| regulation of estrogen-induced uterine hyperemia and contractility in the guinea pig: cholinergic modulation of an alpha-adrenergic response. | the effects of estradiol (1 microgram: e-1) treatment on uterine hyperemia and uterine sensitivity to various biogenic compounds were evaluated in ovariectomized (ovx) animals treated with either sesame oil or e-1 for 3 days. the e-1 treatments induced significant elevations in uterine weight, blood flow, and alpha- and beta-receptor numbers as compared with oil-treated controls. in contrast, uterine norepinephrine (ne) levels were reduced in e-1-treated, ovx guinea pigs as compared with oil-tre ... | 1984 | 6329335 |
| a luteolytic interaction between estradiol benzoate and prostaglandin f2 alpha in cattle. | a possible luteolytic interaction between prostaglandin f2 alpha (pgf2 alpha) and estradiol benzoate (e2b) in cattle was investigated by randomly assigning 20 heifers to one of four groups of a 2 x 2 factorially designed experiment. the treatments for the groups consisted of im administration of: 1) 200 micrograms of e2b, given twice daily on d 10, 11 and 12 of the estrous cycle plus 7 mg pgf2 alpha, given at a separate site, but concurrently with the last injection of e2b; 2) the vehicles for e ... | 1983 | 6575009 |
| structural, functional and hypertensive effects of 19-oxo-11-deoxycorticosterone acetate (19-oxo-doca) in the rat. | mononephrectomized rats were given 1% nacl solution to drink; half of them received 1 mg/day of 19-oxo-11 deoxycorticosterone acetate (19-oxo-doca) in sesame oil subcutaneously and half received only the oil for a period of four weeks. the steroid had no effect upon saline intake, systolic blood pressure, growth or the size of adrenals, hearts or kidneys, although it did produce hypernatremia and hypokalemia. the discrepancy between a demonstrable mineralocorticoid effect without blood pressure ... | 1983 | 6658894 |
| role of the nongravid part of the uterus in the luteolytic effects of estrogen in pregnant rats. | effects of a low dose of estradiol on the luteal function were studied in intact pregnant rats. the pregnant rats received daily sc injections of 0.1 microgram estradiol or sesame oil from day 7 to 14 of pregnancy (day 1 = day of insemination). serum progesterone levels on day 15 were significantly lower in the estrogen-treated group than in the oil-treated group. in order to study how estrogen induced luteolysis, the pregnant rats received each of the following treatments on day 7 of pregnancy: ... | 1983 | 6671462 |
| [the physiological significance of the hippocampus on the inhibitory effects of corticosterone upon the estradiol-induced lh and fsh surges in rats]. | the effects of corticosterone (cs) on the gonadotropin surge induced by estradiol-benzoate (e2) were studied in adrenalectomized and ovariectomized (adrx-ovex) rats. the results are as follows. in adrx-ovex rats implanted with e2-tablets in the bilateral axillae, lh and fsh surges occurred 4 days after the implantation of e2, peaking at 17:00 h. the levels of these surges were markedly higher than those in ovex rats similarly treated but were attenuated significantly by the subcutaneous injectio ... | 1984 | 6440814 |
| the effect of steroids on the size heterogeneity of pituitary prolactin in castrate male rats. | male sprague-dawley rats were castrated and given daily sc. injections of estradiol (e2, 10 micrograms/day), testosterone propionate (tp, 1.0 mg/day), dihydrotestosterone (dht, 1.0 mg/day) or sesame oil (so, 0.2 ml/day). a group of sham castrate males received daily sc. injections of so (0.2 ml/day). on day 8 of steroid treatment animals were decapitated and anterior pituitaries were removed and hemisected. each half was homogenized in pbs buffer (0.01 m na2hpo4-nah2po4; 0.14 m nacl; 0.1% bovine ... | 1984 | 6694510 |
| pharmacokinetics of free catecholestrogens and catecholestrogen benzoates. | to provide a definite basis for studies on the biological effects of exogenously administered catecholestrogens, the time courses of the concentrations of these estrogens in serum, pituitary and cns-tissues were studied in male rats after s.c. injection of either 150 microgram of 4-hydroxyestradiol or 2-hydroxyestradiol (dissolved in 200 microliter sesame oil/ethanol/ascorbic acid; 97.5/2.5/0.1; vol/vol/wt) or equimolar amounts of 4-hydroxyestradiol 3, 4-dibenzoate or 2-hydroxyestradiol 2,3-dibe ... | 1982 | 6283699 |
| neonatal gonadal hormones and blood pressure in the spontaneously hypertensive rat. | in rats, gonadal steroid hormones present during the neonatal period produce permanent or "organizational" effects that play a role in the sexual differentiation of the brain and sexually dimorphic patterns of behavior. because there exists a sexually dimorphic pattern in the development of hypertension in the spontaneously hypertensive rat (shr), we examined the influence of neonatal gonadal hormones on arterial pressure and body weight in these rats. male shr rats were castrated or sham-operat ... | 1984 | 6465310 |
| estrogen-induced effects on food intake and body weight in ovariectomized, partially lipectomized rats. | following ovariectomy, rats were either partially lipectomized (10-15% of total body lipid was removed) or left intact, and were treated with either sesame oil vehicle or estradiol benzoate (eb; 4 micrograms/day) for 2 weeks. although lipectomy resulted in a change in carcass adiposity, robust behavioral and metabolic effects of eb were observed in all animals. eb treatment induced changes in all carcass components examined, including lipid, protein and water. lipid:protein ratios were not alter ... | 1984 | 6718535 |
| effect of vitamin e on ige antibody formation in mice. | effect of vitamin e (alpha-tocopheryl acetate and alpha-tocopheryl nicotinate) on ige antibody formation in mice was investgiated . female balb/c mice were immunized with dinitrophenylated ascaris protein (dnp-as) and aluminium hydroxide gel (alum). supplementation of vitamin e in diets or oral administration of vitamin e mixed with sesame oil resulted in a suppression of ige antibody formation. on the contrary to ige antibody formation, igm or igg (hemagglutinin; ha) formation was significantly ... | 1984 | 6726616 |
| in vivo incorporation of a cholesterol-like fluorescent probe into rat brain membranes. | the incorporation of the fluorescent sterol analog, cholesta-5,7,9-trien-3 beta-ol, into rat brain p2 fractions and its feasibility to detect membrane perturbations by polarization analysis were evaluated. this investigation involved the administration (i.c.v.) of the fluorescent compound in sesame oil with subsequent determination of optimal dose and the half-life of this compound within the membrane fraction. the dose giving maximum polarization was found to be 0.65 mumole, and pharmacokinetic ... | 1983 | 6314055 |
| [an extrarenal role of aldosterone on the regulation of blood pressure]. | this study was designed to examine the effects of aldosterone on the distribution of extracellular fluid between the intra- and extra-vascular compartments, and to relate the changes in the fluid distribution to blood pressure in nephrectomized and nephrectomized-adrenalectomized male wistar rats. polyethylene catheters were inserted into the right common carotid artery and the right jugular vein, and bilateral nephrectomy with or without adrenalectomy was performed. the animals were divided int ... | 1984 | 6489572 |
| the effect of depot parenteral zinc on copper metabolism in the rat. | the effect of depot parenteral injections of zinc (110 mg zn/kg body weight) on copper metabolism in young, male rats was investigated. individually caged rats, fed known amounts of stock diet and deionized-distilled water, were injected s.c. weekly for the first 4 weeks and biweekly for the next 17 weeks with zinc in sesame oil or the oil vehicle only. no significant differences in body weight, hemoglobin, hematocrit and fecal copper excretions were observed between treatments. however, 2 weeks ... | 1984 | 6502272 |
