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quantitative chemical analyses and antigenic properties of peptidoglycans from clostridium botulinum and other clostridia.the cell wall peptodoglycans were isolated from clostridium botulinum and some other species of the genus clostridium by hot formamide extraction and their quantitative chemical composition and antigenic properties were determined. the petidoglycan of c. botulinum type e was found to be a diaminopimelic acid (dap)-containing type composed of glucosamine, muramic acid, glutamic acid, alanine and dap in the molar ratio of 0.76:0.78:1.00:1.88:0.81. all other types of c. botulinum and clostridium sp ...197662070
purification of clostridium toxoids.a two-step fractionation procedure was applied for purification and concentration of the individual clostridium toxoids. the toxoids were precipitated with hydrochloric acid in the presence of sodium sextametaphosphate, then antigenic fractions were separated from inactive contaminants by sephadex g-75 filtration. specific activity of the preparations thus obtained, as determined by mancini radial immunodiffusion, was 150--565 binding units per mg of protein nitrogen for clostridium perfringens ...197770974
clostridium septicum in childhood leukaemia. 197773090
growth of clostridium tertium and clostridium septicum in chemically defined media.defined media for the growth of clostridium tertium and clostridium septicum are described. the requirements for growth of these two species are compared with each other and with those of clostridium perfringens.1976180884
multiple hepatic tumors and peliosis hepatis in fanconi's anemia treated with androgens.we report the case of a 13-year-old boy who was known to have fanconi's anemia for five years. for treatment of this condition he was given androgens and corticosteroids. two months before his death, severe varicella developed complicated by pneumonia, jaundice, and prolonged fever; all of which resolved during a five-week hospitalization. three weeks later he died of clostridium septicum sepsis caused by necrotizing enterocolitis. at autopsy he was found to have multiple hepatocellular neoplasm ...1977199056
clostridium septicum infection in childhood leukemia: report of a case and review of the literature.overwhelming clostridium septicum infection is a rare occurrence in children. it is seen almost exclusively as a complication of acute leukemia. a high index of suspicion in the leukemic child with an acute abdomen is the key to early diagnosis and improved survival. a case in a 13-year-old girl with acute myelogenous leukemia is reported and six pediatric cases in the literature were reviewed.1977268232
[clostridium septicum infection in acute leukemia]. 1979286885
necrotising enterocolitis associated with invasion by clostridium septicum complicating cyclic neutropaenia.a fatal case of necrotising enterocolitis complicating cyclic neutropaenia in a 17-year-old boy is reported. the episode of enterocolitis was characterised by fulminant, generalised peritonitis associated with necrosis and gas formation in the wall of the ileum and caecum. clostridium septicum was grown from premortem blood cultures and gram positive bacilli typical of this organism were present in histological sections of the bowel wall. necrotising enterocolitis in this and previously reported ...1979292384
analysis of amines and other bacterial products by head-space gas chromatography.a gas chromatographic (gc) head-space technique is presented, which is suitable for the analysis of volatile products in bacterial broth cultures. this is exemplified by studies on clostridium septicum, klebsiella pneumoniae and proteus mirabilis. the media were acidified or made alkaline and after heating, samples of the gas phase above the media were directly injected into the gas chromatograph. a gas chromatograph equipped with dual columns and flame ionization detectors was used, employing p ...1978358746
clostridium septicum bacteremia. its clinical significance.the medical records of 59 patients with clostridium septicum bacteremia were reviewed; 42 (71 per cent) of these patients had malignancies. one half had hematologic malignancies, and one half had solid tumors. of the 21 patients with solid tumors, 14 (67 per cent) had cancer of the colon. among these patients, the cecum was the most frequent site of malignancy. the cecum and distal ileum were the most probable portals of entry for c. septicum bacteremia among the 28 patients examined at autopsy. ...1979420252
postoperative clostridium septicum dermatitis simulating toxic epidermal necrolysis.widespread detachment of the epidermis as a result of clostridium septicum infection after a laparotomy for intestinal obstruction is described. a clinicopathological picture, hitherto undescribed, is outlined.1979472950
