Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| further studies in experimental atherosclerosis. | cholesterol dissolved in sesame oil and injected regularly for a period of from 7 to 8 months into the jugular vein of four young dogs has caused in each animal larger and smaller nodules protruding to some degree into the lumen of the pulmonary artery and also here and there some diffuse thickenings, the whole closely resembling human arteriosclerosis. these changes commence at the origin of the pulmonary artery immediately behind the semilunar valves. they seem a little more pronounced in thos ... | 1917 | 19868168 |
| adjuvants in immunization with influenza virus vaccines. | subcutaneous inoculation, of pr8 allantoic fluid, or watery suspensions of the virus obtained from allantoic fluid by high-speed centrifugation or by elution after adsorption on red cells induced serum antibodies in experimental animals, which reached the highest levels within 2 weeks after inoculation and were gradually lost thereafter. the addition of killed acid-fast bacteria (myco. tuberculosis or butyricum), paraffin oil, and a proprietary adsorption base (falba) to form a stable water-in-o ... | 1944 | 19871431 |
| kidney damage in the golden hamster following chronic administration of diethylstilbestrol and sesame oil. | 1947 | 20270734 | |
| value of corozo palm nut and sesame oil meals, bananas, a.p.f. and cow manure in rations for growing and fattening pigs. | 1951 | 14832163 | |
| studies on mold lipase; comparative study of lipases obtained from molds grown on sesamum indicum. | 1952 | 14953422 | |
| the effect of hypophysectomy on 9,10-dimethyl-1,2-benzanthracene-induced carcinogenesis [abstract]. | in view of the findings of moon, simpson, and evans (science, 116:331,1952) that the hypophysectomized rat was refractory to the carcinogenic effect of methyl-cholanthrene, similar experiments have been conducted but using the more powerful carcinogen 9,10-dimethyl-1,2-benzanthracene. the results of 2 separate experiments were as follows: all animals received 5 mg in sesame oil of the carcinogen intramuscularly. in the control animals, 15 showed discrete sarcoma out of 21 animals in 4-5 month ... | 1954 | 12338146 |
| effects of testosterone, sesame oil, and castration on tissue respiration of male rats exposed to cold. | 1957 | 13453456 | |
| the supplementary value of certain processed protein foods based on blends of groundnut, soya-bean, sesame, chick-pea (cicer arietinum) flours and skim-milk powder to a maize--tapioca diet. | 1962 | 14452512 | |
| influence of estradiol-17-beta, progesterone and hydrocortisone on 3-methylcholanthrene-induced mammary cancer in intact and ovariectomized sprague-dawley rats. | 1963 | 14068828 | |
| the metabolism of mucopolysaccharides. i. adrenal steroids and the synthesis of glucosamine-6-phosphate. | 1963 | 14083978 | |
| dietary protein level and the turnover rate of tissue proteins in rats. | 1963 | 14101006 | |
| skin response to solenamine, a hemolytic component of fire-ant venom. | 1963 | 14156164 | |
| deposition of benzo(a)pyrene in mouse fat after oral administration. | 1964 | 14115696 | |
| effects of sex steroids on the choline acetylase activity in the hypothalamus of female rats. | 1964 | 14168328 | |
| a study of the uterine cervix of the mouse. | 1964 | 14218417 | |
| inhibitory effect of testosterone on luteinizing hormone secretion in immature and adult rats. | 1965 | 14268458 | |
| action of fats and linoleic acid on intestinal synthesis of thiamine in thiamine-deficient rats. | 1965 | 14290858 | |
| influence of two contraceptives on induction of mammary cancer in rats. | this study assesses the influence of 2 popular oral contraceptive (oc) agents that seem to act like progesterone in the induction of mammary cancer in rats. 35 day old rats were maintained on a diet of wayne lab-blox ad lib, which was tested by the manufacturer for freedom from estrogen. at 48 days, 1/2 of the rats were subjected to bilateral oophorectomy. at 49 days, all of the animals except the control group were started on one of the 2 ocs, either enovid or norlestrin at 2 different dosag ... | 1965 | 5862377 |
| effect of preservatives on the heat sterilization of sesame oil. | 1967 | 4964774 | |
| the availability of calcium from mexican and californian sesame meals. | 1967 | 4965061 | |
| amino acid supplementation of a sesame meal diet. | 1967 | 6081748 | |
| reduction of carcinogen-induced breast cancer in rats by an anti-fertility drug. | the dmba (dimethylbenz[a]anthracene)-induced mammary cancer systems seemed to be an ideal model for the study of the influence of oral contraceptives (ocs) on endocrine-related cancers. groups of 20 female sprague-dawley rats, age 40-45 days, weight approximately 150 g, were given 3.0 or 0.3 mg of crystalline enovid suspended in 1 ml of sesame oil per dose for 45 days. the controls consisted of a group of 20 rats given a single dose of 15 mg of dmba, of 2 groups of 10 rats administered daily d ... | 1968 | 5641718 |
| studies on sesame oil cake meal (sesamum indicum) in chick mash. | 1968 | 5693493 | |
| histological study on norethynodrel treated rat ovary. | in an attempt to disclose the antiovulatory mechanism of norethynodrel, a progestational compound having slight estrogenic action, a histological study of treated rat ovaries was made. 4 test animals were injected daily for 14 days with 1 mg of norethynodrel in .3 ml sesame oil. all were killed 24 hr after the last injection. ovaries of treated rats showed follicular degeneration (cystic atresia), interstitial cell degeneration, and cellular hypertrophy of lutein cells. immature follicles di ... | 1968 | 12254411 |
