| biphasic pattern of activation of the reticuloendothelial system by anaerobic coryneforms in mice. | macrophage activation as measured by increased rates of clearance of carbon was explored in five inbred and two outbred strains of mice pretreated with anaerobic coryneform bacilli. constant differences were found according to strain from dba (lowest response) to sha-sha (highest response). the investigation was continued with mice of cba strain which also provided highly reproducible and high-level responses. in this strain activation occurred in two phases: an early activation which reached ma ... | 1977 | 849877 |
| radiolabelling of corynebacterium parvum and its distribution in mice. | corynebacterium parvum was labelled by growing live bacteria in the presence of [3h]thymidine. the bacteria were killed by formalin, washed thoroughly and resuspended at a concentration of 7 mg dry weight/ml. an activity of 1-6 x 10(5) ct/min/0-1 ml was obtained. the biological properties (inhibition of tumour growth and hepatosplenomegaly) of the labelled c. parvum were compared with those of commercially available vaccine, and were found to be similar. labelled c. parvum was injected i.v., i.p ... | 1977 | 851511 |
| corynebacterium equi enteritis in foals. | corynebacterium equi is a pathogen associated with respiratory disease in the foal. this paper discusses two cases of corynebacterium equi infection, one acute and one chronic, in which the major damage was intestinal. necrosis of peyer's patches was the only lesion seen in the small intestine of both foals. the foal with acute disease had distinct green-tan focal necrosis and thickened mucosa of the large intestine. in the foal with chronic disease, the mucosa of the large intestine was thicken ... | 1977 | 857401 |
| foot ulceration and vertebral osteomyelitis with corynebacterium haemolyticum. | diphtheroid or "coryneform" bacilli are usually considered to be nonpathogenic "normal flora" of human skin and mucous membranes. because bacterial cultures are frequently contaminated with these organisms, the correct diagnosis and proper treatment may be delayed by the failure to recognize serious infections caused by them. this is a report of a 71-year-old woman with a diabetic foot ulcer and corynebacterium haemolyticum osteomyelitis with bacteremia. | 1977 | 857732 |
| effects of c. parvum on growth and induction of intracerebral tumours in mice. | an investigation was made into the effect of corynebacterium parvum therapy on cerebral tumours in mice. i.v. c. parvum caused a slight but significant increase in the survival of balb/c mice injected intracerebrally (i.c.) with not more than 50 meth a cells. c. parvum was most effective if given on the same day or 5 days after tumour. if this interval was increased there was no effect. multiple i.v. injections were no more effective than a single dose. i.v. c. parvum had no influence on the sur ... | 1977 | 857825 |
| [diphtheria epidemic occurring on the north shore of the st. lawrence river in the fall of 1974]. | an outbreak of diphtheria occurred on the north shore of the st. lawrence river at the beginning of september 1974. it started with the death of an 18-year-old forest worker sept. 5, spread over a vast area of the north shore and lasted until the end of october that year. eleven strains of toxigenic corynebacterium diphtheriae intermedium, type k were isolated. eleven of the 12 patients had characteristic diphtheritic pharyngitis with pseudomembranes. preventive measures, set forth immediately a ... | 1977 | 861886 |
| combined treatment with anaerobic corynebacterium liquefaciens and chemotherapeutics against solid tumor in mice. | the combined effect of anticancer agents (mitomycin-c, cyclophosphamide, or 5-fluorouracil) and anaerobic corynebacterium liquefaciens on subcutaneously induced solid ehrlich carcinoma in mice was examined. mitomycin-c and cyclophosphamide were given intraperitoneally on day 7 after inoculation of tumor cells. 5-fluorouracil was administered intraperitoneally for 7 consecutive days from day 9 to 15. c. liquefaciens was given in two ways, intraperitoneally and intratumorally. its injections were ... | 1977 | 863171 |
| inheritance of lipopolysaccharide-enhanced nonspecific resistance to infection and of susceptibility to endotoxic shock in lipopolysaccharide low-responder mice. | in a previous study, we demonstrated that lipopolysaccharide (lps) and other bacterial immunostimulants, in contrast to their activity in a closely related high-responder subline, failed to elicit nonspecific resistance in lps low-responder mice against klebsiella pneumoniae infection. to investigate the type of inheritance controlling the lps-induced nonspecific resistance to infection, the present study was performed in low- and high-responder c3h sublines and in f1 and f2 hybrids. in addition ... | 1977 | 863509 |
| an analysis of the factors allowing promotion (rather than inhibition) of tumour growth by corynebacterium parvum. | the following factors were found to determine whether c. parvum (cp) treatment promoted rather than inhibited the growth of methylcholanthrene-induced fibrosarcoma cells injected into cba mice. (1) the dose of tumour cells. promotion occurred only with low doses, around the td50. (2) the route of injection of cp. greater promotion was caused by intravenous (iv) than by subcutaneous (sc) administration. addition of irradiated tumour cells to sc cp resulted in tumour inhibition. (3) the dose of cp ... | 1977 | 863546 |
| effect of corynebacterium parvum, methanol-extraction residue of bcg, and levamisole on macrophage random migration, chemotaxis, and pinocytosis. | three parameters of macrophage function: random migration, chemotaxis, and pinocytosis, were studied in the guinea pig after administration of corynebacterium parvum, methanol-extraction residue of bcg, and levamisole (lms), a synthetic anthelmintic. macrophage migration studies were performed with a modified boyden chamber. pinocytosis was assessed by the uptake of colloidal 198au. after ip administration, each of the three immunostimulators induced an increase in macrophage chemotactic respons ... | 1977 | 864753 |
