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[spontaneous gas gangrene infection with clostridium septicum]. 201020401824
clostridium septicum empyema in an immunocompetent woman.we report a case of a clostridium septicum empyema in an immunocompetent woman following operation for an incarcerated internal hernia. the patient was successfully treated with pleural decortication and an extended course of postoperative antibiotics. this is the first report of such an infection in the medical literature.201020490275
septic arthritis and clostridium septicum: a clue to colon cancer. 201020513782
fulminant endogenous gas gangrene: role of ultrasonography in the emergency setting. 201020579573
a crackling priapism related to fournier's gangrene in a patient on chronic peritoneal dialysis. 201020600298
clostridial dermatitis and cellulitis: an emerging disease of turkeys.clostridial dermatitis of turkeys (cdt) has emerged as a major issue across most geographic regions of the united states. the prevalence and severity of dermatitis has increased over the last several years, since the time it was first reported in 1993. cellulitis in poultry can be associated with staphylococcus aureus or escherichia coli, but the more recent field situation in turkeys is specifically associated with clostridium spp. the prevalence of cellulitis is relatively low; however, the di ...201020608520
role of clostridium perfringens and clostridium septicum in causing turkey cellulitis.the role of clostridium perfringens and clostridium septicum in the development of cellulitis and mortality in turkey poults was examined. studies were done in turkeys of two age groups: 3-wk-old and 7-wk-old turkey poults. the effect of varying doses of c. perfringens and c. septicum in reproducing cellulitis lesions and mortality in turkeys was investigated. both in vitro and in vivo assays were conducted to study their toxic and biologic activities. clostridium septicum spore culture was foun ...201020608521
laetiporus sulphureus lectin and aerolysin protein family.the parasitic mushroom laetiporus sulphureus produces a family of lectins (lsl's) sharing 80-90% sequence identity that possesses a low but significant sequence similarity to the bacterial pore-forming toxins mosquitocidal toxin mtx-2 from bacillus sphaericus and a toxin from clostridium septicum. the crystal structure of one member of the l. sulphureus lectins family (lsla) reveals unexpected structural similarities to the 1-pore-forming toxins from the aerolysin family, namely, aerolysin from ...201020687481
an outbreak of gangrenous dermatitis in commercial broiler chickens.the present report describes an outbreak of gangrenous dermatitis (gd) infection in a commercial poultry farm in delaware involving 34-day-old broiler chickens. in addition to obvious clinical signs, some gd-affected broilers also showed severe fibrino-necrotic enteritis and large numbers of gram-positive rods in the necrotic tissue. histopathological findings included haemorrhage, degeneration and necrosis of parenchymatous cells, especially of skin, muscle, and intestine. immunofluorescence st ...201020706880
immunopathology and cytokine responses in commercial broiler chickens with gangrenous dermatitis.gangrenous dermatitis (gd) is an emerging disease of increasing economic importance in poultry resulting from infection by clostridium septicum and clostridium perfringens type a. lack of a reproducible disease model has been a major obstacle in understanding the immunopathology of gd. to gain better understanding of host-pathogen interactions in gd infection, we evaluated various immune parameters in two groups of birds from a recent commercial outbreak of gd, the first showing typical disease ...201020706881
septic arthritis and clostridium septicum: a clue to colon cancer. 201020855487
paraneoplastic clostridium septicum infection of a total knee arthroplasty.we describe a case of a well-functioning total knee arthroplasty acutely infected with clostridium septicum. this is the first reported infection of a prosthetic joint with this organism. a search for the source of this infection uncovered a colonic malignancy. this organism is highly associated with gastrointestinal malignancy, and appropriate investigation should be carried out when it is discovered. the importance of full anaerobic bacterial identification by the microbiology laboratory is un ...201020870378
[microbiological diagnosis of gas gangrene caused by clostridium septicum (a clinical case)].microscopy of gram-stained impression smears is used for the rapid diagnosis of microorganisms in the wound. the shin tissues of patient p. with suspected gas gangrene of lower extremity soft tissues were microscopically found to have gram-positive spore-forming bacteria that were morphologically similar to c. bifermentans that were identified as c. septicum on cultural diagnosis. the pathogenic c. septicum strain spores were likely to be formed in the macroorganism upon exposure of the pathogen ...201020886724
clostridium septicum myonecrosis presenting as an acute painful foot. 201021109383
development of a real time pcr taqman assay based on the tpi gene for simultaneous identification of clostridium chauvoei and clostridium septicum.in the present study, a taqman allelic discrimination assay based on three snps of the tpi gene is described. it was used as a differential diagnostic tool to detect blackleg and malignant edema. sudden deaths of grazing ruminants, such as cattle, sheep and goats, which show clinical signs related to hyperacute infective processes, encouraged the development of a rapid and precise diagnostic molecular method. specific primers and probes for clostridium septicum and clostridium chauvoei were desi ...201021182874
clostridium septicum causing sepsis with severe disseminated intravascular coagulation in a patient with crohn's disease. 201121212763