| changes in structure and function of the preputial glands following daily injections of estrone or testosterone propionate in ovariectomized, "normal" and neonatally estrogenized rats. | these experiments were undertaken to determine if there is any difference in response of the preputial glands to estrogen or androgen between neonatally estrogenized adult female rats when ovariectomized and normal female rats similarly ovariectomized. 23 sprague-dawley females were given daily injections of estrone for 20 days from day of birth. doses were 50 mcg in .2 ml sesame oil for the first 10 days and 100 mcg in .04 ml of oil for the next 10 days. these are referred to as estrogenize ... | 1970 | 12304872 |
| amino acid supplementation of a protein-rich mixture of crushed groundnut, chickpea and sesame. | 1970 | 5418186 | |
| the amino acid sequence of sesame (sesamum indicum l.) and castor (ricinus communis l.) cytochrome c. | the amino acid sequences of sesame (sesamum indicum l.) and castor (ricinus communis l.) cytochrome c were determined by using 1.5mumol of protein from each species. both molecules consist of a single chain of 111 amino acid residues and are homologous with other mitochondrial cytochrome c molecules. both have an n-acetylated ;tail' of eight amino acids and two in-n-trimethyl-lysine residues, as also reported for wheat germ (delange, glazer & smith, 1969) and mung-bean cytochrome c (thompson, la ... | 1971 | 5119781 |
| [the possible use of sesame flour for human consumption]. | 1971 | 5136115 | |
| influence of quinestrol on th histology and phosphatase activity of the simian uterus. | the purpose of this study was to evaluate the endometrial acid and alkaline phosphatase activity in rhesus monkeys chronically treated for 24 months with 3 levels of quinestrol (17-ethynlestradiol cyclopentyl ether). the 3 levels were: 1) 4 animals, 4 mcg/kg;2) 3 animals, 20mcg/kg; 3) 4 animals 100 mcg/kg. there were 4 animals included as sesame oil controls. all monkeys receiving quinestrol had some degree of cystic endometrial hyperplasia, dose-related, ranging from trace, to weak, to moder ... | 1971 | 4994113 |
| studies of dimethylpolysiloxane compared to sesame oil as a vehicle for progesterone injection. | 1972 | 5029461 | |
| effect of histidine on tibia alkaline phosphatase of chicks fed zinc-deficient sesame meal diets. | 1972 | 5074345 | |
| the effect of copper salts on ovulation, especially on hypothalamic ovulatory hormone releasing factor. | in this study the influence of copper salts on the hypothalamic ovulatory hormone releasing factor was studied in vivo. 321 healthy adult female rabbits were used. 85 mcg of estradiol-17-beta-benzoate dissolved in 1 ml of sesame oil was injected intramuscularly for 2 days. absence of ovulation and an active corpus luteum were confirmed by laparotomy. (for the measurement of lh rats were injected with 1000 iu of pms and 64 hours later with 50 iu of hcg subcutaneously. bioassay was conducted ... | 1972 | 4648397 |
| nitrogen retention of adult human subjects who consumed wheat and rice supplemented with chickpea, sesame, milk, or whey. | 1973 | 4800394 | |
| nitrogen transformation in soils. ii. in sandy soil under horse-bean and sesame in a two years' rotation. | 1973 | 4353660 | |
| the lysine requirement of growing chicks fed sesame meal-gelatin diets at three protein levels. | 1973 | 4709408 | |
| effect of aureofungin on seedling mortality and growth of two varieties of sesame with seed-borne infection of fusarium solani. | 1973 | 4763647 | |
| tetrahydrocannabinol, sesame oil and biogenic amines: a preliminary report. | 1974 | 4407739 | |
| effect of dehulling and heat processing on nutritional value of sesame proteins. | 1974 | 4826076 | |
| direct action of estradiol on rat mammary tumors. | this study reports a direct action of 17-beta-estradiol on protein synthesis by 7, 12-dimethylbenz (alpha) anthracene (dmba) induced rat mammary tumors. sprague-dawley female rats were given 20 mg of dmba in sesame oil by gastric tube. mammary tumors developed. when tumors reached 1.5 to 2 cm in diameter, animals were ovariectomized. at 4-7 days later animals were killed and tumors removed. microscopic examination confirmed the tumors to be carcinoma of adenoid cystic variety with regressiv ... | 1974 | 4855761 |
| efficiency and regulation of water transport in some woody and herbaceous species. | the efficiency with which plants transport water is related to the water potential differences required to drive water fluxes from the soil to the leaf. a comparative study of two woody and three herbaceous species (citrus sinensis l. cv. koethen, pyrus kawakami l., helianthus annuus l. cv. mammoth russian, capsicum frutescens l. cv. yolo wonder, and sesamum indicum l. cv. glauca) indicated contrasts in water transport efficiency. depression of leaf water potential in response to transpiration i ... | 1974 | 16658853 |
| ovarian steroids directly alter luteinizing hormone (lh) release by pituitary homografts. | the direct role of estradiol and progesterone in sensitizing the adenohypophysis to the releasing action of lhrh (luteinizing hormone-releasing hormone) has been examined in rats bearing pituitary homografts. groups (10-14/group) of virgin female rats (cdf) strain) were hypophysectomized, ovariectomized, and pituitaries obtained from long-term ovariectomized donors were implanted under the kidney capsule. the animals were treated on the sixth day after transplantation with sesame oil vehicle, es ... | 1975 | 1095356 |
| morphometric evaluation of sebaceous gland volume in intact, castrated, and testosterone-treated rats. | starting a 19 weeks of age six male rats, castrated at 16 weeks, were injected intramuscularly three times per week with 0.25 mg testosterone propionate (dissolved in sesame oil) per 100 grams body weight. four castrated control rats received sesame oil only. samples of dorsal skin were taken under light ether anesthesia at the time of orchidectomy and at weekly intervals during treatment. histologic sections were cut perpendicular to the skin surface, stained with hematoxylin and eosin, and an ... | 1975 | 1110306 |