| [comparative study of the fractional protein composition of healthy and xanthomonas vesicatoria and corynebacterium michiganense infected tomato leaves]. | | 1977 | 865315 |
| [catalase isozyme spectrum of healthy tomato leaves and those inoculated with xanthomonas vesicatoria and corynebacterium michiganense]. | | 1977 | 865321 |
| inhibition of corynebacterium vaginale by metronidazole. | metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole], previously thought to only inhibit obligately anaerobic bacteria, was found in vitro, to inhibit the growth of 15 facultatively anaerobic strains of corynebacterium vaginale (haemophilus vaginalis) using agar disk diffusion and broth dilution methods. | 1977 | 867202 |
| the etiology of nongonococcal urethritis in men attending a venereal disease clinic. | nongonococcal urethritis was identified as a major reason that men attended our venereal disease clinic. the prevalence of several agents that might cause nongonococcal urethritis was determined. attempts were made to isolate gonococci; chlamydiae, ureaplasms urealyticum, trichmonads, candida sp., and corynebacterium vaginale from urethral swabs from 307 men. chlamydiae were recovered from 31% of the 67 men with nongonococcal urethritis compared to only 4% of 86 asymptomatic men without pyuria. ... | 1977 | 867205 |
| the inhibitory effect of corynebacterium parvum and pasteurella multocida pretreatment on staphylococcal synovitis in turkeys. | corynebacterium parvum and pasteurella multocida were shown to be immunostimulants in turkeys, increasing the ability of whole blood to kill staphylococcus aureus and prolonging the incubation time of experimental staphylococcal synovitis. | 1977 | 869828 |
| the distribution and persistence in vivo of corynebacterium parvum in relation to its antitumor activity. | killed corynebacterium parvum was labeled with fluorescein isothiocyanate or 125i, and both preparations were shown to retain lymphoreticular stimulatory and antitumor activity. large amounts of c. parvum injected i.v. were found in the liver, spleen, and lungs with less in bone marrow and lymph nodes. apart from a rapid loss from the lungs within 24 hr, the persistence of killed c. parvum was striking, and some intact bacteria were still detectable in the liver and spleen at 15 days. (by contra ... | 1977 | 870181 |
| antibody to corynebacterium parvum in normal human and animal sera. | using a microtiter bacterial agglutination test, we have estimated antibodies to corynebacterium parvum in "normal" human and "normal" and immune animal sera. widely differing levels of c. parvum antibodies were found in the normal human sera. the median titer for all 310 human sera was 1:128, whereas that for the 1- to 17-year and 18- to 50-year subgroups was 1:64 and 1:512, respectively. antibody titers in the various animal species were generally much lower. | 1977 | 870426 |
| localization and stability of hydrogenases from aerobic hydrogen bacteria. | alcaligenes eutrophus strains h 16, b 19, g 27 and n9a contained two different hydrogenases. one enzyme catalyzed the reduction of nad by hydrogen and was strictly localized in the soluble cell fraction. while the second enzyme was found to be particulate and unable to react with nad. all other tested strains, alcaligenes paradoxus sa 29, pseudomonas facilis, p. palleronii rh 2, pseudomonas sp. strain ga 3, paracoccus denitrificans, aquaspirillum autotrophicum sa 32, and corynebacterium autotrop ... | 1977 | 871226 |
| numerical taxonomy and ecology of oligotrophic bacteria isolated from the estuarine environment. | slow-growing bacteria, isolated on nutrient-rich and nutrient-limited media, from chesapeake bay water and sediment samples, were examined for 119 biochemical, cultural, morphological, nutritional, and physiological characters. those bacteria which grow on low nutrient media, termed oligotrophs, a total of 162 strains, were subjected to taxonomic analysis, as a preliminary step in determining their ecological significance. the data for all strains included in the study were examined by computer ... | 1977 | 871972 |
| comparative effect of anaerobic coryneforms on a murine melanoma. | ten strains of anaerobic corynebacteria were compared in their effect on survival of c57bl/6 mice, bearing subcutaneously inoculated b16 melanomas. the corynebacterial suspensions were injected intralesionally twice weekly for five injections. significant permanent tumor regression was not obtained. significant prolongation of survival was observed in mice treated with seven of the corynebacterial strains. | 1977 | 872039 |
| cell-mediated immunity and serum blocking factors in cancer patients during chemotherapy and immunotherapy. | the leukocyte adherence inhibition test was used to monitor tumor-specific cell-mediated immunity in 15 patients who had a variety of malignant tumors and were undergoing chemotherapy alone or in combination with immunotherapy by corynebacterium parvum. a rapid and prolonged loss of cell-mediated immunity in blood leukocytes was observed after treatment in all but one of the patients studied. abolition of reactivity was due to the lack of production of the soluble lymphokine-like factor affectin ... | 1977 | 872076 |
| immunological response in patients receiving corynebacterium parvum therapy. | | 1977 | 872468 |
| experimental model of corynebacterium renale pyelonephritis produced in mice. | corynebacterium renale type i (strain 115), 1.7 x 10(7) to 4.5 x 10(7) organisms, introduced intravenously into mice disappeared from the blood less than 24 h after inoculation and did not produce pyelonephritis. the same strain, 1 x 10(7) to 5 x 10(7) organisms, inoculated into the urinary bladder of mice was not recovered from the blood in any of the mice, but caused pyelonephritis accompanied by ureteritis and cystitis in 16 of 21 (76%) mice. pyelonephritis and cystitis in mice were histopath ... | 1977 | 873610 |