epsilon toxin: a fascinating pore-forming toxin.epsilon toxin (etx) is produced by strains of clostridium perfringens classified as type b or type d. etx belongs to the heptameric β-pore-forming toxins including aerolysin and clostridium septicum alpha toxin, which are characterized by the formation of a pore through the plasma membrane of eukaryotic cells consisting in a β-barrel of 14 amphipatic β strands. by contrast to aerolysin and c. septicum alpha toxin, etx is a much more potent toxin and is responsible for enterotoxemia in animals, m ...201121535407
emphysematous infectious aortitis: a dramatic evolution. 201121593042
abdominal aortic aneurysm repair complicated by infection with clostridium septicum. 201121620673
h1n1 vaccination: expect the unexpected. 201121646670
humoral immunity and injection-site reactions in cattle vaccinated with a multivalent clostridial vaccine administered via subcutaneous injection or via transdermal needle-free injection.objective-to evaluate injection-site reactions and serum antibody titers in cattle vaccinated with a clostridial vaccine administered sc or via needle-free transdermal injection. animals-sixteen 11-to 12-month-old herefords. procedures-cattle in 2 groups were vaccinated on days 0 and 28 with a commercially available multivalent clostridial vaccine administered sc or transdermally injection sites and serum antibody titers were evaluated at several time points after vaccination. serum antibody tit ...201121801072
clostridium septicum sepsis and colon carcinoma: report of 4 cases.an association exists between colon carcinoma and clostridium septicum infection, especially bacteremia. we reviewed retrospectively all positive blood cultures for this organism at a 300-bed general hospital over 4 years. four of 15 cases were associated with concurrent colon carcinoma. c. septicum infection was the presenting feature of previously undiagnosed large bowel malignancy in three patients. we report this small case series to alert clinicians to the diverse spectrum and diagnostic di ...201121747861
clostridium septicum post-endovascular aneurysm repair stent-graft infection.endovascular aortic aneurysm repair (evar) is establishing its role as a valid alternative for the treatment of abdominal aortic aneurysm. post-evar graft infection is a rare and devastating complication. the incidence of post-evar graft infection is yet to be defined, and available data at this stage consist of case reports and small series. possible etiologies for aortic stent-graft infection include perioperative contamination and hematogenous seeding. to the best of our knowledge, this is th ...201121715552
clostridium septicum myonecrosis: a destructive and lethal condition. 201121679616
A case of gas gangrene in an immunosuppressed Crohn's patient.Clostridium septicum (C. septicum) gas gangrene is well documented in the literature, typically in the setting of trauma or immunosuppression. In this paper, we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn's disease and sulfasalazine-induced neutropenia. The patient presented with left thigh pain, vomiting and diarrhea. Blood tests demonstrated a profound neutropenia, and magnetic resonance imaging of the thigh confirmed extensive myonecrosis. The patient u ...201121987630
a 2-year-old boy with hemolytic uremic syndrome and pneumocephalus.clostridium septicum infection following hemolytic uremic syndrome is rare and carries a poor prognosis, especially when the brain is involved. we report a case of a previously healthy 2-year-old boy who presented with two days of anuria and bloody diarrhea. he was admitted to the local children's hospital with a diagnosis of hemolytic uremic syndrome, presumably secondary to e. coli o157. he soon required intubation and was noted to have fixed and dilated pupils. head ct revealed left frontal s ...201222150928
simultaneous necrotizing soft tissue infection and colonic necrosis caused by clostridium septicum.abstract background: clostridial myonecrosis is an uncommon, highly lethal necrotizing soft tissue infection. the source may be occult at the time of clinical presentation. in cases caused by clostridium septicum, there is an association with colorectal malignant disease, suggesting that underlying colonic pathology frequently is the source of the infection. methods: case report and literature review. case report: a 37-year old man with acquired immunodeficiency syndrome, end-stage renal d ...201122142321
[mycotic aortic aneurysm infected by clostridium septicum: a case report and review of the literature].we report on a case of clostridium septicum aortic mycotic aneurysm in an 83-year-old patient. this is a rare infectious disease. to our knowledge, only 31 cases have been reported in the literature. the clinical presentation is dominated by abdominal pain with fever. although only the bacteriological samples can definitely identify the germ, the presence of gas bubbles around an aneurysm on abdominal computed tomography scan suggests c. septicum aortic infection. this infectious disease is freq ...201122014579
Life-threatening clostridial infections.Life-threatening soft tissue infections caused by Clostridium species have been described in the medical literature for hundreds of years largely because of their fulminant nature, distinctive clinical presentations and complex management issues. The Clostridium species perfringens, septicum and histolyticum are the principal causes of trauma-associated gas gangrene and their incidence increases dramatically in times of war, hurricanes, earthquakes and other mass casualty conditions. Recently, t ...201122120198
fatal neutropenic enterocolitis due to clostridium septicum.we describe a case of clostridium septicum enterocolitis in a patient with pre-b acute lymphoblastic leukaemia undergoing autologous stem cell transplant. in the setting of neutropenia, clostridium septicum should be suspected in patients who develop signs and symptoms of acute abdomen.201122519241