| maintenance of rate testis fluid testosterone and dihydrotestosterone levels by pregnenolone and other c21 steroids in hypophysectomized rats. | this study was undertaken to determine whether maintenance of spermatogenesis in hypophysectomized rats by pregnenolone and other c21 steroids may be due to in vivo conversion of these compounds to androgens. hypophysectomized rats were treated sc with 2 mg of pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone or testosterone propionate in 0.2 ml sesame oil daily for 14 days beginning 2 days after hypophysectomy. rete testis fluid (rtf), peripheral blood, and testicular v ... | 1975 | 1126312 |
| effects of delta-9-tetrahydrocannabinol administered subcutaneously to rabbits for 28 days. | subcutaneous (s.c.) administration of delta-9-tetrahydrocannabinol (delta-9-thc) to rabbits produced dose-related cumulative toxicity. five groups of three new zealand albino rabbits each received 28 daily treatments with isotonic saline, sesame oil of 15.9, 45.0 or 153.4 mg/kg/day of delta-9-thc dissolved in sesame oil. dose-related dermal responses included erythema, edema, ulceration and nodule formation. some of the granulomatous nodules contained an oily substance and exhibited liquefactive ... | 1975 | 1129806 |
| [morphological effects of intraperitoneal oily fatty acids on the intestine and peritoneum of rats]. | changes of the mucosa of the small intestine in animal experiments can be produced by a variety of methods. the direct application of numerous chemical agents on the epithelium of the mucosa and parenteral administration of cytostatics as well as an indirect damage by experimental intestinal lymphatic obstruction lead to mucosal lesions with atrophy of the villi. our paper presents a simple indirect method for induction of structural mucosa changes in rats using experimentally produced peritonea ... | 1975 | 1131154 |
| effect of exposure to continuous light on estrogen-induced precocious sexual maturation in female rats. | immature female rats, raised in either cyclic light (ld; 14 h light/10 h dark) or constant light (ll) were divided into 4 groups and given daily injections of estradiol benzoate (5, 10, or 25 ng) in 0.1 ml sesame oil starting at 24 days of age. control animals received oil only. injections were continued until vaginal opening (v.o.). half of each group of animals was killed and dissected 1 day after v.o. results indicate that both ll exposure and eb treatment accelerated sexual maturation (as in ... | 1975 | 1143631 |
| androgenization: alterations in the mechansim of oestrogen action. | total nuclear uptake of oestradiol, specific nuclear binding of oestradiol and oestrogen-induced proteins were studied in the uterus of femal sprague-dawley rats injected on postnatal day 3 with sesame oil or with 1-25 mg of testosterone propionate in sesame oil (androgenization). total uptake of radioactivity was lower than normal in nuclei from uterine homogenates of androgenized females but was increased by the addition of excess cytosol from normal uterus. these data suggest that androgeniza ... | 1975 | 1165442 |
| a circadian rhythm of mitotic activity in the uterine luminal epithelium of the rat: effect of estrogen. | the study was designed to determine whether or not the rat uterine luminal epithelium exhibits a mitotic circadian rhythm and to ascertain the effect of estrogen treatment at different time periods on the uterine epithelial mitotic response. immature rats were injected with either sesame oil (controls) or 60 ng of estradiol-17 beta at eight time periods and were necropsied 24 hours after treatment. colchicine was administered ip two hours before autopsy. peak mitotic activity was observed during ... | 1975 | 1200410 |
| metabolizable energy (m.e.) values of three protein supplements as determined with chicks and laying hens. | the m.e. values of three protein supplements that are produced and/or processed in lebanon and jordan were determined employing the method of hill and anderson (1958). two experiments were conducted using broiler-type chicks in one experiment and white leghorn laying hens in the other experiment. nitrogen-corrected m.e. values expressed in kcal./kg. dry matter were found to be 2513, 2690 and 3215 for the soybean, sesame and poultry by-product meals, respectivel, as determined with chicks, and 25 ... | 1975 | 1228719 |
| [effects of ethinyl estradiol compared with norethisterone (pure or contaminated) on vaginal keratinization of castrated rats]. | norethisterone samples are often contaminated by estrogen traces which can be measured by mass spectrometry and which invest the progestative with estrogenic properties in the allen and doisy test. therefore, one had better, in pharmacodynamic experimenting, use samples that have been purified by chromatography or that are pure out of synthesis. however, one will not forget these are not without some estrogenicity, a fact which seems linked to the very nature of the norethisterone molecule. | 1975 | 126774 |
| [distribution of bleomycin in sesame oil suspension in organs of rat with mammary carcinoma induced by 7,12-dimethylbenz (a) anthracene and its effect on the tumors (author's transl)]. | distribution of the bleomycin a2 suspended in sesame oil (oil bleo suspension) in rat organs and tumors after the intramuscular administration was investigated by bioassay, the effect of intratumor administration of the suspension on the growth of rat mammary carcinoma induced by 7, 12-dimethylbenz (a) anthracene was also studied. the oil suspension showed a protracted concentration in either tumor or organ tissues, but showed similar inhibitory effects on rat mammary carcinoma to those by regul ... | 1975 | 53298 |
| [effect of continuous bleomycin treatment and of oil-suspended bleomycin on experimental tumor growth (author's transl)]. | effects of continuous administration of bleomycin solution and of intralesional injection of sesame oil-suspended bleomycin on tumor growth were studied. experimental animal tumors were 3 rd generation isotransplants of a spontaneous c3h mouse mammary carcinoma. bleomycin treatments were started when transplanted tumors reached 8 mm in diameter and the measurement of tumor volume was followed. dose administered was fixed as 100 mg/kg in all the groups. bleomycin solution was given intralesionall ... | 1976 | 60500 |
