acute abomasitis due to clostridium septicum infection in experimental sheep. 19836606419
fulminating clostridial septicemia in children treated for lymphoproliferative disorders.overwhelming clostridium septicum infection in 2 children, 1 and 4 yr old, with acute lymphoblastic leukemia and b-cell non-hodgkin malignant lymphoma, respectively, as well as fatal c. perfringens infection in a 3-yr-old child with histiocytosis-x are reported. a neutropenic patient with fever, abdominal symptoms and hypotension--but otherwise being well--must be suspected of having clostridial disease. the most alarming feature is shock and rapid course.19846610926
spontaneous clostridial myonecrosis.spontaneous, nontraumatic clostridial myonecrosis is a rare infection with an insidious onset and usually fatal outcome. spontaneous clostridial myonecrosis has a frequent association with colon carcinoma, leukemia, diabetes mellitus, and drug-induced immunosuppression. we present the case of a 73-year-old diabetic man who died of spontaneous clostridium septicum myonecrosis, who had presented with fulminant gangrene of the right thigh. clostridium septicum was cultured from the quadriceps muscl ...19921402768
serological characterization of clostridium septicum strains isolated from clinical materials of chickens and cows. 19836672417
neutropenic enterocolitis due to clostridium septicum infection.three cases of neutropenic enterocolitis are described. this unusual condition occurs almost exclusively in neutropenic patients and has a fulminating course which is almost invariably fatal without surgical intervention. the lesion is centered on the caecum and hitherto its pathogenesis has been unclear, partly because most studies have been performed on material obtained at necropsy. in these three patients, all of whom were treated surgically, clostridium septicum was identified by specific i ...19846699196
electron capture gas chromatography study of the acid and alcohol products of clostridium septicum and clostridium chauvoei.the metabolic products produced by several strains of clostridium septicum obtained from patients and animals, along with strains of clostridium chauvoei, were studied in chopped meat glucose medium by electron capture gas-liquid chromatography (ec-glc). the strains of c. septicum and c. chauvoei were shown to comprise five different metabolic groups. both the ec-glc study and the o and h antigenic study performed previously showed that strains of c. septicum comprise a heterogeneous group. one ...19761254716
successful therapy of clostridium septicum sepsis in a child with burkitt's lymphoma.the association between clostridium septicum sepsis in patients with malignant disease has been frequently documented. a presentation with fever, neutropenia, vomiting, and an acute abdomen is characteristic of this anaerobic infection which has been uniformly fatal in children with acute leukemia. we report the unusual course and the successful treatment of an adolescent with an abdominal burkitt's lymphoma with leukemic transformation and clostridium septicum sepsis and cellulitis.19816786126
clostridium septicum arthritis.this case of anaerobic septic arthritis caused by clostridium septicum is apparently the first reported. it emphasizes the need for obtaining anaerobic as well as aerobic cultures on all suspected cases of septic arthritis.19836828918
analysis of amines and other bacterial products by head-space gas chromatography.a gas chromatographic (gc) head-space technique is presented, which is suitable for the analysis of volatile products in bacterial broth cultures. this is exemplified by studies on clostridium septicum, klebsiella pneumoniae and proteus mirabilis. the media were acidified or made alkaline and after heating, samples of the gas phase above the media were directly injected into the gas chromatograph. a gas chromatograph equipped with dual columns and flame ionization detectors was used, employing p ...1978358746
clostridium septicum infection associated with colonic carcinoma and hematologic abnormality.six patients with clostridium septicum sepsis seen at duke university medical center over a two-year period also had other abnormalities, consisting of hematologic disorders in 3 and colon tumors in 3. three patients died of sepsis; 2 survived following disarticulation of the arm to control gas gangrene, while the sixth patient survived the sepsis but died of metastatic disease. when anaerobic cultures are positive for c. septicum, antibiotics should be given immediately. the high incidence of u ...19806934562
the effects of laboratory animal diets on the potency tests of bacterial vaccines.comparative studies of the responses elicited by mice fed on pcd and ffg diets to a number of bacterial vaccines have shown a significant reduction in the immune response to tetanus toxoid but not to clostridium septicum toxoid and increased resistance to challenge with e. coli and syngeneic tumour cells but not to pasteurella multocida. these differences cannot readily be explained in terms of differences between the identifiable constituents of the diets and illustrte the dangers of vaccine po ...19806995215
clostridium septicum infections and malignancy. 19827112192
isolation of clostridium septicum from diseased chickens in broiler farms. 19827161998
clostridium septicum in childhood leukaemia. 197773090
