| medicinal plants used in kirklareli province (turkey). | in this paper, 126 traditional medicinal plants from kirklareli province in turkey have been reported. one hundred and twenty six plant species belonging to 54 families and among them 100 species were wild and 26 species were cultivated plants. most used families were rosaceae, labiatae, compositae and the most used plants were cotinus coggyria, sambucus ebulus, achillea millefolium subsp. pannonica, hypericum perforatum, matricaria chamomilla var. recutita, melissa officinalis subsp. officinali ... | 2007 | 17257791 |
| transport of mistletoe lectin by m cells in human intestinal follicle-associated epithelium (fae) in vitro. | purified mistletoe lectins are known to have cytotoxic and stimulating activities in the immune system. mistletoe extract has been given subcutaneously because of its unstablity and poor absorption in the gastrointestinal (gi) tract. a hallmark of m cells is their capacity to internalize material from the lumen and to transfer it efficiently to the underlying lymphoid cells. although lectins are the prime candidates for oral vaccine delivery, the mechanisms whereby lectins are taken up, transpor ... | 2008 | 19099232 |
| comparison of viscum album qufrf extract with vincristine in an in vitro model of human b cell lymphoma wsu-1. | viscum album l. extract (iscador) with different preparations is used either alone or in combination with chemo/radiotherapy in the treatment of patients with various tumours.vincristine (cas 57-22-7) as a chemotherapeutic agent is used mainly in combination with other chemotherapeutic substances in the therapy of b cell lymphoma. in this study, the effects of viscum album (va) qufrf extract and vincristine were compared on b cell lymphoma cell line wsu-1 in an in vitro model. as parameters were ... | 2008 | 19137911 |
| effects of mistletoe (viscum album l., loranthaceae) extracts on arterial blood pressure in rats treated with atropine sulfate and hexocycline. | acute effects of different extracts of mistletoe stem (viscum album) were investigated on values of arterial blood pressure in wistar rats. arterial blood pressure was registered by direct method in the left carotid artery and the investigated extracts (total ethanol, ether and ethyl acetate) of mistletoe stem were administered into the right jugular vein. the total ethanol extract exhibited the best effect even on the lowest applied concentration (3.33 x 10(-5) mg kg(-1)) and significantly decr ... | 2009 | 19172455 |
| effects of korean mistletoe lectin (viscum album coloratum) on proliferation and cytokine expression in human peripheral blood mononuclear cells and t-lymphocytes. | the anti-cancer activity of mistletoe has been ascribed to a combination of cytotoxic and immunological effects. we previously showed that korean mistletoe lectin (viscum album l. var. coloratum agglutinin, vca) can stimulate ifn-gamma production and modulate proliferation in murine splenocytes. in this study, we investigated the effects of vca on human peripheral blood mononuclear cells (hpbmc) and t-lymphocytes. the addition of vca resulted in a significant inhibition of proliferation at highe ... | 2007 | 18038904 |
| mistletoe lectin modulates intestinal epithelial cell-derived cytokines and b cell iga secretion. | a galactose- and n-acetyl-d-galactosamine-specific lectin (viscum album l. var. coloratum agglutinin, vca), which is known for its anti-cancer activity, was isolated from korean mistletoe. in this study, iec-6 rat intestinal epithelial cells and im-9 human b-cells were cultured to determine the effect of vca on cytokine and immunoglobulin (ig) secretion. in lipopolysaccharide (lps)-stimulated iec-6 cells, vca significantly shifted the interleukin (il)-2, il-5, il-6, and tumor necrosis factor-alp ... | 2009 | 19387590 |
| the vasorelaxant effect of viscum album leaf extract is mediated by calcium-dependent mechanism. | viscum album leaf extract has a folk reputation as an antihypertensive agent in nigeria. evidence suggests that it has a relaxant effect on smooth muscle. the present study was designed to investigate the role of calcium in the vasorelaxant effect of this extract. concentration response studies to noradrenaline, kcl and cacl2 were carried out in rat aortic rings with and without the extract in physiological salt solution (n=6 each). also the role of intracellular calcium mobilisation was studied ... | 2008 | 19434226 |
| carbon reserves and canopy defoliation determine the recovery of scots pine 4 yr after a drought episode. | • severe drought may increase physiological stress on long-lived woody vegetation, occasionally leading to mortality of overstory trees. little is known about the factors determining tree survival and subsequent recovery after drought. • we used structural equation modeling to analyse the recovery of scots pine (pinus sylvestris) trees 4 yr after an extreme drought episode occurred in 2004-2005 in north-east spain. measured variables included the amount of green foliage, carbon reserves in the s ... | 2011 | 21261625 |
