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antihypertensive effect of sesamin. iii. protection against development and maintenance of hypertension in stroke-prone spontaneously hypertensive rats.the antihypertensive effect of sesamin, a lignan from sesame oil, was examined using salt-loaded and unloaded stroke-prone spontaneously hypertensive rats (shrsp). the animals at 6 weeks of age were separated into a salt-loaded group and an unloaded group. salt-loaded animals were maintained on 1% nacl drinking water. each group was further divided into two groups: normal-diet group and sesamin-diet group. systolic blood pressure of all animals was monitored once weekly. at the end of the feedin ...19989635502
successful treatment of severe atopic dermatitis-complicated cataract and male infertility with a natural product antioxidant.there has been a recent dramatic change in the features of atopic dermatitis and male infertility, including a marked increased prevalence of severe and treatment-resistant atopic dermatitis; an increase in severe atopic dermatitis complicated by cataracts, especially in urban and industrial areas; and an increase in the number of infertile men with poor sperm motility. previously we have attributed these changes to the increased free radicals produced by environmental toxicity. we have reported ...19989638503
effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats.in a previous study, we showed that dietary gamma-linolenic acid (gla), an omega-6 polyunsaturated fatty acid found in borage oil (bor), attenuates the development of hypertension in young spontaneously hypertensive rats (shr). the purpose of this study was to determine the effects of dietary gla on established hypertension in adult rats, as well as its effects on components of the renin-angiotensin-aldosterone axis. for 5 weeks, male shr (14-15 weeks old) were fed a basal fat-free diet to which ...19989648942
the metabolism and n-6/n-3 ratio of essential fatty acids in rats: effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin).in this study, we examined the effect of dietary arachidonic acid (aa) and sesame lignans on the content and n-6/n-3 ratio of polyunsaturated fatty acid (pufa) in rat liver and the concentrations of triglyceride (tg) and ketone bodies in serum. for 4 wk, rats were fed two types of dietary oils: (i) the control oil diet groups (co and cos): soybean oil/perilla oil = 5:1, and (ii) the aa-rich oil group (ao and aos): aa ethyl esters/palm oil/perilla oil = 2:2:1, with (cos and aos) or without (co an ...19989655371
molecular characterization and interviral homologies of a potyvirus infecting sesame (sesamum indicum) in georgia.phylogenetic analyses of the 3' terminal region of a potyvirus naturally infecting sesame (sesamum indicum) in georgia indicated that the virus belongs to the passionfruit woodiness potyvirus subgroup, and is most closely related to cowpea aphid-borne mosaic potyvirus (cabmv) and south african passiflora potyvirus. based on the sequence identity, this virus is a strain of cabmv. use of degenerate primers, reverse transcription-polymerase chain reaction, cloning and sequence analysis allowed us t ...19979672651
effects of adrenal steroids on basal ganglia neuropeptide mrna and tyrosine hydroxylase radioimmunoreactive levels in the adrenalectomized rat.to investigate the effects of type i (mineralocorticoid) and type ii (glucocorticoid) receptor activation on striatal neuropeptide [preproenkephalin (ppe), preprotachykinin (ppt), and preprodynorphin (dyn)] mrna and midbrain cholecystokinin (cck) mrna as well as striatal tyrosine hydroxylase radioimmunoreactivity (th-ric) levels, we administered either replacement levels of corticosterone (cort; 0.5 mg/kg/day, s.c.) or pharmacological levels of deoxycorticosterone acetate (doca; a mineralocortic ...19989681476
testosterone differentially regulates expression of gnrh messenger rnas in the terminal nerve, preoptic and midbrain of male tilapia.the purpose of the present study was to examine the regulation of three molecular variants of gonadotropin-releasing hormone (gnrh)-encoding mrnas by testosterone in the male tilapia oreochromis niloticus. tilapias castrated for two weeks were injected intraperitoneally with sesame oil or 5 microgram/g testosterone for 7 days. in situ hybridization histochemistry was performed using 35s-labelled 30-mer antisense oligonucleotide probes complementary to exon two (bases 1-30) of salmon-, seabream-, ...19989748480
17beta-estradiol alters isoproterenol-induced relaxation in rat aortic rings.female wistar rats were treated with 17beta-estradiol (e2) (10 microg, s.c.) or with sesame oil for 3 days. the relaxation induced by isoproterenol (10(-9)-3 x 10(-6) m) in aortae precontracted with norepinephrine was significantly suppressed in aortae from e2-treated rats compared with the relaxation in those from control rats. n(g)-nitro-l-arginine, a nitric oxide synthase inhibitor, inhibited isoproterenol-induced relaxation in aortae from both e2-treated and control rats. metyrapone, a cytoc ...19989749933
the roles of depot injection sites and proximal lymph nodes in the presystemic absorption of fluphenazine decanoate and fluphenazine: ex vivo experiments in rats.the release and presystemic absorption of fluphenazine and its decanoate ester from intramuscular depots were investigated.19989755905
oral dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid.the pathophysiologic basis of tardive dyskinesia remains unclear. it has been proposed that tardive dyskinesia may be a result of excitotoxic neurodegeneration in the striatum caused by a neuroleptic-induced increase in striatal glutamate release and impaired energy metabolism. to investigate this hypothesis, haloperidol decanoate (38 mg/kg/four weeks intramuscularly) and the succinate dehydrogenase inhibitor 3-nitropropionic acid (8 mg/kg/day via subcutaneous osmotic mini-pumps), were administe ...19989758230
effect of american ginseng (panax quinquefolium) on male copulatory behavior in the rat.the effects of american ginseng (panax quinquefolium) on male rat copulatory behavior were investigated. adult sprague-dawley rats were administered either 10, 50 or 100 mg/kg of panax quinquefolium or a sesame oil vehicle per os (p.o.) for 28 days and copulatory behavior parameters were measured. ginseng-treated male rats demonstrated a significant decrease in mount, intromission and ejaculation latencies compared to vehicle controls. hormone analyses revealed no difference in plasma luteinizin ...19989761217
prenatal tcdd and predisposition to mammary cancer in the rat.prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) was investigated for its potential to predispose to breast cancer. analysis of mammary gland differentiation and cell proliferation were used as biomarkers. timed pregnant sprague-dawley cd rats were gavaged with 1 microg tcdd/kg on day 15 post-conception. control animals were treated with the same volume of vehicle (sesame oil) on the same schedule. mammary gland differentiation studies revealed that prenatal tcdd treatment, as com ...19989771934