| corynebacterium genitalium (nonspecific urethritis corynebacteria). biologic reactions differentiating commensals of the urogenital tract from the pathogens responsible for urethritis. | | 1977 | 873733 |
| a practitioner's approach to mastitis therapy. | | 1977 | 873836 |
| corynebacterium parvum-induced radiosensitivity and cycling changes of hematopoietic spleen colony-forming units. | ten days after total-body irradiation with 550 rads of b0co, spleen colonies were observed in adult c57bl mice. a change in radiosensitivity induced by corynebacterium parvum, as measured by increased numbers of colony-forming units that survived the 550 rads, began shortly after c. parvum stimulation and extended for at least 7 days before irradiation. c. parvum given 4-24 hours before, followed by high specific activity [3h]thymidine (hsatt) 1 hour before total-body irradiation greatly reduced ... | 1977 | 875052 |
| the use of frozen, thawed erythrocytes in blood banking: a report of 28 months' experience in a large transfusion service. | a program of component therapy using largely frozen erythrocytes was initiated at cook county hospital in july 1973. use of the three existing washing systems for routine preparation of frozen erythrocytes has shown that there are differences in the levels of free hemoglobin, hematocrit, and residual glycerol in the washed products. adenosine triphosphate, 2,3-diphosphoglycerate, and extracellular potassium and sodium were found to be within acceptable limits. some expired units were cultured an ... | 1977 | 879099 |
| isolation of corynebacterium xerosis from clinical specimens: infection and colonization. | eleven patients were colonized or infected with diphtheroids identified as corynebacterium xerosis. all the patients were compromised hosts by nature of their underlying disease and/or therapy. two patients developed bacteremia following colonization of the respiratory tract with c. xerosis. other patients were colonized at various sites, which included the respiratory tract, abdominal and thoracic wounds, amputated limb, and arterial-venous shunt. distinctive features for the identification of ... | 1977 | 879104 |
| corynecin (chloramphenicol analogs) fermentation studies: selective production of corynecin i by corynebacterium hydrocarboclastus grown on acetate. | corynebacterium hydrocarboclastus ky 8835 grew in the acetate medium and accumulated 28mm corynecins which was the highest production yield among the processes using various carbon sources. selective production of corynecin i (over 90% of all corynecins), which had been desired for increase of the product yield, was achieved in this acetate medium. to keep the concentration of acetate, ammonium, and phosphate ions in the optimum range throughout the fermentation, a solution containing ch2cooh (5 ... | 1977 | 884230 |
| effect of corynebacterium liquefaciens on a c3hf mouse squamous cell carcinoma. | the antitumor effect of anaerobic corynebacterium liquefaciens was compared with that of specific immunization. experimental tumors were fourth or fifth generation isotransplants of a nr-sl squamous cell carcinoma that arose spontaneously in a c3hf/he female mouse. specific immunization failed to exhibit an antitumor effect, whereas a single administration of the bacterium markedly inhibited the growth of the tumor. this growth inhibition was most effective when c. liquefaciens was administered ... | 1977 | 884666 |
| host immunological mechanisms in the resistance of mice to leptospiral infections. | several serovars of leptospira virulent for hamsters and guinea pigs caused acute lethal leptospirosis in mice immunosuppressed with cyclophosphamide. neither bcg vaccine nor corynebacterium parvum suspension influenced the course of leptospiral infection in either immunosuppressed or normal balb/c mice. nude athymic mice produced anti-leptospiral antibody and were therefore resistant to infection with leptospires. nude mice were made susceptible with cyclophosphamide but were immune if they had ... | 1977 | 885617 |
| nephritis associated with a diphtheroid-infected cerebrospinal fluid shunt. | hypocomplementemic proliferative glomerulonephritis occurred during diphtheroid infection of a ventricular decompression shunt for cerebrospinal fluid diversion (cerebrospinal fluid shunt) in a young man. granular deposits of immunoglobulin m (igm) and the third component of complement (c3) were found along the glomerular basement membrane. this report provides supportive evidence for immune complex-mediated glomerular injury due to diphtheroid infection in a cerebrospinal fluid shunt. | 1977 | 888853 |
| emulsifying and surface active agents from corynebacterium hydrocarboclastus. | a corynebacterium hydrocarboclastus culture isolated in our laboratory (see, zajic and knettig, developments in industrial microbiology, 1971, p. 87) has been shown to produce an extracellular biopolymer with emulsifying properties when grown on a mixture of linear hydrocarbons. this microorganism was found to grow well on a variety of carbohydrates and hydrocarbons. however, the best substrates were pure linear hydrocarbons and particularly, n-c12, n-c13, and n-c14. the substrates supporting go ... | 1977 | 890082 |
| corynebacterium equi infection in a thoroughbred foal. | | 1977 | 891519 |
| comparative study of corynebacterium parvum and corynebacterium liquefaciens on antitumor activity against sarcoma-180. | corynebacterium parvum and corynebacterium liquefaciens were comparatively examined for their antitumor activity against sarcoma-180 in ddy mice. in the case of ascitic form, significant antitumor effect was observed when c. parvum was administered on days -4 and -2 or day -2. as for solid form, maximal effect was obtained when c. parvum was administered on day 0. on the other hand, c. liquefaciens exhibited maximal antitumor activity against sarcoma-180, both in ascitic and solid forms, when it ... | 1977 | 892298 |