immunogenicity of clostridium septicum in guinea pigs.five strains of clostridium septicum were used to prepare bacterins, bacterin-toxoids, toxoid, and combinations of bacterins or bacterin-toxoids. these preparations were tested for immunogenicity in guinea pigs vaccinated subcutaneously with 1.0 ml of product. usually, a second vaccination was given 21 to 24 days later. the immunity of groups of vaccinated guinea pigs was challenged with as many as 22 strains of c septicum. when challenge exposed with homologous strains at 21 to 24 days after on ...1979525895
differentiation in the cytotoxicity between hemorrhagic and necrotizing principles produced by clostridium septicum. 1979541869
deoxyribonucleases and hyaluronidases of clostridium septicum and clostridium chauvoei. iii. relationship between the two organisms. 1976940440
potency testing of clostridium septicum bacterins in sheep and laboratory animals.the immunogenic potency of bacterins containing clostridium septicum was evaluated in mice, hamsters, guinea pigs, rabbits and sheep to establish potency requirements for these bacterins. two subcutaneous injections of cl. septicum bacterins were shown to provide resistance against intramuscular spore challenge. protection in mice, hamsters and guinea pigs was generally at low levels, in the range of 1 to 5 ld50. efficacy estimates, at these levels of challenge, indicated that a degree of relati ...19761001825
preparation and evaluation to clostridium septicum toxoid.clostridium septicum was grown under controlled conditions to produce high levels of alpha toxin. the toxin was toxoided and concentrated by ultrafiltration. the toxoided alpha toxin retained immunizing properties. the concentrated toxoid, when formulated on total combining power, in monovalent or multivalent clostridial products, provided protection to rabbits against direct challenge with cl. septicum spores. the toxoided alpha toxin produced antitoxin levels which exceeded current minima.19761001826
chronic clostridium septicum infection of a tibial fracture: a case report.an open transverse fracture of the mid-shaft of the tibia of a professional footballer became infected by clostridium septicum and, after early compression plating, required surgical intervention on three further occasions and extensive antibiotic treatment before healing occurred. clostridial infection is a recognized complication of open fractures contaminated with soil, and the necrotizing toxins produced by the c. septicum were probably responsible for the persistence of this infection. infe ...19761002285
clostridium septicum infection and antibiotic treatment in broiler chickens. 19751114625
letter: clostridium septicum infection in chickens. 19751114642
letter: an outbreak of gangrenous cellulitis caused by clostridium septicum in a broiler flock. 19751164275
[bacteriocins of clostridium septicum (author's transl)].17 strains of clostridium septicum were examined for bacteriocin production. two bacteriocin-producing strains were detected by the stab culture method and the spot test using the supernatant fluids of the cultures. the bacteriocin of cl. septicum ovinus was active against all other strains of cl. septicum without inhibiting the donro strain (table 2). this bacteriocin and one indicator strain (wex) were chosen for further study. the bacteriocin, which was spontaneously produced during the logar ...19751221680
studies on mode of action of a bacteriocin from clostridium septicum.a bacteriocin was found in the supernatant fluid of clostridium septicum strain ovinus. sensitivity to the bacteriocin was confined to other strains of c. septicum and to strains of c. chauvoei; the other gram-positive and gram-negative bacteria tested for sensitivity were unaffected by the bacteriocin. the bacteriocin killed sensitive cells rapidly but cell lysis did not appear to be involved. the bacteriocin inhibited protein and rna synthesis immediately after its addition to sensitive cells; ...19761253001
electron capture gas chromatography study of the acid and alcohol products of clostridium septicum and clostridium chauvoei.the metabolic products produced by several strains of clostridium septicum obtained from patients and animals, along with strains of clostridium chauvoei, were studied in chopped meat glucose medium by electron capture gas-liquid chromatography (ec-glc). the strains of c. septicum and c. chauvoei were shown to comprise five different metabolic groups. both the ec-glc study and the o and h antigenic study performed previously showed that strains of c. septicum comprise a heterogeneous group. one ...19761254716
recombinant human granulocyte colony-stimulating factor promotes wound healing in a patient with congenital neutropenia.we report a patient with congenital neutropenia or kostmann's syndrome who suffered many complications after presenting with clostridium septicum enterocolitis, including absence of wound healing. because of several reports of the use of granulocyte colony-stimulating factor (g-csf) in patients with various complications of neutropenia, we treated this patient with recombinant human (rh) g-csf. we found that once rhg-csf restored neutrophil counts to normal, progressive wound healing followed. t ...19921380074