an unusual case of pneumocephalus.the authors present an unusual cause of pneumocephalus in a previously fit and well female octogenarian who presented with acute onset altered level of consciousness and generalised weakness. radiological imaging demonstrated widespread cerebritis with pneumocephalus and gas within the superior sagittal sinus. blood culture grew clostridium septicum, a virulent but rare organism that can infect normal tissues. the close association between c septicum and both haematological and bowel malignancie ...201122673713
genome-wide differential gene expression profiles in broiler chickens with gangrenous dermatitis.gangrenous dermatitis (gd) is a disease of poultry characterized by necrosis of the skin and severe cellulitis of the subcutaneous tissues caused by infection with clostridium septicum (cs) and/or clostridium perfringens (cp) type a. while gd causes significant morbidity, mortality, and economic loss to the poultry industry, the fundamental mechanisms underlying this host-pathogen interaction are relatively unknown. this study used comparative global gene expression microarray analysis of gd-aff ...201223397837
ischaemic stroke and clostridium septicum sepsis and meningitis in a patient with occult colon carcinoma - a case report and review of the literature.clostridium septicum is a rare cause of meningitis and brain abscess in children and adults. gas production by the pathogen can lead to pneumocephalus and the overall mortality rate of clostridium septicum cns infection is as high as 74%. the most common entry site of the pathogen is the gastrointestinal tract.201627881097
gut microbiota imbalance and colorectal cancer.the gut microbiota acts as a real organ. the symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. however, alterations to the microbiome caused by environmental changes (e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of ...201626811603
prebiotic effects of diet supplemented with the cultivated red seaweed chondrus crispus or with fructo-oligo-saccharide on host immunity, colonic microbiota and gut microbial metabolites.gastrointestinal microbial communities are diverse and are composed of both beneficial and pathogenic groups. prebiotics, such as digestion-resistant fibers, influence the composition of gut microbiota, and can contribute to the improvement of host health. the red seaweed chondrus crispus is rich in dietary fiber and oligosaccharides, however its prebiotic potential has not been studied to date.201526271359
fate of clostridium botulinum and incidence of pathogenic clostridia in biogas processes.this study aimed to assess the sanitary situation in agricultural biogas plants (bp) regarding pathogenic clostridium spp.201526198084
fatal spontaneous clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression.the long-term use of proton pump inhibitors has been linked to an increased risk for the development of gastric polyps, hip fractures, pneumonia, and clostridium difficile colitis. there is evidence that chronic acid suppression from long-term use of proton pump inhibitors poses some risk for the development of c difficile-associated diarrhea by decreasing the elimination of pathogenic microbes before reaching the lower gastrointestinal tract. here we present a case of a 51-year-old woman with a ...201424878026
development of clostridium septicum gas gangrene as an adverse effect of clindamycin-induced clostridium difficile infection in a pediatric patient.clostridium myonecrosis or gas gangrene is a life-threatening infection characterized by either traumatic or atraumatic etiology. it has been widely described in patients with traumatic open wounds and in immunocompromised patients, including malignancy. a third source can result from natural flora in the gastrointestinal tract after bowel ischemia. this is a rare occurrence and is even less commonly described in the pediatric population. we present a pediatric patient who developed clostridium ...201424590337
clostridium septicum gas gangrene in a previously healthy 8-year-old female with survival.we present the only reported case of an immunocompetent pediatric patient in the literature to have fulminate gas gangrene of the lower extremity and concomitant gastrointestinal tract infection due to clostridium septicum coinfected with clostridium difficile colitis respectively. the patient survived with aggressive medical and surgical treatment.201323583163
myonecrosis by clostridium septicum in a dog, diagnosed by a new multiplex-pcr.clostridial myositis is an acute, generally fatal toxemia that is considered to be rare in pet animals. the present report describes an unusual canine clostridial myositis that was diagnosed by a new multiplex-pcr (mpcr) designed for simultaneous identification of clostridium sordellii, clostridium septicum, clostridium perfringens type a, clostridium chauvoei, and clostridium novyi type a. a ten-month-old male rottweiler dog, that had displayed lameness and swelling of the left limb for 12 h, w ...201222975141
effects of dexamethasone immunosuppression on turkey clostridial dermatitis.clostridia represents a group of anaerobic spore-forming bacteria ubiquitous in the poultry environment. they are widely distributed in soil and survive for many years as highly resistant, inactive spores. they enter the body through wounds and contaminated feed as active bacteria or spores. multiplication of clostridial bacteria occurs only in the absence of oxygen or in environments with very low concentrations of oxygen. during active multiplication, the clostridial organisms produce several ...201425518439
