mechanism of inhibition of hiv-1 infection in vitro by purified extract of prunella vulgaris.crude extracts of four chinese herbs, arctium lappa, astragalus membranaceus, andrographis paniculata, and prunella vulgaris, were assessed in several tissue culture lines for anti-hiv activity and for cytotoxicity. one extract, obtained from p. vulgaris, was able to significantly inhibit hiv-1 replication with relatively low cytotoxicity. the active factor was purified using sequential precipitations with ethanol and n-butanol, followed by reverse-phase and gel permeation high-performance liqui ...19921371029
glycaemic effects of traditional european plant treatments for diabetes. studies in normal and streptozotocin diabetic mice.twelve plants used for the traditional treatment of diabetes mellitus in northern europe were studied using normal and streptozotocin diabetic mice to evaluate effects on glucose homeostasis. the plants were administered in the diet (6.25% by weight) and/or as decoctions or infusions in place of drinking water, to coincide with the traditional method of preparation. treatment for 28 days with preparations of burdock (arctium lappa), cashew (anacardium occidentale), dandelion (taraxacum officinal ...19892743711
in vitro fermentation properties of selected fructooligosaccharide-containing vegetables and in vivo colonic microbial populations are affected by the diets of healthy human infants.salsify (tragopogon porrifolius) and gobo (arctium lappa) are root vegetables that contain high concentrations of naturally occurring fructooligosaccharides (fos), nondigestible oligosaccharides that have prebiotic effects on the intestinal microflora. the objective of this study was to compare colonic microbial populations and the fermentation characteristics of gobo and salsify in breast-fed vs. formula-fed infants. fecal inoculum from breast-fed and formula-fed infants consuming either no sol ...200212163660
screening of some plants used in the brazilian folk medicine for the treatment of infectious diseases.extracts of 13 brazilian medicinal plants were screened for their antimicrobial activity against bacteria and yeasts. of these, 10 plant extracts showed varied levels of antibacterial activity. piper regnellii presented a good activity against staphylococus aureus and bacillus subtilis, a moderate activity on pseudomonas aeruginosa, and a weak activity against escherichia coli. punica granatum showed good activity on s. aureus and was inactive against the other standard strains. eugenia uniflora ...200212471432
lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/sv40 t antigen transgenic rats.arctiin, a plant lignan that can be extracted from the arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis. modifying effects of arctiin on prostate carcinogenesis in probasin/sv 40 t antigen (tag) transgenic (tg) rats were examined. a total of 64 male tg rats, 6 weeks old, were randomly divided to three experimental groups (soybean free oriental mf diet ...200515863263
selective inhibitors of terminal deoxyribonucleotidyltransferase (tdt): baicalin and genistin.studies of mammalian terminal deoxyribonucleotidyltransferase (tdt) are facilitated by use of inhibitors that selectively knock down the activity of the enzyme. we have screened for selective inhibitors of tdt and identified a natural compound with this property in the japanese vegetable, arctium lappa. the compound has little effect on the activities of mammalian dna polymerases, such as alpha, beta, delta or lambda polymerase, and prokaryotic dna polymerases, such as taq dna polymerase, t4 dna ...200516099107
antimicrobial activity of arctium lappa constituents against microorganisms commonly found in endodontic infections.this study evaluated in vitro the antimicrobial activity of rough extracts from leaves of arctium lappa and their phases. the following microorganisms, commonly found in the oral cavity, specifically in endodontic infections, were used: enterococcus faecalis, staphylococcus aureus, pseudomonas aeruginosa, bacillus subtilis and candida albicans. the agar-diffusion method allowed detection of the hexanic phase as an inhibitor of microbial growth. bioautographic assays identified antimicrobial subs ...200616429183
in vitro evaluation of the antibacterial activity of arctium lappa as a phytotherapeutic agent used in intracanal dressings.the discovery of natural biocomponents from plants with antibacterial activity on endodontic microbiota may lead to new therapies. this study evaluated the antibacterial activity of a phytotherapeutic agent prepared from an ethyl acetate fraction (acoet) extracted from arctium lappa. this agent was compared with calcium hydroxide as an intracanal dressing. twenty-seven maxillary canines were instrumented, sterilized and inoculated with a mixed bacterial suspension of pseudomonas aeruginosa, esch ...200616521107
behavioural response of colorado potato beetle (leptinotarsa decemlineata) larvae to selected plant extracts.potato leaves were treated with 2, 20 or 200 g kg(-1) solutions of extracts of five plant species collected in turkey, and then exposed to larvae of colorado potato beetle, leptinotarsa decemlineata (say). during the first 24 h of exposure, leaf consumption was not affected by 2 g kg(-1) extracts, whereas significantly more leaf tissue remained on leaves treated with 20 g kg(-1) extracts of arctium lappa l., bifora radians m bieb, humulus lupulus l. or xanthium strumarium l. than on untreated co ...200616886174
ethnoveterinary medicines used for ruminants in british columbia, canada.the use of medicinal plants is an option for livestock farmers who are not allowed to use allopathic drugs under certified organic programs or cannot afford to use allopathic drugs for minor health problems of livestock.200717324258
parasitic hymenoptera fauna on agromyzidae (diptera) colonizing weeds in ecological compensation areas in northern italian agroecosystems.parasitoids (hymenoptera) associated with agromyzid leafminers (diptera: agromyzidae) were studied in three rural farms located in northern italy. the parasitoids were reared from mined foliage of weeds growing in field margins. we reared 998 hymenoptera specimens, representing five families, 23 genera, and 53 species, from leafminers infesting weeds. eulophidae was the most abundant family (67.64%), followed by braconidae (28.86%), eucoilinae (1.40%), tetracampidae (1.40%), and pteromalidae (0. ...200717461050
