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hla-linked genetic control of host response to mycobacterium leprae.non-random parental hla-haplotype segregation is demonstrated in siblings with leprosy. a new method is described for the statistical analysis of non-random segregation among sibships of different sizes. sibs with the same type of leprosy show a significant excess of identical hla haplotypes. this is also true for families in which only tuberculoid leprosy is found, which is by far the commonest type in the population studied. however, sibs affected with different types of leprosy share a haplot ...197663804
germicidal activity of the pigo system on mycobacterium leprae, in vitro. 197664181
the major site of guinea-pig myelin basic protein encephalitogenic in lewis rats. 197764589
[drug resistance in mycobacteria (author's transl)]. 197664637
[studies on drug resistance in mycobacteria (author's transl)]. 197664638
immunological and other laboratory studies of patients receiving short-term cimetidine therapy. 197764654
cultivation of mycobacterium leprae. 197764727
[effectiveness of the drugs of streptomycin group in experimental studies on albino mice infected with mycobacterium tuberculosis resistant to these drugs]. 197664981
[comparative study of 2 methods of decoloration of mycobacterium tuberculosis]. 197665016
[drug resistance of tubercle bacilli -- from the clinical point of view (author's transl)]. 197665494
[use of two dimensional immunoelectrophoretic method in the study of the antigenic relationships of "mycobacterium simiae" and "m. habana" (author's transl)].following the cultural, biochemical and serologic studies reported elsewhere, it was thought of interest to investigate the antigenic structure of these strains. in the present work, sonicated suspensions of the bacteria were used as antigens, together with rabbit immune serum antibodies. the optimal conditions to obtain the largest number and the sharpest lines possible, were established. in this manner, we were able to obtain on two dimensional electrophoresis patterns were obtained. using an ...197665934
antigenic relationship between the catalases of certain mycobacteria. 197666048
the effects of certain immunity systemic advuvants, pha, and human gamma globulin on the thymic cortex of mice: a light and electron microscope study.thymus of (c57bl/6 x dba/2) f1 mice was examined histologically, histochemically and ultrastructurally, seven days after intravenous injection of bcg, pertussis vaccine, lipopolysaccharide or human gamma globulin, or intraperitoneal injection of complete or incomplete freund's adjuvants or of phytohemagglutinin. only bcg induced a marked increase of the secretory activity of the thymic epithelium at all histological sites (cortex, corticomedullary junction and medullar). only with this adjuvant ...197666071
immunochemical analysis of soluble antigens of mycobacterium lepraemurium.soluble antigens obtained from purified m. lepraemurium were identified by sds polyacrylamide gel electrophoresis as three different proteins, m-w 1 x 10(4), 1 x 10(5), and 4 x 10(6), and two polysaccharide-polypeptides. three antigens were found to react with anti-m. leprae antiserum; a single antigen proved to be immunologically related to m. tuberculosis, m. similae, m. balnei and a few other mycobacteria, but not to eubacteriales and fungi, as examined by immunoelectrophoresis. in the dermal ...197666213
m. leprae versus m. scrofulaceum. 197666215
can rifampicin use be safely extended? evidence for non-emergence of resistant strains of mycobacterium tuberculosis.data on the incidence of primary resistance to rifampicin in mycobacterium tuberculosis strains have been collected from various countries. strains isolated from those countries where rifampicin is used for both tuberculous and non-tuberculous conditions (italy, argentina, brazil, and spain) did not show a higher incidence of primary resistance than did strains from other countries (france, u.k., and u.s.a.) where rifampicin use is confined to tuberculosis. it is concluded that there is no evide ...197766530
macrophage processing of antigen for induction of tumor immunity.previous studies have indicated, that, after in vitro incubation of antigen with macrophages, the "processed" antigen preferentially induces cell-mediated immunity. to investigate this phenomenon with tumor antigens, mycobacteria-stimulated macrophages were incubated with irradiated syngeneic emt6 tumor cells for varying lengths of time and injected into normal mice. on subsequent challenge with emt6, there was a significant increase in protection in mice immunized with macrophage-processed tumo ...197766987