| improvement of an enzyme linked lectin assay to determine recombinant mistletoe lectin i. | extracts from viscum album leaves, with mistletoe lectin i (ml i) as the main therapeutic agent, are commonly used as an immunomodulating adjuvat in tumour therapy. because of its popularity against cancer and the possibility for a better standardisation a recombinant ml i (rml i) was developed by eck et al. to improve the sensitivity of an already established enzyme linked lectin assay (ella) for rml i human haptoglobins with different phenotypes (1.1, 2.1 and 2.2) are used to replace asialofet ... | 2007 | 16971084 |
| molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro. | viscum album (mistletoe) is one of the most widely used alternative cancer therapies. aqueous mistletoe extracts (mt) contain the three mistletoe lectins i, ii and iii as one predominant group of biologically active agents. although mt is widely used, there is a lack of scientifically sound preclinical and clinical data. in this paper, we describe for the first time the in vivo efficacy and mechanism of action of mt in lymphoblastic leukemia. for this purpose, we first investigated both the cyto ... | 2008 | 18314258 |
| calix[n]arene-based glycoclusters: bioactivity of thiourea-linked galactose/lactose moieties as inhibitors of binding of medically relevant lectins to a glycoprotein and cell-surface glycoconjugates and selectivity among human adhesion/growth-regulatory galectins. | growing insights into the functionality of lectin-carbohydrate interactions are identifying attractive new targets for drug design. as glycan recognition is regulated by the structure of the sugar epitope and also by topological aspects of its presentation, a suitable arrangement of ligands in synthetic glycoclusters has the potential to enhance their avidity and selectivity. if adequately realized, such compounds might find medical applications. this is why we focused on lectins of clinical int ... | 2008 | 18509838 |
| The Antimutagenic Effect of Mistletoe Lectin (Viscum album L. var. coloratum agglutinin). | A galactose- and N-acetyl-D-galactosamine-specific lectin (Viscum album L. var. coloratum agglutinin, VCA), which is known for its anticancer activity, was isolated from mistletoe. In this study, we investigated the antimutagenic potentials of VCA by using the pre-incubation method of the Ames test (Salmonella typhimurium TA98 and TA100) in the presence or absence of S9 mixture. Viscum album L. var. coloratum agglutinin was assessed for its antimutagenic properties against the mutagens 2-aminoan ... | 2011 | 22084060 |
| induction of maturation and activation of human dendritic cells: a mechanism underlying the beneficial effect of viscum album as complimentary therapy in cancer. | viscum album (va) preparations have been used as a complimentary therapy in cancer. in addition to their cytotoxic properties, they have also been shown to have immunostimulatory properties. in the present study, we examine the hypothesis that the va preparations induce activation of human dc that facilitates effective tumor regression. | 2008 | 18533025 |
| cytotoxic effects of the viscum album l. extract on ehrlich tumour cells in vivo. | to date most pharmacological studies on mistletoe (viscum album l.) have focused on the therapeutic properties of its polar extracts. this study examined the non-polar constituents of viscum album and their biological activities. supercritical co(2) extraction coupled with gas chromatography/mass spectrometry (gc/ms) was used to selectively extract and identify compounds in viscum album leaves. several non-polar classes of compounds were identified in the extract. in addition, a volatile fractio ... | 2008 | 18570233 |
| viscum album l. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. | viscum album l. extracts (vae, european mistletoe) are a widely used medicinal plant extract in gynaecological and breast-cancer treatment. | 2009 | 19519890 |
| antiangiogenic properties of viscum album extracts are associated with endothelial cytotoxicity. | viscum album (va) extracts are widely used in cancer therapy and are known to be cytotoxic to tumors and endothelial cells. angiogenesis plays an important role in the growth, sustenance and metastasis of tumors. inhibition of angiogenesis is now being explored as a new therapeutic avenue for cancer. | 2009 | 19661299 |
| immunomodulating effects of korean mistletoe lectin in vitro and in vivo. | the immunomodulatory effects of korean mistletoe lectin (kml), one of the major active components in viscum album l. var. coloratum, were investigated in vitro in immune cell proliferation and natural killer (nk) cell- and macrophage-mediated cytotoxicity, and in vivo in the forced swim test and cold stress. in mitogen-induced lymphocyte proliferation of murine splenocytes, concanavalin a and lipopolysaccharide significantly increased the proliferation of t cell and b cell lymphocytes, respectiv ... | 2009 | 19788934 |