[betamethasone and aqueous extract of arctium lappa for treating angiostrongyliasis].angiostrongylus costaricensis is a parasite that causes abdominal angiostrongyliasis in humans. the treatment for it includes the use of anti-inflammatory drugs, despite the lack of studies to justify this approach. the objective of this paper was to evaluate the effect of betamethasone and arctium lappa on the evolution of intestinal lesions induced by this parasite. adult male swiss mice were used, distributed into four groups: infected and treated with betamethasone; infected and treated with ...200819142447
natural arctium lappa fruit extract improves the clinical signs of aging skin.subclinical, chronic tissue inflammation involving the generation of cytokines (e.g., interleukin-6 and tumor necrosis factor-alpha) might contribute to the cutaneous aging process.200819146605
in vitro screening of traditional medicines for anti-hiv activity: memorandum from a who meeting.many plant products are being used by patients with acquired immunodeficiency syndrome (aids) in some countries without any scientific proof that they possess anti-hiv (human immunodeficiency virus) activity. traditional healers are now offering their remedies for scientific evaluation, and a few studies provide information on the inhibitory activity against hiv of plants such as viola yedoensis, arctium lappa, epimedium grandiflorum, glycyrrhiza uralensis and castanospermum australe. natural pr ...19892633879
characterisation of phenolics in flor-essence--a compound herbal product and its contributing herbs.commercially available herbal mixture fe, a proprietary natural health product manufactured by flora manufacturing and distributing ltd (flora), is a unique north american traditional herbal product. fe is a chemically complex mixture of eight herbs and has not been subjected to phytochemical analysis.200919609882
arctiin induces cell growth inhibition through the down-regulation of cyclin d1 expression.arctiin is a major lignan constituent of arctium lappa and has anti-cancer properties in animal models. it was recently reported that arctiin induces growth inhibition in human prostate cancer pc-3 cells. however, the growth inhibitory mechanism of arctiin remains unknown. herein we report that arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte hacat cells. we also show that the growth inhibition caused by arctiin ...200818288407
the antitussive activity of polysaccharides from althaea officinalis l., var. robusta, arctium lappa l., var. herkules, and prunus persica l., batsch.the therapy of pathological type of cough presents serious medical problem.200717685009
screening of dried plant seed extracts for adiponectin production activity and tumor necrosis factor-alpha inhibitory activity on 3t3-l1 search for dried plant seeds with potent anti-diabetes activity, we conducted a large scale screening for inhibitory activity on tumor necrosis factor-alpha and facilitating activity on adiponectin production in vitro. these activities in 3t3-l1 adipocytes were screened from ethanol extracts of 20 kinds of dried plant seed marketed in japan. komatsuna (brassica rapa var. perviridis), common bean (phaseolus vulgaris l.), qing geng cai (brassica rapa var. chinensis), green soybean (glycine max) ...201020717728
effect of arctium lappa l. in the dextran sulfate sodium colitis mouse analyze the possible protective role of arctium lappa l. (al) in a murine model of ulcerative colitis (uc).201020806438
[effect compound decoction on notoginsenosides in panax notoginseng].to explore the effect of compound decoction on notoginsenosides in panax notoginseng.200717655142
arctigenin isolated from the seeds of arctium lappa ameliorates memory deficits in mice.the seeds of arctium lappa l. (al, family asteraceae), the main constituents of which are arctiin and arctigenin, have been used as an herbal medicine or functional food to treat inflammatory diseases. these main constituents were shown to inhibit acetylcholinesterase (ache) activity. arctigenin more potently inhibited ache activity than arctiin. arctigenin at doses of 30 and 60?mg/kg (p.?o.) potently reversed scopolamine-induced memory deficits by 62?% and 73?%, respectively, in a passive avoid ...201121308615
antioxidative and in vitro antiproliferative activity of arctium lappa root extracts.arctium lappa, known as burdock, is widely used in popular medicine for hypertension, gout, hepatitis and other inflammatory disorders. pharmacological studies indicated that burdock roots have hepatoprotective, anti-inflammatory, free radical scavenging and antiproliferative activities. the aim of this study was to evaluate total phenolic content, radical scavenging activity by dpph and in vitro antiproliferative activity of different a. lappa root extracts.201121429215
trial of essiac to ascertain its effect in women with breast cancer (tea-bc).breast cancer is a major cause of morbidity, mortality, and medical expenditures among women in canada. essiac (resperin canada limited, waterloo, ontario, canada), a blend of at least four herbs (burdock root [arctium lappa], indian rhubarb [rheum palmatum], sheep sorrel [rumex acetosella], and the inner bark of slippery elm [ulmus fulva or u. rubra]), has become one of the more popular herbal remedies for breast-cancer treatment, secondary prevention, improving quality of life, and controlling ...200617212569
anatomy of subterranean organs of medicinally used cardueae and related species and its value for discrimination.numerous species of the asteraceae, the composites, are famous for their use in both traditional and conventional medicine. reliable anatomical descriptions of these plants and of possible adulterations provide a basis for fast identification and cheap purity controls of respective medicinal drugs by means of light microscopy. nevertheless, detailed comparative studies on root and rhizome anatomy of valuable as well as related inconsiderable composite plants are largely missing yet. the presente ...201121617780
organic parasite control for poultry and rabbits in british columbia, canada.abstract: plants used for treating endo- and ectoparasites of rabbits and poultry in british columbia included arctium lappa (burdock), artemisia sp. (wormwood), chenopodium album (lambsquarters) and c. ambrosioides (epazote), cirsium arvense (canada thistle), juniperus spp. (juniper), mentha piperita (peppermint), nicotiana sp. (tobacco), papaver somniferum (opium poppy), rubus spp. (blackberry and raspberry relatives), symphytum officinale (comfrey), taraxacum officinale (common dandelion), th ...201121756341
Efficacy of natural L-asparagine in the complex therapy for malignant tumors in experimental studies.To study the influence of natural L-asparagine on the efficacy of cytostatic therapy for malignant tumors in experimental investigations.201121716205
identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.tumor cells generally proliferate rapidly and the demand for essential nutrients as well as oxygen always exceeds the supply due to the unregulated growth and the insufficient and inappropriate vascular supply. however, cancer cells show an inherent ability to tolerate extreme conditions, such as that characterized by low nutrient and oxygen supply, by modulating their energy metabolism. thus, targeting nutrient-deprived cancer cells may be a novel strategy in anticancer drug development. based ...200616452235
enzymatic production of caffeic acid by koji from plant resources containing caffeoylquinic acid derivatives.the effect of a koji (aspergillus awamori mut.) extract on the caffeoylquinic acid derivatives purified from sweetpotato (ipomoea batatas l.) leaves was examined to develop the mass production of caffeic acid. a koji extract hydrolyzed the caffeoylquinic acid derivatives, chlorogenic acid, 3,4-di-o-caffeoylquinic acid, 3,5-di-o-caffeoylquinic acid, 4,5-di-o-caffeoylquinic acid and 3,4,5-tri-o-caffeoylquinic acid, to caffeic acid. furthermore, the koji extract also converted the major polyphenoli ...200516195601
arctigenin, a potent ingredient of arctium lappa l., induces endothelial nitric oxide synthase and attenuates subarachnoid hemorrhage-induced vasospasm through pi3k/akt pathway in a rat model.upregulation of protein kinase b (pkb, also known as akt) is observed within the cerebral arteries of subarachnoid hemorrhage (sah) animals. this study is of interest to examine arctigenin, a potent antioxidant, on endothelial nitric oxide synthase (enos) and akt pathways in a sah in vitro study. basilar arteries (bas) were obtained to examine phosphatidylinositol-3-kinase (pi3k), phospho-pi3k, akt, phospho-akt (western blot) and morphological examination. endothelins (ets) and enos evaluation ( ...201526539501
characterization of burdock mottle virus, a novel member of the genus benyvirus, and the identification of benyvirus-related sequences in the plant and insect genomes.the complete nucleotide sequence of the burdock mottle virus (bdmov) isolated from an edible burdock plant (arctium lappa) in japan has been determined. bdmov has a bipartite genome, whose organization is similar to rna1 and rna2 of benyviruses, beet necrotic yellow vein virus (bnyvv), beet soil-borne mosaic virus (bsbmv), and rice stripe necrosis virus (rsnv). bdmov rna1 (7038 nt) contains a single open reading frame (orf) encoding a 249-kda polypeptide that consists of methyl-transferase, heli ...201323911632
control of microorganisms of oral health interest with arctium lappa l. (burdock) extract non-cytotoxic to cell culture of macrophages (raw 264.7).to evaluate the antimicrobial activity of arctium lappa l. extract on staphylococcus aureus, s. epidermidis, streptococcus mutans, candida albicans, c. tropicalis and c. glabrata. in addition, the cytotoxicity of this extract was analyzed on macrophages (raw 264.7).201424863657
a biologically active fructan from the roots of arctium lappa l., var. herkules.from the roots of arctium lappa l., var. herkules a low-molecular-weight fructofuranan of the inulin-type has been isolated by water extraction and ethanol precipitation, followed by ion-exchange chromatography and gel filtration of the crude precipitate. the methods employed in structural determination were methylation analysis and 1h and 13c nmr spectral measurements. in tests for antitussive activity in cats the fructan was found to be equally active as some non-narcotic, synthetic preparatio ...200314599596
transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria.after anaerobic incubation of arctiin (1) from the seeds of arctium lappa with a human fecal suspension, six metabolites were formed, and their structures were identified as (-)-arctigenin (2), (2r,3r)-2-(3',4'-dihydroxybenzyl)-3-(3",4"-dimethoxybenzyl)butyrolactone (3), (2r,3r)-2-(3'-hydroxybenzyl)-3-(3",4"-dimethoxybenzyl)butyrolactone (4), (2r,3r)-2-(3'-hydroxybenzyl)-3-(3"-hydroxy-4"-methoxybenzyl)butyrolactone (5), (2r,3r)-2-(3'-hydroxybenzyl)-3-(3",4"-dihydroxybenzyl)butyrolactone (6), and ...200312672988
hepatoprotective effects of arctium lappa linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride.arctium lappa linne (burdock) is a perennial herb which is popularly cultivated as a vegetable. in order to evaluate its hepatoprotective effects, a group of rats (n = 10) was fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (ccl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of a. lappa treatment). control gr ...200212218354
antitubercular activity of arctium lappa and tussilago farfara extracts and constituents.arctium lappa and tussilago farfara (asteraceae) are two plant species used traditionally as antitubercular remedies. the aim of this study was (i) to screen arctium lappa and tussilago farfara extracts for activity against mycobacterium tuberculosis and (ii) to isolate and identify the compound(s) responsible for this reputed anti-tb effect.201424955560
[epiphytic phase of erwinia amylovora and pseudomonas syringae pv. syringae on orchard weeds].epiphyte phase of phytopathogenic bacteria erwinia amylovora and pseudomonas syringae pv. syringae on the fruit garden weeds has been studied. it has been shown that healthy weeds of the fruit-tree stands can be an ecologic niche for erwinia amylovora and pseudomonas syringae pv. syringae which gives them an opportunity to survive as epiphytes. strains of pseudomonas syringae pv. syringae were isolated from seven studied weeds (47-49%) during the whole vegetation period (march-october). strains ...200111785263
the effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors of pseudomonas aeruginosa.this study aimed to evaluate the effect of a fraction of burdock (arctium lappa l.) leaf on the initial adhesion, biofilm formation, quorum sensing and virulence factors of pseudomonas aeruginosa.201727860087
effects of arctiin on phip-induced mammary, colon and pancreatic carcinogenesis in female sprague-dawley rats and meiqx-induced hepatocarcinogenesis in male f344 rats.chemopreventive effects of arctiin, a lignan isolated from arctium lappa (burdock) seeds, on the initiation or post initiation period of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip) induced mammary carcinogenesis in female rats and on 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (meiqx)-associated hepatocarcinogenesis in male rats were examined. in experiment 1, female sprague-dawley (sd) rats were given intragastric doses of 100 mg/kg body wt of phip once a week for 8 weeks as initi ...200010814883