| mechanisms of resistance to corynebacterium kutscheri in mice. | involvement of the mononuclear phagocyte system in the mechanism of resistance to corynebacterium kutscheri was studied in c57b1/6 and swiss lynch mice. a major difference between the two mouse strains was that the phagocytic cells of the livers of c57b1/6 mice destroyed the bacteria with much greater efficiency. there was no evidence of serum factors which might have led to this greater bacterial killing observed in the c57b1/6 mice, and in vivo phagocytosis of c. kutscheri was identical in bot ... | 1977 | 892907 |
| zeatin ribonucleosides in the transfer ribonucleic acid of rhizobium leguminosarum, agrobacterium tumefaciens, corynebacterium fascians, and erwinia amylovora. | until recently, the presence in transfer ribonucleic acid (trna) of the hydroxylated cytokinin ribosylzeatin [n6-(4-hydroxy-3-methylbut-2-enyl)adenosine]was thought to be unique to higher plants. this extension of work from several laboratories indicates the presence of 2-methylthioribosylzeatin in the trna of the plant-associated bacteria rhizobium leguminosarum, agrobacterium tumefaciens, and corynebacterium fascians, but not in that of erwinia amylovora. this cytokinin has the cis configurati ... | 1977 | 893341 |
| quantitative bacteriology of the vaginal flora. | quantitative bacteriology was performed on vaginal secretions from healthy adult women. the analysis included a single sample from 17 college students and 35 samples from five volunteers collected at intervals of three to five days throughout the menstrual cycle. mean concentrations in all 52 specimens were 10(8.1) aerobic bacteria/g and 10(9.1) anaerobic bacteria/g. the rank of predominant organisms, according to rates of recovery in concentrations of greater than 10(5) colony-forming units/g, ... | 1977 | 894079 |
| distribution of menaquinones in actinomycetes and corynebacteria. | menaquinones were the only isoprenoid quinones found in 48 corynebacteria and actinomycete strains examined. dihydromenaquinones having nine isoprene units were the main components isolated from gordona, mycobacterium, corynebacterium bovis, corynebacterium glutamicum and a strain labelled nocardia farcinica, but dihydromenaquinones having eight isoprene units were characteristic of other corynebacterium species and representatives of the 'rhodochrous' complex. tetrahydromenaquinones having six ... | 1977 | 894261 |
| effect of immunomodulators on effector cells involved in antibody-dependent cellular cytotoxicity: brief communication. | the effect of four immunomodulators (bcg, corynebacterium parvum, pyran copolymer, and levamisole) on the cellular arm of antibody-dependent cellular cytotoxicity (adcc) was investigated in mice with 51cr-labeled chicken erythrocytes employed as targets. all these drugs, except levamisole, stimulated the effector cells of adcc in the spleen, but the kinetics of their effect differed. stimulation of the effector cells of adcc peaked on day 15 after injection of bcg and c. parvum and on day 7 afte ... | 1977 | 894742 |
| vaginitis. reducing the number of refractory cases. | therapeutic failure in vaginitis can be minimized if all cases are properly diagnosed and specific therapy is given. use of wet mounts combined with liberal use of cultures, especially for corynebacterium vaginale, should result in an accurate diagnosis in over 90% of cases. treatment of choice for candidiasis is nystatin or miconazole nitrate applied topically. for trichomoniasis, metronidazole should be given orally to both sexual partners. ampicillin, cephalexin, or cephradine are recommended ... | 1977 | 896608 |
| combined radiotherapy and corynebacterium parvum treatment of a murine fibrosarcoma. | a single dose of corynebacterium parvum (cp) at 70 microgram, 175 microgram or 350 microgram was effective in suppressing the growth of a subcutaneous fibrosarcoma and occasionally in inducing complete regression and in prolonging the survival time of c3h/hej tumor-bearing mice. a single exposure of x rays at 2,000 rads induced some complete regression, but a higher number of complete regressions was induced by combined x-ray and cp treatment. in the combined x-ray and cp treatment, cp given on ... | 1977 | 897175 |
| ovine pneumonia caused by corynebacterium equi. | | 1977 | 898642 |
| [occurrence and etiology for subclinical mastitis in cows]. | studied were a total of 16,571 cows on 89 farms by means of the bernburg test. milk was sampled from the positively reacting quarters of the udder by taking 18,047 samples intended for bacteriologic investigation. the demonstration of mastitis streptococci was carried out on "tkt" agar merk, of pathogenic staphylococci, hemolytic streptococci, and corinebacteria--on dextrose agar oxoid containing 7.5% citrated calf blood. the isolated hemolytic streptococcus bacteria from the two nutrient media ... | 1977 | 898651 |
| [determination of the intensity of antimicrobial immunity in diphtheria during an acute experiment]. | the authors elaborated a method of determination of the antimicrobial immunity intensity in diphtheria in an acute experiment: guinea pigs were infected with a virulent culture of corynebacterium diphtheriae grown on agar with iron in a concentration depressing the toxinogenesis. a temporary absence of the toxin formation permitted to evaluate the antibacterial immunity except the antitoxic one. guinea pigs preimmunized with somatic corynebacterium diphtheriae antigen or an immune antimicrobial ... | 1977 | 899456 |
| [effect of corynebacterium parvum on various viral infections in the mouse]. | | 1977 | 900789 |
| local control and disease-free survival after treatment of a squamous cell carcinoma by corynebacterium parvum and local irradiation. | | 1977 | 908026 |
| efficacy of corynebacterium parvum treatment of mice with sarcoma growing in normal or irradiated tissue. | | 1977 | 908052 |
| brain damage by extracts of parasitised annual ryegrass (lolium rigidum) in nursling rats. | extracts of annual ryegrass (lolium rigidum) infected with anguina sp. and corynebacterium sp., and associated with an outbreak of annual ryegrass toxicity in sheep, were administered to 2-week-old rats by a single intraperitoneal injection. rats that received a lethal dose of toxin developed neurological signs including incoordination and convulsions from the second day and most died between 2 and 7 days after injection. histologically, the brains showed widespread lesions of focal necrosis con ... | 1977 | 911279 |