| effect of melatonin on the reproductive systems of male and female syrian hamsters: a diurnal rhythm in sensitivity to melatonin. | hamsters were maintained on a long photoperiod (14l:10d) and were injected once daily with melatonin (10-25 mug) or sesame oil. males which received melatonin during the afternoon (e.g., 6.5-13.75 h after lights-on) showed regressed testes and decreased levels of serum lh and fsh after several weeks of treatment. injections of the oil vehicle or injections of melatonin given in the morning (3 h after lights-on) had no detectable effect on testicular size or on serum gonadotropins. females which ... | 1976 | 1033827 |
| factors in diminution of uteroglobin secretion in the rabbit. | uteroglobin was measured under various hormonal conditions: pregnancy, pseudopregnancy, pseudopregnancy with exogenous progesterone, pseudopregnancy with exogenous 20alpha-hydroxyprogesterone, ovariectomy with exogenous progesterone, ovariectomy with exogenous estrogen, ovariectomy with exogenous estrogen and progesterone, and ovariectomy with either exogenous progesterone or estrogen and progesterone, plus uterine trauma. in pregnant females, uteroglobin levels diminished sharply after day 9. i ... | 1976 | 1245243 |
| induction of vaginal mucification in rats with testosterone and 17beta-hydroxy-5alpha-androstan-3-one. | based on histological criteria, kingsley and bogdanove (3) reported that the benzoate ester of 17beta-hydroxy-5alpha-androstan-3-one (5alpha-dht), unlike testosterone propionate, is unable to induce vaginal mucification when given subcutaneously to rats. in contrats, kennedy (4) found in estrogen-pretreated rats that both 5alpha-dht and testosterone induced vaginal mucification as indicated by increased vaginal sialic acid concentration. to determine if esterification of these androgens altered ... | 1976 | 1265800 |
| release and elimination of 14c-fluphenazine enanthate and decanoate esters administered in sesame oil to dogs. | the rates of release of 14c-fluphenazine enanthate and 14c-fluphenazine decanoate were compared in two groups of five male dogs. each dog was given a single dose (2 mg/kg im) of either the enanthate or decanoate ester in sesame oil. the times required to attain maximum concentrations of radioactivity in plasma were 3.8 +/- 0.5 days (+/-se) for the enanthate ester and 10.6 +/- 1.1 days for the decanoate ester (p less than 0.001); maximum concentrations of radioactivity in the plasma at these time ... | 1976 | 1271246 |
| natural occurrence of fusarium toxins in feedstuff. | the mycotoxins diacetoxyscirpenol, deoxynivalenol, and zearalenone, produced by fusarium roseum, were found naturally occuring in mixed feed samples. in all cases analyzed, deoxynivalenol occurred together with zearalenone. the natural occurrence of zearalenone in sesame seed is reported for the first time. strains of f. roseum isolated in various parts of the world form feed implicated in animal mycotoxicosis produced monoacetoxyscirpenol, diacetoxyscirpenol, deoxynivalenol, and zearalenone. | 1976 | 984829 |
| serum corticosterone in rats with delayed anovulation. | the purpose of this study was to investigate adrenal function in rats during the development of persistent oestrus to determine whether a change in blood levels of corticosterone would precede or coincide with the onset of infertility. the syndrome of delayed persistent oestrus and anovulation was induced by administration of a low dose (10 mug) of testosterone propionate (tp) at 5 days of age. control animals were handled without injection or received the vehicle (sesame oil) only. half of each ... | 1976 | 988105 |
| experimental gastric ulcers in the fundic gland area following transplantation of the gastric-wall pedicles. | using adult mongrel dogs, a portion of the anterior gastric wall of the pyloric gland area was transplanted into the fundic gland area using the z-plastic procedure forming an islet. three weeks postoperatively, 2 per cent histamine in sesame oil was injected intramuscularly in a daily dose of 2 mg/kg body weight. ulcers developed in the graft in nine of 19 animals. the factors responsible to the development of the ulcers may well be circulatory disturbance and reduction of mucosal resistance fo ... | 1976 | 1034834 |
| testosterone manipulations: effects on ranacide aggression and brain monoamines in the adult female rat. | the effect of testosterone propionate on ranacide (frog-killing) behavior and brain norepinephrine (ne), dopamine (da) and serotonin (5-ht) levels was determined in 40 female wistar rats. adult rats were screened for frog killing behavior on the basis of a single 30 min testing session. aggressors were defined as animals which attacked or killed during this session while nonaggressors failed to do so. using either aggressors or nonaggressors, testosterone and sesame oil equally increased aggresi ... | 1976 | 1083535 |
| experience of nasal application of inactivated influenza vaccine. | the present experiment shows the efficacity of the sesame-oil adjuvant influenza vaccine. the plain inactivated vaccine merely shows a tendency towards effectiveness and only in a field study was a statistically significant effectiveness observed. we had hitherto made such a field experiment in which the plain inactivated influenza vaccine showed much more effective values. it is not clear that in the present experiment such a result was obtained. the efficacy of intranasal application of inact ... | 1976 | 782963 |
| serum lh and fsh levels following intravenous injection of a gonadotrophin releasing principle in normal and gonadectomized adult male rats treated with oestradiol-17beta or 5alpha-dihydrotestosterone. | effect of intravenous administration of a synthetic gonadotrophin releasing factor (gnrf) on circulating lh and fsh concentrations was investigated in normal and gonadectomized, adult male rats injected subcutaneously each day during seven days with various doses of oestradiol-17beta or 5alpha-dihydrotestosterone in sesame oil. higher increase in serum lh and fsh levels subsequent to intravenously administered gnrf was observed in castrated control animals than in intact control animals, though ... | 1976 | 790885 |