suppurative abomasitis associated with clostridium septicum infection.a 1-week-old calf and two 1-month-old lambs from different farms in eastern south dakota had severe abomasitis characterized by diffuse suppurative inflammation, edema, and emphysema. clostridium septicum in the abomasal wall of each was identified by immunofluorescence and isolation. the lesions and microbiologic findings established the disease as braxy, a condition infrequently reported in the united states and thought to affect sheep only.19817204251
a case of nontraumatic clostridial gas gangrene occurring in a patient with colon adenocarcinoma, liver cirrhosis, and diabetes autopsy case of clostridial gas gangrene occurring in a 54-year-old man with colon adenocarcinoma, liver cirrhosis, and diabetes mellitus is reported. the patient died 4 days after the onset of symptoms with episodes of vomiting and abdominal pain. gangrene of both hips and perineum, hemolysis, renal failure, and disseminated intravascular coagulation were the dominant clinical features. clostridium septicum was isolated from the subcutaneous tissue fluid. adenocarcinoma of the ascending colo ...19863739709
[clostridium septicum bacteremia in a diabetic patient (author's transl)].this report concerns the clinical and bacteriological study of a female diabetic who presented with a febrile illness of sudden onset and acute toxemia. physical examination at admission was unrewarding. a few hours after admission lesions characteristic of gas gangrene appeared in the right upper limb without prior trauma, and a clostridial infection was suspected. bacteriological studies of the exudate and of the patient's blood led to the isolation of clostridium septicum, thus confirming the ...19817218925
endogenous clostridium panophthalmitis.acute visual loss, pain, and redness in the left eye developed in a 61-year-old diabetic man. results of ophthalmologic examination showed 4+ conjunctival hyperemia and chemosis, no light perception, and restricted ocular motility. through a hazy cornea, a gas bubble was visualized filling about 50% of the anterior chamber. a vitreous tap disclosed myriad gram-positive rods with terminal and subterminal spores. cultures of the vitreous grew clostridium septicum, a gas-forming organism. explorato ...19873587922
[gas gangrene: an extreme surgico-medical rather than medico-surgical emergency].a diabetic woman developed spontaneous gas gangrene of upper limb extending into trunk and due to clostridium septicum. recovery was obtained after major surgery involving disarticulation of upper limb and excision of soft tissues of left hemithorax, and a difficult intensive care programme (hyperbaric oxygen therapy, assisted ventilation). the presence of this gas gangrene revealed a bipolar colon cancer treated in parallel. the conventional therapeutic hierarchy is discussed: surgery should be ...19873584286
gas gangrene: a postoperative complication.gas gangrene, also known as clostridial myonecrosis, is a severe and acute infection usually caused by clostridium septicum, which may contaminate a wound. on rare occasions it is a complication of elective bone surgery, although it is usually found in elderly persons after hip surgery. the onset is usually sudden and it may occur from 6 hr. to 3 days after tissue injury. diagnosis may be difficult because of the similarity of symptoms to those of anaerobic cellulitis. treatment consists of surg ...19807264230
carcinoma of the large intestine and nontraumatic, metastatic, clostridial myonecrosis.traumatic, clostridial myonecrosis is a rare and serious complication of wounds. nontraumatic, metastatic, clostridial myonecrosis may be caused by carcinoma of the large intestine. nontraumatic myonecrosis becomes evident with localized pain, generalized toxicity, local signs of inflammation, and crepitation. serum creatine kinase determinations may be of help in diagnosing patients suspected of having acute myonecrosis. immediate heroic surgical intervention, usually with demonstration of clos ...19863539558
susceptibility of clostridium septicum to 23 antimicrobial agents.the in vitro susceptibility of clostridium septicum was studied with a microtiter broth dilution method. several antimicrobial agents demonstrated consistently good activity against the organism.19817325648
neutropenic enterocolitis and clostridium septicum infection in patients with agranulocytosis.two patients with previously undiagnosed agranulocytosis had rapidly fatal clostridium septicum sepsis and neutropenic enterocolitis. this toxigenic organism has a known predilection for cecal lesions. the association reported herein suggests that c septicum may be the cause of this necrotizing enteropathy.19807387278
the haemorrhagic exudate and its possible relationship to neurogenic inflammation.the morphological effects of an aqueous solution of nistatin, of clostridium septicum and tityus serrulatus toxins, of bothrops jararaca and agkistrodon piscivorus venoms on the vessels of the tendinous portion of the diaphragm were investigated in guinea-pigs. it was demonstrated that all these substances, when injected intrapleurally induced not only an increase in the permeability of venules but also haemorrhages originating at this segment of the microcirculation. red cells were shown to esc ...19807400880
[ultrastructure of clostridium septicum].the study of cl. septicum by means of electron microscopy revealed that these organisms had peritrichously located flagella and the five-layer cell wall. the formation of small oval spores was observed by the end of the first day. the first sign of sporulation was the appearance of the prespore membrane followed by the formation of the prespore; the formation of the spore coat and the spore cortex began simultaneously at stage iv. the spore coat appeared first as short osmiphil scales. they were ...19807435021