gram stain evaluation of the quality of sputum specimens for mycobacterial culture.a group of 34 mycobacteria, consisting of 25 mycobacterium tuberculosis and nine strains of three other species, was isolated from 400 expectorated sputum specimens submitted on 148 patients from county-wide sources. eight strains (24% of the total) were isolated from specimens evaluated by gram stain to be oropharyngeal fluids. the remaining 26 strains were isolated from ungradable specimens and those primarily of lower respiratory origin. it was concluded that the random examination of sputum ...197767123
immunochemical analyses of a major antigen of mycobacterium szulgai.unheated culture filtrate of mycobacterium szulgai and a homologous goat antiserum were prepared. immunoelectrophoretic analysis demonstrated a dominant anodal antigen in the culture filtrate. by the use of diethylaminoethyl-cellulose chromatography, a fraction designated msp, which was rich in this anodal antigen, was recovered. the major antigen of msp was demonstrated to have partial identity with reference mycobacterial antigen 6, and evidence was obtained for separate shared and specific an ...197767158
[characteristics of the growth of tuberculosis mycobacteria on solid asparagine-free medium finn-2]. 197767272
[increasing the effectiveness of laboratory diagnosis of tuberculosis. ii. improvement in the method of determining the sensitivity of mycobacteria to tuberculostatic preparations]. 197767273
tuberculosis in indonesia: recent studies on detection and drug susceptibility of mycobacteria in jakarta.sputum specimens from more than 1000 indonesian tuberculosis suspects were examined by bacteriologic culture, and by bright field and fluorescence microscopy. two hundred twenty had positive mycobacterium tuberculosis cultures and of these 68% were positive by fluorescence microscopy. agreement between culture, both negative and positive, and fluorescence microscopy was 87%. sensitivity to antituberculous drugs was performed in 209 isolates. significant resistance to isoniazid, para-amino salicy ...197667646
[ziehl-negative forms of paratuberculosis mycobacteria]. 197767696
susceptibility to experimental allergic encephalomyelitis in two strains of rats and their hybrids.lewis and pvg strains of rats and their f1-hybrids were challenged with guinea-pig or bovine encephalitogenic protein (ep) in freund's complete adjuvant (fca) to produce experimental allergic encephalomyelitis (eae). the lewis and f1-rats were also challenged with guinea-pig ep in fca with a fivefold lower concentration of mycobacterium butyricum. data are presented concerning clinical signs and histological changes of eae showing an intermediate position of susceptibility to eae for the f1-hybr ...197767742
mycobacterium. 197767839
common antigen of mycobacterium leprae, m. lepraemurium, m. avium, and m. fortuitum in comparative studies using two different types of antisera.no. 21 mycobacterial antigens of mycobacterium lepraemurium, m. avium, m. fortuitum, and m. leprae were compared in crossed immunoelectrophoresis using two different antibody sources, a serum pool from lepromatous leprosy patients (lsii) and a rabbit anti-m. smegmatis antiserum. m. lepraemurium, like m. avium, was found to contain the 21 a and 21 c determinants. m. fortuitum contained in addition a new type of determinant, 21 d.m. leprae antigen no. 21 carried the a as well as the b dertminants, ...197768004
staining mycobacteria with periodic acid-carbol-pararosanilin: principle and practice of the method.mycobacteria may be acid-fast, non-acid-fast or even chromophobic in staining under different conditions. the pretreatments with oxidants including periodic acid increase effectually the acid-fastness of acid-fast bacilli. this is caused by additional free carboxyl groups resulting from non-acid-fast wax in the cell walls by demethylation with oxidants. only by prolonged periodic oxidation the aldehyde groups formed as oxidation products of 1-amino-2-hydroxy groups in the cells can be demonstrat ...197768427
