| antibacterial activity of efrotomycin. | efrotomycin is a narrow spectrum antibiotic. among the genera tested for susceptibility in vitro it is most active against isolates of moraxella, pasteurella, yersinia, haemophilus, streptococcus and corynebacterium. the drug is as active by oral administration as by the subcutaneous route. blood levels rise rapidly to high concentrations, after oral dosing, and are prolonged. two peaks occur which may indicate biliary excretion and reabsorption. urinary excretion is minimal. the high blood conc ... | 1976 | 994327 |
| new approach to steroid conversion using activated immobilised microorganisms. | | 1976 | 995196 |
| decreased liver and lung drug-metabolizing activity in mice treated with corynebacterium parvum. | injections of killed suspensions of corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. in vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. it is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently ... | 1976 | 1000491 |
| in vitro behavior of corynebacterium parvum-activated cytotoxic macrophages. | | 1976 | 1003401 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. iii. effect of c. parvum on cyclophosphamide metabolism. | results of investigations employing [14c]cyclophosphamide (cy) demonstrated that even though total plasma radioactivity was similar in female c3heb/fej mice treated either with cy alone or corynebacterium parvum and cy, the proportion of total activity due to nonmetabolized cy was greater when c. parvum was used. these findings indicated that the antitumor effect of c. parvum may not have been entirely due to its immunopotentiating properties but may also have been related to its effect on the m ... | 1976 | 1003505 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. | the cytotoxic macrophage was further characterized as an important effector cell in the inhibition of tumor growth. when we administered rifampin (a semisynthetic antibiotic that interferes with macrophage function but not viability) with corynebacterium parvum and/or cyclophosphamide to tumor-bearing c3heb/fej female mice, the tumor growth-inhibitory effects of the c. parvum were reduced. moreover, when bone marrow cells from those animals were cultured, we found a marked decrease in the cytoto ... | 1976 | 1003514 |
| [survival of epiphytic microorganisms following sublimation dehydration and storage]. | epiphytic microorganisms belonging to the genera pseudomonas, agrobacterium, achromobacter, flavobacterium, mycobacterium, mycococcus, nocardia, corynebacterium, arthrobacter, bacillus, and microbacterium were dehydrated by sublimation employing two suspension media, and were stored at 3-5 degrees c during 1-2.5 years. survival of epiphytic microorganisms upon dehydration by sublimation and storage was found to depend on their taxonomy (genus, species, strain) and the composition of the suspensi ... | 1976 | 1004279 |
| endocarditis caused by actinomyces viscosus. | a case of severe endocarditis caused by actinomyces viscosus is described in a previously healthy 70-year-old man. the isolated strain has been characterized by biochemical tests, gas-liquid chromatography and serology. the pathogenic significance of the organism is discussed and the difficulty in reaching a correct diagnosis due to the similarity to species of corynebacterium is pointed out. | 1976 | 1006175 |
| [pig urinary tract infection with corynebacterium suis: diagnosis by means of immunofluorescence]. | | 1976 | 1006295 |
| studies on the host phage systems of corynebacterium murium species. the phage test in the etiologic diagnosis of corynebacterium infectons in mice. | | 1976 | 1008693 |
| effects of corynebacterium parvum alone and in combination with adriamycin in experimental tumor systems. | corynebacterium parvum (c. parvum) was used in antitumor tests against four murine tumor models in b6d2f1 mice. the c. parvum was effective at all doses and schedules tested against p388 leukemia, b16 melanoma, and lewis lung carcinoma but was ineffective against l1210 leukemia. combination immunochemotherapy of p388 leukemia and lewis lung carcinoma with c. parvum and adriamycin was better than either regimen alone in increasing the lifespan of mice with tumors. the results show that the effect ... | 1976 | 1009517 |
| microbial flora of normal canine conjunctivae. | | 1976 | 1011806 |
| [difficulties in the diagnosis and evaluation of the severity of acute aortic insufficiency in bacterial endocarditis]. | | 1976 | 1013706 |
| bacterial carotenoids. l. absolute configuration of zeaxanthin dirhamnoside. | zeaxanthin dirhamnoside is the major carotenoid of corynebacterium autotrophicum. the absolute configuration 3r,3'r followed from cd-properties of its hexaacetate, alpha-l-assignment and 1c4 conformation were concluded from 1h nmr data by comparison with model compounds. | 1976 | 1015942 |