arthritis caused by clostridium septicum. a case report and review of the literature. 19863512573
successful management of malignant edema caused by clostridium septicum in a horse.the clinical course and successful therapeutic management of a horse with malignant edema caused by clostridium septicum is described. this is believed to be the first report of a horse surviving malignant edema caused by c. septicum. a discussion of this disease syndrome, including etiology, pathogenesis, clinical signs, therapy, and diagnostic methods is presented.19873446445
myonecrosis due to clostridium septicum in a patient with unexplained neutropenia: successful treatment with granulocyte colony-stimulating factor.we report a case of sepsis due to clostridium septicum successfully treated with granulocyte colony-stimulating factor (gcsf). this case prompted our review of clostridial sepsis and considerations regarding the use of gcsf in cases of drug-induced neutropenia.19957541162
clostridial disease of the gut.clostridia are an important cause of morbidity and mortality in humans and animals. some of the most common clostridial infections are those of the gut. the primary infections in humans are clostridium perfringens food poisoning and clostridium difficile-mediated antibiotic-associated diarrhea and colitis. less common but important infections include non-food poisoning c. perfringens nosocomial diarrhea and c. perfringens type c necrotizing jejunitis (pig-bel). c. perfringens is also the dominan ...19957548565
sudden visual loss associated with clostridial bacteraemia.a patient with endogenously acquired clostridium septicum panophthalmitis is presented. the patient exhibited a striking sequence of signs and symptoms associated with this devastating ocular infection. intensive antibiotic therapy was ineffective and enucleation of the globe was required. the microscopic pathology of the enucleated globe showed extensive infarction and necrosis of ocular structures in association with the panophthalmitis. in addition thrombosis of the central retinal artery and ...19883395597
clostridium septicum bacteremia associated with aortic graft infection.after emergency repair of a ruptured abdominal aortic aneurysm associated with an aortocaval fistula, clostridium septicum sepsis prompted evaluation for colon cancer. adenocarcinoma of the right colon ultimately required hemicolectomy, after which the patient had development of recurrent c. septicum bacteremia. computed tomography scanning demonstrated a large fluid collection surrounding the aortic graft, and percutaneous drainage documented recurrent c. septicum. initial axillobifemoral bypas ...19957563411
malignancy, mortality, and medicosurgical management of clostridium septicum infection.necrotizing clostridium septicum infections (csi) have a strong association with malignancy or immunosuppression. to clarify this relationship and determine how it impacted mortality, the experience with csi at a single institution was reviewed.19957570310
[gas gangrene as presentation of colonic carcinoma in familial adenomatous polyposis].one case of gas gangrene by clostridium septicum associated to colon cancer is herein presented. spontaneous gas gangrene is often associated with neoplasms among which hematologic and colon neoplasms are the most frequent. the present case has also peculiarity that the colon cancer had developed from a familiar adenomatous polyposis syndrome.19957584783
brain abscesses caused by clostridium septicum as a complication of hemolytic-uremic syndrome. 19957715999
purulent pericarditis due to clostridium septicum associated with carcinoma of the colon. 19957727661
peritonitis due to clostridium septicum in a capd patient. 19957734578
clostridium septicum primary myonecrosis related to cecal neoplasia. 19957775706
[infection by clostridium septicum as a presenting form of colonic neoplasia]. 19957779902
clinical courses of seven survivors of clostridium septicum infection and their immunologic responses to alpha toxin.clostridium septicum bacteremia typically portends a fulminant disease associated with high mortality. we describe the clinical courses of seven survivors of c. septicum infection and their antibody responses to the alpha toxin produced by c. septicum. three patients had clinical syndromes ranging from uncomplicated bacteremia to early typhlitis, and three patients had syndromes ranging from abscess to myonecrosis and septic shock. in addition, an aids patient who developed septic shock and who ...19947803645
gene structure of the 'large' sialidase isoenzyme from clostridium perfringens a99 and its relationship with other clostridial nanh proteins.clostridium perfringens possesses two sialidase isoenzymes of different molecular weight. almost 90% of the gene encoding the 'large' form was found on a 3.1 kb chromosomal fragment (sau3ai) of strain a99 by hybridization with probes developed from the n-terminal protein sequence and from commonly conserved sialidase motifs ('asp-boxes'), whereas the remaining 3'-terminal part was detected on a 2.1 kb fragment (hind iii) of chromosomal dna. after combination of both fragments, the resulting e. c ...19947804004