spontaneous clostridial myonecrosis.spontaneous, nontraumatic clostridial myonecrosis is a rare infection with an insidious onset and usually fatal outcome. spontaneous clostridial myonecrosis has a frequent association with colon carcinoma, leukemia, diabetes mellitus, and drug-induced immunosuppression. we present the case of a 73-year-old diabetic man who died of spontaneous clostridium septicum myonecrosis, who had presented with fulminant gangrene of the right thigh. clostridium septicum was cultured from the quadriceps muscl ...19921402768
occult gastrointestinal malignancies producing metastatic clostridium septicum infections in diabetic patients.clostridial soft-tissue infections usually occur from traumatic injury but may be related to unrecognized gastrointestinal malignancy. overwhelming sepsis with clostridium septicum developed in five diabetic patients within 24 hours of onset of disease, and their course is reviewed.19921411949
clostridium septicum meningoencephalitis: an unusual presentation of occult rectal carcinoma. 19921414846
cerebral abscess due to clostridium septicum. 19921433051
demonstration of clostridium septicum infection in a goose flock.clostridium septicum infection causing 5.0 to 5.2% mortality is reported for the first time in the literature from six-week-old growing geese in three flocks comprising 5,200, 5,500 and 5,900 geese, respectively. the affected birds exhibited weakness, uncoordinated movement, ataxia and, frequently, oblique position of the head and neck (torticollis) as well as signs indicative of dysequilibrium. the affected birds died within 18-24 h. gross pathological examination revealed anaemia, hepatitis wi ...19921476092
clostridium septicum infections in children. 19921528648
purification and characterization of the lethal toxin (alpha-toxin) of clostridium septicum.clostridium septicum lethal (alpha-toxin) was purified and found to be a basic protein (pi 8.4) of approximately 48 kda that is both lethal and hemolytic. the alpha-toxin had a hemolytic activity of approximately 2 x 10(7) hemolytic units per mg and a 50% lethal dose of approximately 10 micrograms/kg of body weight for mice. the alpha-toxin formed concentration-dependent, sodium dodecyl sulfate-resistant aggregates of approximately 230 kda. mice immunized with alpha-toxin showed a significant in ...19921541552
purulent thromboembolic meningoencephalomyelitis in a calf with isolation of clostridium septicum from the brain. 19921558882
non-traumatic clostridium septicum arthritis in a patient with caecal carcinoma. 19921643462
[atraumatic clostridium septicum infection in granulocytopenia].a fatal clostridium septicum infection occurred in three patients. case 1. a 55-year-old man died of septicaemia resulting from granulocytopenia of uncertain aetiology; it was associated with perforation of ileal mucosal ulcers. autopsy revealed neutropenic enterocolitis and diffuse gas formation, especially in the brain, caused by clostridium septicum. case 2. a 18-year-old boy developed a caecal invagination during imipenem-induced granulocytopenia. a fulminant postoperative clostridium septic ...19911743095
nontraumatic gas gangrene: case report and review of emergency therapeutics.gas gangrene is a well-recognized serious life and limb threatening emergency. in certain patients the source of this infection may be nontraumatic. we present an illustrative case of nontraumatic gas gangrene caused by clostridium septicum and review the literature regarding its emergency management. early recognition of nontraumatic gas gangrene is crucial to reduction of mortality and morbidity. emergent therapy requires resuscitation, surgical consultation, pharmacological therapy, and consi ...19911787289
an alternative to the toxin neutralization assay in mice for the potency testing of the clostridium tetani, clostridium septicum, clostridium novyi type b and clostridium perfringens type d epsilon components of multivalent sheep vaccines.potency testing of veterinary vaccines containing clostridial antigens currently requires the vaccination of laboratory rabbits followed by the determination of specific antitoxin concentration in the rabbit sera by toxin neutralization test in mice. elisas are described as an alternative method to toxin neutralization for the determination of clostridium tetani, clostridium septicum, clostridium novyi type b and clostridium perfringens type d epsilon antitoxins. the assays were found to be rapi ...19911797039
[clostridium septicum pyomyositis revealing colonic cancer]. 19911816023
mycotic aortic aneurysm infected by clostridium septicum--a case history.the authors describe a sixty-seven-year-old hypertensive, diabetic man with a mycotic abdominal aortic aneurysm infected with clostridium septicum. the patient had colonic polyps but no malignant disease. they could find only one other report of a mycotic aneurysm infected with c. septicum. in that case, as in most other cases of c. septicum bacteremia, the patient had gastrointestinal cancer. their case suggests that treatment for a clostridial infection should be considered in patients with kn ...19911863018