| microbiological degradation of bile acids. the conjugation of a certain cholic acid metabolite with amino acids in corynebacterium equi. | 1. (4r)-4[4alpha-(2-carboxyethyl)-3aalpha-hexahydro-7abeta-methyl-5-oxoindan-1beta-yl]valeric acid (ii) could not be utilized by arthrobacter simplex, even though the acid was one of the metabolites formed from cholic acid (i) by this organism. therefore the further degradation of the acid (ii) by corynebacterium equi was investigated to identify the intermediates involved in the cholic acid degradation. 2. the organism, cultured in a medium containing the acid (ii) as the sole source of carbon, ... | 1976 | 1016254 |
| a lipid chemotactic factor from anaerobic coryneform bacteria including corynebacterium parvum with activity for macrophages and monocytes. | a lipid with chemoattractant (chemotactic) activity for mouse and guinea-pig macrophages and for human blood monocytes is released by anaerobic coryneform bacteria (including corynebacterium parvum). the active lipid is associated with fibrillar structures which lie on the outside of the bacterial cell and are released spontaneously during growth. the lipid can also be extracted easily by a number of methods. the fibrils are loosely associated with a capsule-like structure composed largely of po ... | 1976 | 1027716 |
| acute conjunctivitis in a rural egyptian community. | | 1976 | 1031072 |
| an investigation on the decarboxylase activity of human and animal diphtheroids. | | 1976 | 1032382 |
| immobilization and steroid-transforming microorganisms in polyacrylamide. | | 1976 | 1035786 |
| infection of a nonspecific urethritis patient and his consort with a pathogenic species of nonspecific urethritis corynebacteria, corynebacterium genitalium, n. sp. | a patient with nonspecific urethritis (nsu) and his consort were examined for infection with nsu corynebacteria, mycoplasmas, and gonococci. no classic and t-mycoplasmas or gonococci were cultured, but one species of nsu corynebacteria was isolated not only from the patient's urethral discharge during three episodes of nsu but also from his consort. it was not isolated after successful treatment of the patient with tetracycline and the use of condoms prevented reoccurrence of urethritis. this ns ... | 1976 | 1036491 |
| corynebacterium pseudotuberculosis as a cause of subacute interstitial nephritis in a chimpanzee. | | 1976 | 1048802 |
| a simple method for estimating viable filamentous bacteria in plaque. | | 1975 | 1053770 |
| [management of acute leukemias and linphosarcomas with active immunotherapy (author's transl)]. | | 1975 | 1056311 |
| enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection. | in studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. in contrast the application of cytostatic drugs and of corynebacterium parvum could modify the pulmonary resistance to the formation of tumour nodules by a factor greater than 100 in either direction. this ... | 1975 | 1056314 |
| contamination of fluids from a hospital pharmacy. | an investigation into the cause of bacterial contamination of bottles of noninjectable water has been reported. a method of monitoring such bottles has also been described. the roles played by autoclave spray-cooling water and inadequate bottle seals in the contamination of fluids have been examined. possible methods of reducing the risk of contamination are discussed and the design of an improved method of closure of sterile bottled fluids is stressed. bacteriological examination is shown to be ... | 1975 | 1056972 |
| new experimental and clinical data on leukaemia immunotherapy. | the present results of our treatment of acute lymphoid leukaemia patients are summarized: 7 out of 20 randomized patients given active immunotherapy after chemoradiotherapy are still in complete remission after periods varying from seven to ten years (compared to none in the control group). the actuarial results on 100 patients show remission and survival curves presenting a plateau between three and five years for a certain percentage, suggesting a possible cure. several parameters studied in 2 ... | 1975 | 1060146 |
| studies on the enhancement by cyclophosphamide (nsc-26271) of artificial lung metastasis after labeled cell inoculation. | in a mouse model the retention of125i-5-iodo-2' -deoxyuridine-labeled tumor cells in the lung after iv injection was compared with the formation of tumor colonies in the lung 15 days after injection. the modification in lung retention after treatment with cyclophosphamide (cp), isophosphamide, corynebacterium parvum, and heparin paralleled the changes in lung-colony numbers by these treatments. since the modifications could be identified as early as 1 hour after iv administration of tumor cells, ... | 1976 | 1064469 |
| identification of the cultivable bacteria in dental plaque from the beagle dog. | fifteen different genera of microorganisms were isolated from the 27-month-old plaque of two beagle dogs. they were as follows: pseudomonas, proteus, neisseria, escherichia, staphylococcus, streptococcus, lactobacillus, nocardia, actinomyces, corynebacterium, micrococcus, microbacterium, brevibacterium, arthrobacter, and kurthia. the dog plaque was characterized by a low number of streptococci and the presence of several noncarbohydrate-fermenting organisms. | 1976 | 1069758 |