| increase of phagocytic activity and new appearance of a c4b (guinea pig) recognizing capability in peritoneal macrophages from corynebacterium parvum and thioglycollate-stimulated mice. | activated mouse macrophages displayed enhanced phagocytic activity towards particles opsonized with igg antibody and homologous c3. in addition, they were able to recognize guinea pig c4b. it is concluded that activated macrophages develop phagocytically active receptors for heterologous c4b. | 1977 | 917013 |
| investigations on prostatic adenocarcinomas in rats. | metastatic prostate adenocarcinomas, derived from aging germfree wistar rats, have been propagated in rats and in tissue culture. a protocol has been developed and demonstrated for assay of treatments which retard or which accelerate the rate and extent of tumor growth and of metastasis in tumor-bearing rats. the pattern of spread has been retarded by cyclophosphamide, aspirin, indomethacin, and corynebacterium parvum. the spread pattern has been accelerated by oral administrations of sodium bar ... | 1977 | 917442 |
| effects of corynebacterium parvum on tumour metastases in mice. | | 1977 | 922293 |
| expression of a new cell surface antigen on activated murine macrophages. | a macrophage cell-surface antigen associated with pyran and corynebacterium parvum-activated macrophages and p388d1 cells but not detectable on normal or glycogen and thioglycollate-elicited murine macrophages has been described. the antigen was demonstrated both by complement-mediated cytotoxicity and immunofluorescence, using an appropriately absorbed rabbit antiserum to p388d1. this antiserum should enable the characterization of activated macrophage cell populations on an individual cell bas ... | 1977 | 925608 |
| identification of producer and biological activities of new antibiotics, mimosamycin and chlorocarcins. | a strain of streptomyces, no. 314 identified as a streptomyces lavendulae produced under a novel condition of culture, four new antibiotics, mimosamycin and chlorocarcins a, b, and c. among the components of chlorocarcin complex, chlorocarcin a was found to be most biologically active. this antibiotic inhibited the growth of staphylococcus aureus fda 209p and corynebacterium diphtheriae at the concentrations of 0.1 and 0.003 mcg/ml, respectively. chlorocarcin a also exhibited antitumor activity ... | 1976 | 931810 |
| catabolism of l-tyrosine by the homoprotocatechuate pathway in gram-positive bacteria. | a metabolic pathway for l-tyrosine catabolism involves 3,4-dihydroxyphenylacetic acid (homoprotocatechuic acid) as substrate for fission of the benzene nucleus. cell extracts of an organism tentatively identified as a micrococcus possessed the enzymes required for degrading homoprotocatechuate to succinate and pyruvate, and stoichiometry was established for several of these reactions. when the required coenzymes were added, cell extracts degraded l-tyrosine to the ring-fission product of homopro ... | 1976 | 931949 |
| paradoxical effects of immunopotentiators on tumors and tumor viruses. | growth of tumors was inhibited or enhanced in mice by a synthetic (pyran) or a biologic (corynebacterium parvum) immunopotentiator. marked inhibition of leukemogenesis induced by friend leukemia virus was produced by prophylactic intraperitoneal treatment with pyran, while intravenous treatment with pyran (in the same dose and regimen) significantly enhanced growth of tumor virus. paradoxical effects were also seen with the biologic immunopotentiator c. parvum in solid tumor systems. treatment w ... | 1976 | 932503 |
| a diphtheria outbreak in dade county, florida. | during a 16-week period in late 1969, 11 cases of diphtheria (three fatal) were reported from miami, dade county, florida. for each of ten previous years, two cases at most had been reported. all patients resided in a predominantly black, low socioeconomic community within the 7-square-mile model city area. nine patients had positive cultures for toxigenic corynebacterium diphtheriae, mitis strain. none of the 11 patients or 22 culture-positive household contacts had been vaccinated against diph ... | 1976 | 935909 |
| tuberculosis in brood sows and pigs slaughtered in iowa. | mycobacterium avium was isolated from 21 of 23 lymph nodes with lesions collected from 23 brood sows and from 17 lymph nodes with lesions of 17 pigs slaughtered at an abattoir in north central iowa. mycobacterium avium serotype 2 accounted for more than 65% of the isolations in sows and in pigs. granulomas with acid-fast bacilli were found in 15 of 23 tissues from brood sows and in 13 of 17 lymph nodes from pigs. similar microscopic lesions were observed in the sows and pigs. | 1976 | 937801 |
| corynebacterium equi pneumonia in a patient with hodgkin's disease. | | 1976 | 937836 |
| an outbreak of diphtheria in boergoat kids. | during an outbreak of diphtheria or ulcerative stomatitis in young boergoat kids fusobacterium necrophorum was consistently isolated under anaerobic cultural conditions from material taken from the edges of the ulcerative lesions from all of the cases examined. corynebacterium pyogenes, staphylococcus aureus, actinobacillus lignieresi, moraxella spp. and lactobacillus spp. were also isolated anaerobically and/or aerobically. the typical symptoms and lesions were confirmed to the mouth, tongue an ... | 1976 | 940095 |
| bacterial catabolism of threonine. threonine degradation initiated by l-threonine-nad+ oxidoreductase. | 1. isolates representing seven bacterial genera capable of growth on l-threonine medium, and possessing high l-threonine 3-dehydrogenase activity, were examined to elucidate the catabolic route. 2. the results of growth, manometric and enzymic experiments indicated the catabolism of l-threonine by cleavage to acetyl-coa plus glycine, the glycine being further metabolized via l-serine to pyruvate, in all cases. no evidence was obtained of a role for aminoacetone in threonine catabolism or for the ... | 1976 | 942418 |