comparison testing of the irritancy of children's liquid bubble bath using a modified human repeat insult patch test.bubble baths are common products used by parents with young children. some dermatologists and pediatricians do not recommend the use of these products.19989810021
food constituents attenuate monoamine oxidase activity and peroxide levels in c6 astrocyte cells.glial cell monoamine oxidase (mao) activity has been implicated as a contributor to oxidative neuronal damage associated with various neurodegenerative diseases. the attenuation of mao activity may provide protection against oxidative neurodegeneration. in this investigation, the presence of mao-b in rat c6 astrocyte cells was substantiated by dose-dependent inhibition of enzyme activity in the presence of chlorgyline-hcl and l-deprenyl. the present study evaluated various dietary-derived food c ...19989810264
identification of hidden allergens within foods.the problem of the detection of "hidden" allergens in food is a major concern for both the industry and consumers at present. the production of specific antibodies against two such food components, peanut and sesame, is described. immunoassays are presently the method of choice for detection and identification of a wide range of food components, and elisas (enzyme-linked immunosorbent assays) for both peanut and sesame have been set up. who might use such assays for maximum benefit, and in what ...19989826014
effect of dietary fats and sesamin on the lipid metabolism and immune function of sprague-dawley rats.we examined the effect of three dietary fats, safflower oil (saf) rich in linoleic acid, borage oil (bor) rich in gamma-linolenic acid, and perilla oil (per) rich in alpha-linolenic acid, on the lipid metabolism, and chemical mediator and immunoglobulin levels in sprague-dawley rats, as well as the dietary effect of sesame-derived antioxidative sesamin. the serum cholesterol, phospholipid, triglyceride, prostaglandin e2 level and splenic leukotriene b4 level were lower in the rats fed on bor or ...19989836427
quantitative in situ hybridization of three gonadotropin-releasing hormone-encoding mrnas in castrated and progesterone-treated male tilapia.we investigated the effects of castration and progesterone administration on the three gonadotropin-releasing hormone (gnrh)-encoding mrnas in sexually mature male tilapia oreochromis niloticus. in situ hybridization histochemistry was performed using 35s-labeled antisense oligonucleotide probes complementary to salmon-, seabream-, and chicken ii-gnrh cdnas to quantify cellular gnrh mrna expression in the terminal nerve ganglia (nucleus olfactoretinalis), preoptic area, and midbrain tegmentum of ...19989843646
hyperphagia in pre-fed rats following oral delta9-thc.using a pre-feed paradigm, the effects of orally-administered delta9-tetrahydrocannabinol (thc) on low baseline levels of nocturnal feeding were assessed. following 2-h access to a palatable wet mash diet at dark onset, adult male lister hooded rats (charles river) were treated with either sesame seed oil vehicle or delta9- tetrahydrocannabinol (0.063, 0.12, 0.25, 0.5, 1.0, or 2.0 mg/kg). one hour later, rats were allowed ad libitum access to standard chow, and intakes were monitored over the su ...19989855485
effects of ageing and oestrogen on the localization of immunoglobulin-containing cells in the chicken ovary.immunoglobulins in the chicken ovary are important for transfer of immunity to chicks through the egg and for protection of the ovary from infection. the aim of this study was to examine the effects of ageing and oestrogen on the population of ig-containing cells in the chicken ovary. the ovarian tissue of immature, young laying and old laying hens and that of immature birds treated with diethylstilboestrol (des), progesterone or sesame oil (vehicle) was processed for paraffin wax sections. the ...19989875150
pregnancy and steroid hormones enhance the vasodilation responses to cgrp in rats.we recently reported that calcitonin gene-related peptide (cgrp) reversed the hypertension induced by nitric oxide inhibition in pregnant rats and that this effect appeared to be progesterone dependent. in the present study, we examined whether the vasodilator responses to cgrp are increased during pregnancy and whether these responses are steroid hormone dependent. three groups of ovariectomized (ovx) rats (n = 4-8 rats/group) were studied 3 days after daily treatment (subcutaneous injection) w ...19999887042
cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures.antiseizure effects of progesterone (p) and its metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha, 5alpha-thp) were investigated following continuous vs. discontinuous p exposure. in experiments 1, 32 cycling long-evans rats were administered kainic acid (32 mg/kg sc), ictal behavior was examined, and plasma 3alpha,5alpha-thp levels were measured by radioimmunoassay. proestrus/estrus rats showed less ictal activity and had elevated 3alpha,5alpha-thp levels prior to kainic acid compared to dies ...19999972699
assessment of polystyrene extract for estrogenic activity in the rat uterotrophic model and an in vitro recombinant receptor reporter gene assay.the purpose of the study was to determine whether polystyrene used in food-contact applications would elicit an estrogenic response when extracts simulating exaggerated conditions of use were subjected to in vivo and in vitro tests. a sample of polystyrene was subjected to extraction conditions that simulate, or exaggerate, the actual food-contact uses of polystyrene to maximize the amount of low molecular weight polystyrene extractables. the food-simulating solvent and the time and temperature ...199810028405
effect of glucuronidation substrates/inhibitors on n-(3,5-dichlorophenyl)succinimide nephrotoxicity in fischer 344 rats.the agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) is an acute nephrotoxicant in rats. our previous studies have strongly suggested that glucuronide conjugation of ndps metabolites might be a bioactivation step mediating ndps nephrotoxicity. in this study, effects of substrates and/or inhibitors of primarily glucuronidation on ndps nephrotoxicity were examined to explore further the role of glucuronidation in ndps nephrotoxicity. male fischer 344 rats (4-6/group) were administer ...199910199580
pharmacokinetics and pharmacodynamics of qinghaosu derivatives: how do they impact on the choice of drug and the dosage regimens?the critical decisions of which artemisinin derivative(s) to use and by which route(s) of administration for falciparum malaria are complex scientifically and politically. despite the need for additional pharmacokinetic, pharmacodynamic and toxicokinetic data, these drugs are too important to delay concise, rational recommendations any longer. these types of decisions must be made now, implemented on a multinational level with who leadership, and revised as new findings emerge. for acute, uncomp ...199810212896
the neurosteroids dhea and dheas may influence cognitive performance by altering affective state.the effects of dehydroepiandrosterone (dhea) and its sulfate ester, dehydroepiandrosterone sulfate (dheas) on performance in various cognitive and affective tasks were investigated. ovariectomized rats (n = 48) received 0.0, 3.0, or 7.5 mg/kg s.c. of dhea or dheas suspended in 10% ethanol/sesame oil v/v. for the cognitive tasks (water maze, y-maze, passive avoidance, and object recognition), subjects were injected after training trials. for the affective tasks (tail flick, open field, and elevat ...199910222477