| effects of european mistletoe (viscum album l. subsp. album) extracts on activity rhythms of the syrian hamsters (mesocricetus auratus). | antitumor drugs may have some significant nervous system side-effects such as disrupted sleep, eating and drinking patterns. european mistletoe has been investigated for many decades for its potential use against cancer. to test the hypothesis that the non-antineoplastic effects of mistletoe might be mediated by the actions on the circadian timing system, we have applied mistletoe extracts and vehicle and have measured locomotor activity, feeding and drinking rhythms under constant darkness. fou ... | 2008 | 18629716 |
| viscum album (mistletoe) extract prevents changes in levels of red blood cells, pcv, hb, serum proteins and esr in high salt-fed rats. | the present study was aimed to determine the effects of viscum album (mistletoe) on red blood cells, packed cell volume, hb content, absolute haematological values {mean corpuscular volume (mcv), mean corpuscular haemoglobin (mch), mean corpuscular haemoglobin concentration (mchc), colour index (ci)}, plasma proteins and esr in high salt-fed rats. | 2009 | 19818842 |
| assay of the cell-mediated immunity in patients with malignant and non-malignant diseases. | the depression of cell-mediated immunity (cmi) was determined in patients with ovarian and breast carcinomas by lymphokine production under con-a-stimulation (migration inhibitory factor), t-lymphocyte-transformation test under pha-stimulation and with a skin reactivity test with a viscum album extract (plenosol, dr. madaus, cologne, frg). the results show a good correlation between the different types of cmi function tests. the cytostatics have a depressive effect on cmi more through a cumulati ... | 2012 | 3309758 |
| the efficiency of viscum album ssp. album and hypericum perforatum on human immune cells in vitro. | viscum album l. ssp. album and hypericum perforatum l. are used for the treatment of different diseases. in this study, the effects of these herbals on immune cells were assessed in vitro. the phagocytosis, candidacidal activity of neutrophils and adhesion function of epithelial cells were investigated. also, the expression of the surface markers of lymphocytes was analyzed by flow cytometry. it was observed that v. album ssp. album increased phagocytic activity and candidacidal activity of neut ... | 2008 | 18668395 |
| application of direct pcr in rapid rdna its haplotype determination of the hyperparasitic fungus sphaeropsis visci (botryosphaeriaceae). | the plant pathogenic fungus, sphaeropsis visci a dark-spored species of botryosphaeriaceae, which causes the leaf spot disease of the european mistletoe (viscum album). this species seems to have potential as a tool for biological control of the hemiparasite. for the rapid detection of s. visci haplotypes we tested a direct pcr assay without prior dna purification. this approach was based on a polymerase enzyme from the crenarchaeon sulfolobus solfataricus engineered by fusion protein technology ... | 2014 | 25332869 |
| the effect of mistletoe, viscum album coloratum, extract on innate immune response of nile tilapia (oreochromis niloticus). | the purpose of the present study was to evaluate the effect of dietary mistletoe extracts on non-specific immune response and disease resistance of nile tilapia (oreochromis niloticus) against aeromonas hydrophila infection. tilapia fingerlings were fed with a diet containing 0 mg as a control, 10 mg, 50 mg, and 200 mg mistletoe powder kg(-1) dry diet for 80 days. the immunological parameters, respiratory burst activity, lysozyme activity, alternative complement haemolysis activity (ach(50)), an ... | 2012 | 22554573 |
| modular synthesis of amphiphilic janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to biomedically relevant lectins. | the modular synthesis of 7 libraries containing 51 self-assembling amphiphilic janus dendrimers with the monosaccharides d-mannose and d-galactose and the disaccharide d-lactose in their hydrophilic part is reported. these unprecedented sugar-containing dendrimers are named amphiphilic janus glycodendrimers. their self-assembly by simple injection of thf or ethanol solution into water or buffer and by hydration was analyzed by a combination of methods including dynamic light scattering, confocal ... | 2013 | 23692629 |
| influx of double labelled glutamine into mistletoes (viscum album) from the xylem sap of its host (abies alba). | the flux of glutamine into the mistletoe viscum album from the xylem sap of a coniferous host was analyzed. for this purpose, a perfusion system was used in which the xylem sap of the host was replaced by an artificial perfusion solution. with this system, flux rates into the mistletoe were determined in feeding experiments with the organic nitrogen source u(13)c/(15)n-gln. at the end of the experiments the delta values of c and n were significantly depleted in the outflow compared to the percol ... | 2016 | 17095236 |
| mistletoe lectin is not the only cytotoxic component in fermented preparations of viscum album from white fir (abies pectinata). | preparations of mistletoe (viscum album) are the form of cancer treatment that is most frequently used in the complementary medicine. previous work has shown that these preparations are able to exert cytotoxic effects on carcinoma cells, the extent of which might be influenced by the host tree species and by the content of mistletoe lectin. | 2007 | 17493268 |
