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effects of corynebacterium parvum and cortisone on the primary lewis tumour and its metastases.the effects of corynebacterium parvum and cortisone acetate (ca) on the primary lewis lung carcinoma and its pulmonary metastases were investigated. c. parvum given iv either on the same day or 7 days after tumour inoculation, reduced primary tumour growth, while 2.5 mg ca (high-dose) given sc 4 and 11 days after tumour, alone or in combination with c. parvum, administered on day 0, reduced primary tumour growth to the same extent as c. pravum alone. high-dose ca given on days 2 and 6 had no eff ...1978669856
effect of corynebacterium parvum on the proliferative rate of granulocyte-macrophage progenitor cells and the toxicity of chemotherapy.we have studied the interaction of corynebacterium parvum and a variety of cell cycle-specific and cell cycle-nonspecific chemotherapeutic agents on granulocyte-macrophage progenitor cells [colony-forming units culture (cfu-c)] in c57bl/6 mice. in vitro tritiated thymidine suicide studies showed an increased rate of proliferation of bone marrow cfu-c 24 hr after c. parvum injection. in vivo toxicity of cell cycle-specific agents but not of cell cycle-nonspecific agents for bone marrow cfu-c was ...1978679169
comparison of the inhibition of tumor growth following local or systemic administration of corynebacterium parvum or other immunostimulating agents with or without cyclophosphamide. 1978679170
induction of interferon in mice injected with heat-killed corynebacterium anaerobium. 1978671815
experimental induction of caseous lymphadenitis in sheep by intralymphatic inoculation of corynebacterium ovis.lesions histologically similar to those of natural caseous lymphadenitis developed in sheep popliteal lymph nodes following injection of viable corynebacterium ovis cells into afferent lymphatic ducts. histopathological examination of affected lymph nodes suggested that exotoxin might be involved in the establishment, progressive development and persistence of caseous lymphadenitis lesions through localised cytotoxicity.1978674838
coagulation and fibrinolysis during the infusion of corynebacterium parvum in man. 1978678428
anaerobic bacteremia as observed in a children's hospital. clinically this may signify true anaerobic sepsis.to ascertain the significance of anaerobic bacteremia in a children's hospital, the records of all patients whose blood cultures grew anaerobes during a 24-month period were reviewed. anaerobes were isolated from 144 out of 1,126 blood cultures yielding bacteria. anaerobic diphtheroid grew in 122 out of 143 anaerobic cultures, but only 4 out of 122 were isolated from patients with anaerobic sepsis. nine per cent of the total episodes of anaerobic bacteremia occurred in 13 children who met out cr ...1978679583
cytotoxic activity of human blood monocytes against cultured breast cancer cells.cytotoxic activity of blood monocytes from 19 healthy individuals was examined in vitro against the cultured floating cells of human breast cancer origin. target tumor cells inoculated on monocyte cultures and maintained for 5 days were reduced in number, compared with the control cultues of tumor cells alone. increased cytotoxicity of the monocytes was noted after in vitro activation by heat-killed corynebacterium liquefaciens (propionibacterium acnes). c. liquefaciens of the same dose as used ...1978680464
the isolation and characters of l-forms and reversions of bacillus licheniformis var. endoparasiticus (benedek) associated with the erythrocytes of clinically normal persons.thirty-eight strains of the gram-positive bacterium identified as bacillus licheniformis var. endoparasiticus (benedek), referred to as ble, were isolated in various stages of reversion form the l-forms, from 28 out of 100 samples of whole blood or erythrocytes from normal healthy subjects, after prolonged incubation. similar results were obtained from 100 samples from hospital patients with conditions not usually associated with blood infection. ble was isolated from only one of 125 samples of ...1978682179
[combination of chemotherapy and immunotherapy in the treatment of carcinoma of the mammary gland in mice (author's transl)]. 1978682831
[preliminary results of polychemiotherapy and immunostimulant treatment with corynebacterium parvum in tumors of the breast in the postoperative phase and advanced phase].difficulties still encountered in the coordinated interdisciplinary management of solid tumours in hospitals are discussed. preliminary results obtained with a polychemical and immunostimulating protocol based on corynebacterium parvum (introduced in 1973) in breast tumours immediately after surgery and in the advanced stage are presented. two out of eight subjects with advanced forms died. partial regression or a steady state were noted in the remainder. no locoregional recurrences or metastase ...1978683548
anaerobic microflora of the vagina in children.vaginal cultures from 25 healthy girls from two months to 15 years of age were examined for aerobic, facultatively anaerobic, and obligately anaerobic bacteria. an average of 8.7 species (3.7 aerobic and facultatively anaerobic species; 5.3 obligately anaerobic species) were isolated from these cultures. staphylococcus epidermidis (21), diphtheroids (20), bacteroides (19), peptococci (19), peptostreptococci (14), and bacteroides melaninogenicus (14) were most prevalent organisms.1978686083