[oxidative injury and its defense system in vivo].we and other researchers verified that excessively produced free radicals by neutrophils induce various diseases such as behçet's disease, mcls, sle (neutrophil-stimulated lymphocytes), ra (synovial fluid neutrophils), crohn's disease, colitis ulcerosa, and dermatitis herpetiformis (dühring). recently, it was reported that environmental toxic agents including herbicides such as paraquat, insecticides, nitrogen oxide, and ultraviolet radiation produce free radicals. nitrogen oxide, a main product ...199910228384
estrus synchronization of beef cattle with a combination of melengestrol acetate and an injection of progesterone and 17beta-estradiol.our hypothesis was that estrus synchronization in beef cattle using melengestrol acetate (mga) and an injection of progesterone (p4) and 17beta-estradiol (e2) to regress dominant ovarian follicles would improve pregnancy rate (number conceived/number in group) to ai compared with feeding only mga or injecting pgf2alpha. during 2 yr, peripubertal heifers (n = 52) and cows (n = 327) received either 1) mga for 18 d (d 0 = 1st d of mga) plus an injection of p4 and e2 in sesame oil (vehicle) on d 11 ...199910229369
effect of sulfation substrates/inhibitors on n-(3,5-dichlorophenyl)succinimide nephrotoxocity in fischer 344 rats.the agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) is an acute nephrotoxicant in rats. our previous studies suggested that sulfate conjugation of ndps metabolites might be a bioactivation step mediating ndps nephrotoxicity. in this study, effects of substrates and/or inhibitors of sulfation on ndps nephrotoxicity were examined to explore further the role of sulfation in ndps nephrotoxicity. male fischer rats (4-8/group) were administered one of the following intraperitoneal (ip) ...199910321901
evidence of sex reversal in the gonads of chicken embryos after oestrogen treatment as detected by expression of lutropin receptor.in chicken embryos, there is a difference between the sexes in the onset of lutropin receptor mrna expression in the gonads. the effects of oestrogen on lutropin receptor expression were studied to investigate the mechanism controlling this difference. lutropin receptor mrna expression was detected in the ovaries of sesame oil-treated control female embryos on day 12 of incubation, while no expression was found in the testes of the male controls. oestradiol administration to genetically male emb ...199910341717
quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment.the binding characteristics of the relaxin receptor in rat atria, uterus and cortex were studied using a [33p]-labelled human gene 2 relaxin (b33) and quantitative receptor autoradiography. the binding kinetics of [33p]-human gene 2 relaxin (b33) were investigated in slide-mounted rat atrial sections. the binding achieved equilibrium after 60 min incubation at room temperature (23+/-1 degrees c) and dissociated slowly. the association and dissociation rate constants were 4.31+/-0.34x10(8) m(-1) ...199910369460
support for a bimodal role for type ii adrenal steroid receptors in spatial memory.we investigated the effects of acute adrenal steroid treatment on spatial memory using the y-maze and employing adrenal steroid receptor antagonists and agonists. for receptor activation, adrenalectomized rats were injected 2 h prior to their first y-maze trial with sesame oil (adrenalectomy or sham), stress levels of corticosterone, a type i receptor agonist (aldosterone), or a type ii receptor agonist (ru362). for receptor inactivation, unoperated rats were injected with a type i receptor anta ...199910371714
long term feeding effects of heated and fried oils on lipids and lipoproteins in rats.long term feeding effects (20 weeks) of heated and fried oils at 5 and 20% level in the diet on growth, plasma and tissue lipids were studied in rats. three vegetable oils of widespread usage viz., peanut oil, sesame oil and coconut oil with varying saturation and unsaturation were chosen for the study. no significant difference in growth rate, feed efficiency ratio, and liver weights were observed. higher plasma cholesterol levels were observed in heated oil fed group of rats compared to corres ...199910395078
the metabolism and distribution of sesame lignans (sesamin and episesamin) in rats.in this study, we examined the distribution and metabolism of refined sesame oil lignans (sesamin and episesamin) in rat. for 8 wk rats were fed the diet including 0.5% (w/w) sesame lignans (sesamin and episesamin) with 5% (w/w) corn oil or eicosapentaenoic acid (epa)-rich oil. the concentrations of sesamin and episesamin in rat liver after their administration for 8 wk were very low; both of them were less than 0.5 microgram/g liver. these were observed in both oil groups although the fatty aci ...199910405978
anaphylactic reaction to young garlic.garlic is well known to cause contact dermatitis and asthma. however, it is a very rare cause of food allergy. we present the case of a 23-year-old woman with previous history of allergy to pollen and dried fruit, and food-dependent, exercise-induced anaphylaxis for which no specific food could be identified as responsible, who experienced an anaphylactic reaction after eating young garlic.199910435479
two-generation reproduction study of lewisite in rats.lewisite, a potent toxic vesicant and chemical warfare agent, is used in a number of research laboratories, is stored in large quantities at depot sites throughout the usa and is occasionally transported to distant sites. thus, the potential for environmental or occupational exposure exists where lewisite is present. a 42-week two-generation study was conducted to determine the reproductive consequences of lewisite in parental male and female rats and their offspring. rats were administered lewi ...199910439336
effects of estrogen on autotomy in normal and ovariectomized rats.gonadal hormones may modulate analgesia responses induced by acute stress in humans and rats. to evaluate the effects of gonadal hormones in modifying neuropathic pain, we measured autotomy changes following sciatic nerve resection in ovariectomized rats and in the presence of estrogen replacement. two groups of female rats were subjected to ovariectomy and sham surgery. each group was then divided into two subgroups receiving subcutaneously sesame oil with or without estradiol benzoate (5 micro ...199910450069
cyclic estradiol treatment normalizes body weight and test meal size in ovariectomized rats.we tested whether cyclic estradiol treatment, like continuous estradiol treatment, is sufficient to normalize meal size and body weight in ovariectomized rats. in experiment 1, adult long-evans rats were ovariectomized and subcutaneously injected with 0, 0.2, or 2.0 microg estradiol benzoate (eb) in sesame oil each tuesday and wednesday. oil-treated ovariectomized rats gained more weight during 4 weeks of ad lib feeding (48 +/- 5 g) than intact rats (16 +/- 1 g, p < 0.01). cyclic treatment with ...199910463640