| oncogenicity of k-region epoxides of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene. | female sprague-dawley rats were given a subcutaneous injection of the parent hydrocarbon or its k-region epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. the parent compounds, benzo(a)pyrene (0.2 mumole/dose) and 7,12-dimethylbenz(a)anthracene (0.2 mumole/dose), induced sarcoma in 100% of the animals with an average latent period of 101 and 95 days, respectively, whereas five of 12 rats (42%) injected with the k ... | 1976 | 821865 |
| the toxicity of brominated sesame oil and brominated soybean oil in miniature swine. | miniature swine were fed brominated sesame oil at dietary levels of 0, 5, 25, 50 or 500 mg/kg of body weight for 17 weeks and brominated soybean oil at levels of 0, 5, 50 or 500 mg/kg of body weight for 28 weeks. growth rate and food intake were decreased only at the high dose level in the brominated sesame oil study. in both studies, signs of lethargy and ataxia occurred in pigs fed the highest dose, and were probably due to a dose-related increase in serum bromine concentrations. marked elevat ... | 1976 | 944471 |
| organic amendments and control of foot rot of piper betle caused by phytophthora parasitica var. piperina. | experiments have been performed to control foot rot of piper betle by organic amendments and antagonists in soil. soil amended with corn straw gave best control. corn straw supplemented with nitrogen (nh4no3) gave still better control. the effect of different antagonists growing on corn-straw and til (sesamum indicum) oil cake amendments showed that trichoderma viride gave best control. aspergillus terreus failed to control the disease although it showed great antifungal activity under controlle ... | 1976 | 952442 |
| in vivo and in vitro evaluation of a microencapsulated narcotic antagonist. | injectable microcapsules containing 75% (w/w) cyclazocine, a narcotic antagonist, were prepared with dl-poly(lactic acid) as the coating material. capsule fractions falling between 105 and 295 mum released about 90% of their cyclazocine in 8 days of rotating-bottle extraction at 37 degrees in ph 7.4 phosphate buffer. although larger capsules released the drug somewhat more slowly, all capsules released cyclazocine far more rapidly than an ideal capsule should. this rapid release is attributed to ... | 1976 | 932970 |
| changes in the weight of the adrenal glands and in the concentration of plasma corticosterone in perinatal rats after prenatal treatment with oestadiol benzoate. | on day 20 of gestation, foetal rats received a subcutaneous injection of 0-01 mg oestradiol benzoate dissolved in 0-05 ml sesame oil; foetuses in other litters were given sesame oil alone. autopsy was performed on day 22 of gestation, at delivery or at various times after birth. gravimetric and histological observations of the adrenals from oestradiol-treated, oil-treated and intact litter-mate control foetal and neonatal rats were performed together with determination of plasma corticosterone c ... | 1976 | 950534 |
| fluphenazine enanthate and fluphenazine decanoate: intramuscular injection and esterification as requirements for slow - release characteristics in dogs. | 14c-fluphenazine base was administered intramuscularly in sesame oil to five male beagles (2 mg/kg). the concentration of radioactivity in plasma and the excretion of radioactivity in urine and feces were measured for 14 days. maximum concentrations of radioactivity were found in plasma 2 hr after administration. these levels declined with elimination half-lives of 3.20 hr during the 2-12-hr interval after dosing and of 4.02 days during the 2-14-day interval. most administered radioactivity was ... | 1976 | 966144 |
| failure of estradiol benzoate given after birth to prevent the adrenal glands from shrinking in newborn rats. | two hr after birth, newborn rats were given a subcutaneous injection of 0.01 mg estradiol benzoate dissolved in 0.05 ml sesame oil. other siblings were given sesame oil alone. autopsy was performed on days 1, 2 and 3 after birth. gravimetric and histologic examinations of the adrenals from these animals and from normal littermate controls were made together with the determination of plasma corticosterone concentrations. in all the three groups of rats, estrogen-treated, oil-treated and non-treat ... | 1976 | 1009895 |
| abolition of the diethylstilbestrol reduction of enzyme leakage from muscle by a 3,3' diallyl substitution. | diethylstilbestrol (des) lowers enzyme efflux from isolated mouse skeletal muscle. it also lowers the high serum enzyme activities in duchenne's muscular dystrophy. we have begun a systematic study of des congeners, to identify those portions of the des molecule which are critical to these effects, and to tailor a molecule which might have fewer feminizing effects. the first compound tested was the 3,3' diallyl derivative of des (das). it was selected because previous reports indicated that it w ... | 1977 | 897342 |
| effects of threonine supplementation on the slope assay for protein quality. | several diets considered to be marginally deficient in threonine were fed to young male rats at protein levels ranging from 3 to 9%. protein sources included lactalbumin (reference standard), soy protein with added methionine, pea protein with added methionine, rice-casein, and peanut-sesame-fish. chemical scores and plasma amino acid scores indicated that these diets were limiting in threonine at the 3--4% protein level; increased growth resulted from supplementation with threonine. after threo ... | 1977 | 924931 |