interferon production and lymphocyte stimulation in human leucocyte cultures stimulated by corynebacterium parvum.killed c. parvum organisms stimulated a lymphoproliferative response in human peripheral leucocyte cultures of both adult and cord blood origin. they also induced high titres of interferon in cultures of adult leucocytes, but there was no correlation between the degree of lymphocyte stimulation and of interferon production. a considerable variability between donors was seen in both assays. the amount of interferon produced in c. parvum-stimulated cultures was considerably higher than that stimul ...1978688696
pyogenic infections. 1978692161
fungal infections. 1978692164
influence of iron on corynebacterium renale-induced pyelonephritis in a rat experimental model.growth of corynebacterium renale in vitro on low-iron medium (1.34 micron) was only slightly less than that on high-iron media (7.16 and 9.85 micron). however, studies on c. renale-induced pyelonephritis using the rat as an experimental model revealed that c. renale cultivated in high-iron media was capable of producing pyelonephritis, but when grown on low-iron medium, these bacteria were noninfective. this apparent avirulence of the bacteria cultivated on low levels of iron could be reversed b ...1978689735
a preliminary study of the serotypes of corynebacterium genitalium by means of the complement-fixation test. 1978689838
preliminary observations on the use of corynebacterium parvum in patients with primary intracranial tumors: effect on intracranial pressure.it has been observed that patients with metastatic brain lesions developed neurologic symptoms when given corynebacterium parvum. to obtain more information in patients with intracranial mass lesions, intracranial pressures (icp) were measured or observed in six patients undergoing c. parvum therapy. all patients except two (one previously shunted, one recently operated) demonstrated a profound increase in icp. it is presumed that either edema is formed within brain and tumor tissue (inasmuch as ...1978692136
immunoproliferative alterations in lymphoid tissues and liver in mice stimulated with corynebacterium parvum.morphological alterations in the spleen, liver, lymph nodes, thymus, bone marrow and blood were studied in dba and balb/c mice treated with corynebacterium parvum. the spleen lymph nodes and liver increased in size and weight, whereas thymus showed decrease in weight compared to the control group. a marked, early proliferation of monocytes in the bone marrow preceded infiltrations by macrophages in lymph nodes, spleen and liver. these infiltrations were closely related to the vascular structures ...1978696333
[some amino acid stimulators and inhibitors of growth of corynebacterium sepedonicum (spieck, and kott., skapt. and burkh.) in synthetic media]. 1978709437
isolation of lipopolysaccharides and the effect of polymyxin b on the outer membrane of corynebacterium autotrophicum.lipopolysaccharides (lps) from corynebacterium autotrophicum were isolated and analyzed. autotrophically grown cells contained 2--5 mg of partly purified lps per g dry weight of lyophilized cells. serological cross reaction with lipid a antigen of salmonella minnesota confirmed the presence of lps in c. autotrophicum. electron microscopy of negatively stained polymyxin b-treated cells showed formation of blebs on the outer membrane indicating an interaction of polymyxin b specifically with lps. ...1978697503
porcine arthritis and meat hygiene in south africa.the incidence, economic implications, aetiology and possible public health significance or porcine arthritis in south african slaughter pigs is discussed. an investigation into the aetiology and pathology of porcine arthritis as found at a south african abbattoir revealed that erysipelothrix rhusiopathiae was present in 48% of the affected joints and streptococcus spp., corynebacterium spp. and staphylococcus spp. in 20%, 4% and 2% respectively. the joints showed various degress of subacute to c ...1978702509
corynebacterium parvum-induced peritoneal exudate cells with rapid cytolytic activity against tumour cells are non-phagocytic cells with characteristics of natural killer cells.peritoneal exudate cells taken from mice 3 days after intraperitoneal treatment with corynebacterium parvum (cp) have been shown to kill specifically certain tumour targets in vitro. we have analysed in detail such cp-induced cytotoxic cells as to their cellular characteristics, considering the fact that size and charge characteristics of cellular subgroups are useful markers in describing their representative characteristics. we could thus show that the cytolytic cell could not be classified as ...1978705263
a preliminary study of intralesional, intralymph node, intravenous and intraperitoneal corynebacterium parvum treatments in patients with advanced cancer.twenty-one patients with squamous cell carcinoma of oral cavity and/or cervical lymph node and four patients with soft tissue sarcomas were given intralesional (2-4 mg/m2) and intralymph node (2-4 mg/m2) c. parvum injections followed by 5 intravenous (2-4 mg/m2) c. parvum treatments and conventional therapies. seven patients with stage iii ovarian carcinomas were given intraperitoneal (2-4 mg/m2) c. parvum injections followed by conventional therapies. the local and systemic effects of the c. pa ...1978709538