opioid analgesics stop the development of clostridial gas gangrene.gas gangrene is a potentially fatal disease that is primarily caused by the ubiquitous, anaerobic bacteria clostridium perfringens and clostridium septicum. treatment is limited to antibiotic therapy, debridement of the infected tissue, and, in severe cases, amputation. the need for new treatment approaches is compelling. opioid-based analgesics such as buprenorphine and morphine also have immunomodulatory properties, usually leading to faster disease progression. however, here we show that mice ...201424550443
observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking eu(3+)-doped oxide nanoparticles.we track single toxin receptors on the apical cell membrane of mdck cells with eu-doped oxide nanoparticles coupled to two toxins of the pore-forming toxin family: α-toxin of clostridium septicum and ε-toxin of clostridium perfringens. these nonblinking and photostable labels do not perturb the motion of the toxin receptors and yield long uninterrupted trajectories with mean localization precision of 30 nm for acquisition times of 51.3 ms. we were thus able to study the toxin-cell interaction at ...201222677383
antibiotic prophylaxis of experimental clostridial infections. ii. penicillin prophylaxis of clostridium perfringens and clostridium septicum infections. 195224542145
colorectal neoplasm in cases of clostridium septicum and streptococcus gallolyticus subsp. gallolyticus bacteraemia.bacteremia with clostridium septicum (cs) and streptococcus gallolyticus subsp. gallolyticus (sgg) have both been associated with colorectal neoplasms (crn) and colonoscopic examination is advised, however the differences and similarities in colorectal findings are not well known.201728236516
hemolytic uremic syndrome complicated by clostridium septicum bacteremia and new-onset type 1 diabetes mellitus. report of a case
.we report the unusual case of a 5-year-old male hospitalized for management of diabetic ketoacidosis (dka) and new-onset type 1 diabetes mellitus (t1dm) who developed acute renal injury secondary to hemolytic uremic syndrome (hus). he was diagnosed with shiga toxin-producing entero-hemorrhagic <i>escherichia coli</i> (ehec) 0157:h7-positive hus 48 hours after being diagnosed with new-onset t1dm/dka. his hospital course was complicated by <i>clostridium septicum</i> sepsis with colonic perforatio ...201728211788
c septicum complicating hemolytic uremic syndrome: survival without surgical intervention.clostridium septicum is an anaerobic bacterium that causes rapidly progressive myonecrosis, bacteremia, and central nervous system infection. it has been reported as a complication of escherichia coli hemolytic uremic syndrome (hus) in 8 children worldwide; 5 children died, and the 3 reported survivors had surgically treated disease. we present 3 cases of c septicum complicating hus in children, including the first 2 reported cases of survival without surgical intervention. all patients presente ...201728183731
clostridial paraproctitis with gas gangrene of front-lateral abdominal walls and necrotic fascio-myositis (case report).anaerobic clostridial infection is the most severe form of paraproctitis. the incubation period is very short, from 3 to 6 hours, sometimes lasting for 1-2 days. clostridial infection spreads rapidly and induces gas gangrene, causes destruction of cells and other intermediate substances, and impedes blood circulation. this paper presents a case study of an extremely severe form of anaerobic infection with spontaneous gas gangrene, cellulitis, fasciomyositic necrosis, severe intoxication and sept ...201627770534
clostridium septicum: an unusual link to a lower gastrointestinal bleed.clostridium septicum is a highly virulent pathogen which is associated with colorectal malignancy, hematological malignancy, immunosuppression, diabetes mellitus and cyclical neutropenia. presentation may include disseminated clostridial infection in the form of septicemia, gas gangrene, and mycotic aortic aneurysms. we report the case of a 62-year-old female presenting with necrotizing fasciitis of her left thigh and subsequently developing rectal bleeding. while she was being treated with empi ...201727721737
complete genome sequence of clostridium septicum strain csur p1044, isolated from the human gut microbiota.clostridium septicum is one of the first pathogenic anaerobes to be identified. here, we announce the genome draft sequence of c. septicum strain csur p1044 isolated from the gut of a healthy adult. its chromosome genome consists of 3.2 mbp with a plasmid of 32 kbp. c. septicum strain csur p1044 has a g+c content of 27.5%, and is composed of 3,125 protein-coding genes together with 103 rna genes, including 22 rrna genes.201627609912
massive gas gangrene secondary to occult colon carcinoma.gas gangrene is a rare but often fatal soft-tissue infection. because it is uncommon and the classic symptom of crepitus does not appear until the infection is advanced, prompt diagnosis requires a high index of suspicion. we present a case report of a middle-aged man who presented with acute onset lower-extremity pain that was initially thought to be due to deep vein thrombosis. after undergoing workup for pulmonary embolism, he was found to have massive gas gangrene of the lower extremity seco ...201627257452
infections in the non-transplanted immunocompromised host.discoveries regarding the basic mechanisms underlying malignant disease, rheumatologic disorders, and autoimmune diseases have led to the development of many new therapeutic modalities that target components of the immune system. most of these are antibodies or fusion proteins that interfere with components of the immune response that are playing both pathological and protective roles, resulting in variable degrees of immune suppression and a higher risk of infectious complications.201627206239
clostridium septicum arthritis and aortitis in a patient with underlying colon cancer. 201626803153