| [selenium content in the blood cattle from venezuela. i. central and portugueste zones]. | whole blood concentrations of selenium were determined in 776 dairy cows and calves from 28 farms located in three states (aragua, carabobo and guárico) of the central zone of venezuela and in portuguesa state. selenium levels largely varied according to both the geographic distribution and animals breed. cattle from guárico state showed the lowest average concentration (0.21 ppm) and those from portuguesa the highest one (0.67 ppm). a group of animals from turén (a district of portuguesa state) ... | 1977 | 931500 |
| influence of fasting on the absorption and effects of delta9-tetrahydrocannabinol after oral administration in sesame oil. | tissue levels of 3h were higher 2 hr after oral administration of 3h-delta9-thc (10 mg/kg in sesame oil) to male fischer rats in the morning compared with treatment in the afternoon. a corresponding reduction in potency was seen for the impairing effect of delta9-thc on performance of a conditioned avoidance response (car). the hypothesis that these effects were related to the interval between feeding (which normally occurs during the night in the nocturnal rat) and drug administration was suppo ... | 1977 | 558623 |
| fertility of norgestomet treated dairy heifers. | four studies are described involving 2573 friesian heifers treated with norgestomet and oestradiol valerate to control the ovarian cycle. all treated animals were inseminated at fixed times following treatment. in study 1 insemination 48 and/or 60 hours after treatment resulted in a non-significant greater proportion of heifers becoming pregnant than at 48 x 72 hours. large variations in fertility among farms were recorded in field trials of norgestomet (searle) and oestradiol valerate. in study ... | 1977 | 878243 |
| morphology, growth characteristics and oestrogen-binding capacity of dmba-induced mammary tumours from ovariectomized rats. | the morphology of 20 mammary adenocarcinomas induced by 7,12-dimethylbenz(a)anthracene (dmba) in sprague-dawley rats was compared with their growth characteristics and oestrogen-binding capacity following ovariectomy. the capacity to bind (3h)oestradiol-17b did not appear to be related to the growth characteristics, time of appearance after dmba administration, or time between ovariectomy and assay for specific oestrogen-binding proteins. furthermore, different tumours appeared to have oestrogen ... | 1977 | 405032 |
| effect of progesterone on the initiation of respiration of the newborn. | on the 30th day of pregnancy, the experimental fetuses in 19 rabbits were injected intraperitoneally with 0.1-1.0 mg progesterone (p). the control fetuses in the contralateral uterine horn were treated with the solvent, sesame oil. both the experimental and control fetuses were delivered 10 min after treatment by hysterotomy to measure the p concentration of their lung tissue and observe their respiration during the initial 2 h of postnatal life. in comparison with the controls, the experimental ... | 1977 | 245313 |
| estrogen receptors in androgen-induced breast tumor regression. | the hormone-dependent 7,12-dimethylbenz(a)anthracene rat mammary tumor has been shown to regress when administered pharmacological doses of testosterone propionate. tumor regression was correlated with estrogen receptor before and 15 to 20 days following testosterone therapy. a dramatic decline of receptor occurred in all regressing tumors, whereas those administered sesame oil alone maintained both growth and receptor content. although receptor in regressing tumor was significantly less than in ... | 1977 | 192456 |
| effects of aldosterone on the urinary excretion of total and non-dialyzable hydroxyproline. | in order to explore the role of mineralocorticoids on collagen metabolism, the effects of aldosterone on the urinary excretion of total and non dialyzable hydroxyproline (hypro) was studied in rats. the administration of aldosterone in sesame oil, 75 microgram/100 g body weight to adrenalectomized rats maintained on 1% nacl solution as drinking fluid and 1 mg of cortisone subcutaneously daily, provoked elevation of total and non dialyzable hypro in urine (p less than 0.001), when compared to sim ... | 1977 | 590925 |
| purification, crystallization and properties of triacylglycerol lipase from pseudomonas fluorescens. | triacylglycerol lipase of pseudomonas fluorescens was purified from the crude enzyme by ammonium sulfate precipitation and chromatographies on sephadex g-75 and deae-cellulose. the crystallization of the lipase was successfully carried out. the purified lipase was demonstrated to be homogenous on disc electrophoresis and its molecular weight was calculated to be 32 000 by gel filtration. the optimum ph for hydrolysis of sesame oil was 7.0. the enzyme was stable up to 40 degrees c under the condi ... | 1977 | 20147 |
| esters of 4-3-2-(trifluoromethyl)phenothiazin-10-ylpropyl-1-piperazieneethanol and related compounds as long-acting antipsychotic agents. synthesis of the 1-adamantoate, the first crystalline base. | a number of new esters of fluphenazine are described: among these was the 1-adamantoate, 1h, the first highly crystalline ester of that drug. the 1-adamantoate of pipotiazine, 2b, typically, was an oil. following a single subcutaneous or intramuscular injection of 25 mg/kg of either 1h or 2b, dissolved in sesame oil, each ester was found to be a potent and long-acting inhibitor of conditioned avoidance behavior in the rat. | 1977 | 13218 |
| neonatal treatment with sex steroids: relationship between the uterotropic response and the estrogen "receptor" in prepubertal rats. | we tested the hypothesis that neonatal treatment of rats with testosterone propionate (tp) or estradiol benzoate (eb) reduces the uterine responsiveness to estradiol and reduces the concentration of estrogen "receptor" before puberty, and that both of these events precede the onset of the persistent estrus syndrome. thre-day-old female rats were injected with 100 mug eb, tp or sesame oil (controls) and at 23 and 31 days of age (before the onset of puberty) the uterine cytoplasmic content of spec ... | 1977 | 12934 |