dietary defatted sesame flour decreases susceptibility to oxidative stress in hypercholesterolemic rabbits.plant glucosides possess antioxidative properties due to their ability to scavenge free radicals. sesame seeds contain a class of these compounds, the sesaminol glucosides. to evaluate their antioxidative activity in vivo, we fed rabbits diets containing 1% cholesterol (chol) with or without 10% defatted sesame flour (dsf) (containing 1% sesaminol glucosides) for 90 d. we determined the susceptibility of their tissues to oxidation ex vivo as well as serum total cholesterol (tc), phospholipid (pl ...199910498763
sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat.the effects of sesamin, one of the most abundant lignans in sesame seed, on hepatic fatty acid oxidation were examined in rats that were fed experimental diets containing various amounts (0%, 0.1%, 0.2%, and 0.5%) of sesamin (a 1:1 mixture of sesamin and episesamin) for 15 days. dietary sesamin dose-dependently increased both mitochondrial and peroxisomal palmitoyl-coenzyme a (coa) oxidation rates. mitochondrial activity almost doubled in rats on the 0.5% sesamin diet. peroxisomal activity incre ...199910535395
cloning and secondary structure analysis of caleosin, a unique calcium-binding protein in oil bodies of plant seeds.plant seed oil bodies comprise a matrix of triacylglycerols surrounded by a monolayer of phospholipids embedded with abundant oleosins and some minor proteins. three minor proteins, temporarily termed sops 1-3, have been identified in sesame oil bodies. a cdna sequence of sop1 was obtained by pcr cloning using degenerate primers derived from two partial amino acid sequences, and subsequently confirmed via immunological recognition of its over-expressed protein in escherichia coli. alignment with ...199910589521
acute high dose arteether toxicity in rats.acute high dose administration of the artemisinin antimalarial, beta-arteether (ae), was evaluated in rats using an auditory discrimination task (adt) and histology. after rats were trained on the adt, ae (25, 75, 125 mg/kg, i.m.) or vehicle (sesame oil) was administered and behavioral performance was evaluated for 11 consecutive days. histological evaluation of the brains was performed using thionine and cupric-silver staining. damaged cells were counted in specific brainstem nuclei of all rats ...199910591521
progesterone and prostaglandin h synthase-2 involvement in alcohol-induced preterm birth in mice.recently, an association between alcohol consumption during pregnancy and shortened gestational length has been reported, but the underlying mechanisms remain unknown. progesterone (p4) and prostaglandins have been shown to play important roles in parturition in both human and animal models. recently, it has been suggested that prostaglandin h synthase-2 (pghs-2) is responsible for prostaglandin changes associated with term and preterm labor. it is possible that alcohol induces preterm birth by ...199910591596
sodium sulfate potentiates n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs) and n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-ndhsa) nephrotoxicity in the fischer 344 rat.the agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) induces nephrotoxicity as its major toxicity in rats. previous studies have shown that ndps induces nephrotoxicity following oxidation of the succinimide ring to form n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs) and the hydrolysis product of ndhs, n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-ndhsa). our recent work found that sodium sulfate potentiated ndps nephrotoxicity, suggesting that sulfate conjugation of ndps ...199910593507
molecular cloning of 11s globulin and 2s albumin, the two major seed storage proteins in sesame.insoluble 11s globulin and soluble 2s albumin, conventionally termed alpha-globulin and beta-globulin, are the two major storage proteins and constitute 80-90% of total seed proteins in sesame. two full-length cdna clones were sequenced and deduced to encode sesame 11s globulin and 2s albumin precursors, respectively. deduced amino acid composition reveals that 2s albumin, but not 11s globulin, is a sulfur-rich protein. three abundant polypeptides of 50-60 kda were resolved on sds-page when seed ...199910606554
effect of estradiol on estrogen receptor expression in rat uterine cell types.in rodent uterus, both up- and down-regulation of estrogen receptor alpha (eralpha) messenger ribonucleic acid (mrna) and protein levels by estradiol has been demonstrated; however, it is not known which of the uterine compartments (endometrial epithelium, stroma, myometrium) respond to estradiol with autoregulation of eralpha. the purpose of the present study was to investigate and compare the kinetics and cell type-specific effects of estradiol on uterine eralpha expression in immature and adu ...200010611082
perinatal exposure to estrogenic compounds and the subsequent effects on the prostate of the adult rat: evaluation of inflammation in the ventral and lateral lobes.although the effects of estrogenic compounds administered during the perinatal period on the size and morphology of the prostate have been well documented, the effects of such exposures on inflammatory changes in the prostate have not been well characterized. since neonatal estradiol exposure has been shown to cause periods of hyperprolactinemia later in life and a relationship exists between high prolactin levels and rat lateral prostate inflammation, we hypothesized that an exposure to environ ...199910613394
subcutaneous oleomas induced by self-injection of sesame seed oil for muscle augmentation.this case presentation describes a 48-year-old man who experienced subcutaneous nodules 9 months after self-injection of sesame seed oil into the pectoral area for muscle augmentation. this procedure was reported by our patient to be frequently performed in the body-building and fitness scene. ultrasound imaging showed multiple, low reflecting round nodular areas of up to 1 cm diameter in both breasts. excision of a representative nodule revealed a cyst filled with oily material, surrounded by g ...200010642691
production and evaluation of weaning foods based on sorghum and legumes.five weaning formulations (f1-f5) based on sorghum, groundnuts, sesame seeds, chickpeas, and skim milk powder were processed by a twin-roller drum dryer and evaluated for composition, functional properties (bulk density, water absorption capacity, and apparent viscosity), in vitro indices (protein digestibility and available lysine), protein quality (per, npr, and npu) and effects of feeding on rat livers. composition and properties of the five formulations were compared to those of cerelac. the ...199910646627
neuroleptic-induced striatal damage in rats: a study of antioxidant treatment using accelerometric and immunocytochemical methods.investigators have postulated that neuroleptic medications may affect the motor system through the creation of free radicals. also, structural brain changes related to oxidative damage may disrupt normal striatal function.200010663432