| seasonal and spatial variation of carbohydrates in mistletoes (viscum album) and the xylem sap of its hosts (populus x euamericana and abies alba). | in the present field study we analysed the seasonal pattern of carbohydrate composition and contents in the xylem sap of viscum album and the xylem sap of a deciduous (populusxeuramericana) and a coniferous (abies alba) host tree species. the results were compared with the soluble carbohydrate composition and contents of mistletoe tissues. on both hosts significant amounts of glucose, fructose, and sucrose were found in the xylem sap of viscum throughout the seasons. the general seasonal pattern ... | 2004 | 15032855 |
| mechanisms involved in korean mistletoe lectin-induced apoptosis of cancer cells. | to investigate the anti-cancer mechanisms of korean mistletoe lectin (viscum album coloratum agglutinin, vca) using a human colon cancer cell line (colo). | 2007 | 17569116 |
| adverse effects of herbal medicines: an overview of systematic reviews. | this overview of systematic reviews (srs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (hms). five electronic databases were searched to identify all relevant srs, with 50 srs of 50 different hms meeting our inclusion criteria. most had only minor weaknesses in methods. serious adverse effects were noted only for four hms: herbae pulvis standardisatus, larrea tridentate, piper methysticum and cassia senna. the most severe adverse effects were liver o ... | 2013 | 23472485 |
| stimulation of insulin secretion by viscum album (mistletoe) leaf extract in streptozotocin-induced diabetic rats. | twenty male white rats (250-300 g) of wistar strain were randomly divided into two batches, the normoglycaemic batch and the streptozotocin-induced diabetic batch often rats each. animals in each batch were further divided into two groups of five rats per group. after an overnight fast (12 hrs), animals in each group received d-glucose load (2.0 g/kg.i.v) under pentobarbital anaesthesia, with or without the crude extract (100 mg/kg/iv). blood samples were collected intravenously at 15 min interv ... | 2008 | 18939397 |
| in vitro immunoregulatory effects of korean mistletoe lectin on functional activation of monocytic and macrophage-like cells. | korean mistletoe lectin (kml) is one of the major active components in viscum album var. (coloratum), displaying various biological effects such as anti-tumor and anti-metastatic activities. even though it has been shown to boost host immune defense mechanisms, the immunomodulatory effects of kml on specific immune responses mediated by macrophages have not been fully elucidated. therefore, in this study, we aimed to demonstrate kml's regulatory roles on macrophage-mediated immune responses. kml ... | 2007 | 17978473 |
| screening of fusion partners for high yield expression and purification of bioactive viscotoxins. | viscotoxins are small cationic proteins found in european mistletoe viscum album. they are highly toxic towards phytopathogenic fungi and cancer cells. heterologous expression of viscotoxins would broaden the spectrum of methods to be applied for better understanding of their structure and function and satisfy possible biopharmaceutical needs. here, we evaluated 13 different proteins as a fusion partners for expression in escherichia coli cells: his6 tag and his6-tagged versions of gb1, zz tag, ... | 2009 | 18983922 |
| uses of plant lectins in bioscience and biomedicine. | new research directions in the last decade have led to major developments in the uses of plant lectins in bioscience and biomedicine. major advances have been made in our understanding how lectins in the diet can act on the gastrointestinal tract and the physiological consequences of their actions, and how they can modulate body- and organ metabolism, the immune system and the gut microflora. particularly striking progress has been made in unravelling the effects, often beneficial, of both orall ... | 2008 | 17981618 |
| herb-drug interactions: an overview of systematic reviews. | the aim of this overview of systematic reviews (srs) is to evaluate critically the evidence regarding interactions between herbal medicinal products (hmps) and synthetic drugs. | 2013 | 22670731 |
| natural products of plant origin as anticancer agents. | natural products have been used as effective remedies for the treatment of various ailments. numerous plant products in the form of decoction, tincture, tablets and capsules have been clinically used for the treatment of different kinds of cancer. this review covers some of the important plants with clinically proven anticancer activity, including catharanthus roseus, podophyllum peltatum, taxus brevifolia, camptothecin acuminata, cephalotaxus harringtonia, viscum album, onchrosia elliptica, ann ... | 2001 | 12806432 |
| phylogeography and host race differentiation in the european mistletoe (viscum album l.). | mistletoes are bird dispersed, hemi-parasitic shrubs infecting a large number of woody host plants. chloroplast fragment length polymorphisms were used to study genetic differentiation among presumed host races, population genetic structure, and to elucidate the postglacial migration history of mistletoe (viscum album) across the entire natural distribution range in europe. the populations sampled belong to four closely related taxa, three of which are widely distributed and differ in their host ... | 2009 | 19434811 |