portal and systemic bacteraemia and endotoxaemia in liver disease.using a percutaneous transhepatic technique, blood was obtained from the portal veins of 30 patients with various hepatic disorders and examined for the presence of bacteria and endotoxin. simultaneous samples also were drawn from hepatic and peripheral veins. in three cases, portal vein cultures grew diphtheroids, which were of doubtful significance, while all hepatic and peripheral cultures were sterile. endotoxin was detected in seven portal vein samples; in none of these patients were the he ...1978710964
combined radiotherapy and corynebacterium parvum treatment of rat tumors with different immunogenicity. 1978711536
lysozyme levels and macrophage content of tumor tissue in c3h mice bearing fibrosarcoma transplants treated by radiation and corynebacterium parvum. 1978711553
[bacterial isolates from patients with chronic otitis media and changes in their antimicrobial susceptibility with assay inoculum size (author's transl)]. 1978712468
toxicity manifestations following intravenous corynebacterium parvum administration to patients with ovarian and cervical carcinoma.manifestations of clinical toxicity were evaluated following 341 courses of intravenous corynebacterium parvum adjuvant immunotherapy in patients with ovarian and cervical carcinoma. most patients exhibited symptoms of minor toxicity, which decreased in intensity as subsequent courses of therapy were administered. temperature elevations to 38.5 degrees c. were the most objectively measured signs of toxicity but temperature elevations greater than 38.5 degrees c. occurred following only 20.5 per ...1978717456
immune prophylaxis of experimental cancer by corynebacterium parvum.fractionated administration of c.p. i.v. in mice at risk from sarcomas after injection of 0.2 mg mca leads to a significant prolongation of the period of latency under certain circumstances. experimental groups which have received the immune stimulator for 6 weeks immediately after the cancerogenic factor show the best results. after tumour manifestation there is no perceptible preventive effect of c.p.1978720440
destruction of regional lymph node metastases of rat mammary adenocarcinoma 13762a by treatment with corynebacterium parvum.intratumoral administration of corynebacterium parvum to 13762a tumor-bearing rats on day 7 of tumor growth, followed by primary tumor excision on day 20, regularly cured about 40% of the animals and significantly prolonged survival in the remainder. rats treated by surgery alone on either day 7 or day 20 died with metastases to axillary lymph nodes and lungs. tumor was established in axillary lymph nodes by day 7. therefore, intratumoral injection of c. parvum on day 7 destroyed metastases alre ...1978719637
positive 67ga-citrate scans in patients receiving corynebacterium parvum.gallium-67 citrate imaging for the staging of lymphomas was performed in three patients receiving corynebacterium parvum (c. parvum) immunotherapy. unexpected uptake at the site of c. parvum injections was identified and although the mechanism of localization is not determined by this study, similarities between c. parvum's known actions and the postulated mechanism of 67ga-citrate localization are compared.1978719980
further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide--viii. 1978721660
bacterial and fungal flora of the sockets. 1978721246
comparative effects of corynebacterium parvum, brucella abortus extract, bacillus calmette-guérin, glucan, levamisole, and tilorone with or without cyclophosphamide on tumor growth, macrophage production, and macrophage cytotoxicity in a murine mammary tumor model.in this laboratory, it has been repeatedly demonstrated (using a murine mammary tumor model) that the combination of cyclophosphamide (cy) and corynebacterium parvum (cp) is more effective than either agent alone in the control of tumor growth. this paper presents information obtained in our model comparing findings on the effects of cp with a brucella abortus extract (bru-pel; bp) and glucan (gl) on tumor growth. in addition, the influence of those agents as well as bacillus calmette-guérin, ti ...1978728912
effect of glucan and other adjuvants on the clearance of radiolabeled tumor cells from mouse lungs.the iv injection of two forms of glucan (diluzio and yamamura), corynebacterium parvum, or bacillus calmette-guérin (bcg) caused a significant increase in the rate and extent of clearance of subsequently injected radiolabeled t1699 carcinoma cells from the lungs of syngeneic dba2 mice. dose-response curves were obtained for each agent, the relative rates of clearance of radiolabeled cells were established, and preliminary sequential comparative studies were undertaken. the optimum dose for c. pa ...1978728905
microbial production of essential amino acid with corynebacterium glutamicum mutants.amino acids produced by microbial process are generally l-forms. the stereospecificity of the amino acids produced by fermentation makes the process advantageous compared with synthetic process. microorganisms employed in microbial process for amino acid production are divided into 4 classes; wild-type strain, auxotrophic mutant, regulatory mutant and auxotrophic regulatory mutant. using such mutants of corynebacterium glutamicum, all the essential amino acids but l-methionine are now being prod ...1978727028
reduced spontaneous antitumour resistance of the elderly rat is restored by corynebacterium parvum. 1978728345