clostridium septicum bacteremia and diffuse spreading cellulitis of the head and neck in a leukemic patient. 19911866566
[a case of gas gangrene following operation of cervical esophageal carcinoma].a 74-year-old woman underwent surgery for cervical esophageal carcinoma. after operation, she had abdominal distension, high fever, and suddenly fell into shock and died. autopsy revealed necrosis and multiple gas blebs in the entire digestive tract and liver. direct smear specimens gram-stained disclosed clostridium septicum and the cause of death was found to be gas gangrene. this is the first of clostridium infection localized in the digestive tract and liver after operation. abdominal radiog ...19911886601
clostridium septicum myonecrosis and sepsis in the absence of trauma. 19911891736
clostridium septicum infection. beware of associated cancer.for reasons that are not fully understood, there is an association between clostridium septicum infection and carcinoma. in this article, dr kirchner describes the examination and treatment of a patient with c septicum infection in whom metastatic cancer was found on laparotomy.19911924004
recognition, management, and prevention of clostridium septicum abscess in immunosuppressed patients.spontaneous gas gangrene due to clostridium septicum is a rapidly progressing disease that usually ends in fatal toxemia. we report three cases of asymptomatic c septicum abscesses to document the clinical course of this entity and to establish guidelines for its prevention and treatment. in contrast to previously reported data, c septicum infections can produce abscesses in solid organs, the retroperitoneum, and the extremities. these lesions often occur in patients with cancer, producing liver ...19912021349
the sialidase gene from clostridium septicum: cloning, sequencing, expression in escherichia coli and identification of conserved sequences in sialidases and other proteins.an oligonucleotide mixture corresponding to the codons for conserved and repeated amino acid sequences of bacterial sialidases (roggentin et al. 1989) was used to clone a 4.3 kb psti restriction fragment of clostridium septicum dna in escherichia coli. the complete nucleotide sequence of the sialidase gene was determined from this fragment. the derived amino acid sequence corresponds to a protein of 110,000 da. the ribosomal binding site and promoter-like consensus sequences were identified upst ...19912034213
[clostridium septicum infection in tumor patients]. 19912044424
clostridium septicum gas gangrene and an intestinal malignant lesion. a case report. 19912045404
actions of three clostridial iga proteases on distinct forms of immunoglobulin a molecules.three bacterial species of clostridium (septicum, tertium and sporogenes) were identified to produce extracellular proteases cleaving iga to fab and fc fragments, as demonstrated by sds-page and immunoelectrophoretic procedures. these enzymes acted on monometric iga1 paraproteins and normal serum iga1 but had no activity on iga2 paraproteins and intact secretory iga1 from human colostrum. their action on polyclonal serum iga1 suggested the absence of neutralizing anti-clostridial iga protease ac ...19912071167
[clostridium septicum: a warning signal]. 19902098142
clostridium septicum gas gangrene following intramuscular infection from an influenza vaccine booster.we have reported a case of c septicum gas gangrene occurring in the forearm of a patient who had an influvac influenza booster 48 hours before admission. despite prompt antibiotic treatment and surgical debridement, the patient became hypotensive and could not be resuscitated.19902102204
a randomized prospective study of ceftazidime and ciprofloxacin with or without teicoplanin as an empiric antibiotic regimen for febrile neutropenic patients.febrile neutropenic patients were randomized to receive ceftazidime and ciprofloxacin with the addition of teicoplanin in cases with clinical suspicion of a hickman line-associated infection. at 48 h both clinical and bacteriological analyses were made. patients were categorized as: success, in cases of improvement or stability in the clinical condition; failure, if there was a deterioration of the clinical condition; and non-evaluable, in cases of protocol violation or death due to other causes ...19902149051
clostridium septicum as a cause of pericarditis and mycotic aneurysm.clostridium septicum is a bacterial species associated with gas gangrene in both humans and animals. although not usually a pathogen in humans, it has been implicated in some cases of abscesses and bacteremia. we now report the first case of pericarditis with mycotic aneurysm due to c. septicum.19902229369