| determination of ethinyl estradiol in human urine by radiochemical glc. | a radiochemical glc analysis was developed for 3h-labeled ethinyl estradiol in human urine. the technique was applied to the unconjugated and aglycone fractions of urine collected from women who were dosed orally with: (a) single capsules containing 2.0 mg of 3h-quinestrol (900 muci) and 2.5 mg of unlabeled quingestanol acetate dissolved in sesame oil and (b) single tablets containing 100 microgram of 3h-quinestrol (86 muci). unconjugated ethinyl estradiol in day 1 urine collections represented ... | 1978 | 671253 |
| oxytocin-stimulated production of prostaglandin f2alpha by isolated endometrium of rabbit: modulation by ovarian steroids. | to test the hypothesis that ovarian steroid hormones modulate oxytocin-induced release of prostaglandin f2alpha (pgf2alpha) from uterine endometrium, 2 ovariectomized rabbits were pretreated with progesterone (5 mg/day for 10 days), 2 with estradiol-17 beta (25 microgram/day for 10 days), 2 with both steroids, and one with sesame oil only. on the last day of treatment, endometrial fragments were excised and incubated in vitro with or without oxytocin (100 muu/ml). although endometrium from rabbi ... | 1978 | 625567 |
| effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat. | young adult cyclic female rats were each injected with 2 mg estradiol valerate (ev) in sesame oil. controls received an equivalent volume of sesame oil. within 2 months after injection, most of the ev-treated animals showed persistent vaginal estrus and small polyfollicular ovaries as well as pathological changes in the hypothalamic arcuate nucleus. this pathological process was gradually progressive such that by 6 months after ev injection, the basal lateral region of the nucleus contained nume ... | 1978 | 744098 |
| effect of testosterone and progesterone on the estradiol receptor in the immature rat ovary. | the effect of testosterone and progesterone on the estrogen-stimulated ovarian weight increase and es tradiol receptor (er) levels was examined in immature, hypophysectomized rats. nuclear translocation and cytosol replenishment of the er in the ovary exhibited similarities to those events in the uterus. the ovarian weight increase observed on day 4 in response to three daily injections of 2.5 microgram 17beta-estradiol administered sc in sesame oil was effectively suppressed by one injection of ... | 1978 | 744008 |
| steroidogenesis in rat leydig cells: effect of gonadotropins on the activity of 5-ane and 5-ene 3alpha- and 3beta-hydroxysteroid dehydrogenases during sexual maturation. | the in vivo influence of gonadotropins on the activities of oxidoreductases of androst-5-ane and androst-5-ene steroids and pregnenolone was examined in testes from young rats. animals were given daily injections of human cg for 5 days starting at 20 days of age and the testicular 12,000 x g supernatants were assayed for steroid oxidoreductase activities. marked increases (up to 8-fold) were noted in the rate of oxidation of the 3beta-hydroxyl of 3beta-hydroxy-5beta-androstan-17-one, 3 beta-hydr ... | 1978 | 743993 |
| comparative bioavailability of a lipophilic steroid. | 17beta-acetoxy-2alpha-chloro-3-(p-nitrophenoxy)imino-5alpha-androstane (i) is a lipophilic steroid with postimplantive antifertility activity in laboratory animals. the bioavailability of micronized i from solutions and suspensions was compared in four groups of adult female wistar rats. each group received varying concentrations of micronized 3h-i (specific activity of 0.38--8.94 muci/mg) in sesame oil by oral gavage. samples of whole blood and urine collected following drug administration were ... | 1978 | 690835 |
| evaluation of prenatal androgen and ovarian secretions on receptivity in female and male rats. | offspring of rats infected daily from day 16 through day 20 of gestation with either 2 mg of testosterone propionate (tp) in .1 ml of sesame oil or oil alone were tested for sexual receptivity following injections of 3.3 microgram of estradiol benzoate (eb) and .5 mg of progesterone (p) beginning at 40, 80, or 120 days of age. at each age, neonatally gonadectomized males and females from tp-injected litters exhibited less receptivity than corresponding oil-injected controls. prenatally androgeni ... | 1978 | 566771 |
| studies on the adjuvant effect of water-in-oil-in-water (w/o/w) emulsion of sesame oil. 1. enhanced and persistent antibody formation by antigen incorporated into the water-in-oil-in-water emulsion. | water-in-oil-in-water (w/o/w) emulsion developed in our laboratory is as effective as water-in-oil (w/o) emulsion of freund's incomplete adjuvant (fia) in the stimulation of antibody formation. the emulsion is prepared by redispersion of water-in-sesame oil emulsion of an antigen solution in phosphate buffered saline with emulsifier, tween 80. the emulsion can be stored at 4 degrees c for at least 3 months without any evidence of change in the adjuvanticity and in the w/o/w state. even a single ... | 1978 | 713123 |
| sex hormones and the immune response. ii. perturbation of antibody production by estradiol 17beta. | the administration of 75 microgram/kg of estradiol 17beta at successively later stages in the immune response of female guinea pigs to penicilloyl-coupled cavian globulins showed that this steroid reduces the rate of attainment of the maximum titer, the magnitude of the titer achieved, and the rate of titer decay. control titers maximized at the third experimental week and diminished to one third the peak value by the 6th week. when steroid treatment was begun coincidentally with inoculation (we ... | 1978 | 680989 |
| buckthorn neuropathy: effects of intraneural injection of karwinskia humboldtiana toxins. | ingestion of the endocarp of the coyotillo fruit, karwinskia humboldtiana, a shrub of the buckthorn family, causes "buckthorn neuropathy" in man and animals. two neurotoxic compounds t496 and t544 were isolated from the endocarp and each toxin was dissolved in sesame oil and injected into the sciatic nerve of rats. the nerves were subsequently examined by teasing and as sections by light and electron microscopy. during the first 3--4 days after injection, oil droplets, probably containing toxin, ... | 1978 | 683463 |