studies on putative adult worm-derived vaccines and adjuvants for protection against schistosoma mansoni infection in mice.intraperitoneal transfer of viable adult worms of schistosoma mansoni did not confer protection against a challenge infection to recipient mice. antigens of schistosome origin were evaluated for their ability, with and without concomitantly administered nonspecific adjuvants, to stimulate protective immunity against s. mansoni. freshly perfused ground worms or a putative membrane antigen extracted with 0.5 m kc1 from adult worms, when injected together with corynebacterium parvum (or in a single ...1978739318
immunological relatedness of ribosomes from mycobacteria, nocardiae and corynebacteria, and microorganisms in leprosy lesions.serological relatedness of ribosomes from microorganisms of the mycobacterium, nocardia, and corynebacterium genera has been analyzed by the microplate immunodiffusion technique. mycobacterium and nocardia proved homogeneous and closely related taxa, whereas corynebacterium was found to be a heterogeneous phylum connected by remote links to the others. the taxonomic position of "diphtheroid microorganisms" (non-acid-fast, gram-positive bacteria morphologically similar to corynebactria), which we ...1978730371
purification and properties of a bacteriocin-like substance (acnecin) of oral propionibacterium acnes.propionibacterium acnes cn-8, isolated from human dental plaque, was grown in a liquid medium, and its bacteriocin-like substance (acnecin) was extracted from the cells by ultrasonic treatment. acnecin was purified to a homogeneous state with recovery of 47%. specific activity increased 72-fold in comparison with the crude extract. the properties of acnecin were as follows. (i) acnecin may consist of five subunits with a molecular weight of about 12,000. (ii) its isoelectric point was 5.5. (iii) ...1978742876
testicular pathology of merino rams.the scrotal contents of 2,281 merino rams of wide age range examined at 3 abattoirs in perth, western australia, showed a 40% prevalence of rams with 1 or more gross lesions. the percentage prevalence of gross lesions found on autopsy were: adhesions 21, testicular atrophy/hypoplasia 14, testicular calcification 13, congenital cyst of the epididymis 6, cryptorchidism 4, chronic epididymitis/scrotal abscesses 2, varicocoele 2, testicular aplasia less than 1, seminoma less than 1. the prevalence o ...1978743044
[formation of b12 auxotrophs among spontaneous streptomycin-resistant mutants of corynebacterium glutamicum].the spontaneous mutation to streptomycin-resistance (strr) was selective for isolating the definite type of auxotrophs (b12) of grampositive bacteria, corynebacterium glutamicum atcc 13032. a correlation between the resistance to the antibiotic and the requirement of vitamin b12 of this culture is suggested.1978744479
production of surface-active lipids by corynebacterium lepus.corynebacterium lepus was grown in 20-liter batch fermentations with kerosene as the sole carbon source. critical micelle concentration measurements indicated the production of appreciable quantities of biosurfactants. this surface activity of the culture medium was due to lipids, which were extracted and identified. samples of c. lepus whole broth were taken during a fermentation and monitored for surface tension, amount of surfactant present, and lipid content. the changes in the surfactant me ...1979760639
effects of dose and schedule of immune stimulant on efficacy of combination corynebacterium parvum-cyclophosphamide treatment for a murine mammary adenocarcinoma.certain variables which might influence the outcome of combining cytotoxic drug and immune stimulant therapy were studied to optimize the effectiveness of corynebacterium parvum combined with cyclophosphamide (cy) as treatment for a murine mammary adenocarcinoma (cad2). optimal effects of combined c. parvum-cy treatment in the cad2 system were obtained when 443 to 1400 microgram of this immune stimulant per mouse were injected 2 to 3 days after cy chemotherapy and when combination treatment was ...1979761179
a bladder tumor model response to immunotherapy.the author presented results of bcg and corynebacterium parvum treatment of the transplantable mouse fanft bladder tumor carried in the host's leg. a comparison was made of the results of treatment with bcg alone and c. parvum alone or either used in conjunction with cytoxan upon effectiveness in increasing animal survival and retarding tumor growth.1978748789
local corynebacterium parvum therapy in early breast cancer: a pilot study. 1978750126
effect of corynebacterium parvum on hemopoietic stem-cell kinetics.the intravenous administration of 548 microgram of killed corynebacterium parvum (c. parvum) into c57bl mice leads to a significant decrease in the number of bone-marrow colony-forming-units in spleen (cfus) as early as 12 h after the injection of the bacterium. this decrease persisted in varying degrees for 3 weeks. after an initial fall at 24 h, the splenic cfus exhibited a rapid expansion and reached values 10 times higher than the control range on the ninth day. a significant rise in the num ...1979759377
meso-alpha,epsilon-diaminopimelate d-dehydrogenase: distribution and the reaction product.a high activity of meso-alpha-epsilon-diaminopimelate dehydrogenase was found in extracts of bacillus sphaericus, brevibacterium sp., corynebacterium glutamicum, and proteus vulgaris among bacteria tested. b. sphaericus ifo 3525, in which the enzyme is most abundant, was chosen to study the enzyme reaction. the enzyme was not induced by the addition of meso-alpha-epsilon-diaminopimelate to the growth medium. the reaction product was isolated and identified as alpha-amino-epsilon-ketopimelate by ...1979762012