cross-resistance in m. tuberculosis to kanamycin, capreomycin and viomycin.drug resistant mutants to streptomycin, kanamycin, viomycin, capreomycin, and rifampicin were isolated from four strains of mycobacterium tuberculosis. the mutants isolated from each parent were then tested for evidence of development of cross-resistance to other drugs. there was no cross-resistance between either streptomycin or rifampicin and any of the other drugs. complete cross-resistance between viomycin and capreomycin was found. cross-resistance between kanamycin and capreomycin, and kan ...197768613
experimental cancer immunotherapy: modification of tumor cells to increase immunogenicity.firmly established transplantable c3h/hej mammary carcinomas can be inhibited by host challenge with vibrio cholerae neuraminidase (vcn)-treated tumor cells. the effect is totally immunospecific, even vcn-treated tumors bearing shared mammary tumor virus (mtv) antigen cannot induce the regression. thus, vcn is capable of increasing the immunogenicity of the private, unique-unshared tumor antigens on mammary carcinomas; vcn is incapable of increasing the immunogenicity of the shared mtv-associate ...197668699
use of sepharose-conjugated bcg antibodies for the purification of tuberculin-active components.bacillus calmette-guérin (bcg) antibodies conjugated with cnbr-activated sepharose 4b led to the isolation of tuberculin-active components from the protoplasmic materials of bcg. from these results; it is concluded that most of the tuberculin-active components (sensitins) have mycobacterial antigenic properties.197768806
transfer of delayed hypersensitivity in mice to microbial antigens with dialyzable transfer factor.dialyzable lawrence-type transfer factor was prepared from the spleen cells of cf1 mice inoculated with coccidioides immitis- and candida albicans-killed vaccines and with live mycobacterium tuberculosis vaccine (bcg). these preparations were shown to transfer antigen-specific cell-mediated immunity to naive mice, as measured by the delayed skin test and footpad-swelling methods. reactivity could be demonstrated when the test antigens were given 24 h after the transfer factor, but not when they ...197768930
a modified allochrome procedure for demonstrating mycobacteria in tissue sections.a modified allochrome staining procedure is presented as being the most reliable and sensitive method for demonstrating mycobacteria in tissue sections. the technic is as follows: deparaffinize formalin fixed sections, oxidize in 10% periodic acid for 24 hours, differentiate in 1% hcl-70% ethanol, stain in weigert's iron hematoxylin nuclear stain, and counterstain in picro-methyl glue. mycobacteria stained brilliant red in contrast with the allochrome-stained background tissues, and apparently o ...197768940
regulation of antibody response in different immunoglobulin classes. iii. in vitro demonstration of "ige class-specific" suppressor functions of dnp-mycobacterium-primed t cells and the soluble factor released from these cells. 197768968
precipitation of radiolabeled antigen-antibody complexes with protein a-containing staphylococcus aureus.the feasibility of using protein a-containing staphylococcus aureus to measure antibodies in sera from several mammalian species was studied. a variety of unrelated radiolabeled antigens were tested, including components of bovine serum, dna, and bacterial and tumor-associated extracts. the use of s. aureus was found to be a reliable way to detect and measure the primary interactions between many of the antigens and antibodies tested. results were equivalent under many circumstances to those obt ...197768969
tuberculosis in tanzania: a follow-up of a national sampling survey of drug resistance and other factors.a total of 1873 patients admitted to a random sampling survey in 15 of the 61 administrative districts in tanzania in 1969 has been followed up at 1 year or later. the random sample included districts with a long-established tuberculosis service (a districts), those with a service of recent inception (b districts), and those with no specialized tuberculosis service (c districts). the main follow-up concerns 1607 patients with pulmonary tuberculosis of whom 693 had a positive culture at the initi ...197769347
cell-mediated immune response to guinea pig and bovine basic proteins of myelin in lewis and pvg rats and their hybrids.the in vitro cell-mediated immune response of rat lymph node cells (lnc) to guinea pig and bovine encephalitogenic protein (ep) has been studied with a lnc transformation test. lnc were obtained from either lewis, pvg, or f1 (lewis x pvg) rats 28 days after challenge with guinea pig or bovine ep in freund's complete adjuvant (fca) of different mycobacterium content. no differences between the strains or their hybrids in lnc response could be shown if stimulated with sensitizing ep, despite the g ...197769388