the primary structure of clostridium septicum alpha-toxin exhibits similarity with that of aeromonas hydrophila aerolysin.the gene for clostridium septicum alpha-toxin was cloned and expressed in escherichia coli from c. septicum bx96. the toxin was determined to be 443 amino acids in length, with a 31-residue signal peptide that was removed from the toxin during secretion. no extended hydrophobic regions were observed in the mature toxin sequence. expression of alpha-toxin in e. coli bl21 resulted in the production of atpro, which was identical to native toxin from c. septicum with respect to activity and activati ...19957806374
invasive clostridium septicum infection in association with colorectal carcinoma. 19947922895
clostridium septicum septicaemia in a patient with leukaemia.clostridium septicum infection has been shown to have a strikingly high association with either bowel or blood malignancies. the infection may be fatal if unrecognised. we report a case of c. septicum bacteremia in a man diagnosed with acute myeloid leukaemia.19947939827
clostridium septicum gas gangrene of the gluteus maximus and an ascending colon malignant tumor. a case report.clostridial myonecrosis is a complication associated with contaminated traumatized wounds. presented is the case of an elderly female with pain in her right hip, radiographic evidence of gas in the soft tissues, and no history of trauma. evaluation of this patient revealed clostridial myonecrosis. culture results identified the organism as clostridium septicum. due to the association between clostridium septicum and occult malignancies, colonoscopic evaluation was performed. a colonic lesion was ...19947955680
diffuse spreading clostridium septicum infection, malignant disease and immune suppression.nineteen patients have been treated with gas gangrene infection proved on cultures to be caused by clostridium septicum. infection occurred after trauma in three patients and occurred spontaneously in 16, including six patients with peritonitis. none of the instances occurred as a postoperative infection. ten of the patients had an associated malignant disease including carcinoma of the colon and rectum in six, hematologic malignant conditions in three and carcinoma of the gallbladder in one. of ...19883344448
clostridium septicum syndrome. 19947978581
spontaneous clostridium septicum myonecrosis in congenital neutropaenia.spontaneous clostridium septicum myonecrosis is an uncommon disorder that has been described in association with malignancy, immunosuppression and neutropaenia. typical clostridial myonecrosis develops without a visible portal of entry and mortality is high. the pathogenesis is not completely understood but the clostridia may gain access to the circulation via areas of ileo-caecal ulceration secondary to enterocolitis, antibiotics or neoplasms. a 5 year old boy with congenital neutropaenia prese ...19948048901
acute ileotyphlitis as presenting manifestation of acute myelogenous leukemia.a case of acute myelogenous leukemia is reported in a child who presented with acute ileotyphlitis and died of an over-whelming clostridium septicum sepsis before the chemotherapy was administered. the pathogenesis of acute ileotyphlitis, especially the role of granulocytopenia is discussed.19883162345
differentiation of hl-60 cells is promoted by h-toxin of clostridium septicum.h-toxin of clostridium septicum potentiated dimethyl sulfoxide (dmso)-induced differentiation of human promyelocytic leukemia hl-60 cells which were monitored by nuclear morphology and production of oxidative radicals. but, h-toxin did not induce differentiation of hl-60 cells in the absence of dmso. these phenomena were not observed by staphylococcal leukocidin, a cytotoxin affecting to hl-60 cells. in hl-60 cells, adp-ribosylation of 118, 93, 75 and 58 kda membrane proteins was observed, but t ...19948082787
clostridium septicum gangrene complicating a closed femoral of the basic principles of orthopedic surgery is that gas gangrene does not develop in closed fractures. that there are exceptions to this rule is demonstrated by the following report of an extremely rare case. clostridium septicum myonecrosis developed after surgical treatment of a closed femoral fracture in a fit 45-year-old man, treated by antibiotics. the patient survived after having a right hip disarticulation and administration of high doses of intravenous penicillin. prophylactically ...19938116380
clostridium septicum and neutropenic enterocolitis. 19872890893
clostridium septicum infection and associated malignancy. report of 2 cases and review of the literature.we report 2 patients with myonecrosis due to clostridium septicum and associated colon carcinoma and have reviewed the english language literature for all reported cases of atraumatic c. septicum infection. a total of 162 cases of c. septicum infection have been reported. eighty-one percent of these patients had an associated malignancy. thirty-four percent of all patients had associated colon carcinoma, while 40% had a hematologic malignancy. thirty-seven percent of reported patients had an occ ...19892642585
aortitis due to metastatic gas gangrene.clostridium septicum bacteremia and its association with hematologic malignancy and colorectal cancer have been well recognized. panwalker, in a recent review, discussed clostridial sepsis and other unusual infections associated with colorectal tumors, including streptococcal bovis and bacteroides. he reports the coexistence of colorectal cancer and metastatic clostridium septicum infections at multiple sites. we describe a case in which a patient with an occult cecal carcinoma develops clostrid ...19892618068