studies on differentiation inducers. vi. lignan derivatives from arctium fructus. (2).in the previous paper, we reported the differentiation inducing activities of lignoids from arctium fructus (the fruits of arctium lappa l., compositae) against mouse myeloid leukemia cells (m1). we reinvestigated the active components of this extract and isolated three new dilignans. furthermore, structure modifications were carried out using the most active lignan (arctigenin, 1) and its structure-activity relationship was investigated. its aliphatic esters were more effective in inducing the ...19968996860
anti-inflammatory and radical scavenge effects of arctium lappa.the effects of arctium lappa l. (root) on anti-inflammatory and free radical scavenger activity were investigated. subcutaneous administration of a. lappa crude extract significantly decreased carrageenan-induced rat paw edema. when simultaneously treated with ccl4, it produced pronounced activities against ccl4-induced acute liver damage. the free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (esr) spectrometer. the ic50 of a. lappa ex ...19968874669
dietary fiber and fat-derivatives prevent mineral oil toxicity in rats by the same mechanism.the inclusion of 8% mineral oil in a fat-free diet causes severe growth retardation in rats. in the present study, this growth retardation was found to be primarily due to the reduction in nutrient intake, but not to the exacerbation of essential fatty acid deficiency. in addition, the growth retardation caused by mineral oil ingestion was prevented by the concurrent inclusion of 10% water-insoluble dietary fiber [gobo fiber prepared from arctium lappa l. (gobo in japanese) or cotton cellulose p ...19938395595
urolithiasis and phytotherapy.the effects of seven plants with suspected application to prevent and treat stone kidney formation (verbena officinalis, lithospermum officinale, taraxacum officinale, equisetum arvense, arctostaphylos uva-ursi, arctium lappa and silene saxifraga) have been studied using female wistar rats. variations of the main urolithiasis risk factors (citraturia, calciuria, phosphaturia, ph and diuresis) have been evaluated. it can be concluded that beneficial effects caused by these herb infusions on uroli ...19947860196
a desmutagenic factor isolated from burdock (arctium lappa linne).a desmutagenic factor was isolated from burdock (arctium lappa linne). this factor reduced the mutagenicity of mutagens that are active without metabolic activation, such as 4-no2-1,2-dab and 2-no2-1,4-dab, as well as mutagens such as ethidium bromide, 2-aminoanthracene, trp-p-1 and trp-p-2 requiring s9 for metabolic activation. it is resistant to heat and proteolytic enzymes and sensitive to treatment with mncl2. the partially purified principles had a molecular weight higher than 300 000 and s ...19846387466
xanthium italicum, xanthium strumarium and arctium lappa as new hosts for diaporthe helianthi.sunflower (helianthus annuus) stem canker caused by diaporthe helianthi is one of the most important sunflower diseases in croatia. until recently, sunflower was the only known host for d. helianthi. in our research carried out in the area of eastern croatia, isolates of diaporthe/phomospis were collected from xanthium italicum, x. strumarium and arctium lappa. using morphological, cultural and molecular its rdna data, isolates from these weeds were identified as d. helianthi. the following isol ...201020182800
the anti-metastatic effects of the phytoestrogen arctigenin on human breast cancer cell lines regardless of the status of er expression.arctigenin is a plant lignan extracted from arctium lappa that has been shown to have estrogenic properties. in spite of the health benefits of phytoestrogens reducing the risk of osteoporosis, heart disease, and menopausal symptoms, its benefits against the risk of breast cancer have not been fully elucidated. thus, we investigated the effects of arctigenin on metastasis of breast cancer using both estrogen receptor (er)-positive mcf-7 and er-negative mda-mb-231 human breast cancer cell lines t ...201728035371
room temperature ionic liquids-based salting-in strategy for counter-current chromatography in the separation of arctiin.counter-current chromatography (ccc) is a solid support-free liquid-liquid partition chromatography and has wide applications. however, ccc separation is still a challenging process and the selection of appropriate solvent system for separation of target compound(s) is still relatively time-consuming. in this work, we introduced a room temperature ionic liquids-based salting-in strategy for the rapid selection of suitable solvent systems for ccc separation. in the randomly selected solvent syste ...201627932083
effect of feeding amaranth (food red no. 2) on the jejunal sucrase and digestion-absorption capacity of the jejunum in clarify the effect of feeding 5% amaranth (food red no. 2, am) alone or with 5% dietary fiber on jejunal mucosal integrity, change in jejunal sucrase activity before and after the feeding was compared between rats fed and fasted previously. digestion-absorption capacity of the jejunum was also examined by perfusing 15 mmol/liter sucrose and 30 mmol/liter glycylglycine through the anesthetized rat jejunum after 14 days of feeding am. gobo dietary fiber (gdf) was prepared from the roots of edib ...19911668101
platelet activating factor (paf) antagonists contained in medicinal plants: lignans and aqueous extracts of medicinal plants were tested for their inhibitory effect on the binding of platelet activating factor (paf) to rabbit platelets. the extracts of forsythia suspensa vahl. (oleaceae), arctium lappa l. (compositae) and centipeda minima (l.) a. braun et aschers (compositae) showed significant activities. since the main constituents of f. suspensa and a. lappa are lignans, 30 lignans were tested for their inhibitory effects on paf binding to platelets and 9 lignans were found ...19921394633
structural transformation of lignan compounds in rat gastrointestinal tract.structural transformation of arctiin and tracheloside, major components of seeds of arctium lappa and carthamus tinctorius, were investigated using rat gastric juice (ph 1.2-1.5) and rat large intestinal flora in vitro. quantitative analysis of lignans and their metabolites was carried out by high performance liquid chromatography. both lignans were stable in rat gastric juice and arctiin was rapidly transformed to arctigenin in rat large intestinal flora, followed by conversion to the major met ...19921336605