mode of action of sesame lignans in protecting low-density lipoprotein against oxidative damage in vitro.we investigated the antioxidant properties of sesaminol, a major component of sesame oil, on the oxidative modification of human low-density lipoprotein (ldl) in vitro. sesaminol inhibited the cu2+-induced lipid peroxidation in ldl in a concentration-dependent manner with an ic50 36.0 +/- 10.0 nm. sesaminol was a more effective scavenger than either alpha-tocopherol or probucol in reducing the peroxyl radicals derived from 2,2'-azobis (2-amidinopropane) dihydrochloride (aaph) in aqueous solution ...200010666012
nutritional evaluation of table bread fortified with defatted soybean and sesame meals.the nutritional value of table bread fortified with 8% defatted soybean meal (dsbm), 12% dsbm and a mixture of 8% dsbm/4% defatted sesame meal (dsm) was assessed with in vivo and in vitro tests. fortification with dsbm and dsm decreased protein digestibilities (p < 0.05) but improved essential amino acid scores (eaa) and overall nutritional value of the breads. fortified breads contained twice as much lysine, and consequently a better protein efficiency ratio (per) than the control bread. the pe ...199910667266
update from asia. asian studies on cancer chemoprevention.in asia, nontoxic dietary products are considered desirable primary prevention vehicles for conquering cancer. as early as 1978, investigators in korea carried out extensive long-term anticarcinogenicity experiments using the mouse lung tumor model and observed an anticarcinogenic effect of panax ginseng c.a. meyer extract in 1980. the results showed that natural products can provide hope for human cancer prevention. a newly established nine-week medium-term model using mouse lung tumors (yun's ...199910668493
a sandwich enzyme-linked immunosorbent assay for the detection of almonds in foods.an enzyme-linked immunosorbent assay was developed to detect almonds as potential allergenic contaminants in food. polyclonal antibodies directed against roasted almonds were partially purified from immunized sheep and rabbits and used as capture and secondary antibodies, respectively, in a sandwich-type, 96-well plate format. food samples and almond-spiked samples were extracted 1:10 in phosphate-buffered saline at 60 degrees c for 2 h, centrifuged, and applied to wells coated with sheep anti-a ...200010678432
functional evaluation of tadenan on micturition and experimental prostate growth induced with exogenous dihydrotestosterone.to evaluate the effect of tadenan (tad; pygeum africanum extract) pretreatment on the micturition characteristics of conscious and anesthetized rats consequent to dihydrotestosterone (dht) administration and to examine the influence of such treatment on the growth of the prostate.200010688098
estradiol enhances the induction of homosynaptic long-term depression in the ca1 region of the adult, ovariectomized rat.an ovarian steroid-dependent cycle of synaptogenesis and synapse shedding occurs naturally in the hippocampus of the adult female rat. the newly formed axospinous synapses in ca1 may differ functionally from extant axospinous synapses, e.g., in terms of their modifiability. here we assess whether estradiol alters the induction of homosynaptic long-term depression of the schaffer collateral-ca1 synapses in vitro. sprague-dawley rats were bilaterally ovariectomized and, beginning 6-8 days later, r ...200010704327
sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet.docosahexaenoic acid (dha) is an essential nutrient for human health, but has extremely high oxidative susceptibility. we examined the suppressing effect of sesamin, a sesame seed lignan, on lipidperoxides in rats fed a low alpha-tocopherol and high dha containing diet. groups of rats were fed four experimental diets: low alpha-tocopherol (10 mg/kg diet) control diet, low alpha-tocopherol + 0.2% sesamin diet, low alpha-tocopherol + 0.5% dha diet and low alpha-tocopherol + 0.5% dha + 0.2% sesamin ...200010705949
increased band 3 protein aggregation and anti-band 3 binding of erythrocyte membranes on treatment with sesamol.the influence of sesamol, an antioxidant in processed sesame oil, on oxidative modification of human erythrocyte membrane proteins was investigated. human erythrocytes were incubated with sesamol at various concentrations up to 10 mm at 37 degrees c for 1 h. the amounts of hemoglobin bound to the membranes and detergent c12e8-insoluble membrane protein aggregates were increased as the concentration of sesamol increased. western blot analysis indicated that aggregates of band 3 protein were incre ...200010706378
arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses.multiple doses of arteether (arte) at 25 mg/kg cause cns and anorectic toxicities in rats. the same dose of arte was used to study the toxicokinetics (tk) after multiple injections and the pharmacokinetics (pk) following single administration. animals were administered arte in sesame oil for 7 days, blood samples were collected using destructive sampling for up to 192 h after dosing and assayed by hplc-ecd. two other groups of rats were administered either a single 25 mg/kg i.v. or i.m. dose. in ...199910716059
decreased production of interleukin-6 and prostaglandin e2 associated with inhibition of delta-5 desaturation of omega6 fatty acids in mice fed safflower oil diets supplemented with sesamol.the differences in the immune responses in mice fed sesame oil diets and those fed sesamin may be attributed to the presence of other lignans in the non-fat portion of the oil. the fatty acid composition (mean +/- sd mol. %) of liver membrane phospholipids and the levels of endotoxin-induced prostaglandin (pg) e2, interleukin (il)-6, il-10, il-12 and tumor necrosis factor (tnf)-alpha were determined in mice fed diets supplemented with 5% safflower oil (so) in the absence or presence of 1% sesamo ...199910718106
suppressive effects of fish oil on mesangial cell proliferation in vitro and in vivo.mesangial cell proliferation is a characteristic feature of iga nephropathy and many other forms of glomerulonephritis. recent clinical studies have shown that dietary fish oil supplementation retards renal disease progression in patients with iga nephropathy. the mechanism by which this effect occurs is unknown.200010720955
characterization of the total free radical scavenger capacity of vegetable oils and oil fractions using 2,2-diphenyl-1-picrylhydrazyl radical.the total free radical scavenger capacity (rsc) of 57 edible oils from different sources was studied: olive (24 brands of oils), sunflower (6), safflower (2), rapeseed (3), soybean (3), linseed (2), corn (3), hazelnut (2), walnut (2), sesame (2), almond (2), mixture of oils for salad (2), "dietetic" oil (2), and peanut (2). olive oils were also studied according to their geographical origins (france, greece, italy, morocco, spain, and turkey). rsc was determined spectrophotometrically by measuri ...200010725129
anti-seizure effects of progesterone and 3alpha,5alpha-thp in kainic acid and perforant pathway models of epilepsy.the mechanism by which progesterone has its anti-seizure effects is unknown. progesterone has a high affinity for intracellular progestin receptors, but has weak actions at gamma-aminobutyric acid (gaba)(a) receptors complexes. the progesterone metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-thp) is devoid of activity at intracellular progestin receptors but is a highly effective modulator of gaba(a) receptor complexes. whether progesterones anti-seizure actions are due to effects of ...200010725616