clostridium septicum gas gangrene in colon cancer: importance of early diagnosis.the clostridia species are responsible for some of the deadliest diseases including gas gangrene, tetanus, and botulism. clostridium septicum is a rare subgroup known to cause atraumatic myonecrosis and is associated with colonic malignancy or immunosuppression. it is a gram-positive, anaerobic, spore-forming bacillus found in the gastrointestinal tract and can lead to direct, spontaneous infections of the bowel and peritoneal cavity. the anaerobic glycolysis of the tumor produces an acidic, hyp ...201526793397
clostridium septicum aortitis and colon carcinoma.clostridium septicum (c. septicum) aortitis is a rare but highly fatal infection that has a strong association with occult malignancy. aneurysmal transformation of c. septicum aortitis is common and has been reported to occur in as little as 1 to 3 weeks. we report a case of c. septicum aortitis with concomitant adenocarcinoma of the ascending colon detected via ct scan. imaging findings of colonic malignancy with aortitis are highly suggestive of infection with c. septicum. given the high assoc ...201626792077
clostridium septicum aortitis of the infrarenal abdominal aorta.clostridium septicum aortitis is a rare infection that has a strong association with occult colonic malignancy. there is also emerging evidence to support the combination of medical and surgical management over medical management alone. to the best of our knowledge, we report the 40th known case of c. septicum aortitis.201626767087
clostridium septicum pneumocephalus.spontaneous pneumocephalus in the nontraumatic setting is distinctly unusual. pneumocephalus from central nervous system infection with clostridium septicum has been rarely reported, and more commonly reflects a later stage of abscess formation. we present an unusual case of invasive c. septicum infection without an associated diagnosed malignancy presenting with rapidly progressive cns pathology and resultant early pneumocephalus.201626399246
an atypical presentation of colonic malignancy: clostridium septicum aortitis.clostridium septicum (cs) is a rare organism that accounts for only 1.3% of all clostridial infections. however, its detection is of great clinical significance, as over 80% of cases are associated with malignancy, often occult; the most common primary sites are the ascending colon and caecum, and the most common cause is haematological malignancy. we report a case of a 79-year-old woman, admitted with shortness of breath and left-sided chest pain, who, following subsequent investigations, was f ...201526374774
a case of clostridium septicum aortitis with concomitant adenocarcinoma of the cecum.clostridium septicum aortitis is a rare infection that is strongly associated with underlying adenocarcinoma of the colon. we report a case of a 73-year-old woman with peripheral vascular disease who presented after 4 weeks of severe abdominal pain. abdominal computed tomography showed thickening of the cecal wall and gas in the aortic wall. colonoscopy revealed a large ulcerated moderately differentiated adenocarcinoma in the cecum. blood cultures grew clostridium septicum. the patient was offe ...201526203448
the pore-forming α-toxin from clostridium septicum activates the mapk pathway in a ras-c-raf-dependent and independent manner.clostridium septicum is the causative agent of atraumatic gas gangrene, with α-toxin, an extracellular pore-forming toxin, essential for disease. how c. septicum modulates the host's innate immune response is poorly defined, although α-toxin-intoxicated muscle cells undergo cellular oncosis, characterised by mitochondrial dysfunction and release of reactive oxygen species. nonetheless, the signalling events that occur prior to the initiation of oncosis are poorly characterised. our aims were to ...201525675415
a noncytolytic α toxin recombinant protein protects turkeys against clostridium septicum challenge.clostridium septicum and its associated cytolytic α toxin, along with several other clostridial species, has been implicated as the causative agent of gangrenous dermatitis. a recombinant noncytolytic c. septicum α toxin (ncat) peptide was developed for use as a vaccine and demonstrated to be safe at concentrations as high as 1 mg/ml. ncat, used as a purified antigen, partially purified antigen, or in combination with native antigens, was compared to salt-fractionated α toxin combined with denat ...201425619001
foot infection by clostridium sordellii: case report and review of 15 cases in france.we report a case of foot infection by clostridium sordellii and review 15 human infections registered at a reference center in france during the period 1998 to 2011. all strains were found nontoxigenic, lacking the lethal toxin gene coding for tcsl. like clostridium septicum, several c. sordellii infections were associated with intestinal neoplasms.201525609723
low prevalence of clostridium septicum fecal carriage in an adult population.clostridium septicum is an uncommon cause of severe infection. real-time pcr against the c. septicum-specific alpha-toxin gene (csa) was used to estimate the prevalence of this microbe in human stool from 161 asymptomatic community-dwelling adults and 192 hospitalized patients with diarrhea. all samples were negative, suggesting a low prevalence.201525481351
mycotic thoracic aortic arch aneurysm from haematogenous spread of clostridium septicum due to metastatic colorectal cancer: a survival guide.we report the case of a 78-year-old female who was found to have a mycotic thoracic aortic arch aneurysm caused by clostridium septicum. subsequent investigations demonstrated adenocarcinoma of the caecum with two liver metastases. the patient underwent a hybrid procedure involving endovascular repair of the aneurysm with a right-to-left carotid crossover bypass and a left carotid to left subclavian bypass to protect the cerebral and left subclavian blood flow. the caecal tumour was later comple ...201425362731