| mechanisms of macrophage activation by corynebacterium parvum. ii. in vivo experiments. | | 1975 | 1079165 |
| correspondence on the study "isolation and identification of corynebacterium vaginale (haemophilus vaginalis) in women with infections of the lower genital tract". | | 1975 | 1079680 |
| daily intravenous infusions of corynebacterium parvum in twenty patients with disseminated cancer: a preliminary report of clinical and biologic findings. | twenty terminally ill patients with various disseminated tumors were treated with daily iv infusions of corynebacterium parvum given alone at doses of 4 mg/day, 5 days/week, for 4-16 weeks. in 8 patients (40%), the lesions partially regressed to less than 50% of their original size. another patient who did not improve with c. parvum therapy had a complete remission after the first course of chemotherapy. skin tests, total leukocyte counts, and t- and b-cell counts revealed variable and unpredict ... | 1975 | 1080521 |
| effect of local injection of corynebacterium parvum on the growth of a murine fibrosarcoma. | local injection (i.e. injection at the site of tumour inoculation) of strains of c. parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact cba mice but has little or no effect on subcutaneous transplants of the same tumour in t-cell deprived mice. the anti-tumour effect of local injection of c. parvum, unli ... | 1975 | 1080671 |
| obligately anaerobic strains of corynebacterium vaginale (haemophilus vaginalis). | six obligately anaerobic strains of corynebacterium vaginale (haemophilus vaginalis) have been isolated and their characteristics studied. the reactions of the anaerobic strains, as well as of facultative strains tested under anaerobic conditions, are similar to the reactions previously reported for this species. | 1975 | 1080766 |
| active specific immunotherapy of mouse methylcholanthrene induced tumours with corynebacterium parvum and irradiated tumour cells. | the relative efficiency of active nonspecific or specific immunotherapy of developing methylcholanthrene induced fibrosarcomata with c. parvum was compared. for nonspecific immunotherapy, mice were challenged with tumour cells s.c. or i.v., and 2 days later injected i.v. with dilutions of c. parvum. the only significant effect was a retardation of s.c. tumour growth by the highest concentration of c. parvum (350 mug). however, active specific immunotherapy, using mixtures of c. parvum and irradi ... | 1975 | 1082344 |
| the accumulated effects of repeated systemic or local injections of low doses of corynebacterium parvum in mice. | the effects of 14 weekly injections, s.c. or i.v., of "human equivalent" doses (5.25 mg/sq m) of corynebacterium parvum (cp) in mice have been compared. both s.c. and i.v. cp caused significant splenomegaly and antibody to cp, but stimulation was considerably greater after i.v. cp. delayed hypersensitivity levels to cp were similar after s.c. and i.v. injection. t-cell competence, as judged by phytohemagglutinin reactivity and delayed hypersensitivity to sheep cells, was unimpaired after s.c. cp ... | 1976 | 1083289 |
| effect of corynebacterium parvum on cellular and humoral antitumoral immune effector mechanisms. | | 1976 | 1083341 |
| the effect of corynebacterium parvum on the humoral and cellular immune systems in patients with breast cancer. | corynebacterium parvum, a gram-positive anaerobic bacillus thought to be a strong immunological stimulant, has been shown to decrease tumour growth and prolong survival in patients with metastatic disease. study of the effect of a single injection of a strain of c. parvum (cn. 6134) in six patients with stage iv metastatic breast cancer is reported. results of laboratory tests to judge the physical and immunological effects of the drug infusion 24 hr post-treatment and weekly thereafter for 3 we ... | 1976 | 1084821 |
| comparison of isolation of haemophilus vaginalis (corynebacterium vaginale) from peptone-starch-dextrose agar and columbia colistin-nalidoxic acid agar. | a total of 447 cervical or vaginal specimens were inoculated in parallel onto peptone-starch-dextrose (psd) and columbia colistin (10 mg/ml)-nalidixic acid (15 mug/ml) (cna) agar and were incubated for 48 h at 35 degrees c in an atmosphere with 2 to 10% co2. one hundred (22.4%) of the cultures were positive for haemophilus vaginalis. forty-eight of the isolates were recovered from both psd and columbia cna agar, five from psd only, and 47 from columbia cna agar only (p less than 0.001). on colum ... | 1976 | 1085777 |
| corynebacterium vaginale (hemophilus vaginalis) bacteremia: clinical study of 29 cases. | twenty-nine patients with bacteremia due to corynebacterium vaginale, an inhabitant of the female genital tract, are described. four were newborn babies. nineteen were healthy young women delivered at full term by an operative procedure, cesarean section, or episiotomy. within 48 hours fever and bacteremia developed. while receiving antibiotics the fever returned to normal, usually within 48 hours. the remaining cases were associated with septic abortion, tubal pregnancy, an intrauterine device, ... | 1976 | 1085832 |