| bacteriologic aspects of epidural analgesia. | the incidence of contamination of catheters and syringes used during epidural analgesia for parturients and the effectiveness of bacterial filters were investigated. the effect of bupivacaine on bacterial viability and growth was also studied. syringes in 5/101 cases were contaminated, while catheter tips located in the epidural space were sterile. organisms isolated were skin commensals and probably originated on the hands of anesthetic personnel. bupivacaine (0.25%) was bacteriocidal to s epid ... | 1976 | 943977 |
| study of the mechanism of corynebacterium parvum anti-tumour activity. i. protective effect on the growth of two syngeneic tumours. | the protective effect of c. parvum against two different tumours - a lymphosarcoma and a mammary carcinoma - has been demonstrated. in the case of lymphosarcoma, a significant protective effect was obtained when both c. parvum and tumor cells were injected iv. in contrast in c3h mice the best protection was obtained when both c. parvum and mammary carcinoma cells were injected ip. thus both c. parvum and tumour cells must be inoculated by the same route which, however, varies for different tumou ... | 1976 | 946965 |
| observations following corynebacterium parvum administration to patients with advanced malignancy. a phase i study. | there has been increasing interest regarding the use of corynebacterium parvum (cp) with other modalities in the management of primary cancer. due to the paucity of specific information available relative to cp toxicity, a phase i study was carried out in patients with advanced disease. the purpose of the investigation was not to evaluate the effect of cp on tumor growth. from 273 injections of cp in 40 patients it was observed that following intravenous (i.v.) infusion of cp: a) a febrile respo ... | 1976 | 947509 |
| [lipids and lipases of mycobacteria and closely related microorganisms]. | | 1976 | 947971 |
| regression of a hamster melanoma with intralesional corynebacterium granulosum. | the present study was undertaken to compare the antitumour effects of intralesionally administered corynebacterium granulosum, corynebacterium parvum, bcg and saline on a hamster melanoma. forty-eight golden hamsters were inoculated subcutaneously with forthers melanotic melanoma no. 1. twenty-four animals bore palpable tumours which were excised. no non-excised group animal showed primary tumour regression. in the excised group, the tumours generally recurred at the excision site in the c. parv ... | 1976 | 949459 |
| radiation therapy and corynebacterium parvum in the treatment of murine tumors. | the relative effectiveness of local irradiation alone or combined with corynebacterium parvum (c parvum) treatment has been investigated employing four tumors: a mammary carcinoma (mca) (nonimmunogenic), a fibrosarcoma (moderately strongly immunogenic), and two squamous cell carcinomas (scc-2 being weakly and scc-4 being very weakly or nonimmunogenic). c parvum treatment was started when the isotransplanted tumor growing in the mouse leg was 5 mm in diameter and the local irradiation was adminis ... | 1976 | 949676 |
| skin flora maps: a tool in the study of cutaneous ecology. | we sampled 162 and 175 skin sites, respectively, of a patient with severe atopic dermatitis and of a healthy subject, and constructed maps of the two individuals depicting the density and distribution of aerobic cutaneous flora over the entire body. all isolates of micrococcaceae were biotyped. neither the density nor the kinds of microorganisms were homogeneously arrayed. instead, the separate types of flora were skewed in distribution, tended to segregate on large anatomical regions, and inhab ... | 1976 | 950492 |
| proceedings: local corynebacterium parvum therapy in early breast cancer. | | 1976 | 953485 |
| proceedings: the effect of corynebacterium parvum on a subcutaneous tumour. | | 1976 | 953487 |
| pulmonary botryomycoma. | a patient with a mobile mass of anaerobic organisms in the pulmonary parenchyma is presented. radiographically it resembled a fungous ball. this observed botryomycoma may be part of the spectrum of aspiration pneumonia. | 1976 | 954467 |
| bronchiectasis in yearling feedlot cattle. | thoughout all of 1974, we surveyed, for illnesses and deaths, about 407,000 yearling feedlot cattle. from the 3,943 dead cattle, 1,988 necropsies were made; of the cattle necropsied, 32 (1.6%) had bronchiectasis. in this disease, the permanently dilated small bronchi and bronchioles, located in ventral parts of the lungs, were filled with accumulations of exudate and microorganisms, including pasteurella hemolytica, pasteurella multocida, corynebacterium pyogenes, escherichia coli, salmonella an ... | 1976 | 956033 |
| vaginal flora in asymptomatic women. | four groups of 25 asymptomatic women--pregnant, premenopausal and taking oral contraceptives, premenopausal and not taking oral contraceptives, and postmenopausal--were studied for the presence in vaginal specimens of aerobic bacteria, anaerobic bacteria, fungi, mycoplasma, chlamydia, herpes simplex virus, mycobacteria, and trichomonas. no significant differences in microbial flora were found among the groups. | 1976 | 957791 |
| letter: origin of toxicity in parasitised annual ryegrass (lolium rigidum). | | 1976 | 962746 |
| [development of arenarin resistance in corynabacterium michiganense (e smith) jensen in vitro]. | | 1976 | 967049 |
| [corynebacterium pyogenes var. hominis infections]. | | 1976 | 967454 |
| sepsis with a new species of corynebacterium. | sepsis with a previously undescribed species of corynebacterium was documented in four patients. all patients had predisposing illness at the time of infection, three patients having leukemia in relapse and one having a porencephalic cyst and a ventriculoatrial shunt. the isolates from blood cultures had a characteristic metallic sheen when grown on blood agar. they were resistant to most antibiotics tested, including the penicillins, but were uniformly sensitive to vancomycin. common biochemica ... | 1976 | 970766 |
