip is thought to provide protection against foreign elements such as retrotransposons, only one of which has been found in n. crassa. to examine the role of rip in nature, we have examined seven n. crassa strains, identified among 446 wild isolates scored for dominant suppression of rip. the test system involved a small duplication that targets rip to the easily scorable gene erg-3. we previou ...200312871906
the frequency gene is required for temperature-dependent regulation of many clock-controlled genes in neurospora crassa.the circadian clock of neurospora broadly regulates gene expression and is synchronized with the environment through molecular responses to changes in ambient light and temperature. it is generally understood that light entrainment of the clock depends on a functional circadian oscillator comprising the products of the wc-1 and wc-2 genes as well as those of the frq gene (the frq/wcc oscillator). however, various models have been advanced to explain temperature regulation. in nature, light and t ...200312871904
genome sequencing: the ripping yarn of the frozen genome.the completion of the genome sequence of the filamentous fungus neurospora crassa reveals a gene number very much higher than those of yeasts. of particular interest in this species are the effects of the repeat-induced point mutation (rip) process, which appears to have prevented recent evolution through gene duplication in this lineage.200312867046
suv39h-mediated histone h3 lysine 9 methylation directs dna methylation to major satellite repeats at pericentric heterochromatin.histone h3 lysine 9 (h3-k9) methylation and dna methylation are characteristic hallmarks of mammalian heterochromatin. h3-k9 methylation was recently shown to be a prerequisite for dna methylation in neurospora crassa and arabidopsis thaliana. currently, it is unknown whether a similar dependence exists in mammalian organisms.200312867029
a blumeria graminis gene family encoding proteins with a c-terminal variable region with homologues in pathogenic fungi.in a study aimed at characterising, at the molecular level, the obligate biotrophic fungus blumeria graminis f. sp. hordei (bgh), we have identified a novel group of genes, the egh16h genes, and shown that two of these are up-regulated during primary infection of barley leaves. the genes have partial homology to a previously characterised bgh gene family, egh16. egh16 and egh16h are subfamilies of a larger multigene family with presently about 15 members identified in bgh. egh16h has about ten m ...200312853153
putative functions of nucleoside diphosphate kinase in plants and fungi.the putative functions of ndp (nucleoside diaphosphate) kinases from various organisms focusing to fungi and plants are described. the biochemical reactions catalyzed by ndp kinase are as follows. (i) phosphotransferring activity from mainly atp to cognate ndps generating nucleoside triphosphates (ntps). (ii) autophosphorylation activity from atp and gtp. (iii) protein kinase (phosphotransferring) activity phosphorylating such as myelin basic protein. ndp kinase could function to provide ntps as ...200312848342
the neurospora crassa genome opens up the world of filamentous fungi.the filamentous fungus neurospora crassa, which has played an important role in the development of modern genetics, has several unique genome-defense mechanisms, including a process called repeat-induced point mutation. the draft genome sequence has revealed several unusual features, which suggest that the evolution of n. crassa has been greatly influenced by these defense mechanisms.200312801405
verification of a new gene on saccharomyces cerevisiae chromosome iii.we present verification of the existence of a previously unannotated, intron-containing gene of 134 amino acids (predicted molecular weight approximately 15.5 kda) located on chromosome iii of saccharomyces cerevisiae. strains carrying a deletion of this gene, which we have called ycl012c, reveal no apparent phenotype. orthologues of ycl012c are present in related species s. bayanus, s. paradoxus and ashbya gossypii. comparison with other fungal sequences reveals that orthologues of this gene ar ...200312794934
selectivity of 4,5,6,7-tetrabromobenzimidazole as an atp-competitive potent inhibitor of protein kinase ck2 from various sources.like the previously reported 4,5,6,7-tetrabromobenzotriazole (tbbt), the structurally related 4,5,6,7-tetrabromobenzimidazole (tbbz) is a selective atp-competitive inhibitor of protein kinase ck2 from such divergent sources as yeast, rat liver, neurospora crassa and candida tropicalis, with k(i) values in the range 0.5-1 microm. it is virtually inactive vs. pka, pkc, and a very weak inhibitor of protein kinase ck1. the corresponding tetrachlorobenzimidazole (tcbz) is a much weaker inhibitor of c ...200312788077
antifungal properties of novel n- and alpha,beta-substituted succinimides against dermatophytes.the synthesis and antifungal properties of a series of new n-aryl alpha,beta-substituted succinimides against a panel of dermatophytes of clinical relevance are reported. among those compounds possessing a n-phenyl substituent, 7-thia-2-azabicyclo[2,2,1]hept-2-en-3-amine[5,6-c]succinimide was the better inhibitor of trichophyton rubrum, the major ethiological agent of all infections produced by dermatophytes. in contrast, succinimides containing a n-(p-sulfonylphenyl) substituent, only inhibited ...200312785125
alternative oxidase expression in neurospora crassa.when electron flow through the cytochrome-mediated electron transport chain is blocked by inhibitors or mutations, the mitochondria of neurospora crassa contain a kcn-insensitive alternative oxidase, encoded by the aod-1 gene, that transfers electrons directly from the ubiquinone pool to oxygen. the mechanism by which the enzyme is induced is unknown. comparison of the sequence upstream of the n. crassa aod-1 gene with the corresponding region of gelasinospora spp. and aspergillus nidulans revea ...200312781676
analysis of two additional loci in neurospora crassa related to spore killer-2.two new loci found in one strain of neurospora crassa (p2604) collected in malaya are related to the meiotic drive system spore killer sk-2. sk-2 was found in neurospora intermedia and introgressed into n. crassa. p2604 showed high resistance to killing when crossed to sk-2. this resistance was found to be linked to, but not allelic to, resistance locus r(sk-2) on lgiiil. analysis showed that the high resistance phenotype of p2604 requires resistance alleles at two different loci on lgiiir. stra ...200312781673
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