| mechanisms of antitumor action of corynebacterium parvum: replicating short-lived t cells as the mediators of potentiated tumor-specific immunity. | | 1976 | 1086362 |
| cancer active immunotherapy. immunoprophylaxis and immunorestoration. an introduction. | | 1976 | 1087040 |
| epidemiologic characteristics of women infected with corynebacterium vaginale (haemophilus vainalis). | in a group of 184 women infected with corynebacterium vaginale (haemophilus vaginalis), 34% over age 30 were divorced or separated and 8% gave a history of induced abortion. fifty-one percent were taking an oral contraceptive drug, as compared to 36% of 140 women in a control group. various sexually transmitted diseases were diagnosed either concomitantly or at another time in 52% of women in the study group and 38% of those in the control group. the rate of cervical neoplasia (invasive carcinom ... | 1976 | 1087635 |
| canine granulocytopathy syndrome: neutrophil dysfunction in a dog with recurrent infections. | a male irish setter dog had a clinical history of recurrent life-threatening bacterial infections, with associated periods of pyrexia and severe neutrophilia. examination of a mandibular lymph node biopsy made when the patient was 10 weeks old revealed subacute diffuse suppurative lymphadenitis with reticuloendothelial hyperplasia. circulating leukocytes isolated from the dog when it was 5 months old had a marked bactericidal defect when compared with cells from clinically normal dogs of the sam ... | 1975 | 1089620 |
| genetic basis of toxin production and pathogenesis in vibrio cholerae: evidence against phage conversion. | the pathogenicity of vibrio cholerae strains "cured" of "kappa-type" phage was not significantly altered relative to that of their "kappa" lysogenic parental strains. unlike corynebacterium diphtheriae, the capacity of v. cholerae to produce exotoxin was not stimulated as a consequence of active phage multiplication. toxin production in cultures in which kappa-type phage multiplication was initiated either by inducing kappa lysogens or by infecting naturally occurring or "cured" kappa-sensitive ... | 1975 | 1090531 |
| trichomoniasis, candidiasis, and the minor venereal diseases. | | 1975 | 1091389 |
| mechanisms of macrophage activation by corynebacterium parvum. i. in vitro experiments. | | 1975 | 1092470 |
| effect of corynebacterium parvum on the class and subclass of antibody produced in the response of different strains of mice to sheep erythrocytes. | several strains of mice were injected with sheep erythrocytes (srbc) using c. parvum as adjuvant. the adjuvant effects on the amounts of class and subclass of antibody produced were ranked in the order igg2b greater than igg2a and igm greater than igg1. in addition, these effects were shown to vary depending on the time of administration of c. parvum relative to antigen. c parvum was shown to have no adjuvant effect on the response of congenitally athymic mice when given at the same time as the ... | 1975 | 1092609 |
| rejection of mammary adenocarcinoma cell tumors in dba/2 mice immunocompromised by thymectomy and treatment with antithymocyte serum. | syngeneic mammary adenocarcinoma cells were mixed with killed corynebacterium parvum organisms and were then transplanted subcutaneously into groups of normal and immunocompromised mice. the tumors formed at the site of injection exhibited normal growth for approximately 12 days followed by rapid and lasting rejection in both normal and immunocompromised animals. the control mice were protected against reinjections of 10-4 to 10-8 cells of the same line of tumor cells. the immunocompromised mic ... | 1975 | 1092759 |
| production and characterization of exotoxin(s) of shigella dysenteriae type 1. | a semicontinuous fermenter system was developed in which broth culture filtrates of shigella dysenteriae type 1 yielded substantial amounts of exotoxin. biologic activity of the exotoxin was characterized by means of three assays: the rabbit ileal loop for fluid evocation (enterotoxicity), mouse lethality after parenteral injection (neurotoxicity), and hela cell toxicity in vitro (cytotoxicity). although the culture filtrate was highly active, disc electrophoresis revealed that the toxin is a mi ... | 1975 | 1092769 |
| tumor inhibitory properties of anaerobic corynebacteria. | | 1975 | 1093294 |
| [active immunotherapy of acute leukemia and leukemic lymphosarcoma. results of 10 years. study of 200 cases]. | the authors report a ten year study of active immunotherapy using bcg and irradiated allogeneic leukaemic cells in 200 patients. in acute lymphatic leukaemia, 57 out of 168 patients treated in this way remained in primary remission for 18 months to 10 years after active immunotherapy was begun, the relapse rate became low after 18 months and nil after 36 months. the results varied according to prognostic factors: the cytological type, active immunotherapy being above all effective in small cell ... | 1975 | 1098015 |