gas gangrene from subcutaneous insulin administration.a case of gas gangrene that caused intractable shoulder pain refractory to narcotics in an immunocompromised host is presented. gas gangrene has been associated with severe trauma involving penetrating wounds, compound fractures, extensive soft-tissue injury, intramuscular injection of epinephrine, and interruption of arterial blood supply. this case describes an elderly insulin-dependent diabetic woman who developed gas gangrene in her arm and leg at the site of her subcutaneous insulin injecti ...19938240568
clostridium septicum gas gangrene following intramuscular infection from an influenza vaccine booster.we have reported a case of c septicum gas gangrene occurring in the forearm of a patient who had an influvac influenza booster 48 hours before admission. despite prompt antibiotic treatment and surgical debridement, the patient became hypotensive and could not be resuscitated.19902102204
fatal clostridium septicum myonecrosis.a 20 year old leukaemic patient with neutropaenia secondary to chemotherapy, who developed overwhelming sepsis, myonecrosis, vascular occlusion and necrotizing enterocolitis due to clostridium septicum infection is described. plain abdominal radiographs and a computed tomography scan of the abdomen and pelvis showed gas in the retroperitoneal soft tissues. clostridium septicum septicaemia has a recognized association with malignancy and neutropaenia and has a high mortality if not diagnosed and ...19938257347
actions of three clostridial iga proteases on distinct forms of immunoglobulin a molecules.three bacterial species of clostridium (septicum, tertium and sporogenes) were identified to produce extracellular proteases cleaving iga to fab and fc fragments, as demonstrated by sds-page and immunoelectrophoretic procedures. these enzymes acted on monometric iga1 paraproteins and normal serum iga1 but had no activity on iga2 paraproteins and intact secretory iga1 from human colostrum. their action on polyclonal serum iga1 suggested the absence of neutralizing anti-clostridial iga protease ac ...19912071167
histopathologic effects of culture filtrates of clostridium septicum in rabbit intestinal loops. 19938324121
the sialidase gene from clostridium septicum: cloning, sequencing, expression in escherichia coli and identification of conserved sequences in sialidases and other oligonucleotide mixture corresponding to the codons for conserved and repeated amino acid sequences of bacterial sialidases (roggentin et al. 1989) was used to clone a 4.3 kb psti restriction fragment of clostridium septicum dna in escherichia coli. the complete nucleotide sequence of the sialidase gene was determined from this fragment. the derived amino acid sequence corresponds to a protein of 110,000 da. the ribosomal binding site and promoter-like consensus sequences were identified upst ...19912034213
isolation and properties of the natural and the recombinant sialidase from clostridium septicum nc 0054714.the natural sialidase of clostridium septicum was purified and characterized in parallel with the recombinant enzyme expressed by escherichia coli. the two enzymes exhibit almost identical properties. the maximum hydrolytic activity was measured at 37 degrees c in 60 mm sodium acetate buffer, ph 5.3. glycoproteins like fetuin and saponified bovine submandibular gland mucin, most of them having alpha(2-6) linked sialic acids, are preferred substrates, while sialic acids from gangliosides, sialyll ...19938358227
abdominal pain associated with an umbilical abscess in a llama.a 3-month-old llama with a presenting complaint of lethargy, anorexia, and a painful, distended abdomen was evaluated. the llama had intermittently strained to defecate during the 3 days prior to admission. physical examination results, hematologic data and lateral abdominal radiographs were used to diagnose a large umbilical abscess, which was causing a partial obstruction of the gastrointestinal tract. under general anesthesia, 3 liters of purulent exudate were drained from the abscess. the ab ...19938417858
diffuse pneumocephalus due to clostridium septicum cerebritis in haemolytic uraemic syndrome: ct demonstration.the computed tomography finding of diffuse pneumocephalus due to infection by gas-forming organisms is very unusual. we report such a case due to secondary infection by clostridium septicum in a child with diarrhoea-associated haemolytic uraemic syndrome.19938459926
clostridium septicum septicemia in a neonatal foal with hemorrhagic enteritis.clostridium septicum was isolated by anaerobic culture of blood collected from a 3-day-old foal with hemorrhagic enteritis and signs suggestive of septicemia. the foal responded well to treatment with intravenous fluids, antibiotics, plasma, and oral gastrointestinal protectants. one month after apparent complete recovery from the septicemia and hemorrhagic enteritis, the foal was euthanized during an acute episode of colic that was caused by severe, strangulating intestinal adhesions, thought t ...19938467700
recognition, management, and prevention of clostridium septicum abscess in immunosuppressed patients.spontaneous gas gangrene due to clostridium septicum is a rapidly progressing disease that usually ends in fatal toxemia. we report three cases of asymptomatic c septicum abscesses to document the clinical course of this entity and to establish guidelines for its prevention and treatment. in contrast to previously reported data, c septicum infections can produce abscesses in solid organs, the retroperitoneum, and the extremities. these lesions often occur in patients with cancer, producing liver ...19912021349