studies of sperm antigenicity. 6. in vivo and in vitro cellular reactivity in guinea pigs sensitized with fractions of guinea pig spermatozoa.normal guinea pig spermatozoa cells were homogenized by a french pressure cell. three soluble and three insoluble fractions were obtained by ultrascentrifugation and (emulsified in cfa) were used for guinea pig sensitization. the following were observed: 1) all fractions were immunogenic except one; 2) in vivo and in vitro delayed hypersensitivity was elicited in animals immunized with these fractions; 3) two distinctive histopathologic lesions were observed in the testes of sensitized animals: ...197769611
the use of immunoabsorbents for the purification of mycobacterial antigens.affinity chromatography using immunoabsorbents prepared from goat antisera has been applied to the purificaton of antigens from culture filtrates of mycobacterium tuberculosis. the optimum conditions for the preparation and use of these immunoabsorbents have been determined. urea has been studied as an eluant, and it has been found that antigen can be eluted with 4m urea at ph 9 with satisfactory yields, minimal loss of antigenicity, and minimal disruption of the immunoabsorbent.197769672
[cross-resistance of tubercle bacilli (a review) (iii) (author's transl)]. 197769737
recent advances in microbiology in leprosy.the recent advances in microbiology of leprosy are reviewed. till now the leprosy bacillus had not been cultivated in laboratory media; the recent claims of success have not been confirmed. there has been a breakthrough in the experimental transmission of leprosy to experimental animals--the white mice, the immune depressed white mice, and the nine-banded armadillo. apart from providing definite proof for the causative relationship of the bacillus discovered by hansen and the disease leprosy, th ...197770571
increased intracellular growth activity of tubercle bacilli excreted during treatment. 197770627
a possible dysfunction of melanosome transfer in leprosy: an electron-microscopic study.an e.m. study was carried out to investigate whether mycobacterium leprae occur intracellularly in epidermal melanocytes. as this could not be confirmed, the selective killing of melanocytes by cytotoxic lymphocytes could not explain the hypopigmentation in types of leprosy with a relative good immune response. there were indications that these hypopigmented lesions resulted from a disturbed transfer of melanosomes from melanocytes to keratinocytes. further research is in progress.197770920
induction and properties of dnp-specific t cells in mice sensitized to dnp-coupled mycobacterium.splenic t lymphocytes from mice sensitized to 100 microgram of dnp-coupled mycobacterium (dnp-tbc) showed in vitro proliferative response against dnp- or tnp-conjugated protein antigens. the increased uptake of 3h-thymidine induced by dnp-hsa was partially inhibited by the addition of 10(-4)m dnp-eaca. dnp-aecm-ficoll did not induce any significant proliferative responses in dnp-tbc-primed t cell population. however, priming with dnp-tbc augmented anti-dnp igg antibody response induced with dnp- ...197771649
comparison of different methods of fluorochrome staining of mycobacteria. 197772101
[isolation of live and dead mycobacteria tuberculosis by the method of differential cytochemical staining]. 197772885
[evaluation of different methods of urine processing for detection of mycobacterium tuberculosis. 2]. 197772886
the chromophobic tubercle bacilli and the problem of endogenous reactivation of tuberculosis. 197772893
rapid test for drug resistance in leprosy. 197772940
macrophage disappearance reaction in rana esculenta induced by specific antigen and rabbit lymphokines.macrophage disappearance reaction was induced by intraperitoneal injections of specific antigens in rana esculenta sensitized by bovine gamma globulin and mycobacterium bovis bcg. rabbit lymphokines derived from concanavalin a stimulated blood lymphocytes injected intraperitoneally were able to induce macrophage disappearance reaction in normal rana esculenta. this suggests that mammalian lymphokines are capable of acting in amphibia. mammalian lymphokines have not an exclusive class-specificity ...197773345
atypical mycobacteria and sterility. 197673732