| the failure of glutamic acid to protect the rat embryo against the action of trypan blue. | the effect of l-glutamic acid on the embryolethal and teratogenic action of trypan blue was investigated in wistar albino rats. l-glutamic acid was either incorporated into the diet, from gestation day 2 to day 20, or suspended in sesame oil and administered by gavage, from gestation day 6 to day 10. the day of finding sperm in the vaginal smear was designated day 0 of pregnancy. a teratogenic dose of trypan blue was injected at day 8 of pregnancy, either intraperitoneally (14 mg/kg maternal bod ... | 1981 | 7245094 |
| brominated fatty acid distribution in tissues and fluids of rats fed brominated vegetable oils. | rats dosed orally for four days with 0.24 g/kg body weight per day of brominated olive oil (boo) or brominated sesame oil (bso) were found to accumulate dibromostearic (dbs) acid (from boo) and dbs and tetrabromostearic (tbs) acids (from bso) in the liver, heart and adipose tissue. the metabolites, dibromopalmitic, and dibromomyristic acids (from boo and bso), as well as their tetrabromo-analogues (from bso) were found as determined by gas chromatography with halogen specific detection and confi ... | 1984 | 6503632 |
| selenium and the genesis of murine mammary tumors. | one hundred forty-seven female sprague-dawley rats were divided into 5 groups and at 60 days of age were treated i.g. with 5 mg of 7,12-dimethylbenzanthracene (dmba) suspended in 1.0 ml of sesame oil. selenium (se), as selenium dioxide (seo2), was administered in the drinking water to 4 of the 5 groups (30 rats/group) at 2 doses (2 and 4 mg/l) from 30-90 days of age (series 1) and from 90-150 days of age (series 2) prior to the onset of palpable mammary tumors. one group of rats (27 rats) served ... | 1981 | 6791860 |
| the rate of absorption of synthetic lysine and dietary protein in the upper half of the small intestine of pigs. | the aim of the present work was to estimate the rate of lysine absorption in the upper part of the small intestine as related to the absorption of total nitrogen and other amino acids in pigs given feed (barley + sesame meal) supplemented with lysine and fed once or 4 times daily. the experiments were carried out on 6 pigs fitted with reentrant cannulas sited in 3 of them about 4 m and in an other 3 about 9 m distal to the pylorus (mean intestine length was about 18 m). the frequency of feeding ... | 1980 | 6793027 |
| role of ovarian steroid hormones in the regulation of adenylate cyclase during early progestation. | the hormonal regulation of uterine adenylate cyclase (ac) was measured in the rat by radiochemical analysis. animals made pseudopregnant by cervical stimulation were ovariectomized on day 1 (the first appearance of leukocytes in the vaginal smear) and injected for 6 days with sesame oil, 0.1-10.0 micrograms estrone, 2.0 mg progesterone, or 1.0 microgram estrone + 2.0 mg progesterone. ac activity in ovariectomized controls remained at basal levels (2.8-3.3 pmol camp formed/min x mg protein). the ... | 1984 | 6509140 |
| pituitary and ovarian responses to luteinizing hormone releasing hormone in a rat with polycystic ovaries. | female rats injected with a single dose of 2 mg estradiol valerate (ev) develop anovulatory acyclicity characterized by persistent vaginal cornification and the formation of multiple large cystic follicles on the ovaries. in order to determine if these effects of ev are accompanied by changes in ovarian and/or pituitary function, the following studies were conducted. ovarian androgen production was determined by the measurement at 4, 5 and 6 weeks after ev treatment of circulating dehydroepiandr ... | 1983 | 6351938 |
| studies on sesame oil cake meal (sesamum indicum) in chick mash. | | 1968 | 5693493 |
| selection of liver-colonizing tumor cells from a murine fibrosarcoma induced by methylcholanthrene. | an experimental tumor model was developed to study the organ preference of malignant tumors. the primary tumor er 15-p was induced by inoculation of 1 mg methylcholanthrene in 0.1 ml sesame oil into the left femoral muscle of a female c57/bl6j mouse. the tumor was palpable 100 days after induction. spontaneous lung metastases were found at autopsy on day 128. serial im transplantation of tumor cells from the primary er 15-p resulted in pulmonary metastases in all male and female mice. after iv i ... | 1984 | 6511801 |
| progesterone secretion as affected by 17 beta-estradiol after hysterectomy in the pig. | serum levels of progesterone in hysterectomized gilts were determined to evaluate the effects of exogenous 17 beta-estradiol (17 beta-e2) on the secretory activity of aging corpora lutea. gilts were hysterectomized on day 6 of the estrous cycle and given im injections of 17 beta-e2 to mimic blood levels of endogenous estrogen during normal pregnancy. serum progesterone was determined every third or sixth day, and estrone and 17 beta-e2 were measured at 12-day intervals from days 42-192. progeste ... | 1984 | 6541570 |
| effects of chronic d-leu6, des-gly10-gonadotropin releasing hormone ethylamide on male sex tissues. | the chronic administration of superactive agonists of gonadotropin releasing hormone (gnrh-a) have been reported to have a direct inhibitory effect on the sex tissues of the male rat. in an attempt to confirm or refute this statement, adult male rats were either left intact or were castrated and then treated daily for 14 days with either testosterone (t), dihydrotestosterone (dht) or sesame oil (vehicle). half of the intact and castrate animals also received daily injections of 200 ng of the gnr ... | 1984 | 6426536 |
| protein-rich food mixtures for feeding the young in egypt. 1. formulation. | ten protein-rich food mixtures were suggested. they are based on popular dishes which could be prepared simply at home. such mixtures were prepared from seeds or legumes available in the local markets at reasonable prices. these ingredients are polished rice, decorticated lentils, defatted sesame flour, whole or roasted chick peas (dehulled), maize bread, sun flour kernels, fenugreek seeds, wheat (whole grains or parboiled grains), white wheat flour, defatted peanut flour, defatted sesame flour ... | 1981 | 7340230 |
| combined cytotoxic and endocrine therapy for human breast carcinoma (br-10) serially transplanted into nude mice. | cytotoxic and endocrine therapy on a human breast carcinoma (br-10) serially transplanted into nude mice was given with reference to the sequence of drug administration. mitomycin c (mmc) was combined with 2.5 mg/kg of tamoxifen (tam). mmc was dissolved in 0.2 ml of physiological saline and administered intraperitoneally once weekly. tam was dissolved in 0.1 ml of sesame oil and administered intramuscularly twice weekly. both drugs were administered in the reverse sequence for 2 or 3 weeks. cyto ... | 1984 | 6429399 |
| effect of treatment with different doses of bromocriptine on plasma profiles of prolactin, gonadotrophins and testosterone in mature male rats and mice. | the influence of different doses of bromocriptine (cb-154) on plasma levels of prolactin (prl), fsh, lh and testosterone (t) in mature male rats and mice was studied. daily subcutaneous administration of 360 micrograms of cb-154 in sesame oil was sufficient to induce maximal suppression of plasma prl levels in mature male rats whilst subcutaneous implantation of two pellets of cb-154 and cholesterol, each containing approximately 6 mg cb-154, was effective in suppressing serum prl levels in matu ... | 1984 | 6434437 |