in vitro tests for the measurement of veterinary clostridial toxins, toxoids and antisera. i. titration of clostridium septicum toxins and antitoxins in cell culture.the assay of clostridium septicum antitoxin currently requires the inoculation of test mixtures intravenously into mice or intradermally into guinea-pig skin. an alternative indicator system based on the use of cell cultures is described. evidence is presented to show that the toxins detected by the in vivo and in vitro indicators are indistinguishable in terms of molecular weight, charge and hydrophobicity and that there is a close agreement between the two methods of titration. cell culture in ...19902257131
spontaneous, nontraumatic gangrene due to clostridium septicum.clostridium septicum is a major cause of spontaneous, nontraumatic gas gangrene. unlike clostridium perfringens, c. septicum is relatively aerotolerant and thus appears to be more capable of initiating infection in the absence of obvious damage to tissues. six cases illustrate the clinical setting and fulminant nature of spontaneous gangrene caused by c. septicum. a lesion in the colon such as carcinoma is often present and is presumed to serve as a portal of entry to the bloodstream. diabetes a ...19902330482
activation of phospholipase a2 in rabbit erythrocyte membranes by a novel hemolytic toxin (h-toxin) of clostridium septicum.a primary effect of a novel h-toxin of clostridium septicum on the hemolysis of rabbit erythrocytes was shown to be the activation of phospholipase a2 (pla2) associated with rabbit erythrocyte membranes by 20-fold that of controls. furthermore, the activation of pla2 induced by the h-toxin was enhanced in the presence of nad. the h-toxin itself had no pla2 activity. on the contrary, the h-toxin bound to palmitic acid at a molar proportion of 1:1 and lost its hemolytic activity. the pla2 was not ...19902341026
aortitis due to metastatic gas gangrene.clostridium septicum bacteremia and its association with hematologic malignancy and colorectal cancer have been well recognized. panwalker, in a recent review, discussed clostridial sepsis and other unusual infections associated with colorectal tumors, including streptococcal bovis and bacteroides. he reports the coexistence of colorectal cancer and metastatic clostridium septicum infections at multiple sites. we describe a case in which a patient with an occult cecal carcinoma develops clostrid ...19892618068
clostridium septicum infection and associated malignancy. report of 2 cases and review of the literature.we report 2 patients with myonecrosis due to clostridium septicum and associated colon carcinoma and have reviewed the english language literature for all reported cases of atraumatic c. septicum infection. a total of 162 cases of c. septicum infection have been reported. eighty-one percent of these patients had an associated malignancy. thirty-four percent of all patients had associated colon carcinoma, while 40% had a hematologic malignancy. thirty-seven percent of reported patients had an occ ...19892642585
[clostridium septicum and colonic cancer].during the period 1980-1987, clostridium septicum was identified at statens seruminstitut, from anaerobic blood cultures in six patients. five of the patients had cancer of the colon or rectum (c. coli) and one had cancer of the ovary. correspondingly great incidence of solid tumours, particularly c. coli with c. septicum infection without preceding trauma or compromizing of immunity has been reported in the literature. meticulous bacteriological identification should be undertaken on anaerobic ...19892773100
clostridial sepsis and malignant disease.to address the significance of clostridial bacteremia in surgical patients, the bacteriologic records of the new york hospital from an eight year period were reviewed. of 1,708 patients who underwent surgical treatment with positive blood cultures, 23 (1.3 per cent) with clostridial bacteremia were identified. twenty-one of the 23 patients manifested clinical signs of sepsis at the time of clostridial bacteremia consisting of fever, leukocytosis or hypotension. fourteen patients had intra-abdomi ...19892814753
clostridium septicum and neutropenic enterocolitis. 19872887894
clostridium septicum and neutropenic enterocolitis. 19872890893
early diagnosis of clostridial gas gangrene using sialidase antibodies.in order to improve the diagnosis of gas gangrene, especially at an early stage of infection, new ways for the detection of the responsible clostridia were investigated. sialidase, known to be excreted in large amounts by the most frequently occurring myonecrotizing clostridial species, clostridium perfringens, clostridium septicum, and clostridium sordellii, was isolated. with polyclonal antibodies raised against these enzymes, two immunological assays were established, which are directed again ...19882898309
clostridial myositis in a dog.myositis caused by clostridium septicum was diagnosed in a 3-year-old doberman pinscher. the illness was characterized by signs of pain, swelling, and lameness of left forelimb. despite treatment, the dog died. necropsy revealed crepitant swelling over the entire left forelimb, thoracic and abdominal wall, and lumbosacral area. subcutaneous edema and black, emphysematous muscles also were found. histologically, hemorrhages, congested vessels, and degeneration and necrosis of myofibers with scatt ...19892914794