[comparative experiments in animals with mycobacterium intracellular serotype davis with particular reference to pathogenicity and virulence (author's transl)]. 197774144
minimum structural requirements for encephalitogen and for adjuvant in the induction of experimental allergic encephalomyelitis. 197874289
adjuvant and immunostimulating activities (in the absence of freund's incomplete adjuvant) of chemically modified low molecular weight mycobacterial peptidoglycans.relatively low molecular weight peptidoglycan fragments extracted from two strains of mycobacterium tuberculosis var. hominis were chemically coupled with lauric acid. the fatty acid conjugates were compared with the native substances with respect to some immunopotentiating activities. in vitro, the mitogenic effect on murine spleen lymphocytes was significantly enhanced following conjugation. one of the lauric acid conjugates stimulated, upon intravenous administration in mice, the formation of ...197875834
high dose inhibition of the tryptophan peptide induced encephalitogenicity.in a previous publication (immunol. comm. 3:219, 1974) a hypothesis was proposed that the high dose inhibition of encephalitogenicity in giunea pigs seen with the tryptophan peptide, phe ser trp gly ala glu gly gln arg, and not observed with the whole myelin basic protein which contains this sequence, was the result of competitive inhibition by non-encephalitogenic fragments of the tryptophan peptide produced in vivo possibly by exopeptidases. i present data which disagrees with this hypothesis.197875835
stimulation and inhibition of macrophages prior to immunization with a hapten-carrier conjugate.delayed hypersensitivity reactions and antibody-mediated reactions to the carrier and to the hapten have been studied in animals treated with bcg or/and trypan blue before immunization with a hapten-carrier complex. the results show that it is possible to induce, with bcg, at the beginning of the response, an antigenic competition between hapten and carrier moieties of the antigen molecule. macrophages which modulate the response to the hapten-carrier complex by acting both on t cells involved i ...197775840
granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide.a synthetic muramyl dipeptide, n-acetylmuramyl-l-alanyl-d-isoglutamine, which possesses the same structure as that of a part of the peptidoglycan monomer of wax d of tubercle bacilli or bacterial cell walls was found to induce, when injected in water-in-oil emulsion, massive granulomas often accompanying abscesses in the site of injection and draining lymph nodes of guinea pigs and rats. the granulomas were composed mainly of epithelioid cells 2 weeks after injection and were indistinguishable f ...197875847
hospital distilled water as source of false-positive acid-fast smears. 197876062
an attempt at the use of immunological methods for the detection of enzymes of bcg substrains.immunological methods have been used to visualize peroxidase and dehydrogenase activities of substrains of bcg mycobacteria. immunodiffusion (id) and immunoelectrophoresis (ie) in agar gel and two-dimensional immunoelectrophoresis (2d-ie) in agarose gel were employed. in all these tests part of the id, ie, and 2d-ie preparations were stained with amido black 10b (ab 10b) to visualize the total number of precipitin lines and part were stained at the same time with histochemical methods for vizual ...197876421
the use of two-dimensional immunoelectrophoresis for the characterization of antigens of bcg substrains.the usefulness of the method of two-dimensional immunoelectrophoresis (2d-iep) in comparative studies and characterization of the antigenic spectra of various bcg substrains have been estimated. the bcg substrains used were: substrain bcg-rio de janeiro, substrain bcg-poland, form-rough (r) and substrain bcg-poland, form-smooth (s). the 2d-iep technique was found to give characteristic immunoelectrophoretic patterns of antigenic composition of the different bcg substrains. the number of precipit ...197876422
multiple forms of polyphosphate-glucose phosphotransferase in various mycobacterium strains. 197876428
requirements for induction of delay hypersensitivity in the chicken. 197876579
[improvement of the method of handling of the sputum and bronchial irrigation fluid for detection of mycobacterium tuberculosis]. 197876709
in-vitro immunological assay for diagnosis of coeliac disease. 197876821