clostridial endocarditis: report of a case caused by clostridium septicum and review of the literature.we describe a case of fatal infective endocarditis due to clostridium septicum in a patient with underlying colonic carcinoma. this is believed to be the first reported case of c. septicum endocarditis. the literature on the subject is reviewed.19938505566
gas composition in clostridium septicum gas gangrene.clostridial gas gangrene (myonecrosis) is a rare but catastrophic condition that usually occurs in patients with underlying diseases. this paper reports a fatal case of spontaneous clostridial gas gangrene in a 60-year-old female diabetic patient. the composition of gas samples from the patient's damaged muscle was analyzed. the results showed 5.9% hydrogen, 3.4% carbon dioxide, 74.5% nitrogen and 16.1% oxygen. this gas composition supports the belief that such gas production occurs via glucose ...19958541740
[gas gangrene as a manifestation of endogenous clostridium septicum infection].endogenous, nontraumatic clostridial myonecrosis has a frequent association with colon carcinoma, leukemia, diabetes mellitus, and drug-induced immunosuppression. we present two cases of clostridium septicum myonecrosis. an 18-year-old girl developed severe abdominal pain on day 7 after hospitalization for cytostatic treatment of acute lymphoblastic leukemia. blood cultures yielded clostridium septicum and histopathological exam of muscle tissue showed extended myonecrosis. eventually the patien ...19958582739
primary clostridium septicum aortitis: a rare cause of necrotizing suprarenal aortic infection. a case report and review of the literature.a 74-year old woman sought medical attention for general symptoms of nausea, vomiting, and back pain. a computed tomographic scan showed gas in the wall of the descending thoracic and suprarenal aortas. emergency thoracoabdominal exploration revealed a necrotizing infection of the thoracic aorta extending to the origin of the celiac axis. after surgery clostridium septicum was identified in tissue culture. surgical management consisted of in-situ graft replacement of the thoracoabdominal aorta. ...19968627911
cloning and expression of sialidase l, a neuacalpha2-->3gal-specific sialidase from the leech, macrobdella decora.sialidase l is a neuacalpha2-->3gal linkage-specific sialidase that releases 2,7-anhydro-neuac instead of neuac from sialoglycoconjugates (chou, m.-y., li, s.-c., kiso, m., hasegawa, a., and li, y.-t.(1994) j. biol. chem. 269, 18821-18826). a 2. 5-kilobase cdna of sialidase l was cloned by a combination of methods based on polymerase chain reactions. the composite cdna sequence reveals an open reading frame coding for 762 amino acids, including a putative 28-residue signal peptide at the n termi ...19968702601
periodic recurrence of gangrenous dermatitis associated with clostridium septicum in a broiler chicken operation. 19968744754
double clostridial mycotic aneurysms of the aorta.mycotic aortic aneurysm continues to present challenging and difficult management issues with a significant morbidity and mortality. the offending organism in the etiology of this aneurysm can be variable and unusual. the first report of two mycotic aortic aneurysms caused by clostridium septicum in the same patient is described here. presentation and management as well as conditions commonly associated with clostridium septicum infection and a review of all clostridial mycotic aortic aneurysms ...19958745194
cloning and characterization of nanb, a second streptococcus pneumoniae neuraminidase gene, and purification of the nanb enzyme from recombinant escherichia coli.streptococcus pneumoniae is believed to produce more than one form of neuraminidase, but there has been uncertainty as to whether this is due to posttranslational modification of a single gene product or the existence of more than one neuraminidase-encoding gene. only one stable pneumococcal neuraminidase gene (designated nana) has been described. in the present study, we isolated and characterized a second neuraminidase gene (designated nanb), which is located close to nana on the pneumococcal ...19968759848
clostridium septicum septicemia with identical metastatic myonecroses in a granulocytopenic patient. infectious disease emergency.clostridium septicum is a gram-positive, sporulating spindle-shaped rod. gas gangrene secondary to trauma is not uncommon. however, nontraumatic clostridial infection causing myonecrosis is quite unusual. this is a unique case report of clostridium septicum bacteremia with two simultaneously evolving metastatic foci of myonecrosis of the left arm and right thigh that developed in a patient with lymphoma when he became granulocytopenic during his hospital course.19854025378
phylogenetic positions of clostridium chauvoei and clostridium septicum based on 16s rrna gene sequences.the sequences of the 16s rrna genes (rrs genes) of clostridium chauvoei, the causative agent of blackleg in cattle, and the phenotypically related organism clostridium septicum were determined. after amplification of 1,507-bp pcr fragments from the corresponding rrs genes, the sequences were determined in a single round of sequencing by using conserved region primers. a sequence similarity analysis of the sequences revealed the close phylogenetic relationship of c. chauvoei and c. septicum in cl ...19968863454