| growth, phosphate pools, and phosphate mobilization of salt-stressed sesame and pepper. | the growth and phosphate mobilization of control and salt-stressed sesame (sesamum indicum l.) and pepper (capsicum annuum l.) plants were examined to ascertain whether or not translocation limits growth of salt-stressed plants. plants were grown in a complete nutrient solution with and without excess salt. one-half of the control and salt-stressed plants were later transferred to phosphate-free culture solution ("-p" plants). measurements of growth and phosphate pools in leaves indicated that w ... | 1978 | 16660491 |
| increased level of l-ascorbic acid in the plasma of poly-chlorobiphenyls-treated rats and its inhibition by dietary vitamin e. | one-month-old male rats were fed a basal vitamin e deficient diet with or without 100 ppm vitamin e supplementation for 11 weeks and were injected intraperitoneally with either 500mg/kg body weight of polychlorobiphenyls (pcb) in sesame oil or equivalent amount of sesame oil. five days after pcb treatment, the level of total l-ascorbic acid in the plasma of vitamin e deficient rats increased 69% (p less than 0.001) as compared with 26% (p less than 0.01) of the supplemented group. the dehydro fo ... | 1979 | 118502 |
| modifications induced by neonatal steroids in reproductive organs and behavior of male rats. | male rats injected on day 3 neonatally with .01, .1, 1, 10, 100, or 1,000 micrograms of estradiol benzoate (eb), 10,000 microgram of testosterone propionate (tp), or sesame oil were subsequently examined for testicular, penile, and accessory organ development. sexual behavior was evaluated during therapy with fluoxymesterone (fm) and then with tp. estradiol benzoate in dosages greater than 1.0 micrograms delayed testicular descent, reduced the size and hormone responsiveness of reproductive orga ... | 1979 | 457952 |
| sustained release of bcnu for the treatment of intraocular malignancies in animal models. | sustained release of 1,3-bis(2)chloroethyl)-1-nitrosourea (bcnu) via an episcleral implanted silicone device was used to treat brown-pearce epithelioma in the anterior chamber of rabbit eyes. one group of test eyes received bcnu dissolved in sesame oil; a second group received bcnu in pure ethanol. control eyes received only the diluent, sesame oil or pure ethanol. the effectiveness of the various dosages and diluents was compared by clinical observation, by weight of the enucleated eyes, and by ... | 1979 | 478776 |
| stimulation of dopamine release into hypophysial portal blood by administration of progesterone. | to test the hypothesis that progesterone is involved in the regulation of dopamine release into hypophysial portal blood, female rats were adrenalectomized and ovariectomized at 1200 h on the day of proestrus and, immediately after the operation, injected sc with sesame oil or progesterone. approximately 24 h later, hypophysial portal blood was collected and the plasma from this blood was analyzed for dopamine. the concentration of dopamine in portal plasma from rats given sesame oil or progeste ... | 1979 | 573202 |
| the androgenic effect on the fine structure on the harderian gland in the male hamster. | a sexual dimorphism of the hamster harderian gland at the ultrastructural level has been reported. the effect of testosterone on the fine structure of the gland from castrated male golden hamsters is reported here. harderian glands from the following three groups of animals were examined at regular intervals up to 60 days after castration: (1) castrated; (2) castrated-sham-injected, receiving 0.1 ml sesame oil per day; (3) castrated-testosterone-injected, receiving 2 mg testosterone propionate i ... | 1979 | 476787 |
| the interaction of cadmium-binding proteins (cd-bp) and progesterone in cadmium-induced tissue and embryo toxicity. | previous work indicates that a dimer of cd-thionein (cd-bp-d, 19,000 mw) is involved in the hereditary resistance to cd-embryotoxicity seen in the inbred naw/pr (naw) mouse strain. cd-bp-d is not detected in virgin females after cd exposure and is detected only after the first 24 hours of exposure to cd in an inbred strain (c57bl/10chpr) susceptible to cd-induced embryotoxicity (wolkowski, '74; wolkowski-tyl, '78). since progesterone (p) is critical for maintenance of pregnancy in mice, we have ... | 1979 | 232313 |
| administration of gonadal steroids to the castrated male rat prevents a decrease in the release of gonadotropin-releasing hormone from the incubated hypothalamus. | the influence of testosterone on gonadotropin-releasing hormone (gnrh) secretion was assessed indirectly by altering the serum testosterone concentration of male rats and measuring gnrh release from their incubated hypothalami 1 wk later.gnrh release from hypothalami of castrated rats was 13.4+/-1.2 (se) pg/h, compared to 35.3+/-3.8 pg/h from hypothalami of intact rats (p < 0.001). gnrh release from the hypothalami of castrated rats treated with testosterone propionate, 100 or 500 mug daily, was ... | 1979 | 372239 |
| anti-androgen tsaa-291. ii. manifestation of the anti-androgenic action of a steroid ester tsaa-330 (16 beta-ethyl-17 beta-hydroxy-4-oestren-3-one caproate) and elucidation of its long-lasting mechanism using a simple steroid determination technique. | using a simple steroid determination technique, in situ steroid absorption from a subcutaneously injected sesame oil solution in rats was pursued following the time-course changes in the steroid concentration. based on the knowledge thus obtained, the anti-androgenic effect of a steroidal compound, tsaa-330, could be manifested in the subcutaneous route. (1) anti-androgenic steroid tsaa-291 and its esters in the subcutaneously injected sesame oil solution were selectively absorbed into the gener ... | 1979 | 294105 |