correlation between the physical properties of dietary fibers and their protective activity against amaranth toxicity in rats.the mechanism(s) by which dietary fiber (df) exerts beneficial effects on the growth of weanling rats fed toxic doses of amaranth (food & c red no. 2) was investigated. when crude df (gdf) prepared from the roots of edible burdock (arctium lappa l.) were added at graded levels to a purified basal diet supplemented with amaranth (control), growth was improved with increaseing gdf level up to and above that of the basal diet-fed group. the correlation equation obtained between the dietary percenta ...1979430240
evaluation of the use of different solvents to extract the four main components of yinqiaosan and their in vitro inhibitory effects on influenza-a virus.high-performance liquid chromatography coupled with an ultraviolet detector was used to quantitatively determine the amount of caffeoylquinic acid, arctium lappa glycoside, aurantiamarin and forsythin present in five solvent extracts (water, 30% ethanol, 50% ethanol, 70% ethanol and 95% ethanol) of yinqiaosan (yqs). the calibration curves of the four components were linear (r(2) > 0.998) over the concentration range of 0.9-151.5 microg/ml. this method showed good repeatability with relative stan ...201020434099
ameliorative effects of arctiin from arctium lappa on experimental glomerulonephritis in rats.membranous glomerulonephritis (mgn) remains the most common cause of adult-onset nephrotic syndrome in the world and up to 40% of untreated patients will progress to end-stage renal disease. although the treatment of mgn with immunosuppressants or steroid hormones can attenuate the deterioration of renal function, numerous treatment-related complications have also been established. in this study, the ameliorative effects of arctiin, a natural compound isolated from the fruits of arctium lappa, o ...200919524415
in vitro and in vivo anti-allergic effects of arctium lappa l.the discovery of drugs that can be used for the treatment of allergic disease is important in human health. arctium lappa linne (compositae) (al) has been used as a traditional medicine in brazil and throughout asia and is known to have an anti-inflammatory effect. in this study, the inhibitory effects of al on degranulation and the release of mediators as well as on inhibition of cys-leukotriene biosynthesis by basophils were investigated. al was selected out of 10,000 herbal extracts in a set- ...200818703753
gastroprotective activity of the chloroform extract of the roots from arctium lappa l.arctium lappa l. is used in folk medicine as a diuretic, depurative and digestive stimulant and in dermatological conditions. the objective of this study was to evaluate the effect and the possible mechanisms involved in the gastroprotective effects of a chloroform extract (ce) of the roots from a. lappa and its fractions. oral pretreatment with ce (10, 30 and 100 mg kg(-1)) significantly reduced gastric lesions induced by ethanol by 61%, 70% and 76%, respectively. oral administration of ce (100 ...200818498717
therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza a virus.arctiin and its aglucone, arctigenin from the fruits of arctium lappa l. showed potent in vitro antiviral activities against influenza a virus (a/nws/33, h1n1) (ifv). based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells. arctiin was orally effective against either ifv-inoculated ...201020606313
anti-allergic and anti-inflammatory effects of butanol extract from arctium lappa l. 201121303540
arctigenin from arctium lappa inhibits interleukin-2 and interferon gene expression in primary human t lymphocytes. 201121435270
arctigenin efficiently enhanced sedentary mice treadmill endurance.physical inactivity is considered as one of the potential risk factors for the development of type 2 diabetes and other metabolic diseases, while endurance exercise training could enhance fat oxidation that is associated with insulin sensitivity improvement in obesity. amp-activated protein kinase (ampk) as an energy sensor plays pivotal roles in the regulation of energy homeostasis, and its activation could improve glucose uptake, promote mitochondrial biogenesis and increase glycolysis. recent ...201121887385
effects of drugs of plant origin on the development of the immune response.the effects of extracts from licorice (glycyrrhisa glabra), great nettle (urtica dioica), common burdock (arctium lappa), and bur marigold (bidens tripartite) on the humoral and cellular immune response and nonspecific resistance in mice were studied. burdock and bur marigold extracts stimulated the humoral immune response, nettle and licorice extracts stimulated cellular response and nonspecific resistance, their effects being superior to those of pharmacopoeial echinacea purpurea tincture.201122238748
effect of using different vehicles on the physicochemical, antimicrobial, and biological properties of white mineral trioxide aggregate.this study evaluated the physicochemical, antimicrobial, and biological properties of white mineral trioxide aggregate (mta) mixed with aqueous and propylene glycol extracts of arctium lappa l. and casearia sylvestris sw.201728320540
antibacterial, antibiofilm effect of burdock (arctium lappa l.) leaf fraction and its efficiency in meat preservation.first, the antibacterial, antibiofilm effect and chemical composition of burdock (arctium lappa l.) leaf fractions were studied. then, the efficiency of burdock leaf fractions in pork preservation was evaluated. the results showed that burdock leaf fraction significantly inhibited the growth and biofilm development of escherichia coli and salmonella typhimurium. mics of burdock leaf fractions on e. coli and salmonella typhimurium were both 2 mg/ml. at a concentration of 2.0 mg/ml, the inhibition ...201627497128
use of arctium lappa extract against acetaminophen-induced hepatotoxicity in rats.severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure.201526543508
arctigenin suppress th17 cells and ameliorates experimental autoimmune encephalomyelitis through ampk and ppar-γ/ror-γt signaling.arctigenin is a herb compound extract from arctium lappa and is reported to exhibit pharmacological properties, including neuronal protection and antidiabetic, antitumor, and antioxidant properties. however, the effects of arctigenin on autoimmune inflammatory diseases of the cns, multiple sclerosis (ms), and its animal model experimental autoimmune encephalomyelitis (eae) are still unclear. in this study, we demonstrated that arctigenin-treated mice are resistant to eae; the clinical scores of ...201626440666
[study on high-yield cultivation measures for arctii fructus].to find out the high yield cultivation measures for arctii fructus.201526415394