fatal clostridium septicum myonecrosis in a captive canada lynx (lynx canadensis).a 1-yr-old female canada lynx (lynx canadensis) presented for sudden onset of rapidly progressive bilateral pelvic limb paralysis. the lynx was chemically immobilized to perform a physical examination but expired shortly thereafter. on postmortem radiographs, there were myriad small irregular, round-to-spherical gas densities within the skeletal muscle of the right thigh and epaxial musculature. at gross necropsy, the muscles of the right thigh, right lateral abdominal wall, and epaxial region w ...201425314833
identification of clostridium septicum in a tubo-ovarian abscess: a rare case and review of the literature.tubo-ovarian abscess (toa) is a conglomerated mass of pelvic organs including the tube, the ovary, and the bowel. the most commonly isolated organisms from toas are escherichia coli (e. coli) and bacteroides species.201425282789
a rare case of clostridium septicum mycotic aortic arch aneurysm following open right hemicolectomy for colorectal cancer. 201425260426
acute aortic dissection caused by clostridium septicum aortitis.clostridium septicum aortitis is a rare cause of aortic dissection. so far, only 28 cases have been described in literature before. most of these cases occurred in elderly patients and an association to colonic neoplasms and/or atherosclerosis has been witnessed frequently. here we report the case of a 32-year-old man with fatal aortic dissection due to aortic infection with c. septicum. beside a case of a 22-year-old man who died of aortic dissection due to c. septicum aortitis this is the seco ...201425242573
clostridium septicum endophalmitis associated with colon adenocarcinoma.endogenous clostridium septicum endophthalmitis is a rare, devastating infection that has been shown to be associated with colonic and hematologic malignancies. we present a case of clostridial endophthalmitis that resulted in expedient identification of colon adenocarcinoma.201427843415
necrotizing gastritis associated with clostridium septicum in a rabbit.clostridium septicum is the causative agent of histotoxic infections, including malignant edema and braxy (necrotizing abomasitis) in several animal species. the carcass of a 2-year-old, female new zealand white rabbit with a history of acute depression and obtundation followed by death was received at the california animal health and food safety laboratory system (san bernardino, california) for necropsy and diagnostic workup. no gross lesions were detected at necropsy. microscopically, there w ...201425164682
[infections due to unusual bacteria and bacterial oncogenesis].the recovery of an unusual organism in the clinical microbiology laboratory may be an indicator of an immunological abnormality in the patient. for instance, an important relationship between clostridium septicum and colon carcinoma as well as between leukemia or lymphoma with species frequently considered contaminants (bacillus spp., corynebacterium spp.) or others rarely isolated from different contexts (capnocytophaga spp.) were described. some bacteria are almost exclusively isolated from ai ...201425113721
necrotizing fasciitis and toxic shock syndrome from clostridium septicum following a term cesarean delivery.necrotizing fasciitis and toxic shock syndrome are life-threatening conditions that can be seen after any surgical procedure. with only 4 previous published case reports in the obstetrics and gynecology literature of these two conditions occurring secondary to clostridium septicum, we describe a case of necrotizing fasciitis and toxic shock syndrome occurring after a term cesarean delivery caused by this microorganism, requiring aggressive medical and surgical intervention.201424822140
gas gangrene presenting with back pain.a 61-year-old caucasian man (previously fit and well) presented to the emergency department with 2 days of non-traumatic, non-radiating lower back pain. he was admitted to our department having been provisionally diagnosed with discitis. later that night, while being reassessed, a skin lesion on his thigh appeared and gas could be palpated. the patient was then taken immediately to theatre and a radical surgical debridement was performed. the organism that grew from tissue samples was clostridiu ...201424811103
perianeurysmal emphysema: clostridium septicum-infected aortic aneurysm. 201424799507
vaccination of turkeys with clostridium septicum bacterin-toxoid: evaluation of protection against clostridial dermatitis.clostridial dermatitis is an acute disease causing high mortality in turkeys. both clostridium septicum and clostridium pefringens have been isolated from these cases; however, reports from several diagnostic laboratories indicate an increased isolation rate of c septicum compared with c. perfringens from cases of clostridial dermatitis in recent years. previous studies suggested c. septicum was more potent than c. perfringens in causing clostridial dermatitis in turkeys. the objective of this s ...201324689176
fatal clostridium septicum infection in a patient with a hematological malignancy.a 49-year-old woman with acute myeloid transformation of myelodysplastic syndrome was admitted with mild erythema and pain in the right thigh and left forearm. she was doing well and had been discharged the previous day after consolidation chemotherapy. examination showed only mild erythema and tenderness of the right thigh. she was started on broad-spectrum antibiotics. discoloration progressed rapidly, and within hours the right femoral and left brachial pulses were not palpable. she was taken ...201424688190
elevated levels of glycosylphosphatidylinositol (gpi) anchored proteins in plasma from human cancers detected by c. septicum alpha toxin.the glycosylphosphatidylinositol (gpi) anchor is a glycan and lipid posttranslational modification added to proteins in the endoplasmic reticulum. certain enzymes within the gpi biosynthetic pathway, particularly the subunits of the gpi transamidase, are elevated in various human cancers. specific gpi anchored proteins, such as carcinoembryonic antigen and mesothelin, have been described as potential biomarkers for certain cancers; however, the overall levels of gpi anchored proteins present in ...201424643042