| mechanism of d-alanine production by corynebacterium fascians. | the amounts of extracellular d-alanine accumulated by corynebacterium fascians atcc 21950 in a medium containing glycerol as the sole carbon source is increased to almost 12 mg/ml by adding pyruvate to the medium. cell-free extracts of c. fascians were shown to possess both l-alanine dehydrogenase and alanine racemase activities. these results indicated that a mechanism exists that allows this microorganism to synthesize d-alanine from pyruvate. a study comparing the optical purity of the intrac ... | 1976 | 970932 |
| inherited resistance to corynebacterium kutscheri in mice. | an analysis of the factors responsible for inherited resistance to corynebacterium kutscheri was undertaken. various inbred mouse strains were examined; these included the swiss lynch and c57bl/l mice, their f1 and f2 progeny, and the progeny of the f1 backcrossed to each parent strain. two modes of inherited resistance are described. an examination suggested that resistance as measured by the mean lethal dose of c. kutscheri was under polygenic control and was inherited continuously. however, t ... | 1976 | 971958 |
| rapid method for the detection and identification of mycolic acids in aerobic actinomycetes and related bacteria. | a rapid method for the identification of lipids characteristic of the genera corynebacterium, mycobacterium, nocardia, and the "rhodochrous group" has been developed. modifications of previously described methods make this procedure suitable for use in the clinical laboratory. thin-layer chromatography is used to demonstrate the presence of the lipid characteristic of nocardia spp. (type a) in some corynebacteria, nocardias, and members of the "rhodochrous group." precipitation in ether and etha ... | 1976 | 972195 |
| immunological enhancement of leukemia l1210 by corynebacterium parvum in allogeneic mice. | the effect of corynebacterium parvum on the immune response of c57bl/6 mice (h-2b) to the allogeneic leukemia l1210 (h-2d) was investigated. mice were either left untreated or given c. parvum i.v. or i.p. in various dosages. seven days later they were challenged with 2.5 to 10 x 10(6) live l1210 cells i.p. control animals almost always rejected the challenge. in contrast, most mice pretreated with either 1.0, 0.5, or 0.25 mg of c. parvum i.v. and 1.0 or 0.5 mg i.p. exhibited enhanced growth of l ... | 1976 | 975053 |
| fetal maceration and suppurative metritis in a mule deer. | | 1976 | 977463 |
| mechanisms of antitumor action of corynebacterium parvum: the generation of cell-mediated tumor specific immunity. | | 1976 | 978659 |
| comparison of the potentiation of specific tumor immunity in mice by corynebacterium parvum or bcg. | two independent studies have compared killed c. parvum (cp) vaccine with viable bcg (pasteur) and bcg (glaxo) vaccines, respectively, for potentiation of antitumor immunity when injected with irradiated tumor cells into b6d2f1 and cba-t6t6 mice. both studies concurred that, for a given number of irradiated tumor cells, larger amounts (dry weight equivalent) of bcg than cp were required to produce similar degrees of tumor immunity. evidence also showed that stronger and more protracted immunity w ... | 1976 | 978769 |
| organisms associated with abortion and reproductive problems in cattle. | in 14 herds totaling over 2000 cattle the bacterial species most frequently isolated from the vagina, fetus, and fetal membranes following abortion or reproductive failure were streptococcus, corynebacterium, bacillus, and staphylococcus, less often e coli. about 5% of the total 1810 isolations included various other agents. although most of the aborted fetuses had undergone autolysis, pulmonary, hepatic, renal, and placental lesions were observed in a few cases. | 1976 | 979950 |
| a study of skin diseases in dogs and cats. ii. microflora of the normal skin of dogs and cats. | a study of the microflora of the normal skin was undertaken in 10 dogs and 10 cats. swabs were taken from the surface of the skin at 7 different sites (fig. 1). micrococcus spp., alpha-hemolytic streptococci, and acinetobacter spp. were found consistently in both species. staphylococcus aureus was isolated from 9 dogs and 4 cats, and staphylococcus epidermidis from 7 dogs and 5 cats. beta-hemolytic streptococci, corynebacterium spp., bacillus spp., escherichia coli, proteus mirabilis, pseudomona ... | 1976 | 980697 |
| prevalence of corynebacterium bovis in bovine milk samples. | | 1976 | 982768 |
| biotyping and serotyping of propionibacterium acnes strains isolated from different diagnostic materials. | fifty strains of propionibacterium acnes, five strains with the previous designation corynebacterium parvum and three strains of propionibacterium avidum were agglutinated by bacto-corynebacterium acnes 554 antiserum (difco); it was not possible to isolate any strain reacting only with 605 antiserum. only one strain of c. parvum reacted with both sera. 48 (88 per cent) out of 54 strains (p. acnes and c. parvum) belonged to voss' group i and 25 (47 per cent) belonged to pulverer's biotype a. str ... | 1976 | 983535 |
| corynebacterium vaginale (haemophilus vaginalis) in women with leukorrhea. | corynebacterium vaginale was recovered from vaginal-cervical swab specimens in 164 of 288 women with leukorrhea and in four of 30 women without signs or symptoms of lower genital tract infection. the amount and character of the leukorrhea observed in association with c. vaginale infection were variable; in typical cases the discharge had the appearance of a thin paste. in a series of 100 patients studied to determine the apparent causes of leukorrhea, noninfectious causes were inferred in seven ... | 1976 | 984128 |