studies on pyrazine derivatives. part x. synthesis and tuberculostatic activity of some 6-cyclamino-, 6-imidazolyl--and triazolylpyrazine-2-carboxylic acids derivatives.the 6(2'-methylpiperidine-, 2',6'-dimethylmorpholino-, imidazolyl- and triazolyl)-2-cyanopyrazines were prepared from 2-cyano-6-chloropyrazine. the -cn group was then transformed into cooh, conh2, csnh2, conhnh2, conhoh and c(noh)nh2 functions. all compounds obtained were of weak tuberculostatic activity. comp. 13 was active against isoniazide, capreomycin and ethionamide resistent strains at the concentration range of 31.2--62.5 microgram/cm3.197877010
mycobacterium chelonei iatrogenic infections.we report on two outbreaks of mycobacterium chelonei subsp. abscessus cutaneous infections, which occurred between june 1974 and april 1975 in a series of 24 patients (15 studied bacteriologically) subjected to venous stripping for varicose veins. the source of infection was the aqueous solution of merbromin used in presurgical care.197877278
mycobacterium leprae specific antibodies detected by radioimmunoassay.a radioimmunoassay was developed for demonstration of antibodies against m. leprae specific antigenic determinants. the specificity of the assay was tested with hyperimmune rabbit antisera against other mycobacteria and shown to be very high. the titre of m. leprae specific antibodies in a lepromatous serum pool was 10(5). sixty-one of sixty-two lepromatous sera, all of twelve borderline sera and twenty of forty-eight tuberculoid sera were positive in the assay, whereas all of thirty-eight cont ...197877549
[atypical mycobacterial infection due to mycobacterium fortuitum].the case is presented of a 48-year-old woman who, in association with repeated septic temperatures, developed abscesses in the region of the right shoulder and in the right ankly. histological examination from excisates revealed caseous tuberculoid granulomas. mycobacterium fortuitum was isolated from the pus of both abscesses. although the mycobacterium fortuitum was resistant to nine commonly used tuberculostatics, it was found to be sensitive to ethionamide and capreomycine. the use of these ...197877556
[protection against infection with bordetella pertussis by an oligopeptide from bordetella pertussis (author's transl)].we have isolated from bordetella pertussis an oligopeptide with characteristic amino acid composition. this peptide was applied to mice in standardized tests for pertussis immunization. in three tests with three independent isolates of peptide, a significant and dose dependent protection was observed. one microgram of peptide per mouse produces the same protective effect as 0.1 iu of pertussis vaccine. it is important to note that similar peptides can be isolated from other bacteria and other dn ...197877606
mycobacterial taxonomy: a search for discontinuities. 197877649
resistance relationships in mycobacterium smegmatis atcc 607 to phages sensitive or resistant to both chloroform and streptomycin sulphate.four of eight mycobacteriophages did not form plaques after they were exposed to chloroform. phages sensitive to chloroform did not produce plaques when plated on media containing 1000 microgram/ml of streptomycin sulphate. the same concentration of dihydrostreptomycin sulphate did not interfere with plaque formation. mutants of mycobacterium smegmatis resistant to each of the eight phages were isolated. sensitivity or resistance to chloroform and streptomycin sulphate and phage resistant bacter ...197877894
the activity of thiacetazone, thiambutosine, thiocarlide and sulphamethoxypyridazine against mycobacterium leprae in mice. 197878428
some observations of mycobacterial acid-fastness.mycobacterial acid-fastness seems most readily explainable on the basis of a "lipids barrier principle" that in the first instance hinders penetration of the water-soluble dyestuff, and in the second, hinders penetration of the bleaching acid. mycolic acids, and more especially, mycolate salts, in xylene solution complex and solubilize crystal violet, but the complex is demonstrably not stable even to weak acids. stained mycobacterial preparations are readily bleached by an acidified lipid solve ...197879318
therapeutic effect of yeast glucan in mice infected with mycobacterium leprae [proceedings]. 197779384
two methods of demonstrating leprosy bacilli in smears.two methods, the carbol fuchsin with acetic acid differentiation and the periodic acid-carbol pararosaniline, were used for demonstrating leprosy bacilli in skin smears. bacillary smears from 200 long-treated patients with tuberculoid, borderline and lepromatous leprosy were stained with periodic acid-carbol pararosaniline. there were significantly greater bi and mi determinations than with classic carbol fucsin staining. with the former stain bacilli were found in 69 of 96 skin smears in which ...197879561