| prenatal and postnatal development of rats following the maternal treatment with testosterone during the late period of embryogenesis. | sprague-dawley derived female albino rats were administered subcutaneously 0.5, 1.5, or 3.0 mg/kg of testosterone acetate in sesame oil at single daily doses, from day 13 until day 16 of pregnancy (day 0 = spermatozoa). the pregnant females were either killed shortly before term or allowed to litter and raise their offspring. increased rates of prenatal death were observed in the three experimental groups of both these experiments. reduced body weight of foetuses and, respectively, young rats af ... | 1984 | 6541913 |
| [obtaining protein fractions from commercial sesame cakes (sesamum indicum)]. | sesame press cake represents an important potential protein source for human consumption. some of the limiting factors are its high crude fiber content, oxalic acid content, and its bitter taste. by fractionation of solvent-extracted sesame meal, several preparations were obtained which were analyzed for their nutrient content, protein utilization and digestibility. per values were low, and supplementation with lysine, skim-milk powder, soymeal or fish meal, improved the per values considerably. ... | 1984 | 6544057 |
| effects of combination estrogen:cyclophosphamide treatment on the growth of the mxt transplantable mammary tumor in the mouse. | the present studies were done to determine if the growth-promoting properties of estrogen on the mxt transplantable mammary tumor in the mouse would enhance the cytotoxicity of cyclophosphamide. mice bearing these tumors had beeswax pellets implanted which contained 17 beta-estradiol (0.01 to 1.0 mg/pellet) and/or injected twice weekly with cyclophosphamide (10 to 40 mg/kg body weight in sesame oil) for 4 to 7 weeks. during this time, tumor size [(l + w)/2] and body weights were monitored every ... | 1983 | 6850631 |
| behavioral characteristics of beef steers administered estradiol, testosterone and dihydrotestosterone. | twelve beef steers ranging in age from 6 to 8 mo were randomly assigned to one of four steroid treatment groups so the ability of each hormone to stimulate sexual and(or) agonistic behavior could be assessed. the steers received im injections of either 200 mg of testosterone (t), 200 micrograms of estradiol-17 beta (e2), 200 mg of dihydrotestosterone (dht) or sesame oil vehicle as control (c), every other day for 10 d. during these 10 d, behavior was studied for 60 min at 0600, 1200, 1800 and 24 ... | 1982 | 6891699 |
| systemic activity of nifluridide against sucking lice and the common scabies mite on cattle. | psoroptes ovis [hering] mites and sucking lice (linognathus vituli linnaeus) were eliminated from light to heavily infested calves with a single subcutaneous injection of nifluridide in five separate experiments. the compound was incorporated in a copolymer vehicle in a sesame oil suspension. in the first two experiments, mites were eliminated within 10 days following a 20 mg kg-1 injection. eight out of 9 calves were cleared of mites within 7 days post injection of nifluridide at 4, 6 and 9 mg ... | 1982 | 6891855 |
| lipotropic effect of estradiol-17 beta in fed and fasted lactating cows. | the lipotropic effect of estradiol-17 beta was measured in seven nonpregnant holstein-friesian cows 2 to 5 wk into lactation. the experiment was divided into an initial 3-day control period, 19 days treatment, and 2 days fast. jugular blood samples were taken twice daily during the control period, the last 2 days of treatment, and the fast. after the control period, four cows received daily injections of estradiol-17 beta benzoate (15 mg) in sesame oil for the remainder of the experiment whereas ... | 1982 | 7050192 |
| inhibitors of animal cell-free protein synthesis from grains. | we described earlier the purification and properties of a protein (tritin) from wheat that enzymatically inhibits translation in cell-free systems from animals but not plants. in this report, we have examined 11 additional grains (family gramineae) and three other seeds for the presence of tritin-like proteins. in addition to wheat species, barley, oats, rye, triticale and corn were found to be sources of inhibitor; no inhibitor could be detected in rice, millet, sesame, alfalfa, mung bean or co ... | 1982 | 7066324 |
| effects of testosterone propionate on hindlimb-immobilized rats. | forty albino male rats were randomly divided into 4 groups of 10. group i served as the nonimmobilized control and received daily placebo injections of sesame oil. the rats in group ii were castrated, their hindlimbs were immobilized using a plaster cast, and they received daily injections of sesame oil. the group iii rats were also castrated and casted but received a daily injection of 5 mg testosterone propionate. the animals in group iv were not castrated but were casted and received daily te ... | 1982 | 7107474 |
| comparison of the antispermatogenic effects of a new d-homo-steroid and testosterone in rabbits. | in comparison to testosterone, 18 beta-hydroxy-18 alpha-methyl-16 alpha-methylene-d-homo-5 alpha-androstane-3-one (d-homo-s) shows more pronounced anti-gonadotrophic than androgenic properties in rats. the present study was initiated in rabbits to investigate the potential of d-homo-s to suppress spermatogenesis. d-homo-s in sesame oil was administered at the doses of 0.1 (di), 3 (d ii) or 10 mg (d iii) per rabbit each day for 8 weeks. during treatment serum testosterone, sperm concentration and ... | 1982 | 7141725 |
| absence of a diurnal rhythm in lordosis behaviour induced by oestrogen in gonadectomized rats. | gonadectomized rats bearing s.c. silastic capsules containing crystalline oestradiol-17 beta diluted with cholesterol, or oestradiol-17 beta dissolved in sesame oil were tested for the presence of a diurnal rhythm in the display of lordotic behaviour. in experiment 1, female rats received four consecutive tests at intervals of 8 h in a lighting regimen of 12 h light: 12 h darkness beginning 4, 14 and 28 days after implantation of 5 mm capsules of oestradiol. after a single test on day 4, male ra ... | 1980 | 7191876 |
| hypophysectomy induced hypersensitivity to dopamine: antagonism by estrogen. | hypophysectomized (hypox) or sham hypox (sham) and ovariectomized rats were injected with either estradiol benzoate (eb, 10 microgram/kg/day x 3) or sesame oil (0.25 ml/kg/day x 3). twenty hours after the last dose of eb or oil all animals were injected with apomorphine and the resulting stereotypy scored. the hypox + oil group was more sensitive to the apomorphine than the sham + oil group (ed50 = 0.24 and 0.45 mg/kg, respectively). treatment with eb resulted in a shift to the right of the dose ... | 1981 | 7197571 |
| metabolic response to starvation. i. relative effects of pregnancy and sex steroid administration in the rat. | increased sensitivity to a fast with rapid onset of ketosis, hypoalaninemia, and hypoglycemia is characteristic of rat and human gestation. the present study examines the role of sex steroids in the development of these metabolic changes. subgroups of female rate received 10 microgram of estradiol (e), 10 mg of progesterone (p), or the two in combination (e + p) s.c. daily for 5 days. control rats (c) received sesame oil alone. different groups were starved 12, 24 and 48 hr during days 4 and 5 o ... | 1981 | 7207200 |