genome-wide recessive genetic screening in mammalian cells with a lentiviral crispr-guide rna library.identification of genes influencing a phenotype of interest is frequently achieved through genetic screening by rna interference (rnai) or knockouts. however, rnai may only achieve partial depletion of gene activity, and knockout-based screens are difficult in diploid mammalian cells. here we took advantage of the efficiency and high throughput of genome editing based on type ii, clustered, regularly interspaced, short palindromic repeats (crispr)-crispr-associated (cas) systems to introduce gen ...201424535568
colorectal cancer liver metastasis presenting as pneumoperitoneum: case report and literature review.pneumoperitoneum presenting as air under diaphragm on erect chest x-ray is usually a result of hollow viscous perforation but can be a result of many other diagnoses including necrotising enterocolitis and ruptured liver abscess. we report a case of colon cancer with liver metastases presenting as pneumoperitoneum. this was a result of infection of the metastases with clostridium septicum with resultant rupture in to sub diaphragmatic space.201324426586
clostridium septicum brain abscesses in a premature neonate.brain abscesses in neonates are typically caused by gram-negative organisms. there are no previously described cases caused by clostridium septicum. we present a case of a premature male infant who developed recurrent episodes of suspected necrotizing enterocolitis followed by brain abscesses, cerebritis and ventriculitis caused by c. septicum.201424220230
foudroyant course of an extensive clostridium septicum gas gangrene in a diabetic patient with occult carcinoma of the colon.background. spontaneous gas gangrene is a rare disease in which clostridium septicum frequently can be detected. after an incubation period of 5-48 hours, a very painful swelling is accompanied by a rapidly spreading toxic-infectious clinical picture ultimately leading to septic shock and multiple organ failure. we present a case of a completely documented rare infectious disease with triage findings including initial vital signs, initial medical findings, and the emergency lab., radiological, i ...201323864974
fatal clostridium septicum following medical termination of pregnancy. 201323815218
necrotizing endometritis and isolation of an alpha-toxin producing strain of clostridium septicum in a wild sooty mangabey from côte d'ivoire.few lethal pathogens in wild-living primates have been described, and little is known about infectious diseases of the reproductive tract and their possible impact on health and reproduction. this report describes the pathology and isolation of an alpha-toxin producing strain of clostridium septicum in a case of necrotizing endometritis in a wild sooty mangabey found dead in a tropical rainforest of west africa.201323617545
clostridium septicum can cause distant myonecrosis in patients with ovarian cancer.a case report of lethal distant myonecrosis with gas gangrene is presented. blood cultures and tissue biopsies revealed clostridium septicum. the 55-year-old female patient presented with recurrent ovarian cancer of transitional cell type, initially diagnosed as figo iib in january 2011, with hepatic metastasis and invasion of the ceacal wall. she underwent several operations, including partial bowel and liver resection in september 2011. second-line therapy with topotecan three weekly was start ...201323564801
analysis of tryptophan-rich region in clostridium septicum alpha-toxin involved with binding to glycosylphosphatidylinositol-anchored proteins.clostridium septicum alpha-toxin has a unique tryptophan-rich region ((302)ngysewdwkwv(312)) that consists of 11 amino acid residues near the c-terminus. using mutant toxins, the contribution of individual amino acids in the tryptophan-rich region to cytotoxicity and binding to glycosylphosphatidylinositol (gpi)-anchored proteins was examined. for retention of maximum cytotoxic activity, w307 and w311 are essential residues and residue 309 has to be hydrophobic and possess an aromatic side chain ...201323278518
clostridium septicum gas gangrene in the orbit: a case report.our report presents a case of clostridium septicum gas gangrene in an unusual, orbital localization. the predisposing factors are typical: colon tumour and lymphatic malignancy. most probably bacteria from the intestinal flora entered the bloodstream through the compromised intestinal wall and settled in the orbit resulting in the development of an abscess containing gas. at the site of the gas gangrene, an indolent b cell lymphoma was present. after surgery and antibiotic treatment, the patient ...201323203898
clostridium septicum growth from a total knee arthroplasty associated with intestinal malignancy: a case report.previous reports of infection with clostridium septicum have identified an unexpected association with concurrent malignancy. the reported rate of associated malignancy has been found to be as high as 81 percent. the purpose of this case report was to present a case of a total knee arthroplasty infected with c. septicum and the subsequent finding of an occult colonic malignancy.201223031261
clostridium septicum sepsis and its implications.an elderly gentleman, who had 12 years earlier been successfully treated for colon cancer, presented with fever, rigours, right upper quadrant abdominal pain and tenderness. a ct of the abdomen revealed a colonic mass distal to the hepatic flexure with multiple gas locules and a walled off perforation. he underwent a right hemicolectomy. histology confirmed multifocal colonic adenocarcinoma. his admission blood cultures grew clostridium septicum. a week postoperatively he developed intermittent ...201222962388