tripeptide hydroxamate from corynebacterium kutscheri.a tripeptide hydroxamate was isolated from cultures of corynebacterium kutscheri grown on an iron-limiting medium. the metabolite was characterized by spectral measurements and by chemical degradation as l-alpha-aspartyl-l-alpha-n-hydroxy-aspartyl-d-cycloserine.1979762013
[isolation of bacteria assimilating ethanol from natural and industrial substrates]. 1975765694
proceedings: the effect of bacille calmette-guérin (bcg) and corynebacterium parvum on the development of spontaneous mouse mammary carcinoma. 1976766891
[condition of microflora of the nasopharynx in immunization with live influenza vaccine for oral administration].the authors present data concerning the state of the microflora of the nasopharynx in the immunization of adults and schoolchildren with the living influenza vaccine for oral administration. during the vaccinal process there occurred qualitative changes in the microbial pattern of the nasopharynx and a reduction in the level of the salivary lysozyme. the most pronounced changes were seen after the first vaccination, when the seeding efficiency of the pathogenic staphylococcus the e. coli and the ...1975766528
bacillus calmette-guérin immunotherapy in combination with dtic (nsc-45388) for the treatment of malignant melanoma.combination studies of immunotherapy and dtic chemotherapy for patients with malignant melanoma are described. at our institute the combination of bacillus calmette-guérin (bcg) with dtic, or dtic plus methyl-ccnu, has resulted in augmentation of remissions in areas regional to bcg immunization, prolongation of chemotherapy-induced remissions, and significant prolongation of survival compared to the use of dtic chemotherapy without immunotherapy. data from other centers have shown that augmentat ...1976769970
the role of macrophages in the adjuvant effect on antibody production of corynebacterium parvum.spleen cells from mice pre-treated with c. parvum gave an enhanced in vitro antibody response to srbc, but not to dnp-pol. this enhancing activity was associated with the adherent, but not the non-adherent spleen cell population and was found to be radioresistant. it is concluded that macrophages are directly involved in the adjuvant effect of c. parvum and the possible mechanisms of action are discussed.1976770033
phase i study of corynebacterium parvum in patients with solid tumors.nineteen patients with various solid tumors were treated with corynebacterium parvum for 10 consecutive days at doses ranging from 0.5 to 6 mg/m2. major toxic effects included rigors and cyanosis, hypertension, headache, nausea, and vomiting. toxicity was maximal during the first 3 days of treatment and decreased or even disappeared when, on subsequent days, increasing doses of the vaccine were given. objective tumor regressions were observed in four patients.1975769953
studies on the occurrence of peptococcus indolicus and corynebacterium pyogenes in apparently healthy cattle. 1976773138
"xenogeneic resistance" to rat bone marrow transplantation. iii. maturation age, and abrogation with cyclophosphamide, corynebacterium parvum and fractionated irradiation.lethally irradiated c57 bl/6 mice and (c57 x a) f1 hybrids fail to accept doses of rat bone marrow cells (5 x 10(6)) which give confluent splenic repopulation in "non-resistant" strains of mice. this phenomenon has been termed "xenogeneic resistance" (xr). xr in (c57 x a) f1 mice can be overridden by a very large inoculum of rat bone marrow (26 x 10(6) cells). xr is not manifest in mice of a resistant strain at ages of 18 days or younger, but is manifest at ages of 22 days and older. xr can be a ...1976773442
the bacterial flora of the female rat genital tract.a study of the genital microflora in virgin female rats of reproductive age has demonstrated that alpha and nonhemolytic streptococci, pasteurella pneumotropica, diphtheroid bacilli, staphylococcus epidermidis, and proteus mirabilis are the predominant genital organisms. the ph of the rat vagina was demonstrated to be near neutrality. it is suggested that the higher ph in the rat vagina as compared to the human vagina may account for some of the differences between human and rat genital microflo ...1976768992
nonspecific immunotherapy by corynebacterium parvum: phase i toxicity study in 12 patients with advanced cancer.corynebacterium parvum, a non-specific immunopotentiator, was administered intravenously to 12 patients with advanced cancer at 2, 3, and 4 mg/m2 dose levels in combination with radiation therapy. one dose of c. parvum was given every 7 days for a total of 4 doses in 21 days. symptoms and signs developed by these patients for a period of 3 to 6 hours during and shortly after the i.v. infusion of the first dose of c. parvum were moderately severe in nine patients and mild in three patients. for t ...1976769937
[human diseases caused by corynebacterium pyogenes varians hominis]. 1976772516
observations on experimental mastitis in mice with reference to summer mastitis in cattle. 1976773972