| korean mistletoe (viscum album coloratum) extract extends the lifespan of nematodes and fruit flies. | viscum album coloratum (korean mistletoe) is a semi-parasitic plant that grows on various trees and has a variety of biological functions such as immunomodulation, apoptosis, and anti-tumor activity. in this study, we investigated the effects of korean mistletoe extract (kme) on lifespan in experimental models using caenorhabditis elegans and drosophila melanogaster. supplementation of kme at 50 μg/ml extended the mean survival time by 9.61 and 19.86 % in worms and flies, respectively. the longe ... | 2014 | 24337961 |
| investigation of the proliferation, apoptosis/necrosis, and cell cycle phases in several human multiple myeloma cell lines. comparison of viscum album qufrf extract with vincristine in an in vitro model. | multiple myeloma is a haematological disorder of malignant plasma cells. interleukin-6 (il-6) is a potent growth factor for the proliferation of these cells. vincristine as a chemotherapeutic agent is used mainly in combination with other chemotherapeutic substances in the treatment of different haematological disorders. viscum album qufrf (vaqufrf) extract is an experimental drug that is not used in the treatment in tumour patients. it contains 2000 ng lectin and 10 microg viscotoxin in 10 mg e ... | 2010 | 20191244 |
| mistletoe-induced crown degradation in scots pine in a xeric environment. | increasing scots pine (pinus sylvestris l.) mortality has been recently observed in the dry inner valleys of the european alps. besides drought, infection with pine mistletoe (viscum album ssp. austriacum) seems to play an important role in the mortality dynamics of scots pines, but how mistletoes promote pine decline remains unclear. to verify whether pine mistletoe infection weakens the host via crown degradation, as observed for dwarf mistletoes, we studied the negative effects of pine mistle ... | 2010 | 20504777 |
| first fungal community analyses of endophytic ascomycetes associated with viscum album ssp. austriacum and its host pinus sylvestris. | the endophytic fungal communities in the hemi-parasitic epiphyte viscum album and in its phorophyte pinus sylvestris were compared to reveal the fungal distribution patterns in their hosts. the its nrdna of 208 multiple-isolated fungal strains was sequenced and a newly designed process was applied for assigning taxon names to the obtained sequences. furthermore, the isolates were grouped as clusters, by subjecting a sequence similarity matrix to various cluster analyses, the results of which wer ... | 2010 | 20943170 |
| mistletoe lectin transport by m-cells in follicle-associated epithelium (fae) and il-12 secretion in dendritic cells situated below fae in vitro. | a galactose- and n-acetyl-d-galactosamine-specific lectin (viscum album l. var. coloratum agglutinin, vca), which is known for its anti-tumor activity, was isolated from korean mistletoe. mistletoe preparations have been given subcutaneously because of the unstability and poor absorption in the gi tract. in this study, we investigated the effect of incubation time and glucose on the vca transport across the in vitro model of human fae (follicle-associated epithelium) by two different cell models ... | 2010 | 20945143 |
| treatment of clinically diagnosed equine sarcoid with a mistletoe extract (viscum album austriacus). | equine sarcoids (es) are common, difficult to treat, and have high recurrence rates. viscum album extracts (vae) are used in human cancer treatment. | 2010 | 21039860 |
| assessment of extracts from mistletoe (viscum album) for herb-drug interaction by inhibition and induction of cytochrome p450 activities. | three commercially available extracts from mistletoe (viscum album l.) grown on ash tree (abnobaviscum(®) fraxini 20 mg), on fir (abnobaviscum(®) abietis 20 mg), and on pine (abnobaviscum(®) pini 20 mg) were tested in vitro for their potential to interfere with the major drug metabolizing cytochromes p450 by hepatocyte viability, by inhibition of cytochromes p450 1a2, 2a6, 2b6, 2c8, 2c9, 2c19, 2d6, 2e1 and 3a4, and by the induction of cytochromes p450 1a2, 2b6, 2c9, 2e1 and 3a4. as the three ext ... | 2011 | 21538623 |
| symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins. | thioglycosides offer the advantage over o-glycosides to be resistant to hydrolysis. based on initial evidence of this recognition ability for glycosyldisulfides by screening dynamic combinatorial libraries, we have now systematically studied dithiodigalactoside on a plant toxin (viscum album agglutinin) and five human lectins (adhesion/growth-regulatory galectins with medical relevance e.g. in tumor progression and spread). inhibition assays with surface-presented neoglycoprotein and in solution ... | 2011 | 21660340 |