clostridium septicum myonecrosis in association with colonic malignancy. 19883069311
acute ileotyphlitis as presenting manifestation of acute myelogenous leukemia.a case of acute myelogenous leukemia is reported in a child who presented with acute ileotyphlitis and died of an over-whelming clostridium septicum sepsis before the chemotherapy was administered. the pathogenesis of acute ileotyphlitis, especially the role of granulocytopenia is discussed.19883162345
clostridium septicum infection in neutropenic enterocolitis.a 36-year-old woman developed neutropenia following chemotherapy for inoperable carcinoma of the cervix. she suffered acute abdominal pain, nausea, vomiting, and peritonitis of rapid onset. the right hemicolon and 15 cm of terminal ileum were resected at laparotomy and this showed marked edema of the cecum and ileo-cecal valve associated with superficial ulceration of the valve. there was necrosis of submucosal tissues and the muscle wall which contained a large number of gram-positive bacilli. ...19883211599
[a case of nontraumatic clostridium septicum infection with intrahepatic pneumatic tumor and adenocarcinoma of the transverse colon]. 19883250993
occult gastrointestinal carcinoma causing metastatic clostridial soft-tissue infection. report of two cases.the association between nontraumatic, metastatic, clostridial soft-tissue infection and malignancy is well recognized, particularly when clostridium septicum is involved. this report presents two patients with nontraumatic, metastatic, soft-tissue infection due to c. septicum and reviews the english medical literature. eighty-four percent of the reported patients were found to have colon carcinoma, which was postulated to be the portal of entry. prognosis is poor, but early recognition and antim ...19883282840
diffuse spreading clostridium septicum infection, malignant disease and immune suppression.nineteen patients have been treated with gas gangrene infection proved on cultures to be caused by clostridium septicum. infection occurred after trauma in three patients and occurred spontaneously in 16, including six patients with peritonitis. none of the instances occurred as a postoperative infection. ten of the patients had an associated malignant disease including carcinoma of the colon and rectum in six, hematologic malignant conditions in three and carcinoma of the gallbladder in one. of ...19883344448
clostridium septicum sepsis and cerebritis: a rare complication of the hemolytic-uremic syndrome. 19883380585
sudden visual loss associated with clostridial bacteraemia.a patient with endogenously acquired clostridium septicum panophthalmitis is presented. the patient exhibited a striking sequence of signs and symptoms associated with this devastating ocular infection. intensive antibiotic therapy was ineffective and enucleation of the globe was required. the microscopic pathology of the enucleated globe showed extensive infarction and necrosis of ocular structures in association with the panophthalmitis. in addition thrombosis of the central retinal artery and ...19883395597
quantitative method for determination of hemolytic activity of clostridium septicum toxin.a quantitative method for titration of hemolytic activity of clostridium septicum toxin was established. no linear dose-response line was obtained between the toxin dose and hemolysis ratio. logit or probit transformation of the hemolysis ratio changed this log-dose response curve into a linear line. we recommend a highly reproducible and accurate method based on parallel line assay using a well-standardized reference toxin for determination of hemolytic activity. the method consists of simultan ...19873430819
successful management of malignant edema caused by clostridium septicum in a horse.the clinical course and successful therapeutic management of a horse with malignant edema caused by clostridium septicum is described. this is believed to be the first report of a horse surviving malignant edema caused by c. septicum. a discussion of this disease syndrome, including etiology, pathogenesis, clinical signs, therapy, and diagnostic methods is presented.19873446445
nontraumatic clostridial myonecrosis, a case report.physicians are aware of the association between massively contaminated wounds and clostridial myonecrosis, or gas gangrene. a far less common but equally devastating presentation is that of nontraumatic or spontaneous gas gangrene. the most frequently encountered organism in this rare form of gangrene is clostridium septicum, and there is a high correlation with hematologic or gastrointestinal malignancy. the mainstays of treatment are intravenous antibiotics, surgical debridement, and hyperbari ...19863453908
arthritis caused by clostridium septicum. a case report and review of the literature. 19863512573