regulation of calcitonin gene-related peptide expression in dorsal root ganglia of rats by female sex steroid hormones.calcitonin gene-related peptide (cgrp), a potent vasodilator primarily synthesized in dorsal root ganglia (drg) neurons, has been shown to decrease vascular resistance and thus regulate blood flow to a variety of organs in rats. serum cgrp levels in the human have been reported to increase with pregnancy and decrease postpartum. it has been suggested that female sex steroid hormones play a role in cardiovascular function, but the mechanisms are unknown. in this study, we examined the effects of ...200010727274
estrous cycle characteristics and response to estrus synchronization in mammoth asses (equus asinus americanus).breeding records from a herd of mammoth asses (equus asinus americanus) maintained on pasture in southeast texas from 1990 to 1998 were reviewed. jennies were pasture or hand mated, and estrus was either observed while the jennies were on pasture or when exposed to a jack after being penned. eighty-one estrus periods and 43 diestrus intervals were recorded in 33 jennies over 4 seasons of the year (january-march, april-june, july-september, and october-december). estrous cycle length and the dura ...199910735123
chronic electroconvulsive shock decreases (+/-) 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (doi)-induced wet-dog shake behaviors of dexamethasone-treated rats.electroconvulsive shock (ecs) therapy is considered to be an effective treatment for depression, but its mechanism of action is still unknown. we investigated the effect of chronic ecs in rats treated for 14 days with dexamethasone (dex), a glucocorticoid receptor agonist. chronic injection of sesame oil decreased body weight change and increased serotonin (5-ht)-2a receptor number and doi (5-ht-2a, 2c receptor agonist)-induced wet-dog shake (wds) behaviors. dex treatment for 14 days decreased b ...200010737422
effects of various tocopherol-containing diets on tocopherol secretion into bile.gamma-tocopherol is abundant in common vegetable oil, but its concentration in plasma and liver is much lower than that of alpha-tocopherol. discrimination between different forms of tocopherol is thought to take place via the hepatic alpha-tocopherol transfer protein (alpha-ttp). gamma-tocopherol, with a low binding capacity to alpha-ttp, is thought to be excreted via the bile. our previous studies showed that gamma-tocopherol administered with sesame seed exhibits significantly higher concentr ...200010757547
effect of estradiol-17beta administration during the time of conceptus elongation on placental size at term in meishan pigs.meishan embryos transferred to recipient females on d 2.5 are larger, contain greater numbers of trophectoderm cells, and secrete greater amounts of estradiol-17beta (e2beta) when gestated in a yorkshire as compared with meishan uterus to d 12. additionally, placentas of meishan conceptuses are larger when gestated in a yorkshire as compared with meishan uterus throughout gestation. embryonic e2beta secretion during elongation on d 12 to 13 of gestation is temporally associated with endometrial ...200010784197
bioavailability of iron from four different local food plants in jordan.the bioavailability of iron from local plants (black cumin seeds, milk thistle seeds, sesame seeds and thyme leaves) was investigated. apparent absorption of iron was calculated by subtracting fecal iron (using total collection of feces) from iron intake in sprague-dawley rats. two trials of animal feeding were performed. liver and serum concentrations of iron, and serum hemoglobin concentration were taken as response parameters for the bioavailability. dry thyme was particularly rich in iron (1 ...199910798339
thyroid hormone and estrogen regulate brain region-specific messenger ribonucleic acids encoding three gonadotropin-releasing hormone genes in sexually immature male fish, oreochromis niloticus.the present study was undertaken to determine whether t3, estrogen, and 11-ketotestosterone could alter a specific population of gnrh-containing neurons, as indicated by a change in messenger rna (mrna) levels in sexually immature male tilapia, oreochromis niloticus. two weeks after castration, fish were assigned to four treatment groups. one group served as the control (sesame oil); a single ip injection of (t3; 5 microg/g), estradiol benzoate (eb; 5 microg/g), or 11-ketotestosterone (kt; 5 mic ...200010803569
the effect of raloxifene on the uterine weight response in immature mice exposed to 17beta-estradiol, 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane, and methoxychlor.the purpose of this study was to determine the effects of raloxifene on the uterine responses to both estradiol and the environmental estrogens 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane and methoxychlor in immature mice. study design: immature female mice received the following compounds alone or in combination: sesame oil (control), 17beta-estradiol 1 mg/kg body weight, tamoxifen 1 mg/kg body weight, raloxifene 5 mg/kg body weight, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane 10 mg/kg bod ...200010819839
local versus systemic effects of exogenous estradiol-17 beta on ovarian follicular dynamics in heifers with progestogen implants.two experiments were designed to determine if the suppressive effect of estradiol treatment on ovarian follicles in progestogen-implanted heifers is mediated directly at the ovary or systemically, at a higher level. the purpose of experiment 1 was to determine a minimal effective dose of estradiol-17beta (e-17beta) that would induce follicle regression in progestogen-implanted heifers. beef heifers were implanted with progestogen on day 2 (day 0=ovulation) and were assigned randomly to five grou ...200010837975
arteether-induced brain injury in macaca mulatta. i. the precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei.malaria poses a threat across several continents: eurasia (asia and parts of eastern europe), africa, central and south america. bradley (1991) estimates human exposure at 2,073,000,000 with infection rates at 270,000,000, illnesses at 110,000,000, and deaths at 1,000,000. significant mortality rates are attributed to infection by the parasite plasmodium falciparum, with an estimated 90% among african children. a worldwide effort is ongoing to chemically and pharmacologically characterize a clas ...200010839633
microbial production of polyhydroxyalkanoates by bacteria isolated from oil wastes.a gram-positive coccus-shaped bacterium capable of synthesizing higher relative molecular weight (m(r)) poly-hydroxybutyrate (phb) was isolated from sesame oil and identified as staphylococcus epidermidis (by microbial id, inc., newark, nj). the experiment was conducted by shake flask fermentation culture using media containing fructose. cell growth up to a dry mass of 2.5 g/l and phb accumulation up to 15.02% of cell dry wt was observed. apart from using single carbohydrate as a sole carbon sou ...200010849842