| korean mistletoe enriched diet enhances innate immune response in kelp grouper, epinephelus bruneus against philasterides dicentrarchi. | the present study investigated the immunostimulatory effect of korean mistletoe viscum album extract (km-e) on innate immune response in kelp grouper epinephelus bruneus against philasterides dicentrarchi. kelp grouper were divided into four groups of 25 each and fed with 0 (control), 0.5, 1.0, and 2.0% enriched diets with korean mistletoe extract (km-e). after feeding for 30 days, the fish were injected intraperitoneally (i.p.) with 100µl of p. dicentrarchi (4.2×10(7)ciliates/ml) to study the i ... | 2011 | 21807463 |
| Gene network analysis on the effect of Viscum album var. coloratum in T cells stimulated with anti-CD3/CD28 antibodies. | A galactose- and N-acetyl-D-galactosamine-specific lectin (Viscum album L. var. coloratum agglutinin, VCA), which is known for its anticancer activity, was isolated from Korean mistletoe. This study reports a microarray analysis of the effects of VCA on an activated human T cells under various times and concentrations. A total of over 3000 genes were identified whose expression levels were significantly altered against controls after treatment with VCA and anti-CD3/CD28 antibody stimulation on h ... | 2011 | 22076774 |
| effect of pine mistletoe on radial growth of crimean pine (pinus nigra) in turkey. | in this study, the influence of infection by pine mistletoe (viscum album l. subsp. austriacum (wiesb.) volmann) on the radial growth of crimean pine (pinus nigra amold) in turkey was investigated. we built local residual tree-ring-width chronologies using dendrochronogical techniques. tree ring chronologies of uninfected (control) crimean pine were used to estimate potential radial growth characteristics in the "infected" crimean pine (light, moderate and severe infection groups). in 2005, incr ... | 2011 | 22167935 |
| Case reports of sarcoma patients with optimized lectin-oriented mistletoe extract therapy. | Mistletoe (Viscum album L) extracts (ME) are widespread as immunomodulatory therapeutic agents in alternative tumor treatment. Assessing the often-controversial clinical results is rather difficult since the effects of ME on the immune system cannot be equally reproduced. Mistletoe lectins (ML) are the only mistletoe ingredients also found in vivo that are capable of having a positive effect on the immune balance of patients with tumors. Other components have only been tested in vitro, and the r ... | 2011 | 22010781 |
| Viscum album exerts anti-inflammatory effect by selectively inhibiting cytokine-induced expression of cyclooxygenase-2. | Viscum album (VA) preparations are extensively used as complementary therapy in cancer and are shown to exert anti-tumor activities which involve the cytotoxic properties, induction of apoptosis, inhibition of angiogenesis and several other immunomodulatory mechanisms. In addition to their application in cancer therapy, VA preparations have also been successfully utilized in the treatment of several inflammatory pathologies. Owing to the intricate association of inflammation and cancer and in vi ... | 2011 | 22028854 |
| a new development of triterpene acid-containing extracts from viscum album l. displays synergistic induction of apoptosis in acute lymphoblastic leukaemia. | objectives: aqueous viscum album l. extracts are widely used for anti-cancer therapies. due to their low solubility, triterpenes (which are known to act on cancers), do not occur in aqueous extracts in significant amounts. using cyclodextrins, we have found it possible to solubilize mistletoe triterpene acids and to determine their effects on acute lymphoblastic leukaemia (all) in vitro and in vivo. materials and methods: a c.b-17/scid model of pre-b all (nalm-6) was used to test efficacy and ... | 2012 | 22221251 |
| viscum album l. extract and quercetin reduce cyclophosphamide-induced cardiotoxicity, urotoxicity and genotoxicity in mice. | possible protective effects of a methanolic extract of viscum album (va) and quercetin (qe) against cyclophosphamide (cp) induced cardiotoxicity, urotoxicity and genotoxicity in mice were evaluated. mice were administered orally va (250 mg/kg/day) and qe (50 mg/kg/day) for 10 days alone or in combination with cp. after the same doses of va and qe given for 7 days, rats were intraperitoneally administered cp (40 mg/kg) on days 8 and 9 of the experiment. cardiotoxic, urotoxic and genotoxic effects ... | 2011 | 22393965 |
| holiday plants with toxic misconceptions. | several plants are used for their decorative effect during winter holidays. this review explores the toxic reputation and proposed management for exposures to several of those, namely poinsettia (euphorbia pulcherrima), english holly (ilex aquifolium), american holly (ilex opaca), bittersweet (solanum dulcamara), jerusalem cherry (solanum pseudocapsicum), american mistletoe (phoradendron serotinum), and european mistletoe (viscum album). | 2012 | 23359840 |