| the effects of 17 beta-estradiol and progesterone on the metabolism of free fatty acid by perfused livers from normal female and ovariectomized rats. | to determine whether any interaction occurs between progesterone and 17 beta-estradiol in the regulation of ffa metabolism by the liver, normal female rats were injected sc daily for 14 days with 7.5, 15, 50, or 100 microgram 17 beta-estradiol/kg, 25 mg progesterone/kg, 15 microgram 17 beta-estradiol plus 25 mg progesterone/kg, or vehicle (sesame oil) alone. to determine the effects of these hormones in the absence of endogenous estradiol and progesterone, ovariectomized rats were treated with t ... | 1981 | 7215287 |
| potential mold growth, aflatoxin production, and antimycotic activity of selected natural spices and herbs. | ground spices and herbs are evaluated as substrates for mycelial growth, sporulation, and aflatoxin production. three toxigenic strains of aspergilli, a. flavus atcc 15548, a. flavus nrrl 3251, and a. parasiticus nrrl 2999, were cultured on moist, commercially packaged herbs and spices. all substrates used were ground and included thyme, celery seed, oregano, cinnamon, ginger, caraway seed, clove, mustard, sesame seed, and rosemary leaves. following inoculation of the natural materials in steril ... | 1981 | 7275911 |
| effect of chronic treatment of spontaneously hypertensive rats with d 600. | the effects of chronic treatment of spontaneously hypertensive rats (shr) with methoxyverapamil (d 600) on blood pressure (bp) and on the in vitro contractile response of aortic and portal vein strips of rats were examined. d 600, prepared as the free base and dissolved in sesame oil, was injected subcutaneously daily into shr to maintain the systolic blood pressure (sbp) at less than 130 mm hg for 24 hours after injections. the dose required increased progressively from 4 to 8.5 mg/day/rat. as ... | 1981 | 7298120 |
| morphological effects of diethylstilbestrol on neonatal mouse uterus and vagina. | administration of diethylstilbestrol (des) to neonatal mice causes a high incidence of vaginal adenosis comparable to adenosis in women who were exposed to des in utero. in the present study, scanning electron microscopy was used to investigate morphological events that might be involved in the development of adenosis. the effects of des on luminal epithelia of neonatal mouse uterus, vaginal canal, and vaginal fornix were compared with the effects of the drug on those tissues of the adult mouse. ... | 1981 | 7306983 |
| hyperprolactinemia and hyperadrenocorticism accompanied by normal blood pressure in sprague-dawley rats. | pituitary glands removed from adult female normotensive sprague-dawley (s-d) rats were implanted beneath the renal capsule of 100-day male s-d rats. female neonatal s-d rats were given a single sc injection of 1.25 mg of testosterone proprionate (tp) suspended in sesame oil. systolic blood pressure and blood samples were taken at various time intervals postimplantation and tp treatment prio to autopsy. both the tp treatment and pituitary implants caused hyperprolactinemia, increased adrenal weig ... | 1981 | 7323061 |
| induced corpora lutea in the postpartum beef cow. ii. effects of treatment with progestogen and gonadotropins. | seventy-three multiparous beef cows (21 to 35 d postpartum) were used in an experiment with a 2 x 4 factorial design to test the effects of pretreatment with norgestomet and preovulatory gonadotropic stimulation on the life span of corpora lutea induced by human chorionic gonadotropin (hcg). cows were implanted subcutaneously for 9 d with norgestomet (3 mg; 35 cows) or sham-implanted (38 cows). hcg (1,000 iu) was administered in to all cows 36 h (time = 0) after implant removal. each cow receive ... | 1982 | 6806234 |
| alterations of plasma hdl lipids and apolipoproteins in female rats treated with ethynyl estradiol. | female sprague-dawley rats (160-200 g body weight) were injected subcutaneously daily for 14 days with 1, 5, 15, 50 or 100 micrograms ethynyl estradiol in sesame oil/kg body weight, or with oil alone. food consumption was restricted to 15 g/day, and animals were fasted overnight before exsanguination. concentrations of plasma cholesteryl ester decreased with increasing dosage of ethynyl estradiol, as a result of decreases in hdl cholesteryl ester. concentrations of plasma unesterified cholestero ... | 1981 | 7326248 |
| effects of in-vivo administration of sex hormones on luteinizing hormone-stimulated steroid accumulation by isolated rabbit ovarian follicles. | the effects of in-vivo administration of progesterone, testosterone propionate (tp) and oestradiol benzoate (ob) on steroid accumulation by isolated rabbit ovarian follicles were examined. progesterone administration led to a suppression of follicular androgen accumulation when compared to controls injected with sesame oil. follicles from these rabbits, when stimulated with lh, produced significant amounts of androgens. administration of tp resulted in an increase in peripheral serum concentrati ... | 1981 | 7328373 |
| effect of age upon uterine response to deciduagenic stimulus. | the effect of aging upon ability of the uterus to respond to a deciduagenic stimulus was studied by transmission electron microscopy. particularly, subtle structural characteristics of decidualization were sought in stromal cells of uteri of aged rats. to negate effects of ovarian aging, rats, 4, 10 and 20-24 months of age were subjected to bilateral ovariectomy and subsequent ovarian hormone injections. as deciduagenic stimulus, sesame oil was injected into the right uterus. the left served as ... | 1981 | 7331748 |
| enhanced fecal elimination of stored hexachlorobenzene from rats and rhesus monkeys by hexadecane or mineral oil. | the effect of various dietary treatments on the fecal excretion of [14c]-hexachlorobenzene (hcb) was studied in rats and rhesus monkeys. cholestyramine and sesame oil failed to influence fecal excretion of hcb and/or metabolites. however, dietary administration of n-hexadecane (5%) increased fecal excretion of radioactivity 4-13-fold in rats and rhesus monkeys. similarly, mineral oil in the diet (5%) of rhesus monkeys elicited a 6-9-fold increase in fecal excretion of hcb and/or metabolites. as ... | 1981 | 7336436 |
| a simple non-radioactive method for the simultaneous quantitative determination of stomach empyting and intestinal propulsion in the intact conscious rat. | a simple non-radioactive method for the simultaneous assessment of stomach emptying and intestinal propulsion in intact fasted conscious rats was developed employing amberlite pellets. the amberlite pellets were administered by gastric gavage and the rats were killed 20 or 120 min later. the number and percent of the pellets in the stomach and intestines and the distance travelled by each pellet in the small intestine were determined. the distance travelled by the leading pellet in the small int ... | 1980 | 7353732 |
| [histological changes in the adrenal cortex of the syrian hamster following perinatal treatment with sex steroids]. | the adrenal cortex of the syrian golden hamster is influenced by androgen hormone, for during puberty sex dimorphism of the adrenal cortex can be observed; it is prevented by perinatal castration. the following study will show, if and how other steroids influence the adrenal cortex of the normal and castrated female and male golden hamster. beginning perinatally, groups of 10 hamsters each (intact and castrated males and females, altogether 160 animals) received testosterone hexohydrobenzoate (t ... | 1980 | 7406214 |
| progesterone, estradiol, testosterone and dihydrotestosterone: effects on rate of extinction of a conditioned taste aversion in rats. | an investigation was made to determine why the prolonged rate of extinction of a conditioned taste aversion induced by testosterone is diminished when the ovarian system is intact. in the first experiment, 36 gonadectomized female rats received injections of progesterone, testosterone propionate (tp), progesterone plus tp, or sesame oil. progesterone did not reduce the slow extinction rate induced by tp. in a second experiment, 36 gonadectomized female rats received injections of estradiol dipro ... | 1980 | 7413784 |