burdock root extracts limit quorum-sensing-controlled phenotypes and biofilm architecture in major urinary tract pathogens.bacterial biofilms are serious concern in patients infected with urinary tract infections, complicated urinary tract infections and other device-associated infections. microbes within the biofilms are effectively shielded from antibiotics and host immune cells, hence can be treated only with agents which has the potential to disassemble the biofilms. the study is focused on the root extracts of arctium lappa linn. as a source for complementary medicine against three major biofilm forming clinica ...201525226848
the antiviral activity of arctigenin in traditional chinese medicine on porcine circovirus type 2.arctigenin (act) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb arctium lappa l. (compositae) with anti-viral and anti-inflammatory effects. here, we investigated the antiviral activity of act found in traditional chinese medicine on porcine circovirus type 2 (pcv2) in vitro and in vivo. results showed that dosing of 15.6-62.5μg/ml act could significantly inhibit the pcv2 proliferation in pk-15 cells (p<0.01). dosing of 62.5μg/ml act 0, 4 or 8h after challe ...201627234554
therapeutic effect of arctium lappa in schistosoma haematobium associated kidney disturbance: biochemical and molecular effects.schistosoma haematobium (s. haematobium) infection has been found to be strongly associated with bladder cancer, which necessitates for discover of a natural new therapeutic agent. the aim of this study was to evaluate the therapeutic effect of arctium lappa seed extract in s. haematobium associated kidney disturbance. forty male albino mice were used and divided into four equal groups; group 1 control includes non-infected healthy mice, groups 2, 3 and 4 subcutaneous infected with s. haematobiu ...201627876925
contact dermatitis as an adverse reaction to some topically used european herbal medicinal products - part 1: achillea millefolium-curcuma longa.this review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the european medicines agency has completed an evaluation up to the end of november 2013 and for which a community herbal monograph has been produced. part 1: achillea millefolium l.-curcuma longa l.201424621152
antioxidative/acetylcholinesterase inhibitory activity of some asteraceae plants.the extracts obtained by 80% etoh from some asteraceae plants (calendula officinalis, inula helenium, arctium lappa, artemisia absinthium and achillea millefolium) were studied. rosmarinic acid, one of the main compounds identified in all extracts, was determined quantitatively by using hplc. in addition, spectrophotometric methods were evaluated as an alternative for rosmarinic acid content determination. total phenolic content was also established for all extracts. a. millefolium extract was f ...201323738456
the immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: a review.breast cancer has continued to cause high cancer death rates among women worldwide. the use of plants' natural products in breast cancer treatment has received more attention in recent years due to their potentially wider safety margin and the potential to complement conventional chemotherapeutic drugs. plant-based products have demonstrated anticancer potential through different biological pathways including modulation of the immune system. immunomodulatory properties of medicinal plants have b ...201627539316
four new neolignan glucosides from the fruits of arctium lappa.four new neolignan glucosides named (7s, 8r)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-o-4'-neolignan-9'-o-β-d-apiofuranosyl-(1 → 6)-o-β-d-glucopyranoside (1), (8r)-4,9,9'-trihydroxy-3,3'-dimethoxy-7-oxo-8-o-4'-neolignan-4-o-β-d-glucopyranoside (2), (7r, 8s)-dihydrodehydrodiconiferyl alcohol-7'-oxo-4-o-β-d-glucopyranoside (3), and (7's, 8'r, 8s)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-o-β-d-glucopyranoside (4) were isolated from the fruits of arctium lappa l. their structures and ...201525978776
natural cures for breast cancer treatment.for centuries, herbs and plants have been used for medicinal purposes and as food as well. this review concerns about different types of plants that retain the immune stimulating and anti-tumor properties. large variety of active phytochemicals such as carotenoids, flavonoids, ligands, polyphenolics, terpenoids, sulfides, lignans and plant sterols has been identified in different types of herbs. these phytochemicals have different mechanisms of action. they either stimulate the protective enzyme ...201627275107
antidiabetic, hypolipidemic and hepatoprotective effects of arctium lappa root's hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice.arctium lappa (burdock), (a. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. this study was conducted to evaluate the antidiabetic and hypolipidemic properties of a. lappa root extract on nicotinamide-streptozotocin (na-stz)-induced type2 diabetes in mice.201728348972
protective effect of arctigenin on ethanol-induced neurotoxicity in pc12 a neurotropic substance, ethanol can damage nerve cells through an increase in the production of free radicals, interference of neurotrophic factor signaling pathways, activation of endogenous apoptotic signals and other molecular mechanisms. previous studies have revealed that a number of natural drugs extracted from plants offer protection of nerve cells from damage. among these, arctigenin (atg) is a lignine extracted from arctium lappa (l.), which has been found to exert a neuroprotective ...201728260103
identification of a dicaffeoylquinic acid isomer from arctium lappa with a potent anti-ulcer activity.leaves of arctium lappa contain several mono- and dicaffeoylquinic acids, as evaluated by liquid chromatography-mass spectrometry. in order to investigate the protection on gastric mucosa against ulcers, rats were treated with fractions from leaf extract prior to ethanol-induced ulcers. the original fraction obtained as ethanol soluble fraction from hot aqueous extract was able to protect de gastric mucosa, and this effect was retained in the ethyl acetate fraction, obtained from liquid/liquid f ...201525640125
arctigenin protects against lipopolysaccharide-induced pulmonary oxidative stress and inflammation in a mouse model via suppression of mapk, ho-1, and inos signaling.arctigenin, a bioactive component of arctium lappa (nubang), has anti-inflammatory activity. here, we investigated the effects of arctigenin on lipopolysaccharide (lps)-induced acute lung injury. mice were divided into four groups: control, lps, lps + dmso, and lps + arctigenin. mice in the lps + arctigenin group were injected intraperitoneally with 50 mg/kg of arctigenin 1 h before an intratracheal administration of lps (5 mg/kg). lung tissues and bronchoalveolar lavage fluids (balfs) were coll ...201525616905