[fluorescence microscopy in the diagnosis of tuberculosis (review of the literature)]. 197879675
[quantitative variant of the complement fixation test for detection of antimicrobial and anti-tissue antibodies]. 197879684
controlled clinical trial of five short-course (4-month) chemotherapy regimens in pulmonary tuberculosis. first report of 4th study. east african and british medical research councils.five 4-mo regimens of chemotherapy for tuberculosis are compared. the two regimens in which rifampicin was given throughout the 4 mo were associated with bacteriological-relapse rates of 8% in the first 6 mo after stopping chemotherapy, but the three regimens in which rifampicin was given for only the first 2 mo had relapse-rates of 24-32%. there was no evidence that the addition of pyrazinamide in the second 2 mo of chemotherapy reduced the bacteriological-relapse rate. removal of the streptomy ...197879708
pulmonary tuberculosis and bronchial carcinoma. 197879734
false-positive acid-fast smears. 197879745
in-vitro lymphoproliferative response to mycobacterium leprae of hla-d-identical siblings of lepromatous leprosy patients.lymphoproliferative responses to mycobacterium leprae and p.p.d. were measured in 23 lepromatous and borderline lepromatous leprosy patients and in 27 of their normal siblings. at the same time siblings hla-d-identical with the patients were identified by the absence of a mixed-lymphocyte reaction. the 7 siblings who were hla-identical to lepromatous patients responded as well to m. leprae as did the 20 hla-non-identical normal siblings. in contrast, 22 of the 23 lepromatous patients failed to r ...197879915
immunochemical relatedness among ribosomes of mycobacteria, nocardia and corynebacteria [proceedings]. 197880189
the correlation of bacteriophage types of mycobacterium tuberculosis with guinea-pig virulence and in vitro-indicators of virulence.among 58 isoniazid-sensitive strains of mycobacterium tuberculosis from india, burma and east africa, 23 were of phage type a, 31 of type i (intermediate), 4 of type b and none of type c. type i strains differed from type a strains in being attenuated in the guinea-pig, susceptible to h2o2, sensitive to thiophen-2-carboxylic acid hydrazide and resistant to thiacetazone and p-aminosalicylic acid; the content of strongly acidic lipids and of sulphatide lipids was low and the attenuation indicator ...197880440
mycobacteria as a possible cause of inflammatory bowel disease.mesenteric lymph-nodes from 27 patients with crohn's disease, 13 with ulcerative colitis, and 11 without inflammatory bowel disease were cultured for mycobacteria. a node from a patient with crohn's disease yielded a strain of mycobacterium kansasii. cultures from 22 other patients with crohn's disease, 7 with ulcerative colitis, and 1 control subject yielded pleomorphic organisms with the electron-microscopic appearances of cell-wall-deficient organisms. further culture and characterisation of ...197880630
search by immunofluorescence for antigens of rotavirus, pseudomonas maltophilia, and mycobacterium kansasii in crohn's disease.crohn's-disease tissue was tested by indirect immunofluorescence for antigens of rotavirus, pseudomonas maltophilia, and mycobacterium kansasii. no reactions were obtained with anti-serum to p. maltophilia and m. kansasii, and a granular fluorescence seen with rotavirus antibody was probably non-specific.197880631
further studies of the action of antithyroid drugs on mycobacterium leprae. 197880802
comparison of micrococcus, bcg and related polysaccharides in the specific and non-specific immune resistance to murine l1210 leukemia [proceedings]. 197881034
antigenicity of the phosphatidyl inositomannosides of mycobacteria. 197881174
endocarditis with acid-fast organism after porcine heart-valve replacement. 197881398
studies on the morphology of colonies of bacilli of bcg-poland substrain. i. the influence of iron on the type of bcg-poland colonies.the influence of iron concentration in sauton's medium solidified with agar on the type of colonies of bcg-poland substrains, bcg-rio de janeiro, bcg-france, bcg-denmark and bcg-japan substrains has been examined. of all the studied bcg substrains only the bcg-poland substrain formed rough (r) and smooth (s) colonies. in the investigated substrains rough colonies became smaller with the decrease of iron concentration but they retained their characteristic surface roughness. the smooth colonies w ...197881600