| improvement of dna repair in lymphocytes of breast cancer patients treated with viscum album extract (iscador). | we investigated alteration in dna repair during therapy with an immunomodulator. 14 patients with advanced breast cancer were treated parenterally with iscador, an extract of viscum album (mistletoe). as a parameter for measurement of dna repair the incorporation of (3h) thymidine into dna of unstimulated lymphocytes after ultra violet light (uv) damage was taken. the dna repair values in the patients were very low before treatment and on day 1: on average 16% of those in a healthy control popul ... | 2005 | 1782081 |
| spatial and seasonal variation in amino compounds in the xylem sap of a mistletoe (viscum album) and its hosts (populus spp. and abies alba). | in a field study, the composition and concentrations of amino compounds in the xylem sap of the mistletoe, viscum album l., and in the xylem sap of two host species, an evergreen conifer (abies alba mill.) and a deciduous broad-leaved tree (populus x euramericana), were analyzed. the xylem sap of both hosts and mistletoe contained large, but similar amounts of total organic nitrogen in low molecular weight amino compounds (tonlw). nevertheless, individual amino compounds accumulated in the xylem ... | 2004 | 15059764 |
| effects of iscador preparations on the reactivity of mouse immune system. | objectives: anticancer preparations made from plants have been an object of scientific interest for many years. it is worth noting that as many as 25% of cytostatics used in the anticancer chemotherapy are obtained from plants. one of the medical preparations which significantly influences cell metabolism is iscador. iscador preparations are used as complementary therapy in the conventional anticancer treatment. these are aqueous extracts of mistletoe (viscum album l.). one repeatedly finds that ... | 2009 | 20010495 |
| interaction of hamster submaxillary sialyl-tn and tn glycoproteins with gal, galnac and glcnac specific lectins. | hamster submaxillary glycoprotein (hsm), one of the simplest glycoproteins among mammalian salivary mucins, is composed of approximately equivalent amounts of protein, hexosamine and sialic acid. the thr and ser residues in the protein core account for more than half of all of the amino acid residues, while lys, glu, pro and ala are the major components of the remaining portion of amino acids. the carbohydrate side chains of this mucous glycoprotein have mainly the neuac-galnac-(sialyl-tn) seque ... | 1994 | 8183285 |
| a fomitopsis pinicola jeseng formulation has an antiobesity effect and protects against hepatic steatosis in mice with high-fat diet-induced obesity. | this study investigated the antiobesity effect of an extract of the fomitopsis pinicola jeseng-containing formulation (fava), which is a combination of four natural components: fomitopsis pinicola jeseng; acanthopanax senticosus; viscum album coloratum; and allium tuberosum. high-fat diet- (hfd-) fed male c57bl/6j mice were treated with fava (200 mg/kg/day) for 12 weeks to monitor the antiobesity effect and amelioration of nonalcoholic fatty liver diseases (nafld). body and white adipose tissue ... | 2016 | 27200103 |
| immune modulation using mistletoe (viscum album l.) extracts iscador. | one repeatedly finds that mistletoe (viscum album l.) extracts show immune-modulating effects. this is also true in many cases in the experimental setting. many of the experimental trials cannot, however, be transferred to the clinical situation - or only in a limited way. the aim of this work was to pursue the question of the extent to which the function of immune-competent cells can be influenced by mistletoe extracts. to do this, 3 clinical studies were carried out. results from the first two ... | 2006 | 16927532 |
| fraction a of armadillo submandibular glycoprotein and its desialylated product as sialyl-tn and tn receptors for lectins. | fraction a of the armadillo submandibular glycoprotein (asg-a) is one of the simplest glycoproteins among mammalian salivary mucins. the carbohydrate side chains of this mucous glycoprotein have one-third of the neuac alpha 2-->6galnac (sialyl-tn) sequence and two thirds of tn (galnac alpha-->ser/thr) residues. those of the desialylated product (asg-tn) are almost exclusively unsubstituted galnac residues (tn determinant). when the binding properties of these glycoproteins were tested by a preci ... | 1995 | 7875333 |
| lectinocytochemical detection of apoptotic murine leukemia l1210 cells. | various cytomorphologic and biochemical markers of apoptosis are found in different compartments (plasma membrane, cytoplasm, nucleus, and mitochondria) of target cells. although the plasma membrane is an easily accessible cellular compartment, relatively little is known about its changes during apoptosis. we investigated whether specific changes in the expression of plasma membrane glycoproteins take place during apoptosis and whether these changes could be used for a quantitative estimation of ... | 2003 | 14608636 |
| total phenolic content, antioxidant and antimicrobial activities of some medicinal plants. | crude extracts from inula aucherana, fumaria officinalis, crocus sativus, vicum album, tribulus terestris, polygonatum multiflorum, alkanna tinctoria and taraxacum officinale were screened for their in vitro antioxidant and antimicrobial properties. total phenolic content of extracts from these plants were also determined. beta-carotene bleaching assay and folin-ciocalteu reagent were used to determine total antioxidant activity and total phenols of plant extracts. antimicrobial activity was det ... | 2009 | 19168430 |