phase i trial of gbs-01 for advanced pancreatic cancer refractory to gemcitabine.gbs-01, an extract from the fruit of arctium lappa l. is an orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by attenuating the tolerance of cancer cells to glucose deprivation. we investigated the maximum tolerated dose of gbs-01 based on the frequency of the dose-limiting toxicities (dlts) and pharmacokinetics in patients with advanced pancreatic cancer refractory to gemcitabine. gbs-01 was given orally at escalating doses from 3.0 g (containing ...201627685612
chemical analysis of raw and processed fructus arctii by high-performance liquid chromatography/diode array detection-electrospray ionization-mass traditional chinese medicine (tcm), raw and processed herbs are used to treat the different diseases. fructus arctii, the dried fruits of arctium lappa l. (compositae), is widely used in the tcm. stir-frying is the most common processing method, which might modify the chemical compositions in fructus arctii.201425422559
behavioral and electroantennogram responses of plum curculio, conotrachelus nenuphar, to selected noxious plant extracts and insecticides.behavioral and electroantennogram responses of plum curculio, conotrachelus nenuphar (herbst) (coleoptera: curculionidae), adults were tested for several methanolic plant extracts and organically approved insecticides. plant extracts were evaluated for their potential as antifeedants or oviposition deterrents. these extract responses were also compared to those elicited by the non-neurotoxic, organic irritant-insecticide kaolin clay. both sexes of plum curculio exhibited antennal response as mea ...201425368046
new phytochemicals as potential human anti-aging compounds: reality, promise, and challenges.aging is an inevitable process influenced by genetic, lifestyle and environmental factors. indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. this report aims to provide a critical review on aspects related to the use of novel phytochemicals as anti-aging agents, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives. in addition to the ...201627623718
effects of arctium lappa l. (burdock) root tea on inflammatory status and oxidative stress in patients with knee osteoarthritis.this study was designed to examine the effect of burdock root tea on inflammatory markers and oxidative stress indicators in patients with knee osteoarthritis (oa).201625350500
arctiin blocks hydrogen peroxide-induced senescence and cell death though microrna expression changes in human dermal papilla cells.accumulating evidence indicates that reactive oxygen species (ros) are an important etiological factor for the induction of dermal papilla cell senescence and hair loss, which is also known alopecia. arctiin is an active lignin isolated from arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. in the present study, we found that arctiin exerts anti-oxidative effects on human hair dermal papilla cells (hhdpcs).201425299961
polysaccharides from arctium lappa l.: chemical structure and biological activity.the plant arctium lappa l. is popularly used to relieve symptoms of inflammatory disorders. a crude polysaccharide fraction (saa) resulting of aqueous extraction of a. lappa leaves showed a dose dependent anti-edematogenic activity on carrageenan-induced paw edema, which persisted for up to 48h. sequential fractionation by ultrafiltration at 50kda and 30kda cut-off membranes yielded three fractions, namely rf50, rf30, and ef30. all these maintained the anti-edematogenic effect, but rf30 showed a ...201627311502
antiallergic activity of ethanol extracts of arctium lappa l. undried roots and its active compound, oleamide, in regulating fcεri-mediated and mapk signaling in rbl-2h3 cells.the antiallergic potential of arctium lappa l. was investigated in sprague-dawley rats, icr mice, and rbl-2h3 cells. ethanol extract (90%) of a. lappa (ale, 100 μg/ml) inhibited the degranulation rate by 52.9%, determined by the level of β-hexosaminidase. ale suppressed passive cutaneous anaphylaxis (pca) in rats and attenuated anaphylaxis and histamine release in mice. to identify the active compound of ale, we subsequently fractionated and determined the level of β-hexosaminidase in all subfra ...201627087645
usefulness of different vascular plant species for passive biomonitoring of mediterranean rivers.choosing native vascular plants as nutrient and toxic element accumulators for passive biomonitoring of urban river quality is not an easy task in mediterranean rivers, due to the particular climate determining high variations in river hydrology. to identify potential biomonitors for this area, the roots of seven species (angelica sylvestris, apium nodiflorum, tradescantia fluminensis, nasturtium officinale, persicaria lapathifolia, arctium lappa, typha latifolia), growing in seven sites along t ...201627040538
effect of plant extracts on h2o2-induced inflammatory gene expression in macrophages.arctium lappa (al), camellia sinensis (cs), echinacea angustifolia, eleutherococcus senticosus, panax ginseng (pg), and vaccinium myrtillus (vm) are plants traditionally used in many herbal formulations for the treatment of various conditions. although they are well known and already studied for their anti-inflammatory properties, their effects on h2o2-stimulated macrophages are a novel area of study.201425075197
neuroprotective effects of arctium lappa l. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, jnk and erk 1/2 mapks in pc12 cells.many studies have shown that glutamate-induced oxidative stress can lead to neuronal cell death involved in the development of neurodegenerative diseases. in this work, protective effects of ethyl acetate extract (eae) of arctium lappa l. roots against glutamate-induced oxidative stress in pc12 cells were evaluated. also, the effects of eae on antioxidant system, mitochondrial pathway, and signal transduction pathway were explored. pretreatment with eae significantly increased cell viability, ac ...201424956398
chemical analysis and antihyperglycemic activity of an original extract from burdock root (arctium lappa).in the present study, we obtained a dried burdock root extract (dbre) rich in caffeoylquinic acids derivatives. we performed the chemical characterization of dbre and explored its antihyperglycemic potential in both in vitro and in vivo experiments. chemical analysis of dbre using lc-ms and gc-ms revealed the presence of a great majority of dicaffeoylquinic acid derivatives (75.4%) of which 1,5-di-o-caffeoyl-4-o-maloylquinic acid represents 44% of the extract. in the in vitro experiments, dbre i ...201424933284