| topical retinoic acid in the treatment of experimental xerophthalmia in the rabbit. | the purpose of this study was to evaluate the efficacy of topical retinoic acid (tretinoin) in the treatment of various stages of xerophthalmia caused by vitamin a deficiency. at the beginning of treatment, rabbits with similar disease in both eyes were given a normal diet and therapeutic doses (25,000 iu) of systemic vitamin a. one eye of each was treated with 0.1% retinoic acid in sesame oil one time per day. the other eye received sesame oil alone. eyes with moderate disease (advanced keratin ... | 1981 | 7469870 |
| the rat model of tardive dyskinesia: relationship between vacuous chewing movements and gross motor activity during acute and long-term haloperidol treatment. | tardive dyskinesia (td) is a serious side-effect of neuroleptic treatment. in order to describe and analyse more thoroughly the rat model of td, the behavior of the rats during cage testing was studied after acute and during long-term haloperidol (hal) treatment. rats were injected with hal i.p. in an acute experiment, and in a long-term experiment, rats were treated for 4-12 months with hal decanoate im. control rats received saline or sesame oil. the behavior was videotaped one h after the i.p ... | 1995 | 7475980 |
| toxic effects of butylated triphenyl phosphate-based hydraulic fluid and tricresyl phosphate in female f344 rats. | triaryl phosphates, including tricresyl phosphate (tcp and butylated triphenyl phosphates (btp), are used in the commercial manufacture of plastics, lubricants, and hydraulic fluids. recent reports implicate these compounds as endocrine and reproductive toxicants that can cause cholesteryl lipidosis in adrenocortical (ac) and ovarian interstitial (oi) cells, suggesting altered metabolism of steroid hormones or cholesterol or of both. we investigated potential mechanisms of btp and tcp toxicity t ... | 1995 | 7483214 |
| down-regulation of the hypothalamo-pituitary-adrenal axis reduces brain damage and number of seizures following hypoxia/ischaemia in rats. | several reports suggest that the activity of the hypothalamo-pituitary-adrenal axis (hpa-axis) is increased following hypoxia/ischaemia and that this might be associated with increased neuronal vulnerability. the main goal of this study was to examine the effects of down-regulation of the hpa-axis on the hypoxia/ischaemia-induced (1) rise of plasma corticosterone levels, (2) seizures, and (3) brain damage. down-regulation of the hpa-axis was induced by prolonged corticosterone treatment lasting ... | 1995 | 7496805 |
| anti-androgen effects of the aromatase inhibitor, atamestane. | prostatic hyperplasia can be induced in both intact and castrated dogs and in intact cynomolgus monkeys by the administration of androgenic steroids. estrogenic steroids potentiate this effect in dogs. these changes also can be induced by androstenedione, which increases androgen and estrogen levels. atamestane (ata; 1-methyl-3,17-dione-androsta-1,4-diene), a potent aromatase inhibitor, inhibits some of the androstendione-induced effects; however, the nonsteroidal aromatase inhibitor, cgs-16949a ... | 1995 | 7559139 |
| antihypertensive effect of sesamin. i. protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy. | we investigated the antihypertensive effect of sesamin, a lignan from sesame oil, using deoxycorticosterone acetate (doca)-salt hypertensive rats. the animals were unilaterally nephrectomized, and then separated into a sham-operated group (sham group) and a doca-salt-treated group. the latter was further separated into a normal diet group (control group) and a sesamin-containing diet group (sesamin group). the systolic blood pressure of control group progressively increased in comparison with th ... | 1995 | 7581242 |
| xenoestrogens alter mammary gland differentiation and cell proliferation in the rat. | we investigated mammary gland differentiation and cell proliferation in rats after acute exposure to xenoestrogens. pubertal female sprague-dawley rats (six/group) were treated for 1 week with diethylstilbestrol (des), genistein, o,p'-ddt, aroclor 1221, aroclor 1254, 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd), or the vehicle, sesame oil. animals were killed 18 hr after the last treatment. analysis of mammary whole-mounts revealed that exposure to des, genistein, and o,p'-ddt resulted in enhanced ... | 1995 | 7588483 |
| studies on the establishment of appropriate spermatogenic endpoints for male fertility disturbance in rodent induced by drugs and chemicals. i. nitrobenzene. | the effect of nitrobenzene on several spermatogenic endpoints was examined to determine which endpoints were affected by chemicals, how changes in spermatogenic endpoints are related to decreases in the rate of male fertility, and how long a treatment period is needed before damage can be detected. an experimental group of male sprague-dawley rats was given nitrobenzene (60 mg/kg, per os), a known inhibitor of male fertility, and a control group was given a diet of sesame oil (1 ml/kg, per os) a ... | 1995 | 7595970 |
| role of chloride groups in the nephrotoxic potential of n-(3,5-dichlorophenyl)-2-hydroxysuccinimide, an oxidative metabolite of n-(3,5-dichlorophenyl)succinimide. | although the addition of chloride groups to the phenyl ring of n-phenylsuccinimide (nps) is known to enhance the nephrotoxic potential of nps, the mechanism of this enhancement is unknown. one chlorinated nps derivative, n-(3,5-dichlorophenyl)succinimide (ndps), is a potent nephrotoxicant which induces marked proximal tubular necrosis at i.p. doses of 0.4 mmol/kg or greater. the purpose of this study was to compare the nephrotoxic potential of 2-hydroxy-n-phenylsuccinimide (hnps) and n-(3,5-dich ... | 1995 | 7604399 |
| perioperative intratumoral administration of cisplatin for treatment of cutaneous tumors in equidae. | twenty-seven horses (and 1 mule) with 32 histologically confirmed cutaneous tumors were studied to evaluate the effects of intratumoral injection of cisplatin initiated at the time of surgery. as a result of surgery, 9 of the wounds were closed primarily (5 sarcoids, 4 carcinomas) and 23 were left open to granulate (16 sarcoids, 6 carcinomas, 1 hamartoma). chemotherapy consisted of 4 treatment sessions of intratumoral injection of cisplatin in purified sesame oil at 2-week intervals. the first t ... | 1994 | 7890578 |
| role of progesterone in regulating the effect of estradiol on the secretion of thyrotropin-releasing hormone and dopamine into hypophysial portal blood in ovariectomized rats. | in this study, an investigation was undertaken regarding the effects of estradiol and progesterone on the secretion of thyrotropin-releasing hormone (trh) and dopamine into hypophysial portal blood and on the concentrations of arterial plasma thyroid-stimulating hormone (tsh) and prolactin (prl) in ovariectomized (ovx) rats. ovx rats were injected subcutaneously with either estradiol benzoate (25 micrograms/kg bw/day) or progesterone (10 or 50 mg/kg bw/day), or both estradiol benzoate and proges ... | 1995 | 7617131 |
| effect of dimethyl sulfoxide on n-(3,5-dichlorophenyl)succinimide (ndps) and ndps metabolite nephrotoxicity. | dimethyl sulfoxide (dmso) is frequently used as a solvent to assist in dissolving compounds which are not readily soluble in other injection vehicles. the purpose of this study was to determine the suitability of dmso as a vehicle for administering the nephrotoxicant, n-(3,5-dichlorophenyl)succinimide, (ndps) and two nephrotoxicant ndps metabolites, n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs) and n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (ndhsa). male fischer 344 rats (4/group) were ... | 1995 | 7624885 |