| bacterial flora of the normal conjunctiva. ii. methods of obtaining cultures. | the methods used for obtaining bacterial cultures from the normal conjunctiva were reviewed. a comparison was made between four methods; a) platinum loop, b)calcium alginate swab c) dry, and d) wet cotton wool swab, using agar (all methods) and serum-bouillon (methods b, c, d) as culture media. the comparisons were based on the isolation rate of staphylococcus albus and corynebacteria. at the same time, four topical anaesthetics (benoxinate, tetracaine, proparacaine, cocaine) and one vital stain ... | 1975 | 1098381 |
| [a study on the nature of corynebacterium acnes (author's transl)]. | | 1975 | 1099281 |
| the effect of medium composition on the production of valine by corynebacterium 9366 - ems/184. | the auxotrophic mutant corynebacterium 9366-ems/184, requiring isoleucine accumulates about 22 g of l-valine per litre after a 96 h cultivation in a medium containing 15% sucrose and 1% ammonium acetate. | 1975 | 1100493 |
| [protective effects of bacterial immunostimulants in mice infected by "klebsiella pneumoniae" resistant to antibiotics after mutation or by plasmid transfer]. | a streptomycin-resistant strain of k. pneumoniae obtained after mutation in vitro was found to be less virulent than the sensitive strain in mice. however, a single injection of lipopolysaccharides (lps) administered 24 hours before challenge increased the host's resistance to both strains. in contrast, the virulence was not changed in k. pneumoniae accepting r-factors for ampicillin, streptomycin, chloramphenicol, tetracycline and sulphonamide. the plasmids were transferred to k. pneumoniae fro ... | 1975 | 1101801 |
| the role of macrophages in the amplified in vitro response to sheep red blood cells by spleen cells from corynebacterium parvum treated mice. | | 1975 | 1102113 |
| nonspecific enhancers of resistance in man. | nonspecific enhancers of resistance may include (1) viral interference, (2) interferon, (3) interferon inducers, (4) bacterial interference, (5) bacterial products such as coley's "toxins," endotoxins, or staphylococcal, bcg, and corynebacterium parvum vaccines, (6) transfer factor, and (7) well-defined chemicals such as dinitrochlorbenzene, levamisole, and vitamin c. these are discussed only as they have been applied to man to learn whether or not they have enhanced his ability to resist infect ... | 1975 | 1102645 |
| bacterial flora in relation to cataract extraction. iii. postoperative flora. | the conjunctival flora of 499 patients operated for cataract was studied on the 4th and 7th postoperative days and compared with the flora examined previously on admission to the hospital and at the time of surgery (fahmy et al. 1975b, c). antibiotics had been administered approximately 18 hours before operation, at the conclusion of surgery, and then on the 4th postoperative day after the cultures had been taken. after a significant fall in incidence, including all kinds of bacteria at the time ... | 1975 | 1103562 |
| [clinical studies of the antifungal and antibacterial activity of haloprogin]. | | 1975 | 1105172 |
| [a hypophysis-abscess-syndrome in cattle. i. clinical investigations (author's transl)]. | | 1975 | 1105401 |
| preweaning mortality in pigs. 6. incidence and causes of pneumonia. | | 1975 | 1105402 |
| preweaning mortality in pigs. 7. polyarthritis. | the incidence and causes of polyarthritis in sucking pigs were studied in herds with 2,936 litters during a 2-year period. among pigs more than 3 days old, the average morbidity rate was 3.3 per cent and the mortality rate amounted to 1.5 per cent (table i). among herds the morbidity ranged from 0.9 to 7.0 per cent and the mortality due to polyarthritis from 0.5 to 2.8 per cent. the incidences of polyarthritis were higher in the progeny of gilts than in the progeny of sows of other age groups (t ... | 1975 | 1105403 |
| nonspecific immunotherapy of malignant tumors. | at present, nonspecific immunotherapy of malignant tumors seems to be the most promising among immunotherapeutic modalities. potent nonspecific immunostimulants, bacillus calmette-guerin (bcg) and corynebacterium parvum, exhibit an antitumor activity in experimental animals, which is commonly manifested by reduced tumor growth and sometimes by complete regression of tumors. antitumor effectiveness of these bacteria is largely related to tumor immunogenicity and host immunocompetence. recently, b ... | 1976 | 1105663 |
| [sensitivity of mastitis pathogens to antibiotics and chemotherapeutic agents]. | sensitivity of mastitis bacteria to antibiotics and chemotherapeutic agents. the author tested the following bacteria, isolated from milk: -2236 strains of streptococci (1384 of group b, 262 of group c, 62 of group d, 109 of e, 16 of f, 24 of g, 7 of h, 11 of k, 270 of l, 5 of m, 41 of n, 45 of p); 361 ungroupable streptococci; 18,481 camp-positve, 1,966 camp-negative beta-haemolytic streptococci; 5,403 camp-negative, non-haemolytic streptococci; 1,179 strains of staphylococci, 596 of coliforms, ... | 1975 | 1106346 |