carcinoma of the large intestine and nontraumatic, metastatic, clostridial myonecrosis.traumatic, clostridial myonecrosis is a rare and serious complication of wounds. nontraumatic, metastatic, clostridial myonecrosis may be caused by carcinoma of the large intestine. nontraumatic myonecrosis becomes evident with localized pain, generalized toxicity, local signs of inflammation, and crepitation. serum creatine kinase determinations may be of help in diagnosing patients suspected of having acute myonecrosis. immediate heroic surgical intervention, usually with demonstration of clos ...19863539558
preparation of clostridium septicum antigen for hyperimmunization of horses using a dialyzed culture.the preparation of toxic cultures of clostridium septicum is described, using an apparatus with a straight dialysis tubing, where the medium is filled both into the nutrition and cultivation space of the apparatus. using the cultivation to nutrition volume rate 1:2, mean titre of lethal antigen in filtrates 3.86 limes mortis per ml and 300 dosis lethalis minima per lm was obtained in comparison with the values of 2.22 and 150 respectively in flask filtrates. native filtrates of dialyzed cultures ...19863539722
[gas gangrene: an extreme surgico-medical rather than medico-surgical emergency].a diabetic woman developed spontaneous gas gangrene of upper limb extending into trunk and due to clostridium septicum. recovery was obtained after major surgery involving disarticulation of upper limb and excision of soft tissues of left hemithorax, and a difficult intensive care programme (hyperbaric oxygen therapy, assisted ventilation). the presence of this gas gangrene revealed a bipolar colon cancer treated in parallel. the conventional therapeutic hierarchy is discussed: surgery should be ...19873584286
endogenous clostridium panophthalmitis.acute visual loss, pain, and redness in the left eye developed in a 61-year-old diabetic man. results of ophthalmologic examination showed 4+ conjunctival hyperemia and chemosis, no light perception, and restricted ocular motility. through a hazy cornea, a gas bubble was visualized filling about 50% of the anterior chamber. a vitreous tap disclosed myriad gram-positive rods with terminal and subterminal spores. cultures of the vitreous grew clostridium septicum, a gas-forming organism. explorato ...19873587922
splenic abscess due to clostridium septicum in a patient with multiple myeloma.solitary abscesses of the spleen may occur as a consequence of septicemia from various septic foci, particularly intra-abdominal sites. a variety of causative organisms, including the clostridia, have been isolated. we have described a patient with multiple myeloma who had a solitary splenic abscess due to clostridium septicum and who failed to survive despite seemingly appropriate treatment. clinicians should be alert to this complication, which demands immediate splenectomy and appropriate ant ...19873660050
clostridium septicum: spontaneous myonecrosis. 19873693880
clostridium septicum arthritis associated with colonic carcinoma. 19863735298
a case of nontraumatic clostridial gas gangrene occurring in a patient with colon adenocarcinoma, liver cirrhosis, and diabetes mellitus.an autopsy case of clostridial gas gangrene occurring in a 54-year-old man with colon adenocarcinoma, liver cirrhosis, and diabetes mellitus is reported. the patient died 4 days after the onset of symptoms with episodes of vomiting and abdominal pain. gangrene of both hips and perineum, hemolysis, renal failure, and disseminated intravascular coagulation were the dominant clinical features. clostridium septicum was isolated from the subcutaneous tissue fluid. adenocarcinoma of the ascending colo ...19863739709
dnase production by clostridium septicum.sixty-two clostridium septicum isolates were assayed for extracellular dnase activity. all of the c. septicum isolates tested produced greater dnase activity than did the other dnase-producing clostridial isolates tested. the molecular weight of the dnase of c. septicum was determined to be approximately 45,000. dnase is a major extracellular protein produced by this organism.19873818933
imipenem/cilastatin therapy of bacteremia.imipenem/cilastatin was used to treat 135 patients with bacteremia and signs of infection. ninety percent responded favorably. the bacteriologic eradication rate was 98 percent among the 153 isolates. only one patient had breakthrough bacteremia and this was a susceptible clostridium septicum. in two isolates of pseudomonas aeruginosa, emergence of resistance to imipenem during therapy was noted and appeared to be responsible for clinical failure. superinfection occurred in 13 patients and was r ...19853859221
[significance of clostridium septicum as a cause of gas edema].gas gangrene caused by clostridium septicum is relatively rare. in this paper 15 cases are described observed within the last 5 years. in 3 cases the gas gangrene was acquired exogenously. the other cases were endogenous infections. 9 of these cases were associated with colon carcinoma. c. septicum gas gangrene has a high lethality rate: 11 of the 15 patients died from the infection.19853884489