| trial of a new medium-term model using benzo(a)pyrene induced lung tumor in newborn mice. | a new medium-term in vivo model was tried using pulmonary adenoma induced by benzo(a)pyrene (bp) in newborn mice. both inbred mice such as c57bl/5j, c57br/cdj. a/j mice and non inbred n:gp(s) mice were used. benzo(a)pyrene was injected in the subscapular region of newborn mice within 24 hours after birth at a dose of 0.5 mg and 1 mg per mouse, respectively. after 9 weeks lung tumor induced in n:gp(s) and a/j mice but in the other mice. the dose showing a 50% tumor incidence was found in n:gp(s) ... | 1995 | 7645968 |
| increased lipopolysaccharide-induced tumour necrosis factor levels and death in hypercholesterolaemic rabbits. | nutritional-induced hypercholesterolaemia in new zealand rabbits causes increased susceptibility to experimental infections. rabbits fed cholesterol (0.5 g%) for 8 weeks were injected intravenously with varying doses of escherichia coli 0127: b8 lipopolysaccharide (lps; 3-100 micrograms/kg). the levels of cholesterol, triglycerides, tumour necrosis factor (tnf), and the survival rates of treated rabbits were then measured. rabbits fed either normal chow or chow impregnated with sesame oil were u ... | 1995 | 7648721 |
| sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. | six groups of rats were fed diets low, but adequate, in alpha-tocopherol but high in gamma-tocopherol. the six diets differed only in their contents (0, 0.25, 0.5, 1.0, 2.0, and 4.0 g/kg, respectively) of sesamin, a lignan from sesame oil. after four weeks of ad libitum feeding, the rats were sacrificed and the concentrations of alpha- and gamma-tocopherols were measured in the plasma, livers, and lungs. sesamin-feeding increased gamma-tocopherol and gamma-/alpha-tocopherol ratios in the plasma ... | 1995 | 7651076 |
| androgenic-anabolic steroids modify beta-endorphin immunoreactivity in the rat brain. | immunocytochemical localization of beta-endorphin in the brains of intact and castrated male rats was conducted after the administration of high levels of androgenic-anabolic steroids (aas; 14 daily injections of sesame oil or a cocktail of 2 mg/kg testosterone cypionate, 2 mg/kg nandrolone decanoate, and 1 mg/kg boldenone undecylenate) at doses commonly self-administered by athletes who are considered 'heavy abusers'. in normal intact oil-treated males, cytoplasmic immunoreactivity was prevalen ... | 1995 | 7712181 |
| effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo. | the effects of testosterone (t) on uptake and mobilization of orally administered triglyceride were examined in male rats. in order to attempt to explain regional differences, adipose tissue metabolism was studied in vivo. (u-14 c) oleic acid in sesame oil was given by gastric gavage to male, sham operated, castrated and castrated + t substituted rats, and accumulation and half-life of radioactivity measured. in castrated rats in comparisons with sham-operated and castrated + t rats, serum t was ... | 1995 | 7719957 |
| effects of estrogen and estrogen receptor messenger rna levels in young and middle-aged female rats: comparison of medial preoptic area and mediobasal hypothalamus. | we examined the effects of estrogen on estrogen receptor (er) mrna in the rat hypothalamus during aging. two-month-old (young) and 9-month-old (middle-aged) rats were ovariectomized (ovx) and after 10 days given an injection of estradiol benzoate (20 micrograms/rat). the young rats were sacrificed 4 h, 24 h and 72 h, and the middle-aged rats 72 h after estrogen injection. control rats received a sesame oil injection. the medial preoptic area (mpo) and mediobasal hypothalamus (mbh) were dissected ... | 1994 | 7725819 |
| dietary fish oil affects food intake, growth and hematologic values of weanling rats. | the object of this study was to evaluate the effect of increasing amounts of dietary fish oil on growth and hematological variables of the weanling male sprague-dawley rat. animals were fed diets containing either fish oil (fo) or sesame oil (so) at 5, 10 or 15% (w/w) for 31 d. growth retardation and reduced food intake was noted in groups fed fo. hemoglobin (hb) concentration diminished when the dietary fo was above 5% (w/w). fo is a poor source of (n-6) fatty acids. we postulate that a partial ... | 1994 | 7733799 |
| pharmacokinetics of the acyl coenzyme a:cholesterol acyl transferase inhibitor cp-105,191 in dogs--the effect of food and sesame oil on systemic exposure following oral dosing. | inhibition of acyl coenzyme a:cholesterol acyl transferase (acat) decreases total plasma cholesterol in animals and may be an effective therapy for atherosclerosis in man. the pharmacokinetics of cp-105,191, a potent inhibitor of acat, were explored in fed and fasted dogs. following oral administration of drug, mean apparent plasma half-life ranged from 9 to 16 h. systemic availability of cp-105,191, as determined by auc(0-infinity), was approximately 3-4-fold higher in fed dogs than in fasted d ... | 1995 | 7738788 |
| androgenic, not estrogenic, steroids alter neuromuscular synapse elimination in the rat levator ani. | developmental synapse elimination in the rat levator ani (la) muscle is sensitive to gonadal androgen. this process occurs faster in castrated male rats that lack gonadal testosterone and is largely prevented by testosterone treatment. because testosterone can be irreversibly converted into either androgenic metabolites such as dihydrotestosterone or estrogenic metabolites such as estradiol, the present experiment sought to determine which of these metabolites account for testosterone's effect. ... | 1995 | 7743641 |
| effects of adrenalectomy on reproduction in the mouse. | survival of mice treated with sesame seed oil after adrenalectomy was very low and suggested no beneficial effect, whereas treatment with progesterone improved the chances of survival. treatment with desoxycorticosterone acetate (doca) and methyl prednisolone acetate also increased the number of animals surviving after adrenalectomy. the corticosteroids were significantly more effective in ensuring survival than was progesterone. there was no significant difference in survival between mice recei ... | 1980 | 7430885 |
| anaphylaxis after sesame seed ingestion. | four patients with histories of systemic anaphylaxis or angioedema and urticaria after ingestion of sesame seed or sesame oil-containing products were studied for anti-sesame seed extract ige by the radioallergosorbent test (rast). three of four were found to be positive. rast inhibition after density-gradient ultracentrifugation of sesame seed extract indicates that the most active allergens appear to have molecular weights between 8,000 to 62,000 daltons. | 1981 | 7451770 |
| a slow release formulation for recombinant bovine interferon alpha i-1. | recombinant bovine interferon-alpha i1 (rboifn-alpha) has known antiviral and immunomodulatory effects which have been exploited to reduce clinical disease in a number of clinical situations including bovine respiratory diseases. a slow release rboifn-alpha formulation may be of value to reduce bovine respiratory disease under field conditions by extending the period of protection, and hence improving the prophylactic benefits of rboifn-alpha. in this report, we describe a formulation of rboifn- ... | 1994 | 8141591 |