| effects of bcg, corynebacterium parvum, and methanol-extration residue in the reduction of mortality from staphylococcus aureus and candida albicans infections in immunosuppressed mice. | an immunosuppressed mouse model was devised to test the effects of immunopotentiators on the prevention of bacterial and fungal infections. the effects of bcg and corynebacterium were tested against staphylococcus aureus and candida albicans infection. the effect of methanol-extraction residue (mer-bcg) was tested against s. aureus septicemia. cdf mice were given various doses of bcg, 1.0 mg of c. parvum, or 0.5 mg of mer intraperitoneally at varying intervals before injection of an intravenous ... | 1975 | 1107224 |
| inhibitory effect of prolonged corynebacterium parvum and cyclophosphamide administration on the growth of established tumors. | the present study was carried out to investigate the effects of prolonged administration of c. parvum alone and in combination with cyclophosphamide for the treatment of established, measurable c3h tumors. the continued weekly administration of c. parvum by itself provided a limited but significant inhibitory effect on tumor growth and significantly prolonged survival. intraperitoneal and intravenous administration was found to be more effective than the subcutaneous route. when c. parvum was ad ... | 1975 | 1109767 |
| specific and nonspecific stimulation of resistance to the growth and metastasis of the line 1 lung carcinoma. | the effects of specific dead tumor cell immunization and nonspecific immunostimulation with corynebacterium parvum on the s.c. growth of the line 1 carcinoma in syngeneic balb/c mice have been studied. injection of heavily irradiated line ) carcinoma cells did not inhibit the transplantability or growth of the line 1 carcinoma, and in certain cases these treatments actually prolonged the period of rapid growth. this latter observation was traced to a mild inhibition of metastatic spread, which i ... | 1975 | 1109793 |
| charcterization and physiological function of a soluble l-amino acid oxidase in corynebacterium. | a general l-amino acid oxidase (l-amino acid: oxygen oxidoreductase (deaminating), ec(1.4.3.2) has been characterized in corynebacterium. the enzyme is soluble (mw 130000-140000) and is active with most l-alpha-amino acids but not with aspartate, threonine, proline and glycine. it is subject to substrate inhibition. this amino acid oxidase is induced along with catalase by growth in the presence of amino acids as a nitrogen source and is repressed when ammonium ions are present in the medium. it ... | 1975 | 1115559 |
| proceedings: combined surgery and corynebacterium parvum for treatment of metastasizing tumour in mice. | | 1975 | 1115892 |
| proceedings: the action of subcutaneous and intravenous corynebacterium parvum on the "lymphocyte trap". | | 1975 | 1115893 |
| a comparative study of anaerobic coryneforms. attempts to correlate their anti-tumour activity with their serological properties and ability to stimulate the lymphoreticular system. | various strains of anaerobic coryneforms and the closely related propionibacteria have been compared in vivo with respect to their anti-tumour activity. their effectiveness has been correlated with their serological relationship and to some extent with their ability to stimulate the lymphoreticular system. organisms belonging to corynebacterium acnes groups i and ii and c. avidum group iv were active anti-tumour agents, although of varying effectiveness. these strains are serologically closely r ... | 1975 | 1116870 |
| the survival and growth of microorganisms in mascara during use. | over 150 mascaras representing eight popular brands were examined for their susceptibility to microbial contamination during their use by study group members. additional mascaras from patients with symptoms and clinical findings of long-term blepharitis also were investigated. early in the study, two brands without preservatives supported reproducing populations of microorganisms, including potential eye pathogens. these products, as currently manufactured, were recalcitrant to microbial attack. ... | 1975 | 1119519 |
| changes of adrenal hormones in goats with experimentally induced arthritis. | an experiment was carried out to clarify the mechanism of occurrence of arthritis in goats. in it changes of the adrenal hormones in blood and urine were examined in goats with experimentally induced arthritis. four groups of goats were used. a goat of group b was inoculated with anaerobic corynebacterium organisms isolated from a joint of a field case. group h was treated with hormones (deoxycorticosterone acetate and adrenalin). group bh was inoculated with those organisms and treated with the ... | 1975 | 1121333 |
| effect of corynebacterium parvum on bone marrow cell cultures (38557). | the effect of c. parvum on in vitro colony-forming cell was evaluated. a single ip injection of the vaccine had no effect during the first 4 hr either on colony stimulating factor or on colony-forming cells. the enhancement of the colony-forming capacity of the bone marrow by c.parvum occurred after two injections of the vaccine within 48 hr. the stimulation of colony formation by c. parvum was time related function and occured 5 days after the initiation of the cultures. the results of this ... | 1975 | 1121493 |