sesamin and episesamin induce apoptosis in human lymphoid leukemia molt 4b cells.the exposure of human lymphoid leukemia molt 4b cells to sesamin and episesamin which were isolated from unroasted sesame seed oil and identified by ms, and 1h and 13c-nmr, led to both growth inhibition and the induction of programmed cell death (apoptosis). morphological change showing apoptotic bodies was observed in the molt 4b cells treated with sesamin and episesamin. the fragmentations by sesamin and episesamin of dna to oligonucleosomal-sized fragments that are characteristics of apoptosi ...200010851264
suppression of growth of cultured malignant cells by allomelanins, plant-produced melanins.allomelanins, which belong to the melanins produced by higher plants and fungi, were studied with respect to their growth suppressive effects on cultured hct-15 cells derived from human intestinal carcinoma and meth/a cells derived from a balb/c mouse lymphoma. allomelanins were extracted from black soy beans and black sesame seeds with 0.2% naoh in water. proteins bonded to the allomelanins were removed by boiling the extracts for 20 hours in 30% naoh. although native allomelanins conjugated wi ...199710851446
effect of allomelanin on tumor growth suppression in vivo and on the cell cycle phase.allomelanins are nitrogen-free macromolecular polymers of simple phenols produced by higher plants and fungi. in an earlier work we found that allomelanins were effective in suppressing the growth of cultured tumor cells. in the present study we examined the effect of these polymers on the survival curve of balb/c mice inoculated i.p. with meth/a cells (3 x 10(4) cells/mouse), which originated from a malignant lymphoma. allomelanins were extracted from black sesame seeds and black soybeans, and ...199710851475
horse racing, sesame seeds and hyenas on the web 200010858644
local effects of mifepristone on the nonhuman primate endometrium.to determine the effects of a low-dose mifepristone regimen on endometrium in the rhesus monkey by endometrial staging and analysis of molecular markers of endometrial receptivity.200010899510
effects of pregnancy and progesterone on the consumption of ethanol by the high ethanol preferring (hep) rat.a significant fraction of women continue to drink heavily during pregnancy, which is associated with the fetal alcohol syndrome, alcohol-related birth defects, alcohol-related neurodevelopmental disorder, and spontaneous abortion. the objective of this study was to determine whether the selectively bred genetic drinking myers high ethanol preferring (hep) rat would continue to drink through pregnancy. rats from the f7 generation were screened by a 10-day 3-30% (v/v) ethanol concentration 'step u ...200010905998
expression of estrogen receptor coactivators in the rat uterus.nuclear receptor coactivators associate in a ligand-dependent manner with estrogen receptors (er) and other nuclear receptors, and they enhance ligand-dependent transcriptional activation. this study examined basal coactivator expression in rat uterus to investigate if expression of these genes is regulated by estradiol-17 beta or tamoxifen. ovariectomized mature and immature rats were injected with estradiol-17 beta, tamoxifen, or vehicle (i.e., sesame oil) alone. uteri were collected and analy ...200010906038
effect of dietary oil intake on hepatic cytochrome p450 activity in the rat.the objective of the present study was to investigate whether or not different dietary oils, commonly used as drug vehicles, alter hepatic microsomal drug metabolism in the rat. male adult sprague-dawley rats were administered 1 ml/kg/d of either corn, olive, sesame, or soybean oil via oral gavage for 7 days. an additional rat group was given an equal volume of water each day to serve as a control. we found that the hepatic cytochrome p450 (cyp) 3a2 protein level increased by 16% (p < 0.01) in r ...200010906725
enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets.this study was conducted to determine a role for cortisol in regulating intestinal ornithine decarboxylase (odc) activity and to identify the metabolic sources of ornithine for intestinal polyamine synthesis in suckling pigs. thirty-two 21-day-old suckling pigs were randomly assigned to one of four groups with eight animals each and received daily intramuscular injections of vehicle solution (sesame oil; control), hydrocortisone 21-acetate (hyd; 25 mg/kg body wt), ru-486 (10 mg/kg body wt, a pot ...200010913040
dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity.androgen-receptor upregulation that occurs with androgenic-anabolic steroid (aas) administration may be mediated by aas metabolites, dihydrotestosterone (dht), and estrogen. castrated and intact male rats received 14 s.c. daily injections of aas (2 mg/kg testosterone cypionate, 2 mg/kg nandrolone decanoate, and 1 mg/kg boldenone undecylenate in sesame oil vehicle), dht (5 mg/kg dihydrotestosterone), eb (5 mg/kg estradiol benzoate), or sesame oil vehicle. approximately 18-24 h after the fourteent ...200010913783
treadmill exercise training augments brain norepinephrine response to familiar and novel stress.in a test of hypothalamic-pituitary-adrenal (hpa) cortical and hypothalamic-pituitary-gonadal (hpg) interaction during familiar and novel stress, we previously reported that treadmill exercise training led to blunted plasma adrenocorticotrophin (acth) response to acute treadmill running but a hyper-responsiveness of acth after novel immobilization. in this follow-up analysis, we examined whether those results might be plausibly explained by a similar effect of treadmill exercise training on incr ...200010922511
identification of a taurine transport inhibitory substance in sesame seeds.an ethanol extract from sesame seeds inhibited the taurine uptake in human intestinal epithelial caco-2 cells. the uptake of such alpha-amino acids as leucine and glutamic acid was not inhibited by the extract, indicating that this inhibition is specific to the taurine uptake. the unknown inhibitor in the sesame extract was purifled by reversed-phase hplc by monitoring the inhibitory effect on taurine uptake. the isolated substance was identified as lysophosphatidylcholine, linoleoyl (lyso-pc), ...200010923786
a cortisol surge mediates the enhanced polyamine synthesis in porcine enterocytes during weaning.this study was conducted to determine whether a cortisol surge mediates the enhanced expression of intestinal ornithine decarboxylase (odc) in weanling pigs. piglets were nursed by sows until 21 days of age, when 40 pigs were randomly assigned into one of four groups (10 animals/group). group 1 continued to be fed by sows, whereas groups 2-4 were weaned to a corn and soybean meal-based diet. weanling pigs received intramuscular injections of vehicle solvent (sesame oil), ru-486 (a potent blocker ...200010938245
androgens are neuroprotective in the dentate gyrus of adrenalectomized female rats.neuroprotective effects of androgens have not been well-characterized, but there is evidence that 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol) has anti-seizure effects. to further examine androgens' neuroprotective effects, testosterone (t), dihydrotestosterone (dht), 3 alpha-diol (1.0 mg/kg sc daily), or sesame oil vehicle was administered to adrenalectomized or sham-operated, young, female long evans rats (n = 52). after seven days, animals were perfused and trunk blood was collecte ...200010938579