| oestrogen but not testosterone increases bone density in orchiectomized rats more when fed moderately magnesium-deficient fructose than moderately magnesium-deficient cornstarch. | to investigate interactions between circulating sex hormones, dietary fructose and magnesium on bone mineral density and numbers of trabeculae, 10 weeks old orchiectomized and sham-orchiectomized rats were studied. one-third of the orchiectomized animals were injected with beta-oestradiol-3-benzoate twice per week in sesame oil; another one-third, testosterone cypionate; the remaining one-third as well as the sham-orchiectomized animals, sesame oil only. all animals were fed either fructose or c ... | 1994 | 7786685 |
| in vivo effect of vitamin e on serum and tissue glycoprotein levels in perchloroethylene induced cytotoxicity. | the antioxidant efficacy of vitamin e on perchloroethylene (per) induced cytotoxicity has been studied in rats. feeding per to rats for 42 days using sesame oil as vehicle alters total protein and protein bound carbohydrate components in liver and kidney of experimental animals. supplementation of vitamin e prevented the changes observed in total protein and protein bound carbohydrate components of per administered rats. histopathological studies also show the effectiveness of vitamin e on per a ... | 1995 | 7791740 |
| effect of substituting sesame meal for soybean meal on layer and broiler performance. | sesame meal (sm, 47.1% cp) has an amino acid composition similar to that of soybean meal (sbm, 47.7% cp) with the exception of lower lysine and higher methionine, but has been relatively underutilized in poultry feeds. two experiments (1 and 2) were conducted to measure laying performance and hatchability of white leghorn hens fed practical diets (17% cp), and two additional experiments (3 and 4) examined the performance of broiler chicks fed practical diets (22% cp) with varying substitution le ... | 1995 | 7792239 |
| dietary factors and stomach cancer: a case-control study in korea. | stomach cancer is the most common cancer among koreans. there is wide agreement that dietary factors are important in gastric carcinogenesis, but the role of many korean food items remains unknown. | 1995 | 7797354 |
| pathologic effects of butylated triphenyl phosphate-based hydraulic fluid and tricresyl phosphate on the adrenal gland, ovary, and testis in the fischer-344 rat. | triaryl phosphates including tricresyl phosphate (tcp) and butylated triphenyl phosphates (btps) are used in the commercial manufacture of plastics, lubricants, and hydraulic fluids. recent reports implicate these compounds as endocrine and reproductive toxicants in rodents. the objectives of this study were to develop and characterize a rat model to investigate the mechanism(s) of toxicity of triaryl phosphate-based hydraulic fluids and to elucidate potential mechanistic pathways of toxicity th ... | 1994 | 7817124 |
| uterine vascular permeability after uterine stimulation to rats differentially sensitized for the decidual cell reaction. | uterine vascular permeability (vp) was assessed after unilateral intrauterine injection of sesame oil to rats given either optimal sensitization for the decidual cell reaction or one of several forms of suboptimal sensitization. the study was intended to determine the relationship between changes in uterine vp and imminent endometrial decidualization. uterine vp was estimated by the rate at which the uterine volume of distribution of i.v. injected 125i-labeled albumin approached the uterine extr ... | 1994 | 7828078 |
| [protective effects of sesamol and its related compounds on carbon tetrachloride induced liver injury in rats]. | sesamol is a kind of antioxidant and exists in sesame oil. this paper describes the protective effect of sesamol against carbon tetrachloride (ccl4)-induced liver injury in rats. sesamol had a significant effect in case of intraperitoneal, subcutaneous and oral administration. in order to examine the relationship between the chemical constitution of sesamol and its protective effect, the protective effects of 20 kinds of sesamol related compounds against liver injury induced by ccl4 were investi ... | 1994 | 7853152 |
| effect of chemical form, route of administration and vehicle on 3,5-dichloroaniline-induced nephrotoxicity in the fischer 344 rat. | chloroanilines are widely used chemical intermediates for the manufacture of dyes, agricultural chemicals and industrial compounds. nephrotoxicity occurs as one toxicity following intraperitoneal (i.p.) administration of chloroaniline hydrochlorides to rats. the purpose of this study was to examine the effect of chemical form, route of administration and vehicle on 3,5-dichloroaniline-induced nephrotoxicity. in one set of studies, male fischer 344 rats (four to eight per group) were administered ... | 1994 | 7884146 |
| antioxidative effects of a processed grain food. | antioxidant biofactor: aob is a unique processed grain food. it is a yellow-green powder. it contains the following extracts: germ extracts, soybean, rice bran, tear grass, sesame, wheat, citron, green tea, green leaf extract, and malted rice. these materials were slowly roasted under a powdered oure at less than 60 degrees c and fermented with aspergillus oryzae over 3 days to transform each ingredient into low molecular weight substances. these conditions were different by each material, envir ... | 1994 | 7891207 |
| effects of nicotine and tobacco-specific nitrosamines on hamster cheek pouch and gastric mucosa. | fifty-two hamsters were divided into 6 groups and their cheek pouches treated with either 0.01% nnn, 0.01% nnn and 6% nicotine, 0.01% nnk, 0.01% nnk and 6% nicotine, 6% nicotine, or sesame oil. after painting each pouch 3 times per week for 13 months, the animals were killed and specimens from the cheek pouch and forestomach examined. cheek pouch epithelium showed more frequent histologic changes, including hyperplasia, hyperkeratosis and, in one animal, moderate dysplasia, when nicotine was com ... | 1994 | 7932244 |
| fatal neurotoxicity of arteether and artemether. | artemisinin (qinghaosu) and several derivatives have been developed and are in use as antimalarial drugs but scant information is available regarding animal or human toxicity. following a eight-day, multiple-dose, pharmacokinetic study of arteether (ae) (10 mg/kg/day [n = 6] and 20 mg/kg/day [n = 6]) in dogs, all high-dose animals displayed a progressive syndrome of clinical neurologic defects with progressive cardiorespiratory collapse and death in five of six animals. neurologic findings inclu ... | 1994 | 7943542 |
| regulation of steroid 21-hydroxylation by 17 beta-estradiol in rat liver: in vivo and in vitro study. | in various extraadrenal organs, progesterone (p4) is converted to deoxycorticosterone (doc) by steroid 21-hydroxylation. to investigate the regulation of extraadrenal 21-hydroxylase activity by 17 beta-estradiol (e2), the following two experiments were performed. exp. 1). three-week-old male sd rats were testectomized (tx) and injected with e2 (1 mg) or sesame-oil s.c. sham rats were treated with sesame-oil. in these groups the serum concentration of doc and corticosterone (b), microsomal 21-hyd ... | 1993 | 7951505 |
| neuromodulation of transplanted gonadotropin-releasing hormone neurons in male and female hypogonadal mice with preoptic area brain grafts. | implantation of normal preoptic area (poa) tissue into the third ventricle of adult hypogonadal (hpg) mice provides a source of gnrh neurons that innervate the host median eminence and stimulate reproductive development in the sterile mutants. to further evaluate graft-host integration, the effects of n-methyl-d,l-aspartic acid (nma) and opiate antagonists on lh secretion in hpg mice with poa transplants (hpg/poa) were tested. nma challenges significantly stimulated lh secretion in 10 of 11 hpg/ ... | 1995 | 7756451 |