two new compounds from the fruits of arctium lappa.phytochemical investigation of the extract of arctii fructus led to the isolation and characterization of two new compounds, named arctiisesquineolignan b (1) and arctiiphenolglycoside a (2). their structures were elucidated by means of spectroscopic methods (uv, ir, hr-esi-ms, 1d and 2d nmr) and chemical evidence, as well as by comparison with known analogs in the literature. compound 2 exhibited stronger antioxidant activity than the positive control ascorbic acid at a concentration of 10 μm.201626981771
effects of arctium lappa on cadmium-induced damage to the testis and epididymis of adult wistar rats.the protective role of arctium lappa (al) on the testes of rats acutely exposed to cadmium (cd) was tested. the rats were randomly divided into a control group (c-group) and three major experimental groups, which were further subdivided into minor groups (n = 6) according to the experimental period (7 or 56 days). the c-group was subdivided into c-7 and c-56 [receiving a single saline solution, intraperitoneal (i.p.), on the first day]; the al-group, al-7, and al-56, received al extract (300 mg/ ...201626926909
protective effects of arctium lappa l. root extracts (ares) on high fat diet induced quail atherosclerosis.this study was designed to evaluate the protective effects of arctium lappa l. root extracts (ares) from different extraction methods (aqueous, ethanol, chloroform and flavone) on atherosclerosis.201626746431
inhibitory effect of fermented arctium lappa fruit extract on the ige-mediated allergic response in rbl‑2h3 cells.arctium lappa fruit has been used in traditional medicine, and it is known to exert beneficial effects, such as antioxidant, anti-inflammatory and anticancer effects. however, the effects of the arctium lappa fruit on the allergic response remain unknown. in this study, we evaluated the anti-allergic effects of arctium lappa fruit extract (afe) and its fermented form (f-afe) using immunoglobulin e (ige)-activated rbl‑2h3 cells. to investigate the anti-allergic effects of afe or f-afe, we examine ...201626707911
arctigenin reduces blood pressure by modulation of nitric oxide synthase and nadph oxidase expression in spontaneously hypertensive rats.arctigenin is a bioactive constituent from dried seeds of arctium lappa l., which was traditionally used as medicine. arctigenin exhibits various bioactivities, but its effects on blood pressure regulation are still not widely studied. in this study, we investigated antihypertensive effects of arctigenin by long-term treatment in spontaneously hypertensive rats (shrs). arctigenin (50 mg/kg) or vehicle was administered to shrs or wistar rats as negative control by oral gavage once a day for total ...201526585490
new butyrolactone type lignans from arctii fructus and their anti-inflammatory activities.arctiidilactone (1), a novel rare butyrolactone lignan with a 6-carboxyl-2-pyrone moiety, and 11 new butyrolactone lignans (2-12) were isolated from the fruits of arctium lappa l., together with 5 known compounds (13-17). their structures were elucidated by interpretation of their spectroscopic data (1d and 2d nmr, uv, ir, ord, and hresims) and comparison to literature data. the absolute configurations of compounds 1-12 were determined by a combination of rotating-frame nuclear overhauser effect ...201526312555
natural lignans from arctium lappa as antiaging agents in caenorhabditis elegans.arctium lappa is a well-known traditional medicinal plant in china (tcm) and europe that has been used for thousands of years to treat arthritis, baldness or cancer. the plant produces lignans as secondary metabolites, which have a wide range of bioactivities. yet, their antiaging potential has not been explored. in this study, we isolated six lignans from a. lappa seeds, namely arctigenin, matairesinol, arctiin, (iso)lappaol a, lappaol c, and lappaol f. the antioxidant and antiaging properties ...201526141518
compound mqa, a caffeoylquinic acid derivative, protects against nmda-induced neurotoxicity and potential mechanisms in vitro.compound mqa (1,5-o-dicaffeoyl-3-o-[4-malic acid methyl ester]-quinic acid) is a natural derivative of caffeoylquinic acid isolated from arctium lappa l. roots. however, we know little about the effects of mqa on the central nervous system. this study aims to investigate the neuroprotective effects and underlying mechanisms of mqa against the neurotoxicity of n-methyl-d-aspartate (nmda).201526096046
[spectrum-effect relationship between total antioxidant activity and hplc fingerprint of arctium lappa root].to explore the spectrum-effect relationship between the hplc fingerprint of arctium lappa root methanol extract and the total antioxidant activity.201426080501
arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of th1 and th17 cells via an mtorc1-dependent pathway.arctigenin, the main effective constituent of arctium lappa l. fruit, has previously been proven to dramatically attenuate dextran sulfate sodium (dss)-induced colitis in mice, a frequently used animal model of inflammatory bowel disease (ibd). as th1 and th17 cells play a crucial role in the pathogenesis of ibd, the present study addressed whether and how arctigenin exerted anti-colitis efficacy by interfering with the differentiation and activation of th1/th17 cells. in vitro, arctigenin was s ...201526074264
effects of hydro-alcoholic extract from arctium lappa l. (burdock) root on gonadotropins, testosterone, and sperm count and viability in male mice with nicotinamide/ streptozotocin-induced type 2 diabetes.reproductive dysfunction is a complication of diabetes. arctium lappa (burdock) root has hypoglycemic and antioxidative properties, which are traditionally used for treatment of impotence and sterility. therefore, the aim of this study is to investigate the effects of its hydro alcoholic extract on gonadotropin, testosterone, and sperm parameters in nicotinamide/ streptozotocin-induced diabetic mice.201726023292
natural lignans from arctium lappa modulate p-glycoprotein efflux function in multidrug resistant cancer cells.arctium lappa is a well-known traditional medicinal plant in china (tcm) and europe that has been used for thousands of years to treat arthritis, baldness or cancer. the plant produces lignans as secondary metabolites which have a wide range of bioactivities. yet, their ability to reverse multidrug resistance (mdr) in cancer cells has not been explored. in this study, we isolated six lignans from a. lappa seeds, namely arctigenin, matairesinol, arctiin, (iso)lappaol a, lappaol c, and lappaol f. ...201525765837
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