mycotic aneurysm of the thoracic aorta caused by clostridium septicum.we describe a case-of a 78-year-old man who presented with a mycotic aneurysm of the thoracic aorta caused by clostridium septicum and underwent successful resection. there are only 3 cases of mycotic aneurysms caused by clostridium septicum reported in the literature. clostridium septicum infections have been shown to have a high association with gastrointestinal and hematologic malignancies. all patients with clostridium septicum infections, therefore, require a search for gastrointestinal les ...19968957398
bovine clostridial infections in zambia (1985-1994).retrospective surveillance study of clostridial infections of cattle in zambia, for the period 1985 to 1994, showed that out of the 318 cases observed, 62.8% and 24.2% were from western and southern provinces, respectively. of the 6 clostridia species identified, clostridium septicum (38.1%) followed by c. chauvoei (36.2%) and c. perfringens (13.2%) were dominant. although the highest incidence for clostridial infections was in 1989 (75 cases) and 1990 (77 cases), the number of c. perfringens ca ...19968997878
clostridium septicum infections and malignancy. 19695819436
clostridium septicum and malignancy. 19695819442
cns infection and bacteremia due to clostridium septicum.central nervous system infection with clostridium septicum is rare. we report two fulminant cases of such infection with accompanying bacteremia. the presence of extensive brain necrosis was striking in our two cases. the association of c septicum bacteremia with hematologic disease, and with solid tumors, was present in our cases. we conclude that c septicum should be considered as a potential cause of life-threatening bacteremia and meningitis in the compromised host.19846466165
[gas gangrene due to clostridium septicum in a patient with an occult colonic neoplasm. a case report and review of the literature].a case of gaseous gangrene by clostridium septicum associated with colorectal cancer is presented. the patient evolved rapidly towards septic shock and death. autopsy showed occult neoplasm and pelvic and retroperitoneal myonecrosis. an exceptional finding was that of myocarditis in which thick gram-positive bacilli were identified. a review of the literature was carried out regarding the pathogenesis and clinical manifestations of this disease. the association of colonic neoplasm and clostridiu ...19979072204
clostridium septicum sepsis and neutropenic enterocolitis in a patient treated with intensive chemotherapy for acute myeloid leukemia.we report a case of neutropenic enterocolitis complicated by clostridium septicum sepsis following intensive chemotherapy to induce remission of acute myeloid leukemia. with the trend towards more intensive chemotherapy, particularly using regimens that induce gastrointestinal toxicity, it is important to recognize the circumstances under which sepsis due to c. septicum is likely to occur, so that appropriate treatment can be instituted promptly.19979111429
nontraumatic clostridium septicum gangrenous myonecrosis.nontraumatic clostridium septicum infections may present as either septicemia or as metastatic myonecrosis. most of these infections occur in debilitated patients with diabetes who are receiving cancer chemotherapy. the majority have a hematologic abnormality or a carcinoma of the colon. usually there is an ulcerative lesion of the gastrointestinal tract that serves as the portal of entry. while most of these patients die from overwhelming sepsis, our patient was debrided early and treated promp ...19836628141
aortic dissection due to clostridium septicum infection. 19979166278
central nervous system infection due to clostridium septicum: a case report and review of the literature.a patient with end stage breast cancer was admitted to hospital due to fever, chills, multiply eroded discharging wounds, and sudden onset of left hemiparesis. clostridium septicum bacteremia and brain abscess were diagnosed. the patient was treated successfully with intravenous penicillin and clindamycin and stereotactic aspiration of the abscess. eleven cases of c. septicum central nervous system infection are reviewed. they showed an extremely fulminant course and high fatality. nevertheless, ...19979181386
surgical aspects of clostridium septicum septicemia.clostridium septicum is a virulent cause of gas gangrene and sepsis. although thought to be rare, a survey of our affiliated hospitals for a recent five-year period disclosed eight cases. seven of the eight had an occult malignant neoplasm. the eighth patient was thought to be preleukemic. all seven malignant neoplasms involved the gastrointestinal tract. four patients were admitted with gangrene of an extremity, three with abdominal pain, and one with both. in four patients, c septicum septicem ...19846712467
spontaneous gas gangrene: an unusual complication of colonic carcinoma.clostridium septicum myonecrosis is an acutely painful and rapidly fatal infection occurring in the absence of trauma. urgent surgery is essential both to maximize survival and to provide effective pain control. the majority of patients who develop this infection have an underlying malignancy and clinicians involved in the care of cancer patients should be aware of this condition. we present a case report and summarize the literature to date.19979269553