| safety and efficacy of intraperitoneal injection of etoposide in oil suspension in mice with peritoneal carcinomatosis. | we compared the safety and efficacy in mice with peritoneal carcinomatosis of two etoposide formulations: an aqueous solution (etp-sol) and particles suspended in oil (the addition products of iodine and the ethyl esters of the fatty acids obtained from poppy-seed oil (lipiodol) or sesame oil; etp-oil). we also investigated tissue distribution of etoposide in rats treated with etp-oil and etp-sol. etoposide was injected intraperitoneally at concentrations ranging from 52 to 392 mg/kg (increasing ... | 1995 | 7781140 |
| treadmill exercise training and estradiol differentially modulate hypothalamic-pituitary-adrenal cortical responses to acute running and immobilization. | it is generally believed that physical fitness promotes health by attenuating responsiveness to other stressors. the experimental evidence for this belief is limited and does not extend to interactions between the hypothalamic-pituitary-adrenal cortical (hpa) and hypothalamic-pituitary-gonadal (hpg) axes. we tested the hypothesis that treadmill exercise training would lead to an estrogen-dependent hyporesponsiveness of the hpa axis that would generalize to immobilization stress. ovariectomized f ... | 1995 | 7786348 |
| urinary enzyme excretion as a parameter for detection of acute renal damage mediated by n-(3,5-dichlorophenyl)succinimide (ndps) in fischer 344 rats. | the kidney has been identified as the specific target organ for in vivo exposure to an agricultural fungicide, n-(3,5-dichlorophenyl)succinimide (ndps). the goal of this study was to determine if urinary protein and enzyme excretion were sensitive, non-invasive markers for ndps-induced renal damage. the proximal tubular enzymes that were monitored were the brush-border enzyme alkaline phosphatase (alp) and the lysosomal enzyme n-acetyl-beta-d-glucosaminidase (nag). male fischer 344 (f344) rats w ... | 1994 | 7963241 |
| a comparison of the effects of repeated stressor exposures and corticosterone injections on plasma cholesterol, thyroid hormones and corticosterone levels in rats. | persistently elevated serum cholesterol (chol) levels have been observed in rats given repeated stressor exposures and fed a normal laboratory diet. to determine the relative contribution of persistent hormone changes in the hypothalamic-pituitary-adrenal (hpaa) and thyroid axes to persistent stress-induced chol elevations, the present experiment assessed the contribution of persistently elevated corticosterone (cort) from both endogenous and exogenous sources. groups of rats were exposed for 7 ... | 1994 | 7968235 |
| reproductive toxicity of butylated triphenyl phosphate and tricresyl phosphate fluids in f344 rats. | the effects of tricresyl phosphate (tcp) and butylated triphenyl phosphate (btp)-based hydraulic fluid on reproduction were studied in f344 rats using a modification of the national toxicology program's continuous breeding protocol. groups of breeding pairs received single daily oral doses of an equal volume of either 0, 0.6, 1.0 g btp/kg or 0.4 tcp/kg in sesame oil or 1.7 g neat btp/kg for up to 135 days. a naive control group allowed to breed, but not dosed or handled daily, demonstrated that ... | 1994 | 8050634 |
| effect of chronic haloperidol treatment on dopamine-induced inositol phosphate formation in rat brain slices. | the effects of chronic haloperidol administration on the accumulation of inositol phosphates were examined in rat brain slices pre-labeled with [3h]myo-inositol and incubated with various dopaminergic drugs. rats were treated with haloperidol-decanoate or its vehicle (sesame oil) for two, four or six weeks. dopamine and the selective d1 agonist, skf38393, induced a significant increase in lithium-dependent accumulation of [3h]inositol monophosphate (ip1) in the frontal cortex, hippocampus and st ... | 1994 | 8065524 |
| [occupational asthma caused by organic substances]. | occupational asthma (oa) to organic substances is frequently related to ige-dependent hypersensitivity. new etiological agents are latex and vegetal gums, in health care personnel as in carpet-making manufactures. bakers are exposed to numerous allergens: wheat and cereal flours, sesame and other seed proteins, alpha-amylase and other enzymes. alpha-amylase extracted from aspergillus orizae is a potent allergen. plant derived materials have been identified as allergens in the floral industry (fi ... | 1994 | 8079074 |
| cessation of the electrical activity of gonadotropin-releasing hormone pulse generator during the steroid-induced surge of luteinizing hormone in the rat. | neuronal activity in the mediobasal hypothalamus was recorded during the steroid-induced surge of luteinizing hormone (lh) in ovariectomized female rats by means of multiunit activity (mua) recording techniques. the day of subcutaneous implantation of estradiol-containing silastic tubing, which was done at 12.00 h, was designated as day 1, and progesterone (1 mg) dissolved in sesame oil was injected at 12.00 h on day 5. the hypothalamic mua and serum lh level were monitored between 10.00 and 20. ... | 1994 | 8084374 |
| mammary gland morphology and responsiveness to regulatory molecules following prenatal exposure to diethylstilbestrol. | female aci rats were exposed to diethylstilbestrol (des) in utero to evaluate the effects on the peri-pubertal mammary gland with respect to 1) mammary gland morphology, 2) sensitivity to natural and synthetic estrogens, and 3) sensitivity to endogenous epidermal growth factor (egf). pregnant rats were injected with vehicle (sesame oil) or des (total dose, 8.0 micrograms) on days 15 and 18 of gestation. des-exposed and control offspring were ovariectomized at 34 days of age and sacrificed at day ... | 1993 | 8102210 |
| progesterone and estradiol interaction in the regulation of rat uterine weight and estrogen receptor concentration. | autologous down-regulation of hormone receptors has been shown for several steroid hormones. we have previously shown estradiol (e2) regulates estrogen receptor (er) in ovariectomized (ovx) rats. these studies have been extended to investigate the interaction between progesterone (p) and e2 in the regulation of er and uterine weight. we implanted silastic capsules containing varying concentrations of e2 (0.0005 mg e2/ml to 5.0 mg e2/ml of sesame oil) into adult female sprague-dawley rats one wee ... | 1994 | 8108464 |
| early exposure to low levels of estradiol (e2) mitigates e2-induced conditioned taste aversions in prepubertally ovariectomized female rats. | 17 beta-estradiol (e2) can serve as a potent unconditioned stimulus in producing a conditioned taste aversion to saccharin in rats, with the effect being greater in males than in females. to determine whether the female's lower susceptibility to such conditioning is due, in part, to early experience with estrogen, we performed the following experiment. first, we pretreated groups of prepubertally ovariectomized female rats with either sesame oil (control group) or low doses of e2 (0.3, 0.75, or ... | 1994 | 8140166 |
| developmental changes in the gonadotropin releasing hormone neuron of the female rabbit: effects of tamoxifen citrate and pregnant mare serum gonadotropin. | developmental changes in immunostained gonadotropin releasing hormone neurons were demonstrated in female rabbits assigned to the following treatment groups: (i) tamoxifen citrate, 10 mg.kg-1 x day-1, in sesame seed oil (vehicle) (n = 24) or (ii) vehicle alone (control, n = 24) for 108 days; and (iii) 50 iu of pregnant mare serum gonadotropin on postnatal days 22 and 25 (n = 24) or vehicle on nontreatment days. treatments had no effect on the total number of immunostained cells, but there was a ... | 1993 | 8143234 |