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a filamentous flower orthologue plays a key role in leaf patterning in opium poppy.the plant-specific yabby genes were initially defined by their roles in determining abaxial/adaxial cell fate in lateral organs of eudicots, and repressing meristematic genes in differentiating tissues such as leaves. in arabidopsis thaliana filamentous flower (fil) is also required for inflorescence and floral meristem establishment and flower development in a pathway involving the floral transition and identity genes. here we describe the characterization of a fil orthologue from the basal eud ...201222816617
molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis.(s)-norcoclaurine synthase (ncs) (ec 4.2.1.78) catalyzes the condensation of 3,4-dihydroxyphenylethylamine (dopamine) and 4-hydroxyphenylacetaldehyde (4-hpaa) as the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine, sanguinarine, and berberine, in plants. a molecular clone encoding ncs was isolated from a meadow rue (thalictrum flavum ssp. glaucum) cell suspension culture cdna library. heterologous expression of the ncs cdna, truncated to remove a putativ ...200415447655
effect of unconventional oilseeds (safflower, poppy, hemp, camelina) on in vitro ruminal methane production and fermentation.dietary supplementation with oilseeds can reduce methane emission in ruminants, but only a few common seeds have been tested so far. this study tested safflower (carthamus tinctorius), poppy (papaver somniferum), hemp (cannabis sativa), and camelina (camelina sativa) seeds in vitro using coconut (cocos nucifera) oil and linseed (linum usitatissimum) as positive controls.201728188639
biological activity of plant extracts: novel analgesic drugs.the plant-derived secondary metabolites have, over the years, greatly contributed to our current understanding of the important mechanisms related to the process of pain transmission and treatment. furthermore, they have permitted us to characterise receptor types and identify endogenous ligands involved in the mechanism of nociception. in this review, we discuss the recent advances that have occurred regarding plant-derived substances in the process of development of new analgesic drugs. plants ...200115989526
naturally occurring antinociceptive substances from plants.despite the progress that has occurred in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. one of the most important analgesic drugs employed in clinical practice today continues to be the alkaloid morphine. in this review, emphasis will be given to the important contribution and the history of papaver somniferum, salix species, capsicum species and cannabis sativa in the development of new analge ...200010960893
[dependence producing substances in the practice of the insitute of forensic experts in krakow].different pieces of evidence connected with drug addiction have been used as material for studies carried out at the institute of forensic research in kraków since the end of the sixties. the number of expert's opinions concerning these questions is constantly on the increase. work done by the institute in this field has led to the creation of a list of dependence producing substances and their substitutes used by addicts, the methods of illicit production, and the ways and usable forms in which ...19979333895
[destructive effect of vapour heating and gamma-ray radiation on the germination of papaver somniferum l. and cannabis sativa l. 3]. 19685753690
[destructive effect of vapour heating and gamma-ray radiation on the germination of papaver somniferum l. and cannabis sativa l. ii]. 19685753689
[destructive effect of vapour heating and gamma-ray radiation on the germination of papaver somniferum l. and cannabis sativa l. i]. 19675629763
laūq: a sustained-release dosage form for respiratory disorders in traditional persian medicine.laūq is a pharmaceutical dosage form that had been mainly used for the treatment of various respiratory disorders in traditional persian medicine. it is important from 2 aspects: a dosage form with efficient and optimum delivery of drugs to the respiratory tract and biological effects of its ingredients. natural medicine in laūq has been demonstrated to act in respiratory disorders by their antitussive, antiallergic, anti-inflammatory, antioxidant, spasmolytic, and antibacterial activities. some ...201626008751
investigation of a substrate-specifying residue within papaver somniferum and catharanthus roseus aromatic amino acid decarboxylases.plant aromatic amino acid decarboxylases (aaads) catalyze the decarboxylation of aromatic amino acids with either benzene or indole rings. because the substrate selectivity of aaads is intimately related to their physiological functions, primary sequence data and their differentiation could provide significant physiological insights. however, due to general high sequence identity, plant aaad substrate specificities have been difficult to identify through primary sequence comparison. in this stud ...201425107664
opium poppy and madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants.alkaloids represent a large and diverse group of compounds that are related by the occurrence of a nitrogen atom within a heterocyclic backbone. unlike other types of secondary metabolites, the various structural categories of alkaloids are unrelated in terms of biosynthesis and evolution. although the biology of each group is unique, common patterns have become apparent. opium poppy (papaver somniferum), which produces several benzylisoquinoline alkaloids, and madagascar periwinkle (catharanthu ...200818476877
molecular characterization of the salutaridinol 7-o-acetyltransferase involved in morphine biosynthesis in opium poppy papaver somniferum.salutaridinol 7-o-acetyltransferase (ec ) catalyzes the conversion of the phenanthrene alkaloid salutaridinol to salutaridinol-7-o-acetate, the immediate precursor of thebaine along the morphine biosynthetic pathway. we have isolated a cdna clone that corresponds to the internal amino acid sequences of the native enzyme purified from a cell suspension culture of opium poppy papaver somniferum. the recombinant enzyme acetylated the 7-hydroxyl moiety of salutaridinol in the presence of acetyl-coa. ...200111404355
endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids.endophytes reside in different parts of the poppy plant and perform the tissue-specific functions. most leaf endophytes modulate photosynthetic efficiency, plant growth, and productivity while capsule endophytes modulate alkaloid biosynthesis. endophytes promote plant growth, provide protection from environmental stresses and are the source of important secondary metabolites. here, we established that the endophytes of opium poppy papaver somniferum l. may play a role in the modulation of plant ...201626794966
semi-continuous production of sanguinarine and dihydrosanguinarine by papaver somniferum l. cell suspension cultures treated with fungal homogenate.papaver somniferum l. (opium poppy) cells were elicited with a botrytis sp. homogenate and cultured by a semi-continuous process. elicitation induced synthesis of sanguinarine and dihydrosanguinarine. significant release of both alkaloids into the culture medium occurred. medium exchange at 2-day intervals enabled product recovery from spent medium and maintained culture viability. culture growth was not inhibited by elicitor treatment necessitating sub-culture prior to re-elicitation. re-elicit ...198824240257
medicinal plants and alzheimer's disease: integrating ethnobotanical and contemporary scientific evidence.the use of complementary medicines such as plant extracts in dementia therapy, varies according to the different cultural traditions. in orthodox western medicine, contrasting with that in china and the far east for example, pharmacological properties of traditional cognitive or memory enhancing plants have not been widely investigated in the context of current models of alzheimer's disease. an exception is ginkgo biloba in which the ginkgolides have antioxidant, neuroprotective, and cholinergic ...19989884179
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