studies on the morphology of colonies of bacilli of bcg-poland substrain. ii. dissociation of bcg-poland substrain on löwenstein-jensen egg medium.the dissociation of colonies of the substrain bcg-poland on löwenstein-jensen medium has been studied. it had been stated previously (lipińska and rzucidło, 1974) that bcg-poland substrain undergoes a process of dissociation which manifests itself in the appearance of smooth colonies alongside typical rough colonies. attempts have been made to obtain pure culture of both colony types. pure cultures composed of smooth or rough colonies respectively were obtained. the morphology and diameter of th ...197881601
antitumor activity of mycobacterial glycolipid a1.glycolipid a1 isolated from mycobacterium bovis bcg, when dissolved in olive oil and injected together with line 10 transplantable hepatoma cells, is able to elicit a host response which results in the abrogation or retardation of tumor growth in syngeneic guinea pigs. glycolipid a1 does not have adjuvant activity for delayed type hypersensitivity, and antibodies to a1 have not been detected in the sera of guinea pigs during or after the tumor abrogation induced by a1 injection glycolipid a1 doe ...197881809
regulation of antibody response in different immunoglobulin classes. iv. properties and functions of ige class-specific" suppressor factor(s) released from dnp-mycobacterium-primed t cells.ige class-specific suppressor factors (ige-tsf) released from dnp-myc-primed t cells showed their suppressor effect in an antigen nonspecific manner, although dnp-specific stimulation was required for their induction. the suppressor activity of ige-tsf was absorbed with the alloantiserum directed to the subregions between i-a and i-e of the h-2 complex. ige-tsf from balb/c mice did not show their suppressor effect on the ige response of c57bl/6j and vice versa. the suppressor activity of ige-tsf ...197881866
disseminated atypical mycobacterial infection in hairy-cell leukaemia. 197882068
[efficacy of culture and biological studies of patients with destructive pulmonary tuberculosis undergoing chemotherapy]. 197882669
comparison of various preparations of mycobacterium leprae and other mycobacteria by lymphocyte stimulation.peripheral blood lymphocytes were stimulated in vitro with different mycobacterial antigen preparations and responses were measured as incorporation of tritiated thymidine. blood donors were 9 patients with lepromatous leprosy, 16 tuberculoid leprosy patients, and 6 healthy individuals with different degrees of exposure to leprosy. the results revealed a good correlation between the responses to m. leprae from human sources and bacilli from armadillos inoculated with human leprosy bacilli, altho ...197883309
inhibition of rubino factor as a test for detecting antigens common to leprosy bacilli. 197883310
biological studies on the degradation products of 3-[(s)-1'-phenylethylamino]propylaminobleomycin: a novel analog (pepleomycin).pepleomycin (pep), 3-[(s)-1'-phenylethylamino]propylaminobleomycin has potent activity and is less pulmonary toxic than bleomycin (blm). biological activity and toxicity of the following degradation products of pep have been studied in detail: the product of carbamoyl migration (iso), the product of decarbamylation (dc), the product of ring closure of the side chain on the pyrimidine moiety (rc), the depyruvamide product (dp) and the product of an enzymatic inactivation (da). these degradation p ...197983987
glycoproteins released by leishmania donovani: immunologic relationships with host and bacterial antigens and preliminary biochemical analysis.the antigenically active glycoproteins (aagp) released by leishmania donovani strain 3s promatigotes into growth media and by amastigotes of this strain into the tissue, e.g. blood, of infected hamsters was found to consist of 6 to 7 antigenically distinct components. the antigenic activity of these glycoproteins was resistant to freeze-thawing, protease treatment, and purification by column chromatography using sephadex g-100. this activity, however, was destroyed by na periodate and altered by ...197884074
scotochromogen infection in hairy-cell leukaemia. 197984118
mycobacteria and inflammatory bowel disease. 197984294
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