assessment of wound contamination during surgery: a preliminary report comparing vertical laminar flow and conventional theatre systems.as part of an on-going trial comparing wound infection in "ultra-clean" air and conventional theatres, wound contamination is assessed by a simple wash-out technique. the importance of wound contamination in relation to subsequent wound infection is emphasized. the wash-out technique used is simple to perform and minimizes the risk of contamination. the preliminary results confirm that cleaner air does result in less contaminated wounds.1976776326
prodiginine (prodigiosin-like) pigments from streptomyces and other aerobic actinomycetes.about 95 microorganisms, mainly streptomycetes, were examined for prodiginine pigments. the test methods, including some media for stimulating pigment production, are given. all nine strains which produced prodiginine pigments were characterized and the pigments identified. the results were used to propose structures for five prodigiosin-like pigments from actinomycetes reported in the literature between 1947 and 1964. streptoverticillium sp. 26-1 furnished good yields of butylcycloheptylprodigi ...1976776374
enhancement of tissue invasion in murine aspergillosis by systemic administration of suspensions of killed corynebacterium parvum.the effect of killed corynebacterium parvum vaccine on the course of murine aspergillosis is described. a grid-counting technique was employed to quantitate tissue invasion by aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed c. parvum vaccine. simultaneous treatment of mice with c. parvum and a. nidulans significantly increased the mortality rate, in contrast to treatment of mice with c. parvum prior to or follo ...1976779492
antibacterial activity of stimulated guinea pig peritoneal exudate cell culture supernates. 1976779970
comparative isolation of vaginal yeasts on selective and nonselective media.the isolation of vaginal yeasts was compared on a selective medium, phosphomolybdic acid agar, and on starch agar, a nonselective differential medium used primarily to isolate corynebacterium vaginale. the majority of the candida albicans strains were isolated on starch agar, but the selective medium was required for isolating all yeasts from the greatest number specimens.1976780374
the effect of hydrocortisone on the immune response of mice treated with corynebacterium parvum. 1976776469
[clinical studies of an experimental suppurative surgical infection in cattle caused by cornynebacterium pyogenes].studied were clinically and paraclinically six cattle manifesting an experimental suppurative surgery infection caused by cornebacterium pyogenes, strain 1056. it was established that the infection assumes the course of septicaemia with metastases in the viscera, causing severe disturbances in the general condition and leading to death in most cases. found were also anemia, leukopenia, that alternated with leukocytosis presenting nuclear shift to left, changes in the erythrocyte sedimentation ra ...1976785801
[bacterial flora of the conjunctival sac of the horse].the aa. report the results of taxonomic research conducted on the conjunctival sac of 59 horses for identification of the present bacterial flora. in the controlled animals, it was observed, at the level of the considered niche, a community constituted of normal bacterial populations, but not autochtonous in the significance they attributed from dubos et al., relative to the characterization of the indigenous microbiota of the intestine. the isolated normal bacterial flora seems to be constitute ...1976788654
immunotherapy in the management of myelogenous leukemia.now that it has been clearly established that tumor-associated antigens exist in acute leukemia in man, as in animals, the possibility of stimulating the patient's immune system to react against them arises. in animal experiments the most effective method of influencing the progress of leukemia after the implantation of living malignant cells has been a combination of nonspecific stimulation of the reticuloendothelial system, with agents such as bcg or corynebacterium parvum, either with chemoth ...1976793553
a clinical double-blind trial of topical miconazole and clotrimazole against superficial fungal infections and erythrasma. 1976788971
design of phase-i trials of immunopotentiators for cancer therapy: levamisole and corynebacterium parvum. 1976793480
microbiology of the foot. 1976791072
relationship between intradermal tumor suppression and tumor immunity.intradermal (id) injection of three tumor-immune stimulant mixtures (lstra-bcg, 13762a-bcg, cad2-corynebacterium parvum) was superior to the sc site for suppression of tumor growth: suppression of lstra-bcg mixtures was even less efficient after an ip or iv injectiouppression at all four sites. in the lstra-bcg model, the id site was not uniquely favorable for either the afferent or efferent limb of the immune response; the other sites produced equally effectiveimmunization or rejection of tumor ...1976794505
[studies of cell arrangement in bacterial colonies by scanning electron microscopy--application of co2 critical-point drying technic]. 1976794527
antibody response to and immunity induced by corynebacterium pyogenes vaccine.a procedure is described for producing a high quality c. pyogenes vaccine. a satisfactory antibody response was obtained by administering 3 subcutaneous injections of vaccine at 10-day intervals, using doses of 2,0 ml for rabbits, 5,0 ml for sheep and 10,0 ml for cattle. the titres resulting from this procedure compared favourably with those obtained from following the more intensive schedule and higher doses of vaccine recommended by the british veterinary codex. the antibody response was at it ...1976796776