metastatic nontraumatic clostridium septicum osteomyelitis.nontraumatic clostridial infections are rare, but need to be diagnosed and treated early or high morbidity and mortality rates result. we believe that this is the first reported case of metastatic nontraumatic clostridium septicum osteomyelitis. early treatment with surgical debridement and parenteral antibiotics without hyperbaric oxygen was used. an associated occult rectal malignancy was discovered and treated.19853980945
[diffuse cellulitis and clostridium septicum septicemia in a non-cancer patient]. 19853982125
comparative in vitro activity of cefbuperazone against anaerobic bacteria isolated from community hospitals.the activity of cefbuperazone against 266 strains of anaerobic bacteria was determined by the agar dilution method and compared with cefoxitin, moxalactam, piperacillin, and clindamycin. all strains were recent clinical isolates from community hospitals. all agents tested showed good activity against bacteroides fragilis, fusobacterium spp., propionibacterium spp., clostridium septicum, clostridium perfringens, and the anaerobic, gram-positive cocci and gram-negative cocci. cefbuperazone, cefoxi ...19853985600
sialidase activity in the sera of patients and rabbits with clostridial myonecrosis.the origin and nature of gas gangrene can be diagnosed exactly only by time-consuming bacteriological tests. in order to improve the diagnostic procedures, rabbits were infected with strains of clostridium perfringens, clostridium septicum or clostridium sordellii. sialidase activity was found to increase rapidly in serum; elevated creatine kinase activities were observed, too. high sialidase concentrations were found in sera (up to 1.6 mu/ml) and in tissues of wounded regions (up to 110 mu/g) o ...19853987045
[ultrastructural characteristics of the natural heteromorphic growth of clostridium septicum].periodic cultures of c. septicum strain no. 59, growing in pope's broth, have been studied by means of transmission electron microscopy on ultrathin sections. during the lagphase of growth the inoculated bacilliary cells are sequentially converted into giant filamentous multinucleate forms. these changes, reflecting the reaction of phenotypical adaptation to new environmental conditions, are followed by the restoration of the initial phenotype via the fragmentation of the giant cells. at the sam ...19853993279
clostridium septicum septicemia with identical metastatic myonecroses in a granulocytopenic patient. infectious disease emergency.clostridium septicum is a gram-positive, sporulating spindle-shaped rod. gas gangrene secondary to trauma is not uncommon. however, nontraumatic clostridial infection causing myonecrosis is quite unusual. this is a unique case report of clostridium septicum bacteremia with two simultaneously evolving metastatic foci of myonecrosis of the left arm and right thigh that developed in a patient with lymphoma when he became granulocytopenic during his hospital course.19854025378
clostridium septicum panophthalmitis with systemic complications.a fulminant case of endophthalmitis due to clostridium septicum is described. the patient presented with spontaneous gas gangrene panophthalmitis, with early visual loss and an air bubble in the anterior chamber. death ensued, and necropsy revealed changes consistent with severe arterosclerotic cardiovascular disease, a relationship not uncommon in patients with clostridium sepsis. this association as well as the histopathology of the globe are discussed.19854052363
[effect of enterocin on clostridium perfringens and clostridium septicum (author's transl)]. 19744152346
glycolytic and related enzymes in clostridial classification.the activities of 15 glycolytic and related enzymes were determined in clostridia. all contained 1-phosphofructokinase; three of them lacked 6-phosphofructokinase and mannitol 1-phosphate dehydrogenase. glucose 6-phosphate dehydrogenase was found in six clostridia, thus demonstrating the presence of hexose monophosphate shunt. only parts of the citric acid cycle were found to be present in most clostridia with an indication of the full cycle in clostridium septicum. the intermediary enzyme activ ...19694244302
[enterogenous non-traumatic gas phlegmon infection by clostridium septicum]. 19714327293
[composition of the gases given off by clostridium septicum, clostridium chauvoei and welchia perfringens cultured in a sodium thioglycolate medium under vacuum after alkalinization of the medium at the end of cultivation]. 19724338943
prevention of swarming of clostridium septicum. 19724566879
letter: sudden deaths from clostridium septicum infection of the gobabis district. 19724670770
[non-traumatic infection with clostridium septicum]. 19734741475
adenocarcinoma of the colon presenting as clostridium septicum cellulitis of the left thigh. 19744834747
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