a microbiological hazard of rural living: clostridium septicum brain abscess in a child with e coli 0157 associated haemolytic uraemic syndrome.clostridium septicum infection in humans is rare and this is the second case report of focal c septicum brain abscesses associated with escherichia coli 0157 haemolytic uraemic syndrome (hus). the case presented in a child who lived on a rural farm. the abscesses initially progressed despite 7&emsp14;months of appropriate antibiotic therapy and repeated image-guided aspiration. after definitive resection and prolonged antibiotic therapy, there was no recurrence. this case reminds us of this rare ...201222736786
clostridium septicum infection in a young pregnant patient.this report describes a young pregnant woman who presented to a rural emergency department with vaginal bleeding at 7 weeks of gestation. initially, the patient was stable; however, within 8 h the patient deteriorated into fulminant septic shock. she required aggressive resuscitation and surgical management of a septic abortion. the patient's condition improved rapidly following surgical evacuation of the uterus with dilatation and curettage. she has had no long-term sequelae. blood and tissue c ...201222675151
medical cause of compartment syndrome: a fatal case of clostridium septicum.a 57-year-old woman with non-hodgkin's lymphoma presented to the emergency department with febrile neutropaenia. she complained of fever and malaise and had a normal physical examination. ten hours later, she developed worsening right leg pain that required escalating doses of morphine. her physical examination remained unremarkable. owing to the increasing pain in her leg, an x-ray was performed which revealed subcutaneous emphysema. she subsequently developed numbness over her right leg and, t ...201222669929
proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma.the glycosylphosphatidylinositol (gpi) anchor is a lipid and glycan modification added to the c terminus of certain proteins in the endoplasmic reticulum by the activity of a multiple subunit enzyme complex known as the gpi transamidase (gpit). several subunits of gpit have increased expression levels in breast carcinoma. in an effort to identify gpi-anchored proteins and understand the possible role of these proteins in breast cancer progression, we employed a combination of strategies. first, ...201222654114
clostridium septicum aortitis in a patient with extensive atheromatous disease of the aorta.a 69-year man presented with 3 days of progressively worsening abdominal pain, radiating to his back, with nausea and vomiting. computed tomography scan of the abdomen showed evidence of aortitis, for which he eventually underwent surgery. the surgical specimen of the aorta grew clostridium septicum that was treated with antibiotics.201222410855
clostridium septicum aortitis with associated sigmoid colon adenocarcinoma.we report an unusual case of clostridium septicum aortitis with associated adenocarcinoma of the sigmoid colon. an 87-year-old man with multiple medical comorbidities presented with a 1-week history of severe abdominal pain in the left lower quadrant of his abdomen. abdominal computed tomography showed, in addition to a mass in the sigmoid colon, a gas density within the wall of the abdominal aorta with extensive periaortic fat stranding and some additional gas densities in the proximal left com ...201222304871
gas gangrene of the thigh in a morbidly obese patient with occult colon cancer.we report a case of atraumatic gas gangrene and myonecrosis of the leg secondary to infection with clostridium septicum in a severely obese patient with an occult cancer. she was treated successfully for both conditions. a review of the current literature describes this constellation of findings and the appropriate treatment.:201424345654
non-traumatic gas gangrene presenting as left buttock and thigh pain in a patient with metastatic non-small cell lung cancer.we report a case of clostridium septicum myonecrosis in a patient with metastatic non-small cell lung cancer receiving palliative chemotherapy. this is a rare but important differential diagnosis in patients with known malignancy presenting with acute pain. it is critical that the diagnosis is considered and confirmed promptly due to rapid deterioration and a potentially fatal outcome in the absence of aggressive treatment.201022791722
clostridium septicum infection associated with necrotizing pancreatitis, transmural gastric necrosis, and liquefaction of the spleen.spontaneous infection with clostridium septicum (c. septicum) is rare, but when isolated it is commonly associated with malignancy. we report a case of a 47-year-old man with infected pancreatic necrosis involving greater than 80% of the pancreas, transmural gastric necrosis, and liquefaction necrosis of the spleen. initial cultures revealed c. septicum infection. he was managed with prompt aggressive surgical debridément, resection, appropriate broad spectrum antibiotics, and early enteral nutr ...200826815495
mixed bacterial infections in relation to antibiotic activities. ii. the role of staphylococcal antibiotic in a clostridium septicum-staphylococcus albus infection. 195724544423
the effect of antibiotics on spores of clostridium septicum in vivo. 195424543102
spontaneous c. septicum gas gangrene: a literature review.as the infectious disease paradigm undergoes a subtle shift, unusual infections associated with malignancy and immunosuppression are being increasingly reported. spontaneous or non-traumatic clostridium septicum infection is one such unusual infection which has gained prominence. this article aims to understand the pathophysiology, clinical manifestations and current trends in diagnosing and treating this rare but deadly infection. to understand the multifactorial causation of this infection a r ...201728780428
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