| bioactive proteins and peptides isolated from chinese medicines with pharmaceutical potential. | some protein pharmaceuticals from chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. bioactive proteins with various pharmacological properties have been successfully isolated from animals such as hirudo medicinalis (medicinal leech), eisenia fetida (earthworm), and mesobuthus martensii (chinese scorpion), and from herbal medicines derived from species such as cordyceps militaris, ganoderma, momordica cochinchinensis, viscum album, poria cocos, s ... | 2014 | 25067942 |
| an ethnobotanical study of medicinal plants used by the local people of alaşehir (manisa) in turkey. | this paper represents the first large-scale ethnobotanical study in the alaşehir and its surrounding (manisa/turkey). there are scarcely any studies for using plants. there is urgency in recording such data. this is the first ethnobotanical study in which statistical calculations about plants are done by icf (informant consensus factor) method. this study aimed to identify plants collected for medicinal purposes by the local people of alaşehir, located in the aegean region of turkey, and to docu ... | 2013 | 24126062 |
| optimization of aflp for extremely large genomes over 70 gb. | here, we present an improved amplified fragment length polymorphism (aflp) protocol using restriction enzymes (asci and sbfi) that recognize 8-base pair sequences to provide alternative optimization suitable for species with a genome size over 70 gb. this cost-effective optimization massively reduces the number of amplified fragments using only +3 selective bases per primer during selective amplification. we demonstrate the effects of the number of fragments and genome size on the appearance of ... | 2016 | 26849414 |
| galactoside-specific plant lectin, viscum album agglutinin-i induces enhanced proliferation and apoptosis of murine thymocytes in vivo. | galactoside-specific plant lectin, viscum album agglutinin-i (vaa-i) has been shown to act as a biomodulator with proinflammatory and apoptosis-inducing effects, however its cellular targets and mechanism of immunobiological action in vivo are less well understood. therefore, in the present work the short- and long-term in vivo effects of vaa-i on thymocyte subpopulations and peripheral t cells were tested using a murine (balb/c) model. cell surface cd4/cd8 staining and flow cytometry allowed us ... | 2003 | 12600741 |
| effects of aqueous soybean, mistletoe and red clover extracts on activities of adenosine deaminase and xanthine oxidase enzyme. | soybean (glycine max), mistletoe (viscum album) and red clover (trifolium pratence) have been argued to have anti-cancer effects. in the present study it was aimed to investigate possible effects of these plant extracts on the activities of dna turn-over enzymes, namely adenosine deaminase (ada) and xanthine oxidase (xo) in cancerous and non-cancerous gastric and colon tissues. for this aim, 6 cancerous and 6 non-cancerous adjacent human gastric tissues, and 7 cancerous and 7 non-cancerous adjac ... | 2014 | 25023428 |
| immunomodulation with viscum album and echinacea purpurea extracts. | extracts of viscum album (plenosol) and echinacea purpurea (echinacin) are used clinically for their non-specific action on cell-mediated immunity. in vitro we could prove that these two extracts have a stimulating effect on the production of lymphokines by lymphocytes and in the transformation test. a toxic effect on cells was produced only with very high, clinically irrelevant concentrations. clinical application of these extracts can produce a stimulation of cell-mediated immunity (one therap ... | 1987 | 3309759 |
| galactoside-specific misletoe lectin modulates dexamethasone-induced apoptosis and glucocorticoid receptor level in balb/c thymocytes. | the galactoside-specific plant lectin, viscum album agglutinin-(vaa)-i has been shown to activate the natural immune system and modulate the maturation of thymocytes in vivo. however the mechanism of this immunobiological action is not yet understood. in our previous study we demonstrated the vaa-i-induced enhancement of proliferation and selection of thymocytes which inhibited the dexamethasone (dx)-induced thymocyte depletion. in this present work we investigated the effect of 1, 4 and 21 days ... | 2013 | 12792979 |
| evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. | seven plants and a herbal mixture used for traditional treatment of diabetes were studied in streptozotocin diabetic mice. the treatments were supplied as 6.25% by weight of the diet for 9 days. consumption of diets containing bearberry (arctostaphylos uva-ursi), golden seal (hydrastis canadensis), mistletoe (viscum album) and tarragon (artemisia dracunculus) significantly reduced the hyperphagia and polydipsia associated with streptozotocin diabetes, but bayberry (cinnamomum tamala), meadowswee ... | 2006 | 2750445 |