stopcock contamination in an icu. 1975803350
[action of decamethoxin on diphtherial exotoxin].the results of the study of the detoxicating effect of decamethoxin on diphtheria toxin are presented. it was noted that decamethoxin in subbacteriostatic concentrations inhibited the process of the toxin production in corynebacteria diphtheriae. the detoxicating effect of the drug was clearly evident when used in a concentration of 10gamma/ml at a 2-hour exposure. decamethoxin in a dose of 0.1 gamma/ml neutralized the effect of the diphtheria toxin on contact for 24 hours.1975804292
biologically active components from mycobacterial cell walls. iii. production of experimental allergic encephalomyelitis in guinea-pigs.the efficacy of various fractions of mycobacterial cell walls in producing experimental ahlergic encephalomyelitis (eae) has been evaluated. bcg (bacillus-calmette-buérin) cell walls were effective in producing eae in all animals at dose levels as low as 40 mug. study of subfractions of these cell walls revealed the following: (1) wax d was active, but required larger doses than bcg cell walls; (2) the chloroform-methanol-soluble (cms) portion of wax d and p3 (a mycolic acid-trehalose ester cont ...1975804436
in vivo cortisone sensitivity of nonspecific antitumor activity of corynebacterium parvum-activated mouse peritoneal macrophages.the nonspecific antitumor activity of corynebacterium parvum-activated mouse peritoneal macrophages in vitro was inhibited by their prior treatment with cortisone acetate in vivo. inhibition was marked (60 percent) 24 hours after cortisone injection and was still significant at 7 days, but antitumor activity was completely recovered by 9 days. this transient inhibition was sufficient to abolish the non-specific protection afforded by c. parvum in an in vivo pretreatment model.1975804567
new method for the large-scale preparation of diphtheria toxoid: purification of toxin.diphtheria toxin of high purity was prepared in batch cultures of 1 to 40 liters by procedures capable of processing 200-liter batches without modification. the procedure incorporates preliminary purification of the growth medium and, after deep fermentation or sulfate culture of corynebacterium diphtheriae, both concentration and partial purification of the toxin by membrane ultrafiltration. final purification is achieved by sephadex g-100 gel filtration. purities of 2,000 to 2,500 flocculation ...1975804848
effect of polychlorinated biphenyl formulations on the growth of estuarine bacteria.polychlorinated biphenyl formulations inhibited the growth of certain estuarine bacteria. the sensitive strains, although exhibiting some similar physiological characteristics, contained both gram-positive and gram-negative bacteria.1975803286
letter: clinical diphtheria from nontoxigenic corynebacterium? 1975804026
the role of cutaneous diphtheria infections in a diphtheria epidemic.twenty-four people with diptheria and 48 carriers were found in an isolated, circumscribed, rural area during a one-month period. four patients had cutaneous lesions, which were similar to those of typical impetigo, form which corynebacterium diptheriae was isolated. these cases constituted an epidemiologic focus from which the other cases were infected. ten of 52 classroom contacts of two patients with skin infections harbored c. diphtheriae in the pharynx, while only eight of 132 classroom con ...1975805182
interaction of toxin of corynebacterium diphtheriae with phagocytes from susceptible and resistant species.the interaction of the toxin of corynebacterium diphtheriae with leukocytes from sensitive and resistant animal species was examined by determining the ability of toxin to inhibit protein synthesis by several types of phagocytic cell. small amounts of toxin (25 minimal lethal doses) impaired protein synthesis in both polymorphonuclear leukocytes and mononuclear cells from humans and guinea pigs, whereas large amounts (2,000 minimal lethal doses) were required for minimal inhibition of mouse phag ...1975804024
letter: diphtheria carriers. 1975806244
effects of corynebacterium granulosum on weight and histology of lymphoid organs, response to mitogens, skin allografts, and a syngeneic fibrosarcoma in mice.we studied the effect of single and multiple injections of corynebacterium granulosum on weight and histology of lymph nodes and spleen, on peripheral white blood cell count, response of peripheral blood lymphocytes, lymph node, and spleen cells to phytohemagglutinin and pokeweed mitogen, survival of skin allografts, and lung metastases of a syngeneic fibrosarcoma in c3hf/bu mice. corynebacterium parvum was used in some studies on antitumor activity. the weight of lymph nodes and spleen was mark ...1975807323
[production of epsilon-n-acetyl-l-lysine by a corynebacterium mutant over-producing lysine]. 1975806373
adjuvant activity of mycobacterial fractions. i. purification and in vivo adjuvant activity of cell wall skeletons of mycobacterium bovis bcg, nocardia asteroides 131 and corynebacterium diphtheriae pw8.the adjuvant activity of cell wall skeletons (mycolic acid-arabino-galactan-mucopeptide, cws) prepared from the cells of mycobacteria, nocardia and corynebacteria was examined in vivo in mice and guinea pigs. the cell wall skeletons of mycobacterium bovis bcg (bcg-cws), nocardia asteroides 131 and corynebacterium diphtheriae pwc suspended in freund's incomplete adjuvant (fia) as water-in-oil emulsions showed potent adjuvant activity on the formation of circulating antibody and cell-mediated immu ...1975807194