| bovine mastitis in bulgaria. | | 1975 | 1121745 |
| changes in cutaneous flora after wet occlusion. | aerobic flora from wet-occluded forearms of six volunteers was sampled the day before treatment, on the 3rd day when dressings were removed, and daily, when possible, for 8 days thereafter. erythema was not present. all bacterial colonies appearing on appropriate dilution plates were identified with the aid of a replica-plating technique. flora of each individual increased to over 10-4 colony-forming units/cm2 as a result of wet-occlusion, but counts rapidly fell by about 10-2 units once dressin ... | 1975 | 1122426 |
| self-assessment mini-program. | | 1975 | 1123262 |
| the microbial metabolism of di-n-butyl phthalate and related dialkyl phthalates. | | 1975 | 1125463 |
| differentiation of arthrobacter soil isolates and named strains from other bacteria by reations on dye-containing media. | twenty-five gram-negative and 62 gram-positive bacterial cultures, of which 37 werearthrobacters, were tested, using a multipoint inoculation device, for responses on varying concentrations of 35 dyes. both selective (growth vs. no growth) and differential (dye absorption) responses were obtained. it was possible to differentiate the arthrobacters from the other gram-positive bacteria tested as well as to distinguish separately each arthrobacter-named strain. the results indicated that dyes have ... | 1975 | 1125859 |
| nonspecific immunotherapy of murine solid tumors with corynebacterium granulosum. | a single intraperitoneal (ip) or intravenous (iv) injection of corynebacterium granulosum into c3hf/bu mice shortly after subcutaneous (sc) injection of cells from a strongly antigenic syngeneic fibrosarcoma induced by 3-methylcholanthrene caused complete and lasting regressions of 100 and 70% of resulting tumors, respectively. treatment with this bacterium sc only slightly inhibited the growth of some tumors. c. granulosum given iv to mice 3 days after the sc injection of fibrosarcoma cells cau ... | 1975 | 1127718 |
| corynebacterium bovis as a pathogen in rabbits. | a corynebacterium identified as corynebacterium bovis has been isolated from a chronic testicular abscess and the lung of a laboratory rabbit. the strain, on intravenous injection, reproduced a similar disease in the inguinal and vulval region of an experimental rabbit. sera from both animals showed increasing titres of agglutinating antibody for the isolated corynebacterium and for kaolin particles sensitised with the phosphatide antigen of mycobacterium tuberculosis. it is suggested that the p ... | 1975 | 1129540 |
| the use of mouse protection tests in the diagnosis of caseous lymphadenitis in sheep. | mouse protection tests gave promising results in the diagnosis of caseous lymphadenitis in sheep especially those presenting no external lesions. the test was specific since sera of infected sheep were capable of neutralising corynebacterium ovis toxin while sera of healthy sheep failed to do so. better results were obtained with 1-0 ml than 0-5 or 0-25 ml serum of infected sheep to neutralise 2 mld of the toxin through mice. | 1975 | 1129543 |
| general discussion: treatment of prostatic cancer. | | 1975 | 1131805 |
| radiation response of c3h fibrosarcoma enhanced in mice stimulated by corynebacterium parvum. | | 1975 | 1138200 |
| cell wall-deficient bacterial variant cultural surveillance. a useful laboratory aid. | a cell wall-deficient variant of corynebacterium species was isolated from the blood of a patient with a chronic febrille illness of unkown etiology. he was given antimicrobial therapy, to which both variant and reverted bacterial forms of this organism were sensitive, and he recovered. cultural surveillance for cell wall-deficient organisms was not only helpful in confirming the presence of infection in our patient but also in following his clinical course once antimicrobial therapy had been in ... | 1975 | 1138544 |
| treatment of discospondylitis in the dog. | a combination of spinal cord decompression, spinal column immobilization, and systemic antibiotic therapy was used to treat discospondylitis in 30 dogs. recovery was complete in 7 of 9 dogs with cervical involvement and in all 21 dogs with thoracolumbar involvement. | 1975 | 1141033 |
| proceedings: cell-wall composition of aerobic cutaneous "diphtherios" organisms. | | 1975 | 1142405 |
| isolation of cyclic 3',5'-pyrimidine mononucleotides from bacterial culture fluids. | | 1975 | 1147989 |
| posthitis in angora wethers. | posthitis was diagnosed as an economic problem of angora wether goats. affected goats had a scabby or ulcerated prepuce, with a distorted or pinhole preputial orifice. some goats were able to urinate only by excessive straining. cultural examination revealed a corynebacterium sp capable of hydrolyzing urea, similar in all respects to the organism associated with a similar problem with merino wethers in australia. necessary predisposing factors are considered to be a castrated animal consuming a ... | 1975 | 1150508 |