clostridium septicum infection in children with cyclic neutropenia.atraumatic clostridium septicum infection is rare in infancy and childhood and is associated with a high mortality rate. although in adults it has been reported to occur mainly in patients with gastrointestinal malignancy, pediatric cases were always associated with neutropenia. about 70% of the cases were described in children with neutropenia caused by chemotherapy and 30% were found in children with cyclic neutropenia. no case was described in children with other forms of congenital severe ne ...19979290625
occult clostridial myonecrosis.nontraumatic gas gangrene is extremely rare. it usually occurs following ulceration or perforation of an abdominal or pelvic viscus in persons having impaired host immune defenses. a fatal case of nontraumatic clostridium septicum septicemia and myonecrosis in an elderly diabetic man with a perforated colon carcinoma is presented. the case illustrates the occult manner in which such cases typically present and the fulminant course of this disease. the need for rapid diagnosis and the current rec ...19817235340
effect of temperature and glucose concentration on dnase production by clostridium septicum. 19979310663
antibody responses to clostridial infection in humans.serum antibody responses to the major toxins produced by clostridium difficile, clostridium perfringens, clostridium septicum, clostridium tetani, and clostridium botulinum have been documented following infection. effective toxoid vaccines for tetanus and enteritis necroticans due to c. perfringens type c demonstrate the potential of antitoxin responses. although individual serum and mucosal antibody responses to c. difficile enterotoxin (toxin a) vary, one-third of patients with c. difficile d ...19979310668
a coincidence of disastrous accidents: crohn's disease, agranulocytosis, and clostridium septicum infection. 19979314329
nontraumatic clostridial myonecrosis: an infectious disease emergency.a 64-year-old man presented with a history of four days of lower abdominal pain and 12 hours of cutaneous discoloration, bullae formation, and swelling of the soft tissues of abdominal wall and right thigh. myonecrosis of abdominal wall and an adenocarcinoma of the cecum were found at operation. cultures of blood and fluid from the bullae yielded clostridium septicum. nontraumatic clostridial myonecrosis is a fulminant, usually fatal disease that is most often the result of bacteremia from an oc ...19817235341
clostridium septicum infection in cattle in the united states. 19817309612
another cause of necrotizing fasciitis?necrotizing fasciitis is a rare condition, but has a devastating clinical course if it is not diagnosed early and treated aggressively. there are usually a number of organisms implicated in its pathogenesis, but in this case report a patient is presented in whom the only organism isolated from both tissue and blood cultures was clostridium septicum. this organism almost always causes a myonecrosis, but in this case only the superficial and deep fascial layers were affected, sparing the underlyin ...19979354354
identification of clostridium chauvoei in cultures and clinical material from blackleg using identification system for clostridium chauvoei, using pcr amplification of the 16s rrna gene (rrs) with specific oligonucleotide primers and subsequent restriction digestion of the amplification product is described. the specific oligonucleotide primers were designed based on the rrs gene sequences of c. chauvoei by comparing it to the dna sequences of the rrs genes of its most closely related species clostridium septicum and clostridium carnis. a subsequent restriction digestion of the 960 b ...19979355263
clostridium septicum endocarditis complicated by aortic-ring abscess and aortitis. 19989502477
aerolysin--a paradigm for membrane insertion of beta-sheet protein toxins?the determination of the crystal structure of the bacterial protein proaerolysin provided the first view of a pore-forming toxin constructed mainly from beta-sheet. the structure that was obtained and subsequent crystallographic and biochemical studies have together allowed us to explain how the toxin is transformed from a water-soluble dimer to a heptameric transmembrane pore. recent discoveries of structural similarities between aerolysin and other toxins suggest that the structure/function st ...19989615432
clostridium septicum infection and hemolytic uremic syndrome.five cases of clostridium septicum infection secondary to escherichia coli o157-induced hemolytic uremic syndrome have been reported. we report on three cases (one of which is included in the above five) of dual cl. septicum and e. coil infection; all three patients were exposed to farm animals. a common zoonotic source for cl. septicum and e. coli o157 infections should be considered. patients with hemolytic uremic syndrome should be treated aggressively and monitored closely for cl. septicum s ...19989621207
clostridium septicum myonecrosis presenting as a parapharyngeal abscess in a patient with aplastic anemia.the first reported case of clostridium septicum myonecrosis in an adult with aplastic anemia is described. the patient presented with sepsis, a parapharyngeal abscess that necessitated emergent intubation, and severe intravascular hemolysis attributed to clostridial alpha-toxin production. despite prompt recognition and treatment, the patient died of his infection. c. septicum myonecrosis should be considered in any immunocompromised patient with sepsis, especially when accompanied by evidence o ...19989795792
clostridium septicum osteomyelitis: case report and review. 19989802642
Displaying items 101 - 200 of 506