possible estrogenic and/or antiandrogenic effects of methoxychlor on prolactin release in male rats.methoxychlor (mtx) is a pesticide currently used as a substitute for dichloro-diphenyl-trichloroethane (ddt). this organochloride insecticide has some estrogenic properties, and may modify the feedback mechanisms of steroids on the hypothalamus and pituitary. this work was undertaken to explore the possible effects of mtx on the episodic prolactin release and to analyze whether these effects are mediated by dopamine (da), luteinizing hormone (lh), and/or testosterone. adult male sprague-dawley r ...200010959802
effect of testosterone on the number of nadph diaphorase-stained nerve fibers in the rat corpus cavernosum and dorsal nerve.to elucidate the effect of testosterone on penile nerve supply.200010962339
effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor alpha in rats.sesamin, a nonfat constituent of sesame oil, inhibits delta(5)-desaturase activity, resulting in accumulation of dihomo-gamma-linolenic acid (dgla), which displaces arachidonic acid (aa) and consequently decreases the formation of proinflammatory 2-series prostaglandins.200010966903
experimental hyperprolactinemia in a rat model: alteration in centrally mediated neuroerectile mechanisms.the purpose of this study was to induce hyperprolactinemia in adult male rats and determine its effect on the central and peripheral mediated neurogenic as well as myogenic mechanisms of erectile function/dysfunction in a rat model. the use of penile reflexes in awake animals was used to test the effect of both central and peripheral mechanisms. electrical stimulation of the cavernous nervous was used to test peripheral neural function and intracorporal injection of papaverine was used to test t ...200010982309
sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity.the effects of sesamol, a phenolic compound responsible for the high resistance of sesame oil to oxidative deterioration as compared with other vegetable oils, have been investigated after mutagen treatment in various strains of salmonella typhimurium. sesamol was shown to exhibit strong antimutagenic effects in the ames tester strains ta100 and ta102. the ta102 strain has been shown to be highly sensitive to reactive oxygen species. mutagenicity was induced by the generation of oxygen radicals ...200010986476
luteinizing hormone secretion as affected by hypophyseal stalk transection and estradiol-17beta in ovariectomized gilts.the objectives were to determine hypothalamic regulation of pulsatile luteinizing hormone (lh) secretion in female pigs and the biphasic feedback actions of estradiol-17beta (e(2)-17beta). in the first study, the minimum effective dosage of e(2)-17beta that would induce estrus in ovariectomized gilts was determined to be 20microg/kg body weight. in the second study, ovariectomized gilts were assigned randomly on day 0 to treatments: (a) hypophyseal stalk transection (hst), (b) cranial sham-opera ...200010989235
effects of sesamin on altered vascular reactivity in aortic rings of deoxycorticosterone acetate-salt-induced hypertensive rat.the effect of sesamin, a lignan from sesame oil, on altered vasodilator and vasoconstrictor responses in aortic rings from deoxycorticosterone acetate (doca)-salt-induced hypertensive rats, were examined. the systolic blood pressure after 5-weeks doca-salt treatment was 195.0+/-2.8 mmhg, which was much higher than that of sham-operated control animals (131.2+/-2.4 mmhg). sesamin feeding significantly suppressed the development of this hypertension (167.1+/-8.6 mmhg). acetylcholine (ach)-induced ...200010993201
congenital anomalies in mice induced by etretinate.we report on the experimental induction of anorectal malformations (arm) and other internal and external malformations in mouse fetuses induced by maternal administration of etretinate, a long-acting vitamin a analogue. the teratogen was administered to pregnant mice between the 7th and 10th gestational days (e7 and e10). the mice of the control group were given pure sesame oil on e9. we examined survival rates, crown-rump length, and the incidence of internal and external malformations, with pa ...200011034515
effect of all-trans and 9-cis retinoic acid on growth and metastasis of xenotransplanted canine osteosarcoma cells in athymic mice.to determine effects of all-trans and 9-cis retinoic acid (ra) on tumor growth and metastatic ability of canine osteosarcoma cells transplanted into athymic (nude) mice.200011039554
cytochrome p4503a-dependent metabolism of tocopherols and inhibition by sesamin.carboxychroman metabolites of the major dietary tocopherols are excreted in human urine, but the mechanism of their synthesis is unknown. we employed well-characterized inhibitors of specific cytochrome p-450 (cyp) enzymes to determine which form was likely involved in tocopherol side chain oxidation. ketoconozole (1.0 microm), a potent and selective inhibitor of cyp3a, substantially inhibited metabolism of gamma- and alpha-tocopherol in rat primary hepatocytes, and metabolism of gamma- and delt ...200011061988
previous experience of diazepam withdrawal prevents the formation of a withdrawal-conditioned taste aversion: test of a blocking hypothesis.prior experience of withdrawal from chronic diazepam treatment reduces the aversiveness of withdrawal when precipitated withdrawal is made the unconditioned stimulus in a conditioned taste aversion (cta) paradigm. accounts of the mechanism by which unconditioned stimulus pre-exposure reduces its effectiveness in cta postulate that unconditioned stimulus pre-exposure leads to the formation of associations with the environment, resulting in blocking of taste conditioning. we tested whether a block ...200011103913
behavioral and neural toxicity of the artemisinin antimalarial, arteether, but not artesunate and artelinate, in rats.three artemisinin antimalarials, arteether (ae), artesunate (as), and artelinate (al) were evaluated in rats using an auditory discrimination task (adt) and neurohistology. after rats were trained on the adt, equimolar doses of ae (25 mg/kg, in sesame oil, n=6), as (31 mg/kg, in sodium carbonate, n=6), and al (36 mg/kg, in saline, n=6), or vehicle (sodium carbonate, n=6) were administered (im) for 7 consecutive days. behavioral performance was evaluated, during daily sessions, before, during, an ...200011113482
beneficial effects of flavonoids from sesamum indicum, emblica officinalis and momordica charantia.flavonoids from sesamum indicum (gingili), emblica officinalis (gooseberry) and momordica charantia (bittergourd) were analysed for their biological activities. of the three sources, flavonoids isolated from emblica officinalis exerted the maximum beneficial action by eliciting highly potent hypolipidaemic and hypoglycaemic activities. moreover these flavonoids were effective in raising the haemoglobin levels in rats.200011113993
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