| the specificity of enzymes adding amino acids in the synthesis of the peptidoglycan precursors of corynebacterium poinsettiae and corynebacterium insidiosum. | a soluble extract from corynebacterium poinsettiae able to synthesize the nucleotide precursor of ite peptidoglycan was prepared. this extract contained all the enzymes necessary for the synthesis of the peptide side-chain. the spedificity of these enzymes was determined and compared with the specificity of similar enzymes extracted from the closely related corynebacterium insidiosum. in both organsims, addition of the third amino acid of the peptide side-chain was specific for the amino acid an ... | 1975 | 1151331 |
| differentiation of mycobacterium, nocardia, and related taxa by thin-layer chromatographic analysis of whole-organism methanolysates. | | 1975 | 1151335 |
| [analysis of a group of corynebacterium by numerical taxonomic methods]. | strains (29) of corynebacterium genus were studied with the use of the method of numerical taxonomy. 48 characteristics (including morphological, tinctorial, cultural and biochemical ones) were analyzed. all the strains tested proved to belong to the same taxon. the present method permitted to reveal various biotypes within the group studied. | 1975 | 1154942 |
| [microbial 3-o-demethylation and 3-o-methylation of estratrienes]. | estradiol-3-methylether, estrone-3-methylether, 17alpha-ethinyl-estradiol-3-methylether and other 17alpha-substituted estratrienes were 3-o-demethylated to free 3-hydroxy compounds by fermentation with corynebacterium sp. a hydroxy groupp in position 6alpha or 6beta prevented the reaction. the opposite reaction, methylation of the 3-hydroxy group of estratrienes, was performed using mycobacterium smegmatis. the substrate specifity of this methylation was low. analogies of these microbial reactio ... | 1975 | 1154945 |
| bacterial interference by streptococcus salivarius. | a strain of streptococcus salivarius, recognized in a throat culture because of its inhibition of the growth of a species of corynebacterium, was studied in vitro to determine its antagonistic effects agains various other bacteria. it was found to be inhibitory to anaerobic gram-positive cocci, streptococci belonging to lancefields groups a, c, f, and g, and corynebacterium diphtheriae, c. hofmanii, and c. xerosis. | 1975 | 1155368 |
| further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with corynebacterium parvum. | administration of c. parvum to both intact and thymectomized mice resulted in the appearance in the peritoneal exudate of cells which inhibited tumour growth in vitro. this effect was mediated by intact, viable adherent cells, which it seems reasonable to categorize as macrophages, and was contingent on contact between the effector and target cells. no co-operation was observed between lymph node cells from c. parvum treated mice and peritoneal exudate cells from normal mice. | 1975 | 1156505 |
| lack of immunological and anti-tumour effects of orally administered corynebacterium papvum in mice. | | 1975 | 1156520 |
| modifications in the handling in vitro of 125i-labelled keyhole limpet haemocyanin by peritoneal macrophages from mice pretreated with the adjuvant corynebacterium parvum. | peritoneal macrophages were isolated from c. parvum-pretreated (cp) and normal cbat6t6 mice and their in vitro handling of 125i-labelled keyhole limpet haemocyanin (125i-labelled klh) studied in relation to the humoral anti-klh responses induced in corresponding animals. cp pretreatment exerted an adjuvant effect on the production of anti-klh antibodies, both igm and igg, which was also demonstrable with a normally subimmunogenic dose of antigen. there was a clear difference between the handling ... | 1975 | 1158386 |
| the measurement of antidandruff efficacy. | | 1975 | 1158544 |
| in vitro destruction of tumor cells by macrophages from mice treated with corynebacterium granulosum. | peritoneal macrophages from c3hf/bu mice treated with killed corynebacterium granulosum bacteria were tested for their effect on in vitro growth of syngeneic fibrosarcoma cells, tumorigenic mouse l-p59 cells, human malignant melanoma cells, allogeneic fibroblasts, erythrocytes, and epithelial kidney cells. only the cell cultures having neoplastic properties were destroyed by stimulated macrophages; the rate of tumor cell destruction was greater as the ratio of effector to target cells was increa ... | 1975 | 1159835 |
| ventriculojugular shunt nephritis with corynebacterium bovis. successful therapy with antibiotics. | a patient with hydrocephalus and a ventriculojugular shunt presented with acute nephritis, nephrotic syndrome (proteinuria 10 g/24 hours), decreased complement levels, circulating immune complexes and diminished creatinine clearance (41 ml/min). seven blood cultures grew corynebacterium bovis. a renal biopsy specimen revealed mesangiocapillary glomerulonephritis by light microscopy, and thickened glomerular basement membranes with areas of increased granular density by electron microscopy. immun ... | 1975 | 1163549 |