| antimicrobiol susceptibility of propinibacterium acnes and related microbial species. | the minimal inhibitory concentrations of 32 antimicrobial agents were established for 73 strains of propionibacterium acnes and four related species (p. granulosum, p. avidum, corynebacterium minutissimum, and c. parvum). most strains showed good susceptibility to those agents usually considered active against gram-positive organisms. with the exception of c. minutissimum, the strains tested revealed more or less identical susceptibility ranges. the lowest minimal inhibitory concentrations were ... | 1976 | 984781 |
| bacteria within ovules and seeds. | surface-sterilized ovules and seeds of 27 species of plants were cultured in the water of syneresis of a nutrient medium low in agar content. bacteria were obtained from 30% of the ovules, 15% of the seeds of herbaceous plants, 16% of the seeds of woody plants, 5.4% of the overwintered noncereal seeds, and 13.5% of overwintered cereal seeds. in no instance did every ovule or seed of a plant species contain bacteria. no bacteria were obtained from the hard, waxy seeds of mimosa or yellowwood. the ... | 1976 | 984839 |
| bacterial flora in relation to cataract extraction. iv. postoperative inflammation. the role of conjunctival bacteria and certain surgical factors. | in 499 patients operated on for cataract, the clinical postoperative signs of extraocular inflammation (conjunctival hyperaemia, chemosis, discharge and oedema of the lids), the number of infiltrates around the corneoscleral sutures, and the severity of intraocular inflammation in the anterior chamber (aqueous-flare) were assessed on the fourth postoperative day and correlated with the bacterial conjunctival flora examined both qualitatively and quantitatively on the same day. patients with pote ... | 1976 | 988945 |
| the characteristics of binding of corynebacterium parvum to glass-adherent mouse peritoneal exudate cells. | corynebacterium parvum, strain 10390, whole organisms were shown to bind to the surface of glass-adherent mouse peritoneal exudate cells in vitro. an hcl extract and a lipid extract of the organism were both capable of inhibiting this binding. the attachment of organisms was not affected by trypsin treatment of the cells, indicating that the plasma membrane receptor is not cell-bound antibody in nature. the binding was inhibited by various sugars, most of which are major components of the cell w ... | 1976 | 991461 |
| deconjugation of bile acids by human intestinal bacteria. | the purpose of this report is to present the deconjugation of bile acids by numbers of strains of bacteria in the small intestine and feces. the small intestinal juice was aseptically aspirated by a double lumen tube with a rubber cover on the tip devised by us ("fukushima type 1"). bile acids were analyzed with thin layer chromatography. the results: 1) among aerobic bacteria, species of which all of the strains split conjugated bile acids was enterococcus, and most of the strains split were st ... | 1976 | 992250 |
| effects of corynebacterium parvum treatment and toxoplasma gondii infection on macrophage-mediated cytostasis of tumour target cells. | injection of mice with corynebacterium parvum or living or killed toxoplasma gondii was studied to determine the efficacy of these treatments in activating peritoneal macrophages to inhibit the uptake of [3h]tdr (cytostasis) by tumour target cells in vitro. in the presence of activated macrophages from mice treated i.p. with a wide dose range of either c. parvum or living toxoplasma, cytostasis was usually greater than 99%. this population of activated macrophages was transient in c. parvum-trea ... | 1976 | 992714 |
| concomitant immunity to pulmonary metastases of a murine fibrosarcoma: influence of removal of primary tumor by radiation or surgery, of active specific immunization and treatment with corynebacterium granulosum. | | 1976 | 993093 |
| bacteriology of the lower respiratory tract as determined by fiber-optic bronchoscopy and transtracheal aspiration. | for assessment of the validity of cultures of tracheobronchial secretions and exudates (tbse) obtained by fiber-optic bronchoscopy, the aerobic and anaerobic flora of expectorated saliva and tbse obtained by fiber-optic bronchoscopy from nine healthy volunteers and eight patients were compared with those obtained by fiber-optic bronchoscopy as well). normal volunteers yielded both aerobic and anaerobic bacteria in amounts usually less than 104.5 colony-forming units (cfu)/ml in tbse obtained by ... | 1976 | 993617 |
| caseous lymphadenitis in sheep -- methods of infection. | depending on the route of infection, experimental exposure of 30 sheep to corynebacterium pseudotuberculosis resulted in either mucopurulent vaginitis, prosthitis, conjunctivitis, rhinitis, or in subcutaneous abscessation. caseous lymphadenitis, from which the organism could be recovered in 52 out of 56 instances, occurred in every instance with the exception of animals infected by the preputial route. | 1976 | 994136 |
| experimental cancer immunotherapy: comparison of tumor rejection if f344 rats given live mycobacterium bovis (strain bcg) and killed corynebacterium parvum. | f344 rats received grafts of syngeneic 13762 mammary adenocarcinoma cells previously admixed with either living bcg of killed corynebacterium parvum administered sc or intradermally (id). animals given id transplants of tumor cells admixed with either bcg or killed c. parvum exhibited tumor growth for an average of 10 days, then regression in size and rejection of the tumor nodules. lesions were found in rats given sc transplants of tumor cells admixed with the killed microorganism for an averag ... | 1976 | 994209 |
| antitumor activity of killed corynebacterium parvum suspensions in a murine mammary adenocarcinoma cad2) system. | we studied the antitumor activity of killed corynebacterium parvum on the cad2 mammary adenocarcinoma in dba/2 mice. intratumor treatment had little or no effect on subcutaneous tumor growth. admixture of tumor cells with c. parvum before inoculation completely suppressed tumor growth. no tumor transplantation immunity was detected in mice inoculated with admixtures of c. parvum and tumor cells, but tumors were enhanced under certain circumstances. growth of a tumor inoculated sc or iv was consi ... | 1976 | 994219 |