a numerical taxonomic study of coryneform and related bacteria.two hundred and thirty-three strains of coryneform bacteria, including representatives of the genera arthrobacter, brevibacterium, cellulomonas, corynebacterium, erysipelothrix, jensenia, kurthia, listeria, microbacterium, mycobacterium, nocardia and propionibacterium and other related bacteria, were studied using 173 morphological, physiological and biochemical tests. the bacteria were grown on a soil extract medium which allowed growth of all the strains, and all were incubated at 30 degrees c ...1975805825
substituted 1-[(5-nitrofurfurylidene)amino]-4-imidazolin-2-ones.a series of 1-[(5-nitrofurfurylidene)amino]-4-imidazolin-2-ones has been prepared. a new synthesis of 4-alkyl-1-[(5-nitrofurfurylidene)amino]-4-imidazolin-2-ones involving the oxidative ring closure of 5-nitro-2-furaldehyde 2-(2-hydroxyethylalkyl)semicarbazones is described. the in vitro testing of the compounds against a variety of bacteria is reported.1975807733
effect of corynebacterium parvum on the course of a listeria monocytogenes infection in normal and congenitally athymic (nude) mice.spleen counts of listeria monocytogenes in normal mice challenged with various numbers of organisms were generally lower in mice injected 3 days previously with killed corynebacterium parvum. this increased resistance was unexpected since c. parvum generally inhibits t cell-mediated immunity, the functional immunity against listeria being t cell-dependent. the inhibitory effect on t cells seemed to be compensated by the stimulatory effect of c. parvum on macrophages. therefore, the experiments w ...1975808049
the bacteriological quality of hemodialysis solution as related to several environmental factors.the bacterial concentrations of the municipal water increased by more than 39-fold when subjected to reverse osmosis; then decreased by greater than 200-fold within the reservoir and water supply system of the hemodialysis center. the bacterial concentrations of dialysate solutions in contact with proportioning single-pass artificial kidney machines were as low or lower than the water from the hemodialysis center system (less than 10 cfu/100 ml.). the complete opposite was observed in the recirc ...1975807862
herd incidence of bovine mastitis in four danish dairy. districts ii. evaluation of the effect of the mastitis control scheme.bacteriological and cytological examinations have been carried out on samples from 6,808 cows belonging to 339 herds in four danish dairy districts. after a discussion of differences between the districts as regards intensivity of mastitis control, public health surveillance, etc., definitions are given of certain terms, such as presence of bacteria, infection, pathogenic versus non-pathogenic (less pathogenic) organisms. the rate of infection with pathogenic organisms varies between districts f ...1975807908
[effect of long-term freezing preservation on the level of bacterial contamination of the sperm].fourty-five ejaculates of breeding bulls were examined at a breeding station in order to study the contamination level of sperm after ejaculation, after thinning, after finished equilibration, after freezing, and after three months after placement in liquid nitrogen at -- 196 degrees c. the amount of germs in sperm was found to increase rapidly in the course of examination and thinning at laboratory temperature. the average number of 4,149 germs increased to 9,729. during equilibration the numbe ...1975808013
skin infections and the epidemiology of diphtheria: acquisition and persistence of c diphtheriae infections.acquisition and persistence of c. diphtheriae infections of skin lesions and of the respiratory tract were observed in households exposed to c. diphtheriae carriers in a community experiencing a diphtheria outbreak and in households in two communities free of the disease. acquisition of c. diphtheriae was more frequent in epidemic households, apparently due to a greater frequency of respiratory tract acquisition. skin lesion acquisition was constant in both situations. the pattern of persistence ...1975808123
evidence for an infectious etiology of rheumatoid arthritis. 1975808992
[effect of immunostimulation by corynebacterium parvum on evolution and metastatic dissemination of lewis's tumor in mouse c57bl/6 mice].treatment with corynebacterium parvum (c. parvum) produces a significant prolongation of survival time of lewis tumor bearing animals and reduces strikingly the incidence of pulmonary metastasis in syngeneic c57bl/6 mice. on the other hand, treatment with imuran, a known immunodepressive agent, reduces survival time and facilitates metastatic dissemination in the same model.1975809167
scabies and other skin diseases in pre-school children in ujamaa villages in tanzania.a survey of skin diseases was carried out in pre-school children in five ujamaa villages in rufiji district and 532 children (5.3% of the total population) were screened. the results showed that scabies was the commonest skin problem affecting 31% of the children. primary pyoderma and fungal infections were relatively less common and accounted for 7.0 and 2.4% respectively. staphylococcus aureus, group a beta haemolytic streptococci and corynebacterium diphteriae were the commonest pathogeneic b ...1975810929
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